Aliases for SCGB1D1 Gene
External Ids for SCGB1D1 Gene
Previous GeneCards Identifiers for SCGB1D1 Gene
The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. This gene product represents one component of a heterodimeric molecule present in human tears whose elution profile is consistent with prostatein, a tetrameric molecule composed of three peptide components in heterodimers. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 15, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]
GeneCards Summary for SCGB1D1 Gene
SCGB1D1 (Secretoglobin Family 1D Member 1) is a Protein Coding gene. Diseases associated with SCGB1D1 include patellofemoral pain syndrome and intracranial hypotension. Among its related pathways are Lysosome and Phase I, non P450. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is SCGB1D2.
UniProtKB/Swiss-Prot for SCGB1D1 Gene
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.