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Aliases for SCML1 Gene

Aliases for SCML1 Gene

  • Sex Comb On Midleg-Like 1 (Drosophila) 2 3
  • Sex Comb On Midleg (Drosophila)-Like 1 2

External Ids for SCML1 Gene

Previous GeneCards Identifiers for SCML1 Gene

  • GC0XP017299
  • GC0XP016421
  • GC0XP016957
  • GC0XP017117
  • GC0XP017515
  • GC0XP017665
  • GC0XP015514

Summaries for SCML1 Gene

GeneCards Summary for SCML1 Gene

SCML1 (Sex Comb On Midleg-Like 1 (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SCMH1.

UniProtKB/Swiss-Prot for SCML1 Gene

  • Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCML1 Gene

Genomics for SCML1 Gene

Regulatory Elements for SCML1 Gene

Genomic Location for SCML1 Gene

Start:
17,737,449 bp from pter
End:
17,754,988 bp from pter
Size:
17,540 bases
Orientation:
Plus strand

Genomic View for SCML1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCML1 Gene

Proteins for SCML1 Gene

  • Protein details for SCML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN30-SCML1_HUMAN
    Recommended name:
    Sex comb on midleg-like protein 1
    Protein Accession:
    Q9UN30
    Secondary Accessions:
    • B0FZN6
    • B2RA08
    • Q5H968
    • Q5H969

    Protein attributes for SCML1 Gene

    Size:
    329 amino acids
    Molecular mass:
    37447 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCML1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCML1 Gene

Proteomics data for SCML1 Gene at MOPED

Post-translational modifications for SCML1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCML1 Gene

Domains for SCML1 Gene

Gene Families for SCML1 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for SCML1 Gene

Suggested Antigen Peptide Sequences for SCML1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UN30

UniProtKB/Swiss-Prot:

SCML1_HUMAN :
  • Q9UN30
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the SCM family.
genes like me logo Genes that share domains with SCML1: view

Function for SCML1 Gene

Molecular function for SCML1 Gene

GENATLAS Biochemistry: Drosophila sex comb on midleg-like 1 homolog,polycomb group (PcG),involved in transcriptional repression of HOX genes
UniProtKB/Swiss-Prot Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity).

Gene Ontology (GO) - Molecular Function for SCML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9570953
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9570953
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SCML1: view

miRNA for SCML1 Gene

miRTarBase miRNAs that target SCML1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCML1 Gene

Localization for SCML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCML1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCML1 Gene COMPARTMENTS Subcellular localization image for SCML1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SCML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SCML1: view

Pathways for SCML1 Gene

SuperPathways for SCML1 Gene

No Data Available

Interacting Proteins for SCML1 Gene

Gene Ontology (GO) - Biological Process for SCML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009653 anatomical structure morphogenesis TAS 9570953
genes like me logo Genes that share ontologies with SCML1: view

No data available for Pathways by source for SCML1 Gene

Transcripts for SCML1 Gene

Unigene Clusters for SCML1 Gene

Sex comb on midleg-like 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCML1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - -
SP8: -
SP9:
SP10:

Relevant External Links for SCML1 Gene

GeneLoc Exon Structure for
SCML1
ECgene alternative splicing isoforms for
SCML1

Expression for SCML1 Gene

mRNA expression in normal human tissues for SCML1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCML1 Gene

SOURCE GeneReport for Unigene cluster for SCML1 Gene Hs.109655

mRNA Expression by UniProt/SwissProt for SCML1 Gene

Q9UN30-SCML1_HUMAN
Tissue specificity: Ubiquitous. Expressed in fetal and adult tissues.
genes like me logo Genes that share expressions with SCML1: view

No data available for mRNA differential expression in normal tissues for SCML1 Gene

Orthologs for SCML1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCML1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCML1 35
  • 96.96 (n)
  • 92.1 (a)
SCML1 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCML1 35
  • 64.96 (n)
  • 46.33 (a)
SCML1 36
  • 43 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCML1 35
  • 68.21 (n)
  • 56.04 (a)
SCML1 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 15 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii l3mbtl1b 36
  • 6 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta l(3)mbt 36
  • 2 (a)
OneToMany
Species with no ortholog for SCML1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCML1 Gene

ENSEMBL:
Gene Tree for SCML1 (if available)
TreeFam:
Gene Tree for SCML1 (if available)

Paralogs for SCML1 Gene

genes like me logo Genes that share paralogs with SCML1: view

Variants for SCML1 Gene

Sequence variations from dbSNP and Humsavar for SCML1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1054808 -- 17,753,940(+) GTTTT(A/T)TTTAT utr-variant-3-prime
rs3788770 -- 17,750,922(+) AGGGA(C/G)TCTAA intron-variant
rs4825321 -- 17,747,053(+) TCTGG(A/G)AGCAG intron-variant
rs6629244 -- 17,755,322(+) CCCAT(C/G)TGAGC downstream-variant-500B
rs6633024 -- 17,752,012(+) TTGAA(G/T)GACCT intron-variant

Relevant External Links for SCML1 Gene

HapMap Linkage Disequilibrium report
SCML1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCML1 Gene

Disorders for SCML1 Gene

No disorders were found for SCML1 Gene.

No data available for UniProtKB/Swiss-Prot for SCML1 Gene

Publications for SCML1 Gene

  1. Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes. (PMID: 9570953) van de Vosse E. … Trump D. (Genomics 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Adaptive evolution of SCML1 in primates, a gene involved in male reproduction. (PMID: 18601738) Wu H.-H. … Su B. (BMC Evol. Biol. 2008) 3 4

Products for SCML1 Gene

Sources for SCML1 Gene

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