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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCGB3A2 Gene

protein-coding   GIFtS: 54
GCID: GC05P147238

Secretoglobin, Family 3A, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Secretoglobin, Family 3A, Member 21 2     Uteroglobin Related Protein 11
Pneumo Secretory Protein 11 2 3     LU1032
Uteroglobin-Related Protein 11 2 3     pnSP-12
UGRP12 3 5     Secretoglobin Family 3A Member 22
PNSP12 3     PnSP-13

External Ids:    HGNC: 183911   Entrez Gene: 1171562   Ensembl: ENSG000001642657   OMIM: 6065315   UniProtKB: Q96PL13   

Export aliases for SCGB3A2 gene to outside databases

Previous GC identifers: GC05P147290 GC05P147840 GC05P147286 GC05P142405


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCGB3A2 Gene:
The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid
transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to
asthma.(provided by RefSeq, Mar 2010)

GeneCards Summary for SCGB3A2 Gene: 
SCGB3A2 (secretoglobin, family 3A, member 2) is a protein-coding gene. Diseases associated with SCGB3A2 include interstitial lung disease, and asthma, and among its related super-pathways are Scavenging of Heme from Plasma. An important paralog of this gene is SCGB3A1.

Gene Wiki entry for SCGB3A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCGB3A2 gene promoter:
         Pax-3   POU2F1   Nkx2-2   POU2F1a   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCGB3A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCGB3A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCGB3A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

SCGB3A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCGB3A2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P147238:  view genomic region     (about GC identifiers)

Start:
147,250,245 bp from pter      End:
147,261,756 bp from pter
Size:
11,512 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SG3A2_HUMAN, Q96PL1 (See protein sequence)
Recommended Name: Secretoglobin family 3A member 2 precursor  
Size: 93 amino acids; 10161 Da
Subunit: Homodimer
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for SCGB3A2: NX_Q96PL1

Explore proteomics data for SCGB3A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PL1

  • SCGB3A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCGB3A2 Protein Expression
    REFSEQ proteins: NP_473364.1  
    ENSEMBL proteins: 
     ENSP00000423930   ENSP00000296694  
    Reactome Protein details: Q96PL1
    Human Recombinant Protein Products for SCGB3A2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCGB3A2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0071682endocytic vesicle lumen TAS--

    SCGB3A2 for ontologies           About GeneDecksing



    SCGB3A2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SCGB: Secretoglobins

    1 InterPro protein domain:
     IPR006038 Uteroglobin-like_superfam

    Graphical View of Domain Structure for InterPro Entry Q96PL1

    ProtoNet protein and cluster: Q96PL1

    UniProtKB/Swiss-Prot: SG3A2_HUMAN, Q96PL1
    Similarity: Belongs to the secretoglobin family. UGRP subfamily


    SCGB3A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SCGB3A2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SCGB3A2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCGB3A2 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SCGB3A2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.63
    2Scavenging by Class A Receptors
    Scavenging by Class A Receptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for SCGB3A2
        Scavenging by Class A Receptors
    Binding and Uptake of Ligands by Scavenger Receptors



    SCGB3A2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCGB3A2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SCGB3A2 (Q96PL13 ENSP000002966944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARCOQ9UEW33, ENSP000003189164I2D: score=2 STRING: ENSP00000318916
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCGB3A2 (SG3A2)

    Search CenterWatch for drugs/clinical trials and news about SCGB3A2 / SG3A2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCGB3A2 gene: 
    NM_054023.4  

    Unigene Cluster for SCGB3A2:

    Secretoglobin, family 3A, member 2
    Hs.483765  [show with all ESTs]
    Unigene Representative Sequence: BI518636
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504320 ENST00000507160 ENST00000514688 ENST00000296694(uc003lot.2)

    miRNA
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    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCGB3A2
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    Additional mRNA sequence: 

    AF313455.1 AF439545.1 AY358979.1 BC024232.1 

    3 DOTS entries:

    DT.213241  DT.100746709  DT.95158474 

    24/69 AceView cDNA sequences (see all 69):

    BE328852 AW449467 AF313455 AA988921 BE222065 D31079 BF111035 AI354759 
    AI355612 AI693419 BE218717 AI265819 BC024232 AI263451 AI193016 AA988559 
    AA358271 AI298558 BE552278 AI695085 AI355302 BE348591 BI770763 AI668642 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCGB3A2 expression in normal human tissues (normalized intensities)      SCGB3A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCTGGTAA
    SCGB3A2 Expression
    About this image


    SCGB3A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 8 entries
             Line H9 (WA09)
             ESI-017   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Proximal Lung Epithelial Cells Stem Bronchi
             Trachea
             Lung Epithelial Progenitors ( Efficient derivation of purified lung and thyroid progenitor...
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   
             bronchoalveolar lavage cells   
     
     Endothelium (Cardiovascular System)
             Endothelial progenitor cells ( Derivation and purification of endothelial precursor...
     
     Epithelium (Uncategorized)
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   

    See SCGB3A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCGB3A2

    SOURCE GeneReport for Unigene cluster: Hs.483765

    UniProtKB/Swiss-Prot: SG3A2_HUMAN, Q96PL1
    Tissue specificity: Highly expressed in lung

        SABiosciences Custom PCR Arrays for SCGB3A2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SCGB3A2 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scgb3a21 , 5 secretoglobin, family 3A, member 21, 5 79.76(n)1
    79.76(a)1
      18 (23.49 cM)5
    1171581  NM_054038.11  NP_473379.11 
     437643275 


    ENSEMBL Gene Tree for SCGB3A2 (if available)
    TreeFam Gene Tree for SCGB3A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCGB3A2 gene
    SCGB3A12  
    2 SIMAP similar genes for SCGB3A2 using alignment to 2 protein entries:     SG3A2_HUMAN (see all proteins):
    UGRP1    SCGB3A1

    SCGB3A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 SNPs in SCGB3A2 are shown (see all 185)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361854
    A breast cancer sample4--see VAR_0361852 K N mis40--------
    rs32173721,2
    C--147258536(+) TTGTA-/TTTTTT 1 -- int10--------
    rs1859307041,2
    --147531964(+) AAGGGC/TGTCAT 1 -- us2k10--------
    rs732613681,2
    C,F--147532073(+) TGCCTG/AAGTAG 1 -- us2k14Minor allele frequency- A:0.18WA CSA 124
    rs743197951,2
    C,F--147532100(+) AAACAA/GACCCG 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs732613721,2
    C,F--147532118(+) CCTACC/GTGGGC 1 -- us2k12Minor allele frequency- G:0.25WA 120
    rs797170831,2
    C,F--147532145(+) CTGATT/AGAGTG 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1906441591,2
    --147532184(+) TACCAA/GGACCC 1 -- us2k10--------
    rs1437831251,2
    C--147532190(+) GACCCA/GTGTAA 1 -- us2k10--------
    rs1832421031,2
    C--147532227(+) CCACTA/GGTTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCGB3A2 (147250245 - 147261756 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SCGB3A2: --

    Human Gene Mutation Database (HGMD): SCGB3A2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SCGB3A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SCGB3A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606531   
    OMIM disorders: 600807  
    6 diseases for SCGB3A2:    About MalaCards
    interstitial lung disease    asthma    allergic rhinitis    graves' disease
    rhinitis    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for SCGB3A2:
    Asthma

    SCGB3A2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SCGB3A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma allergic 67.7 7 15591807 (2), 18201431 (2), 17218572 (2), 12859445 (1)
    asthma 52.8 35 18089940 (5), 17218572 (5), 12915772 (3), 12859445 (1) (see all 6)
    genetic susceptibility 49.8 2 15591807 (1), 18201431 (1)
    inflammation 0 3 11682631 (1), 15485815 (1)

    Genetic Association Database (GAD): SCGB3A2
    Human Genome Epidemiology (HuGE) Navigator: SCGB3A2 (9 documents)

    Export disorders for SCGB3A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCGB3A2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with SCGB3A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. (PubMed id 11682631)1, 2, 3, 9 Niimi T....Kimura S. (2001)
    2. Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma. (PubMed id 18089940)1, 4, 9 Inoue K....Munakata M. (2008)
    3. Uteroglobin-related protein 1(UGRP1) gene polymorphisms and atopic asthma in the Indian population. (PubMed id 15591807)1, 4, 9 Batra J....Ghosh B. (2005)
    4. A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. (PubMed id 11813133)1, 4, 9 Niimi T....Kimura S. (2002)
    5. Update of the human secretoglobin (SCGB) gene superfa mily and an example of 'evolutionary bloom' of androgen-binding protein genes w ithin the mouse Scgb gene superfamily. (PubMed id 22155607)1, 3 Jackson B.C....Vasiliou V. (2011)
    6. Confirmation of association of chromosome 5q31-33 wit h United kingdom Caucasian Graves' disease. (PubMed id 20210668)1, 4 Simmonds M.J....Gough S.C. (2010)
    7. Analyses of associations with asthma in four asthma population samples from Canada and Australia. (PubMed id 19247692)1, 4 Daley D....Hudson T.J. (2009)
    8. Functional SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves' disease. (PubMed id 19126779)1, 4 Song H.D....Chen J.L. (2009)
    9. Association study between the IL4, IL13, IRF1 and UGRP1 genes in chromosomal 5q31 region and Chinese Graves' disease. (PubMed id 16195814)1, 4 Yang Y....Weiping T. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117156 HGNC: 18391 AceView: SCGB3A2 Ensembl:ENSG00000164265 euGenes: HUgn117156
    ECgene: SCGB3A2 H-InvDB: SCGB3A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCGB3A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCGB3A2 gene:
    Search GeneIP for patents involving SCGB3A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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