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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCGB2A2 Gene

protein-coding   GIFtS: 52
GCID: GC11P062038

Secretoglobin, Family 2A, Member 2

(Previous name: mammaglobin 1)
(Previous symbol: MGB1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Secretoglobin, Family 2A, Member 21 2     mammaglobin-12
MGB11 2 3 5     mammaglobin-A2
Mammaglobin 11 2     Mammaglobin-13
Mammaglobin A1 2     Secretoglobin Family 2A Member 23
UGB22 3     

External Ids:    HGNC: 70501   Entrez Gene: 42502   Ensembl: ENSG000001104847   OMIM: 6055625   UniProtKB: Q132963   

Export aliases for SCGB2A2 gene to outside databases

Previous GC identifers: GC11P064551 GC11P063613 GC11P062288 GC11P061812 GC11P061794 GC11P058366


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SCGB2A2 Gene: 
SCGB2A2 (secretoglobin, family 2A, member 2) is a protein-coding gene. Diseases associated with SCGB2A2 include allergic rhinitis, and rhinitis. GO annotations related to this gene include steroid binding and molecular_function. An important paralog of this gene is SCGB2A1.

Gene Wiki entry for SCGB2A2 (Mammaglobin-A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCGB2A2 gene promoter:
         MEF-2A   Sox5   p53   aMEF-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCGB2A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCGB2A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCGB2A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q13

SCGB2A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCGB2A2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062038:  view genomic region     (about GC identifiers)

Start:
62,037,627 bp from pter      End:
62,040,628 bp from pter
Size:
3,002 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SG2A2_HUMAN, Q13296 (See protein sequence)
Recommended Name: Mammaglobin-A precursor  
Size: 93 amino acids; 10499 Da
Secondary accessions: A1A522 Q86WH8
Alternative splicing: 2 isoforms:  Q13296-1   Q13296-2   

Explore the universe of human proteins at neXtProt for SCGB2A2: NX_Q13296

Explore proteomics data for SCGB2A2 at MOPED 

SCGB2A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SCGB2A2 Protein Expression

REFSEQ proteins: NP_002402.1  
ENSEMBL proteins: 
 ENSP00000227918   ENSP00000431997  

Human Recombinant Protein Products for SCGB2A2: 
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Cloud-Clone Corp. Proteins for SCGB2A2 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--

SCGB2A2 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for SCGB2A2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SCGB: Secretoglobins

4 InterPro protein domains:
 IPR016126 Secretoglobin
 IPR003627 Mamgb/prostatn
 IPR006038 Uteroglobin-like_superfam
 IPR006039 Uteroglobin-like_fam

Graphical View of Domain Structure for InterPro Entry Q13296

ProtoNet protein and cluster: Q13296

1 Blocks protein domain: IPB003628 Uteroglobin subtype

UniProtKB/Swiss-Prot: SG2A2_HUMAN, Q13296
Similarity: Belongs to the secretoglobin family. Lipophilin subfamily


SCGB2A2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0005496steroid binding IEA--
     
SCGB2A2 for ontologies           About GeneDecksing


Animal Models:
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miRNA
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SwitchGear 3'UTR luciferase reporter plasmidSCGB2A2 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCGB2A2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCGB2A2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SCGB2A2 (Q132963 ENSP000002279184) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SCGB1D2O959693, ENSP000002449264I2D: score=1 STRING: ENSP00000244926
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

SCGB2A2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SCGB2A2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SCGB2A2 (SG2A2)

1 Novoseek inferred chemical compound relationship for SCGB2A2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen 23.9 10 17192791 (3), 14515009 (3)

Search CenterWatch for drugs/clinical trials and news about SCGB2A2 / SG2A2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCGB2A2 gene: 
NM_002411.2  

Unigene Cluster for SCGB2A2:

Secretoglobin, family 2A, member 2
Hs.46452  [show with all ESTs]
Unigene Representative Sequence: BC067220
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000227918(uc001ntc.3 uc009ynx.3) ENST00000525380
miRNA
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hsa-miR-3065-5p hsa-miR-1305 hsa-miR-421
SwitchGear 3'UTR luciferase reporter plasmidSCGB2A2 3' UTR sequence
Inhib. RNA
Products:
     
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Additional mRNA sequence: 

AY217100.1 BC067220.1 BC128252.1 BC128402.1 U33147.1 

3 DOTS entries:

DT.109282  DT.97812058  DT.75152339 

22 AceView cDNA sequences:

AY217100 AA513632 AI904282 AI791322 BC067220 AI904278 NM_002411 AI732534 
AA513640 U33147 AI732533 AA991451 AA513647 AI905265 CD000816 BG207094 
BG185363 CA454060 BE694112 BQ028215 AW175603 BE927089 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2A2    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
SP1:                          -               
SP2:                    -     -               
SP3:                                          


ECgene alternative splicing isoforms for SCGB2A2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCGB2A2 expression in normal human tissues (normalized intensities)      SCGB2A2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SCGB2A2 Expression
About this image


SCGB2A2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Breast (NULL)    fully expand to see all 3 entries
         breast ; glandular cells   
         MAMMARY GLAND   
 
 Uterus (Reproductive System)    fully expand to see all 2 entries
         uterus, pre-menopause ; glandular cells   
 
 Epithelium
         breast epithelium   
 
 Brain (Nervous System)
         Cerebral Cortex

 -- (Integumentary System)
         Skin   

See SCGB2A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCGB2A2

SOURCE GeneReport for Unigene cluster: Hs.46452

UniProtKB/Swiss-Prot: SG2A2_HUMAN, Q13296
Tissue specificity: Mammary gland specific. Over-expressed in breast cancer

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCGB2A2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for SCGB2A2 gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Scgb2a25 secretoglobin, family 2A, member 2   --   19 -


ENSEMBL Gene Tree for SCGB2A2 (if available)
TreeFam Gene Tree for SCGB2A2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SCGB2A2 gene
SCGB2A12  
1 SIMAP similar gene for SCGB2A2 using alignment to 2 protein entries:     SG2A2_HUMAN (see all proteins):
SCGB2A1

SCGB2A2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/153 SNPs in SCGB2A2 are shown (see all 153)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs729194621,2
C,F--62035663(+) TCCACG/AGGAAG 1 -- us2k12Minor allele frequency- A:0.10WA NA 238
rs128009271,2
C,F,H--62035677(+) AGAACC/TGACTC 1 -- us2k112Minor allele frequency- T:0.13NS EA NA CSA 806
rs1379611191,2
C--62035842(+) CTGGGA/CCTACA 1 -- us2k10--------
rs1424151461,2
--62035859(+) CACCAC/GCACGC 1 -- us2k10--------
rs122823461,2
C,F,A--62035938(+) CTGACT/CTCATG 1 -- us2k17Minor allele frequency- C:0.32NA CSA WA EA 365
rs343021041,2
C,F--62035956(+) TACCTC/TGGCCT 1 -- us2k13Minor allele frequency- T:0.50NA CSA 6
rs1481864781,2
--62035987(+) GGCATA/GAGCCA 1 -- us2k10--------
rs599855601,2
C,F--62036076(+) TAAACG/AAGGGT 1 -- us2k13Minor allele frequency- A:0.12WA CSA 122
rs1174769161,2
F--62036235(+) ACTAGA/GCAGTG 1 -- us2k11Minor allele frequency- G:0.01NA 120
rs1812303931,2
--62036272(+) AAATGG/TCATGG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SCGB2A2 (62037627 - 62040628 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for SCGB2A2:    About this table     
Variant IDTypeSubtypePubMed ID
esv33305CNV Loss17666407

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing SCGB2A2
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605562    OMIM disorders: --

5 diseases for SCGB2A2:    About MalaCards
allergic rhinitis    rhinitis    breast cancer    lung cancer
adenocarcinoma

1 disease from the University of Copenhagen DISEASES database for SCGB2A2:
Breast cancer

SCGB2A2 for disorders           About GeneDecksing

9 Novoseek inferred disease relationships for SCGB2A2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer 67.6 47 17192791 (8), 15096563 (4), 14696125 (3), 18451221 (3) (see all 19)
breast carcinoma 61.5 7 19217055 (4), 19690758 (1), 12563241 (1), 16538532 (1)
breast cancer metastatic 59.1 2 15096563 (1)
adenocarcinoma lung 37.4 3 15096563 (1), 17192791 (1)
tumors 31.8 24 16603086 (3), 14515009 (3), 17192791 (2), 18451221 (2) (see all 11)
primary tumor 30.9 2 12019145 (1), 10767368 (1)
metastasis 27.3 8 15151203 (2), 17192791 (2), 12019145 (1), 16925986 (1) (see all 5)
carcinoma 21 4 19217055 (2), 15451460 (1)
cancer 20.3 5 17192791 (2), 16760290 (1), 16603086 (1)

Genetic Association Database (GAD): SCGB2A2

Export disorders for SCGB2A2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SCGB2A2 gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with SCGB2A2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13. (PubMed id 9488047)1, 2, 3 Watson M.A.... Fleming T. (1998)
  2. Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer. (PubMed id 8631025)1, 2, 3 Watson M.A. and Fleming T.P. (1996)
  3. Update of the human secretoglobin (SCGB) gene superfa mily and an example of 'evolutionary bloom' of androgen-binding protein genes w ithin the mouse Scgb gene superfamily. (PubMed id 22155607)1, 3 Jackson B.C....Vasiliou V. (2011)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers. (PubMed id 17192791)1, 9 Sasaki E....Yatabe Y. (2007)
  6. Detection and quantification of mammaglobin in the blood of breast cancer patients: can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. (PubMed id 16760290)1, 9 Gargano G....Russo A. (2006)
  7. Diagnostic utility of mammaglobin and GCDFP-15 in the identification of metastatic breast carcinoma in fluid specimens. (PubMed id 19217055)1, 9 Yan Z....Chhieng D.C. (2009)
  8. Expression of mammaglobins A and B in nasal polyps is similar in patients with and without allergic rhinitis. (PubMed id 18416968)1, 9 Chusakul S....Shotelersuk V. (2008)
  9. Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer. (PubMed id 18451221)1, 9 Ignatiadis M....Mavroudis D. (2008)
  10. RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes. (PubMed id 15151203)1, 9 Ouellette R.J....Maicas E. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
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OMIM
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4250 HGNC: 7050 AceView: SCGB2A2 Ensembl:ENSG00000110484 euGenes: HUgn4250
ECgene: SCGB2A2 H-InvDB: SCGB2A2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SCGB2A2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SCGB2A2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SCGB2A2 gene:
Search GeneIP for patents involving SCGB2A2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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