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Aliases for SCGB1D1 Gene

Aliases for SCGB1D1 Gene

  • Secretoglobin Family 1D Member 1 2 3 5
  • Lipophilin A (Uteroglobin Family Member) 2 3
  • Prostatein-Like Lipophilin A 2 3
  • Lipophilin-A 3 4
  • LPNA 3 4
  • LIPHA 4
  • LIPA 3
  • LPHA 3

External Ids for SCGB1D1 Gene

Previous GeneCards Identifiers for SCGB1D1 Gene

  • GC11P064471
  • GC11P063533
  • GC11P061733
  • GC11P061714
  • GC11P061957
  • GC11P058286

Summaries for SCGB1D1 Gene

Entrez Gene Summary for SCGB1D1 Gene

  • The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. This gene product represents one component of a heterodimeric molecule present in human tears whose elution profile is consistent with prostatein, a tetrameric molecule composed of three peptide components in heterodimers. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 15, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCGB1D1 Gene

SCGB1D1 (Secretoglobin Family 1D Member 1) is a Protein Coding gene. Diseases associated with SCGB1D1 include Patellofemoral Pain Syndrome. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is SCGB1D2.

UniProtKB/Swiss-Prot for SCGB1D1 Gene

  • May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1D1 Gene

Genomics for SCGB1D1 Gene

Regulatory Elements for SCGB1D1 Gene

Enhancers for SCGB1D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F062041 1.4 Ensembl ENCODE 16.2 -144.8 -144789 8.1 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC MEF2D METTL12 INTS5 SNHG1 NXF1 TMEM138 LOC105369332 VPS37C EML3 MTA2 TAF6L
GH11F062724 0.2 ENCODE 16.2 +537.0 536954 6.2 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 TTC9C SCGB1D1 EEF1DP8 ENSG00000203520 IMMP1LP1 HNRNPUL2 EEF1G TAF6L LRRN4CL METTL12
GH11F062878 1.1 ENCODE 16.2 +691.6 691617 5.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SNHG1 SCGB1D1 EEF1DP8 ENSG00000203520 INTS5 NXF1 UBXN1 SLC3A2 SNORD28 ENSG00000257002
GH11F061330 0.6 ENCODE 16.2 -856.3 -856273 6.0 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ENSG00000256733 ENSG00000255959 ENSG00000255845 LINC00301 SCGB1D1 EEF1DP8 MS4A5 MS4A13 LOC105369323 TMEM216
GH11F062645 0.6 ENCODE 16.2 +456.1 456149 2.7 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS EML3 SCGB1D1 EEF1DP8 ENSG00000203520 GANAB B3GAT3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SCGB1D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCGB1D1 Gene

Chromosome:
11
Start:
62,190,216 bp from pter
End:
62,193,539 bp from pter
Size:
3,324 bases
Orientation:
Plus strand

Genomic View for SCGB1D1 Gene

Genes around SCGB1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB1D1 Gene

Proteins for SCGB1D1 Gene

  • Protein details for SCGB1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95968-SG1D1_HUMAN
    Recommended name:
    Secretoglobin family 1D member 1
    Protein Accession:
    O95968

    Protein attributes for SCGB1D1 Gene

    Size:
    90 amino acids
    Molecular mass:
    9898 Da
    Quaternary structure:
    • Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head.

neXtProt entry for SCGB1D1 Gene

Post-translational modifications for SCGB1D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB1D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB1D1 Gene

Domains & Families for SCGB1D1 Gene

Gene Families for SCGB1D1 Gene

Protein Domains for SCGB1D1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB1D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95968

UniProtKB/Swiss-Prot:

SG1D1_HUMAN :
  • Belongs to the secretoglobin family. Lipophilin subfamily.
Family:
  • Belongs to the secretoglobin family. Lipophilin subfamily.
genes like me logo Genes that share domains with SCGB1D1: view

Function for SCGB1D1 Gene

Molecular function for SCGB1D1 Gene

UniProtKB/Swiss-Prot Function:
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Gene Ontology (GO) - Molecular Function for SCGB1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046982 protein heterodimerization activity IDA 9720917
genes like me logo Genes that share ontologies with SCGB1D1: view
genes like me logo Genes that share phenotypes with SCGB1D1: view

Animal Model Products

miRNA for SCGB1D1 Gene

miRTarBase miRNAs that target SCGB1D1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCGB1D1 Gene

Localization for SCGB1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1D1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB1D1 Gene COMPARTMENTS Subcellular localization image for SCGB1D1 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCGB1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA,TAS 9720917
genes like me logo Genes that share ontologies with SCGB1D1: view

Pathways & Interactions for SCGB1D1 Gene

SuperPathways for SCGB1D1 Gene

No Data Available

Interacting Proteins for SCGB1D1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303070%0d%0a9606.ENSP00000244930%0d%0a
Selected Interacting proteins: O95968-SG1D1_HUMAN ENSP00000303070 for SCGB1D1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SCGB1D1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCGB1D1 Gene

Transcripts for SCGB1D1 Gene

mRNA/cDNA for SCGB1D1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB1D1 Gene

Secretoglobin, family 1D, member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1D1 Gene

No ASD Table

Relevant External Links for SCGB1D1 Gene

GeneLoc Exon Structure for
SCGB1D1
ECgene alternative splicing isoforms for
SCGB1D1

Expression for SCGB1D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCGB1D1 Gene

Protein differential expression in normal tissues from HIPED for SCGB1D1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB1D1 Gene



Protein tissue co-expression partners for SCGB1D1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCGB1D1 Gene:

SCGB1D1

SOURCE GeneReport for Unigene cluster for SCGB1D1 Gene:

Hs.202686

mRNA Expression by UniProt/SwissProt for SCGB1D1 Gene:

O95968-SG1D1_HUMAN
Tissue specificity: Expressed in lachrymal gland, thymus, kidney, testis, ovary and salivary gland.
genes like me logo Genes that share expression patterns with SCGB1D1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SCGB1D1 Gene

Orthologs for SCGB1D1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB1D1 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SCGB1D 35
  • 44 (a)
OneToMany
Species where no ortholog for SCGB1D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB1D1 Gene

ENSEMBL:
Gene Tree for SCGB1D1 (if available)
TreeFam:
Gene Tree for SCGB1D1 (if available)

Paralogs for SCGB1D1 Gene

Paralogs for SCGB1D1 Gene

(2) SIMAP similar genes for SCGB1D1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCGB1D1: view

Variants for SCGB1D1 Gene

Sequence variations from dbSNP and Humsavar for SCGB1D1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111510162 -- 62,189,996(+) GGACA(C/G)TCACC upstream-variant-2KB
rs112105908 -- 62,190,484(+) GCTCA(C/T)AAAGC intron-variant
rs112274197 -- 62,189,052(+) CCTGC(A/G)GGGAG upstream-variant-2KB
rs11230972 -- 62,188,468(+) GAGAC(A/G)GGGTT upstream-variant-2KB
rs11230973 -- 62,190,870(+) GACTC(A/G)TAAAA intron-variant

Variation tolerance for SCGB1D1 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB1D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB1D1 Gene

Disorders for SCGB1D1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCGB1D1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
patellofemoral pain syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SCGB1D1

Genetic Association Database (GAD)
SCGB1D1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCGB1D1
genes like me logo Genes that share disorders with SCGB1D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB1D1 Gene

Publications for SCGB1D1 Gene

  1. Lipophilins: human peptides homologous to rat prostatein. (PMID: 10066439) Zhao C. … Lehrer R.I. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. Lipophilin, a novel heterodimeric protein of human tears. (PMID: 9720917) Lehrer R.I. … Glasgow B.J. (FEBS Lett. 1998) 2 3 4 22 64
  3. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SCGB1D1 Gene

Sources for SCGB1D1 Gene

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