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SCLY Gene

protein-coding   GIFtS: 57
GCID: GC02P238985

Selenocysteine Lyase

  Search for SCLY
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Selenocysteine Lyase1 2
SCL2 3 5
hSCL2 3
EC 4.4.1.163 8
Putative Selenocysteine Lyase1

External Ids:    HGNC: 181611   Entrez Gene: 515402   Ensembl: ENSG000001323307   OMIM: 6110565   UniProtKB: Q96I153   

Export aliases for SCLY gene to outside databases

Previous GC identifers: GC02P236925 GC02P237558 GC02P239256 GC02P238751 GC02P238634 GC02P230761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCLY Gene:
Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of
L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 (PubMed 10692412)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for SCLY Gene:
SCLY (selenocysteine lyase) is a protein-coding gene. GO annotations related to this gene include pyridoxal phosphate binding and selenocysteine lyase activity. An important paralog of this gene is ENSG00000272897.

UniProtKB/Swiss-Prot: SCLY_HUMAN, Q96I15
Function: Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SCLY gene promoter:
         AP-1   ATF-2   Lmo2   FOXD1   GATA-1   AREB6   MZF-1   c-Jun   Zic3   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCLY promoter sequence
   Search Chromatin IP Primers for SCLY

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCLY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

SCLY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCLY gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P238985:  view genomic region     (about GC identifiers)

Start:
238,969,530 bp from pter      End:
239,008,054 bp from pter
Size:
38,525 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SCLY_HUMAN, Q96I15 (See protein sequence)
Recommended Name: Selenocysteine lyase  
Size: 445 amino acids; 48149 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer (By similarity)
Sequence caution: Sequence=BAA91659.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for SCLY:
3GZC (3D)        3GZD (3D)    
Secondary accessions: B9A068 J3KN06 Q53SN1 Q53SN8 Q7L670 Q9NVT7 Q9NZR7
Alternative splicing: 2 isoforms:  Q96I15-1   Q96I15-2   

Explore the universe of human proteins at neXtProt for SCLY: NX_Q96I15

Explore proteomics data for SCLY at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys307, Lys341
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SCLY (Q96I15) (see all 6)
     DYNATTP  RDYLEERL  EAWGNPSS  VTFVPVSKV 


    See SCLY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057594.4  
    ENSEMBL proteins: 
     ENSP00000254663   ENSP00000414165   ENSP00000391361   ENSP00000387162   ENSP00000392517  
     ENSP00000416344   ENSP00000406710   ENSP00000404473   ENSP00000402078   ENSP00000404444  
     ENSP00000414053   ENSP00000405907   ENSP00000401401   ENSP00000450613   ENSP00000416865  
     ENSP00000393694   ENSP00000362429  

    SCLY Human Recombinant Protein Products:

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    Novus Biologicals SCLY Proteins
    Novus Biologicals SCLY Lysates
    Sino Biological Recombinant Protein for SCLY
    Sino Biological Cell Lysate for SCLY
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    Cloud-Clone Corp. Proteins for SCLY

     
    Search eBioscience for Proteins for SCLY 

    SCLY Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SCLY

    SCLY Assay Products:

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    Cloud-Clone Corp. ELISAs for SCLY
    Cloud-Clone Corp. CLIAs for SCLY
    Search eBioscience for ELISAs for SCLY 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR016454 Cysteine_dSase_NifS
     IPR015422 PyrdxlP-dep_Trfase_major_sub2
     IPR015424 PyrdxlP-dep_Trfase
     IPR000192 Aminotrans_V/Cys_dSase
     IPR015421 PyrdxlP-dep_Trfase_major_sub1

    Graphical View of Domain Structure for InterPro Entry Q96I15

    ProtoNet protein and cluster: Q96I15

    1 Blocks protein domain: IPB000192 Aminotransferase

    UniProtKB/Swiss-Prot: SCLY_HUMAN, Q96I15
    Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family


    Find genes that share domains with SCLY           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCLY_HUMAN, Q96I15
    Function: Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium (By similarity)
    Catalytic activity: L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor
    Induction: Up-regulated in acute glomerulonephritis. Regulated by JUN/AP-1

         Enzyme Number (IUBMB): EC 4.4.1.161 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0009000selenocysteine lyase activity IEA--
    GO:0016740transferase activity IEA--
    GO:0016829lyase activity ----
    GO:0030170pyridoxal phosphate binding IEA--
         
    Find genes that share ontologies with SCLY           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Scly):
     behavior/neurological 

    Find genes that share phenotypes with SCLY           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCLY
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    miRNA
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    miRTarBase miRNAs that target SCLY:
    hsa-mir-375 (MIRT020017), hsa-mir-92a-3p (MIRT049587), hsa-mir-193b-3p (MIRT041424)

    Block miRNA regulation of human, mouse, rat SCLY using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SCLY
    SwitchGear 3'UTR luciferase reporter plasmidSCLY 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SCLY

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    GenScript: all cDNA clones in your preferred vector: SCLY (NM_016510)
    Sino Biological Human cDNA Clone for SCLY
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCLY

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCLY


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCLY_HUMAN, Q96I15: Cytoplasm, cytosol (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--

    Find genes that share ontologies with SCLY           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SCLY About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Selenocompound metabolism
    Selenocompound metabolism
    3Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins


    Find genes that share SuperPaths with SCLY           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SCLY
        Selenium Metabolism and Selenoproteins



    2 Kegg Pathways  (Kegg details for SCLY):
        Selenocompound metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCLY
    Interactions:

        Search GeneGlobe Interaction Network for SCLY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SCLY (Q96I153 ENSP000002546634) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    LNX2Q8N4483I2D: score=1 
    CTHENSP000003599764STRING: ENSP00000359976
    SEPHS1ENSP000003678934STRING: ENSP00000367893
    TXNRD1ENSP000004120454STRING: ENSP00000412045
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process TAS10692412
    GO:0008152metabolic process ----

    Find genes that share ontologies with SCLY           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCLY

    4 HMDB Compounds for SCLY    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hydrogen selenideDihydrogen monoselenide (see all 7)----
    L-Alanine(2S)-2-Aminopropanoate (see all 35)56-41-7--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    1 DrugBank Compound for SCLY    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor17139284 17016423 10592235

    3 Novoseek inferred chemical compound relationships for SCLY gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenocysteine 87.1 10 1483038 (2), 15534230 (1), 10692412 (1), 15953869 (1)
    selenium 62.5 5 1483038 (2), 15534230 (1), 10692412 (1)
    alanine 38.3 3 1483038 (1), 10692412 (1)



    Find genes that share compounds with SCLY           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCLY gene: 
    NM_016510.5  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000254663(uc010fyv.3 uc010znr.2 uc010znq.2) ENST00000480357
    ENST00000497256 ENST00000413463 ENST00000446202 ENST00000409736 ENST00000423324
    ENST00000412508 ENST00000443532 ENST00000416757 ENST00000487197 ENST00000480859
    ENST00000482031 ENST00000431487 ENST00000437134 ENST00000497951 ENST00000450965
    ENST00000440143
    miRNA
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SCLY
      QuantiFast Probe-based Assays in human, mouse, rat SCLY

    Selected AceView cDNA sequences (see all 318):

    AI688377 AI082068 BX117784 AI792322 AI123897 BU689854 BG818765 AA243769 
    W60600 BQ962765 CK819837 BQ636945 BM922883 AW204367 BE855458 AI791644 
    NM_080678 AI272802 AI688376 CB123239 CA413036 CF528949 BE018479 CR605720 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SCLY (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
    SP1:                                      -                 -                 -                       -                       -                 -     -         
    SP2:                                                                                                  -                       -                 -     -         
    SP3:                                                        -                 -                       -                                                         
    SP4:                                                        -                 -                                                                                 
    SP5:                                      -           -     -     -     -     -                       -                                                         

    ExUns: 14a · 14b ^ 15a · 15b
    SP1:  -                     
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SCLY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCLY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGATTTTGA
    SCLY Expression
    About this image


    SCLY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Spinal Cord (Nervous System)
    SCLY Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCLY Protein Expression
        Custom PCR Arrays for SCLY
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCLY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SCLY gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scly1 , 5 selenocysteine lyase1, 5 82.05(n)1
    82.61(a)1
      1 (46.08 cM)5
    508801  NM_016717.31  NP_057926.21 
     912983385 
    chicken
    (Gallus gallus)
    Aves SCLY1 selenocysteine lyase 70.59(n)
    71.57(a)
      424739  NM_001271525.1  NP_001258454.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCLY6
    selenocysteine lyase
    62(a)
    1 ↔ 1
    3(35442129-35455723)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia scly1 selenocysteine lyase 62.51(n)
    66.17(a)
      496582  NM_001011164.1  NP_001011164.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scly1 selenocysteine lyase 63.21(n)
    63.37(a)
      559537  NM_001110383.1  NP_001103853.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Qtzl6
    Quetzalcoatl
    22(a)
    1 ↔ 1
    2L(11995751-11996723)
    worm
    (Caenorhabditis elegans)
    Secernentea F13H8.91 , 3 Nitrogen fixation (NIFS)3
    F13H8.91
    42(a)3
    48.64(n)1
    45.91(a)1
      II(6279686-6280854)3
    1844401  NM_062857.31  NP_495258.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NFS16
    Cysteine desulfurase involved in iron-sulfur clust...
    29(a)
    1 → many
    III(92777-94270) YCL017C


    ENSEMBL Gene Tree for SCLY (if available)
    TreeFam Gene Tree for SCLY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCLY gene
    ENSG000002728972  NFS12  
    1 SIMAP similar gene for SCLY using alignment to 17 protein entries:     SCLY_HUMAN (see all proteins):
    NFS1

    Find genes that share paralogs with SCLY           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for SCLY    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356373071,2,4
    ----see VAR_0384662 mis40--------
    rs75973671,2,4
    ----see VAR_0384642 mis40--------
    rs32104001,2,4
    ----see VAR_0384652 mis40--------

    HapMap Linkage Disequilibrium report for SCLY (238969530 - 239008054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SCLY:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721746CNV Deletion23290073
    nsv508894CNV Insertion20534489
    esv1081669CNV Insertion17803354
    nsv876062CNV Loss21882294
    dgv4460n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCLY
    DNA2.0 Custom Variant and Variant Library Synthesis for SCLY

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611056    OMIM disorders: --


    Find genes that share disorders with SCLY           About GenesLikeMe

    Genetic Association Database (GAD): SCLY
    Human Genome Epidemiology (HuGE) Navigator: SCLY (1 document)

    Export disorders for SCLY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCLY gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with SCLY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase. Candidate for selenium delivery protein in selenoprotein synthesis. (PubMed id 10692412)1, 2, 3, 9 Mihara H.... Esaki N. (J. Biol. Chem. 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Characterization of selenocysteine lyase in human tissues and its relationship to tissue selenium concentrations. (PubMed id 1483038)1, 9 Daher R. and Van Lente F. (J Trace Elem Electrolytes Health Dis 1992)
    5. Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase. (PubMed id 22295093)1 Collins R....HAPgbom M. (PLoS ONE 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Biochemical discrimination between selenium and sulfur 2: mechanistic investigation of the selenium specificity of human selenocysteine lyase. (PubMed id 22291978)1 Johansson A.L....HAPgbom M. (PLoS ONE 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51540 HGNC: 18161 AceView: SCLYandNCE2 Ensembl:ENSG00000132330 euGenes: HUgn51540
    ECgene: SCLY Kegg: 51540 H-InvDB: SCLY

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCLY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCLY gene:
    Search GeneIP for patents involving SCLY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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