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SCGB1A1 Gene

protein-coding   GIFtS: 63
GCID: GC11P062188

Secretoglobin, Family 1A, Member 1 (Uteroglobin)

(Previous name: uteroglobin)
(Previous symbol: UGB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secretoglobin, Family 1A, Member 1 (Uteroglobin)1 2     Urine Protein 12 3
UGB1 2 3 5     CCPBP2 3
CC102 3 5     UP-12 3
CCSP2 3 5     UP12 3
uteroglobin1 2     Uteroglobin (Clara-Cell Specific 10-KD Protein)1
Clara Cell Phospholipid-Binding Protein2 3     CC162
Clara Cells 10 KDa Secretory Protein2 3     blastokinin2
Urinary Protein 12 3     Secretoglobin Family 1A Member 13

External Ids:    HGNC: 125231   Entrez Gene: 73562   Ensembl: ENSG000001490217   OMIM: 1920205   UniProtKB: P116843   

Export aliases for SCGB1A1 gene to outside databases

Previous GC identifers: GC11P064700 GC11P063762 GC11P062437 GC11P061961 GC11P061943 GC11P058514


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCGB1A1 Gene:
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been
implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering
of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. (provided by RefSeq,
May 2010)

GeneCards Summary for SCGB1A1 Gene:
SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)) is a protein-coding gene. Diseases associated with SCGB1A1 include lung adenoma, and bronchiolitis obliterans. GO annotations related to this gene include phospholipase A2 inhibitor activity.

UniProtKB/Swiss-Prot: UTER_HUMAN, P11684
Function: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly
progesterone, potent inhibitor of phospholipase A2

Gene Wiki entry for SCGB1A1 (Uteroglobin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCGB1A1 gene promoter:
         SRF   RP58   FOXF2   AML1a   GATA-3   SRF (504 AA)   Nkx6-1   POU2F1   POU2F1a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCGB1A1 promoter sequence
   Search Chromatin IP Primers for SCGB1A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCGB1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

SCGB1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCGB1A1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062188:  view genomic region     (about GC identifiers)

Start:
62,172,575 bp from pter      End:
62,190,678 bp from pter
Size:
18,104 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UTER_HUMAN, P11684 (See protein sequence)
Recommended Name: Uteroglobin precursor  
Size: 91 amino acids; 9994 Da
Subunit: Homodimer; antiparallel disulfide-linked
Secondary accessions: B2R5F2 Q6FHH3 Q9UCM2 Q9UCM4

Explore the universe of human proteins at neXtProt for SCGB1A1: NX_P11684

Explore proteomics data for SCGB1A1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SCGB1A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003348.1  
    ENSEMBL proteins: 
     ENSP00000432866   ENSP00000278282  

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    Browse Proteins at Cloud-Clone Corp.

    SCGB1A1 Antibody Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SCGB: Secretoglobins

    2 InterPro protein domains:
     IPR000329 Uteroglobin
     IPR016126 Secretoglobin

    Graphical View of Domain Structure for InterPro Entry P11684

    ProtoNet protein and cluster: P11684

    1 Blocks protein domain: IPB003628 Uteroglobin subtype

    UniProtKB/Swiss-Prot: UTER_HUMAN, P11684
    Similarity: Belongs to the secretoglobin family


    SCGB1A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UTER_HUMAN, P11684
    Function: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly
    progesterone, potent inhibitor of phospholipase A2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI18243143
    GO:0019834phospholipase A2 inhibitor activity IEA--
         
    SCGB1A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SCGB1A1:
     Decreased POU5F1-GFP protein e 

         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Scgb1a1):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  immune system  mortality/aging 
     normal  renal/urinary system  respiratory system  tumorigenesis 

    SCGB1A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SCGB1A1: Scgb1a1tm1Brst Scgb1a1tm1Abm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCGB1A1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCGB1A1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCGB1A1

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SCGB1A1:
    hsa-miR-143
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Sino Biological Human cDNA Clone for SCGB1A1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCGB1A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UTER_HUMAN, P11684: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    endoplasmic reticulum2
    nucleus2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005622intracellular ----
    GO:0005635nuclear envelope IEA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum ----

    SCGB1A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SCGB1A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of C EBPalpha
    Selected targets of C EBPalpha
    2Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation
    3FOXA1 transcription factor network
    FOXA1 transcription factor network


    2 BioSystems Pathways for SCGB1A1
        Prostaglandin Synthesis and Regulation
    FOXA1 transcription factor network



        Pathway & Disease-focused RT2 Profiler PCR Array including SCGB1A1: 
              Lung Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SCGB1A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SCGB1A1 (P116841, 2, 3 ENSP000002782824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027511, 2, 3, ENSP000003468394EBI-7797649,EBI-1220319 MINT-6491137 MINT-6491111 MINT-6491129 I2D: score=2 STRING: ENSP00000346839
    LRP2P981643, ENSP000002638164I2D: score=2 STRING: ENSP00000263816
    CUBNO604943, ENSP000003670644I2D: score=2 STRING: ENSP00000367064
    LMBR1LQ6UX013, ENSP000002671024I2D: score=1 STRING: ENSP00000267102
    TRIM32Q130493I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007165signal transduction NAS10587371
    GO:0007565female pregnancy NAS10587371
    GO:0007566embryo implantation TAS10587371
    GO:0009410response to xenobiotic stimulus IEA--

    SCGB1A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCGB1A1 (UTER)

    Selected HMDB Compounds for SCGB1A1 (see all 1075)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(14:0/14:0)Phosphatidylcholine(14:0/14:0) (see all 8)----
    PC(14:0/14:1(9Z))Phosphatidylcholine(14:0/14:1) (see all 14)----
    PC(14:0/15:0)GPCho(14:0/15:0) (see all 8)----
    PC(14:0/16:0)GPCho(30:0) (see all 8)----
    PC(14:0/16:1(9Z))1-myristoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine (see all 14)----
    PC(14:0/18:0)1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine (see all 8)----
    PC(14:0/18:1(11Z))Phosphatidylcholine(14:0/18:1w7) (see all 14)----
    PC(14:0/18:1(9Z))1-myristoyl-2-oleoyl-sn-glycero-3-phosphocholine (see all 14)----
    PC(14:0/18:2(9Z,12Z))Phosphatidylcholine(32:2) (see all 14)----
    PC(14:0/18:3(6Z,9Z,12Z))GPCho(14:0/18:3w6) (see all 15)----

    1 DrugBank Compound for SCGB1A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for SCGB1A1 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hdmnkvldl 81.6 1 8818992 (1)
    progesterone 36.8 42 14735466 (4), 8440203 (4), 2378892 (2), 8050575 (2) (see all 13)
    ozone 31 2 15967207 (1), 16963661 (1)
    latex 28.4 7 9072037 (1), 19410594 (1), 9517618 (1), 9245950 (1) (see all 7)
    gp 130 24.6 4 10494044 (2), 12921923 (1), 9690329 (1)
    vitamin a 23.9 7 11193750 (1), 19410594 (1), 11679291 (1), 9245950 (1) (see all 7)
    doxycycline 16.7 3 10766812 (1), 16024721 (1), 16055670 (1)
    steroid 8.49 9 15813809 (2), 8887668 (1), 15829319 (1), 8050575 (1) (see all 8)
    cadmium 6.1 1 2203466 (1)
    lipid 4.96 4 16061484 (2), 18172803 (1), 18981578 (1)



    SCGB1A1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SCGB1A1 gene: 
    NM_003357.4  

    Unigene Cluster for SCGB1A1:

    Secretoglobin, family 1A, member 1 (uteroglobin)
    Hs.523732  [show with all ESTs]
    Unigene Representative Sequence: BI819219
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534397 ENST00000278282(uc001ntj.3)
    miRNA
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    Additional mRNA sequence: 

    AK312165.1 BC004481.2 CR541780.1 U01101.1 X13197.1 

    1 DOTS entry:

    DT.113232 

    Selected AceView cDNA sequences (see all 50):

    X13197 CR541780 BG546458 BC004481 NM_003357 BG548246 AA961093 U01101 
    BF222605 AA574369 T92964 BF847674 BM998163 BF810411 BG540089 BM968177 
    BF810409 BF847952 BF814650 BF810401 AA569479 BF814639 AA878269 BX282306 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCGB1A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGAGTCC
    SCGB1A1 Expression
    About this image


    SCGB1A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Lung (Respiratory System)    fully expand to see all 8 entries
             Clara Cells Trachea
             Liquid-liquid interface differentiated cells
             bronchus ; respiratory epithelial cells   
             Trachea   
     
     Epithelial Cells
             Clara Cells Respiratory Bronchioles
             bronchus ; respiratory epithelial cells   
             nasal epithelium   
     
     Respiratory System (Respiratory System)
             bronchial epithelia   
     
     Nose (Sensory Organs)
             nasal epithelium   
    SCGB1A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCGB1A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523732

    UniProtKB/Swiss-Prot: UTER_HUMAN, P11684
    Tissue specificity: Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways)

        Pathway & Disease-focused RT2 Profiler PCR Array including SCGB1A1: 
              Lung Cancer in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCGB1A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SCGB1A1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scgb1a11 , 5 secretoglobin, family 1A, member 1 (uteroglobin)1, 5 70.74(n)1
    55.56(a)1
      19 (6.05 cM)5
    222871  NM_011681.21  NP_035811.11 
     90836365 


    ENSEMBL Gene Tree for SCGB1A1 (if available)
    TreeFam Gene Tree for SCGB1A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCGB1A1 gene
    1 SIMAP similar gene for SCGB1A1 using alignment to 2 protein entries:     UTER_HUMAN (see all proteins):
    SCGB1C1

    SCGB1A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCGB1A1 (see all 158)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840981741,2
    C--62104799(+) AGAACA/GAGGCC 1 -- us2k10--------
    rs1141988521,2
    C--62104850(+) GCAACC/GCTTTC 1 -- us2k10--------
    rs1884899841,2
    --62104855(+) CCTTTC/TGAAGC 1 -- us2k10--------
    rs1816908681,2
    --62104938(+) GGAGTA/GCAATG 1 -- us2k10--------
    rs1841751001,2
    --62104986(+) TTCAAA/GCAATT 1 -- us2k10--------
    rs1906711031,2
    C--62105074(+) GAGACA/GGGGTT 1 -- us2k10--------
    rs414383481,2
    C--62105207(+) TTTTTA/TTTTAT 1 -- us2k10--------
    rs413727461,2
    C,F--62105245(+) TGCCAC/TGCAAT 1 -- us2k10--------
    rs1416633801,2
    --62105499(+) GGCTAA/CGTCGT 1 -- us2k10--------
    rs25130331,2
    C,F,A--62105715(+) AGGTCG/AAGTCA 1 -- us2k15Minor allele frequency- A:0.29WA CSA 124

    HapMap Linkage Disequilibrium report for SCGB1A1 (62172575 - 62190678 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SCGB1A1: --
    Human Gene Mutation Database (HGMD): SCGB1A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCGB1A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SCGB1A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 192020   
    OMIM disorders: 600807  
    Selected diseases for SCGB1A1 (see all 65):    
    About MalaCards
    lung adenoma    bronchiolitis obliterans    silicosis    bronchopulmonary dysplasia
    crescentic glomerulonephritis    asthma    bronchiolitis    iga glomerulonephritis
    meconium aspiration syndrome    pulmonary disease, chronic obstructive    pulmonary edema    idiopathic interstitial pneumonia
    respiratory failure    pneumoconiosis    congenital diaphragmatic hernia    pulmonary sarcoidosis
    vitelliform macular dystrophy    allergic rhinitis    ectopic pregnancy    pneumonia

    4 diseases from the University of Copenhagen DISEASES database for SCGB1A1:
    Asthma     Vitelliform macular dystrophy     IgA glomerulonephritis     Allergic rhinitis

    SCGB1A1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SCGB1A1 gene (see all 60)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nephropathy iga 61.3 10 10977777 (3), 11967037 (2), 10716670 (1), 12200800 (1) (see all 7)
    bronchoalveolar lavage fluid 58.1 13 14551164 (1), 16215398 (1), 16052892 (1), 16251377 (1) (see all 11)
    bronchopulmonary dysplasia 52.9 3 12406855 (1), 18521627 (1), 15774846 (1), 18521628 (1)
    asthma 52 75 10619808 (5), 15549500 (4), 16387800 (4), 15467329 (3) (see all 29)
    lung diseases 49.4 20 15467329 (5), 14665489 (2), 7541278 (2), 8985135 (2) (see all 9)
    respiratory distress syndrome 48.4 4 18521627 (1), 15774846 (1), 11109058 (1)
    lung tumor 47.4 5 12826312 (2), 1394139 (1), 9191473 (1)
    adenocarcinoma lung 39.7 2 1634515 (1), 16463657 (1)
    nasal polyps 39.5 6 15208596 (4), 18702901 (1), 19076932 (1)
    atopy 39.3 3 7733299 (1), 9550363 (1), 17716718 (1)

    Genetic Association Database (GAD): SCGB1A1
    Human Genome Epidemiology (HuGE) Navigator: SCGB1A1 (54 documents)

    Export disorders for SCGB1A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SCGB1A1 gene, integrated from 10 sources (see all 355):
    (articles sorted by number of sources associating them with SCGB1A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. (PubMed id 1284526)1, 2, 3, 9 Wolf M.... Suske G. (Hum. Mol. Genet. 1992)
    2. Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. (PubMed id 16387800)1, 4, 9 Martin A.C....LeSouAf P.N. (Am. J. Respir. Crit. Care Med. 2006)
    3. Association of an intragenic microsatellite marker in the CC16 gene with asthma in the Indian population. (PubMed id 15549500)1, 4, 9 Sharma S. and Ghosh B. (J. Hum. Genet. 2004)
    4. Cross-sectional and longitudinal association of the secretoglobin 1A1 gene A38G polymorphism with asthma phenotype in the Perth Infant Asthma Follow-up cohort. (PubMed id 19128353)1, 4, 9 Laing I.A....Le SouAf P.N. (Clin. Exp. Allergy 2009)
    5. [Study on association between CC16 gene G38A mutation and asthma in the patients of Han population in Chongqing, China]. (PubMed id 14669228)1, 4, 9 Gui Q....Li S.P. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003)
    6. A polymorphism of the CC16 gene is associated with an increased risk of asthma. (PubMed id 9643286)1, 4, 9 Laing I.A....Le SouAf P.N. (J. Med. Genet. 1998)
    7. Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. (PubMed id 17716718)1, 4, 9 Yang K.D....Huang S.K. (J. Allergy Clin. Immunol. 2007)
    8. No association between the Clara cell secretory protein (CC16) gene polymorphism and personality traits. (PubMed id 16764982)1, 4, 9 Tochigi M....Sasaki T. (amp 2006)
    9. The Clara cell10 adenine38guanine polymorphism and sarcoidosis susceptibility in Dutch and Japanese subjects. (PubMed id 15297273)1, 4, 9 Janssen R....van den Bosch J.M. (Am. J. Respir. Crit. Care Med. 2004)
    10. Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy. (PubMed id 19222419)1, 4, 9 Zhang G....Le SouAf P.N. (Allergy 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 7356 HGNC: 12523 AceView: SCGB1A1 Ensembl:ENSG00000149021 euGenes: HUgn7356
    ECgene: SCGB1A1 H-InvDB: SCGB1A1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SCGB1A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SCGB1A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SCGB1A1 gene:
    Search GeneIP for patents involving SCGB1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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