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Aliases for SCGB1C1 Gene

Aliases for SCGB1C1 Gene

  • Secretoglobin Family 1C Member 1 2 3 5
  • Secretoglobin RYD5 3 4
  • Ligand Binding Protein RYD5 3
  • RYD5 3

External Ids for SCGB1C1 Gene

Previous GeneCards Identifiers for SCGB1C1 Gene

  • GC11P000187
  • GC11P000012

Summaries for SCGB1C1 Gene

GeneCards Summary for SCGB1C1 Gene

SCGB1C1 (Secretoglobin Family 1C Member 1) is a Protein Coding gene. An important paralog of this gene is SCGB1C2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1C1 Gene

Genomics for SCGB1C1 Gene

Regulatory Elements for SCGB1C1 Gene

Enhancers for SCGB1C1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SCGB1C1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCGB1C1 Gene

Chromosome:
11
Start:
187,899 bp from pter
End:
194,575 bp from pter
Size:
6,677 bases
Orientation:
Plus strand

Genomic View for SCGB1C1 Gene

Genes around SCGB1C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB1C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB1C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB1C1 Gene

Proteins for SCGB1C1 Gene

  • Protein details for SCGB1C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD33-SG1C1_HUMAN
    Recommended name:
    Secretoglobin family 1C member 1
    Protein Accession:
    Q8TD33
    Secondary Accessions:
    • A8MSI9
    • Q14DW0

    Protein attributes for SCGB1C1 Gene

    Size:
    95 amino acids
    Molecular mass:
    10414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCGB1C1 Gene

Post-translational modifications for SCGB1C1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB1C1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB1C1 Gene

Domains & Families for SCGB1C1 Gene

Gene Families for SCGB1C1 Gene

Protein Domains for SCGB1C1 Gene

Suggested Antigen Peptide Sequences for SCGB1C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD33

UniProtKB/Swiss-Prot:

SG1C1_HUMAN :
  • Belongs to the secretoglobin family.
Family:
  • Belongs to the secretoglobin family.
genes like me logo Genes that share domains with SCGB1C1: view

Function for SCGB1C1 Gene

Phenotypes for SCGB1C1 Gene

genes like me logo Genes that share phenotypes with SCGB1C1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCGB1C1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB1C1 Gene

Localization for SCGB1C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1C1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB1C1 Gene COMPARTMENTS Subcellular localization image for SCGB1C1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SCGB1C1: view

Pathways & Interactions for SCGB1C1 Gene

SuperPathways for SCGB1C1 Gene

No Data Available

Interacting Proteins for SCGB1C1 Gene

Gene Ontology (GO) - Biological Process for SCGB1C1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCGB1C1 Gene

Drugs & Compounds for SCGB1C1 Gene

No Compound Related Data Available

Transcripts for SCGB1C1 Gene

mRNA/cDNA for SCGB1C1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB1C1 Gene

Secretoglobin, family 1C, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1C1 Gene

No ASD Table

Relevant External Links for SCGB1C1 Gene

GeneLoc Exon Structure for
SCGB1C1
ECgene alternative splicing isoforms for
SCGB1C1

Expression for SCGB1C1 Gene

mRNA expression in normal human tissues for SCGB1C1 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB1C1 Gene

This gene is overexpressed in Whole Blood (x17.6) and Pancreas (x10.9).

Protein differential expression in normal tissues from HIPED for SCGB1C1 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB1C1 Gene



Protein tissue co-expression partners for SCGB1C1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCGB1C1 Gene:

SCGB1C1

SOURCE GeneReport for Unigene cluster for SCGB1C1 Gene:

Hs.127059
genes like me logo Genes that share expression patterns with SCGB1C1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SCGB1C1 Gene

Orthologs for SCGB1C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1C1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCGB1C1 35
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCGB1C1 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scgb1c1 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCGB1C1 35
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCGB1C1 35
  • 96 (a)
OneToOne
Species where no ortholog for SCGB1C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB1C1 Gene

ENSEMBL:
Gene Tree for SCGB1C1 (if available)
TreeFam:
Gene Tree for SCGB1C1 (if available)

Paralogs for SCGB1C1 Gene

Paralogs for SCGB1C1 Gene

(2) SIMAP similar genes for SCGB1C1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCGB1C1: view

Variants for SCGB1C1 Gene

Sequence variations from dbSNP and Humsavar for SCGB1C1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2686894 - 193,865(-) CATCT(A/C/G)TACAG reference, missense
rs1108819 -- 194,331(+) CCCCC(A/C/G)CACTG intron-variant
rs1722247 -- 188,761(+) acata(C/T)gatgg intron-variant
rs7943968 -- 191,910(-) Cggta(A/G)gggtt intron-variant, upstream-variant-2KB
rs7951297 -- 193,112(-) GGCAC(A/G)GCTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SCGB1C1 Gene

Variant ID Type Subtype PubMed ID
dgv1504n54 CNV gain 21841781
esv22231 CNV gain 19812545
esv2470450 CNV insertion 19546169
esv3625060 CNV gain 21293372
nsv1077328 CNV duplication 25765185
nsv1110190 CNV duplication 24896259
nsv1124633 CNV duplication 24896259
nsv1148110 CNV duplication 26484159
nsv552757 CNV loss 21841781

Variation tolerance for SCGB1C1 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.77; 93.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB1C1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB1C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB1C1 Gene

Disorders for SCGB1C1 Gene

Relevant External Links for SCGB1C1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCGB1C1

No disorders were found for SCGB1C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCGB1C1 Gene

Publications for SCGB1C1 Gene

  1. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 3 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. (PMID: 12406855) Reynolds S.D. … Stripp B.R. (Am. J. Respir. Crit. Care Med. 2002) 3 4 65
  4. Single-Nucleotide Polymorphisms on the RYD5 Gene in Nasal Polyposis. (PMID: 26204469) A9zdaA9 S. … Dere H. (DNA Cell Biol. 2015) 3 65
  5. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PMID: 24026423) Shameer K. … Kullo I.J. (Hum. Genet. 2014) 3 65

Products for SCGB1C1 Gene

Sources for SCGB1C1 Gene

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