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Aliases for SCGB3A2 Gene

Aliases for SCGB3A2 Gene

  • Secretoglobin Family 3A Member 2 2 3
  • Uteroglobin-Related Protein 1 2 3 4
  • Pneumo Secretory Protein 1 2 3 4
  • Secretoglobin, Family 3A, Member 2 3 5
  • PnSP-1 3 4
  • PNSP1 3 4
  • UGRP1 3 4
  • Uteroglobin Related Protein 1 2
  • LU103 3

External Ids for SCGB3A2 Gene

Previous GeneCards Identifiers for SCGB3A2 Gene

  • GC05P147290
  • GC05P147840
  • GC05P147286
  • GC05P147238
  • GC05P142405
  • GC05P147250

Summaries for SCGB3A2 Gene

Entrez Gene Summary for SCGB3A2 Gene

  • The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010]

GeneCards Summary for SCGB3A2 Gene

SCGB3A2 (Secretoglobin Family 3A Member 2) is a Protein Coding gene. Diseases associated with SCGB3A2 include asthma. Among its related pathways are Vesicle-mediated transport and Binding and Uptake of Ligands by Scavenger Receptors. An important paralog of this gene is SCGB3A1.

Gene Wiki entry for SCGB3A2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB3A2 Gene

Genomics for SCGB3A2 Gene

Regulatory Elements for SCGB3A2 Gene

Promoters for SCGB3A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCGB3A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCGB3A2 Gene

Chromosome:
5
Start:
147,870,682 bp from pter
End:
147,882,193 bp from pter
Size:
11,512 bases
Orientation:
Plus strand

Genomic View for SCGB3A2 Gene

Genes around SCGB3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB3A2 Gene

Proteins for SCGB3A2 Gene

  • Protein details for SCGB3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PL1-SG3A2_HUMAN
    Recommended name:
    Secretoglobin family 3A member 2
    Protein Accession:
    Q96PL1

    Protein attributes for SCGB3A2 Gene

    Size:
    93 amino acids
    Molecular mass:
    10161 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for SCGB3A2 Gene

Proteomics data for SCGB3A2 Gene at MOPED

Post-translational modifications for SCGB3A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB3A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SCGB3A2 (UGRP1/SCGB3A2)

No data available for DME Specific Peptides for SCGB3A2 Gene

Domains & Families for SCGB3A2 Gene

Gene Families for SCGB3A2 Gene

Protein Domains for SCGB3A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB3A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PL1

UniProtKB/Swiss-Prot:

SG3A2_HUMAN :
  • Belongs to the secretoglobin family. UGRP subfamily.
Family:
  • Belongs to the secretoglobin family. UGRP subfamily.
genes like me logo Genes that share domains with SCGB3A2: view

Function for SCGB3A2 Gene

genes like me logo Genes that share phenotypes with SCGB3A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCGB3A2

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB3A2 Gene

Localization for SCGB3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB3A2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB3A2 Gene COMPARTMENTS Subcellular localization image for SCGB3A2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with SCGB3A2: view

Pathways & Interactions for SCGB3A2 Gene

genes like me logo Genes that share pathways with SCGB3A2: view

Pathways by source for SCGB3A2 Gene

Interacting Proteins for SCGB3A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296694%0d%0a9606.ENSP00000318916%0d%0a
Selected Interacting proteins: Q96PL1-SG3A2_HUMAN ENSP00000296694 for SCGB3A2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SCGB3A2 Gene

None

No data available for SIGNOR curated interactions for SCGB3A2 Gene

Drugs & Compounds for SCGB3A2 Gene

No Compound Related Data Available

Transcripts for SCGB3A2 Gene

mRNA/cDNA for SCGB3A2 Gene

Unigene Clusters for SCGB3A2 Gene

Secretoglobin, family 3A, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB3A2 Gene

No ASD Table

Relevant External Links for SCGB3A2 Gene

GeneLoc Exon Structure for
SCGB3A2
ECgene alternative splicing isoforms for
SCGB3A2

Expression for SCGB3A2 Gene

mRNA expression in normal human tissues for SCGB3A2 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB3A2 Gene

This gene is overexpressed in Lung (x50.2).

Protein differential expression in normal tissues from HIPED for SCGB3A2 Gene

This gene is overexpressed in Fetal gut (35.0) and Pancreatic juice (30.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCGB3A2 Gene



SOURCE GeneReport for Unigene cluster for SCGB3A2 Gene Hs.483765

mRNA Expression by UniProt/SwissProt for SCGB3A2 Gene

Q96PL1-SG3A2_HUMAN
Tissue specificity: Highly expressed in lung.
genes like me logo Genes that share expression patterns with SCGB3A2: view

Protein tissue co-expression partners for SCGB3A2 Gene

Primer Products

In Situ Assay Products

Orthologs for SCGB3A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB3A2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SCGB3A2 35
  • 84.88 (n)
  • 81.18 (a)
SCGB3A2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scgb3a2 35
  • 79.76 (n)
  • 79.76 (a)
Scgb3a2 16
Scgb3a2 36
  • 47 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCGB3A2 35
  • 99.64 (n)
  • 100 (a)
SCGB3A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scgb3a2 35
  • 82.08 (n)
  • 84.95 (a)
cow
(Bos Taurus)
Mammalia SCGB3A2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCGB3A2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
Species with no ortholog for SCGB3A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB3A2 Gene

ENSEMBL:
Gene Tree for SCGB3A2 (if available)
TreeFam:
Gene Tree for SCGB3A2 (if available)

Paralogs for SCGB3A2 Gene

Paralogs for SCGB3A2 Gene

(2) SIMAP similar genes for SCGB3A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCGB3A2: view

Variants for SCGB3A2 Gene

Sequence variations from dbSNP and Humsavar for SCGB3A2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_036185 A breast cancer sample
rs1368408 -- 147,878,599(+) TGTTT(A/G)GTGAG upstream-variant-2KB
rs2163787 -- 147,880,153(+) CGTGT(A/G)TGCTC intron-variant
rs2278376 -- 147,878,932(+) GTAAG(A/C)CTTGC intron-variant
rs2116805 -- 147,879,842(+) CTACA(A/C)TGGCA intron-variant

Variation tolerance for SCGB3A2 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB3A2 Gene

HapMap Linkage Disequilibrium report
SCGB3A2
Human Gene Mutation Database (HGMD)
SCGB3A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB3A2 Gene

Disorders for SCGB3A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCGB3A2 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SCGB3A2

Genetic Association Database (GAD)
SCGB3A2
Human Genome Epidemiology (HuGE) Navigator
SCGB3A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCGB3A2
genes like me logo Genes that share disorders with SCGB3A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB3A2 Gene

Publications for SCGB3A2 Gene

  1. UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. (PMID: 11682631) Niimi T. … Kimura S. (Mol. Endocrinol. 2001) 2 3 4 23 67
  2. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 3
  3. Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma. (PMID: 18089940) Inoue K. … Munakata M. (Allergol Int 2008) 3 23
  4. Uteroglobin-related protein 1 gene -112G/a polymorphism and atopic asthma in Sicilian children. (PMID: 18201431) Rigoli L. … Salpietro C.D. (Allergy Asthma Proc 2007) 3 23
  5. Uteroglobin-related protein 1(UGRP1) gene polymorphisms and atopic asthma in the Indian population. (PMID: 15591807) Batra J. … Ghosh B. (Int. Arch. Allergy Immunol. 2005) 3 23

Products for SCGB3A2 Gene

Sources for SCGB3A2 Gene

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