SCIMP Gene
protein-coding GIFtS: 38
GCID: GC17M005113
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SLP adaptor and CSK interacting membrane protein(Previous name: chromosome 17 open reading frame 87 )
(Previous symbol: C17orf87)
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Aliases
for SCIMP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SLP Adaptor And CSK Interacting Membrane Protein1 2 | | MGC1634261 | | C17orf871 2 3 | | MGC1634281 | | DTFT57831 2 | | Chromosome 17 Open Reading Frame 871 | | UNQ57831 2 | | SLP Adapter And CSK-Interacting Membrane Protein2 | | SLP65/SLP76, Csk-Interacting Membrane Protein2 3 | | Transmembrane Protein C17orf872 | | FLJ325801 | | |
Export aliases for SCIMP gene to outside databases |
Summaries
for SCIMP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SCIMP:
This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in theimmunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transductionand immune synapse formation. Alternatively spliced transcript variants have been found for this gene. (provided byRefSeq, Dec 2012)
UniProtKB/Swiss-Prot: SCIMP_HUMAN, Q6UWF3Function: Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex(MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity uponMHC-II stimulation
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Genomic Views
for SCIMP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SCIMP
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCIMP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCIMP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2SCIMP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M005113: view genomic region
(about GC identifiers)
Start:
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5,112,256 bp from pter |
End:
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5,138,155 bp from pter |
Size:
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25,900 bases |
Orientation:
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minus strand |
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Proteins
for SCIMP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCIMP_HUMAN, Q6UWF3 (See
protein sequence)Recommended Name: SLP adapter and CSK-interacting membrane protein Size: 145 amino acids; 16618 Da
Subunit: Interacts with CD37, CD53 and CD81. Interacts with BLNK and GRB2 isoform 1. Interacts (via prolin-rich region)with LYN (via SH3 domain). Interacts with CSK (via SH2 domain)
Subcellular location: Membrane; Single-pass membrane protein (Potential). Membrane; Lipid-anchor. Note=Together withMHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs). Rapidlytranslocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) andT-cells. Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod. Present at regions of cell-cell contactsbut also at the leading edge of migrating cells
Caution: It is uncertain whether Met-1 or Met-12 is the initiator
Secondary accessions: B4DLK1 Q96MD0Alternative splicing: 2 isoforms: Q6UWF3-1 Q6UWF3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SCIMP: NX_Q6UWF3
Post-translational modifications:
Phosphorylated. Phosphorylation occurs on tyrosine residues by tyrosine-protein kinases LYN and SRC upon MHC-IIstimulation1
Palmitoylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UWF3
SCIMP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001258771.1 NP_996986.1
ENSEMBL proteins: ENSP00000461269 ENSP00000382509 ENSP00000459605 ENSP00000459153
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
SCIMP for ontologies About GeneDecksing
SCIMP Antibody Products:
Assay Products for SCIMP: |
Protein
Domains /
Families
for SCIMP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6UWF3 |
Function
for SCIMP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SCIMP_HUMAN, Q6UWF3Function: Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex(MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity uponMHC-II stimulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCIMP (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCIMP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SCIMP | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCIMP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCIMP |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
SCIMP for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SCIMP:
Animal Models:
Mouse knock-out Scimptm1Lex for SCIMP
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Scimp):
SCIMP for phenotypes About GeneDecksing
|
Pathways & Interactions
for SCIMP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCIMP
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
IDA | -- |
SCIMP for ontologies About GeneDecksing
|
Drugs & Compounds
for SCIMP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SCIMP
Search CenterWatch for drugs/clinical trials and news about SCIMP
|
Transcripts
for SCIMP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCIMP gene (2 alternative transcripts): NM_001271842.1 NM_207103.3 Unigene Cluster for SCIMP: SLP adaptor and CSK interacting membrane protein Hs.462080 [show with all ESTs]Unigene Representative Sequence: NM_2071034 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000574081(uc002gbh.2) ENST00000399600(uc010clb.1) ENST00000571800(uc002gbi.2)
ENST00000574297
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCIMP (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCIMP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SCIMP | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCIMP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCIMP |
Additional cDNA sequence: AK057142.1 AK297035.1 AK310145.1 AY358809.1 BC127925.1 BC130554.1 BC130556.1 BC144395.1 DQ778084.1 5 DOTS entries: DT.86844649 DT.40125945 DT.95158313 DT.120906940 DT.99993393 24/32 AceView cDNA sequences (see all 32): CA394486 AA827110 CR612993 AY358809 CD366373 AI582365 AW575021 AW662810 BX279842 AI823787 T95272 CA748490 BX410087 AK057142 CA306389 AI825110 NM_207103 AW016164 BX411363 AA731090 AW501476 AW401804 BQ054929 AL559654
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SCIMP About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|
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| SP1: | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SCIMP
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Expression
for SCIMP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCIMP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCTGAGTG
About this image
See SCIMP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCIMP
SOURCE GeneReport for Unigene cluster: Hs.462080
UniProtKB/Swiss-Prot: SCIMP_HUMAN, Q6UWF3Tissue specificity: Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-deriveddendritic cells (MDDC) (at protein level). Highly expressed in lymph nodes and spleen. Expressed in antigen-presentingcells. Faintly expressed in the majority of nonimmune system tissues
SABiosciences Custom PCR Arrays for SCIMP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCIMP
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SCIMP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCIMP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCIMP |
Orthologs
for SCIMP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SCIMP gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Scimp1 , 5 |
RIKEN cDNA A430084P05 gene5
SLP adaptor and CSK interacting membrane protein1 |
76.92(n)1
68.46(a)1 |
|
11 (43.21 cM)5
3279571 NM_001045526.21 NP_001038991.11
707909325 |
ENSEMBL Gene Tree for SCIMP (if available)
TreeFam Gene Tree for SCIMP (if available) |
Paralogs
for SCIMP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SCIMP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCIMP (5112256 - 5138155 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCIMP: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCIMP |
|
Disorders
/ Diseases
for SCIMP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCIMP for disorders About GeneDecksing
OMIM gene information: 614406
OMIM disorders: --
1  disease for SCIMP: About MalaCardsfainting
Export disorders for SCIMP gene to outside databases
|
Publications
for SCIMP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCIMP gene integrated from 9 sources:
(articles sorted by number of sources associating them with SCIMP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling. (PubMed id 21930792)1, 2, 3 Draber P....Brdicka T. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SCIMP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCIMP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCIMP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCIMP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SCIMP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SCIMP gene:
Search GeneIP for patents involving SCIMP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCIMP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCIMP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCIMP | | | OriGene Protein Over-expression Lysate for SCIMP | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCIMP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCIMP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SCIMP | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SCIMP | | OriGene Custom Protein Services for SCIMP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCIMP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCIMP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCIMP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCIMP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCIMP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCIMP |
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 | | | SCIMP Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SCIMP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCIMP |
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