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Aliases for SCGN Gene

Aliases for SCGN Gene

  • Secretagogin, EF-Hand Calcium Binding Protein 2 3
  • SECRET 3 4
  • Calbindin-Like 2
  • Secretagogin 3
  • DJ501N12.8 3
  • Setagin 3
  • CALBL 3
  • SEGN 3

External Ids for SCGN Gene

Previous GeneCards Identifiers for SCGN Gene

  • GC06P025709
  • GC06P025760

Summaries for SCGN Gene

Entrez Gene Summary for SCGN Gene

  • The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCGN Gene

SCGN (Secretagogin, EF-Hand Calcium Binding Protein) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CALB2.

Gene Wiki entry for SCGN Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGN Gene

Genomics for SCGN Gene

Regulatory Elements for SCGN Gene

Genomic Location for SCGN Gene

Start:
25,652,201 bp from pter
End:
25,701,783 bp from pter
Size:
49,583 bases
Orientation:
Plus strand

Genomic View for SCGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGN Gene

Proteins for SCGN Gene

  • Protein details for SCGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76038-SEGN_HUMAN
    Recommended name:
    Secretagogin
    Protein Accession:
    O76038
    Secondary Accessions:
    • A8K0B2
    • Q5VV44
    • Q96QV7
    • Q9UJF6

    Protein attributes for SCGN Gene

    Size:
    276 amino acids
    Molecular mass:
    32040 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCGN Gene

Proteomics data for SCGN Gene at MOPED

Post-translational modifications for SCGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SCGN (SCGN)

No data available for DME Specific Peptides for SCGN Gene

Domains for SCGN Gene

Gene Families for SCGN Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for SCGN Gene

Suggested Antigen Peptide Sequences for SCGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76038

UniProtKB/Swiss-Prot:

SEGN_HUMAN :
  • O76038
Domain:
  • Contains 6 EF-hand domains.
genes like me logo Genes that share domains with SCGN: view

Function for SCGN Gene

Gene Ontology (GO) - Molecular Function for SCGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 10811645
genes like me logo Genes that share ontologies with SCGN: view

Phenotypes for SCGN Gene

GenomeRNAi human phenotypes for SCGN:
genes like me logo Genes that share phenotypes with SCGN: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCGN

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SCGN Gene

Localization for SCGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGN Gene

Cytoplasm. Secreted. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity). Detectable in human serum after ischemic neuronal damage. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGN Gene COMPARTMENTS Subcellular localization image for SCGN gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SCGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm NAS 10811645
GO:0016020 membrane --
GO:0030658 transport vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with SCGN: view

Pathways for SCGN Gene

SuperPathways for SCGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SCGN: view

No data available for Pathways by source for SCGN Gene

Compounds for SCGN Gene

(1) Novoseek inferred chemical compound relationships for SCGN Gene

Compound -log(P) Hits PubMed IDs
calcium 22.8 11
genes like me logo Genes that share compounds with SCGN: view

Transcripts for SCGN Gene

mRNA/cDNA for SCGN Gene

Unigene Clusters for SCGN Gene

Secretagogin, EF-hand calcium binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCGN

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SCGN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGN Gene

No ASD Table

Relevant External Links for SCGN Gene

GeneLoc Exon Structure for
SCGN
ECgene alternative splicing isoforms for
SCGN

Expression for SCGN Gene

mRNA expression in normal human tissues for SCGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCGN Gene

This gene is overexpressed in Brain - Hypothalamus (12.1), Pituitary (7.5), Pancreas (7.1), Brain - Cerebellum (5.7), and Brain - Cerebellar Hemisphere (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCGN Gene

SOURCE GeneReport for Unigene cluster for SCGN Gene Hs.116428

mRNA Expression by UniProt/SwissProt for SCGN Gene

O76038-SEGN_HUMAN
Tissue specificity: Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons.
genes like me logo Genes that share expressions with SCGN: view

In Situ Assay Products

Orthologs for SCGN Gene

This gene was present in the common ancestor of animals.

Orthologs for SCGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGN 35
  • 99.52 (n)
  • 99.28 (a)
SCGN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCGN 35
  • 90.46 (n)
  • 89.49 (a)
SCGN 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCGN 35
  • 88.16 (n)
  • 85.51 (a)
SCGN 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scgn 35
  • 82.97 (n)
  • 84.78 (a)
Scgn 16
Scgn 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCGN 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCGN 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scgn 35
  • 83.33 (n)
  • 83.33 (a)
chicken
(Gallus gallus)
Aves SCGN 35
  • 75.56 (n)
  • 76.32 (a)
SCGN 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCGN 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scgn 35
  • 72.96 (n)
  • 75.47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4518 35
zebrafish
(Danio rerio)
Actinopterygii scgn 35
  • 70.96 (n)
  • 74.26 (a)
scgn 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012179 35
  • 54.41 (n)
  • 49.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cbp53E 35
  • 53.04 (n)
  • 47.21 (a)
Cbp53E 36
  • 38 (a)
OneToMany
Cbp53E 37
  • 45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13086 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for SCGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCGN Gene

ENSEMBL:
Gene Tree for SCGN (if available)
TreeFam:
Gene Tree for SCGN (if available)

Paralogs for SCGN Gene

Paralogs for SCGN Gene

Selected SIMAP similar genes for SCGN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCGN: view

Variants for SCGN Gene

Sequence variations from dbSNP and Humsavar for SCGN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs10105 -- 25,701,675(+) TTCTT(A/G)TGGGC utr-variant-3-prime
rs11794 -- 25,701,490(+) CCACC(A/G)GCGTG utr-variant-3-prime
rs760698 -- 25,685,661(+) ttata(A/G)ttata intron-variant
rs932317 -- 25,675,452(+) tttca(C/T)gccac intron-variant
rs932319 -- 25,675,886(+) accac(C/T)cttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCGN Gene

Variant ID Type Subtype PubMed ID
nsv883488 CNV Gain 21882294

Relevant External Links for SCGN Gene

HapMap Linkage Disequilibrium report
SCGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGN Gene

Disorders for SCGN Gene

(7) Novoseek inferred disease relationships for SCGN Gene

Disease -log(P) Hits PubMed IDs
pituitary adenoma 57.5 7
neuroendocrine tumors 56.8 5
insulinoma 56.4 2
carcinoid 47.2 6
colorectal cancer 30.3 4

Relevant External Links for SCGN

Genetic Association Database (GAD)
SCGN
genes like me logo Genes that share disorders with SCGN: view

No data available for UniProtKB/Swiss-Prot for SCGN Gene

Publications for SCGN Gene

  1. Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein. (PMID: 10811645) Wagner L. … Pasternack M.S. (J. Biol. Chem. 2000) 2 3 4 23
  2. Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein. (PMID: 11709487) Gartner W. … Wagner L. (Cereb. Cortex 2001) 3 4 23
  3. Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas. (PMID: 15237930) Zhan X. … Desiderio D.M. (Pituitary 2003) 3 23
  4. Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene. (PMID: 15766553) Zierhut B. … Wagner L. (Biochem. Biophys. Res. Commun. 2005) 3 23
  5. Identification and characterization of secretagogin promoter activity. (PMID: 17083620) Skovhus K.V. … Pociot F. (Scand. J. Immunol. 2006) 3 23

Products for SCGN Gene

Sources for SCGN Gene

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