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Aliases for SCGB2A1 Gene

Aliases for SCGB2A1 Gene

  • Secretoglobin Family 2A Member 1 2 3 4 5
  • Lacryglobin 2 3 4
  • Mammaglobin-2 3 4
  • Lipophilin C 2 3
  • MGB2 3 4
  • UGB3 3 4
  • Mammaglobin B 2
  • Mammaglobin 2 2
  • Mammaglobin-B 3
  • Lipophilin-C 4
  • LIPHC 4
  • LPHC 3
  • LPNC 3

External Ids for SCGB2A1 Gene

Previous HGNC Symbols for SCGB2A1 Gene

  • MGB2

Previous GeneCards Identifiers for SCGB2A1 Gene

  • GC11P064489
  • GC11P063552
  • GC11P061751
  • GC11P061732
  • GC11P061976
  • GC11P058304

Summaries for SCGB2A1 Gene

GeneCards Summary for SCGB2A1 Gene

SCGB2A1 (Secretoglobin Family 2A Member 1) is a Protein Coding gene. Diseases associated with SCGB2A1 include Hypotrichosis 13 and Ovarian Cancer. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is SCGB2A2.

UniProtKB/Swiss-Prot for SCGB2A1 Gene

  • May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Gene Wiki entry for SCGB2A1 Gene

Additional gene information for SCGB2A1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB2A1 Gene

Genomics for SCGB2A1 Gene

GeneHancer (GH) Regulatory Elements for SCGB2A1 Gene

Promoters and enhancers for SCGB2A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I062208 Promoter 0.8 EPDnew 550.8 0.0 -14 0.1 CTCF ZSCAN21 ZNF512 PRDM10 SCGB2A1 SCGB1D1
GH11I062394 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +190.2 190196 8.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF143 FOS NXF1 CPSF7 CSKMT ASRGL1 GANAB SNHG1 EML3 RN7SL23P INTS5 STX5
GH11I062311 Enhancer 1 Ensembl ENCODE 4.9 +102.8 102840 1 RB1 KLF17 SIN3A ZNF2 IRF4 ZNF48 RAD21 RARA GLIS2 ARID2 ASRGL1 SCGB2A1 SCGB1D4 NPM1P35
GH11I062270 Promoter 0.6 EPDnew 4.7 +61.5 61471 0.1 CTCF SCGB2A2 SCGB2A1 SCGB1D4
GH11I062410 Enhancer 0.4 dbSUPER 4.5 +203.0 202965 2.3 ESRRA PRDM10 FOS INCENP ASRGL1 SCGB2A1 SCGB1A1 LOC102723765
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SCGB2A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCGB2A1 gene promoter:

Genomic Locations for SCGB2A1 Gene

Genomic Locations for SCGB2A1 Gene
chr11:62,208,668-62,213,939
(GRCh38/hg38)
Size:
5,272 bases
Orientation:
Plus strand
chr11:61,976,140-61,981,411
(GRCh37/hg19)

Genomic View for SCGB2A1 Gene

Genes around SCGB2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB2A1 Gene

Proteins for SCGB2A1 Gene

  • Protein details for SCGB2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75556-SG2A1_HUMAN
    Recommended name:
    Mammaglobin-B
    Protein Accession:
    O75556

    Protein attributes for SCGB2A1 Gene

    Size:
    95 amino acids
    Molecular mass:
    10884 Da
    Quaternary structure:
    • Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head.

neXtProt entry for SCGB2A1 Gene

Post-translational modifications for SCGB2A1 Gene

Other Protein References for SCGB2A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB2A1 Gene

Domains & Families for SCGB2A1 Gene

Gene Families for SCGB2A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for SCGB2A1 Gene

Suggested Antigen Peptide Sequences for SCGB2A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75556

UniProtKB/Swiss-Prot:

SG2A1_HUMAN :
  • Belongs to the secretoglobin family. Lipophilin subfamily.
Family:
  • Belongs to the secretoglobin family. Lipophilin subfamily.
genes like me logo Genes that share domains with SCGB2A1: view

Function for SCGB2A1 Gene

Molecular function for SCGB2A1 Gene

UniProtKB/Swiss-Prot Function:
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Phenotypes From GWAS Catalog for SCGB2A1 Gene

Gene Ontology (GO) - Molecular Function for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046982 protein heterodimerization activity IDA 9720917
genes like me logo Genes that share ontologies with SCGB2A1: view
genes like me logo Genes that share phenotypes with SCGB2A1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB2A1 Gene

Localization for SCGB2A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB2A1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9720917
genes like me logo Genes that share ontologies with SCGB2A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SCGB2A1 Gene

Pathways & Interactions for SCGB2A1 Gene

SuperPathways for SCGB2A1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030521 androgen receptor signaling pathway IDA 16020486
genes like me logo Genes that share ontologies with SCGB2A1: view

No data available for Pathways by source and SIGNOR curated interactions for SCGB2A1 Gene

Drugs & Compounds for SCGB2A1 Gene

No Compound Related Data Available

Transcripts for SCGB2A1 Gene

mRNA/cDNA for SCGB2A1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB2A1 Gene

Secretoglobin, family 2A, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2A1 Gene

No ASD Table

Relevant External Links for SCGB2A1 Gene

GeneLoc Exon Structure for
SCGB2A1
ECgene alternative splicing isoforms for
SCGB2A1

Expression for SCGB2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCGB2A1 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB2A1 Gene

This gene is overexpressed in Cervix - Endocervix (x27.0), Uterus (x7.7), and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for SCGB2A1 Gene

This gene is overexpressed in Cervix (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCGB2A1 Gene



Protein tissue co-expression partners for SCGB2A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCGB2A1 Gene:

SCGB2A1

SOURCE GeneReport for Unigene cluster for SCGB2A1 Gene:

Hs.97644

mRNA Expression by UniProt/SwissProt for SCGB2A1 Gene:

O75556-SG2A1_HUMAN
Tissue specificity: Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.

Evidence on tissue expression from TISSUES for SCGB2A1 Gene

  • Thyroid gland(4.1)
genes like me logo Genes that share expression patterns with SCGB2A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB2A1 Gene

Orthologs for SCGB2A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB2A1 33 34
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia SCGB2A2 34
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 46 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Scgb2a2 34
  • 34 (a)
OneToMany
Species where no ortholog for SCGB2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB2A1 Gene

ENSEMBL:
Gene Tree for SCGB2A1 (if available)
TreeFam:
Gene Tree for SCGB2A1 (if available)

Paralogs for SCGB2A1 Gene

Paralogs for SCGB2A1 Gene

(1) SIMAP similar genes for SCGB2A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCGB2A1: view

Variants for SCGB2A1 Gene

Sequence variations from dbSNP and Humsavar for SCGB2A1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000488429 -- 62,211,017(+) G/A intron_variant
rs1000505003 -- 62,212,405(+) C/T intron_variant
rs1000700389 -- 62,209,927(+) G/A intron_variant
rs1000776193 -- 62,211,258(+) G/A intron_variant
rs1001003847 -- 62,212,677(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SCGB2A1 Gene

Variant ID Type Subtype PubMed ID
nsv1035554 CNV gain 25217958
nsv1113397 CNV deletion 24896259

Variation tolerance for SCGB2A1 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCGB2A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB2A1 Gene

Disorders for SCGB2A1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SCGB2A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypotrichosis 13
  • hypt13
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SCGB2A1

genes like me logo Genes that share disorders with SCGB2A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB2A1 Gene

Publications for SCGB2A1 Gene

  1. Identification of mammaglobin B, a novel member of the uteroglobin gene family. (PMID: 9806831) Becker RM … Fleming TP (Genomics 1998) 2 3 4 22 58
  2. Lipophilins: human peptides homologous to rat prostatein. (PMID: 10066439) Zhao C … Lehrer RI (Biochemical and biophysical research communications 1999) 3 4 22 58
  3. Lipophilin, a novel heterodimeric protein of human tears. (PMID: 9720917) Lehrer RI … Glasgow BJ (FEBS letters 1998) 3 4 22 58
  4. Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value. (PMID: 9504814) Molloy MP … Walsh BJ (Electrophoresis 1997) 3 4 22 58
  5. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson BC … Vasiliou V (Human genomics 2011) 2 3 58

Products for SCGB2A1 Gene

Sources for SCGB2A1 Gene

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