Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SCGB3A2 Gene

Aliases for SCGB3A2 Gene

  • Secretoglobin Family 3A Member 2 2 3 5
  • Uteroglobin-Related Protein 1 2 3 4
  • Pneumo Secretory Protein 1 2 3 4
  • PnSP-1 3 4
  • PNSP1 3 4
  • UGRP1 3 4
  • Uteroglobin Related Protein 1 2
  • LU103 3

External Ids for SCGB3A2 Gene

Previous GeneCards Identifiers for SCGB3A2 Gene

  • GC05P147290
  • GC05P147840
  • GC05P147286
  • GC05P147238
  • GC05P142405
  • GC05P147250

Summaries for SCGB3A2 Gene

Entrez Gene Summary for SCGB3A2 Gene

  • The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010]

GeneCards Summary for SCGB3A2 Gene

SCGB3A2 (Secretoglobin Family 3A Member 2) is a Protein Coding gene. Diseases associated with SCGB3A2 include Asthma and Asthma Susceptibility, Scgb3a2-Related. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport. An important paralog of this gene is SCGB3A1.

Gene Wiki entry for SCGB3A2 Gene

Additional gene information for SCGB3A2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB3A2 Gene

Genomics for SCGB3A2 Gene

Regulatory Elements for SCGB3A2 Gene

Enhancers for SCGB3A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H147872 1 Ensembl ENCODE dbSUPER 9.9 +3.7 3740 3.2 POLR2A POU5F1 EZH2 SCGB3A2 ENSG00000251320 ENSG00000248362
GH05H147905 0.9 Ensembl ENCODE 8.7 +35.7 35681 1.7 TBP SMARCC1 JUN HLF CEBPB EP300 ATF2 GATA3 JUND CEBPA ENSG00000251320 SCGB3A2 C5orf46
GH05H147868 0.7 ENCODE dbSUPER 10.9 -0.9 -926 1.7 POLR2A POU5F1 SCGB3A2 GC05P147856
GH05H147873 0.4 dbSUPER 10.9 +1.7 1657 0.4 POLR2A EZH2 SCGB3A2 ENSG00000251320 ENSG00000248362
GH05H147898 0.5 ENCODE 6 +28.5 28546 1.5 JUND POLR2A EP300 SCGB3A2 SPINK1 C5orf46 ENSG00000251320
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCGB3A2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SCGB3A2 Gene

Genomic Locations for SCGB3A2 Gene
11,512 bases
Plus strand

Genomic View for SCGB3A2 Gene

Genes around SCGB3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB3A2 Gene

Proteins for SCGB3A2 Gene

  • Protein details for SCGB3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secretoglobin family 3A member 2
    Protein Accession:

    Protein attributes for SCGB3A2 Gene

    93 amino acids
    Molecular mass:
    10161 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for SCGB3A2 Gene

Post-translational modifications for SCGB3A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB3A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB3A2 Gene

Domains & Families for SCGB3A2 Gene

Gene Families for SCGB3A2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SCGB3A2 Gene


Suggested Antigen Peptide Sequences for SCGB3A2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the secretoglobin family. UGRP subfamily.
  • Belongs to the secretoglobin family. UGRP subfamily.
genes like me logo Genes that share domains with SCGB3A2: view

Function for SCGB3A2 Gene

genes like me logo Genes that share phenotypes with SCGB3A2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB3A2 Gene

Localization for SCGB3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB3A2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB3A2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0071682 endocytic vesicle lumen TAS --
genes like me logo Genes that share ontologies with SCGB3A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCGB3A2 Gene

Pathways & Interactions for SCGB3A2 Gene

genes like me logo Genes that share pathways with SCGB3A2: view

Pathways by source for SCGB3A2 Gene

Interacting Proteins for SCGB3A2 Gene

Gene Ontology (GO) - Biological Process for SCGB3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with SCGB3A2: view

No data available for SIGNOR curated interactions for SCGB3A2 Gene

Drugs & Compounds for SCGB3A2 Gene

No Compound Related Data Available

Transcripts for SCGB3A2 Gene

mRNA/cDNA for SCGB3A2 Gene

Unigene Clusters for SCGB3A2 Gene

Secretoglobin, family 3A, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB3A2 Gene

No ASD Table

Relevant External Links for SCGB3A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCGB3A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCGB3A2 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB3A2 Gene

This gene is overexpressed in Lung (x50.2).

Protein differential expression in normal tissues from HIPED for SCGB3A2 Gene

This gene is overexpressed in Fetal gut (35.0) and Pancreatic juice (30.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCGB3A2 Gene

Protein tissue co-expression partners for SCGB3A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCGB3A2 Gene:


SOURCE GeneReport for Unigene cluster for SCGB3A2 Gene:


mRNA Expression by UniProt/SwissProt for SCGB3A2 Gene:

Tissue specificity: Highly expressed in lung.

Evidence on tissue expression from TISSUES for SCGB3A2 Gene

  • Lung(4.8)
genes like me logo Genes that share expression patterns with SCGB3A2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB3A2 Gene

Orthologs for SCGB3A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB3A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCGB3A2 33 34
  • 99.64 (n)
(Canis familiaris)
Mammalia SCGB3A2 33 34
  • 84.88 (n)
(Bos Taurus)
Mammalia SCGB3A2 34
  • 84 (a)
(Rattus norvegicus)
Mammalia Scgb3a2 33
  • 82.08 (n)
(Mus musculus)
Mammalia Scgb3a2 33 16 34
  • 79.76 (n)
(Monodelphis domestica)
Mammalia SCGB3A2 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
Species where no ortholog for SCGB3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB3A2 Gene

Gene Tree for SCGB3A2 (if available)
Gene Tree for SCGB3A2 (if available)

Paralogs for SCGB3A2 Gene

Paralogs for SCGB3A2 Gene

(2) SIMAP similar genes for SCGB3A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCGB3A2: view

Variants for SCGB3A2 Gene

Sequence variations from dbSNP and Humsavar for SCGB3A2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_036185 A breast cancer sample
rs1001384711 -- 147,880,779(+) GCATC(C/T)TTGTC intron-variant
rs1001958380 -- 147,879,125(+) TACAT(A/C)CTACA intron-variant
rs1002072924 -- 147,879,402(+) ATAGG(C/G)ATTGG intron-variant
rs1002458498 -- 147,881,409(+) CCCAG(A/G)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCGB3A2 Gene

Variant ID Type Subtype PubMed ID
nsv1028477 CNV loss 25217958
nsv1021356 CNV gain 25217958
esv3570488 CNV loss 25503493

Variation tolerance for SCGB3A2 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB3A2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB3A2 Gene

Disorders for SCGB3A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SCGB3A2 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • asthma, protection against
asthma susceptibility, scgb3a2-related
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SCGB3A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCGB3A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB3A2 Gene

Publications for SCGB3A2 Gene

  1. UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. (PMID: 11682631) Niimi T … Kimura S (Molecular endocrinology (Baltimore, Md.) 2001) 2 3 4 22 60
  2. Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma. (PMID: 18089940) Inoue K … Munakata M (Allergology international : official journal of the Japanese Society of Allergology 2008) 3 22 45 60
  3. Uteroglobin-related protein 1(UGRP1) gene polymorphisms and atopic asthma in the Indian population. (PMID: 15591807) Batra J … Ghosh B (International archives of allergy and immunology 2005) 3 22 45 60
  4. A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. (PMID: 11813133) Niimi T … Kimura S (American journal of human genetics 2002) 3 22 45 60
  5. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson BC … Vasiliou V (Human genomics 2011) 2 3 60

Products for SCGB3A2 Gene

Sources for SCGB3A2 Gene

Loading form....