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Aliases for SCGB3A1 Gene

Aliases for SCGB3A1 Gene

  • Secretoglobin Family 3A Member 1 2 3 5
  • Pneumo Secretory Protein 2 2 3 4
  • Uteroglobin-Related Protein 2 3 4
  • Cytokine High In Normal-1 2 3
  • High In Normal 1 3 4
  • Cytokine HIN-1 3 4
  • PnSP-2 3 4
  • UGRP2 3 4
  • HIN1 3 4
  • HIN-1 3
  • LU105 3
  • PNSP2 4

External Ids for SCGB3A1 Gene

Previous GeneCards Identifiers for SCGB3A1 Gene

  • GC05U990164
  • GC05M180995
  • GC05M180081
  • GC05M180126
  • GC05M179949
  • GC05M180017
  • GC05M174741

Summaries for SCGB3A1 Gene

GeneCards Summary for SCGB3A1 Gene

SCGB3A1 (Secretoglobin Family 3A Member 1) is a Protein Coding gene. Diseases associated with SCGB3A1 include Breast Cancer. GO annotations related to this gene include cytokine activity. An important paralog of this gene is SCGB3A2.

UniProtKB/Swiss-Prot for SCGB3A1 Gene

  • Potential growth inhibitory cytokine.

Gene Wiki entry for SCGB3A1 Gene

Additional gene information for SCGB3A1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB3A1 Gene

Genomics for SCGB3A1 Gene

Regulatory Elements for SCGB3A1 Gene

Enhancers for SCGB3A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H180560 0.9 ENCODE 52.4 +29.1 29051 3.6 HDAC1 HDGF PKNOX1 TBL1XR1 ARNT TCF12 GATA2 ZNF143 SIRT6 ATF7 SCGB3A1 FLT4 CNOT6 ENSG00000248367 GC05P180580 LOC100329129
GH05H180554 1 ENCODE 40.5 +36.3 36269 2.5 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 FOS ATF7 NCOA1 SCGB3A1 LOC100329129 GC05P180580
GH05H180548 0.7 ENCODE 29.3 +42.8 42820 1.2 HDAC1 TAL1 BACH1 FOSL1 ZNF316 GATA2 NFE2 MAFK NFE2L2 SMARCE1 SCGB3A1 LOC100329129 GC05P180580
GH05H180493 1.1 ENCODE 7.1 +96.2 96174 4.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YBX1 ZNF2 YY1 ZNF143 HNRNPH1 MAML1 MRNIP ENSG00000233937 TRIM52 ZFP62 RUFY1 RACK1 LOC100420514 OR2AI1P
GH05H180518 0.8 Ensembl 7.2 +72.4 72439 0.6 CTCF HINFP ZNF175 PYGO2 ZNF644 ZNF507 YY1 ZNF766 POLR2A ZNF639 ZFP62 ENSG00000233937 LOC100996419 LOC105377763 TRIM52 RN7SKP150 SCGB3A1 LOC100329129 CNOT6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCGB3A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SCGB3A1 Gene

Genomic Locations for SCGB3A1 Gene
1,438 bases
Minus strand

Genomic View for SCGB3A1 Gene

Genes around SCGB3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB3A1 Gene

Proteins for SCGB3A1 Gene

  • Protein details for SCGB3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secretoglobin family 3A member 1
    Protein Accession:
    Secondary Accessions:
    • Q96PL0

    Protein attributes for SCGB3A1 Gene

    104 amino acids
    Molecular mass:
    10100 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCGB3A1 Gene

Post-translational modifications for SCGB3A1 Gene

No Post-translational modifications

Other Protein References for SCGB3A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB3A1 Gene

Domains & Families for SCGB3A1 Gene

Gene Families for SCGB3A1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SCGB3A1 Gene


Suggested Antigen Peptide Sequences for SCGB3A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the secretoglobin family. UGRP subfamily.
  • Belongs to the secretoglobin family. UGRP subfamily.
genes like me logo Genes that share domains with SCGB3A1: view

Function for SCGB3A1 Gene

Molecular function for SCGB3A1 Gene

UniProtKB/Swiss-Prot Function:
Potential growth inhibitory cytokine.

Gene Ontology (GO) - Molecular Function for SCGB3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 11481438
genes like me logo Genes that share ontologies with SCGB3A1: view
genes like me logo Genes that share phenotypes with SCGB3A1: view

Animal Model Products

miRNA for SCGB3A1 Gene

miRTarBase miRNAs that target SCGB3A1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCGB3A1 Gene

Localization for SCGB3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB3A1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB3A1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IDA 11481438
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SCGB3A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCGB3A1 Gene

Pathways & Interactions for SCGB3A1 Gene

SuperPathways for SCGB3A1 Gene

No Data Available

Interacting Proteins for SCGB3A1 Gene

Gene Ontology (GO) - Biological Process for SCGB3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth NAS 11481438
GO:0042127 regulation of cell proliferation NAS 11481438
GO:1901741 positive regulation of myoblast fusion IEA --
genes like me logo Genes that share ontologies with SCGB3A1: view

No data available for Pathways by source and SIGNOR curated interactions for SCGB3A1 Gene

Drugs & Compounds for SCGB3A1 Gene

(1) Additional Compounds for SCGB3A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SCGB3A1: view

Transcripts for SCGB3A1 Gene

mRNA/cDNA for SCGB3A1 Gene

Unigene Clusters for SCGB3A1 Gene

Secretoglobin, family 3A, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB3A1 Gene

No ASD Table

Relevant External Links for SCGB3A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCGB3A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCGB3A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCGB3A1 Gene

This gene is overexpressed in Minor Salivary Gland (x24.1), Cervix - Endocervix (x12.0), and Lung (x8.1).

Protein differential expression in normal tissues from HIPED for SCGB3A1 Gene

This gene is overexpressed in Fetal gut (56.9) and Plasma (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCGB3A1 Gene

Protein tissue co-expression partners for SCGB3A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCGB3A1 Gene:


SOURCE GeneReport for Unigene cluster for SCGB3A1 Gene:


mRNA Expression by UniProt/SwissProt for SCGB3A1 Gene:

Tissue specificity: Highly expressed in breast tissues. Absent in breast cancer cell lines.

Evidence on tissue expression from TISSUES for SCGB3A1 Gene

  • Nervous system(4)
  • Lung(3.3)
genes like me logo Genes that share expression patterns with SCGB3A1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB3A1 Gene

Orthologs for SCGB3A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB3A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCGB3A1 33 34
  • 98.08 (n)
(Rattus norvegicus)
Mammalia Scgb3a1 33
  • 70.63 (n)
(Mus musculus)
Mammalia Scgb3a1 33 16 34
  • 69.64 (n)
(Monodelphis domestica)
Mammalia SCGB3A1 34
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
Species where no ortholog for SCGB3A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB3A1 Gene

Gene Tree for SCGB3A1 (if available)
Gene Tree for SCGB3A1 (if available)

Paralogs for SCGB3A1 Gene

Paralogs for SCGB3A1 Gene

(2) SIMAP similar genes for SCGB3A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCGB3A1: view

Variants for SCGB3A1 Gene

Sequence variations from dbSNP and Humsavar for SCGB3A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000275961 -- 180,591,282(+) GTGGC(A/G)GAGCC intron-variant
rs1000423769 -- 180,593,293(+) ATATT(A/C)TAATG upstream-variant-2KB
rs1000558855 -- 180,590,106(+) GAGCT(A/G)CTCTT utr-variant-3-prime
rs1000610987 -- 180,590,354(+) CGGGG(A/C)GGTTC intron-variant
rs1000732168 -- 180,591,565(+) CCCGC(C/G)CTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SCGB3A1 Gene

Variant ID Type Subtype PubMed ID
nsv509111 CNV insertion 20534489
nsv1026417 CNV gain 25217958
esv2762572 CNV gain 21179565

Variation tolerance for SCGB3A1 Gene

Gene Damage Index Score: 0.54; 11.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB3A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB3A1 Gene

Disorders for SCGB3A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCGB3A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SCGB3A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCGB3A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB3A1 Gene

Publications for SCGB3A1 Gene

  1. HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. (PMID: 11481438) Krop IE … Polyak K (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 22 60
  2. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson BC … Vasiliou V (Human genomics 2011) 2 3 60
  3. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 45 60
  4. Promoter methylation of HIN-1 in the progression to esophageal squamous cancer. (PMID: 19098448) Guo M … Carraway HE (Epigenetics 2008) 3 22 60
  5. DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. (PMID: 17623056) Wu Q … Lind GE (Molecular cancer 2007) 3 22 60

Products for SCGB3A1 Gene

Sources for SCGB3A1 Gene

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