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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCLY Gene

protein-coding   GIFtS: 59
GCID: GC02P238985

Selenocysteine Lyase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Selenocysteine Lyase1 2
SCL2 3 5
hSCL2 3
EC 4.4.1.163 8
Putative Selenocysteine Lyase1

External Ids:    HGNC: 181611   Entrez Gene: 515402   Ensembl: ENSG000001323307   OMIM: 6110565   UniProtKB: Q96I153   

Export aliases for SCLY gene to outside databases

Previous GC identifers: GC02P236925 GC02P237558 GC02P239256 GC02P238751 GC02P238634 GC02P230761


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCLY Gene:
Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of
L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 (PubMed 10692412)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for SCLY Gene: 
SCLY (selenocysteine lyase) is a protein-coding gene. Diseases associated with SCLY include lung adenocarcinoma, and glomerulonephritis, and among its related super-pathways are Metabolism. GO annotations related to this gene include pyridoxal phosphate binding and selenocysteine lyase activity. An important paralog of this gene is NFS1.

UniProtKB/Swiss-Prot: SCLY_HUMAN, Q96I15
Function: Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005120.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCLY gene promoter:
         AP-1   ATF-2   Lmo2   FOXD1   GATA-1   AREB6   MZF-1   c-Jun   Zic3   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCLY promoter sequence
   Search SABiosciences Chromatin IP Primers for SCLY

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCLY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

SCLY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCLY gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P238985:  view genomic region     (about GC identifiers)

Start:
238,969,530 bp from pter      End:
239,008,054 bp from pter
Size:
38,525 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SCLY_HUMAN, Q96I15 (See protein sequence)
Recommended Name: Selenocysteine lyase  
Size: 445 amino acids; 48149 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm, cytosol (By similarity)
Sequence caution: Sequence=BAA91659.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for SCLY:
3GZC (3D)        3GZD (3D)    
Secondary accessions: B9A068 J3KN06 Q53SN1 Q53SN8 Q7L670 Q9NVT7 Q9NZR7
Alternative splicing: 2 isoforms:  Q96I15-1   Q96I15-2   

Explore the universe of human proteins at neXtProt for SCLY: NX_Q96I15

Explore proteomics data for SCLY at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96I15

  • 4/6 DME Specific Peptides for SCLY (Q96I15) (see all 6)
     DYNATTP  RDYLEERL  EAWGNPSS  VTFVPVSKV 

    SCLY Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCLY Protein Expression
    REFSEQ proteins: NP_057594.4  
    ENSEMBL proteins: 
     ENSP00000254663   ENSP00000414165   ENSP00000391361   ENSP00000387162   ENSP00000392517  
     ENSP00000416344   ENSP00000406710   ENSP00000404473   ENSP00000402078   ENSP00000404444  
     ENSP00000414053   ENSP00000405907   ENSP00000401401   ENSP00000450613   ENSP00000416865  
     ENSP00000393694   ENSP00000362429  

    Human Recombinant Protein Products for SCLY: 
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    Sino Biological Recombinant Protein for SCLY
    Sino Biological Cell Lysate for SCLY 
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    Cloud-Clone Corp. Proteins for SCLY 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--

    SCLY for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for SCLY


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR015424 PyrdxlP-dep_Trfase
     IPR000192 Aminotrans_V/Cys_dSase
     IPR016454 Cysteine_dSase_NifS
     IPR015421 PyrdxlP-dep_Trfase_major_sub1
     IPR015422 PyrdxlP-dep_Trfase_major_sub2

    Graphical View of Domain Structure for InterPro Entry Q96I15

    ProtoNet protein and cluster: Q96I15

    1 Blocks protein domain: IPB000192 Aminotransferase

    UniProtKB/Swiss-Prot: SCLY_HUMAN, Q96I15
    Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family


    SCLY for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCLY_HUMAN, Q96I15
    Function: Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium (By similarity)
    Catalytic activity: L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor
    Induction: Up-regulated in acute glomerulonephritis. Regulated by JUN/AP-1

         Enzyme Number (IUBMB): EC 4.4.1.161 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0009000selenocysteine lyase activity IEA--
    GO:0016740transferase activity IEA--
    GO:0016829lyase activity ----
    GO:0030170pyridoxal phosphate binding IEA--
         
    SCLY for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Scly):
     behavior/neurological 

    SCLY for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCLY 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCLY 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SCLY About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins
    3Selenocompound metabolism
    Selenocompound metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SCLY
        Selenium Metabolism and Selenoproteins



    2         Kegg Pathways  (Kegg details for SCLY):
        Selenocompound metabolism
    Metabolic pathways


    SCLY for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCLY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for SCLY (Q96I153 ENSP000002546634) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    LNX2Q8N4483I2D: score=1 
    CTHENSP000003599764STRING: ENSP00000359976
    SEPHS1ENSP000003678934STRING: ENSP00000367893
    TXNRD1ENSP000004120454STRING: ENSP00000412045
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process TAS10692412
    GO:0008152metabolic process ----

    SCLY for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCLY for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCLY

    4 HMDB Compounds for SCLY    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hydrogen selenideDihydrogen monoselenide (see all 7)----
    L-Alanine(2S)-2-Aminopropanoate (see all 35)56-41-7--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    1 DrugBank Compound for SCLY    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor17139284 17016423 10592235

    3 Novoseek inferred chemical compound relationships for SCLY gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenocysteine 87.1 10 1483038 (2), 15534230 (1), 10692412 (1), 15953869 (1)
    selenium 62.5 5 1483038 (2), 15534230 (1), 10692412 (1)
    alanine 38.3 3 1483038 (1), 10692412 (1)

    Search CenterWatch for drugs/clinical trials and news about SCLY

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCLY gene: 
    NM_016510.5  

    Unigene Cluster for SCLY:

    Selenocysteine lyase
    Hs.731909  [show with all ESTs]
    Unigene Representative Sequence: AB209458
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000254663(uc010fyv.3 uc010znr.2 uc010znq.2) ENST00000480357
    ENST00000497256 ENST00000413463 ENST00000446202 ENST00000409736 ENST00000423324
    ENST00000412508 ENST00000443532 ENST00000416757 ENST00000487197 ENST00000480859
    ENST00000482031 ENST00000431487 ENST00000437134 ENST00000497951 ENST00000450965
    ENST00000440143
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SCLY
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    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCLY
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCLY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCLY
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCLY
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCLY

    Additional mRNA sequence: 

    AB209458.2 AF175767.1 AK001377.1 AK127520.1 AK293283.1 AK298409.1 AK301009.1 BC000586.2 
    BC007891.2 BC018966.2 

    11 DOTS entries:

    DT.95161160  DT.206965  DT.95161164  DT.91745044  DT.70103021  DT.101960273  DT.444590  DT.100825713 
    DT.70102676  DT.97808648  DT.97799220 

    24/318 AceView cDNA sequences (see all 318):

    BQ962765 BM142247 CR610086 AW204367 AI142222 AI139363 CR615230 BX117784 
    AF310723 AI791644 AA384235 BU689854 BM922883 BE018479 CF528949 AI272802 
    AA806862 AI688376 AW628238 CA413036 CB123239 BM793135 CR597637 BU633895 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SCLY (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
    SP1:                                      -                 -                 -                       -                       -                 -     -         
    SP2:                                                                                                  -                       -                 -     -         
    SP3:                                                        -                 -                       -                                                         
    SP4:                                                        -                 -                                                                                 
    SP5:                                      -           -     -     -     -     -                       -                                                         

    ExUns: 14a · 14b ^ 15a · 15b
    SP1:  -                     
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SCLY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCLY expression in normal human tissues (normalized intensities)      SCLY embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGATTTTGA
    SCLY Expression
    About this image


    SCLY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             brain/hindbrain   
     
     Neuron (Nervous System)
             nerve   
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Spinal Cord (Nervous System)

     -- (Nervous System)
             mouse/organ system/nervous system/central nervous system   

    See SCLY Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCLY

    SOURCE GeneReport for Unigene cluster: Hs.731909
        SABiosciences Custom PCR Arrays for SCLY
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCLY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SCLY gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scly1 , 5 selenocysteine lyase1, 5 82.05(n)1
    82.61(a)1
      1 (46.08 cM)5
    508801  NM_016717.31  NP_057926.21 
     912983385 
    chicken
    (Gallus gallus)
    Aves SCLY1 selenocysteine lyase 70.59(n)
    71.57(a)
      424739  NM_001139463.1  NP_001132935.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCLY6
    selenocysteine lyase
    62(a)
    1 ↔ 1
    3(35442129-35455723)
    zebrafish
    (Danio rerio)
    Actinopterygii scly1 selenocysteine lyase 63.21(n)
    63.37(a)
      559537  NM_001110383.1  NP_001103853.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F13H8.91 , 3 Nitrogen fixation (NIFS)3
    Protein F13H8.91
    42(a)3
    48.99(n)1
    46.35(a)1
      II(6279686-6280854)3
    1844401  NM_062857.21  NP_495258.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NFS16
    Cysteine desulfurase involved in iron-sulfur clust...
    30(a)
    1 → many
    III(92777-94270)


    ENSEMBL Gene Tree for SCLY (if available)
    TreeFam Gene Tree for SCLY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCLY gene
    NFS12  
    1 SIMAP similar gene for SCLY using alignment to 17 protein entries:     SCLY_HUMAN (see all proteins):
    NFS1

    SCLY for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    3 SNPs in SCLY are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0384664
    ----see VAR_0384662 F S mis40--------
    VAR_0384644
    ----see VAR_0384642 K E mis40--------
    VAR_0384654
    ----see VAR_0384652 A T mis40--------

    HapMap Linkage Disequilibrium report for SCLY (238969530 - 239008054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SCLY:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721746CNV Deletion23290073
    nsv508894CNV Insertion20534489
    esv1081669CNV Insertion17803354
    nsv876062CNV Loss21882294
    dgv4460n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611056    OMIM disorders: --

    8 diseases for SCLY:    About MalaCards
    lung adenocarcinoma    glomerulonephritis    pneumonia    hepatitis c
    tuberculosis    adenocarcinoma    hepatocellular carcinoma    hepatitis


    SCLY for disorders           About GeneDecksing

    Genetic Association Database (GAD): SCLY
    Human Genome Epidemiology (HuGE) Navigator: SCLY (1 document)

    Export disorders for SCLY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCLY gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SCLY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase. Candidate for selenium delivery protein in selenoprotein synthesis. (PubMed id 10692412)1, 2, 3, 9 Mihara H.... Esaki N. (2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Characterization of selenocysteine lyase in human tissues and its relationship to tissue selenium concentrations. (PubMed id 1483038)1, 9 Daher R. and Van Lente F. (1992)
    5. Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase . (PubMed id 22295093)1 Collins R....Hogbom M. (2012)
    6. Biochemical discrimination between selenium and sulfur 2: mechanistic investigation of the selenium specificity of human selenocystein e lyase. (PubMed id 22291978)1 Johansson A.L....Hogbom M. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51540 HGNC: 18161 AceView: SCLYandNCE2 Ensembl:ENSG00000132330 euGenes: HUgn51540
    ECgene: SCLY Kegg: 51540 H-InvDB: SCLY

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCLY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCLY gene:
    Search GeneIP for patents involving SCLY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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