SCGB1D2 Gene
protein-coding GIFtS: 46
GCID: GC11P062009
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secretoglobin, family 1D, member 2
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Aliases
for SCGB1D2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| Secretoglobin, Family 1D, Member 21 2 | | Prostatein-Like Lipophilin B2 | | LIPB1 2 | | Secretoglobin Family 1D Member 22 | | LPHB1 2 | | LIPHB3 | | LPNB2 3 | | Lipophilin-B3 | | Lipophilin-B3 | | |
Export aliases for SCGB1D2 gene to outside databasesPrevious GC identifers: GC11P064523 GC11P063585 GC11P062260 GC11P061785 GC11P061752 GC11P061766 GC11P058338 |
Summaries
for SCGB1D2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SCGB1D2:
The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and isan ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin geneproducts are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that humanlipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroidhormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, achemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10,this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: SG1D2_HUMAN, O95969Function: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostatecancer. May be under transcriptional regulation of steroid hormones
Gene Wiki entry for SCGB1D2
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Genomic Views
for SCGB1D2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCGB1D2 gene promoter:
p53 NRSF form 1 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCGB1D2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCGB1D2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q13SCGB1D2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P062009: view genomic region
(about GC identifiers)
Start:
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62,009,682 bp from pter |
End:
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62,012,280 bp from pter |
Size:
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2,599 bases |
Orientation:
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plus strand |
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Proteins
for SCGB1D2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SG1D2_HUMAN, O95969 (See
protein sequence)Recommended Name: Secretoglobin family 1D member 2 precursor Size: 90 amino acids; 9925 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q2M3N9Explore the universe of human proteins at neXtProt for SCGB1D2: NX_O95969
SCGB1D2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006542.1
ENSEMBL proteins: ENSP00000244926
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
SCGB1D2 for ontologies About GeneDecksing
SCGB1D2 Antibody Products:
Assay Products for SCGB1D2: |
Protein
Domains /
Families
for SCGB1D2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCGB1D2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95969ProtoNet protein and cluster: O95969 UniProtKB/Swiss-Prot: SG1D2_HUMAN, O95969Similarity: Belongs to the secretoglobin family. Lipophilin subfamily |
Function
for SCGB1D2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SG1D2_HUMAN, O95969Function: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostatecancer. May be under transcriptional regulation of steroid hormones
Clone
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Pathways & Interactions
for SCGB1D2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCGB1D2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SCGB1D2 (O959693 ENSP000002449264) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SCGB1D2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SCGB1D2
Search CenterWatch for drugs/clinical trials and news about SCGB1D2 / SG1D2
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Transcripts
for SCGB1D2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCGB1D2 gene: NM_006551.3 Unigene Cluster for SCGB1D2: Secretoglobin, family 1D, member 2 Hs.204096 [show with all ESTs]Unigene Representative Sequence: BP3143771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000244926(uc001ntb.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCGB1D2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCGB1D2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SCGB1D2 (NM_006551) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCGB1D2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCGB1D2 |
Additional cDNA sequence: AJ224172.1 BC069290.1 BC104838.1 BC104840.1 1 DOTS entry: DT.431557 13 AceView cDNA sequences: AA299023 BC069290 AA335579 AW105433 AW103293 AW105434 AJ224172 AL708956 AW015055 NM_006551 BF591743 AA299198 AW105483
GeneLoc Exon Structure
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Expression
for SCGB1D2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCGB1D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAAACTTT
About this image
See SCGB1D2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCGB1D2
SOURCE GeneReport for Unigene cluster: Hs.204096
UniProtKB/Swiss-Prot: SG1D2_HUMAN, O95969Tissue specificity: Highest expression was found in skeletal muscle. Expressed as well in thymus, trachea, kidney,steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland
SABiosciences Custom PCR Arrays for SCGB1D2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCGB1D2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCGB1D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCGB1D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCGB1D2 |
Orthologs
for SCGB1D2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SCGB1D2 (if available)
TreeFam Gene Tree for SCGB1D2 (if available) |
Paralogs
for SCGB1D2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCGB1D2 gene
- SCGB1D12 SCGB1D42
3 SIMAP similar genes for SCGB1D2 using alignment to 1 protein entry: SG1D2_HUMAN:SCGB1D4 SCGB1D1 SCGB1C1
SCGB1D2 for paralogs About GeneDecksing
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Genomic Variants
for SCGB1D2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCGB1D2 (62009682 - 62012280 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCGB1D2: --
Human Gene Mutation Database (HGMD): SCGB1D2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCGB1D2 |
|
Disorders
/ Diseases
for SCGB1D2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCGB1D2 for disorders About GeneDecksing
OMIM gene information: 615061
OMIM disorders: --
5  diseases for SCGB1D2: About MalaCardsprostate cancer prostatitis pituitary adenoma breast cancer
adenoma
4 Novoseek disease relationships for SCGB1D2 gene About this table
Export disorders for SCGB1D2 gene to outside databases
|
Publications
for SCGB1D2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCGB1D2 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with SCGB1D2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Lipophilins: human peptides homologous to rat prostatein. (PubMed id 10066439)1, 2, 3 Zhao C.... Lehrer R.I. (1999)
- Update of the human secretoglobin (SCGB) gene superfa mily and an example of 'evolutionary bloom' of androgen-binding protein genes w ithin the mouse Scgb gene superfamily. (PubMed id 22155607)1, 3 Jackson B.C....Vasiliou V. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Lipophilin, a novel heterodimeric protein of human tears. (PubMed id 9720917)1, 3 Lehrer R.I....Glasgow B.J. (1998)
- Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation. (PubMed id 18630503)1, 9 Sjodin A....Hedman H. (2008)
- Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas. (PubMed id 15668787)1, 9 Sjodin A....Hedman H. (2005)
- Serum antibodies to lipophilin B detected in late stage breast cancer patients. (PubMed id 12576445)1, 9 Carter D....Houghton R.L. (2003)
- Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer. (PubMed id 12022875)1, 9 Carter D....Vedvick T.S. (2002)
- Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer. (PubMed id 17163411)1, 9 Culleton J....Duffy M.J. (2007)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for SCGB1D2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SCGB1D2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SCGB1D2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCGB1D2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for SCGB1D2 gene:
Search GeneIP for patents involving SCGB1D2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SCGB1D2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
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