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Aliases for SCML1 Gene

Aliases for SCML1 Gene

  • Sex Comb On Midleg Like 1 (Drosophila) 2 3
  • Sex Comb On Midleg (Drosophila)-Like 1 2
  • Sex Comb On Midleg-Like 1 (Drosophila) 5

External Ids for SCML1 Gene

Previous GeneCards Identifiers for SCML1 Gene

  • GC0XP017299
  • GC0XP016421
  • GC0XP016957
  • GC0XP017117
  • GC0XP017515
  • GC0XP017665
  • GC0XP015514

Summaries for SCML1 Gene

GeneCards Summary for SCML1 Gene

SCML1 (Sex Comb On Midleg Like 1 (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for SCML1 Gene

  • Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCML1 Gene

Genomics for SCML1 Gene

Regulatory Elements for SCML1 Gene

Enhancers for SCML1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG017735 2 ENCODE 8.3 -0.1 -113 4.4 PKNOX1 ATF1 SIN3A BRCA1 YY1 GLIS2 ELK1 ZNF143 SP3 SP5 SCML1 ENSG00000226153
GH0XG017593 1 Ensembl ENCODE 4.2 -141.9 -141917 3.4 MTA2 JUN HLF FEZF1 FOXA1 OSR2 NFIL3 PRDM6 ZNF157 CEBPA SCML1 SCML2 NHS-AS1 GC0XM017645
GH0XG017706 0.7 ENCODE 0.3 -30.6 -30564 0.1 GTF2F1 GATAD2A HMG20B FOXA2 SAP130 TEAD1 JUN HLF CEBPB CEBPG ENSG00000226153 SCML1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCML1 on UCSC Golden Path with GeneCards custom track

Promoters for SCML1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000244963 451 3001 PKNOX1 ATF1 SIN3A BRCA1 YY1 GLIS2 ELK1 ZNF143 SP3 SP5

Genomic Location for SCML1 Gene

Chromosome:
X
Start:
17,737,449 bp from pter
End:
17,754,988 bp from pter
Size:
17,540 bases
Orientation:
Plus strand

Genomic View for SCML1 Gene

Genes around SCML1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCML1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCML1 Gene

Proteins for SCML1 Gene

  • Protein details for SCML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN30-SCML1_HUMAN
    Recommended name:
    Sex comb on midleg-like protein 1
    Protein Accession:
    Q9UN30
    Secondary Accessions:
    • B0FZN6
    • B2RA08
    • Q5H968
    • Q5H969

    Protein attributes for SCML1 Gene

    Size:
    329 amino acids
    Molecular mass:
    37447 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCML1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCML1 Gene

Post-translational modifications for SCML1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SCML1

No data available for DME Specific Peptides for SCML1 Gene

Domains & Families for SCML1 Gene

Gene Families for SCML1 Gene

Protein Domains for SCML1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCML1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UN30

UniProtKB/Swiss-Prot:

SCML1_HUMAN :
  • Belongs to the SCM family.
Family:
  • Belongs to the SCM family.
genes like me logo Genes that share domains with SCML1: view

Function for SCML1 Gene

Molecular function for SCML1 Gene

GENATLAS Biochemistry:
Drosophila sex comb on midleg-like 1 homolog,polycomb group (PcG),involved in transcriptional repression of HOX genes
UniProtKB/Swiss-Prot Function:
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity).

Gene Ontology (GO) - Molecular Function for SCML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9570953
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9570953
genes like me logo Genes that share ontologies with SCML1: view
genes like me logo Genes that share phenotypes with SCML1: view

miRNA for SCML1 Gene

miRTarBase miRNAs that target SCML1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCML1 Gene

Localization for SCML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCML1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCML1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SCML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SCML1: view

Pathways & Interactions for SCML1 Gene

SuperPathways for SCML1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009653 anatomical structure morphogenesis TAS 9570953
genes like me logo Genes that share ontologies with SCML1: view

No data available for Pathways by source and SIGNOR curated interactions for SCML1 Gene

Transcripts for SCML1 Gene

Unigene Clusters for SCML1 Gene

Sex comb on midleg-like 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCML1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - -
SP8: -
SP9:
SP10:

Relevant External Links for SCML1 Gene

GeneLoc Exon Structure for
SCML1
ECgene alternative splicing isoforms for
SCML1

Expression for SCML1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCML1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCML1 Gene

This gene is overexpressed in Testis (40.1), Ovary (18.0), and Plasma (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCML1 Gene



Protein tissue co-expression partners for SCML1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCML1 Gene:

SCML1

SOURCE GeneReport for Unigene cluster for SCML1 Gene:

Hs.109655

mRNA Expression by UniProt/SwissProt for SCML1 Gene:

Q9UN30-SCML1_HUMAN
Tissue specificity: Ubiquitous. Expressed in fetal and adult tissues.

Evidence on tissue expression from TISSUES for SCML1 Gene

  • Liver(4.4)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SCML1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCML1 Gene

Orthologs for SCML1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCML1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCML1 34 35
  • 96.96 (n)
dog
(Canis familiaris)
Mammalia SCML1 34 35
  • 68.21 (n)
cow
(Bos Taurus)
Mammalia SCML1 34 35
  • 64.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 15 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii l3mbtl1b 35
  • 6 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta l(3)mbt 35
  • 2 (a)
OneToMany
Species where no ortholog for SCML1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCML1 Gene

ENSEMBL:
Gene Tree for SCML1 (if available)
TreeFam:
Gene Tree for SCML1 (if available)

Paralogs for SCML1 Gene

No data available for Paralogs for SCML1 Gene

Variants for SCML1 Gene

Sequence variations from dbSNP and Humsavar for SCML1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000006818 -- 17,740,475(+) GAGGT(A/G)TGTGC intron-variant, upstream-variant-2KB
rs1000071516 -- 17,738,518(+) GGATG(C/T)GGTTC intron-variant
rs1000122345 -- 17,751,614(+) GGGAC(A/G)CTCTT intron-variant
rs1000474142 -- 17,748,004(+) CCATC(A/T)GAATC intron-variant
rs1000547783 -- 17,740,829(+) TGGAC(G/T)GAGGG intron-variant, upstream-variant-2KB

Variation tolerance for SCML1 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCML1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCML1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCML1 Gene

Disorders for SCML1 Gene

Relevant External Links for SCML1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCML1

No disorders were found for SCML1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCML1 Gene

Publications for SCML1 Gene

  1. Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes. (PMID: 9570953) van de Vosse E. … Trump D. (Genomics 1998) 2 3 4 64
  2. Adaptive evolution of SCML1 in primates, a gene involved in male reproduction. (PMID: 18601738) Wu H.-H. … Su B. (BMC Evol. Biol. 2008) 3 4 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SCML1 Gene

Sources for SCML1 Gene

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