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Aliases for SCGB1D2 Gene

Aliases for SCGB1D2 Gene

  • Secretoglobin, Family 1D, Member 2 2 3
  • LPNB 3 4 6
  • Prostatein-Like Lipophilin B 2 3
  • Lipophilin-B 3 4
  • Lipophilin B (Uteroglobin Family Member) 2
  • Secretoglobin Family 1D Member 2 3
  • Prostatein-Like 2
  • LIPHB 4
  • LIPB 3
  • LPHB 3

External Ids for SCGB1D2 Gene

Previous GeneCards Identifiers for SCGB1D2 Gene

  • GC11P064523
  • GC11P063585
  • GC11P061785
  • GC11P061752
  • GC11P061766
  • GC11P062009
  • GC11P058338

Summaries for SCGB1D2 Gene

Entrez Gene Summary for SCGB1D2 Gene

  • The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCGB1D2 Gene

SCGB1D2 (Secretoglobin, Family 1D, Member 2) is a Protein Coding gene. Diseases associated with SCGB1D2 include prostate cancer. An important paralog of this gene is SCGB1D1.

UniProtKB/Swiss-Prot for SCGB1D2 Gene

  • May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones

Gene Wiki entry for SCGB1D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1D2 Gene

Genomics for SCGB1D2 Gene

Regulatory Elements for SCGB1D2 Gene

Genomic Location for SCGB1D2 Gene

Start:
62,241,635 bp from pter
End:
62,244,808 bp from pter
Size:
3,174 bases
Orientation:
Plus strand

Genomic View for SCGB1D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCGB1D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB1D2 Gene

Proteins for SCGB1D2 Gene

  • Protein details for SCGB1D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95969-SG1D2_HUMAN
    Recommended name:
    Secretoglobin family 1D member 2
    Protein Accession:
    O95969
    Secondary Accessions:
    • Q2M3N9

    Protein attributes for SCGB1D2 Gene

    Size:
    90 amino acids
    Molecular mass:
    9925 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCGB1D2 Gene

Proteomics data for SCGB1D2 Gene at MOPED

Post-translational modifications for SCGB1D2 Gene

No Post-translational modifications

Other Protein References for SCGB1D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB1D2 Gene

Domains for SCGB1D2 Gene

Gene Families for SCGB1D2 Gene

HGNC:
  • SCGB :Secretoglobins

Protein Domains for SCGB1D2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB1D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95969

UniProtKB/Swiss-Prot:

SG1D2_HUMAN :
  • O95969
Family:
  • Belongs to the secretoglobin family. Lipophilin subfamily.
genes like me logo Genes that share domains with SCGB1D2: view

Function for SCGB1D2 Gene

Molecular function for SCGB1D2 Gene

UniProtKB/Swiss-Prot Function: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones

miRNA for SCGB1D2 Gene

miRTarBase miRNAs that target SCGB1D2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCGB1D2 Gene

Localization for SCGB1D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1D2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB1D2 Gene COMPARTMENTS Subcellular localization image for SCGB1D2 gene
Compartment Confidence
extracellular 4
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SCGB1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
genes like me logo Genes that share ontologies with SCGB1D2: view

Pathways for SCGB1D2 Gene

SuperPathways for SCGB1D2 Gene

No Data Available

Interacting Proteins for SCGB1D2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244926%0d%0a9606.ENSP00000227918%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000244926 O95969-SG1D2_HUMAN for SCGB1D2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SCGB1D2 Gene

None

No data available for Pathways by source for SCGB1D2 Gene

Transcripts for SCGB1D2 Gene

mRNA/cDNA for SCGB1D2 Gene

(13) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB1D2 Gene

Secretoglobin, family 1D, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1D2 Gene

No ASD Table

Relevant External Links for SCGB1D2 Gene

GeneLoc Exon Structure for
SCGB1D2
ECgene alternative splicing isoforms for
SCGB1D2

Expression for SCGB1D2 Gene

mRNA expression in normal human tissues for SCGB1D2 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB1D2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (16.4), Skin - Not Sun Exposed (Suprapubic) (13.7), Cervix - Endocervix (8.4), and Breast - Mammary Tissue (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCGB1D2 Gene

SOURCE GeneReport for Unigene cluster for SCGB1D2 Gene Hs.204096

mRNA Expression by UniProt/SwissProt for SCGB1D2 Gene

O95969-SG1D2_HUMAN
Tissue specificity: Highest expression was found in skeletal muscle. Expressed as well in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland
genes like me logo Genes that share expressions with SCGB1D2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCGB1D2 Gene

Orthologs for SCGB1D2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB1D2 35
  • 97.97 (n)
  • 96.34 (a)
SCGB1D2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCGB1D 35
  • 68.89 (n)
  • 55.56 (a)
SCGB1D 36
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 19 16
Species with no ortholog for SCGB1D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB1D2 Gene

ENSEMBL:
Gene Tree for SCGB1D2 (if available)
TreeFam:
Gene Tree for SCGB1D2 (if available)

Paralogs for SCGB1D2 Gene

Paralogs for SCGB1D2 Gene

Selected SIMAP similar genes for SCGB1D2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCGB1D2: view

Variants for SCGB1D2 Gene

Sequence variations from dbSNP and Humsavar for SCGB1D2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1406385 -- 62,242,892(+) AGTCC(A/G)GCCTA intron-variant
rs1620121 -- 62,242,481(+) CTTTT(C/T)CTGTG intron-variant
rs1621989 -- 62,242,755(+) AGAGG(C/T)TATGA intron-variant
rs1729355 -- 62,244,342(+) CTGCA(A/G)GAACC intron-variant
rs1729382 -- 62,239,695(+) TCAAA(A/T)GTAAG upstream-variant-2KB

Relevant External Links for SCGB1D2 Gene

HapMap Linkage Disequilibrium report
SCGB1D2
Human Gene Mutation Database (HGMD)
SCGB1D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB1D2 Gene

Disorders for SCGB1D2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SCGB1D2 Gene including...

Search for SCGB1D2 Gene in MalaCards »

(4) Novoseek inferred disease relationships for SCGB1D2 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 47.4 8
breast carcinoma 43 1
tumors 24.1 9
cancer 3.79 1

Relevant External Links for SCGB1D2

Genetic Association Database (GAD)
SCGB1D2
genes like me logo Genes that share disorders with SCGB1D2: view

No data available for UniProtKB/Swiss-Prot for SCGB1D2 Gene

Publications for SCGB1D2 Gene

  1. Lipophilins: human peptides homologous to rat prostatein. (PMID: 10066439) Zhao C. … Lehrer R.I. (Biochem. Biophys. Res. Commun. 1999) 2 3 4
  2. Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer. (PMID: 17163411) Culleton J. … Duffy M.J. (Int. J. Cancer 2007) 3 23
  3. Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation. (PMID: 18630503) SjAPdin A. … Hedman H. (Anticancer Res. 2008) 3 23
  4. Lipophilin, a novel heterodimeric protein of human tears. (PMID: 9720917) Lehrer R.I. … Glasgow B.J. (FEBS Lett. 1998) 2 3
  5. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 3

Products for SCGB1D2 Gene

Sources for SCGB1D2 Gene

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