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Aliases for SCGB2B2 Gene

Aliases for SCGB2B2 Gene

  • Secretoglobin Family 2B Member 2 2 3 5
  • Secretoglobin-Like Protein 3 4
  • SCGB4A2 3 4
  • SCGBL 3 4
  • Secretoglobin-Like 2

External Ids for SCGB2B2 Gene

Previous HGNC Symbols for SCGB2B2 Gene

  • SCGBL

Previous GeneCards Identifiers for SCGB2B2 Gene

  • GC19M035085

Summaries for SCGB2B2 Gene

GeneCards Summary for SCGB2B2 Gene

SCGB2B2 (Secretoglobin Family 2B Member 2) is a Protein Coding gene.

Additional gene information for SCGB2B2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB2B2 Gene

Genomics for SCGB2B2 Gene

GeneHancer (GH) Regulatory Elements for SCGB2B2 Gene

Promoters and enhancers for SCGB2B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I034676 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -2.0 -1957 2.5 PKNOX1 SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF213 ZNF302 ZNF416 ZNF207 ZNF302 ENSG00000279329 GC19P034675 PIR41849 SCGB2B2 PIR50277 GC19M034683 TMEM147-AS1 ZNF599 HAUS5
GH19I035066 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.1 -392.3 -392307 3.2 HDGF ARID4B SIN3A FEZF1 ZNF2 YY1 E2F8 ZNF207 ZNF143 KLF13 HPN TMEM147-AS1 SCN1B LSM14A RBM42 ENSG00000267049 KMT2B HAUS5 ZBTB32 ZNF599
GH19I034170 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.2 +502.6 502585 5.2 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 NFYC ZC3H11A SSRP1 ZNF610 LSM14A GC19M034171 ZNF599 ZNF792 KIAA0355 ZNF302 ZNF181 ENSG00000271032 WTIP ZNF30
GH19I034672 Enhancer 0.8 ENCODE 0.8 +2.0 2041 2.8 ELF3 FOXA2 MLX ARID4B RARA ETS1 ATF7 CREM THAP11 SP5 ZNF302 ZNF181 ZNF599 SCGB2B2 SCGB2B3P
GH19I034774 Enhancer 0.3 FANTOM5 1.4 -98.5 -98500 0.1 ZNF599 LOC105372375 FAM187B SCGB2B2 ENSG00000270281
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SCGB2B2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SCGB2B2 Gene

Genomic Locations for SCGB2B2 Gene
chr19:34,576,740-34,675,731
(GRCh38/hg38)
Size:
98,992 bases
Orientation:
Minus strand
chr19:35,084,234-35,166,604
(GRCh37/hg19)

Genomic View for SCGB2B2 Gene

Genes around SCGB2B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB2B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB2B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB2B2 Gene

Proteins for SCGB2B2 Gene

  • Protein details for SCGB2B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0G5-SC2B2_HUMAN
    Recommended name:
    Secretoglobin family 2B member 2
    Protein Accession:
    Q4G0G5

    Protein attributes for SCGB2B2 Gene

    Size:
    96 amino acids
    Molecular mass:
    10563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCGB2B2 Gene

Post-translational modifications for SCGB2B2 Gene

No Post-translational modifications

Other Protein References for SCGB2B2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB2B2 Gene

Domains & Families for SCGB2B2 Gene

Gene Families for SCGB2B2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SCGB2B2 Gene

Suggested Antigen Peptide Sequences for SCGB2B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0G5

UniProtKB/Swiss-Prot:

SC2B2_HUMAN :
  • Belongs to the secretoglobin family.
Family:
  • Belongs to the secretoglobin family.
genes like me logo Genes that share domains with SCGB2B2: view

Function for SCGB2B2 Gene

Phenotypes From GWAS Catalog for SCGB2B2 Gene

Phenotypes for SCGB2B2 Gene

GenomeRNAi human phenotypes for SCGB2B2:
genes like me logo Genes that share phenotypes with SCGB2B2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB2B2 Gene

Localization for SCGB2B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB2B2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB2B2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SCGB2B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCGB2B2 Gene

Pathways & Interactions for SCGB2B2 Gene

SuperPathways for SCGB2B2 Gene

No Data Available

Interacting Proteins for SCGB2B2 Gene

Gene Ontology (GO) - Biological Process for SCGB2B2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCGB2B2 Gene

Drugs & Compounds for SCGB2B2 Gene

No Compound Related Data Available

Transcripts for SCGB2B2 Gene

mRNA/cDNA for SCGB2B2 Gene

Unigene Clusters for SCGB2B2 Gene

Secretoglobin, family 2B, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2B2 Gene

No ASD Table

Relevant External Links for SCGB2B2 Gene

GeneLoc Exon Structure for
SCGB2B2
ECgene alternative splicing isoforms for
SCGB2B2

Expression for SCGB2B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCGB2B2 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB2B2 Gene

This gene is overexpressed in Testis (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of SCGB2B2 Gene:

SCGB2B2

SOURCE GeneReport for Unigene cluster for SCGB2B2 Gene:

Hs.656990
genes like me logo Genes that share expression patterns with SCGB2B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB2B2 Gene

Orthologs for SCGB2B2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SCGB2B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGBL 33
  • 96.47 (n)
SCGB2B2 34
  • 96 (a)
OneToOne
Species where no ortholog for SCGB2B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB2B2 Gene

ENSEMBL:
Gene Tree for SCGB2B2 (if available)
TreeFam:
Gene Tree for SCGB2B2 (if available)

Paralogs for SCGB2B2 Gene

Pseudogenes.org Pseudogenes for SCGB2B2 Gene

genes like me logo Genes that share paralogs with SCGB2B2: view

No data available for Paralogs for SCGB2B2 Gene

Variants for SCGB2B2 Gene

Sequence variations from dbSNP and Humsavar for SCGB2B2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000293843 -- 34,593,918(-) G/C intron_variant
rs1000546319 -- 34,591,412(-) G/T 3_prime_UTR_variant
rs1001029817 -- 34,592,826(-) G/A 3_prime_UTR_variant
rs1001078943 -- 34,592,658(-) C/T 3_prime_UTR_variant
rs1001373462 -- 34,590,598(-) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SCGB2B2 Gene

Variant ID Type Subtype PubMed ID
esv2718486 CNV deletion 23290073
esv3329051 OTHER inversion 20981092
esv5547 OTHER inversion 19470904
nsv1071533 CNV deletion 25765185

Variation tolerance for SCGB2B2 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCGB2B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB2B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB2B2 Gene

Disorders for SCGB2B2 Gene

Additional Disease Information for SCGB2B2

No disorders were found for SCGB2B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCGB2B2 Gene

Publications for SCGB2B2 Gene

  1. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson BC … Vasiliou V (Human genomics 2011) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SCGB2B2 Gene

Sources for SCGB2B2 Gene

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