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Aliases for SCIN Gene

Aliases for SCIN Gene

  • Scinderin 2 3 4
  • KIAA1905 4 6
  • Adseverin 3

External Ids for SCIN Gene

Summaries for SCIN Gene

Entrez Gene Summary for SCIN Gene

  • SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]

GeneCards Summary for SCIN Gene

SCIN (Scinderin) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Endochondral Ossification. GO annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is AVIL.

UniProtKB/Swiss-Prot for SCIN Gene

  • Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).

Gene Wiki entry for SCIN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCIN Gene

Genomics for SCIN Gene

Genomic Location for SCIN Gene

Start:
12,570,577 bp from pter
End:
12,653,603 bp from pter
Size:
83,027 bases
Orientation:
Plus strand

Genomic View for SCIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCIN Gene

Regulatory Elements for SCIN Gene

Proteins for SCIN Gene

  • Protein details for SCIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6U3-ADSV_HUMAN
    Recommended name:
    Adseverin
    Protein Accession:
    Q9Y6U3
    Secondary Accessions:
    • A8K2U8
    • Q8NBZ6
    • Q8WU97
    • Q96JC7
    • Q96PY2

    Protein attributes for SCIN Gene

    Size:
    715 amino acids
    Molecular mass:
    80489 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB67798.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCIN Gene

    Alternative splice isoforms for SCIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCIN Gene

Proteomics data for SCIN Gene at MOPED

Post-translational modifications for SCIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCIN Gene

Domains for SCIN Gene

UniProtKB/Swiss-Prot:

ADSV_HUMAN
Family:
  • Belongs to the villin/gelsolin family.:
    • Q9Y6U3
Similarity:
  • Contains 6 gelsolin-like repeats.:
    • Q9Y6U3
genes like me logo Genes that share domains with SCIN: view

No data available for Gene Families for SCIN Gene

Function for SCIN Gene

Molecular function for SCIN Gene

UniProtKB/Swiss-Prot Function: Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).

Gene Ontology (GO) - Molecular Function for SCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding ISS --
GO:0003779 actin binding TAS 11568009
GO:0005509 calcium ion binding TAS 11568009
GO:0005545 1-phosphatidylinositol binding TAS 11568009
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS --
genes like me logo Genes that share ontologies with SCIN: view

miRNA for SCIN Gene

miRTarBase miRNAs that target SCIN

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCIN Gene

Localization for SCIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCIN Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCIN Gene COMPARTMENTS Subcellular localization image for SCIN gene
Compartment Confidence
cytoskeleton 5
cytosol 4
extracellular 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005856 cytoskeleton IEA --
GO:0005938 cell cortex ISS --
GO:0043234 protein complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SCIN: view

Pathways for SCIN Gene

genes like me logo Genes that share pathways with SCIN: view

Pathways by source for SCIN Gene

Gene Ontology (GO) - Biological Process for SCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IMP 11568009
GO:0017156 calcium ion-dependent exocytosis ISS --
GO:0032330 regulation of chondrocyte differentiation ISS --
GO:0042989 sequestering of actin monomers IMP 19666531
GO:0043065 positive regulation of apoptotic process IMP 11568009
genes like me logo Genes that share ontologies with SCIN: view

Compounds for SCIN Gene

(124) HMDB Compounds for SCIN Gene

Compound Synonyms Cas Number PubMed IDs
PS(14:0/14:0)
  • Phosphatidylserine(14:0/14:0)
Not Available
PS(14:0/14:1(9Z))
  • Phosphatidylserine(14:0/14:1n5)
Not Available
PS(14:0/16:0)
  • 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
Not Available
PS(14:0/16:1(9Z))
  • PS(14:0/16:1n7)
Not Available
PS(14:0/18:0)
  • Phosphatidylserine(32:0)
Not Available

(7) Novoseek inferred chemical compound relationships for SCIN Gene

Compound -log(P) Hits PubMed IDs
pip2 71.2 5
digitonin 55.5 7
catecholamine 53.6 8
calcium 35.3 22
nicotine 29.6 5
genes like me logo Genes that share compounds with SCIN: view

Transcripts for SCIN Gene

Unigene Clusters for SCIN Gene

Scinderin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCIN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - -
SP6: -
SP7: -
SP8: -

ExUns: 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SCIN Gene

GeneLoc Exon Structure for
SCIN
ECgene alternative splicing isoforms for
SCIN

Expression for SCIN Gene

mRNA expression in normal human tissues for SCIN Gene

mRNA differential expression in normal tissues according to GTEx for SCIN Gene

This gene is overexpressed in Kidney - Cortex (7.1), Brain - Spinal cord (cervical c-1) (5.2), Esophagus - Mucosa (4.3), Small Intestine - Terminal Ileum (4.2), and Colon - Transverse (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCIN Gene

SOURCE GeneReport for Unigene cluster for SCIN Gene Hs.655515

genes like me logo Genes that share expressions with SCIN: view

Orthologs for SCIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCIN 36
  • 99.16 (n)
  • 99.44 (a)
SCIN 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCIN 36
  • 88.8 (n)
  • 90.34 (a)
SCIN 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCIN 36
  • 90.19 (n)
  • 92.72 (a)
mouse
(Mus musculus)
Mammalia Scin 36
  • 86.81 (n)
  • 91.47 (a)
Scin 16
Scin 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCIN 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCIN 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scin 36
  • 86.71 (n)
  • 91.61 (a)
chicken
(Gallus gallus)
Aves SCIN 36
  • 76.55 (n)
  • 80.7 (a)
SCIN 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCIN 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495760 36
  • 72.3 (n)
  • 74.23 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6995 36
zebrafish
(Danio rerio)
Actinopterygii scin 36
  • 68.12 (n)
  • 71.59 (a)
scin 37
  • 70 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6001 37
  • 42 (a)
OneToMany
Species with no ortholog for SCIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCIN Gene

ENSEMBL:
Gene Tree for SCIN (if available)
TreeFam:
Gene Tree for SCIN (if available)

Paralogs for SCIN Gene

Paralogs for SCIN Gene

Selected SIMAP similar genes for SCIN Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SCIN: view

Variants for SCIN Gene

Sequence variations from dbSNP and Humsavar for SCIN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs11976 -- 12,588,962(-) accca(G/T)cctct intron-variant, upstream-variant-2KB
rs13202 -- 12,588,785(-) TTACC(C/T)TGAAT intron-variant, upstream-variant-2KB
rs14001 -- 12,588,935(-) CCTAT(C/T)CAGCA intron-variant, upstream-variant-2KB
rs702476 -- 12,598,342(+) TCCTT(C/G)TGCCA intron-variant
rs702477 -- 12,620,901(+) ACTGA(C/T)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCIN Gene

Variant ID Type Subtype PubMed ID
nsv528031 CNV Loss 19592680
nsv470066 CNV Loss 18288195
nsv464379 CNV Loss 19166990
nsv521176 CNV Gain 19592680
nsv527833 CNV Loss 19592680
nsv818483 CNV Gain 17921354
esv2596299 CNV Deletion 19546169
nsv524108 CNV Loss 19592680
dgv406n21 CNV Loss 19592680
nsv520866 CNV Loss 19592680
nsv519573 CNV Loss 19592680
nsv830907 CNV Loss 17160897

Relevant External Links for SCIN Gene

HapMap Linkage Disequilibrium report
SCIN

Disorders for SCIN Gene

(1) University of Copenhagen DISEASES for SCIN Gene

(1) Novoseek inferred disease relationships for SCIN Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for SCIN

Genetic Association Database (GAD)
SCIN
genes like me logo Genes that share disorders with SCIN: view

No data available for UniProtKB/Swiss-Prot for SCIN Gene

Publications for SCIN Gene

  1. The crystal structure of the C-terminus of adseverin reveals the actin-binding interface. (PMID: 19666531) Chumnarnsilpa S. … Robinson R.C. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  3. Ca2+ and pH determine the interaction of chromaffin cell scinderin with phosphatidylserine and phosphatidylinositol 4,5,-biphosphate and its cellular distribution during nicotinic-receptor stimulation and protein kinase C activation. (PMID: 1331119) RodrA-guez Del Castillo A. … TrifarA^ J.M. (J. Cell Biol. 1992) 3 23
  4. Barrier role of actin filaments in regulated mucin secretion from airway goblet cells. (PMID: 15342343) Ehre C. … Davis C.W. (Am. J. Physiol., Cell Physiol. 2005) 3 23
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for SCIN Gene

Sources for SCIN Gene

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