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SCG5 Gene

protein-coding   GIFtS: 53
GCID: GC15P032933

Secretogranin V (7B2 Protein)

(Previous names: secretory granule, neuroendocrine protein 1 (7B2 protein))
(Previous symbol: SGNE1)
  Search for SCG5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secretogranin V (7B2 Protein)1 2     P7B22
SGNE11 2 3 5     SgV2
Secretory Granule, Neuroendocrine Protein 1 (7B2 Protein)1 2     Neuroendocrine Protein 7B22
Prohormone Convertase Chaperone1 2     secretogranin-52
Pituitary Polypeptide2 3     Secretogranin-53
Secretory Granule Endocrine Protein I2 3     Secretogranin V3
7B22     

External Ids:    HGNC: 108161   Entrez Gene: 64472   Ensembl: ENSG000001669227   OMIM: 1731205   UniProtKB: P054083   

Export aliases for SCG5 gene to outside databases

Previous GC identifers: GC15P030722 GC15P009796


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SCG5 Gene:
SCG5 (secretogranin V (7B2 protein)) is a protein-coding gene. GO annotations related to this gene include enzyme inhibitor activity and GTP binding.

UniProtKB/Swiss-Prot: 7B2_HUMAN, P05408
Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated
secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there
to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required
for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary
hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro

Gene Wiki entry for SCG5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NT_187660.1  NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCG5 gene promoter:
         c-Fos   AP-1   ATF-2   Lmo2   LUN-1   CUTL1   c-Jun   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCG5 promoter sequence
   Search Chromatin IP Primers for SCG5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13-q14   Ensembl cytogenetic band:  15q13.3   HGNC cytogenetic band: 15q13-q14

SCG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCG5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P032933:  view genomic region     (about GC identifiers)

Start:
32,933,870 bp from pter      End:
32,989,299 bp from pter
Size:
55,430 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 7B2_HUMAN, P05408 (See protein sequence)
Recommended Name: Neuroendocrine protein 7B2 precursor  
Size: 212 amino acids; 23730 Da
Subunit: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages
Secondary accessions: P01164 Q6FHD0 Q9BS38
Alternative splicing: 2 isoforms:  P05408-1   P05408-2   

Explore the universe of human proteins at neXtProt for SCG5: NX_P05408

Explore proteomics data for SCG5 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides (By similarity)1
  • Sulfated on tyrosine residues (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SCG5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138229.1  NP_003011.1  

    ENSEMBL proteins: 
     ENSP00000300175   ENSP00000388560   ENSP00000418430   ENSP00000420347   ENSP00000418485  

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    Novus Biologicals SCG5 Proteins
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    Cloud-Clone Corp. Proteins for SCG5

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007945 Secretogranin_V

    Graphical View of Domain Structure for InterPro Entry P05408

    ProtoNet protein and cluster: P05408

    1 Blocks protein domain: IPB007945 Neuroendocrine 7B2 precursor

    UniProtKB/Swiss-Prot: 7B2_HUMAN, P05408
    Similarity: Belongs to the 7B2 family


    Find genes that share domains with SCG5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 7B2_HUMAN, P05408
    Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated
    secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there
    to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required
    for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary
    hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ISS--
    GO:0005515protein binding IPI7913882
    GO:0005525GTP binding TAS3134253
    GO:0051082unfolded protein binding IDA7913882
         
    Find genes that share ontologies with SCG5           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Scg5):
     adipose tissue  behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  nervous system  reproductive system  respiratory system 

    Find genes that share phenotypes with SCG5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Scg5tm1Led for SCG5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCG5
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    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SCG5:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidSCG5 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for SCG5
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    7B2_HUMAN, P05408: Secreted. Note=Neuroendocrine and endocrine secretory granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030141secretory granule ISS--

    Find genes that share ontologies with SCG5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCG5
    Interactions:

        GeneGlobe Interaction Network for SCG5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SCG5 (P054082, 3 ENSP000003001754) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2863095 I2D: score=6 STRING: ENSP00000357292
    PCSK2P165193, ENSP000002625454I2D: score=2 STRING: ENSP00000262545
    PSTPIP1O435863, ENSP000003689144I2D: score=1 STRING: ENSP00000368914
    NR1H2P550553I2D: score=1 
    MYH10ENSP000002692434STRING: ENSP00000269243
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ISS--
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0016486peptide hormone processing ISS--
    GO:0043086negative regulation of catalytic activity ----
    GO:0046883regulation of hormone secretion ISS--

    Find genes that share ontologies with SCG5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCG5 (7B2)

    Selected Novoseek inferred chemical compound relationships for SCG5 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trimethylsilylisothiocyanate 78.8 1 11846383 (1)
    aitc 45.2 1 9324956 (1)
    metarhodopsin ii 43.7 9 10220390 (2), 10812086 (2), 17014882 (1)
    proglucagon 41.8 3 19223471 (2), 1678563 (1)
    aerolysin 40.9 1 1382579 (1)
    hirudin 33.4 7 9716158 (1), 7832783 (1), 2107100 (1), 8457193 (1) (see all 6)
    serine 32.7 5 8216207 (1), 9645470 (1), 9399575 (1), 17258834 (1) (see all 5)
    cyanogen bromide 28.3 1 1619632 (1)
    ctp 25.7 2 16122898 (1), 11018759 (1)
    phosphotyrosine 24.4 3 10543978 (1), 11746693 (1)



    Find genes that share compounds with SCG5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCG5 gene (2 alternative transcripts): 
    NM_001144757.1  NM_003020.3  

    Unigene Cluster for SCG5:

    Secretogranin V (7B2 protein)
    Hs.156540  [show with all ESTs]
    Unigene Representative Sequence: BU570828
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300175(uc001zha.2) ENST00000413748(uc001zgz.2) ENST00000494364
    ENST00000497208 ENST00000471027 ENST00000470349 ENST00000498069 ENST00000498607
    ENST00000475752
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SCG5:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidSCG5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SCG5
      QuantiFast Probe-based Assays in human, mouse, rat SCG5

    Additional mRNA sequence: 

    AK314965.1 BC005349.1 BC093053.1 CR541824.1 Y00757.1 

    12 DOTS entries:

    DT.100797562  DT.100797565  DT.100033593  DT.100797561  DT.97826920  DT.100726492  DT.99998701  DT.102829511 
    DT.100797564  DT.121080873  DT.91755963  DT.95149607 

    Selected AceView cDNA sequences (see all 519):

    BU072935 CB070120 BM509941 BU070612 F04599 BM509988 CA942119 CD106063 
    BQ778128 BQ272532 BI711742 BM505525 AA364943 BM505683 BU783864 BM503843 
    CA843449 BU073367 BP377248 CA843732 BP348127 CA868112 CA843812 T15926 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SCG5 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
    SP1:                                      -     -                 -     -                                 
    SP2:                                      -     -                 -     -                                 
    SP3:                                      -     -           -     -     -                                 
    SP4:                                      -     -           -     -     -                                 
    SP5:                                      -     -                                                         


    ECgene alternative splicing isoforms for SCG5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCAAGCA
    SCG5 Expression
    About this image


    SCG5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Islets of Langerhans
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    SCG5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCG5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.156540
        Custom PCR Arrays for SCG5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCG5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SCG5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scg51 , 5 secretogranin V1, 5 87.74(n)1
    91.98(a)1
      2 (57.45 cM)5
    203941  NM_009162.31  NP_033188.31 
     1137763625 
    chicken
    (Gallus gallus)
    Aves SCG51 secretogranin V (7B2 protein) 75.67(n)
    81.99(a)
      769742  XM_004941730.1  XP_004941787.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCG56
    secretogranin V (7B2 protein)
    82(a)
    1 ↔ 1
    1(32823194-32856163)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978652 X. laevis mRNA for 7B2 pituitary protein, partial cds 76.94(n)    X15608.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731322 hypothetical protein MGC73132 76.91(n)   393699  BC059495.1 


    ENSEMBL Gene Tree for SCG5 (if available)
    TreeFam Gene Tree for SCG5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCG5 (see all 1178)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs577898561,2
    --32932391(+) GCACAA/GTCTCA 2 -- us2k10--------
    rs1171857981,2
    F--32932516(+) GATACG/AGGATT 2 -- us2k11Minor allele frequency- A:0.02NA 120
    rs80371021,2
    C,F,A,H--32932650(+) TATGAG/AGTTTT 2 -- us2k1 tfbs328Minor allele frequency- A:0.27NS EA NA WA CSA 2476
    rs1846124311,2
    --32932767(+) AAAATA/GAAGAT 2 -- us2k10--------
    rs1165335891,2
    C,F--32932776(+) ATAACA/GATGAA 2 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1886322901,2
    --32932937(+) ATGAGC/TATCCG 2 -- us2k10--------
    rs787915921,2
    C,F--32933026(+) CTATTT/CATTGC 2 -- us2k11Minor allele frequency- C:0.17WA 118
    rs1812945791,2
    --32933092(+) TCTGGA/GTTCTA 2 -- us2k10--------
    rs1169813571,2
    C--32933363(+) GTGGAC/AGTTTA 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1500468511,2
    --32933368(+) CGTTTA/GGAAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCG5 (32933870 - 32989299 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SCG5 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422296CNV Duplication17116639
    esv271798CNV Insertion20981092
    nsv1481CNV Loss18451855
    nsv469587CNV Loss16826518
    nsv483039CNV Gain15286789
    nsv456785CNV Gain19166990
    nsv517740CNV Gain+Loss19592680
    esv33337CNV Gain+Loss17666407
    nsv428302CNV Gain+Loss18775914
    dgv728e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCG5
    DNA2.0 Custom Variant and Variant Library Synthesis for SCG5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173120    OMIM disorders: --


    Find genes that share disorders with SCG5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SCG5 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth syndrome ectopic 31.5 3 1752059 (2), 1424185 (1)
    glucagonoma 24.9 1 7517367 (1)
    cataplexy 18.7 1 16171287 (1)
    carcinoid 16.3 6 1752059 (2), 1424185 (1), 1674253 (1)
    autoimmune response 15.8 2 19473527 (1), 12571858 (1)
    insulinoma 15.7 8 9870681 (2), 7517367 (2), 1709861 (1)
    adrenoleukodystrophy 12.8 2 8002973 (1)
    metastasis 5.07 1 9083150 (1)
    colorectal cancer 4.42 1 16293189 (1)
    asthma 3.21 1 14713911 (1)

    Genetic Association Database (GAD): SCG5
    Human Genome Epidemiology (HuGE) Navigator: SCG5 (4 documents)

    Export disorders for SCG5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCG5 gene, integrated from 10 sources (see all 318):
    (articles sorted by number of sources associating them with SCG5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity. (PubMed id 17617923)1, 4, 9 Bouatia-Naji N....Meyre D. (BMC Med. Genet. 2007)
    2. Structural organization of the gene encoding the neuroendocrine chaperone 7B2. (PubMed id 8617287)1, 2, 9 Braks J.A.... Martens G.J.M. (Eur. J. Biochem. 1996)
    3. Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas. (PubMed id 8162254)1, 3, 9 Lloyd R.V. and Jin L. (Diagn. Mol. Pathol. 1994)
    4. Meta-analysis of new genome-wide association studies of colorectal cancer risk. (PubMed id 21761138)1, 4 Peters U....Casey G. (Hum. Genet. 2012)
    5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The chromogranin-secretogranin family. (PubMed id 12646671)1, 3 Taupenot L....O'Connor D.T. (N. Engl. J. Med. 2003)
    8. Neuroendocrine secretory protein 7B2: structure, expression and functions. (PubMed id 11439082)1, 2 Mbikay M.... Chretien M. (Biochem. J. 2001)
    9. 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway. (PubMed id 7913882)1, 2 Braks J.A. and Martens G.J.M. (Cell 1994)
    10. The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man. (PubMed id 1989596)1, 2 Paquet L.... Mbikay M. (Biochem. Biophys. Res. Commun. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6447 HGNC: 10816 AceView: SGNE1 Ensembl:ENSG00000166922 euGenes: HUgn6447
    ECgene: SCG5 H-InvDB: SCG5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCG5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SCG5 gene:
    Search GeneIP for patents involving SCG5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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