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Aliases for SCGB1D4 Gene

Aliases for SCGB1D4 Gene

  • Secretoglobin, Family 1D, Member 4 2 3
  • IIS 3 4 6
  • IFN-Gamma-Inducible Secretoglobin 3 4
  • Secretoglobin Family 1D Member 4 3
  • IFN-Gamma Inducible SCGB (IIS) 3

External Ids for SCGB1D4 Gene

Summaries for SCGB1D4 Gene

GeneCards Summary for SCGB1D4 Gene

SCGB1D4 (Secretoglobin, Family 1D, Member 4) is a Protein Coding gene. Diseases associated with SCGB1D4 include common cold. An important paralog of this gene is SCGB1D1.

UniProtKB/Swiss-Prot for SCGB1D4 Gene

  • Seems to be involved in the regulation of chemotactic cell migration and invasion

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1D4 Gene

Genomics for SCGB1D4 Gene

Genomic Location for SCGB1D4 Gene

Start:
62,296,277 bp from pter
End:
62,299,064 bp from pter
Size:
2,788 bases
Orientation:
Minus strand

Genomic View for SCGB1D4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCGB1D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB1D4 Gene

Regulatory Elements for SCGB1D4 Gene

Transcription factor binding sites by QIAGEN in the SCGB1D4 gene promoter:

Proteins for SCGB1D4 Gene

  • Protein details for SCGB1D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XE38-SG1D4_HUMAN
    Recommended name:
    Secretoglobin family 1D member 4
    Protein Accession:
    Q6XE38
    Secondary Accessions:
    • A1L4Q8

    Protein attributes for SCGB1D4 Gene

    Size:
    83 amino acids
    Molecular mass:
    9201 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCGB1D4 Gene

Proteomics data for SCGB1D4 Gene at MOPED

Post-translational modifications for SCGB1D4 Gene

No Post-translational modifications

Other Protein References for SCGB1D4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB1D4 Gene

Domains for SCGB1D4 Gene

Gene Families for SCGB1D4 Gene

HGNC:
  • SCGB :Secretoglobins

Protein Domains for SCGB1D4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SG1D4_HUMAN
Family:
  • Belongs to the secretoglobin family. Lipophilin subfamily.:
    • Q6XE38
genes like me logo Genes that share domains with SCGB1D4: view

Function for SCGB1D4 Gene

Molecular function for SCGB1D4 Gene

UniProtKB/Swiss-Prot Function: Seems to be involved in the regulation of chemotactic cell migration and invasion
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma.

Phenotypes for SCGB1D4 Gene

GenomeRNAi human phenotypes for SCGB1D4:
genes like me logo Genes that share phenotypes with SCGB1D4: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SCGB1D4 Gene

Localization for SCGB1D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1D4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB1D4 Gene COMPARTMENTS Subcellular localization image for SCGB1D4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SCGB1D4: view

Pathways for SCGB1D4 Gene

SuperPathways for SCGB1D4 Gene

No Data Available

Interacting Proteins for SCGB1D4 Gene

Gene Ontology (GO) - Biological Process for SCGB1D4 Gene

None

No data available for Pathways by source for SCGB1D4 Gene

Transcripts for SCGB1D4 Gene

mRNA/cDNA for SCGB1D4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB1D4 Gene

Secretoglobin, family 1D, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1D4 Gene

No ASD Table

Relevant External Links for SCGB1D4 Gene

GeneLoc Exon Structure for
SCGB1D4
ECgene alternative splicing isoforms for
SCGB1D4

Expression for SCGB1D4 Gene

mRNA expression in normal human tissues for SCGB1D4 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB1D4 Gene

This gene is overexpressed in Cervix - Endocervix (22.6), Fallopian Tube (17.0), and Uterus (9.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SCGB1D4 Gene

SOURCE GeneReport for Unigene cluster for SCGB1D4 Gene Hs.473247

mRNA Expression by UniProt/SwissProt for SCGB1D4 Gene

Q6XE38-SG1D4_HUMAN
Tissue specificity: Expressed in all tissues; the highest level of expression is detectable in lymph nodes, tonsil, cultured lymphoblasts and ovary.
genes like me logo Genes that share expressions with SCGB1D4: view

Orthologs for SCGB1D4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1D4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB1D4 36
  • 96.2 (n)
  • 94.94 (a)
SCGB1D4 37
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCGB1D 37
  • 42 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 41 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
Species with no ortholog for SCGB1D4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB1D4 Gene

ENSEMBL:
Gene Tree for SCGB1D4 (if available)
TreeFam:
Gene Tree for SCGB1D4 (if available)

Paralogs for SCGB1D4 Gene

Paralogs for SCGB1D4 Gene

Selected SIMAP similar genes for SCGB1D4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SCGB1D4 Gene

genes like me logo Genes that share paralogs with SCGB1D4: view

Variants for SCGB1D4 Gene

Sequence variations from dbSNP and Humsavar for SCGB1D4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs954236 -- 62,296,922(+) CCTCA(G/T)GACAA intron-variant
rs954237 -- 62,297,243(+) TCCCA(C/T)AGTGA intron-variant
rs1009052 -- 62,299,679(+) CCAAA(A/C)CTGAA upstream-variant-2KB
rs1406382 -- 62,300,982(-) CAAGC(C/T)TGAGT upstream-variant-2KB
rs1406383 -- 62,300,912(-) GAGGC(C/T)TCAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SCGB1D4 Gene

Variant ID Type Subtype PubMed ID
esv33305 CNV Loss 17666407

Relevant External Links for SCGB1D4 Gene

HapMap Linkage Disequilibrium report
SCGB1D4

Disorders for SCGB1D4 Gene

(1) MalaCards Diseases for SCGB1D4 Gene

Search for SCGB1D4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SCGB1D4 Gene

genes like me logo Genes that share disorders with SCGB1D4: view

No data available for UniProtKB/Swiss-Prot for SCGB1D4 Gene

Publications for SCGB1D4 Gene

  1. IFN-gamma stimulates the expression of a novel secretoglobin that regulates chemotactic cell migration and invasion. (PMID: 15034037) Choi M.S. … Mukherjee A.B. (J. Immunol. 2004) 2 3 4 23
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 2 3 4
  3. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 3
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SCGB1D4 Gene

Sources for SCGB1D4 Gene

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