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Aliases for SCGN Gene

Aliases for SCGN Gene

  • Secretagogin, EF-Hand Calcium Binding Protein 2 3 5
  • SECRET 3 4
  • Calbindin-Like 2
  • Secretagogin 3
  • DJ501N12.8 3
  • Setagin 3
  • CALBL 3
  • SEGN 3

External Ids for SCGN Gene

Previous GeneCards Identifiers for SCGN Gene

  • GC06P025709
  • GC06P025760

Summaries for SCGN Gene

Entrez Gene Summary for SCGN Gene

  • The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCGN Gene

SCGN (Secretagogin, EF-Hand Calcium Binding Protein) is a Protein Coding gene. Among its related pathways are Ca, cAMP and Lipid Signaling and Neuroscience. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CALB2.

Gene Wiki entry for SCGN Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGN Gene

Genomics for SCGN Gene

Regulatory Elements for SCGN Gene

Enhancers for SCGN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F025660 1.1 Ensembl ENCODE 16.6 +8.4 8377 1.1 ZNF48 GLIS2 FOS MIER2 REST KAT8 PPARGC1A NFIL3 SMARCA4 RFX3 SCGN LOC101928663 RPL21P68 GC06P025671
GH06F025652 0.6 ENCODE 15.9 +0.2 187 0.2 MLX ZFP64 ARID4B ZNF48 SLC30A9 ZNF766 ELK1 ZNF143 ZNF263 MXD4 SCGN GC06P025671
GH06F025630 0.3 FANTOM5 14.9 -22.1 -22084 0.2 CTBP1 RFX1 CEBPG SCGN LOC101928663 RPL21P68 CMAHP LOC100533655 SLC17A4 GC06M025617
GH06F025641 0.2 ENCODE 14.1 -10.0 -9963 1.3 ELF3 ZNF48 RARA SLC30A9 CREM MIXL1 THAP11 MIER2 NFIL3 MIER3 SCGN SLC17A4 CARMIL1 ENSG00000272462 GC06M025617
GH06F025635 0.5 ENCODE 12 -15.9 -15924 1.9 ATF1 MLX ZFP64 ARID4B DMAP1 SLC30A9 ZHX2 MIER2 PPARG ZNF264 ABT1 SCGN HMGN4 NUP50P2 RPL21P68 LOC101928663 CARMIL1 HCG11 GC06M025617
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SCGN on UCSC Golden Path with GeneCards custom track

Promoters for SCGN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001879377 100 600 MLX ZFP64 ARID4B ZNF48 SLC30A9 ZNF766 ZNF143 ZNF263 MXD4 NCOA1

Genomic Location for SCGN Gene

Chromosome:
6
Start:
25,652,201 bp from pter
End:
25,701,783 bp from pter
Size:
49,583 bases
Orientation:
Plus strand

Genomic View for SCGN Gene

Genes around SCGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGN Gene

Proteins for SCGN Gene

  • Protein details for SCGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76038-SEGN_HUMAN
    Recommended name:
    Secretagogin
    Protein Accession:
    O76038
    Secondary Accessions:
    • A8K0B2
    • Q5VV44
    • Q96QV7
    • Q9UJF6

    Protein attributes for SCGN Gene

    Size:
    276 amino acids
    Molecular mass:
    32040 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCGN Gene

Post-translational modifications for SCGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGN Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SCGN (SCGN)
  • Santa Cruz Biotechnology (SCBT) Antibodies for SCGN

No data available for DME Specific Peptides for SCGN Gene

Domains & Families for SCGN Gene

Gene Families for SCGN Gene

Protein Domains for SCGN Gene

Suggested Antigen Peptide Sequences for SCGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76038

UniProtKB/Swiss-Prot:

SEGN_HUMAN :
  • Contains 6 EF-hand domains.
Domain:
  • Contains 6 EF-hand domains.
genes like me logo Genes that share domains with SCGN: view

Function for SCGN Gene

Gene Ontology (GO) - Molecular Function for SCGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 10811645
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SCGN: view
genes like me logo Genes that share phenotypes with SCGN: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGN Gene

Localization for SCGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGN Gene

Cytoplasm. Secreted. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity). Detectable in human serum after ischemic neuronal damage. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGN Gene COMPARTMENTS Subcellular localization image for SCGN gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 3
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SCGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm NAS 10811645
GO:0005829 cytosol IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SCGN: view

Pathways & Interactions for SCGN Gene

genes like me logo Genes that share pathways with SCGN: view

Pathways by source for SCGN Gene

2 Cell Signaling Technology pathways for SCGN Gene

Gene Ontology (GO) - Biological Process for SCGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0051480 regulation of cytosolic calcium ion concentration IBA --
genes like me logo Genes that share ontologies with SCGN: view

No data available for SIGNOR curated interactions for SCGN Gene

Drugs & Compounds for SCGN Gene

(1) Drugs for SCGN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SCGN: view

Transcripts for SCGN Gene

Unigene Clusters for SCGN Gene

Secretagogin, EF-hand calcium binding protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGN Gene

No ASD Table

Relevant External Links for SCGN Gene

GeneLoc Exon Structure for
SCGN
ECgene alternative splicing isoforms for
SCGN

Expression for SCGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCGN Gene

This gene is overexpressed in Brain - Hypothalamus (x12.1), Pituitary (x7.5), Pancreas (x7.1), Brain - Cerebellum (x5.7), and Brain - Cerebellar Hemisphere (x5.0).

Protein differential expression in normal tissues from HIPED for SCGN Gene

This gene is overexpressed in Islet of Langerhans (37.1) and Pancreas (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCGN Gene



NURSA nuclear receptor signaling pathways regulating expression of SCGN Gene:

SCGN

SOURCE GeneReport for Unigene cluster for SCGN Gene:

Hs.116428

mRNA Expression by UniProt/SwissProt for SCGN Gene:

O76038-SEGN_HUMAN
Tissue specificity: Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons.
genes like me logo Genes that share expression patterns with SCGN: view

Primer Products

No data available for Protein tissue co-expression partners for SCGN Gene

Orthologs for SCGN Gene

This gene was present in the common ancestor of animals.

Orthologs for SCGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGN 34 35
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia SCGN 34 35
  • 90.46 (n)
dog
(Canis familiaris)
Mammalia SCGN 34 35
  • 88.16 (n)
rat
(Rattus norvegicus)
Mammalia Scgn 34
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Scgn 34 16 35
  • 82.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SCGN 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCGN 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCGN 34 35
  • 75.56 (n)
lizard
(Anolis carolinensis)
Reptilia SCGN 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scgn 34
  • 72.96 (n)
zebrafish
(Danio rerio)
Actinopterygii scgn 34 35
  • 70.96 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4518 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012179 34
  • 54.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cbp53E 36 34 35
  • 53.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13086 34
Species where no ortholog for SCGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCGN Gene

ENSEMBL:
Gene Tree for SCGN (if available)
TreeFam:
Gene Tree for SCGN (if available)

Paralogs for SCGN Gene

Paralogs for SCGN Gene

(2) SIMAP similar genes for SCGN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCGN: view

Variants for SCGN Gene

Sequence variations from dbSNP and Humsavar for SCGN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1003688 -- 25,658,944(+) ATCCT(A/G)GAAGT intron-variant
rs1003967 -- 25,658,679(+) ATTTA(C/T)TTCAA intron-variant
rs10105 -- 25,701,675(+) TTCTT(A/G)TGGGC utr-variant-3-prime
rs1040419 -- 25,652,862(+) TTTAC(G/T)CAGTG intron-variant
rs10456325 -- 25,653,208(+) GTGTT(G/T)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCGN Gene

Variant ID Type Subtype PubMed ID
esv3608389 CNV gain 21293372

Variation tolerance for SCGN Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGN Gene

Disorders for SCGN Gene

Relevant External Links for SCGN

Genetic Association Database (GAD)
SCGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCGN

No disorders were found for SCGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCGN Gene

Publications for SCGN Gene

  1. Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein. (PMID: 10811645) Wagner L. … Pasternack M.S. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein. (PMID: 11709487) Gartner W. … Wagner L. (Cereb. Cortex 2001) 3 4 22 64
  3. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. (PMID: 19503597) Kolz M. … Gieger C. (PLoS Genet. 2009) 3 46 64
  4. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PMID: 19084217) Benyamin B. … Visscher P.M. (Am. J. Hum. Genet. 2009) 3 46 64
  5. Identification and characterization of secretagogin promoter activity. (PMID: 17083620) Skovhus K.V. … Pociot F. (Scand. J. Immunol. 2006) 3 22 64

Products for SCGN Gene

Sources for SCGN Gene

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