SCGB1D1 Gene
protein-coding GIFtS: 47
GCID: GC11P061957
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secretoglobin, family 1D, member 1
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Aliases
for SCGB1D1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Secretoglobin, Family 1D, Member 11 2 | | Lipophilin-A3 | | LIPA1 2 | | Prostatein-Like Lipophilin A2 | | LPHA1 2 | | Secretoglobin Family 1D Member 12 | | MGC719581 | | LIPHA3 | | LPNA2 | | Lipophilin-A3 | | Lipophilin A (Uteroglobin Family Member)2 | | |
Export aliases for SCGB1D1 gene to outside databasesPrevious GC identifers: GC11P064471 GC11P063533 GC11P062208 GC11P061733 GC11P061714 GC11P058286 |
Summaries
for SCGB1D1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SCGB1D1:
The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and isan ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. This gene productrepresents one component of a heterodimeric molecule present in human tears whose elution profile is consistent withprostatein, a tetrameric molecule composed of three peptide components in heterodimers. Assuming that humanlipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroidhormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, achemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 15,this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: SG1D1_HUMAN, O95968Function: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostatecancer. May be under transcriptional regulation of steroid hormones
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Genomic Views
for SCGB1D1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCGB1D1 gene promoter:
TBP MEF-2A NRSF form 1 aMEF-2 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCGB1D1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCGB1D1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q13SCGB1D1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P061957: view genomic region
(about GC identifiers)
Start:
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61,957,688 bp from pter |
End:
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61,961,011 bp from pter |
Size:
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3,324 bases |
Orientation:
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plus strand |
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Proteins
for SCGB1D1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SG1D1_HUMAN, O95968 (See
protein sequence)Recommended Name: Secretoglobin family 1D member 1 precursor Size: 90 amino acids; 9898 Da
Subunit: Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head
Subcellular location: Secreted (Potential)
Mass spectrometry: Mass=7574.69; Method=Electrospray; Range=22-90; Source=PubMed:9720917;Explore the universe of human proteins at neXtProt for SCGB1D1: NX_O95968
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95968
SCGB1D1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006543.1
ENSEMBL proteins: ENSP00000303070
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
SCGB1D1 for ontologies About GeneDecksing
SCGB1D1 Antibody Products:
Assay Products for SCGB1D1: |
Protein
Domains /
Families
for SCGB1D1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCGB1D1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95968ProtoNet protein and cluster: O95968 UniProtKB/Swiss-Prot: SG1D1_HUMAN, O95968Similarity: Belongs to the secretoglobin family. Lipophilin subfamily |
Function
for SCGB1D1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SG1D1_HUMAN, O95968Function: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostatecancer. May be under transcriptional regulation of steroid hormones
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCGB1D1
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCGB1D1 |
1 GenomeRNAi human phenotype for SCGB1D1:
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Pathways & Interactions
for SCGB1D1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCGB1D1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SCGB1D1 (O959683 ENSP000003030704) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for SCGB1D1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SCGB1D1
Search CenterWatch for drugs/clinical trials and news about SCGB1D1 / SG1D1
|
Transcripts
for SCGB1D1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCGB1D1 gene: NM_006552.1 Unigene Cluster for SCGB1D1: Secretoglobin, family 1D, member 1 Hs.202686 [show with all ESTs]Unigene Representative Sequence: CB9875821 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000306238(uc001nsz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCGB1D1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCGB1D1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SCGB1D1 (NM_006552) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCGB1D1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCGB1D1 |
Additional cDNA sequence: AJ224171.1 BC062693.1 BC069170.1 BC069289.1 1 DOTS entry: DT.92037292 14 AceView cDNA sequences: NM_006552 CA946451 BC069170 CK430411 CD723001 BC069289 AJ224171 CB957594 CB987851 CB956606 CD722937 BC062693 CK431208 CB987582
GeneLoc Exon Structure
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Expression
for SCGB1D1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCGB1D1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGCTGTCGG
About this image
See SCGB1D1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCGB1D1
SOURCE GeneReport for Unigene cluster: Hs.202686
UniProtKB/Swiss-Prot: SG1D1_HUMAN, O95968Tissue specificity: Expressed in lachrymal gland, thymus, kidney, testis, ovary and salivary gland
SABiosciences Custom PCR Arrays for SCGB1D1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCGB1D1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCGB1D1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCGB1D1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCGB1D1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCGB1D1 |
Orthologs
for SCGB1D1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SCGB1D1 (if available)
TreeFam Gene Tree for SCGB1D1 (if available) |
Paralogs
for SCGB1D1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCGB1D1 gene
- SCGB1D22 SCGB1D42
2 SIMAP similar genes for SCGB1D1 using alignment to 1 protein entry: SG1D1_HUMAN:SCGB1D4 SCGB1D2
SCGB1D1 for paralogs About GeneDecksing
|
Genomic Variants
for SCGB1D1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCGB1D1 (61957688 - 61961011 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCGB1D1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCGB1D1 |
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Disorders
/ Diseases
for SCGB1D1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCGB1D1 for disorders About GeneDecksing
OMIM gene information: 615060
OMIM disorders: --
6  diseases for SCGB1D1: About MalaCardsprostate cancer prostatitis patellofemoral pain syndrome intracranial hypotension
paine syndrome lung cancer
2 diseases from the University of Copenhagen DISEASES database for SCGB1D1:Patellofemoral pain syndrome Intracranial hypotension 1 Novoseek disease relationship for SCGB1D1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
16120813 (1) |
Export disorders for SCGB1D1 gene to outside databases
|
Publications
for SCGB1D1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCGB1D1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SCGB1D1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Lipophilins: human peptides homologous to rat prostatein. (PubMed id 10066439)1, 2, 3, 9 Zhao C.... Lehrer R.I. (1999)
- Lipophilin, a novel heterodimeric protein of human tears. (PubMed id 9720917)1, 2, 3, 9 Lehrer R.I....Glasgow B.J. (1998)
- Update of the human secretoglobin (SCGB) gene superfa mily and an example of 'evolutionary bloom' of androgen-binding protein genes w ithin the mouse Scgb gene superfamily. (PubMed id 22155607)1, 3 Jackson B.C....Vasiliou V. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Evaluation of lipophilins as determinants of tumor cell response to estramustine. (PubMed id 16120813)9 Tucker J.M....Tew K.D. (2005)
- Dysregulated secretoglobin expression in human lung cancers. (PubMed id 12826312)9 Sjodin A....Hedman H. (2003)
- The Neisseria meningitidis capsule is important for intracellular survival in human cells. (PubMed id 17470547)9 Spinosa M.R....Bucci C. (2007)
- Immunohistochemical analysis of secretoglobin SCGB 2A1 expression in human ocular glands and tissues. (PubMed id 16395610)9 Stoeckelhuber M....Klug J. (2006)
- Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors. (PubMed id 16020486)9 Xiao F....Klug J. (2005)
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External Searches for SCGB1D1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SCGB1D1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCGB1D1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCGB1D1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SCGB1D1 gene:
Search GeneIP for patents involving SCGB1D1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCGB1D1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SCGB1D1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCGB1D1 |
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