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SCGB2A2 Gene

protein-coding   GIFtS: 52
GCID: GC11P062038

Secretoglobin, Family 2A, Member 2

(Previous name: mammaglobin 1)
(Previous symbol: MGB1)
  See SCGB2A2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secretoglobin, Family 2A, Member 21 2     Mammaglobin A1
MGB11 2 3 5     mammaglobin-A2
Mammaglobin 11 2     Mammaglobin-13
UGB22 3     Secretoglobin Family 2A Member 23

External Ids:    HGNC: 70501   Entrez Gene: 42502   Ensembl: ENSG000001104847   OMIM: 6055625   UniProtKB: Q132963   

Export aliases for SCGB2A2 gene to outside databases

Previous GC identifers: GC11P064551 GC11P063613 GC11P062288 GC11P061812 GC11P061794 GC11P058366


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SCGB2A2 Gene:
SCGB2A2 (secretoglobin, family 2A, member 2) is a protein-coding gene. Diseases associated with SCGB2A2 include breast cancer. GO annotations related to this gene include steroid binding. An important paralog of this gene is SCGB2A1.

Gene Wiki entry for SCGB2A2 (Mammaglobin-A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCGB2A2 gene promoter:
         MEF-2A   Sox5   p53   aMEF-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCGB2A2 promoter sequence
   Search Chromatin IP Primers for SCGB2A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCGB2A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q13

SCGB2A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCGB2A2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062038:  view genomic region     (about GC identifiers)

Start:
62,037,627 bp from pter      End:
62,040,628 bp from pter
Size:
3,002 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SG2A2_HUMAN, Q13296 (See protein sequence)
Recommended Name: Mammaglobin-A precursor  
Size: 93 amino acids; 10499 Da
Secondary accessions: A1A522 Q86WH8
Alternative splicing: 2 isoforms:  Q13296-1   Q13296-2   

Explore the universe of human proteins at neXtProt for SCGB2A2: NX_Q13296

Explore proteomics data for SCGB2A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn53, Asn68

  • See SCGB2A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002402.1  
    ENSEMBL proteins: 
     ENSP00000227918   ENSP00000431997  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SCGB: Secretoglobins

    2 InterPro protein domains:
     IPR016126 Secretoglobin
     IPR003627 Mamgb/prostatn

    Graphical View of Domain Structure for InterPro Entry Q13296

    ProtoNet protein and cluster: Q13296

    1 Blocks protein domain: IPB003628 Uteroglobin subtype

    UniProtKB/Swiss-Prot: SG2A2_HUMAN, Q13296
    Similarity: Belongs to the secretoglobin family. Lipophilin subfamily


    Find genes that share domains with SCGB2A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005496steroid binding ----
         
    Find genes that share ontologies with SCGB2A2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SCGB2A2

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    miRTarBase miRNAs that target SCGB2A2:
    hsa-mir-335-5p (MIRT019036)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with SCGB2A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCGB2A2
    Interactions:

        Search GeneGlobe Interaction Network for SCGB2A2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SCGB2A2 (Q132963 ENSP000002279184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCGB1D2O959693, ENSP000002449264I2D: score=1 STRING: ENSP00000244926
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with SCGB2A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SCGB2A2 (SG2A2)

    1 Novoseek inferred chemical compound relationship for SCGB2A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 23.9 10 17192791 (3), 14515009 (3)



    Find genes that share compounds with SCGB2A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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    REFSEQ mRNAs for SCGB2A2 gene: 
    NM_002411.3  

    Unigene Cluster for SCGB2A2:

    Secretoglobin, family 2A, member 2
    Hs.46452  [show with all ESTs]
    Unigene Representative Sequence: BC067220
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227918(uc001ntc.3 uc009ynx.3) ENST00000525380
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    Additional mRNA sequence: 

    AY217100.1 BC067220.1 BC128252.1 BC128402.1 U33147.1 

    3 DOTS entries:

    DT.109282  DT.97812058  DT.75152339 

    22 AceView cDNA sequences:

    AY217100 AA513632 AI904282 AI904278 U33147 NM_002411 AI732534 AI732533 
    AA513640 BC067220 AI791322 AA991451 AA513647 AI905265 CD000816 BG207094 
    BG185363 BE694112 CA454060 BQ028215 AW175603 BE927089 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2A2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
    SP1:                          -               
    SP2:                    -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for SCGB2A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCGB2A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SCGB2A2 Expression
    About this image

    SCGB2A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCGB2A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46452

    UniProtKB/Swiss-Prot: SG2A2_HUMAN, Q13296
    Tissue specificity: Mammary gland specific. Over-expressed in breast cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SCGB2A2 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scgb2a25 secretoglobin, family 2A, member 2   --   19 -


    ENSEMBL Gene Tree for SCGB2A2 (if available)
    TreeFam Gene Tree for SCGB2A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCGB2A2 gene
    SCGB2A12  
    1 SIMAP similar gene for SCGB2A2 using alignment to 2 protein entries:     SG2A2_HUMAN (see all proteins):
    SCGB2A1

    Find genes that share paralogs with SCGB2A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCGB2A2 (see all 153)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729194621,2
    C,F--62035663(+) TCCACG/AGGAAG 1 -- us2k12Minor allele frequency- A:0.10WA NA 238
    rs128009271,2
    C,F,H--62035677(+) AGAACC/TGACTC 1 -- us2k112Minor allele frequency- T:0.13NS EA NA CSA 806
    rs1379611191,2
    C--62035842(+) CTGGGA/CCTACA 1 -- us2k10--------
    rs1424151461,2
    --62035859(+) CACCAC/GCACGC 1 -- us2k10--------
    rs122823461,2
    C,F,A--62035938(+) CTGACT/CTCATG 1 -- us2k17Minor allele frequency- C:0.32NA CSA WA EA 365
    rs343021041,2
    C,F--62035956(+) TACCTC/TGGCCT 1 -- us2k13Minor allele frequency- T:0.50NA CSA 6
    rs1481864781,2
    --62035987(+) GGCATA/GAGCCA 1 -- us2k10--------
    rs599855601,2
    C,F--62036076(+) TAAACG/AAGGGT 1 -- us2k13Minor allele frequency- A:0.12WA CSA 122
    rs1174769161,2
    F--62036235(+) ACTAGA/GCAGTG 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1812303931,2
    --62036272(+) AAATGG/TCATGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCGB2A2 (62037627 - 62040628 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SCGB2A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33305CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605562    OMIM disorders: --

    1 disease for SCGB2A2:    
    About MalaCards
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for SCGB2A2:
    Breast cancer

    Find genes that share disorders with SCGB2A2           About GenesLikeMe

    9 Novoseek inferred disease relationships for SCGB2A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 67.6 47 17192791 (8), 15096563 (4), 14696125 (3), 18451221 (3) (see all 19)
    breast carcinoma 61.5 7 19217055 (4), 19690758 (1), 12563241 (1), 16538532 (1)
    breast cancer metastatic 59.1 2 15096563 (1)
    adenocarcinoma lung 37.4 3 15096563 (1), 17192791 (1)
    tumors 31.8 24 16603086 (3), 14515009 (3), 17192791 (2), 18451221 (2) (see all 11)
    primary tumor 30.9 2 12019145 (1), 10767368 (1)
    metastasis 27.3 8 15151203 (2), 17192791 (2), 12019145 (1), 16925986 (1) (see all 5)
    carcinoma 21 4 19217055 (2), 15451460 (1)
    cancer 20.3 5 17192791 (2), 16760290 (1), 16603086 (1)

    Genetic Association Database (GAD): SCGB2A2

    Export disorders for SCGB2A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCGB2A2 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with SCGB2A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13. (PubMed id 9488047)1, 2, 3 Watson M.A.... Fleming T. (Oncogene 1998)
    2. Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer. (PubMed id 8631025)1, 2, 3 Watson M.A. and Fleming T.P. (Cancer Res. 1996)
    3. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PubMed id 22155607)1, 3 Jackson B.C....Vasiliou V. (Hum. Genomics 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers. (PubMed id 17192791)1, 9 Sasaki E....Yatabe Y. (Mod. Pathol. 2007)
    6. Detection and quantification of mammaglobin in the blood of breast cancer patients: can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. (PubMed id 16760290)1, 9 Gargano G....Russo A. (Ann. Oncol. 2006)
    7. Diagnostic utility of mammaglobin and GCDFP-15 in the identification of metastatic breast carcinoma in fluid specimens. (PubMed id 19217055)1, 9 Yan Z....Chhieng D.C. (Diagn. Cytopathol. 2009)
    8. Expression of mammaglobins A and B in nasal polyps is similar in patients with and without allergic rhinitis. (PubMed id 18416968)1, 9 Chusakul S....Shotelersuk V. (Am J Rhinol 2008)
    9. Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer. (PubMed id 18451221)1, 9 Ignatiadis M....Mavroudis D. (Clin. Cancer Res. 2008)
    10. RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes. (PubMed id 15151203)1, 9 Ouellette R.J....MaA^cas E. (Am. J. Clin. Pathol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4250 HGNC: 7050 AceView: SCGB2A2 Ensembl:ENSG00000110484 euGenes: HUgn4250
    ECgene: SCGB2A2 H-InvDB: SCGB2A2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCGB2A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SCGB2A2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCGB2A2 gene:
    Search GeneIP for patents involving SCGB2A2

    GeneCards and IP:
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