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Aliases for SCGB1D2 Gene

Aliases for SCGB1D2 Gene

  • Secretoglobin, Family 1D Member 2 2 3
  • Secretoglobin, Family 1D, Member 2 3 5
  • Prostatein-Like Lipophilin B 2 3
  • Lipophilin-B 3 4
  • LPNB 3 4
  • Lipophilin B (Uteroglobin Family Member) 2
  • Prostatein-Like 2
  • LIPHB 4
  • LIPB 3
  • LPHB 3

External Ids for SCGB1D2 Gene

Previous GeneCards Identifiers for SCGB1D2 Gene

  • GC11P064523
  • GC11P063585
  • GC11P061785
  • GC11P061752
  • GC11P061766
  • GC11P062009
  • GC11P058338

Summaries for SCGB1D2 Gene

Entrez Gene Summary for SCGB1D2 Gene

  • The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCGB1D2 Gene

SCGB1D2 (Secretoglobin, Family 1D Member 2) is a Protein Coding gene. Diseases associated with SCGB1D2 include Breast Cancer. An important paralog of this gene is SCGB1D1.

UniProtKB/Swiss-Prot for SCGB1D2 Gene

  • May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Gene Wiki entry for SCGB1D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1D2 Gene

Genomics for SCGB1D2 Gene

Regulatory Elements for SCGB1D2 Gene

Enhancers for SCGB1D2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCGB1D2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCGB1D2 Gene

62,241,630 bp from pter
62,244,812 bp from pter
3,183 bases
Plus strand

Genomic View for SCGB1D2 Gene

Genes around SCGB1D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB1D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB1D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB1D2 Gene

Proteins for SCGB1D2 Gene

  • Protein details for SCGB1D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secretoglobin family 1D member 2
    Protein Accession:
    Secondary Accessions:
    • Q2M3N9

    Protein attributes for SCGB1D2 Gene

    90 amino acids
    Molecular mass:
    9925 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCGB1D2 Gene

Proteomics data for SCGB1D2 Gene at MOPED

Post-translational modifications for SCGB1D2 Gene

No Post-translational modifications

Other Protein References for SCGB1D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB1D2 Gene

Domains & Families for SCGB1D2 Gene

Gene Families for SCGB1D2 Gene

Protein Domains for SCGB1D2 Gene


Suggested Antigen Peptide Sequences for SCGB1D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the secretoglobin family. Lipophilin subfamily.
  • Belongs to the secretoglobin family. Lipophilin subfamily.
genes like me logo Genes that share domains with SCGB1D2: view

Function for SCGB1D2 Gene

Molecular function for SCGB1D2 Gene

UniProtKB/Swiss-Prot Function:
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Phenotypes for SCGB1D2 Gene

GenomeRNAi human phenotypes for SCGB1D2:
genes like me logo Genes that share phenotypes with SCGB1D2: view

Animal Model Products

miRNA for SCGB1D2 Gene

miRTarBase miRNAs that target SCGB1D2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCGB1D2 Gene

Localization for SCGB1D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1D2 Gene


Subcellular locations from

Jensen Localization Image for SCGB1D2 Gene COMPARTMENTS Subcellular localization image for SCGB1D2 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for SCGB1D2 Gene

Pathways & Interactions for SCGB1D2 Gene

SuperPathways for SCGB1D2 Gene

No Data Available

Interacting Proteins for SCGB1D2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000244926 O95969-SG1D2_HUMAN for SCGB1D2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SCGB1D2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SCGB1D2 Gene

Drugs & Compounds for SCGB1D2 Gene

No Compound Related Data Available

Transcripts for SCGB1D2 Gene

mRNA/cDNA for SCGB1D2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB1D2 Gene

Secretoglobin, family 1D, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1D2 Gene

No ASD Table

Relevant External Links for SCGB1D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCGB1D2 Gene

mRNA expression in normal human tissues for SCGB1D2 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB1D2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x16.4), Skin - Not Sun Exposed (Suprapubic) (x13.7), Cervix - Endocervix (x8.4), and Breast - Mammary Tissue (x7.6).

Protein differential expression in normal tissues from HIPED for SCGB1D2 Gene

This gene is overexpressed in Cervix (61.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB1D2 Gene

SOURCE GeneReport for Unigene cluster for SCGB1D2 Gene Hs.204096

mRNA Expression by UniProt/SwissProt for SCGB1D2 Gene

Tissue specificity: Highest expression was found in skeletal muscle. Expressed as well in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.
genes like me logo Genes that share expression patterns with SCGB1D2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for SCGB1D2 Gene

Orthologs for SCGB1D2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCGB1D 35
  • 68.89 (n)
  • 55.56 (a)
  • 49 (a)
(Pan troglodytes)
Mammalia SCGB1D2 35
  • 97.97 (n)
  • 96.34 (a)
SCGB1D2 36
  • 96 (a)
(Canis familiaris)
Mammalia -- 36
  • 51 (a)
-- 36
  • 52 (a)
Species with no ortholog for SCGB1D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB1D2 Gene

Gene Tree for SCGB1D2 (if available)
Gene Tree for SCGB1D2 (if available)

Paralogs for SCGB1D2 Gene

Paralogs for SCGB1D2 Gene

(3) SIMAP similar genes for SCGB1D2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCGB1D2: view

Variants for SCGB1D2 Gene

Sequence variations from dbSNP and Humsavar for SCGB1D2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2232950 - 62,243,391(+) CCCTC(C/T)GGAAG reference, missense
rs2276427 - 62,243,472(+) GGAAG(C/T)CCTGG reference, missense
rs1406385 -- 62,242,892(+) AGTCC(A/G)GCCTA intron-variant
rs1620121 -- 62,242,481(+) CTTTT(C/T)CTGTG intron-variant
rs1621989 -- 62,242,755(+) AGAGG(C/T)TATGA intron-variant

Variation tolerance for SCGB1D2 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB1D2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB1D2 Gene

Disorders for SCGB1D2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCGB1D2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SCGB1D2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCGB1D2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB1D2 Gene

Publications for SCGB1D2 Gene

  1. Lipophilins: human peptides homologous to rat prostatein. (PMID: 10066439) Zhao C. … Lehrer R.I. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 67
  2. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 3
  3. Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation. (PMID: 18630503) SjAPdin A. … Hedman H. (Anticancer Res. 2008) 3 23
  4. Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer. (PMID: 17163411) Culleton J. … Duffy M.J. (Int. J. Cancer 2007) 3 23
  5. Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas. (PMID: 15668787) SjAPdin A. … Hedman H. (Acta Neuropathol. 2005) 3 23

Products for SCGB1D2 Gene

Sources for SCGB1D2 Gene