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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCIN Gene

protein-coding GIFtS: 59
GCID: GC07P012576

scinderin

Explore 4 diseases affiliated with
SCIN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Scinderin³
Scinderin³
KIAA1905¹ ³ ⁵
Adseverin¹

External Ids:	HGNC: 21695¹	Entrez Gene: 85477²	Ensembl: ENSG00000006747⁷	OMIM: 613416⁵	UniProtKB: Q9Y6U3³

Export aliases for SCIN gene to outside databases

Previous GC identifers: GC07P012254 GC07P012354 GC07P012383 GC07P012488

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCIN:

SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 (PubMed 11568009)).(supplied by

OMIM, May 2010)

UniProtKB/Swiss-Prot: ADSV_HUMAN, Q9Y6U3

Function: Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis

by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed

end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and

differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of

non-hypertrophic chondrocytes (By similarity)

Gene Wiki entry for SCIN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SCIN gene promoter:
AML1a Tal-1beta E47 FOXL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SCIN promoter sequence

Search SABiosciences Chromatin IP Primers for SCIN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCIN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3 Ensembl cytogenetic band: 7p21.3 HGNC cytogenetic band: 7p21.3

SCIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCIN gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P012576: view genomic region (about GC identifiers)

Start:	12,610,203 bp from pter	End:	12,693,228 bp from pter
Size:	83,026 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 12,661,354-12,744,363

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADSV_HUMAN, Q9Y6U3 (See protein sequence)

Recommended Name: Adseverin

Size: 715 amino acids; 80489 Da

Subcellular location: Cytoplasm, cytoskeleton

Sequence caution: Sequence=BAB67798.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for SCIN:

3FG6 (3D)

Secondary accessions: A8K2U8 Q8NBZ6 Q8WU97 Q96JC7 Q96PY2

Alternative splicing: 3 isoforms: Q9Y6U3-1 Q9Y6U3-2 Q9Y6U3-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCIN: NX_Q9Y6U3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y6U3

SCIN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001106177.1 NP_149119.1

ENSEMBL proteins:

ENSP00000341375 ENSP00000297029 ENSP00000404380 ENSP00000411149 ENSP00000429598

ENSP00000428555 ENSP00000430997 ENSP00000390189

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SCIN OriGene Protein Over-expression Lysate: SCIN OriGene Custom Protein Services for SCIN
	GenScript Custom Purified and Recombinant Proteins Services for SCIN
	Novus Biologicals SCIN Protein Novus Biologicals SCIN Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SCIN

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--
GO:0005856	cytoskeleton	IEA	--
GO:0005938	cell cortex	ISS	--

SCIN for ontologies About GeneDecksing

SCIN Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: SCIN OriGene Custom Antibody Services for SCIN
	GenScript Superior Antibodies for SCIN
	Novus Biologicals SCIN Antibodies
	Abcam antibodies for SCIN
	Uscn Antibodies for SCIN
	ThermoFisher Antibody for SCIN

Assay Products for SCIN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SCIN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SCIN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SCIN for domains About GeneDecksing

2 InterPro domains/families:

IPR007122 Gelsolin

IPR007123 Gelsolin_dom

Graphical View of Domain Structure for InterPro Entry Q9Y6U3

ProtoNet protein and cluster: Q9Y6U3

2 Blocks protein families:

IPB007122 Gelsolin family signature

IPB007123 Gelsolin region

UniProtKB/Swiss-Prot: ADSV_HUMAN, Q9Y6U3

Similarity: Belongs to the villin/gelsolin family

Similarity: Contains 6 gelsolin-like repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADSV_HUMAN, Q9Y6U3

Function: Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis

by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed

end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and

differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of

non-hypertrophic chondrocytes (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SCIN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCIN
		1 QIAGEN miScript miRNA Assays for microRNA that regulate SCIN:
		hsa-miR-3163
		SwitchGear 3'UTR luciferase reporter plasmid: SCIN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCIN (see all 7) OriGene shRNA RFP: SCIN OriGene siRNA: SCIN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCIN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SCIN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCIN (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCIN (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SCIN (NM_033128)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCIN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCIN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SCIN
		Search LifeMap BioReagents cell lines for SCIN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCIN

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001786	phosphatidylserine binding	ISS	--
GO:0003779	actin binding	TAS	11568009
GO:0005509	calcium ion binding	TAS	11568009
GO:0005545	1-phosphatidylinositol binding	TAS	11568009
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISS	--

SCIN for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Fc gamma R-mediated phagocytosis

Fc gamma R-mediated phagocytosis

1.00

Endochondral Ossification

Endochondral Ossification

1.00

Regulation of Actin Cytoskeleton

Regulation of actin cytoskeleton

0.58

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for SCIN

Endochondral Ossification

2 Kegg Pathways (Kegg details for SCIN):

	Fc gamma R-mediated phagocytosis
	Regulation of actin cytoskeleton

SCIN for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SCIN

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/14 Interacting proteins for SCIN (Q9Y6U3^{2, 3} ENSP00000297029⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP3K3	Q99759²^,³	MINT-48372 I2D: score=2
RIPK3	Q9Y572²^,³	MINT-49080 I2D: score=2
ACTA1	P68133³, ENSP00000355645⁴	I2D: score=1 STRING: ENSP00000355645
ACTC1	P68032³, ENSP00000290378⁴	I2D: score=1 STRING: ENSP00000290378
ACTG1	P63261³, ENSP00000331514⁴	I2D: score=1 STRING: ENSP00000331514

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008285	negative regulation of cell proliferation	IMP	11568009
GO:0017156	calcium ion-dependent exocytosis	ISS	--
GO:0032330	regulation of chondrocyte differentiation	ISS	--
GO:0043065	positive regulation of apoptotic process	IMP	11568009
GO:0045010	actin nucleation	ISS	--

SCIN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SCIN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SCIN

10/124 HMDB Compounds for SCIN (see all 124) About this table

Compound	Synonyms	CAS #	PubMed Ids
PS(14:0/14:0)	Phosphatidylserine(14:0/14:0) (see all 7)	--	--
PS(14:0/14:1(9Z))	Phosphatidylserine(14:0/14:1n5) (see all 13)	--	--
PS(14:0/16:0)	1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)	--	--
PS(14:0/16:1(9Z))	PS(14:0/16:1n7) (see all 13)	--	--
PS(14:0/18:0)	Phosphatidylserine(32:0) (see all 7)	--	--
PS(14:0/18:1(9Z))	PSer(14:0/18:1n9) (see all 13)	--	--
PS(14:0/18:2(9Z,12Z))	PS(14:0/18:2) (see all 13)	--	--
PS(14:0/18:3(9Z,12Z,15Z))	Phosphatidylserine(14:0/18:3) (see all 14)	--	--
PS(14:0/20:3(8Z,11Z,14Z))	PSer(14:0/20:3) (see all 14)	--	--
PS(14:0/20:4(5Z,8Z,11Z,14Z))	PS(34:4) (see all 13)	--	--

7 Novoseek chemical compound relationships for SCIN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pip2	71.2	7	8780652 (3), 8547642 (1), 10566943 (1)
digitonin	55.5	9	1402916 (6), 8547642 (1)
catecholamine	53.6	10	7643107 (3), 1645735 (2), 1402916 (2), 9226413 (1)
calcium	35.3	31	19666531 (3), 11158248 (3), 1402916 (3), 7643107 (2) (see all 12)
nicotine	29.6	5	7905766 (2), 1331119 (2), 1337454 (1)
phosphatidylinositol	18.2	1	9452496 (1)
histamine	13.6	3	7643107 (3)

Search CenterWatch for drugs/clinical trials and news about SCIN / ADSV

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCIN gene (2 alternative transcripts):

NM_001112706.2 NM_033128.3

Unigene Cluster for SCIN:

Scinderin

Hs.655515 [show with all ESTs]

Unigene Representative Sequence: AK023847

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341757 ENST00000297029(uc003ssn.4 uc010ktt.3) ENST00000417018

ENST00000436854 ENST00000523729 ENST00000518849 ENST00000519209(uc003sso.4)

ENST00000486980 ENST00000473722 ENST00000476649 ENST00000445618

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SCIN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCIN
		1 QIAGEN miScript miRNA Assays for microRNA that regulate SCIN:
		hsa-miR-3163
		SwitchGear 3'UTR luciferase reporter plasmid: SCIN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCIN (see all 7) OriGene shRNA RFP: SCIN OriGene siRNA: SCIN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCIN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCIN (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCIN (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SCIN (NM_033128)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCIN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCIN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCIN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SCIN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCIN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCIN

Additional cDNA sequence:

AB067492.1 AF276507.1 AK023847.1 AK027778.1 AK075123.1 AK075198.1 AK290363.1 BC021090.1

8 DOTS entries:

DT.430379 DT.91884272 DT.412157 DT.100692108 DT.75122151 DT.97838624 DT.87001203 DT.97822860

24/62 AceView cDNA sequences (see all 62):

CA447429 BX506250 BC075797 AI222285 BC021090 CB960454 BQ717662 BX113353

AI089017 AK075198 NM_033128 AK027778 BG400563 BU193785 AA297223 CA448540

AL699247 BG769997 BE897112 AI470271 CA427600 BG763010 BX479735 BU929734

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SCIN (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:					-		-										-		-		-				-
SP2:					-		-										-		-		-				-																				-
SP3:																			-		-				-
SP4:
SP5:																					-				-

ExUns:	22
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SCIN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCIN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGAGAAAA

About this image

SCIN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+BMP4-induced 4D20.8 cells (Chondrogenic inducti...)

Bone, Cartilage

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

HyStem+TGF?3+GDF5-induced 4D20.8 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See SCIN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCIN

SOURCE GeneReport for Unigene cluster: Hs.655515

SABiosciences Custom PCR Arrays for SCIN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCIN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SCIN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCIN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCIN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCIN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCIN gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SCIN¹	scinderin	76.55(n) 80.7(a)		420588 NM_001244593.1 NP_001231522.1
lizard (Anolis carolinensis)	Reptilia	SCIN⁶	--	78(a)	1 ↔ 1	6(25777261-25841321)
zebrafish (Danio rerio)	Actinopterygii	BC056544.1²	--	72.41(n)		BC056544.1
fruit fly (Drosophila melanogaster)	Insecta	Gel⁶ qua⁶	quail	32(a) 19(a)	possible ortholog 1 ↔ many	3R(60868-66780) 2L(17486806-17497203)
worm (Caenorhabditis elegans)	Secernentea	gsnl-1⁶	Gelsolin-like protein 1	38(a)	possible ortholog	V(9497027-9499354)
thale cress (Arabidopsis thaliana)	eudicotyledons	VLN3⁶ VLN2⁶ (see all 5)	villin 2 (see all 5)	24(a) 23(a) (see all 5)	possible ortholog possible ortholog (see all 5)	3(21243136-21251100) 2(17410715-17417740)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	villin protein, putative, expressed (see all 5)	30(a) 23(a) (see all 5)	possible ortholog possible ortholog (see all 5)	8(8507453-8515439) 4(30278742-30287878)

ENSEMBL Gene Tree for SCIN (if available)
TreeFam Gene Tree for SCIN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SCIN gene

SVIL² FLII² AVIL² VILL² GSN² VIL1² CAPG²

6 SIMAP similar genes for SCIN using alignment to 6 protein entries: ADSV_HUMAN (see all proteins):

GSN VIL1 AVIL CAPG VILL FLII

SCIN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7804260^1,2	C,F,A,H,	--	12608263(+)	`ATGAAG/AGTATT`	1	--	us2k¹		22		NS EA NA WA CSA	2157
rs74986632^1,2	F,	--	12608271(+)	`ATTCTC/GTGAAG`	1	--	us2k¹		1		EA	120
rs144519520^1,2		--	12608295(+)	`CTAAAC/GTCTCG`	1	--	us2k¹		0	--	--	--	--
rs77072000^1,2	C,	--	12608438(+)	`TCAGGC/ACACTG`	1	--	us2k¹		2		NA	122
rs181178001^1,2		--	12608487(+)	`TTTCTA/GACCCC`	1	--	us2k¹		0	--	--	--	--
rs114579185^1,2	F,	--	12608572(+)	`TTGGCC/AAATCA`	1	--	us2k¹		1		WA	118
rs78240404^1,2	F,	--	12608590(+)	`ATTCTC/ACCCCA`	1	--	us2k¹		1		WA	118
rs183754017^1,2		--	12608603(+)	`CCCGCG/TGATAA`	1	--	us2k¹		0	--	--	--	--
rs148429439^1,2		--	12608675(+)	`AGAGGA/GTAGAG`	1	--	us2k¹		0	--	--	--	--
rs75274887^1,2	F,	--	12608706(+)	`CTACAC/GTATGA`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for SCIN (12610203 - 12693228 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SCIN
2 CNVs: 99871 9560
1 Indel: 52075

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCIN for disorders           About GeneDecksing

OMIM gene information: 613416    OMIM disorders: --

4 diseases for SCIN:    About MalaCards

rothmund-thomson syndrome vesicoureteral reflux megakaryoblastic leukemia leukemia

1 disease from the University of Copenhagen DISEASES database for SCIN:

Vesicoureteral reflux

1 Novoseek disease relationship for SCIN gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	11568009 (1)

Export disorders for SCIN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SCIN gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with SCIN)

Utopia: connect your pdf to the dynamic
world of online information

The crystal structure of the C-terminus of adseverin reveals the actin-binding interface. (PubMed id 19666531)^{1, 2, 9} Chumnarnsilpa S....Robinson R.C. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)^{1, 2} Nagase T....Ohara O. (2001)
Ca2+ and pH determine the interaction of chromaffin cell scinderin with phosphatidylserine and phosphatidylinositol 4,5,-biphosphate and its cellular distribution during nicotinic-receptor stimulation and protein kinase C activation. (PubMed id 1331119)^{1, 9} Rodriguez Del Castillo A....Trifaro J.M. (1992)
Human platelets contain scinderin, a Ca(2+)-dependent actin filament-severing protein. (PubMed id 1621245)^{1, 9} Rodriguez Del Castillo A....Trifaro J.M. (1992)
Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis. (PubMed id 11568009)^{1, 9} Zunino R....Trifaro J.M. (2001)
The actin-binding proteins adseverin and gelsolin are both highly expressed but differentially localized in kidney and intestine. (PubMed id 9819354)^{1, 9} Lueck A....Kwiatkowski D.J. (1998)
The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis. (PubMed id 12438125)^{1, 9} Lejen T....Trifaro J.M. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 85477	HGNC: 21695	AceView: SCIN	Ensembl:ENSG00000006747	euGenes: HUgn85477
ECgene: SCIN	Kegg: 85477	H-InvDB: SCIN

(According to HUGE)
About This Section

HUGE: KIAA1905

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SCIN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SCIN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SCIN gene:
Search GeneIP for patents involving SCIN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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