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Aliases for SCHIP1 Gene

Aliases for SCHIP1 Gene

  • Schwannomin Interacting Protein 1 2 3 5
  • SCHIP-1 3 4
  • Schwannomin Interacting Protein 1 Variant 2 2
  • Schwannomin Interacting Protein 1 Variant 1 2
  • Schwannomin-Interacting Protein 1 2

External Ids for SCHIP1 Gene

Previous GeneCards Identifiers for SCHIP1 Gene

  • GC03P156276
  • GC03P159938
  • GC03P160272
  • GC03P160312
  • GC03P160474
  • GC03P158991
  • GC03P156388

Summaries for SCHIP1 Gene

GeneCards Summary for SCHIP1 Gene

SCHIP1 (Schwannomin Interacting Protein 1) is a Protein Coding gene. Diseases associated with SCHIP1 include Renal Cell Carcinoma, Papillary. GO annotations related to this gene include identical protein binding. An important paralog of this gene is IQCJ-SCHIP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCHIP1 Gene

Genomics for SCHIP1 Gene

Regulatory Elements for SCHIP1 Gene

Enhancers for SCHIP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCHIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCHIP1 Gene

159,273,247 bp from pter
159,897,366 bp from pter
624,120 bases
Plus strand

Genomic View for SCHIP1 Gene

Genes around SCHIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCHIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCHIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCHIP1 Gene

Proteins for SCHIP1 Gene

  • Protein details for SCHIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Schwannomin-interacting protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KRM0
    • O75543
    • Q00P30
    • Q00P31
    • Q7Z3Y3
    • Q8IY83
    • Q9P0W3
    • Q9P0W4

    Protein attributes for SCHIP1 Gene

    487 amino acids
    Molecular mass:
    53480 Da
    Quaternary structure:
    • Isoform 5 interacts (via C-terminal IQ motif) with calmodulin in the absence of Ca(2+) (By similarity). Isoform 5 interacts (via C-terminus) with ANK3 (via N-terminal ANK repeats); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). Self-associates through its coiled coil domain. Interacts with NF2 isoform 4, but not NF2 isoform 1. Interacts with NF2 variant PHE-119 DEL.

    Alternative splice isoforms for SCHIP1 Gene

neXtProt entry for SCHIP1 Gene

Proteomics data for SCHIP1 Gene at MOPED

Post-translational modifications for SCHIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCHIP1 Gene

No data available for DME Specific Peptides for SCHIP1 Gene

Domains & Families for SCHIP1 Gene

Protein Domains for SCHIP1 Gene


Suggested Antigen Peptide Sequences for SCHIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SCHIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SCHIP1 Gene

Function for SCHIP1 Gene

genes like me logo Genes that share phenotypes with SCHIP1: view

Animal Model Products

miRNA for SCHIP1 Gene

miRTarBase miRNAs that target SCHIP1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCHIP1 Gene

Localization for SCHIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCHIP1 Gene

Cytoplasm. Note=Partially colocalizes with NF2 beneath the cytoplasmic membrane.

Subcellular locations from

Jensen Localization Image for SCHIP1 Gene COMPARTMENTS Subcellular localization image for SCHIP1 gene
Compartment Confidence
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SCHIP1 Gene

Pathways & Interactions for SCHIP1 Gene

SuperPathways for SCHIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCHIP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SCHIP1 Gene

Drugs & Compounds for SCHIP1 Gene

No Compound Related Data Available

Transcripts for SCHIP1 Gene

Unigene Clusters for SCHIP1 Gene

Schwannomin interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCHIP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -

Relevant External Links for SCHIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCHIP1 Gene

mRNA expression in normal human tissues for SCHIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCHIP1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.2) and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for SCHIP1 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCHIP1 Gene

SOURCE GeneReport for Unigene cluster for SCHIP1 Gene Hs.134665

mRNA Expression by UniProt/SwissProt for SCHIP1 Gene

Tissue specificity: Isoform 5 and isoform 6 are highly expressed in the brain. Both isoforms derive from naturally occurring readthrough transcripts which produce IQCJ-SCHIP1 fusion proteins.
genes like me logo Genes that share expression patterns with SCHIP1: view

Protein tissue co-expression partners for SCHIP1 Gene

Primer Products

Orthologs for SCHIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCHIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Schip1 35
  • 88.79 (n)
  • 91.06 (a)
Schip1 16
(Bos Taurus)
Mammalia SCHIP1 36
  • 89 (a)
(Monodelphis domestica)
Mammalia SCHIP1 36
  • 97 (a)
(Pan troglodytes)
Mammalia SCHIP1 36
  • 100 (a)
(Gallus gallus)
Aves SCHIP1 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia schip1 35
  • 72.11 (n)
  • 77.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13987 35
(Danio rerio)
Actinopterygii Dr.14061 35
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5375 36
  • 9 (a)
Species with no ortholog for SCHIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCHIP1 Gene

Gene Tree for SCHIP1 (if available)
Gene Tree for SCHIP1 (if available)

Paralogs for SCHIP1 Gene

Paralogs for SCHIP1 Gene

(1) SIMAP similar genes for SCHIP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCHIP1: view

Variants for SCHIP1 Gene

Sequence variations from dbSNP and Humsavar for SCHIP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_032534 -
VAR_051332 -

Structural Variations from Database of Genomic Variants (DGV) for SCHIP1 Gene

Variant ID Type Subtype PubMed ID
nsv470971 CNV Gain 18288195
esv2659056 CNV Deletion 23128226
esv259484 OTHER Complex 20981092
esv259680 OTHER Complex 20981092
esv5498 CNV Gain 19470904
nsv877695 CNV Gain 21882294
nsv4082 CNV Insertion 18451855
esv2678454 CNV Deletion 23128226
dgv5281n71 CNV Gain 21882294
esv2644833 CNV Deletion 19546169
nsv519199 CNV Loss 19592680
nsv511197 CNV Loss 21212237
nsv513091 CNV Loss 21212237
nsv820265 CNV Gain 19587683
dgv834n67 CNV Loss 20364138
nsv821438 CNV Deletion 20802225
esv4370 CNV Deletion 18987735
esv2726105 CNV Deletion 23290073
esv22799 CNV Gain 19812545
esv992343 CNV Deletion 20482838
esv2657975 CNV Deletion 23128226
nsv522248 CNV Loss 19592680
esv2138340 CNV Deletion 18987734
nsv4083 CNV Insertion 18451855
esv2560522 CNV Deletion 19546169
esv1917039 CNV Deletion 18987734
esv2664613 CNV Deletion 23128226
esv993836 CNV Deletion 20482838
esv2726107 CNV Deletion 23290073
esv1616680 CNV Deletion 17803354
esv2669077 CNV Deletion 23128226
esv24925 CNV Loss 19812545
nsv818181 CNV Loss 17921354
esv2726108 CNV Deletion 23290073
nsv4084 CNV Loss 18451855
esv2674821 CNV Deletion 23128226
nsv4085 CNV Insertion 18451855
nsv877698 CNV Gain 21882294
esv23556 CNV Loss 19812545
esv259860 OTHER Complex 20981092
nsv829769 CNV Gain 17160897
nsv4086 CNV Loss 18451855
nsv4087 CNV Insertion 18451855

Variation tolerance for SCHIP1 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCHIP1 Gene

Disorders for SCHIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCHIP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary
  • renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SCHIP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCHIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCHIP1 Gene

Publications for SCHIP1 Gene

  1. Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins. (PMID: 10669747) Goutebroze L. … Thomas G. (Mol. Cell. Biol. 2000) 2 3 4 23 67
  2. IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein. (PMID: 17045569) Kwasnicka-Crawford D.A. … Scherer S.W. (Biochem. Biophys. Res. Commun. 2006) 2 3 23
  3. Assignment of the schwannomin-interacting protein 1 (SCHIP1) gene to human chromosome band 3q25 by in situ hybridization and with somatic cell hybrids. (PMID: 11701967) Goutebroze L. … Thomas G. (Cytogenet. Cell Genet. 2001) 3 23
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  5. Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin. (PMID: 25807495) Perisic L. … Patrakka J. (PLoS ONE 2015) 3

Products for SCHIP1 Gene

Sources for SCHIP1 Gene