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Aliases for SCG5 Gene

Aliases for SCG5 Gene

  • Secretogranin V 2 3 4 5
  • Secretory Granule, Neuroendocrine Protein 1 (7B2 Protein) 2 3
  • Secretory Granule Endocrine Protein I 3 4
  • Prohormone Convertase Chaperone 2 3
  • Pituitary Polypeptide 3 4
  • Secretogranin-5 3 4
  • SGNE1 3 4
  • Neuroendocrine Protein 7B2 3
  • P7B2 3
  • 7B2 3
  • SgV 3

External Ids for SCG5 Gene

Previous HGNC Symbols for SCG5 Gene

  • SGNE1

Previous GeneCards Identifiers for SCG5 Gene

  • GC15P030722
  • GC15P032933
  • GC15P009796

Summaries for SCG5 Gene

Entrez Gene Summary for SCG5 Gene

  • This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. [provided by RefSeq, Jul 2016]

GeneCards Summary for SCG5 Gene

SCG5 (Secretogranin V) is a Protein Coding gene. Diseases associated with SCG5 include Hereditary Mixed Polyposis Syndrome 1 and Wolfram Syndrome. GO annotations related to this gene include GTP binding and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for SCG5 Gene

  • Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Gene Wiki entry for SCG5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCG5 Gene

Genomics for SCG5 Gene

Regulatory Elements for SCG5 Gene

Enhancers for SCG5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F032700 0.2 ENCODE 11.4 +59.7 59742 1.2 CTCF TFAP4 SAP130 FEZF1 RAD21 YY1 GATA3 RERE SMC3 NR2F6 LOC105370757 SCG5 ENSG00000212415 TMCO5B LOC105370756 GREM1
GH15F032701 0.8 ENCODE 11.4 +59.0 59016 0.2 SOX13 TFAP4 PKNOX1 SAP130 RAD21 YY1 GATA3 RERE NR2F6 FOS LOC105370757 SCG5 ENSG00000212415 LOC105370756 GREM1
GH15F032704 1.3 Ensembl ENCODE 11.4 +64.2 64189 3.5 ZNF664 JUND MAX FOS MYC GREM1 LOC105370757 SCG5 ENSG00000212415 LOC105370756
GH15F032662 1.3 Ensembl ENCODE 11.2 +21.2 21192 0.3 CTCF ZNF654 MBD1 SMC3 TRIM22 REST RAD21 SCG5 GREM1 ENSG00000212415 WHAMMP1 GC15P032669
GH15F032668 0.4 ENCODE 10.9 +27.4 27396 0.2 TEAD4 SCG5 ENSG00000212415 GC15P032669
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SCG5 on UCSC Golden Path with GeneCards custom track

Promoters for SCG5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001793510 131 801 TAL1 ARID1B JUND HDAC2 POLR2A NCOR1 MYNN THRAP3 KDM1A WT1

Genomic Location for SCG5 Gene

Chromosome:
15
Start:
32,641,669 bp from pter
End:
32,697,098 bp from pter
Size:
55,430 bases
Orientation:
Plus strand

Genomic View for SCG5 Gene

Genes around SCG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCG5 Gene

Proteins for SCG5 Gene

  • Protein details for SCG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05408-7B2_HUMAN
    Recommended name:
    Neuroendocrine protein 7B2
    Protein Accession:
    P05408
    Secondary Accessions:
    • P01164
    • Q6FHD0
    • Q9BS38

    Protein attributes for SCG5 Gene

    Size:
    212 amino acids
    Molecular mass:
    23730 Da
    Quaternary structure:
    • Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.

    Alternative splice isoforms for SCG5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCG5 Gene

Post-translational modifications for SCG5 Gene

  • Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.
  • Sulfated on tyrosine residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCG5 Gene

No data available for DME Specific Peptides for SCG5 Gene

Domains & Families for SCG5 Gene

Gene Families for SCG5 Gene

Protein Domains for SCG5 Gene

Suggested Antigen Peptide Sequences for SCG5 Gene

Graphical View of Domain Structure for InterPro Entry

P05408

UniProtKB/Swiss-Prot:

7B2_HUMAN :
  • Belongs to the 7B2 family.
Family:
  • Belongs to the 7B2 family.
genes like me logo Genes that share domains with SCG5: view

Function for SCG5 Gene

Molecular function for SCG5 Gene

UniProtKB/Swiss-Prot Function:
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Gene Ontology (GO) - Molecular Function for SCG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity ISS --
GO:0005515 protein binding IPI 7913882
GO:0005525 GTP binding TAS 3134253
GO:0051082 unfolded protein binding IDA 7913882
genes like me logo Genes that share ontologies with SCG5: view
genes like me logo Genes that share phenotypes with SCG5: view

Animal Models for SCG5 Gene

MGI Knock Outs for SCG5:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCG5 Gene

Localization for SCG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCG5 Gene

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCG5 Gene COMPARTMENTS Subcellular localization image for SCG5 gene
Compartment Confidence
extracellular 5
mitochondrion 3
cytoskeleton 2
cytosol 2
golgi apparatus 2
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030141 secretory granule IEA,ISS --
genes like me logo Genes that share ontologies with SCG5: view

Pathways & Interactions for SCG5 Gene

SuperPathways for SCG5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport ISS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0016486 peptide hormone processing ISS --
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with SCG5: view

No data available for Pathways by source and SIGNOR curated interactions for SCG5 Gene

Drugs & Compounds for SCG5 Gene

(30) Drugs for SCG5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(29) Additional Compounds for SCG5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SCG5: view

Transcripts for SCG5 Gene

Unigene Clusters for SCG5 Gene

Secretogranin V (7B2 protein):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCG5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7:

Relevant External Links for SCG5 Gene

GeneLoc Exon Structure for
SCG5
ECgene alternative splicing isoforms for
SCG5

Expression for SCG5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCG5 Gene

This gene is overexpressed in Pituitary (x6.7), Brain - Frontal Cortex (BA9) (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.3), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for SCG5 Gene

This gene is overexpressed in Cerebrospinal fluid (22.8), Frontal cortex (17.4), Vitreous humor (11.0), and Islet of Langerhans (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCG5 Gene



Protein tissue co-expression partners for SCG5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCG5 Gene:

SCG5

SOURCE GeneReport for Unigene cluster for SCG5 Gene:

Hs.156540
genes like me logo Genes that share expression patterns with SCG5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SCG5 Gene

Orthologs for SCG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCG5 34 35
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia SCG5 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCG5 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCG5 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scg5 34 16 35
  • 87.74 (n)
rat
(Rattus norvegicus)
Mammalia Scg5 34
  • 87.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SCG5 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCG5 34 35
  • 75.67 (n)
lizard
(Anolis carolinensis)
Reptilia SCG5 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scg5 34
  • 73.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397865 34
zebrafish
(Danio rerio)
Actinopterygii scg5 34 35 35
  • 70.24 (n)
zgc73132 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9417 34
Species where no ortholog for SCG5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCG5 Gene

ENSEMBL:
Gene Tree for SCG5 (if available)
TreeFam:
Gene Tree for SCG5 (if available)

Paralogs for SCG5 Gene

No data available for Paralogs for SCG5 Gene

Variants for SCG5 Gene

Sequence variations from dbSNP and Humsavar for SCG5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10083612 -- 32,668,424(+) TCCTC(A/G)TTTTA intron-variant
rs10083622 -- 32,668,345(+) AGGTA(C/T)GAATT intron-variant
rs10220719 -- 32,671,075(+) TCCCC(A/G)GGTTA intron-variant
rs10519737 -- 32,677,256(+) AACCA(A/C)TCGAT intron-variant
rs10549438 -- 32,680,195(+) TACTC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCG5 Gene

Variant ID Type Subtype PubMed ID
dgv4456n54 CNV gain 21841781
esv2422296 CNV duplication 17116639
esv2760023 CNV gain+loss 17122850
esv3307524 CNV mobile element insertion 20981092
esv33337 CNV gain+loss 17666407
esv3420441 CNV insertion 20981092
esv3581613 CNV loss 25503493
esv3892661 CNV gain 25118596
nsv1052620 CNV gain 25217958
nsv1481 CNV deletion 18451855
nsv428302 CNV gain+loss 18775914
nsv456785 CNV gain 19166990
nsv469587 CNV loss 16826518
nsv483039 CNV gain 15286789
nsv517740 CNV gain+loss 19592680
nsv568913 CNV gain 21841781
nsv568915 CNV gain 21841781
nsv568916 CNV loss 21841781

Variation tolerance for SCG5 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCG5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCG5 Gene

Disorders for SCG5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SCG5 Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hereditary mixed polyposis syndrome 1
  • colorectal adenoma and carcinoma 1
wolfram syndrome
  • wolfram syndrome 1
xanthogranulomatous pyelonephritis
  • pyelonephritis, xanthogranulomatous
- elite association - COSMIC cancer census association via MalaCards
Search SCG5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCG5

Genetic Association Database (GAD)
SCG5
Human Genome Epidemiology (HuGE) Navigator
SCG5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCG5
genes like me logo Genes that share disorders with SCG5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCG5 Gene

Publications for SCG5 Gene

  1. Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity. (PMID: 17617923) Bouatia-Naji N. … Meyre D. (BMC Med. Genet. 2007) 3 22 46 64
  2. Structural organization of the gene encoding the neuroendocrine chaperone 7B2. (PMID: 8617287) Braks J.A. … Martens G.J.M. (Eur. J. Biochem. 1996) 3 4 22 64
  3. Meta-analysis of new genome-wide association studies of colorectal cancer risk. (PMID: 21761138) Peters U. … Casey G. (Hum. Genet. 2012) 3 46 64
  4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M. … van Ree J.M. (Biol. Psychiatry 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SCG5 Gene

Sources for SCG5 Gene

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