Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCG5 Gene

protein-coding   GIFtS: 56
GCID: GC15P032933

Secretogranin V (7B2 Protein)

(Previous names: secretory granule, neuroendocrine protein 1 (7B2 protein))
(Previous symbol: SGNE1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Secretogranin V (7B2 Protein)1 2     P7B22
SGNE11 2 3 5     SgV2
Secretory Granule, Neuroendocrine Protein 1 (7B2 Protein)1 2     Neuroendocrine Protein 7B22
Prohormone Convertase Chaperone1 2     secretogranin-52
Pituitary Polypeptide2 3     Secretogranin-53
Secretory Granule Endocrine Protein I2 3     Secretogranin V3
7B22     

External Ids:    HGNC: 108161   Entrez Gene: 64472   Ensembl: ENSG000001669227   OMIM: 1731205   UniProtKB: P054083   

Export aliases for SCG5 gene to outside databases

Previous GC identifers: GC15P030722 GC15P009796


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SCG5 Gene: 
SCG5 (secretogranin V (7B2 protein)) is a protein-coding gene. Diseases associated with SCG5 include xanthogranulomatous pyelonephritis, and glucagonoma. GO annotations related to this gene include enzyme inhibitor activity and GTP binding.

UniProtKB/Swiss-Prot: 7B2_HUMAN, P05408
Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated
secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there
to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required
for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary
hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro

Gene Wiki entry for SCG5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCG5 gene promoter:
         c-Fos   AP-1   ATF-2   Lmo2   LUN-1   CUTL1   c-Jun   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCG5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCG5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13-q14   Ensembl cytogenetic band:  15q13.3   HGNC cytogenetic band: 15q13-q14

SCG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCG5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P032933:  view genomic region     (about GC identifiers)

Start:
32,933,870 bp from pter      End:
32,989,299 bp from pter
Size:
55,430 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 7B2_HUMAN, P05408 (See protein sequence)
Recommended Name: Neuroendocrine protein 7B2 precursor  
Size: 212 amino acids; 23730 Da
Subunit: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages
Subcellular location: Secreted. Note=Neuroendocrine and endocrine secretory granules
Secondary accessions: P01164 Q9BS38
Alternative splicing: 2 isoforms:  P05408-1   P05408-2   

Explore the universe of human proteins at neXtProt for SCG5: NX_P05408

Explore proteomics data for SCG5 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides (By similarity)
  • UniProtKB: Sulfated on tyrosine residues (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05408

  • SCG5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCG5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138229.1  NP_003011.1  

    ENSEMBL proteins: 
     ENSP00000300175   ENSP00000388560   ENSP00000418430   ENSP00000420347   ENSP00000418485  

    Human Recombinant Protein Products for SCG5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for SCG5
    OriGene Protein Over-expression Lysate for SCG5
    OriGene MassSpec for SCG5 
    OriGene Custom Protein Services for SCG5
    GenScript Custom Purified and Recombinant Proteins Services for SCG5
    Novus Biologicals SCG5 Proteins
    Novus Biologicals SCG5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SCG5
    Cloud-Clone Corp. Proteins for SCG5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030141secretory granule ISS--

    SCG5 for ontologies           About GeneDecksing



    SCG5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SCG5
    GenScript Custom Superior Antibodies Services for SCG5
    Novus Biologicals SCG5 Antibodies
    Abcam antibodies for SCG5
    Cloud-Clone Corp. Antibodies for SCG5 
    ThermoFisher Antibodies for SCG5
    LSBio Antibodies in human, mouse, rat for SCG5 

    Assay Products for SCG5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SCG5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCG5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCG5 
    Cloud-Clone Corp. CLIAs for SCG5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007945 Secretogranin_V

    Graphical View of Domain Structure for InterPro Entry P05408

    ProtoNet protein and cluster: P05408

    1 Blocks protein domain: IPB007945 Neuroendocrine 7B2 precursor

    UniProtKB/Swiss-Prot: 7B2_HUMAN, P05408
    Similarity: Belongs to the 7B2 family


    SCG5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 7B2_HUMAN, P05408
    Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated
    secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there
    to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required
    for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary
    hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ISS--
    GO:0005515protein binding IPI7913882
    GO:0005525GTP binding TAS3134253
    GO:0051082unfolded protein binding IDA7913882
         
    SCG5 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Scg5):
     adipose tissue  behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  nervous system  reproductive system  respiratory system 

    SCG5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Scg5tm1Led for SCG5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCG5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCG5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCG5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCG5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCG5
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SCG5:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidSCG5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCG5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCG5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCG5
    Sirion Biotech Customized adenovirus for overexpression of SCG5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SCG5 (see all 13)
    OriGene ORF clones in mouse, rat for SCG5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCG5 (NM_003020)
    Sino Biological Human cDNA Clone for SCG5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCG5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCG5
    Sirion Biotech Customized lentivirus for stable overexpression of SCG5 
                         Customized lentivirus expression plasmids for stable overexpression of SCG5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SCG5
    Search LifeMap BioReagents cell lines for SCG5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCG5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCG5

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for SCG5 (P054082, 3 ENSP000003001754) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2863095 I2D: score=6 STRING: ENSP00000357292
    PCSK2P165193, ENSP000002625454I2D: score=2 STRING: ENSP00000262545
    PSTPIP1O435863, ENSP000003689144I2D: score=1 STRING: ENSP00000368914
    NR1H2P550553I2D: score=1 
    KHDRBS1ENSP000003138294STRING: ENSP00000313829
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ISS--
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0016486peptide hormone processing ISS--
    GO:0043086negative regulation of catalytic activity ----
    GO:0046883regulation of hormone secretion ISS--

    SCG5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCG5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCG5 (7B2)

    10/59 Novoseek inferred chemical compound relationships for SCG5 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trimethylsilylisothiocyanate 78.8 1 11846383 (1)
    aitc 45.2 1 9324956 (1)
    metarhodopsin ii 43.7 9 10220390 (2), 10812086 (2), 17014882 (1)
    proglucagon 41.8 3 19223471 (2), 1678563 (1)
    aerolysin 40.9 1 1382579 (1)
    hirudin 33.4 7 9716158 (1), 7832783 (1), 2107100 (1), 8457193 (1) (see all 6)
    serine 32.7 5 8216207 (1), 9645470 (1), 9399575 (1), 17258834 (1) (see all 5)
    cyanogen bromide 28.3 1 1619632 (1)
    ctp 25.7 2 16122898 (1), 11018759 (1)
    phosphotyrosine 24.4 3 10543978 (1), 11746693 (1)

    Search CenterWatch for drugs/clinical trials and news about SCG5 / 7B2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCG5 gene (2 alternative transcripts): 
    NM_001144757.1  NM_003020.3  

    Unigene Cluster for SCG5:

    Secretogranin V (7B2 protein)
    Hs.156540  [show with all ESTs]
    Unigene Representative Sequence: BU570828
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300175(uc001zha.2) ENST00000413748(uc001zgz.2) ENST00000494364
    ENST00000497208 ENST00000471027 ENST00000470349 ENST00000498069 ENST00000498607
    ENST00000475752

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCG5
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SCG5:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidSCG5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCG5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCG5
    Clone
    Products:
         
    OriGene clones in human, mouse for SCG5 (see all 13)
    OriGene ORF clones in mouse, rat for SCG5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCG5 (NM_003020)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCG5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCG5
    Sirion Biotech Customized lentivirus for stable overexpression of SCG5 
                         Customized lentivirus expression plasmids for stable overexpression of SCG5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SCG5
    OriGene qSTAR qPCR primer pairs in human, mouse for SCG5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCG5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCG5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCG5

    Additional mRNA sequence: 

    AK314965.1 BC005349.1 BC093053.1 CR541824.1 Y00757.1 

    12 DOTS entries:

    DT.100797562  DT.100797565  DT.100033593  DT.100797561  DT.97826920  DT.100726492  DT.99998701  DT.102829511 
    DT.100797564  DT.121080873  DT.91755963  DT.95149607 

    24/519 AceView cDNA sequences (see all 519):

    AA364943 BM352436 BM508249 BQ776917 AA364050 BQ788007 T15926 BM352402 
    BM310566 BU072018 Y00757 CA942119 BM509988 BU073367 BQ286100 BQ270664 
    BI711459 CA950021 BM508069 BG656512 BQ632091 BM310215 CA947144 BM509203 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SCG5 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
    SP1:                                      -     -                 -     -                                 
    SP2:                                      -     -                 -     -                                 
    SP3:                                      -     -           -     -     -                                 
    SP4:                                      -     -           -     -     -                                 
    SP5:                                      -     -                                                         


    ECgene alternative splicing isoforms for SCG5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCG5 expression in normal human tissues (normalized intensities)      SCG5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCAAGCA
    SCG5 Expression
    About this image


    SCG5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Pons
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
             Globus Pallidus   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 5 entries
             Human Schwann Cells (HSC)   
             autonomic/sympathetic/ganglion   
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem Progenitor EN7
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Islets of Langerhans
             Pancreatic Islet   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Midgut

    See SCG5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCG5

    SOURCE GeneReport for Unigene cluster: Hs.156540
        SABiosciences Custom PCR Arrays for SCG5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SCG5
    OriGene qSTAR qPCR primer pairs in human, mouse for SCG5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCG5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCG5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCG5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCG5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SCG5 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scg55 secretogranin V   --   2 (57.45 cM) 113776362 
    chicken
    (Gallus gallus)
    Aves SCG51 secretogranin V (7B2 protein) 75.87(n)
    82.38(a)
      769742  XM_001233026.2  XP_001233027.2 
    lizard
    (Anolis carolinensis)
    Reptilia SCG56
    Uncharacterized protein
    82(a)
    1 ↔ 1
    1(32823194-32856163)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978652 X. laevis mRNA for 7B2 pituitary protein, partial cds 76.94(n)    X15608.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731322 hypothetical protein MGC73132 76.91(n)   393699  BC059495.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 7B26
    7B2
    22(a)
    1 ↔ 1
    3R(1202476-1203701)
    worm
    (Caenorhabditis elegans)
    Secernentea sbt-16
    Protein SBT-1
    25(a)
    1 ↔ 1
    V(20827715-20828886)


    ENSEMBL Gene Tree for SCG5 (if available)
    TreeFam Gene Tree for SCG5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCG5 gene
    1 SIMAP similar gene for SCG5 using alignment to 4 protein entries:     7B2_HUMAN (see all proteins):
    SGNE1

    SCG5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1178 SNPs in SCG5 are shown (see all 1178)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs577898561,2
    --32932391(+) GCACAA/GTCTCA 2 -- us2k10--------
    rs1171857981,2
    F--32932516(+) GATACG/AGGATT 2 -- us2k11Minor allele frequency- A:0.02NA 120
    rs80371021,2
    C,F,A,H--32932650(+) TATGAG/AGTTTT 2 -- us2k1 tfbs328Minor allele frequency- A:0.27NS EA NA WA CSA 2476
    rs1846124311,2
    --32932767(+) AAAATA/GAAGAT 2 -- us2k10--------
    rs1165335891,2
    C,F--32932776(+) ATAACA/GATGAA 2 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1886322901,2
    --32932937(+) ATGAGC/TATCCG 2 -- us2k10--------
    rs787915921,2
    C,F--32933026(+) CTATTT/CATTGC 2 -- us2k11Minor allele frequency- C:0.17WA 118
    rs1812945791,2
    --32933092(+) TCTGGA/GTTCTA 2 -- us2k10--------
    rs1169813571,2
    C--32933363(+) GTGGAC/AGTTTA 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1500468511,2
    --32933368(+) CGTTTA/GGAAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCG5 (32933870 - 32989299 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for SCG5 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422296CNV Duplication17116639
    esv271798CNV Insertion20981092
    nsv1481CNV Loss18451855
    nsv469587CNV Loss16826518
    nsv483039CNV Gain15286789
    nsv456785CNV Gain19166990
    nsv517740CNV Gain+Loss19592680
    esv33337CNV Gain+Loss17666407
    nsv428302CNV Gain+Loss18775914
    dgv728e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SCG5
    DNA2.0 Custom Variant and Variant Library Synthesis for SCG5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 173120    OMIM disorders: --

    20/44 diseases for SCG5 (see all 44):    About MalaCards
    xanthogranulomatous pyelonephritis    glucagonoma    wolfram syndrome    pyelonephritis
    myasthenia gravis    adrenoleukodystrophy    insulinoma    ehlers-danlos syndrome
    brain ischemia    diabetes insipidus    narcolepsy    duodenal ulcer
    duodenitis    pituitary tumors    acromegaly    ependymoma
    glucose intolerance    medulloblastoma    stomatitis    herpes simplex


    SCG5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/41 Novoseek inferred disease relationships for SCG5 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth syndrome ectopic 31.5 3 1752059 (2), 1424185 (1)
    glucagonoma 24.9 1 7517367 (1)
    cataplexy 18.7 1 16171287 (1)
    carcinoid 16.3 6 1752059 (2), 1424185 (1), 1674253 (1)
    autoimmune response 15.8 2 19473527 (1), 12571858 (1)
    insulinoma 15.7 8 9870681 (2), 7517367 (2), 1709861 (1)
    adrenoleukodystrophy 12.8 2 8002973 (1)
    metastasis 5.07 1 9083150 (1)
    colorectal cancer 4.42 1 16293189 (1)
    asthma 3.21 1 14713911 (1)

    Genetic Association Database (GAD): SCG5
    Human Genome Epidemiology (HuGE) Navigator: SCG5 (4 documents)

    Export disorders for SCG5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCG5 gene, integrated from 9 sources (see all 317):
    (articles sorted by number of sources associating them with SCG5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity. (PubMed id 17617923)1, 4, 9 Bouatia-Naji N....Meyre D. (2007)
    2. Structural organization of the gene encoding the neuroendocrine chaperone 7B2. (PubMed id 8617287)1, 2, 9 Braks J.A.... Martens G.J. (1996)
    3. Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas. (PubMed id 8162254)1, 3, 9 Lloyd R.V. and Jin L. (1994)
    4. Meta-analysis of new genome-wide association studies o f colorectal cancer risk. (PubMed id 21761138)1, 4 Peters U....Casey G. (2012)
    5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The chromogranin-secretogranin family. (PubMed id 12646671)1, 3 Taupenot L....O'Connor D.T. (2003)
    8. Neuroendocrine secretory protein 7B2: structure, expression and functions. (PubMed id 11439082)1, 2 Mbikay M.... Chretien M. (2001)
    9. 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway. (PubMed id 7913882)1, 2 Braks J.A. and Martens G.J.M. (1994)
    10. The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man. (PubMed id 1989596)1, 2 Paquet L.... Mbikay M. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6447 HGNC: 10816 AceView: SGNE1 Ensembl:ENSG00000166922 euGenes: HUgn6447
    ECgene: SCG5 H-InvDB: SCG5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCG5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCG5 gene:
    Search GeneIP for patents involving SCG5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SCG5  
     OriGene qPCR primer pairs and template standards for SCG5   OriGene Protein Over-expression Lysate for SCG5  
     OriGene MassSpec something-or-other for SCG5   OriGene clones in human, mouse for SCG5  
     OriGene qSTAR qPCR primer pairs in human, mouse for SCG5   OriGene Purified Protein for SCG5  
     OriGene ORF clones in mouse, rat for SCG5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCG5   OriGene Custom Protein Services for SCG5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCG5
     QIAGEN SeqTarget long-range PCR primers for resequencing SCG5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCG5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCG5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCG5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCG5
     GenScript Custom Purified and Recombinant Proteins Services for SCG5 GenScript cDNA clones with any tag delivered in your preferred vector for SCG5
     GenScript Custom Assay Services for SCG5 GenScript Custom Superior Antibodies Services for SCG5
     GenScript Custom overexpressing Cell Line Services for SCG5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SCG5 promoter
     Search Chromatin IP Primers for SCG5
     RT2 qPCR Primer Assay in human, mouse, rat SCG5
     GNC Network for SCG5
     SABiosciences Custom PCR Arrays for SCG5
     Search Tocris compounds for SCG5 (7B2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SCG5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SCG5 antibodies
     SCG5 proteins
     SCG5 lysates
     Antibodies for SCG5
     See all of Abcam's Antibodies, Kits and Proteins for SCG5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SCG5




     Proteins for SCG5
     Antibodies for SCG5
     ELISAs for SCG5
     CLIAs for SCG5
     Search LifeMap BioReagents cell lines for SCG5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCG5
     SwitchGear 3'UTR luciferase reporter plasmids for SCG5
     SwitchGear Promoter luciferase reporter plasmids for SCG5
     ThermoFisher Antibodies for SCG5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCG5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SCG5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCG5
    Customized:
     lentivirus for stable overexpression of SCG5
     lentivirus expression plasmids for stable overexpression of SCG5
     adenovirus for overexpression of SCG5
     LSBio Antibodies in human, mouse, rat for SCG5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SCG5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4