External Ids for SCIN Gene
SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]
GeneCards Summary for SCIN Gene
SCIN (Scinderin) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Endochondral Ossification. GO annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is AVIL.
UniProtKB/Swiss-Prot for SCIN Gene
Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).