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Aliases for SCIN Gene

Aliases for SCIN Gene

  • Scinderin 2 3 4 5
  • Adseverin 2
  • KIAA1905 4

External Ids for SCIN Gene

Previous GeneCards Identifiers for SCIN Gene

  • GC07P012254
  • GC07P012354
  • GC07P012383
  • GC07P012576
  • GC07P012488

Summaries for SCIN Gene

Entrez Gene Summary for SCIN Gene

  • SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]

GeneCards Summary for SCIN Gene

SCIN (Scinderin) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Endochondral Ossification. GO annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is VIL1.

UniProtKB/Swiss-Prot for SCIN Gene

  • Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).

Gene Wiki entry for SCIN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCIN Gene

Genomics for SCIN Gene

Regulatory Elements for SCIN Gene

Promoters for SCIN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCIN on UCSC Golden Path with GeneCards custom track

Genomic Location for SCIN Gene

Chromosome:
7
Start:
12,570,349 bp from pter
End:
12,660,179 bp from pter
Size:
89,831 bases
Orientation:
Plus strand

Genomic View for SCIN Gene

Genes around SCIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCIN Gene

Proteins for SCIN Gene

  • Protein details for SCIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6U3-ADSV_HUMAN
    Recommended name:
    Adseverin
    Protein Accession:
    Q9Y6U3
    Secondary Accessions:
    • A8K2U8
    • Q8NBZ6
    • Q8WU97
    • Q96JC7
    • Q96PY2

    Protein attributes for SCIN Gene

    Size:
    715 amino acids
    Molecular mass:
    80489 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB67798.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCIN Gene

    Alternative splice isoforms for SCIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCIN Gene

Proteomics data for SCIN Gene at MOPED

Post-translational modifications for SCIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SCIN Gene

Domains & Families for SCIN Gene

Gene Families for SCIN Gene

Suggested Antigen Peptide Sequences for SCIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6U3

UniProtKB/Swiss-Prot:

ADSV_HUMAN :
  • Belongs to the villin/gelsolin family.
  • Contains 6 gelsolin-like repeats.
Family:
  • Belongs to the villin/gelsolin family.
Similarity:
  • Contains 6 gelsolin-like repeats.
genes like me logo Genes that share domains with SCIN: view

Function for SCIN Gene

Molecular function for SCIN Gene

UniProtKB/Swiss-Prot Function:
Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).

Gene Ontology (GO) - Molecular Function for SCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding ISS --
GO:0051015 actin filament binding ISS --
genes like me logo Genes that share ontologies with SCIN: view
genes like me logo Genes that share phenotypes with SCIN: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCIN Gene

Localization for SCIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCIN Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCIN Gene COMPARTMENTS Subcellular localization image for SCIN gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4
plasma membrane 3
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005903 brush border IEA --
genes like me logo Genes that share ontologies with SCIN: view

Pathways & Interactions for SCIN Gene

genes like me logo Genes that share pathways with SCIN: view

Pathways by source for SCIN Gene

Gene Ontology (GO) - Biological Process for SCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042989 sequestering of actin monomers IMP 19666531
GO:0051014 actin filament severing IMP 11568009
GO:0051127 positive regulation of actin nucleation IMP 19666531
GO:0051693 actin filament capping IMP 19666531
genes like me logo Genes that share ontologies with SCIN: view

No data available for SIGNOR curated interactions for SCIN Gene

Drugs & Compounds for SCIN Gene

(3) Drugs for SCIN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(128) Additional Compounds for SCIN Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with SCIN: view

Transcripts for SCIN Gene

Unigene Clusters for SCIN Gene

Scinderin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCIN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - -
SP6: -
SP7: -
SP8: -

ExUns: 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SCIN Gene

GeneLoc Exon Structure for
SCIN
ECgene alternative splicing isoforms for
SCIN

Expression for SCIN Gene

mRNA expression in normal human tissues for SCIN Gene

mRNA differential expression in normal tissues according to GTEx for SCIN Gene

This gene is overexpressed in Kidney - Cortex (x7.1), Brain - Spinal cord (cervical c-1) (x5.2), Esophagus - Mucosa (x4.3), Small Intestine - Terminal Ileum (x4.2), and Colon - Transverse (x4.1).

Protein differential expression in normal tissues from HIPED for SCIN Gene

This gene is overexpressed in Stomach (26.2) and Lung (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCIN Gene



SOURCE GeneReport for Unigene cluster for SCIN Gene Hs.655515

genes like me logo Genes that share expression patterns with SCIN: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SCIN Gene

Orthologs for SCIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCIN 35
  • 99.16 (n)
  • 99.44 (a)
SCIN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCIN 36
  • 89 (a)
OneToOne
SCIN 35
  • 88.8 (n)
  • 90.34 (a)
dog
(Canis familiaris)
Mammalia SCIN 35
  • 90.19 (n)
  • 92.72 (a)
mouse
(Mus musculus)
Mammalia Scin 16
Scin 36
  • 91 (a)
OneToOne
Scin 35
  • 86.81 (n)
  • 91.47 (a)
oppossum
(Monodelphis domestica)
Mammalia SCIN 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCIN 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scin 35
  • 86.71 (n)
  • 91.61 (a)
chicken
(Gallus gallus)
Aves SCIN 35
  • 76.55 (n)
  • 80.7 (a)
SCIN 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCIN 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495760 35
  • 72.3 (n)
  • 74.23 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6995 35
zebrafish
(Danio rerio)
Actinopterygii scin 36
  • 70 (a)
OneToOne
scin 35
  • 68.12 (n)
  • 71.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6001 36
  • 42 (a)
OneToMany
Species with no ortholog for SCIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCIN Gene

ENSEMBL:
Gene Tree for SCIN (if available)
TreeFam:
Gene Tree for SCIN (if available)

Paralogs for SCIN Gene

Paralogs for SCIN Gene

(6) SIMAP similar genes for SCIN Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SCIN: view

Variants for SCIN Gene

Sequence variations from dbSNP and Humsavar for SCIN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17166250 - 12,636,088(+) CTGCG(C/T)TCCTG nc-transcript-variant, reference, missense
rs1138957 - 12,644,290(+) ACCTT(A/T)AGGAT intron-variant, reference, missense
rs2240572 - 12,570,968(+) CTACC(A/G)CCTGC nc-transcript-variant, reference, missense
rs35083013 - 12,636,052(+) AAGGA(A/C/G)CAAAT nc-transcript-variant, reference, missense
rs35705332 - 12,640,435(+) ATCAA(A/G)GAAAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SCIN Gene

Variant ID Type Subtype PubMed ID
nsv528031 CNV Loss 19592680
nsv470066 CNV Loss 18288195
nsv464379 CNV Loss 19166990
nsv521176 CNV Gain 19592680
nsv527833 CNV Loss 19592680
nsv818483 CNV Gain 17921354
esv2596299 CNV Deletion 19546169
nsv524108 CNV Loss 19592680
dgv406n21 CNV Loss 19592680
nsv520866 CNV Loss 19592680
nsv519573 CNV Loss 19592680
nsv830907 CNV Loss 17160897

Variation tolerance for SCIN Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.30; 96.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCIN Gene

HapMap Linkage Disequilibrium report
SCIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCIN Gene

Disorders for SCIN Gene

Relevant External Links for SCIN

Genetic Association Database (GAD)
SCIN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCIN

No disorders were found for SCIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCIN Gene

Publications for SCIN Gene

  1. The crystal structure of the C-terminus of adseverin reveals the actin-binding interface. (PMID: 19666531) Chumnarnsilpa S. … Robinson R.C. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 23 67
  2. Barrier role of actin filaments in regulated mucin secretion from airway goblet cells. (PMID: 15342343) Ehre C. … Davis C.W. (Am. J. Physiol., Cell Physiol. 2005) 3 23
  3. The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis. (PMID: 12438125) Lejen T. … TrifarA^ J.M. (Ann. N. Y. Acad. Sci. 2002) 3 23
  4. Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis. (PMID: 11568009) Zunino R. … TrifarA^ J.M. (Blood 2001) 3 23
  5. The actin-binding proteins adseverin and gelsolin are both highly expressed but differentially localized in kidney and intestine. (PMID: 9819354) Lueck A. … Kwiatkowski D.J. (J. Cell. Sci. 1998) 3 23

Products for SCIN Gene

Sources for SCIN Gene

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