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Aliases for SCGB1C1 Gene

Aliases for SCGB1C1 Gene

  • Secretoglobin Family 1C Member 1 2 3
  • Secretoglobin, Family 1C, Member 1 3 5
  • Secretoglobin RYD5 3 4
  • Ligand Binding Protein RYD5 3
  • RYD5 3

External Ids for SCGB1C1 Gene

Previous GeneCards Identifiers for SCGB1C1 Gene

  • GC11P000187
  • GC11P000012

Summaries for SCGB1C1 Gene

GeneCards Summary for SCGB1C1 Gene

SCGB1C1 (Secretoglobin Family 1C Member 1) is a Protein Coding gene. An important paralog of this gene is SCGB1C2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1C1 Gene

Genomics for SCGB1C1 Gene

Genomic Location for SCGB1C1 Gene

Chromosome:
11
Start:
187,899 bp from pter
End:
194,575 bp from pter
Size:
6,677 bases
Orientation:
Plus strand

Genomic View for SCGB1C1 Gene

Genes around SCGB1C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB1C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB1C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB1C1 Gene

No data available for Regulatory Elements for SCGB1C1 Gene

Proteins for SCGB1C1 Gene

  • Protein details for SCGB1C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD33-SG1C1_HUMAN
    Recommended name:
    Secretoglobin family 1C member 1
    Protein Accession:
    Q8TD33
    Secondary Accessions:
    • A8MSI9
    • Q14DW0

    Protein attributes for SCGB1C1 Gene

    Size:
    95 amino acids
    Molecular mass:
    10414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCGB1C1 Gene

Proteomics data for SCGB1C1 Gene at MOPED

Post-translational modifications for SCGB1C1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB1C1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB1C1 Gene

Domains & Families for SCGB1C1 Gene

Gene Families for SCGB1C1 Gene

Protein Domains for SCGB1C1 Gene

Suggested Antigen Peptide Sequences for SCGB1C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD33

UniProtKB/Swiss-Prot:

SG1C1_HUMAN :
  • Belongs to the secretoglobin family.
Family:
  • Belongs to the secretoglobin family.
genes like me logo Genes that share domains with SCGB1C1: view

Function for SCGB1C1 Gene

Phenotypes for SCGB1C1 Gene

GenomeRNAi human phenotypes for SCGB1C1:
genes like me logo Genes that share phenotypes with SCGB1C1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCGB1C1

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB1C1 Gene

Localization for SCGB1C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1C1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB1C1 Gene COMPARTMENTS Subcellular localization image for SCGB1C1 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for SCGB1C1 Gene

Pathways & Interactions for SCGB1C1 Gene

SuperPathways for SCGB1C1 Gene

No Data Available

Interacting Proteins for SCGB1C1 Gene

Gene Ontology (GO) - Biological Process for SCGB1C1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCGB1C1 Gene

Drugs & Compounds for SCGB1C1 Gene

No Compound Related Data Available

Transcripts for SCGB1C1 Gene

mRNA/cDNA for SCGB1C1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB1C1 Gene

Secretoglobin, family 1C, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1C1 Gene

No ASD Table

Relevant External Links for SCGB1C1 Gene

GeneLoc Exon Structure for
SCGB1C1
ECgene alternative splicing isoforms for
SCGB1C1

Expression for SCGB1C1 Gene

mRNA expression in normal human tissues for SCGB1C1 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB1C1 Gene

This gene is overexpressed in Whole Blood (x17.6) and Pancreas (x10.9).

Protein differential expression in normal tissues from HIPED for SCGB1C1 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB1C1 Gene



SOURCE GeneReport for Unigene cluster for SCGB1C1 Gene Hs.127059

genes like me logo Genes that share expression patterns with SCGB1C1: view

Protein tissue co-expression partners for SCGB1C1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SCGB1C1 Gene

Orthologs for SCGB1C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1C1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB1C1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCGB1C1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCGB1C1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scgb1c1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCGB1C1 36
  • 51 (a)
OneToOne
Species with no ortholog for SCGB1C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB1C1 Gene

ENSEMBL:
Gene Tree for SCGB1C1 (if available)
TreeFam:
Gene Tree for SCGB1C1 (if available)

Paralogs for SCGB1C1 Gene

Paralogs for SCGB1C1 Gene

(2) SIMAP similar genes for SCGB1C1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCGB1C1: view

Variants for SCGB1C1 Gene

Sequence variations from dbSNP and Humsavar for SCGB1C1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2686894 - 193,865(-) CATCT(A/C/G)TACAG reference, missense
rs2354747 -- 191,355(-) TTTGT(A/G)TCATT intron-variant, upstream-variant-2KB
rs2354748 -- 191,210(-) TATAT(C/G)CATAT intron-variant, upstream-variant-2KB
rs2354750 -- 190,567(-) AATCC(A/C)AAATA intron-variant
rs2354751 -- 190,488(-) AATAA(A/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCGB1C1 Gene

Variant ID Type Subtype PubMed ID
dgv910n71 CNV Gain 21882294
esv22231 CNV Gain 19812545
nsv896436 CNV Gain 21882294
nsv896437 CNV Loss 21882294
dgv911n71 CNV Gain 21882294
esv2470450 CNV Insertion 19546169

Variation tolerance for SCGB1C1 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.77; 93.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB1C1 Gene

HapMap Linkage Disequilibrium report
SCGB1C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB1C1 Gene

Disorders for SCGB1C1 Gene

Relevant External Links for SCGB1C1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCGB1C1

No disorders were found for SCGB1C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCGB1C1 Gene

Publications for SCGB1C1 Gene

  1. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 3 67
  2. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PMID: 24026423) Shameer K. … Kullo I.J. (Hum. Genet. 2014) 3
  3. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for SCGB1C1 Gene

Sources for SCGB1C1 Gene

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