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Aliases for SCGB2A2 Gene

Aliases for SCGB2A2 Gene

  • Secretoglobin, Family 2A, Member 2 2 3
  • Mammaglobin 1 2 3
  • MGB1 3 4
  • UGB2 3 4
  • Secretoglobin Family 2A Member 2 4
  • Mammaglobin A 2
  • Mammaglobin-A 3
  • Mammaglobin-1 4
  • MGB1, 6

External Ids for SCGB2A2 Gene

Previous HGNC Symbols for SCGB2A2 Gene

  • MGB1

Previous GeneCards Identifiers for SCGB2A2 Gene

  • GC11P064551
  • GC11P063613
  • GC11P061812
  • GC11P061794
  • GC11P062038
  • GC11P058366

Summaries for SCGB2A2 Gene

GeneCards Summary for SCGB2A2 Gene

SCGB2A2 (Secretoglobin, Family 2A, Member 2) is a Protein Coding gene. Diseases associated with SCGB2A2 include breast cancer. GO annotations related to this gene include steroid binding. An important paralog of this gene is SCGB2A1.

Gene Wiki entry for SCGB2A2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB2A2 Gene

Genomics for SCGB2A2 Gene

Regulatory Elements for SCGB2A2 Gene

Genomic Location for SCGB2A2 Gene

Start:
62,270,155 bp from pter
End:
62,273,160 bp from pter
Size:
3,006 bases
Orientation:
Plus strand

Genomic View for SCGB2A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCGB2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB2A2 Gene

Proteins for SCGB2A2 Gene

  • Protein details for SCGB2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13296-SG2A2_HUMAN
    Recommended name:
    Mammaglobin-A
    Protein Accession:
    Q13296
    Secondary Accessions:
    • A1A522
    • Q86WH8

    Protein attributes for SCGB2A2 Gene

    Size:
    93 amino acids
    Molecular mass:
    10499 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCGB2A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCGB2A2 Gene

Proteomics data for SCGB2A2 Gene at MOPED

Post-translational modifications for SCGB2A2 Gene

Other Protein References for SCGB2A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB2A2 Gene

Domains for SCGB2A2 Gene

Gene Families for SCGB2A2 Gene

HGNC:
  • SCGB :Secretoglobins

Protein Domains for SCGB2A2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB2A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13296

UniProtKB/Swiss-Prot:

SG2A2_HUMAN :
  • Q13296
Family:
  • Belongs to the secretoglobin family. Lipophilin subfamily.
genes like me logo Genes that share domains with SCGB2A2: view

Function for SCGB2A2 Gene

Gene Ontology (GO) - Molecular Function for SCGB2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SCGB2A2: view

miRNA for SCGB2A2 Gene

miRTarBase miRNAs that target SCGB2A2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCGB2A2 Gene

Localization for SCGB2A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB2A2 Gene COMPARTMENTS Subcellular localization image for SCGB2A2 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SCGB2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SCGB2A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SCGB2A2 Gene

Pathways for SCGB2A2 Gene

SuperPathways for SCGB2A2 Gene

No Data Available

Interacting Proteins for SCGB2A2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000227918%0d%0a9606.ENSP00000245932%0d%0a9606.ENSP00000244926%0d%0a
Selected Interacting proteins: ENSP00000227918 Q13296-SG2A2_HUMAN for SCGB2A2 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for SCGB2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SCGB2A2: view

No data available for Pathways by source for SCGB2A2 Gene

Compounds for SCGB2A2 Gene

(1) Novoseek inferred chemical compound relationships for SCGB2A2 Gene

Compound -log(P) Hits PubMed IDs
estrogen 23.9 6
genes like me logo Genes that share compounds with SCGB2A2: view

Transcripts for SCGB2A2 Gene

mRNA/cDNA for SCGB2A2 Gene

Unigene Clusters for SCGB2A2 Gene

Secretoglobin, family 2A, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2A2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
SP1: -
SP2: - -
SP3:

Relevant External Links for SCGB2A2 Gene

GeneLoc Exon Structure for
SCGB2A2
ECgene alternative splicing isoforms for
SCGB2A2

Expression for SCGB2A2 Gene

mRNA expression in normal human tissues for SCGB2A2 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB2A2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (15.5), Skin - Not Sun Exposed (Suprapubic) (14.0), Breast - Mammary Tissue (13.0), and Cervix - Endocervix (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCGB2A2 Gene

SOURCE GeneReport for Unigene cluster for SCGB2A2 Gene Hs.46452

mRNA Expression by UniProt/SwissProt for SCGB2A2 Gene

Q13296-SG2A2_HUMAN
Tissue specificity: Mammary gland specific. Over-expressed in breast cancer
genes like me logo Genes that share expressions with SCGB2A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCGB2A2 Gene

Orthologs for SCGB2A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB2A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB2A2 35
  • 98.57 (n)
  • 97.85 (a)
SCGB2A2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCGB2A2 35
  • 67.78 (n)
  • 53.33 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
SCGB2A2 35
  • 67.38 (n)
  • 56.99 (a)
mouse
(Mus musculus)
Mammalia Gm2617 36
  • 35 (a)
ManyToMany
Scgb2a2 16
Species with no ortholog for SCGB2A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB2A2 Gene

ENSEMBL:
Gene Tree for SCGB2A2 (if available)
TreeFam:
Gene Tree for SCGB2A2 (if available)

Paralogs for SCGB2A2 Gene

Paralogs for SCGB2A2 Gene

Selected SIMAP similar genes for SCGB2A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCGB2A2: view

Variants for SCGB2A2 Gene

Sequence variations from dbSNP and Humsavar for SCGB2A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4963487 -- 62,269,429(+) GAAGC(A/G)TCCTT upstream-variant-2KB
rs4963488 -- 62,271,929(+) AATTG(C/T)CTCAA intron-variant, utr-variant-3-prime
rs7114227 -- 62,272,305(+) aaggg(A/G)gagtc intron-variant, downstream-variant-500B
rs7125138 -- 62,269,397(+) cattg(C/T)gaccg upstream-variant-2KB
rs7126448 -- 62,271,298(+) GGGCA(A/T)GAGAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SCGB2A2 Gene

Variant ID Type Subtype PubMed ID
esv33305 CNV Loss 17666407

Relevant External Links for SCGB2A2 Gene

HapMap Linkage Disequilibrium report
SCGB2A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB2A2 Gene

Disorders for SCGB2A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SCGB2A2 Gene including...

Search for SCGB2A2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SCGB2A2 Gene

(9) Novoseek inferred disease relationships for SCGB2A2 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 67.6 38
breast carcinoma 61.5 7
breast cancer metastatic 59.1 1
adenocarcinoma lung 37.4 2
tumors 31.8 17

Relevant External Links for SCGB2A2

Genetic Association Database (GAD)
SCGB2A2
genes like me logo Genes that share disorders with SCGB2A2: view

No data available for UniProtKB/Swiss-Prot for SCGB2A2 Gene

Publications for SCGB2A2 Gene

  1. Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13. (PMID: 9488047) Watson M.A. … Fleming T. (Oncogene 1998) 2 3 4
  2. Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer. (PMID: 8631025) Watson M.A. … Fleming T.P. (Cancer Res. 1996) 2 3 4
  3. Analysis of the immunohistochemical expression of mammaglobin A in primary breast carcinoma and lymph node metastasis. (PMID: 19690758) Raica M. … MureA9an A. (Rom J Morphol Embryol 2009) 3 23
  4. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SCGB2A2 Gene

Sources for SCGB2A2 Gene

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