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SCGB2A1 Gene

protein-coding   GIFtS: 49
GCID: GC11P061976

Secretoglobin, Family 2A, Member 1

(Previous name: mammaglobin 2)
(Previous symbol: MGB2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secretoglobin, Family 2A, Member 11 2     lipophilin-C2
MGB21 2 3 5     mammaglobin-22
Mammaglobin 21 2     mammaglobin-B2
lacryglobin1 2     LIPHC3
Lipophilin C1 2     Lacryglobin3
Mammaglobin B1 2     Lipophilin-C3
UGB32 3     Mammaglobin-23
LPNC2 5     Secretoglobin Family 2A Member 13
LPHC2     

External Ids:    HGNC: 70511   Entrez Gene: 42462   Ensembl: ENSG000001249397   OMIM: 6043985   UniProtKB: O755563   

Export aliases for SCGB2A1 gene to outside databases

Previous GC identifers: GC11P064489 GC11P063552 GC11P062227 GC11P061751 GC11P061732 GC11P058304


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SCGB2A1 Gene:
SCGB2A1 (secretoglobin, family 2A, member 1) is a protein-coding gene. Diseases associated with SCGB2A1 include ovarian cancer, and allergic rhinitis. GO annotations related to this gene include androgen binding. An important paralog of this gene is SCGB2A2.

UniProtKB/Swiss-Prot: SG2A1_HUMAN, O75556
Function: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for
prostate cancer. May be under transcriptional regulation of steroid hormones

Gene Wiki entry for SCGB2A1 (Mammaglobin-B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCGB2A1 gene promoter:
         TBP   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCGB2A1 promoter sequence
   Search Chromatin IP Primers for SCGB2A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCGB2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q13

SCGB2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCGB2A1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P061976:  view genomic region     (about GC identifiers)

Start:
61,976,140 bp from pter      End:
61,981,411 bp from pter
Size:
5,272 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SG2A1_HUMAN, O75556 (See protein sequence)
Recommended Name: Mammaglobin-B precursor  
Size: 95 amino acids; 10884 Da
Subunit: Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head
Mass spectrometry: Mass=8854.94; Method=Electrospray; Range=19-95; Source=PubMed:9720917;

Explore the universe of human proteins at neXtProt for SCGB2A1: NX_O75556

Explore proteomics data for SCGB2A1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn68

  • See SCGB2A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002398.1  
    ENSEMBL proteins: 
     ENSP00000244930  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SCGB: Secretoglobins

    2 InterPro protein domains:
     IPR016126 Secretoglobin
     IPR003627 Mamgb/prostatn

    Graphical View of Domain Structure for InterPro Entry O75556

    ProtoNet protein and cluster: O75556

    1 Blocks protein domain: IPB003628 Uteroglobin subtype

    UniProtKB/Swiss-Prot: SG2A1_HUMAN, O75556
    Similarity: Belongs to the secretoglobin family. Lipophilin subfamily


    SCGB2A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SG2A1_HUMAN, O75556
    Function: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for
    prostate cancer. May be under transcriptional regulation of steroid hormones

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005496steroid binding IEA--
    GO:0005497androgen binding ----
    GO:0046982protein heterodimerization activity IDA9720917
         
    SCGB2A1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SCGB2A1:
     Cell cycle / mitosis defect  Cell division defect  Decreased viability of wild-ty  Increased S DNA content 
     Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCGB2A1
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    2 qRT-PCR Assays for microRNAs that regulate SCGB2A1:
    hsa-miR-203 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSCGB2A1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ----
    GO:0005615extracellular space IDA16395610

    SCGB2A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCGB2A1
    Interactions:

        Search GeneGlobe Interaction Network for SCGB2A1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SCGB2A1 (O755563 ENSP000002449304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCGB1D1O959683, ENSP000003030704I2D: score=1 STRING: ENSP00000303070
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0030521androgen receptor signaling pathway IDA16020486

    SCGB2A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCGB2A1 (SG2A1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SCGB2A1 gene: 
    NM_002407.2  

    Unigene Cluster for SCGB2A1:

    Secretoglobin, family 2A, member 1
    Hs.97644  [show with all ESTs]
    Unigene Representative Sequence: CB957406
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244930(uc001nta.2)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SCGB2A1:
    hsa-miR-203 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSCGB2A1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SCGB2A1
      QuantiFast Probe-based Assays in human, mouse, rat SCGB2A1

    Additional mRNA sequence: 

    AF071219.1 AJ224173.1 BC062218.1 

    1 DOTS entry:

    DT.211005 

    Selected AceView cDNA sequences (see all 59):

    AA297482 CK903449 CK430913 CD723385 CK429974 BI964837 CK429914 AA297405 
    CD723615 CK430493 AA398560 CD723581 CK429493 AA297456 CD724242 CD722232 
    CD721930 CD723152 AW207696 CK430087 CK903448 CK429668 CK429302 AA393164 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCGB2A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCGGCCC
    SCGB2A1 Expression
    About this image

    SCGB2A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCGB2A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97644

    UniProtKB/Swiss-Prot: SG2A1_HUMAN, O75556
    Tissue specificity: Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus,
    breast and ovary) and salivary gland

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCGB2A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for SCGB2A1 (if available)
    TreeFam Gene Tree for SCGB2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCGB2A1 gene
    SCGB2A22  
    1 SIMAP similar gene for SCGB2A1 using alignment to 1 protein entry:     SG2A1_HUMAN:
    SCGB2A2

    SCGB2A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCGB2A1 (see all 253)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913578581,2
    --61974182(+) AGAGCA/GTCGGC 1 -- us2k10--------
    rs1124746041,2
    C,F--61974249(+) ATCACG/AAGGTC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs665503321,2
    C--61974313(+) ATACA-/AAAT/ 
    AAATAAAT
    AAATA
    1 -- us2k10--------
    rs587386021,2
    C--61974316(+) ATAAA-/TAAA  
            
    AATTA
    1 -- us2k11Minor allele frequency- TAAA:0.00NA 2
    rs714564011,2
    C--61974351(+) ATAAA-/TAAA  
            
    TAAAT
    1 -- us2k11Minor allele frequency- TAAA:0.50NA 2
    rs1883981441,2
    --61974363(+) AAAATC/TAGCTG 1 -- us2k10--------
    rs1439082851,2
    --61974434(+) TGAACC/TCGGGA 1 -- us2k10--------
    rs1919259691,2
    --61974436(+) AACCCA/GGGAAG 1 -- us2k10--------
    rs25137461,2
    C--61974483(-) ccaggC/Ttggag 1 -- us2k10--------
    rs25113591,2
    C--61974484(+) tccaaA/Cctggg 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCGB2A1 (61976140 - 61981411 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SCGB2A1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCGB2A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SCGB2A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604398    OMIM disorders: --

    11 diseases for SCGB2A1:    About MalaCards
    ovarian cancer    allergic rhinitis    rhinitis    pituitary adenoma
    adenoma    prostate cancer    breast cancer    prostatitis
    lung cancer    hiv-1    adenocarcinoma


    SCGB2A1 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for SCGB2A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 43.2 13 16357022 (2), 15151203 (2), 10674878 (1), 9806831 (1) (see all 8)
    ovarian cancer 41.3 7 17343903 (3), 14760385 (1), 18021217 (1)
    primary tumor 41 2 16357022 (1), 10767368 (1)
    ovarian carcinoma 29.2 2 17343903 (2)
    metastasis 23.6 4 15151203 (2), 17343903 (1)
    tumors 14.9 7 18021217 (2), 19635143 (2), 17343903 (1), 16120813 (1)
    adenocarcinoma 13.6 1 10755390 (1)
    carcinoma 12.2 5 10873083 (4), 9720917 (1)
    cancer 6.45 7 10755390 (2), 11446459 (2), 19635143 (1)
    prostate cancer 0 1 11446459 (1)


    Export disorders for SCGB2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCGB2A1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with SCGB2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of mammaglobin B, a novel member of the uteroglobin gene family. (PubMed id 9806831)1, 2, 3, 9 Becker R.M....Fleming T.P. (Genomics 1998)
    2. Lipophilins: human peptides homologous to rat prostatein. (PubMed id 10066439)1, 2, 9 Zhao C.... Lehrer R.I. (Biochem. Biophys. Res. Commun. 1999)
    3. Lipophilin, a novel heterodimeric protein of human tears. (PubMed id 9720917)1, 2, 9 Lehrer R.I....Glasgow B.J. (FEBS Lett. 1998)
    4. Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value. (PubMed id 9504814)1, 2, 9 Molloy M.P.... Walsh B.J. (Electrophoresis 1997)
    5. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PubMed id 22155607)1, 3 Jackson B.C....Vasiliou V. (Hum. Genomics 2011)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence. (PubMed id 19635143)1, 9 Tassi R.A....Santin A.D. (BMC Cancer 2009)
    8. Mammaglobin B expression in human endometrial cancer. (PubMed id 18021217)1, 9 Tassi R.A....Santin A.D. (Int. J. Gynecol. Cancer 2008)
    9. RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes. (PubMed id 15151203)1, 9 Ouellette R.J....MaA^cas E. (Am. J. Clin. Pathol. 2004)
    10. Lacryglobin in human tears, a potential marker for cancer. (PubMed id 11446459)1, 9 Evans V....Willcox M.D. (amp 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4246 HGNC: 7051 AceView: SCGB2A1 Ensembl:ENSG00000124939 euGenes: HUgn4246
    ECgene: SCGB2A1 H-InvDB: SCGB2A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCGB2A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SCGB2A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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