SCML1 Gene
protein-coding GIFtS: 43
GCID: GC0XP017755
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sex comb on midleg-like 1 (Drosophila)(Previous name: sex comb on midleg (Drosophila)-like 1 )
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Aliases
for SCML1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sex Comb On Midleg-Like 1 (Drosophila)1 2 | | Sex Comb On Midleg (Drosophila)-Like 11 | | Sex Comb On Midleg-Like Protein 12 |
Export aliases for SCML1 gene to outside databasesPrevious GC identifers: GC0XP017299 GC0XP016421 GC0XP016957 GC0XP017117 GC0XP017515 GC0XP017665 GC0XP015514 |
Summaries
for SCML1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SCML1_HUMAN, Q9UN30Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are requiredto maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved inspermatogenesis during sexual maturation (By similarity)
|
Genomic Views
for SCML1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCML1 gene promoter:
Pax-2 Pax-2a LUN-1 YY1 Evi-1 HEN1 POU2F1 POU2F1a aMEF-2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCML1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCML1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22 Ensembl cytogenetic band: Xp22.13 HGNC cytogenetic band: Xp22SCML1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP017755: view genomic region
(about GC identifiers)
Start:
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17,755,588 bp from pter |
End:
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17,773,105 bp from pter |
Size:
|
17,518 bases |
Orientation:
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plus strand |
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Proteins
for SCML1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCML1_HUMAN, Q9UN30 (See
protein sequence)Recommended Name: Sex comb on midleg-like protein 1 Size: 329 amino acids; 37447 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B0FZN6 B2RA08 Q5H968 Q5H969Alternative splicing: 3 isoforms: Q9UN30-3 Q9UN30-1 Q9UN30-2 Explore the universe of human proteins at neXtProt for SCML1: NX_Q9UN30
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UN30
SCML1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001032624.1 NP_001032625.1 NP_001032629.1 NP_006737.2
ENSEMBL proteins: ENSP00000369384 ENSP00000369380 ENSP00000369382 ENSP00000392587 ENSP00000381154
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SCML1 for ontologies About GeneDecksing
SCML1 Antibody Products:
Assay Products for SCML1: |
Protein
Domains /
Families
for SCML1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCML1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UN30ProtoNet protein and cluster: Q9UN30 1 Blocks protein family: IPB001660 Sterile alpha motif SAM
UniProtKB/Swiss-Prot: SCML1_HUMAN, Q9UN30Similarity: Belongs to the SCM familySimilarity: Contains 1 SAM (sterile alpha motif) domain |
Function
for SCML1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SCML1_HUMAN, Q9UN30Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are requiredto maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved inspermatogenesis during sexual maturation (By similarity) Genatlas biochemistry entry for SCML1:Drosophila sex comb on midleg-like 1 homolog,polycomb group (PcG),involved in transcriptional repression of HOX genes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCML1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCML1 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SCML1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCML1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SCML1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SCML1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCML1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for SCML1 (ENSP000003693804) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0009653 | anatomical structure morphogenesis |
TAS | 9570953 |
SCML1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SCML1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SCML1
Search CenterWatch for drugs/clinical trials and news about SCML1
|
Transcripts
for SCML1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCML1 gene (4 alternative transcripts): NM_001037535.1 NM_001037536.1 NM_001037540.1 NM_006746.4 Unigene Cluster for SCML1: Sex comb on midleg-like 1 (Drosophila) Hs.109655 [show with all ESTs]Unigene Representative Sequence: NM_0010375407 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380045(uc004cyd.3) ENST00000380041 ENST00000380043(uc004cyb.3 uc004cyc.3 uc004cye.3)
ENST00000427362 ENST00000419185 ENST00000487842 ENST00000398080
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCML1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCML1 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): SCML1 (NM_001037540) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCML1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML1 |
Additional cDNA sequence: AF160728.1 AK313993.1 BC009193.2 BC026159.2 BC105028.1 11 DOTS entries: DT.100748552 DT.95369106 DT.310945 DT.95251213 DT.86999637 DT.92437725 DT.95369117 DT.92437739 DT.121278083 DT.412147 DT.95317901 24/160 AceView cDNA sequences (see all 160): CD370105 CD742734 AK094942 AV719246 NM_006746 AV728506 AI269405 AL705642 W69459 AI537061 AL599473 AA907676 AI978764 BE794092 BC026159 BM141950 BF224399 AI275982 AV689073 BX954248 AW593093 AF160728 BF059263 AI431345
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SCML1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 |
|---|
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| SP1: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SCML1
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Expression
for SCML1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCML1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATAAGATT
About this image
See SCML1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCML1
SOURCE GeneReport for Unigene cluster: Hs.109655
UniProtKB/Swiss-Prot: SCML1_HUMAN, Q9UN30Tissue specificity: Ubiquitous. Expressed in fetal and adult tissues
SABiosciences Custom PCR Arrays for SCML1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCML1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCML1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCML1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCML1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCML1 |
Orthologs
for SCML1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SCML1 (if available)
TreeFam Gene Tree for SCML1 (if available) |
Paralogs
for SCML1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SCML1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCML1 (17755588 - 17773105 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCML1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCML1 |
|
Disorders
/ Diseases
for SCML1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SCML1 for disorders About MalaCards
SCML1 for disorders About GeneDecksing
OMIM gene information: 300227
OMIM disorders: --
Export disorders for SCML1 gene to outside databases
|
Publications
for SCML1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCML1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SCML1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes. (PubMed id 9570953)1, 2, 3 van de Vosse E....Trump D. (1998)
- Adaptive evolution of SCML1 in primates, a gene involved in male reproduction. (PubMed id 18601738)1, 2 Wu H.-H. and Su B. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SCML1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCML1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCML1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCML1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SCML1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SCML1 gene:
Search GeneIP for patents involving SCML1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCML1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SCML1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCML1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCML1 | | | OriGene Protein Over-expression Lysate for SCML1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SCML1 | | OriGene 3'-UTR Clone for SCML1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCML1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCML1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SCML1 | | OriGene Custom Protein Services for SCML1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCML1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCML1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCML1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCML1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCML1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCML1 |
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| | | | Search Tocris compounds for SCML1 |
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 | | | SCML1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCML1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SCML1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCML1 |
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