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Aliases for SCMH1 Gene

Aliases for SCMH1 Gene

  • Sex Comb On Midleg Homolog 1 (Drosophila) 2 3 5
  • Sex Comb On Midleg Homolog 1 4
  • Scml3 3

External Ids for SCMH1 Gene

Previous GeneCards Identifiers for SCMH1 Gene

  • GC01M041527
  • GC01M040496
  • GC01M040956
  • GC01M040906
  • GC01M041161
  • GC01M041265
  • GC01M039609

Summaries for SCMH1 Gene

GeneCards Summary for SCMH1 Gene

SCMH1 (Sex Comb On Midleg Homolog 1 (Drosophila)) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is L3MBTL1.

UniProtKB/Swiss-Prot for SCMH1 Gene

  • Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.

Gene Wiki entry for SCMH1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCMH1 Gene

Genomics for SCMH1 Gene

Regulatory Elements for SCMH1 Gene

Enhancers for SCMH1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCMH1 on UCSC Golden Path with GeneCards custom track

Promoters for SCMH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCMH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCMH1 Gene

Chromosome:
1
Start:
41,027,199 bp from pter
End:
41,242,159 bp from pter
Size:
214,961 bases
Orientation:
Minus strand

Genomic View for SCMH1 Gene

Genes around SCMH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCMH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCMH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCMH1 Gene

Proteins for SCMH1 Gene

  • Protein details for SCMH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GD3-SCMH1_HUMAN
    Recommended name:
    Polycomb protein SCMH1
    Protein Accession:
    Q96GD3
    Secondary Accessions:
    • B4DRQ8
    • Q5VT76
    • Q6IAJ4
    • Q8WU48
    • Q9UKM5
    • Q9UKM6

    Protein attributes for SCMH1 Gene

    Size:
    660 amino acids
    Molecular mass:
    73354 Da
    Quaternary structure:
    • Interacts with the SAM domain of PHC1 via its SAM domain in vitro (By similarity). Associates with a PRC1-like complex.

    Three dimensional structures from OCA and Proteopedia for SCMH1 Gene

    Alternative splice isoforms for SCMH1 Gene

neXtProt entry for SCMH1 Gene

Proteomics data for SCMH1 Gene at MOPED

Post-translational modifications for SCMH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCMH1 Gene

Domains & Families for SCMH1 Gene

Protein Domains for SCMH1 Gene

Suggested Antigen Peptide Sequences for SCMH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96GD3

UniProtKB/Swiss-Prot:

SCMH1_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the SCM family.
  • Contains 2 MBT repeats.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the SCM family.
Similarity:
  • Contains 2 MBT repeats.
genes like me logo Genes that share domains with SCMH1: view

Function for SCMH1 Gene

Molecular function for SCMH1 Gene

GENATLAS Biochemistry:
Drosophila sex comb on midley homolog,widely expressed,with isoforms
UniProtKB/Swiss-Prot Function:
Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.

Gene Ontology (GO) - Molecular Function for SCMH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with SCMH1: view
genes like me logo Genes that share phenotypes with SCMH1: view

Animal Models for SCMH1 Gene

MGI Knock Outs for SCMH1:

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCMH1 Gene

Localization for SCMH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCMH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCMH1 Gene COMPARTMENTS Subcellular localization image for SCMH1 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for SCMH1 Gene

Pathways & Interactions for SCMH1 Gene

genes like me logo Genes that share pathways with SCMH1: view

Gene Ontology (GO) - Biological Process for SCMH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IEA --
GO:0009653 anatomical structure morphogenesis TAS 10524249
GO:0009952 anterior/posterior pattern specification IEA --
GO:0016925 protein sumoylation TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with SCMH1: view

No data available for SIGNOR curated interactions for SCMH1 Gene

Drugs & Compounds for SCMH1 Gene

(1) Drugs for SCMH1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beta-Mercaptoethanol Experimental Pharma Target 0
genes like me logo Genes that share compounds with SCMH1: view

Transcripts for SCMH1 Gene

Unigene Clusters for SCMH1 Gene

Sex comb on midleg homolog 1 (Drosophila):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCMH1 Gene

No ASD Table

Relevant External Links for SCMH1 Gene

GeneLoc Exon Structure for
SCMH1
ECgene alternative splicing isoforms for
SCMH1

Expression for SCMH1 Gene

mRNA expression in normal human tissues for SCMH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCMH1 Gene



SOURCE GeneReport for Unigene cluster for SCMH1 Gene Hs.571874

mRNA Expression by UniProt/SwissProt for SCMH1 Gene

Q96GD3-SCMH1_HUMAN
Tissue specificity: Strongly expressed in heart, muscle and pancreas. Weakly expressed in brain, placenta, lung, liver and kidney.
genes like me logo Genes that share expression patterns with SCMH1: view

Protein tissue co-expression partners for SCMH1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for SCMH1 Gene

Orthologs for SCMH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCMH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCMH1 35
  • 92.94 (n)
  • 94.66 (a)
SCMH1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCMH1 35
  • 94.2 (n)
  • 95.77 (a)
SCMH1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scmh1 35
  • 91.3 (n)
  • 93.93 (a)
Scmh1 16
Scmh1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCMH1 35
  • 99.85 (n)
  • 100 (a)
SCMH1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scmh1 35
  • 91.35 (n)
  • 93.63 (a)
oppossum
(Monodelphis domestica)
Mammalia SCMH1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCMH1 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCMH1 35
  • 79.39 (n)
  • 86.02 (a)
SCMH1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCMH1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scmh1 35
  • 68.82 (n)
  • 77.11 (a)
Str.17540 35
zebrafish
(Danio rerio)
Actinopterygii scmh1 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Scm 37
  • 58 (a)
Scm 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6357 36
  • 30 (a)
OneToMany
Species with no ortholog for SCMH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCMH1 Gene

ENSEMBL:
Gene Tree for SCMH1 (if available)
TreeFam:
Gene Tree for SCMH1 (if available)

Paralogs for SCMH1 Gene

Paralogs for SCMH1 Gene

(5) SIMAP similar genes for SCMH1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SCMH1 Gene

genes like me logo Genes that share paralogs with SCMH1: view

Variants for SCMH1 Gene

Sequence variations from dbSNP and Humsavar for SCMH1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9938 -- 41,168,797(+) TCTCT(A/T)ATCTC intron-variant
rs18996 -- 41,158,848(-) GAGAA(A/G)CTCTA intron-variant
rs183334 -- 41,146,431(+) tggta(A/C/T)gcagt intron-variant
rs475390 -- 41,104,787(-) TTTTT(C/T)CTAAT intron-variant
rs213731 -- 41,112,526(+) CTCAT(A/T)GGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCMH1 Gene

Variant ID Type Subtype PubMed ID
esv269066 CNV Insertion 20981092
esv2669275 CNV Deletion 23128226
esv24588 CNV Loss 19812545
nsv519146 CNV Gain 19592680
esv2571087 CNV Deletion 19546169

Variation tolerance for SCMH1 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCMH1 Gene

HapMap Linkage Disequilibrium report
SCMH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCMH1 Gene

Disorders for SCMH1 Gene

Relevant External Links for SCMH1

Genetic Association Database (GAD)
SCMH1
Human Genome Epidemiology (HuGE) Navigator
SCMH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCMH1

No disorders were found for SCMH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCMH1 Gene

Publications for SCMH1 Gene

  1. The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34. (PMID: 10524249) Berger J. … Randazzo F. (Gene 1999) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 3

Products for SCMH1 Gene

Sources for SCMH1 Gene

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