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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCGB3A1 Gene

protein-coding   GIFtS: 47
GCID: GC05M180017

secretoglobin, family 3A, member 1

 Explore 13 diseases affiliated with
SCGB3A1 via our new
 Human Malady Compendium 
Biological research products
for SCGB3A1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Secretoglobin, Family 3A, Member 11 2     High In Normal 12 3
HIN11 2 3 5     Pneumo Secretory Protein 22 3
PnSP-21 2 3     Uteroglobin-Related Protein 22 3
UGRP21 2 3     Cytokine High In Normal-12
HIN-11 2     Secretoglobin Family 3A Member 12
LU1051 2     PNSP23
Cytokine HIN-12 3     

External Ids:    HGNC: 183841   Entrez Gene: 923042   Ensembl: ENSG000001610557   OMIM: 6065005   UniProtKB: Q96QR13   

Export aliases for SCGB3A1 gene to outside databases

Previous GC identifers: GC05U990164 GC05M180995 GC05M180081 GC05M180126 GC05M179949 GC05M174741


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SG3A1_HUMAN, Q96QR1
Function: Potential growth inhibitory cytokine

Gene Wiki entry for SCGB3A1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCGB3A1 gene promoter:
         E2F-4   E2F-3a   GR   GR-beta   E2F-2   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCGB3A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCGB3A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCGB3A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35-qter   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35-qter

SCGB3A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCGB3A1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M180017:  view genomic region     (about GC identifiers)

Start:
180,017,103 bp from pter      End:
180,018,540 bp from pter
Size:
1,438 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SG3A1_HUMAN, Q96QR1 (See protein sequence)
Recommended Name: Secretoglobin family 3A member 1 precursor  
Size: 104 amino acids; 10100 Da
Subcellular location: Secreted
Secondary accessions: Q96PL0

Explore the universe of human proteins at neXtProt for SCGB3A1: NX_Q96QR1

SCGB3A1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_443095.2  
ENSEMBL proteins: 
 ENSP00000292641  

Human Recombinant Protein Products: 
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Uscn Proteins for SCGB3A1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS11481438
GO:0005615extracellular space IEA--


SCGB3A1 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for SCGB3A1


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96QR1

UniProtKB/Swiss-Prot: SG3A1_HUMAN, Q96QR1
Similarity: Belongs to the secretoglobin family. UGRP subfamily


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: SG3A1_HUMAN, Q96QR1
Function: Potential growth inhibitory cytokine

miRNA
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Inhib. RNA
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCGB3A1

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In Situ Assay
Products:
   

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SCGB3A1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity NAS11481438


SCGB3A1 for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-out Scgb3a1tm1Lex for SCGB3A1
     1 MGI phenotypic allele for Scgb3a1 (no phenotypes)

SCGB3A1 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCGB3A1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SCGB3A1 (Q96QR13 ENSP000002926414) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MARCOQ9UEW33, ENSP000003189164I2D: score=2 STRING: ENSP00000318916
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030308negative regulation of cell growth NAS11481438
GO:0042127regulation of cell proliferation NAS11481438


SCGB3A1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SCGB3A1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SCGB3A1
1 Novoseek chemical compound relationship for SCGB3A1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
5-aza-2'deoxycytidine 59.4 1 15472908 (1)

Search CenterWatch for drugs/clinical trials and news about SCGB3A1 / SG3A1 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCGB3A1 gene: 
NM_052863.2  

Unigene Cluster for SCGB3A1:

Secretoglobin, family 3A, member 1
Hs.62492  [show with all ESTs]
Unigene Representative Sequence: BM921624
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000292641(uc003mly.3) ENST00000512120

miRNA
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hsa-miR-3655 hsa-miR-3202
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCGB3A1 (see all 7)
OriGene shRNA RFP: SCGB3A1
OriGene siRNA: SCGB3A1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCGB3A1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCGB3A1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCGB3A1 
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCGB3A1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCGB3A1

Additional cDNA sequence: 

AF086152.1 AF313458.1 AF436839.1 AY040564.1 AY359064.1 BC029176.1 BC072673.1 

3 DOTS entries:

DT.309839  DT.97841130  DT.75104735 

24/55 AceView cDNA sequences (see all 55):

NM_052863 BM920794 BM977626 BM982925 AF436839 AI685860 AF086152 BM920793 
BU679439 BM975405 BC029176 AI745557 BU607563 AY359064 AI858018 BC072673 
BQ286746 BM980649 BM982112 AI744099 BI820788 AI333740 AI187341 AI936195 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCGB3A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCTCGCCG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

SCGB3A1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
OvaryPrimary FollicleGranulosa CellsOvary
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See SCGB3A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCGB3A1

SOURCE GeneReport for Unigene cluster: Hs.62492

UniProtKB/Swiss-Prot: SG3A1_HUMAN, Q96QR1
Tissue specificity: Highly expressed in breast tissues. Absent in breast cancer cell lines

    SABiosciences Custom PCR Arrays for SCGB3A1
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCGB3A1
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SCGB3A1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for SCGB3A1 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Scgb3a11 , 5 secretoglobin, family 3A, member 11, 5 69.64(n)1
60.4(a)1
  11 (29.75 cM)5
686621  NM_054037.11  NP_473378.11 
 496636105 


ENSEMBL Gene Tree for SCGB3A1 (if available)
TreeFam Gene Tree for SCGB3A1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SCGB3A1 gene
SCGB3A22  
2 SIMAP similar genes for SCGB3A1 using alignment to 1 protein entry:     SG3A1_HUMAN:
SCGB3A2    UGRP1

SCGB3A1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/45 NCBI SNPs in SCGB3A1 are shown (see all 45    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1404077321,2
--180016636(+) TCTCCA/GCTAGA 1 -- int10--------
rs3686861,2
C,F,O,H,--180016644(+) AGAGTA/GGAAGG 1 -- int124Minor allele frequency- G:0.16MN NS EA NA CSA WA 2889
rs1165065241,2
F,--180016749(+) ATTCCG/AAGGAA 1 -- int11Minor allele frequency- A:0.02WA 118
rs1917859731,2
--180016833(+) TTCTCA/GCCAGT 1 -- int10--------
rs1161196291,2
--180017069(+) ACAGGG/AATCAG 1 -- int11Minor allele frequency- A:0.01WA 118
rs1148571931,2
F,--180017351(+) GAGCGG/AGGCGG 1 -- int12Minor allele frequency- A:0.07WA EA 238
rs1156825901,2
F,--180017352(+) AGCGGG/AGCGGT 1 -- int12Minor allele frequency- A:0.07WA EA 238
rs1835863451,2
--180017388(+) CACCCA/GCGCGG 1 -- int10--------
rs4503831,2
C,A,--180017399(+) GGCCAT/CCTCCG 1 -- int13Minor allele frequency- C:0.04NA WA 122
rs1152091631,2
F,--180017490(+) GAGGGG/CCAGGA 1 -- int12Minor allele frequency- C:0.05NA EA 240

HapMap Linkage Disequilibrium report for SCGB3A1 (180017103 - 180018540 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SCGB3A1: --

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCGB3A1 for disorders           About GeneDecksing

OMIM gene information: 606500    OMIM disorders: --

13 diseases for SCGB3A1:    About MalaCards
sporadic breast cancer    neuritis    breast cancer    testicular cancer
breast carcinoma    lung cancer    ovarian carcinoma    gastric cancer
carcinoma    influenza    esophagitis    cervicitis
neuroblastoma

7 Novoseek disease relationships for SCGB3A1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
breast carcinoma 44.1 5 15383627 (2), 12727813 (1), 11481438 (1)
small cell lung cancer 42.4 2 15383627 (1)
primary tumor 40.1 3 19956520 (1), 11481438 (1), 15472908 (1)
nsclc 31.8 2 14977834 (1), 15472908 (1)
tumors 25.4 31 15383627 (6), 12727813 (5), 14977834 (2), 19098448 (2) (see all 8)
breast cancer 25.3 13 12727813 (2), 11481438 (2), 15472908 (2), 19956520 (1)
cancer 0 5 12727813 (1), 15383627 (1), 19098448 (1)

Human Genome Epidemiology (HuGE) Navigator: SCGB3A1 (1 document)

Export disorders for SCGB3A1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SCGB3A1 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with SCGB3A1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. (PubMed id 11481438)1, 2, 3, 9 Krop I.E....Polyak K. (2001)
  2. Update of the human secretoglobin (SCGB) gene superfa mily and an example of 'evolutionary bloom' of androgen-binding protein genes w ithin the mouse Scgb gene superfamily. (PubMed id 22155607)1, 3 Jackson B.C....Vasiliou V. (2011)
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  6. UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. (PubMed id 11682631)2, 3 Niimi T....Kimura S. (2001)
  7. Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types. (PubMed id 15383627)1, 9 Krop I....Polyak K. (2004)
  8. Promoter methylation of HIN-1 in the progression to esophageal squamous cancer. (PubMed id 19098448)1, 9 Guo M....Carraway H.E. (2008)
  9. Lack of HIN-1 methylation in BRCA1-linked and 'B RCA1-like' breast tumors. (PubMed id 12727813)1, 9 Krop I....Polyak K. (2003)
  10. Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family. (PubMed id 12438750)1, 9 Niimi T....Kimura S. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 92304 HGNC: 18384 AceView: SCGB3A1 Ensembl:ENSG00000161055 euGenes: HUgn92304
ECgene: SCGB3A1 H-InvDB: SCGB3A1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SCGB3A1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SCGB3A1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SCGB3A1 gene:
Search GeneIP for patents involving SCGB3A1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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