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Aliases for SCIMP Gene

Aliases for SCIMP Gene

  • SLP Adaptor And CSK Interacting Membrane Protein 2 3
  • C17orf87 3 4 6
  • SLP65/SLP76, Csk-Interacting Membrane Protein 3 4
  • SLP Adapter And CSK-Interacting Membrane Protein 3
  • Chromosome 17 Open Reading Frame 87 2
  • Csk-Interacting Membrane Protein 2
  • Transmembrane Protein C17orf87 3
  • SLP65/SLP76 2
  • DTFT5783 3
  • UNQ5783 3

External Ids for SCIMP Gene

Previous Symbols for SCIMP Gene

  • C17orf87

Summaries for SCIMP Gene

Entrez Gene Summary for SCIMP Gene

  • This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for SCIMP Gene

SCIMP (SLP Adaptor And CSK Interacting Membrane Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SCIMP Gene

  • Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCIMP Gene

Genomics for SCIMP Gene

Genomic Location for SCIMP Gene

Start:
5,208,920 bp from pter
End:
5,234,879 bp from pter
Size:
25,960 bases
Orientation:
Minus strand

Genomic View for SCIMP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCIMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCIMP Gene

No data available for Regulatory Elements for SCIMP Gene

Proteins for SCIMP Gene

  • Protein details for SCIMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWF3-SCIMP_HUMAN
    Recommended name:
    SLP adapter and CSK-interacting membrane protein
    Protein Accession:
    Q6UWF3
    Secondary Accessions:
    • A6XGL4
    • B4DLK1
    • Q96MD0

    Protein attributes for SCIMP Gene

    Size:
    145 amino acids
    Molecular mass:
    16618 Da
    Quaternary structure:
    • Interacts with CD37, CD53 and CD81. Interacts with BLNK and GRB2 isoform 1. Interacts (via prolin-rich region) with LYN (via SH3 domain). Interacts with CSK (via SH2 domain).

    Alternative splice isoforms for SCIMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCIMP Gene

Proteomics data for SCIMP Gene at MOPED

Post-translational modifications for SCIMP Gene

  • Palmitoylated.
  • Phosphorylated. Phosphorylation occurs on tyrosine residues by tyrosine-protein kinases LYN and SRC upon MHC-II stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCIMP Gene

No data available for DME Specific Peptides for SCIMP Gene

Domains for SCIMP Gene

Protein Domains for SCIMP Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SCIMP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SCIMP Gene

Function for SCIMP Gene

Molecular function for SCIMP Gene

UniProtKB/Swiss-Prot Function: Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation.

Gene Ontology (GO) - Molecular Function for SCIMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21930792
genes like me logo Genes that share ontologies with SCIMP: view
genes like me logo Genes that share phenotypes with SCIMP: view

Animal Models for SCIMP Gene

MGI Knock Outs for SCIMP:

miRNA for SCIMP Gene

miRTarBase miRNAs that target SCIMP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SCIMP Gene

Localization for SCIMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCIMP Gene

Membrane; Single-pass membrane protein. Membrane; Lipid-anchor. Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) and T-cells. Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod. Present at regions of cell-cell contacts but also at the leading edge of migrating cells.

Gene Ontology (GO) - Cellular Components for SCIMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 21930792
GO:0016020 membrane IDA 21930792
GO:0016021 integral component of membrane IEA --
GO:0031256 leading edge membrane IDA 21930792
GO:0031259 uropod membrane IDA 21930792
genes like me logo Genes that share ontologies with SCIMP: view

Pathways for SCIMP Gene

SuperPathways for SCIMP Gene

No Data Available

Interacting Proteins for SCIMP Gene

Gene Ontology (GO) - Biological Process for SCIMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 21930792
genes like me logo Genes that share ontologies with SCIMP: view

No data available for Pathways by source for SCIMP Gene

Transcripts for SCIMP Gene

Unigene Clusters for SCIMP Gene

SLP adaptor and CSK interacting membrane protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCIMP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for SCIMP Gene

GeneLoc Exon Structure for
SCIMP
ECgene alternative splicing isoforms for
SCIMP

Expression for SCIMP Gene

mRNA expression in normal human tissues for SCIMP Gene

mRNA differential expression in normal tissues according to GTEx for SCIMP Gene

This gene is overexpressed in Whole Blood (9.4) and Spleen (8.1).

SOURCE GeneReport for Unigene cluster for SCIMP Gene Hs.462080

mRNA Expression by UniProt/SwissProt for SCIMP Gene

Q6UWF3-SCIMP_HUMAN
Tissue specificity: Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-derived dendritic cells (MDDC) (at protein level). Highly expressed in lymph nodes and spleen. Expressed in antigen-presenting cells. Faintly expressed in the majority of nonimmune system tissues.
genes like me logo Genes that share expressions with SCIMP: view

Orthologs for SCIMP Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCIMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCIMP 36
  • 97.24 (n)
  • 97.24 (a)
SCIMP 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCIMP 36
  • 78.81 (n)
  • 64.29 (a)
SCIMP 37
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCIMP 36
  • 77.24 (n)
  • 73.79 (a)
SCIMP 37
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scimp 36
  • 76.92 (n)
  • 68.46 (a)
Scimp 16
Scimp 37
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCIMP 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scimp 36
  • 76.67 (n)
  • 63.85 (a)
Species with no ortholog for SCIMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCIMP Gene

ENSEMBL:
Gene Tree for SCIMP (if available)
TreeFam:
Gene Tree for SCIMP (if available)

Paralogs for SCIMP Gene

Selected SIMAP similar genes for SCIMP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCIMP: view

No data available for Paralogs for SCIMP Gene

Variants for SCIMP Gene

Sequence variations from dbSNP and Humsavar for SCIMP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8069837 -- 5,236,230(+) agaga(C/T)agggt upstream-variant-2KB
rs8070418 -- 5,236,231(+) gagac(A/G)gggtt upstream-variant-2KB
rs12950359 -- 5,236,790(+) AGCTG(G/T)GACTT upstream-variant-2KB
rs57402520 -- 5,236,512(+) GACCA(A/G)CCTGG upstream-variant-2KB
rs58124010 -- 5,236,513(+) ACCAG(C/T)CTGGC upstream-variant-2KB

Relevant External Links for SCIMP Gene

HapMap Linkage Disequilibrium report
SCIMP

No data available for Structural Variations from Database of Genomic Variants (DGV) for SCIMP Gene

Disorders for SCIMP Gene

No disorders were found for SCIMP Gene.

No data available for UniProtKB/Swiss-Prot for SCIMP Gene

Publications for SCIMP Gene

  1. SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling. (PMID: 21930792) Draber P. … Brdicka T. (Mol. Cell. Biol. 2011) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SCIMP Gene

Sources for SCIMP Gene

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