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Aliases for SCGB3A2 Gene

Aliases for SCGB3A2 Gene

  • Secretoglobin, Family 3A, Member 2 2 3
  • Uteroglobin-Related Protein 1 2 3 4
  • Pneumo Secretory Protein 1 2 3 4
  • UGRP1 3 4 6
  • PnSP-1 3 4
  • PNSP1 3 4
  • Secretoglobin Family 3A Member 2 3
  • Uteroglobin Related Protein 1 2
  • LU103 3

External Ids for SCGB3A2 Gene

Previous GeneCards Identifiers for SCGB3A2 Gene

  • GC05P147290
  • GC05P147840
  • GC05P147286
  • GC05P147238
  • GC05P142405
  • GC05P147250

Summaries for SCGB3A2 Gene

Entrez Gene Summary for SCGB3A2 Gene

  • The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010]

GeneCards Summary for SCGB3A2 Gene

SCGB3A2 (Secretoglobin, Family 3A, Member 2) is a Protein Coding gene. Diseases associated with SCGB3A2 include asthma and interstitial lung disease. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Binding and Uptake of Ligands by Scavenger Receptors. An important paralog of this gene is SCGB3A1.

Gene Wiki entry for SCGB3A2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB3A2 Gene

Genomics for SCGB3A2 Gene

Regulatory Elements for SCGB3A2 Gene

Genomic Location for SCGB3A2 Gene

Start:
147,870,682 bp from pter
End:
147,882,193 bp from pter
Size:
11,512 bases
Orientation:
Plus strand

Genomic View for SCGB3A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCGB3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB3A2 Gene

Proteins for SCGB3A2 Gene

  • Protein details for SCGB3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PL1-SG3A2_HUMAN
    Recommended name:
    Secretoglobin family 3A member 2
    Protein Accession:
    Q96PL1
    Secondary Accessions:

    Protein attributes for SCGB3A2 Gene

    Size:
    93 amino acids
    Molecular mass:
    10161 Da
    Quaternary structure:
    • Homodimer

neXtProt entry for SCGB3A2 Gene

Proteomics data for SCGB3A2 Gene at MOPED

Post-translational modifications for SCGB3A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB3A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB3A2 Gene

Domains for SCGB3A2 Gene

Gene Families for SCGB3A2 Gene

HGNC:
  • SCGB :Secretoglobins

Protein Domains for SCGB3A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB3A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PL1

UniProtKB/Swiss-Prot:

SG3A2_HUMAN :
  • Q96PL1
Family:
  • Belongs to the secretoglobin family. UGRP subfamily.
genes like me logo Genes that share domains with SCGB3A2: view

Function for SCGB3A2 Gene

Gene Ontology (GO) - Molecular Function for SCGB3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SCGB3A2: view

Phenotypes for SCGB3A2 Gene

GenomeRNAi human phenotypes for SCGB3A2:
genes like me logo Genes that share phenotypes with SCGB3A2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCGB3A2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SCGB3A2 Gene

Localization for SCGB3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB3A2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB3A2 Gene COMPARTMENTS Subcellular localization image for SCGB3A2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0071682 endocytic vesicle lumen TAS --
genes like me logo Genes that share ontologies with SCGB3A2: view

Pathways for SCGB3A2 Gene

genes like me logo Genes that share pathways with SCGB3A2: view

Pathways by source for SCGB3A2 Gene

Interacting Proteins for SCGB3A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296694%0d%0a9606.ENSP00000318916%0d%0a
Selected Interacting proteins: ENSP00000296694 Q96PL1-SG3A2_HUMAN for SCGB3A2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SCGB3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with SCGB3A2: view

Transcripts for SCGB3A2 Gene

mRNA/cDNA for SCGB3A2 Gene

Unigene Clusters for SCGB3A2 Gene

Secretoglobin, family 3A, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCGB3A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB3A2 Gene

No ASD Table

Relevant External Links for SCGB3A2 Gene

GeneLoc Exon Structure for
SCGB3A2
ECgene alternative splicing isoforms for
SCGB3A2

Expression for SCGB3A2 Gene

mRNA expression in normal human tissues for SCGB3A2 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB3A2 Gene

This gene is overexpressed in Lung (50.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCGB3A2 Gene

SOURCE GeneReport for Unigene cluster for SCGB3A2 Gene Hs.483765

mRNA Expression by UniProt/SwissProt for SCGB3A2 Gene

Q96PL1-SG3A2_HUMAN
Tissue specificity: Highly expressed in lung
genes like me logo Genes that share expressions with SCGB3A2: view

In Situ Assay Products

Orthologs for SCGB3A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB3A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB3A2 35
  • 99.64 (n)
  • 100 (a)
SCGB3A2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCGB3A2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCGB3A2 35
  • 84.88 (n)
  • 81.18 (a)
SCGB3A2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scgb3a2 35
  • 79.76 (n)
  • 79.76 (a)
Scgb3a2 16
Scgb3a2 36
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCGB3A2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Scgb3a2 35
  • 82.08 (n)
  • 84.95 (a)
Species with no ortholog for SCGB3A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB3A2 Gene

ENSEMBL:
Gene Tree for SCGB3A2 (if available)
TreeFam:
Gene Tree for SCGB3A2 (if available)

Paralogs for SCGB3A2 Gene

Paralogs for SCGB3A2 Gene

Selected SIMAP similar genes for SCGB3A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCGB3A2: view

Variants for SCGB3A2 Gene

Sequence variations from dbSNP and Humsavar for SCGB3A2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1368408 -- 147,878,599(+) TGTTT(A/G)GTGAG upstream-variant-2KB
rs2116805 -- 147,879,842(+) CTACA(A/C)TGGCA intron-variant
rs2116806 -- 147,880,037(+) AAATT(A/T)AAAAA intron-variant
rs2163787 -- 147,880,153(+) CGTGT(A/G)TGCTC intron-variant
rs2278376 -- 147,878,932(+) GTAAG(A/C)CTTGC intron-variant

Relevant External Links for SCGB3A2 Gene

HapMap Linkage Disequilibrium report
SCGB3A2
Human Gene Mutation Database (HGMD)
SCGB3A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB3A2 Gene

Disorders for SCGB3A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SCGB3A2 Gene including...

Search for SCGB3A2 Gene in MalaCards »

(1) OMIM Diseases for SCGB3A2 Gene (606531)

(1) University of Copenhagen DISEASES for SCGB3A2 Gene

(4) Novoseek inferred disease relationships for SCGB3A2 Gene

Disease -log(P) Hits PubMed IDs
asthma allergic 67.7 7
asthma 52.8 16
genetic susceptibility 49.8 2
inflammation 0 2

Relevant External Links for SCGB3A2

Genetic Association Database (GAD)
SCGB3A2
Human Genome Epidemiology (HuGE) Navigator
SCGB3A2
genes like me logo Genes that share disorders with SCGB3A2: view

No data available for UniProtKB/Swiss-Prot for SCGB3A2 Gene

Publications for SCGB3A2 Gene

  1. UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. (PMID: 11682631) Niimi T. … Kimura S. (Mol. Endocrinol. 2001) 2 3 4 23
  2. A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. (PMID: 11813133) Niimi T. … Kimura S. (Am. J. Hum. Genet. 2002) 3 23 48
  3. Uteroglobin-related protein 1(UGRP1) gene polymorphisms and atopic asthma in the Indian population. (PMID: 15591807) Batra J. … Ghosh B. (Int. Arch. Allergy Immunol. 2005) 3 23 48
  4. Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma. (PMID: 18089940) Inoue K. … Munakata M. (Allergol Int 2008) 3 23 48
  5. Uteroglobin-related protein 1 gene -112G/a polymorphism and atopic asthma in Sicilian children. (PMID: 18201431) Rigoli L. … Salpietro C.D. (Allergy Asthma Proc 2007) 3 23

Products for SCGB3A2 Gene

Sources for SCGB3A2 Gene

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