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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCGB1A1 Gene

protein-coding GIFtS: 62
GCID: GC11P062188

secretoglobin, family 1A, member 1 (uteroglobin)

(Previous name: uteroglobin )
(Previous symbol: UGB)

Explore 68 diseases affiliated with
SCGB1A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Secretoglobin, Family 1A, Member 1 (Uteroglobin)¹ ²		Urinary Protein 1² ³
CC10¹ ² ³ ⁵		Urine Protein 1² ³
CCSP¹ ² ³ ⁵		CCPBP² ³
UGB¹ ² ³ ⁵		UP-1² ³
CC16¹ ²		UP1² ³
Uteroglobin¹		Blastokinin¹
Clara Cell Phospholipid-Binding Protein² ³		Secretoglobin Family 1A Member 1³
Clara Cells 10 KDa Secretory Protein² ³

External Ids:	HGNC: 12523¹	Entrez Gene: 7356²	Ensembl: ENSG00000149021⁷	OMIM: 192020⁵	UniProtKB: P11684³

Export aliases for SCGB1A1 gene to outside databases

Previous GC identifers: GC11P064700 GC11P063762 GC11P062437 GC11P061961 GC11P061943 GC11P058514

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCGB1A1:

This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been

implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of

hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. (provided by RefSeq, May

2010)

UniProtKB/Swiss-Prot: UTER_HUMAN, P11684

Function: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone,

potent inhibitor of phospholipase A2

Gene Wiki entry for SCGB1A1 (Uteroglobin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SCGB1A1 gene promoter:
SRF RP58 FOXF2 AML1a GATA-3 SRF (504 AA) Nkx6-1 POU2F1 POU2F1a LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCGB1A1 promoter sequence

Search SABiosciences Chromatin IP Primers for SCGB1A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCGB1A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12.3

SCGB1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCGB1A1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P062188: view genomic region (about GC identifiers)

Start:	62,172,575 bp from pter	End:	62,190,678 bp from pter
Size:	18,104 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UTER_HUMAN, P11684 (See protein sequence)

Recommended Name: Uteroglobin precursor

Size: 91 amino acids; 9994 Da

Subunit: Homodimer; antiparallel disulfide-linked

Subcellular location: Secreted

Secondary accessions: B2R5F2 Q6FHH3 Q9UCM2 Q9UCM4

Explore the universe of human proteins at neXtProt for SCGB1A1: NX_P11684

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11684

SCGB1A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003348.1

ENSEMBL proteins:

ENSP00000432866 ENSP00000278282

Human Recombinant Protein Products:

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	Uscn Proteins for SCGB1A1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	IEA	--
GO:0005635	nuclear envelope	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005791	rough endoplasmic reticulum	IEA	--

SCGB1A1 for ontologies About GeneDecksing

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	ThermoFisher Antibodies for SCGB1A1

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	Uscn ELISAs and CLIAs for SCGB1A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SCGB1A1 for domains About GeneDecksing

4 InterPro domains/families:

IPR000329 Uteroglobin-like

IPR016126 Secretoglobin

IPR006038 Uteroglobin-like_superfam

IPR006039 Uteroglobin-like_fam

Graphical View of Domain Structure for InterPro Entry P11684

ProtoNet protein and cluster: P11684

1 Blocks protein family: IPB003628 Uteroglobin subtype

UniProtKB/Swiss-Prot: UTER_HUMAN, P11684

Similarity: Belongs to the secretoglobin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UTER_HUMAN, P11684

Function: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone,

potent inhibitor of phospholipase A2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCGB1A1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate SCGB1A1:
		hsa-miR-143
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for SCGB1A1

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SCGB1A1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019834	phospholipase A2 inhibitor activity	IEA	--

SCGB1A1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SCGB1A1:

Decreased POU5F1-GFP protein e

Animal Models:
Mouse knock-outs for SCGB1A1: Scgb1a1^tm1Brst Scgb1a1^tm1Abm
9 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Scgb1a1):

endocrine/exocrine gland	growth/size	homeostasis/metabolism	immune system	mortality/aging
normal	renal/urinary system	respiratory system	tumorigenesis

SCGB1A1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Prostaglandin Synthesis and Regulation

Prostaglandin Synthesis and Regulation

1.00

FOXA1 transcription factor network

FOXA1 transcription factor network

1.00

Selected targets of C/EBPalpha

Selected targets of C/EBPalpha

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SCGB1A1

Selected targets of C/EBPalpha

2 BioSystems Pathways for SCGB1A1

	Prostaglandin Synthesis and Regulation
	FOXA1 transcription factor network

SCGB1A1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SCGB1A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/7 Interacting proteins for SCGB1A1 (P11684^{2, 3} ENSP00000278282⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FN1	P02751²^,³, ENSP00000346839⁴	MINT-6491137 MINT-6491111 MINT-6491129 I2D: score=2 STRING: ENSP00000346839
LRP2	P98164³, ENSP00000263816⁴	I2D: score=2 STRING: ENSP00000263816
CUBN	O60494³, ENSP00000367064⁴	I2D: score=2 STRING: ENSP00000367064
LMBR1L	Q6UX01³, ENSP00000267102⁴	I2D: score=1 STRING: ENSP00000267102
TRIM32	Q13049³	I2D: score=1

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0007165	signal transduction	NAS	10587371
GO:0007565	female pregnancy	NAS	10587371
GO:0007566	embryo implantation	TAS	10587371
GO:0009410	response to xenobiotic stimulus	IEA	--

SCGB1A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SCGB1A1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SCGB1A1

10/1075 HMDB Compounds for SCGB1A1 (see all 1075) About this table

Compound	Synonyms	CAS #	PubMed Ids
PC(14:0/14:0)	Phosphatidylcholine(14:0/14:0) (see all 8)	--	--
PC(14:0/14:1(9Z))	Phosphatidylcholine(14:0/14:1) (see all 14)	--	--
PC(14:0/15:0)	GPCho(14:0/15:0) (see all 8)	--	--
PC(14:0/16:0)	GPCho(30:0) (see all 8)	--	--
PC(14:0/16:1(9Z))	1-myristoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine (see all 14)	--	--
PC(14:0/18:0)	1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine (see all 8)	--	--
PC(14:0/18:1(11Z))	Phosphatidylcholine(14:0/18:1w7) (see all 14)	--	--
PC(14:0/18:1(9Z))	1-myristoyl-2-oleoyl-sn-glycero-3-phosphocholine (see all 14)	--	--
PC(14:0/18:2(9Z,12Z))	Phosphatidylcholine(32:2) (see all 14)	--	--
PC(14:0/18:3(6Z,9Z,12Z))	GPCho(14:0/18:3w6) (see all 15)	--	--

1 DrugBank Compound for SCGB1A1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL	--	--	target	--	10592235

10/28 Novoseek chemical compound relationships for SCGB1A1 gene (see all 28) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hdmnkvldl	81.6	1	8818992 (1)
progesterone	36.8	42	14735466 (4), 8440203 (4), 2378892 (2), 8050575 (2) (see all 13)
ozone	31	2	15967207 (1), 16963661 (1)
latex	28.4	7	9072037 (1), 19410594 (1), 9517618 (1), 9245950 (1) (see all 7)
gp 130	24.6	4	10494044 (2), 12921923 (1), 9690329 (1)
vitamin a	23.9	7	11193750 (1), 19410594 (1), 11679291 (1), 9245950 (1) (see all 7)
doxycycline	16.7	3	10766812 (1), 16024721 (1), 16055670 (1)
steroid	8.49	9	15813809 (2), 8887668 (1), 15829319 (1), 8050575 (1) (see all 8)
cadmium	6.1	1	2203466 (1)
lipid	4.96	4	16061484 (2), 18172803 (1), 18981578 (1)

Search CenterWatch for drugs/clinical trials and news about SCGB1A1 / UTER

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCGB1A1 gene:

NM_003357.4

Unigene Cluster for SCGB1A1:

Secretoglobin, family 1A, member 1 (uteroglobin)

Hs.523732 [show with all ESTs]

Unigene Representative Sequence: BI819219

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534397 ENST00000278282(uc001ntj.3)

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Additional cDNA sequence:

AK312165.1 BC004481.2 CR541780.1 U01101.1 X13197.1

1 DOTS entry:

DT.113232

24/50 AceView cDNA sequences (see all 50):

CR541780 X13197 BG548246 AA574369 U01101 BG546458 NM_003357 BF222605

BC004481 AA961093 BF810411 BF847674 BG540089 BF847952 BF810409 BM968177

BM998163 T92964 AA569479 BF814645 AA878269 BF810401 BF814633 BF814650

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCGB1A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTGAGTCC

About this image

SCGB1A1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Respiratory Bronchioles

Clara Cells

Selective marker (cell-identifying gene)

Lung

Trachea

Clara Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Lung Epithelial Progenitors (Efficient derivation...)

Lung

Liquid-liquid interface differentiated cells (Derivation of lung e...)

Lung epithelial-like cells (Derivation of lung e...)

Early proximal lung progenitors (Directed differentia...)

See SCGB1A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCGB1A1

SOURCE GeneReport for Unigene cluster: Hs.523732

UniProtKB/Swiss-Prot: UTER_HUMAN, P11684

Tissue specificity: Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways)

SABiosciences Expression via Pathway-Focused PCR Array including SCGB1A1:

Lung Cancer in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SCGB1A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for SCGB1A1 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Scgb1a1^{1 , 5}	secretoglobin, family 1A, member 1 (uteroglobin)^{1, 5}	70.74(n)¹ 55.56(a)¹		19 (6.05 cM)⁵ 22287¹ NM_011681.2¹ NP_035811.1¹ 9083636⁵

ENSEMBL Gene Tree for SCGB1A1 (if available)
TreeFam Gene Tree for SCGB1A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2513033^1,2	C,F,A,	--	58513634(+)	`AGGTCG/AAGTCA`	1	--	us2k¹		5		WA CSA	124
rs41364650^1,2	C,F,	--	58513803(+)	`GAATGG/ACCAGA`	1	--	us2k¹		1		NA	120
rs79251830^1,2		--	58513950(+)	`GGAGCA/TCAGGA`	1	--	us2k¹		0	--	--	--	--
rs41465453^1,2	C,	--	58513965(+)	`AGAGCA/CCTTCT`	1	--	us2k¹		2		CSA WA	120
rs41453645^1,2	C,	--	58514382(+)	`CCAAGC/TGGCCC`	1	--	us2k¹		0	--	--	--	--
rs41439549^1,2	C	--	58514658(+)	`CACCCC/TGGTCA`	2	P L	mis¹		0	--	--	--	--
rs56198430^1,2	C	--	58514780(+)	`CATTCC/TTGCTC`	1	--	int¹		0	--	--	--	--
rs112664306^1,2	C,F,	--	58515092(+)	`TGCTGG/ACAGCT`	1	--	int¹		3		NA	124
rs113487143^1,2		--	58515185(+)	`GAGGAG/ATATTC`	1	--	int¹		1		CSA	2
rs2513034^1,2	C,F,A,H,	--	58515202(+)	`GAGAGC/ATTCCC`	1	--	int¹		9		NS EA WA CSA	536

HapMap Linkage Disequilibrium report for SCGB1A1 (62172575 - 62190678 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCGB1A1: --
Human Gene Mutation Database (HGMD): SCGB1A1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCGB1A1 for disorders           About GeneDecksing

OMIM gene information: 192020
OMIM disorders: 600807
20/68 diseases for SCGB1A1 (see all 68):    About MalaCards

asthma meconium aspiration syndrome vitelliform macular dystrophy bronchiolitis obliterans

congenital diaphragmatic hernia bronchopulmonary dysplasia allergic rhinitis ectopic pregnancy

idiopathic interstitial pneumonia crescentic glomerulonephritis cystic fibrosis macular dystrophy

chronic obstructive pulmonary disease iga glomerulonephritis respiratory failure idiopathic pulmonary fibrosis

cystic fibrosis lung disease glomerulonephritis silicosis rhinitis

3 diseases from the University of Copenhagen DISEASES database for SCGB1A1:

Asthma Vitelliform macular dystrophy IgA glomerulonephritis

10/60 Novoseek disease relationships for SCGB1A1 gene (see all 60) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nephropathy iga	61.3	10	10977777 (3), 11967037 (2), 10716670 (1), 12200800 (1) (see all 7)
bronchoalveolar lavage fluid	58.1	13	14551164 (1), 16215398 (1), 16052892 (1), 16251377 (1) (see all 11)
bronchopulmonary dysplasia	52.9	3	12406855 (1), 18521627 (1), 15774846 (1), 18521628 (1)
asthma	52	75	10619808 (5), 15549500 (4), 16387800 (4), 15467329 (3) (see all 29)
lung diseases	49.4	20	15467329 (5), 14665489 (2), 7541278 (2), 8985135 (2) (see all 9)
respiratory distress syndrome	48.4	4	18521627 (1), 15774846 (1), 11109058 (1)
lung tumor	47.4	5	12826312 (2), 1394139 (1), 9191473 (1)
adenocarcinoma lung	39.7	2	1634515 (1), 16463657 (1)
nasal polyps	39.5	6	15208596 (4), 18702901 (1), 19076932 (1)
atopy	39.3	3	7733299 (1), 9550363 (1), 17716718 (1)

Genetic Association Database (GAD): SCGB1A1
Human Genome Epidemiology (HuGE) Navigator: SCGB1A1 (54 documents)

Export disorders for SCGB1A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SCGB1A1 gene, integrated from 9 sources (see all 344):
(articles sorted by number of sources associating them with SCGB1A1)

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Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. (PubMed id 1284526)^{1, 2, 3, 9} Wolf M.... Suske G. (1992)
Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. (PubMed id 16387800)^{1, 4, 9} Martin A.C....LeSouef P.N. (2006)
Association of an intragenic microsatellite marker in the CC16 gene with asthma in the Indian population. (PubMed id 15549500)^{1, 4, 9} Sharma S. and Ghosh B. (2004)
[Study on association between CC16 gene G38A mutation and asthma in the patients of Han population in Chongqing, China] (PubMed id 14669228)^{1, 4, 9} Gui Q....Li S.P. (2003)
A polymorphism of the CC16 gene is associated with an increased risk of asthma. (PubMed id 9643286)^{1, 4, 9} Laing I.A....Le Souef P.N. (1998)
The Clara cell10 adenine38guanine polymorphism and sarcoidosis susceptibility in Dutch and Japanese subjects. (PubMed id 15297273)^{1, 4, 9} Janssen R....van den Bosch J.M. (2004)
Association between asthma-related phenotypes and the CC16 A38G polymorphism in an unselected population of young adult Danes. (PubMed id 15744536)^{1, 4, 9} Candelaria P.V....Le Souef P.N. (2005)
Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients. (PubMed id 11967037)^{1, 4, 9} Narita I....Gejyo F. (2002)
Evaluation of the -26G>A CC16 polymorphism in acute respiratory distress syndrome. (PubMed id 16215398)^{1, 4, 9} Frerking I....Nickel R. (2005)
Polymorphism of Clara cell 10-kD protein gene of sarcoidosis. (PubMed id 14551164)^{1, 4, 9} Ohchi T....Sato N. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7356	HGNC: 12523	AceView: SCGB1A1	Ensembl:ENSG00000149021	euGenes: HUgn7356
ECgene: SCGB1A1	H-InvDB: SCGB1A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SCGB1A1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SCGB1A1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SCGB1A1 gene
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SCGB1A1 Gene

secretoglobin, family 1A, member 1 (uteroglobin)

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major depression
LUNG TUMOR
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SCGB1A1 Gene

secretoglobin, family 1A, member 1 (uteroglobin)

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