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Aliases for SCG5 Gene

Aliases for SCG5 Gene

  • Secretogranin V 2 3 4
  • SGNE1 3 4 6
  • Secretory Granule, Neuroendocrine Protein 1 (7B2 Protein) 2 3
  • Secretory Granule Endocrine Protein I 3 4
  • Prohormone Convertase Chaperone 2 3
  • Pituitary Polypeptide 3 4
  • Secretogranin-5 3 4
  • Secretogranin V (7B2 Protein) 3
  • Neuroendocrine Protein 7B2 3
  • P7B2 3
  • 7B2 3
  • SgV 3

External Ids for SCG5 Gene

Previous Symbols for SCG5 Gene

  • SGNE1

Summaries for SCG5 Gene

GeneCards Summary for SCG5 Gene

SCG5 (Secretogranin V) is a Protein Coding gene. Diseases associated with SCG5 include hereditary mixed polyposis syndrome 1 and hereditary mixed polyposis syndrome. GO annotations related to this gene include GTP binding and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for SCG5 Gene

  • Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Gene Wiki entry for SCG5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCG5 Gene

Genomics for SCG5 Gene

Genomic Location for SCG5 Gene

Start:
32,641,669 bp from pter
End:
32,697,098 bp from pter
Size:
55,430 bases
Orientation:
Plus strand

Genomic View for SCG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCG5 Gene

Regulatory Elements for SCG5 Gene

Proteins for SCG5 Gene

  • Protein details for SCG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05408-7B2_HUMAN
    Recommended name:
    Neuroendocrine protein 7B2
    Protein Accession:
    P05408
    Secondary Accessions:
    • P01164
    • Q6FHD0
    • Q9BS38

    Protein attributes for SCG5 Gene

    Size:
    212 amino acids
    Molecular mass:
    23730 Da
    Quaternary structure:
    • Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.

    Alternative splice isoforms for SCG5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCG5 Gene

Proteomics data for SCG5 Gene at MOPED

Post-translational modifications for SCG5 Gene

  • Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.
  • Sulfated on tyrosine residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCG5 Gene

No data available for DME Specific Peptides for SCG5 Gene

Domains for SCG5 Gene

Protein Domains for SCG5 Gene

UniProtKB/Swiss-Prot:

7B2_HUMAN
Family:
  • Belongs to the 7B2 family.:
    • P05408
genes like me logo Genes that share domains with SCG5: view

No data available for Gene Families for SCG5 Gene

Function for SCG5 Gene

Molecular function for SCG5 Gene

UniProtKB/Swiss-Prot Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Gene Ontology (GO) - Molecular Function for SCG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity ISS --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding TAS 3134253
GO:0051082 unfolded protein binding IDA 7913882
genes like me logo Genes that share ontologies with SCG5: view
genes like me logo Genes that share phenotypes with SCG5: view

Animal Models for SCG5 Gene

MGI Knock Outs for SCG5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SCG5 Gene

Localization for SCG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCG5 Gene

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCG5 Gene COMPARTMENTS Subcellular localization image for SCG5 gene
Compartment Confidence
extracellular 5
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SCG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030141 secretory granule ISS --
genes like me logo Genes that share ontologies with SCG5: view

Pathways for SCG5 Gene

SuperPathways for SCG5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport ISS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0016486 peptide hormone processing ISS --
GO:0043086 negative regulation of catalytic activity IEA --
GO:0046883 regulation of hormone secretion ISS --
genes like me logo Genes that share ontologies with SCG5: view

No data available for Pathways by source for SCG5 Gene

Compounds for SCG5 Gene

(59) Novoseek inferred chemical compound relationships for SCG5 Gene

Compound -log(P) Hits PubMed IDs
trimethylsilylisothiocyanate 78.8 1
aitc 45.2 1
metarhodopsin ii 43.7 5
proglucagon 41.8 3
aerolysin 40.9 1
genes like me logo Genes that share compounds with SCG5: view

Transcripts for SCG5 Gene

Unigene Clusters for SCG5 Gene

Secretogranin V (7B2 protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCG5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7:

Relevant External Links for SCG5 Gene

GeneLoc Exon Structure for
SCG5
ECgene alternative splicing isoforms for
SCG5

Expression for SCG5 Gene

mRNA expression in normal human tissues for SCG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCG5 Gene

This gene is overexpressed in Pituitary (6.7), Brain - Frontal Cortex (BA9) (4.9), Brain - Anterior cingulate cortex (BA24) (4.3), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCG5 Gene

SOURCE GeneReport for Unigene cluster for SCG5 Gene Hs.156540

genes like me logo Genes that share expressions with SCG5: view

Orthologs for SCG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCG5 36
  • 99.37 (n)
  • 100 (a)
SCG5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCG5 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCG5 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scg5 36
  • 87.74 (n)
  • 91.98 (a)
Scg5 16
Scg5 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCG5 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCG5 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scg5 36
  • 87.3 (n)
  • 92.38 (a)
chicken
(Gallus gallus)
Aves SCG5 36
  • 75.67 (n)
  • 81.99 (a)
SCG5 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCG5 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397865 36
tropical clawed frog
(Silurana tropicalis)
Amphibia scg5 36
  • 73.13 (n)
  • 81.63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9417 36
zebrafish
(Danio rerio)
Actinopterygii scg5 36
  • 70.24 (n)
  • 78.54 (a)
scg5 37
  • 73 (a)
OneToMany
scg5 37
  • 73 (a)
OneToMany
zgc73132 36
Species with no ortholog for SCG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCG5 Gene

ENSEMBL:
Gene Tree for SCG5 (if available)
TreeFam:
Gene Tree for SCG5 (if available)

Paralogs for SCG5 Gene

No data available for Paralogs for SCG5 Gene

Variants for SCG5 Gene

Sequence variations from dbSNP and Humsavar for SCG5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs13850 -- 32,641,754(-) CCTAC(A/T)GCGGT utr-variant-5-prime
rs1406387 -- 32,666,510(-) TGTTC(A/G)TTTCT intron-variant
rs1406388 -- 32,695,895(-) AAAGA(A/T)GTGCA intron-variant
rs1881536 -- 32,678,349(-) CAATT(C/T)GTATG intron-variant
rs1997316 -- 32,693,786(-) GCACT(G/T)CTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCG5 Gene

Variant ID Type Subtype PubMed ID
dgv723e1 CNV Complex 17122850
nsv428302 CNV Gain+Loss 18775914
esv33337 CNV Gain+Loss 17666407
nsv517740 CNV Gain+Loss 19592680
dgv728e1 CNV Complex 17122850
dgv729e1 CNV Complex 17122850
esv2422296 CNV Duplication 17116639
nsv469587 CNV Loss 16826518
nsv483039 CNV Gain 15286789
nsv456785 CNV Gain 19166990
nsv1481 CNV Loss 18451855
esv271798 CNV Insertion 20981092

Relevant External Links for SCG5 Gene

HapMap Linkage Disequilibrium report
SCG5

Disorders for SCG5 Gene

(41) Novoseek inferred disease relationships for SCG5 Gene

Disease -log(P) Hits PubMed IDs
acth syndrome ectopic 31.5 3
glucagonoma 24.9 1
cataplexy 18.7 1
carcinoid 16.3 4
autoimmune response 15.8 2

Relevant External Links for SCG5

Genetic Association Database (GAD)
SCG5
Human Genome Epidemiology (HuGE) Navigator
SCG5
genes like me logo Genes that share disorders with SCG5: view

No data available for UniProtKB/Swiss-Prot for SCG5 Gene

Publications for SCG5 Gene

  1. Structural organization of the gene encoding the neuroendocrine chaperone 7B2. (PMID: 8617287) Braks J.A. … Martens G.J.M. (Eur. J. Biochem. 1996) 3 4 23
  2. Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas. (PMID: 8162254) Lloyd R.V. … Jin L. (Diagn. Mol. Pathol. 1994) 2 3 23
  3. Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity. (PMID: 17617923) Bouatia-Naji N. … Meyre D. (BMC Med. Genet. 2007) 3 23 49
  4. 7B2 is a specific intracellular binding protein of the prohormone convertase PC2. (PMID: 7722516) Benjannet S. … Seidah N.G. (J. Neurochem. 1995) 3 23
  5. SGNE1/7B2 is epigenetically altered and transcriptionally downregulated in human medulloblastomas. (PMID: 17334394) Waha A. … Waha A. (Oncogene 2007) 3 23

Products for SCG5 Gene

Sources for SCG5 Gene

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