Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SCLT1 Gene

protein-coding   GIFtS: 44
GCID: GC04M129805

Sodium Channel And Clathrin Linker 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sodium Channel And Clathrin Linker 11 2
Sodium Channel-Associated Protein 12 3
CAP1A2 5
CAP-1A2
hCAP-1A2
SAP13

External Ids:    HGNC: 264061   Entrez Gene: 1323202   Ensembl: ENSG000001514667   OMIM: 6113995   UniProtKB: Q96NL63   

Export aliases for SCLT1 gene to outside databases

Previous GC identifers: GC04M130024 GC04M125535


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SCLT1 Gene:
SCLT1 acts as a linker protein between the voltage-gated sodium channel Na(v)1.8 (SCN10A; MIM 604427) and clathrin
(see CLTC, MIM 118955) (Liu et al., 2005 (PubMed 15797711)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SCLT1 Gene:
SCLT1 (sodium channel and clathrin linker 1) is a protein-coding gene. GO annotations related to this gene include clathrin binding and protein C-terminus binding.

UniProtKB/Swiss-Prot: SCLT1_HUMAN, Q96NL6
Function: Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting
channel internalization (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCLT1 gene promoter:
         HFH-3   Sox5   Evi-1   C/EBPalpha   FOXI1   CREB   Pax-3   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCLT1 promoter sequence
   Search Chromatin IP Primers for SCLT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCLT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.2   Ensembl cytogenetic band:  4q28.2   HGNC cytogenetic band: 4q28.2

SCLT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCLT1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M129805:  view genomic region     (about GC identifiers)

Start:
129,786,076 bp from pter      End:
130,014,764 bp from pter
Size:
228,689 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SCLT1_HUMAN, Q96NL6 (See protein sequence)
Recommended Name: Sodium channel and clathrin linker 1  
Size: 688 amino acids; 80910 Da
Subunit: Interacts with SCN10A and clathrin. Identified in a complex containing SCN10A, clathrin and SCLT1 (By
similarity)
Secondary accessions: A4QN04 Q0VAH2 Q6P2M4
Alternative splicing: 4 isoforms:  Q96NL6-1   Q96NL6-2   Q96NL6-3   Q96NL6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCLT1: NX_Q96NL6

Explore proteomics data for SCLT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SCLT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653244.2  
    ENSEMBL proteins: 
     ENSP00000281142   ENSP00000395292   ENSP00000424029   ENSP00000424304   ENSP00000420861  
     ENSP00000425315   ENSP00000401539  

    SCLT1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SCLT1
    GenScript Custom Purified and Recombinant Proteins Services for SCLT1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCLT1

     
    Search eBioscience for Proteins for SCLT1 

     
    Search antibodies-online for proteins for SCLT1 

     
    antibodies-online peptides for SCLT1

    SCLT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SCLT1
    Novus Biologicals SCLT1 Antibody
    Abcam antibodies for SCLT1
    Cloud-Clone Corp. Antibodies for SCLT1
    Search ThermoFisher Antibodies for SCLT1
    antibodies-online antibodies for SCLT1 (26 products) 

    SCLT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SCLT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCLT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCLT1
    Cloud-Clone Corp. CLIAs for SCLT1
    Search eBioscience for ELISAs for SCLT1 
    antibodies-online kits for SCLT1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus

    ProtoNet protein and cluster: Q96NL6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCLT1_HUMAN, Q96NL6
    Function: Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting
    channel internalization (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008022protein C-terminus binding IEA--
    GO:0017080sodium channel regulator activity IEA--
    GO:0030276clathrin binding IEA--
         
    Find genes that share ontologies with SCLT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SCLT1:
     Proliferating cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SCLT1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SCLT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCLT1 (see all 12):
    hsa-miR-600 hsa-miR-554 hsa-miR-181a-2* hsa-miR-3647-3p hsa-miR-373* hsa-miR-519e* hsa-miR-515-5p hsa-miR-127-5p
    SwitchGear 3'UTR luciferase reporter plasmidSCLT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SCLT1
    Predesigned siRNA for gene silencing in human, mouse, rat SCLT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCLT1

    Clone
    Products:
         
    OriGene clones in human, mouse for SCLT1 (see all 7)
    OriGene ORF clones in mouse, rat for SCLT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCLT1 (NM_144643)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCLT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCLT1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SCLT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SCLT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCLT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SCLT1_HUMAN, Q96NL6: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
    Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma
    membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005814centriole IDA--
    GO:0015630microtubule cytoskeleton IDA--
    GO:0045111intermediate filament cytoskeleton ----

    Find genes that share ontologies with SCLT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCLT1
    Interactions:

        Search GeneGlobe Interaction Network for SCLT1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for SCLT1 (Q96NL63 ENSP000002811424) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    SCN10AQ9Y5Y93, ENSP000003906004I2D: score=1 STRING: ENSP00000390600
    AMOTQ4VCS53, ENSP000003610274I2D: score=2 STRING: ENSP00000361027
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042384cilium assembly IMP--
    GO:0045162clustering of voltage-gated sodium channels IEA--

    Find genes that share ontologies with SCLT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCLT1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SCLT1 gene: 
    NM_144643.2  

    Unigene Cluster for SCLT1:

    Sodium channel and clathrin linker 1
    Hs.654690  [show with all ESTs]
    Unigene Representative Sequence: AK122852
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503565 ENST00000281142(uc003igo.2 uc003igp.2) ENST00000506233(uc003ign.2)
    ENST00000439369 ENST00000503215 ENST00000502495 ENST00000506368(uc003igr.2)
    ENST00000511426(uc003igt.4) ENST00000503401 ENST00000434680(uc003igq.2 uc010iob.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCLT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCLT1 (see all 12):
    hsa-miR-600 hsa-miR-554 hsa-miR-181a-2* hsa-miR-3647-3p hsa-miR-373* hsa-miR-519e* hsa-miR-515-5p hsa-miR-127-5p
    SwitchGear 3'UTR luciferase reporter plasmidSCLT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SCLT1
    Predesigned siRNA for gene silencing in human, mouse, rat SCLT1
    Clone
    Products:
         
    OriGene clones in human, mouse for SCLT1 (see all 7)
    OriGene ORF clones in mouse, rat for SCLT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCLT1 (NM_144643)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCLT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCLT1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SCLT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCLT1
      QuantiTect SYBR Green Assays in human, mouse, rat SCLT1
      QuantiFast Probe-based Assays in human, mouse, rat SCLT1

    Additional mRNA sequence: 

    AK055217.1 AK093361.1 AK122852.1 BC014677.1 BC040258.1 BC064428.1 BC121057.1 BC121058.1 
    BC128051.1 

    8 DOTS entries:

    DT.100008308  DT.101973611  DT.101979600  DT.75175694  DT.97781756  DT.99927598  DT.121221744  DT.95367932 

    Selected AceView cDNA sequences (see all 59):

    AA553518 CR593773 BG206279 BC040258 AW083303 BG204665 C01427 AK055217 
    AW513286 AW770398 NM_144643 AX748077 BE890996 BG183864 AL579773 AI768586 
    BM924929 BF035693 BC064428 BM458389 AK093361 CD679143 BM836754 BP365420 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SCLT1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                -                                             
    SP2:                    -           -                                             
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for SCLT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SCLT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SCLT1 Expression
    About this image

    SCLT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCLT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654690
        Custom PCR Arrays for SCLT1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SCLT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCLT1
    QuantiTect SYBR Green Assays in human, mouse, rat SCLT1
    QuantiFast Probe-based Assays in human, mouse, rat SCLT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCLT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SCLT1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sclt11 , 5 sodium channel and clathrin linker 11, 5 82.61(n)1
    75.44(a)1
      3 (19.91 cM)5
    671611  NM_001081411.11  NP_001074880.11 
     416267175 
    chicken
    (Gallus gallus)
    Aves SCLT11 sodium channel and clathrin linker 1 68.43(n)
    60.87(a)
      422486  XM_420451.4  XP_420451.2 
    lizard
    (Anolis carolinensis)
    Reptilia SCLT16
    sodium channel and clathrin linker 1
    63(a)
    1 ↔ 1
    AAWZ02035000(5652-47670)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ052961.12   -- 70(n)    BJ052961.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sclt11 sodium channel and clathrin linker 1 56.27(n)
    49.71(a)
      561057  XM_005159813.1  XP_005159870.1 


    ENSEMBL Gene Tree for SCLT1 (if available)
    TreeFam Gene Tree for SCLT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SCLT1 gene
    Selected SIMAP similar genes for SCLT1 using alignment to 4 protein entries:     SCLT1_HUMAN (see all proteins) (see all similar genes):
    THADA    HGSNAT    IFT122    C12orf23    DAPK2    SUN3
    UTY    ATL2    CNOT2    FANCA    LRRC36    FAM3A
    SENP7    BUB1B    GNPTAB    SCIMP    NSD1    SERF1B

    Find genes that share paralogs with SCLT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SCLT1 (see all 3946)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709384471,2
    C--125633328(+) ATGAG-/AAAGTGA 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs1120683091,2
    C,F--129804707(+) AAATAC/TGATAA 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs3185001,2
    C,F,O,A,H--129804727(+) AAAAAG/AATTCC 1 -- ds50019Minor allele frequency- A:0.31NA CSA WA EA 503
    rs1841218271,2
    C--129804746(+) TCTTAA/TCTGTT 1 -- ds50010--------
    rs1875279271,2
    --129804754(+) GTTAGC/TACCAT 1 -- ds50010--------
    rs1394573421,2
    --129804794(+) CTACAC/TGTGAA 1 -- ds50010--------
    rs1914167991,2
    C--129804815(+) TCACCC/TTCAAC 1 -- ds50010--------
    rs170138981,2
    C,F,H--129804917(+) GGGTGC/TGCTAA 1 -- ds500118Minor allele frequency- T:0.05NA NS EA CSA WA 1953
    rs1839472201,2
    --129804929(+) TTCAAA/GCCAGA 1 -- ds50010--------
    rs771945681,2
    C--129805055(+) ACCTTA/CCAAAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SCLT1 (129786076 - 130014764 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SCLT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670641CNV Deletion23128226
    esv2656466CNV Deletion23128226
    nsv4505CNV Insertion18451855
    nsv879931CNV Loss21882294
    nsv522694CNV Loss19592680
    nsv517249CNV Gain19592680
    nsv822718CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCLT1
    DNA2.0 Custom Variant and Variant Library Synthesis for SCLT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611399    OMIM disorders: --


    Find genes that share disorders with SCLT1           About GenesLikeMe


    Export disorders for SCLT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SCLT1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SCLT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Na(v)1.8. (PubMed id 15797711)1, 3 Liu C....Dib-Hajj S.D. (Mol. Cell. Neurosci. 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Centriole distal appendages promote membrane docking, leading to cilia initiation. (PubMed id 23348840)2 Tanos B.E....Tsou M.F. (Genes Dev. 2013)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Biochemical and computational analysis of LNX1 interacting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (PLoS ONE 2011)
    6. Expanding the substantial interactome of NEMO using protein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (PLoS ONE 2010)
    7. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    10. Scanning the human proteome for calmodulin-binding proteins. (PubMed id 15840729)1 Shen X....Liu R. (Proc. Natl. Acad. Sci. U.S.A. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 132320 HGNC: 26406 AceView: FLJ30655 Ensembl:ENSG00000151466 euGenes: HUgn132320
    ECgene: SCLT1 H-InvDB: SCLT1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SCLT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SCLT1 gene:
    Search GeneIP for patents involving SCLT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SCLT1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SCLT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SCLT1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SCLT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCLT1   OriGene Custom Protein Services for SCLT1  

     
     
     Block miRNA regulation of human, mouse, rat SCLT1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SCLT1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCLT1 Predesigned siRNA for gene silencing in human, mouse, rat SCLT1
     QuantiFast Probe-based Assays in human, mouse, rat SCLT1 QuantiTect SYBR Green Assays in human, mouse, rat SCLT1
     Custom PCR Arrays for SCLT1 Search Chromatin IP Primers for SCLT1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCLT1  Search GeneGlobe Interaction Network for SCLT1
     Regulatory tfbs in SCLT1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SCLT1 GenScript cDNA clones with any tag delivered in your preferred vector for SCLT1
     GenScript Custom Assay Services for SCLT1 GenScript Custom overexpressing Cell Line Services for SCLT1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SCLT1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SCLT1 antibodies
     Antibodies for SCLT1
     See all of Abcam's Antibodies, Kits and Proteins for SCLT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SCLT1
     Antibodies for SCLT1
     ELISAs for SCLT1
     CLIAs for SCLT1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SCLT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCLT1
     SwitchGear 3'UTR luciferase reporter plasmids for SCLT1
     SwitchGear Promoter luciferase reporter plasmids for SCLT1
     Search ThermoFisher Antibodies for SCLT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCLT1
     Browse compounds at ApexBio
     Search Addgene for plasmids for SCLT1
      Search eBioscience for proteins for SCLT1
      Search eBioscience for elisas for SCLT1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SCLT1
     antibodies-online antibodies for SCLT1 (26 products)
     antibodies-online kits for SCLT1 (4 products)
     antibodies-online peptides for SCLT1
      Search antibodies-online for proteins for SCLT1
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SCLT1 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4