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Aliases for SCMH1 Gene

Aliases for SCMH1 Gene

  • Sex Comb On Midleg Homolog 1 (Drosophila) 2 3
  • Sex Comb On Midleg Homolog 1 4
  • Polycomb Protein SCMH1 3
  • Scml3 3

External Ids for SCMH1 Gene

Previous GeneCards Identifiers for SCMH1 Gene

  • GC01M041527
  • GC01M040496
  • GC01M040956
  • GC01M040906
  • GC01M041161
  • GC01M041265
  • GC01M039609

Summaries for SCMH1 Gene

GeneCards Summary for SCMH1 Gene

SCMH1 (Sex Comb On Midleg Homolog 1 (Drosophila)) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cellular Senescence. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SCML2.

UniProtKB/Swiss-Prot for SCMH1 Gene

  • Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.

Gene Wiki entry for SCMH1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCMH1 Gene

Genomics for SCMH1 Gene

Regulatory Elements for SCMH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCMH1 Gene

Start:
41,027,199 bp from pter
End:
41,242,154 bp from pter
Size:
214,956 bases
Orientation:
Minus strand

Genomic View for SCMH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCMH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCMH1 Gene

Proteins for SCMH1 Gene

  • Protein details for SCMH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GD3-SCMH1_HUMAN
    Recommended name:
    Polycomb protein SCMH1
    Protein Accession:
    Q96GD3
    Secondary Accessions:
    • B4DRQ8
    • Q5VT76
    • Q6IAJ4
    • Q8WU48
    • Q9UKM5
    • Q9UKM6

    Protein attributes for SCMH1 Gene

    Size:
    660 amino acids
    Molecular mass:
    73354 Da
    Quaternary structure:
    • Interacts with the SAM domain of PHC1 via its SAM domain in vitro (By similarity). Associates with a PRC1-like complex.

    Three dimensional structures from OCA and Proteopedia for SCMH1 Gene

    Alternative splice isoforms for SCMH1 Gene

neXtProt entry for SCMH1 Gene

Proteomics data for SCMH1 Gene at MOPED

Post-translational modifications for SCMH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCMH1 Gene

Domains for SCMH1 Gene

Gene Families for SCMH1 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for SCMH1 Gene

Suggested Antigen Peptide Sequences for SCMH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96GD3

UniProtKB/Swiss-Prot:

SCMH1_HUMAN :
  • Q96GD3
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the SCM family.
Similarity:
  • Contains 2 MBT repeats.
genes like me logo Genes that share domains with SCMH1: view

Function for SCMH1 Gene

Molecular function for SCMH1 Gene

GENATLAS Biochemistry: Drosophila sex comb on midley homolog,widely expressed,with isoforms
UniProtKB/Swiss-Prot Function: Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.

Gene Ontology (GO) - Molecular Function for SCMH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10524249
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10524249
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with SCMH1: view
genes like me logo Genes that share phenotypes with SCMH1: view

Animal Models for SCMH1 Gene

MGI Knock Outs for SCMH1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCMH1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SCMH1 Gene

Localization for SCMH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCMH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCMH1 Gene COMPARTMENTS Subcellular localization image for SCMH1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SCMH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 10524249
GO:0005654 nucleoplasm TAS --
GO:0010369 chromocenter IEA --
genes like me logo Genes that share ontologies with SCMH1: view

Pathways for SCMH1 Gene

genes like me logo Genes that share pathways with SCMH1: view

Pathways by source for SCMH1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for SCMH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007283 spermatogenesis IEA --
GO:0009653 anatomical structure morphogenesis TAS 10524249
genes like me logo Genes that share ontologies with SCMH1: view

Compounds for SCMH1 Gene

(1) Drugbank Compounds for SCMH1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Beta-Mercaptoethanol
60-24-2 target
genes like me logo Genes that share compounds with SCMH1: view

Transcripts for SCMH1 Gene

Unigene Clusters for SCMH1 Gene

Sex comb on midleg homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCMH1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCMH1 Gene

No ASD Table

Relevant External Links for SCMH1 Gene

GeneLoc Exon Structure for
SCMH1
ECgene alternative splicing isoforms for
SCMH1

Expression for SCMH1 Gene

mRNA expression in normal human tissues for SCMH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCMH1 Gene

SOURCE GeneReport for Unigene cluster for SCMH1 Gene Hs.571874

mRNA Expression by UniProt/SwissProt for SCMH1 Gene

Q96GD3-SCMH1_HUMAN
Tissue specificity: Strongly expressed in heart, muscle and pancreas. Weakly expressed in brain, placenta, lung, liver and kidney.
genes like me logo Genes that share expressions with SCMH1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SCMH1 Gene

Orthologs for SCMH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCMH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCMH1 35
  • 99.85 (n)
  • 100 (a)
SCMH1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCMH1 35
  • 92.94 (n)
  • 94.66 (a)
SCMH1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCMH1 35
  • 94.2 (n)
  • 95.77 (a)
SCMH1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scmh1 35
  • 91.3 (n)
  • 93.93 (a)
Scmh1 16
Scmh1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCMH1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCMH1 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scmh1 35
  • 91.35 (n)
  • 93.63 (a)
chicken
(Gallus gallus)
Aves SCMH1 35
  • 79.39 (n)
  • 86.02 (a)
SCMH1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCMH1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scmh1 35
  • 68.82 (n)
  • 77.11 (a)
Str.17540 35
zebrafish
(Danio rerio)
Actinopterygii scmh1 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Scm 36
  • 27 (a)
OneToMany
Scm 37
  • 58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6357 36
  • 30 (a)
OneToMany
Species with no ortholog for SCMH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCMH1 Gene

ENSEMBL:
Gene Tree for SCMH1 (if available)
TreeFam:
Gene Tree for SCMH1 (if available)

Paralogs for SCMH1 Gene

Selected SIMAP similar genes for SCMH1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SCMH1 Gene

genes like me logo Genes that share paralogs with SCMH1: view

Variants for SCMH1 Gene

Sequence variations from dbSNP and Humsavar for SCMH1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9938 -- 41,168,797(+) TCTCT(A/T)ATCTC intron-variant
rs18996 -- 41,158,848(-) GAGAA(A/G)CTCTA intron-variant
rs183334 -- 41,146,431(+) tggta(A/C)gcagt intron-variant
rs213731 -- 41,112,526(+) CTCAT(A/T)GGTAG intron-variant
rs213732 -- 41,112,442(+) CTGGA(C/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCMH1 Gene

Variant ID Type Subtype PubMed ID
esv269066 CNV Insertion 20981092
esv2669275 CNV Deletion 23128226
esv24588 CNV Loss 19812545
nsv519146 CNV Gain 19592680
esv2571087 CNV Deletion 19546169

Relevant External Links for SCMH1 Gene

HapMap Linkage Disequilibrium report
SCMH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCMH1 Gene

Disorders for SCMH1 Gene

Relevant External Links for SCMH1

Genetic Association Database (GAD)
SCMH1
Human Genome Epidemiology (HuGE) Navigator
SCMH1
genes like me logo Genes that share disorders with SCMH1: view

No data available for UniProtKB/Swiss-Prot for SCMH1 Gene

Publications for SCMH1 Gene

  1. The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34. (PMID: 10524249) Berger J. … Randazzo F. (Gene 1999) 2 3 4
  2. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PMID: 12167701) Levine S.S. … Kingston R.E. (Mol. Cell. Biol. 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for SCMH1 Gene

Sources for SCMH1 Gene

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