SCGB2A2 Gene
protein-coding GIFtS: 51
GCID: GC11P062038
|
|
secretoglobin, family 2A, member 2(Previous name: mammaglobin 1 )
(Previous symbol: MGB1)
| |
Aliases
for SCGB2A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Secretoglobin, Family 2A, Member 21 2 | | Mammaglobin A2 | | MGB11 2 3 5 | | Mammaglobin-13 | | UGB21 2 3 | | Mammaglobin-A1 | | Mammaglobin 11 2 | | Mammaglobin-13 | | MGC719741 | | Secretoglobin Family 2A Member 23 |
Export aliases for SCGB2A2 gene to outside databasesPrevious GC identifers: GC11P064551 GC11P063613 GC11P062288 GC11P061812 GC11P061794 GC11P058366 |
Summaries
for SCGB2A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for SCGB2A2 (Mammaglobin-A)
|
Genomic Views
for SCGB2A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCGB2A2 gene promoter:
MEF-2A Sox5 p53 aMEF-2 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCGB2A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCGB2A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q13SCGB2A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P062038: view genomic region
(about GC identifiers)
Start:
|
62,037,627 bp from pter |
End:
|
62,040,628 bp from pter |
Size:
|
3,002 bases |
Orientation:
|
plus strand |
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Proteins
for SCGB2A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SG2A2_HUMAN, Q13296 (See
protein sequence)Recommended Name: Mammaglobin-A precursor Size: 93 amino acids; 10499 Da
Secondary accessions: A1A522 Q86WH8Alternative splicing: 2 isoforms: Q13296-1 Q13296-2 Explore the universe of human proteins at neXtProt for SCGB2A2: NX_Q13296
SCGB2A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002402.1
ENSEMBL proteins: ENSP00000227918 ENSP00000431997
Human Recombinant Protein Products for SCGB2A2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
SCGB2A2 for ontologies About GeneDecksing
SCGB2A2 Antibody Products:
Assay Products for SCGB2A2: |
Protein
Domains /
Families
for SCGB2A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCGB2A2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13296ProtoNet protein and cluster: Q13296 1 Blocks protein family: IPB003628 Uteroglobin subtype
UniProtKB/Swiss-Prot: SG2A2_HUMAN, Q13296Similarity: Belongs to the secretoglobin family. Lipophilin subfamily |
Function
for SCGB2A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005496 | steroid binding |
IEA | -- |
SCGB2A2 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCGB2A2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SCGB2A2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCGB2A2 |
|
Pathways & Interactions
for SCGB2A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCGB2A2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SCGB2A2 (Q132963 ENSP000002279184) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
SCGB2A2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SCGB2A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SCGB2A2 for compounds About GeneDecksing
 Browse Tocris compounds for SCGB2A2
1 Novoseek chemical compound relationship for SCGB2A2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| estrogen |
23.9 |
10 |
17192791 (3), 14515009 (3) |
Search CenterWatch for drugs/clinical trials and news about SCGB2A2 / SG2A2
|
Transcripts
for SCGB2A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCGB2A2 gene: NM_002411.2 Unigene Cluster for SCGB2A2: Secretoglobin, family 2A, member 2 Hs.46452 [show with all ESTs]Unigene Representative Sequence: BC0672202 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000227918(uc001ntc.3 uc009ynx.3) ENST00000525380
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCGB2A2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCGB2A2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SCGB2A2 (NM_002411) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCGB2A2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCGB2A2 |
Additional cDNA sequence: AY217100.1 BC067220.1 BC128252.1 BC128402.1 U33147.1 3 DOTS entries: DT.109282 DT.97812058 DT.75152339 22 AceView cDNA sequences: AA513632 AI904282 AY217100 AI732533 AI791322 U33147 AI904278 BC067220 AA513640 AI732534 NM_002411 AA513647 AA991451 AI905265 CD000816 BG207094 BG185363 BE694112 CA454060 BQ028215 AW175603 BE927089
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2A2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SCGB2A2
|
Expression
for SCGB2A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCGB2A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SCGB2A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCGB2A2
SOURCE GeneReport for Unigene cluster: Hs.46452
UniProtKB/Swiss-Prot: SG2A2_HUMAN, Q13296Tissue specificity: Mammary gland specific. Over-expressed in breast cancer
SABiosciences Custom PCR Arrays for SCGB2A2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCGB2A2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCGB2A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCGB2A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCGB2A2 |
Orthologs
for SCGB2A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SCGB2A2 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Scgb2a25 |
secretoglobin, family 2A, member 2 |
-- |
|
19 - |
ENSEMBL Gene Tree for SCGB2A2 (if available)
TreeFam Gene Tree for SCGB2A2 (if available) |
Paralogs
for SCGB2A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCGB2A2 gene
- SCGB2A12
1 SIMAP similar gene for SCGB2A2 using alignment to 2 protein entries: SG2A2_HUMAN (see all proteins):SCGB2A1
SCGB2A2 for paralogs About GeneDecksing
|
Genomic Variants
for SCGB2A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCGB2A2 (62037627 - 62040628 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SCGB2A2
1 CNV: 6930 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCGB2A2 |
|
Disorders
/ Diseases
for SCGB2A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCGB2A2 for disorders About GeneDecksing
OMIM gene information: 605562
OMIM disorders: --
6  diseases for SCGB2A2: About MalaCardsallergic rhinitis rhinitis breast cancer breast carcinoma
lung cancer carcinoma
1 disease from the University of Copenhagen DISEASES database for SCGB2A2:Breast cancer 9 Novoseek disease relationships for SCGB2A2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
67.6 |
47 |
17192791 (8), 15096563 (4), 14696125 (3), 18451221 (3) (see all 19) |
| breast carcinoma |
61.5 |
7 |
19217055 (4), 19690758 (1), 12563241 (1), 16538532 (1) |
| breast cancer metastatic |
59.1 |
2 |
15096563 (1) |
| adenocarcinoma lung |
37.4 |
3 |
15096563 (1), 17192791 (1) |
| tumors |
31.8 |
24 |
16603086 (3), 14515009 (3), 17192791 (2), 18451221 (2) (see all 11) |
| primary tumor |
30.9 |
2 |
12019145 (1), 10767368 (1) |
| metastasis |
27.3 |
8 |
15151203 (2), 17192791 (2), 12019145 (1), 16925986 (1) (see all 5) |
| carcinoma |
21 |
4 |
19217055 (2), 15451460 (1) |
| cancer |
20.3 |
5 |
17192791 (2), 16760290 (1), 16603086 (1) |
Export disorders for SCGB2A2 gene to outside databases
|
Publications
for SCGB2A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCGB2A2 gene, integrated from 9 sources (see all 69):
(articles sorted by number of sources associating them with SCGB2A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13. (PubMed id 9488047)1, 2, 3 Watson M.A.... Fleming T. (1998)
- Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer. (PubMed id 8631025)1, 2, 3 Watson M.A. and Fleming T.P. (1996)
- Update of the human secretoglobin (SCGB) gene superfa mily and an example of 'evolutionary bloom' of androgen-binding protein genes w ithin the mouse Scgb gene superfamily. (PubMed id 22155607)1, 3 Jackson B.C....Vasiliou V. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers. (PubMed id 17192791)1, 9 Sasaki E....Yatabe Y. (2007)
- Detection and quantification of mammaglobin in the blood of breast cancer patients: can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. (PubMed id 16760290)1, 9 Gargano G....Russo A. (2006)
- Diagnostic utility of mammaglobin and GCDFP-15 in the identification of metastatic breast carcinoma in fluid specimens. (PubMed id 19217055)1, 9 Yan Z....Chhieng D.C. (2009)
- Expression of mammaglobins A and B in nasal polyps is similar in patients with and without allergic rhinitis. (PubMed id 18416968)1, 9 Chusakul S....Shotelersuk V. (2008)
- Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer. (PubMed id 18451221)1, 9 Ignatiadis M....Mavroudis D. (2008)
- RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes. (PubMed id 15151203)1, 9 Ouellette R.J....Maicas E. (2004)
|
External Searches for SCGB2A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCGB2A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCGB2A2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCGB2A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SCGB2A2 gene:
Search GeneIP for patents involving SCGB2A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCGB2A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | SCGB2A2 Proteins, Antibodies, CLIAs, and ELISAs |
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