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Aliases for SCGB1D1 Gene

Aliases for SCGB1D1 Gene

  • Secretoglobin, Family 1D, Member 1 2 3
  • Lipophilin A (Uteroglobin Family Member) 2 3
  • Prostatein-Like Lipophilin A 2 3
  • Lipophilin-A 3 4
  • LPNA 3 4
  • LIPHA 4
  • LIPA 3
  • LPHA 3

External Ids for SCGB1D1 Gene

Previous GeneCards Identifiers for SCGB1D1 Gene

  • GC11P064471
  • GC11P063533
  • GC11P061733
  • GC11P061714
  • GC11P061957
  • GC11P058286

Summaries for SCGB1D1 Gene

Entrez Gene Summary for SCGB1D1 Gene

  • The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. This gene product represents one component of a heterodimeric molecule present in human tears whose elution profile is consistent with prostatein, a tetrameric molecule composed of three peptide components in heterodimers. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 15, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCGB1D1 Gene

SCGB1D1 (Secretoglobin, Family 1D, Member 1) is a Protein Coding gene. Diseases associated with SCGB1D1 include patellofemoral pain syndrome. Among its related pathways are Lysosome and cholesterol biosynthesis II (via 24,25-dihydrolanosterol). GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is SCGB1D2.

UniProtKB/Swiss-Prot for SCGB1D1 Gene

  • May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1D1 Gene

Genomics for SCGB1D1 Gene

Regulatory Elements for SCGB1D1 Gene

Genomic Location for SCGB1D1 Gene

62,190,216 bp from pter
62,193,539 bp from pter
3,324 bases
Plus strand

Genomic View for SCGB1D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCGB1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB1D1 Gene

Proteins for SCGB1D1 Gene

  • Protein details for SCGB1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secretoglobin family 1D member 1
    Protein Accession:

    Protein attributes for SCGB1D1 Gene

    90 amino acids
    Molecular mass:
    9898 Da
    Quaternary structure:
    • Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head

neXtProt entry for SCGB1D1 Gene

Proteomics data for SCGB1D1 Gene at MOPED

Post-translational modifications for SCGB1D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB1D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB1D1 Gene

Domains & Families for SCGB1D1 Gene

Gene Families for SCGB1D1 Gene

Protein Domains for SCGB1D1 Gene


Suggested Antigen Peptide Sequences for SCGB1D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the secretoglobin family. Lipophilin subfamily.
  • Belongs to the secretoglobin family. Lipophilin subfamily.
genes like me logo Genes that share domains with SCGB1D1: view

Function for SCGB1D1 Gene

Molecular function for SCGB1D1 Gene

UniProtKB/Swiss-Prot Function:
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones

Gene Ontology (GO) - Molecular Function for SCGB1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046982 protein heterodimerization activity IDA 9720917
genes like me logo Genes that share ontologies with SCGB1D1: view
genes like me logo Genes that share phenotypes with SCGB1D1: view

Animal Model Products

miRNA for SCGB1D1 Gene

miRTarBase miRNAs that target SCGB1D1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCGB1D1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SCGB1D1 Gene

Localization for SCGB1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1D1 Gene


Subcellular locations from

Jensen Localization Image for SCGB1D1 Gene COMPARTMENTS Subcellular localization image for SCGB1D1 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCGB1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9720917
genes like me logo Genes that share ontologies with SCGB1D1: view

Pathways & Interactions for SCGB1D1 Gene

genes like me logo Genes that share pathways with SCGB1D1: view

Pathways by source for SCGB1D1 Gene

1 BioSystems pathway for SCGB1D1 Gene
2 KEGG pathways for SCGB1D1 Gene

Interacting Proteins for SCGB1D1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000303070 O95968-SG1D1_HUMAN for SCGB1D1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SCGB1D1 Gene


No data available for SIGNOR curated interactions for SCGB1D1 Gene

Drugs & Compounds for SCGB1D1 Gene

No Compound Related Data Available

Transcripts for SCGB1D1 Gene

mRNA/cDNA for SCGB1D1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB1D1 Gene

Secretoglobin, family 1D, member 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCGB1D1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1D1 Gene

No ASD Table

Relevant External Links for SCGB1D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCGB1D1 Gene

mRNA expression in normal human tissues for SCGB1D1 Gene

Protein differential expression in normal tissues from HIPED for SCGB1D1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB1D1 Gene

SOURCE GeneReport for Unigene cluster for SCGB1D1 Gene Hs.202686

mRNA Expression by UniProt/SwissProt for SCGB1D1 Gene

Tissue specificity: Expressed in lachrymal gland, thymus, kidney, testis, ovary and salivary gland
genes like me logo Genes that share expression patterns with SCGB1D1: view

Protein tissue co-expression partners for SCGB1D1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SCGB1D1 Gene

Orthologs for SCGB1D1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCGB1D1 35
  • 99.26 (n)
  • 100 (a)
SCGB1D1 36
  • 100 (a)
(Bos Taurus)
Mammalia SCGB1D 36
  • 44 (a)
(Canis familiaris)
Mammalia -- 36
  • 44 (a)
-- 36
  • 45 (a)
Species with no ortholog for SCGB1D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB1D1 Gene

Gene Tree for SCGB1D1 (if available)
Gene Tree for SCGB1D1 (if available)

Paralogs for SCGB1D1 Gene

Paralogs for SCGB1D1 Gene

(2) SIMAP similar genes for SCGB1D1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCGB1D1: view

Variants for SCGB1D1 Gene

Sequence variations from dbSNP and Humsavar for SCGB1D1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1622788 -- 62,190,544(-) CCTGC(A/C)TTGAT intron-variant
rs2232930 -- 62,189,437(+) GCAGC(A/T)CCTTG upstream-variant-2KB
rs2232931 -- 62,189,598(+) GGAGT(A/G)AGACA upstream-variant-2KB
rs2232932 -- 62,189,665(+) TGTAT(G/T)CAGCT upstream-variant-2KB
rs2232933 -- 62,189,753(+) ATCTA(C/T)GTGCA upstream-variant-2KB

Variation tolerance for SCGB1D1 Gene

Residual Variation Intolerance Score: 74.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB1D1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB1D1 Gene

Disorders for SCGB1D1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCGB1D1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
patellofemoral pain syndrome
- elite association

Relevant External Links for SCGB1D1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCGB1D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB1D1 Gene

Publications for SCGB1D1 Gene

  1. Lipophilins: human peptides homologous to rat prostatein. (PMID: 10066439) Zhao C. … Lehrer R.I. (Biochem. Biophys. Res. Commun. 1999) 2 23 67
  2. Lipophilin, a novel heterodimeric protein of human tears. (PMID: 9720917) Lehrer R.I. … Glasgow B.J. (FEBS Lett. 1998) 2 23 67
  3. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 67
  4. The Neisseria meningitidis capsule is important for intracellular survival in human cells. (PMID: 17470547) Spinosa M.R. … Bucci C. (Infect. Immun. 2007) 23 67
  5. Immunohistochemical analysis of secretoglobin SCGB 2A1 expression in human ocular glands and tissues. (PMID: 16395610) Stoeckelhuber M. … Klug J. (Histochem. Cell Biol. 2006) 23 67

Products for SCGB1D1 Gene

Sources for SCGB1D1 Gene

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