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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCG5 Gene

protein-coding   GIFtS: 54
GCID: GC15P032933

secretogranin V (7B2 protein)

(Previous names: secretory granule, neuroendocrine protein 1 (7B2 protein)...)
(Previous symbol: SGNE1)
 Explore 46 diseases affiliated with
SCG5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SCG5    

Aliases
for SCG5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Secretogranin V (7B2 Protein)1 2     P7B22
SGNE11 2 3 5     Neuroendocrine Protein 7B22
7B21 2     Prohormone Convertase Chaperone2
SgV1 2     Secretogranin-53
Secretory Granule, Neuroendocrine Protein 1 (7B2 Protein)1 2     Secretogranin-53
Pituitary Polypeptide2 3     Secretogranin V3
Secretory Granule Endocrine Protein I2 3     

External Ids:    HGNC: 108161   Entrez Gene: 64472   Ensembl: ENSG000001669227   OMIM: 1731205   UniProtKB: P054083   

Export aliases for SCG5 gene to outside databases

Previous GC identifers: GC15P030722 GC15P009796


Summaries
for SCG5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: 7B2_HUMAN, P05408
Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory
pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later
compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of
PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The
C-terminal peptide inhibits PCSK2 in vitro

Gene Wiki entry for SCG5


Genomic Views
for SCG5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCG5 gene promoter:
         c-Fos   AP-1   ATF-2   Lmo2   LUN-1   CUTL1   c-Jun   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCG5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCG5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13-q14   Ensembl cytogenetic band:  15q13.3   HGNC cytogenetic band: 15q13-q14

SCG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCG5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P032933:  view genomic region     (about GC identifiers)

Start:
 32,933,870 bp from pter      End:
 32,989,299 bp from pter
Size:
 55,430 bases      Orientation:
 plus strand

Proteins
for SCG5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 7B2_HUMAN, P05408 (See protein sequence)
Recommended Name: Neuroendocrine protein 7B2 precursor  
Size: 212 amino acids; 23730 Da
Subunit: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages
Subcellular location: Secreted. Note=Neuroendocrine and endocrine secretory granules
Secondary accessions: P01164 Q9BS38
Alternative splicing: 2 isoforms:  P05408-1   P05408-2   

Explore the universe of human proteins at neXtProt for SCG5: NX_P05408

Post-translational modifications:

  • Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides (By similarity)1
  • Sulfated on tyrosine residues (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P05408

    • SCG5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138229.1  NP_003011.1  

    ENSEMBL proteins: 
     ENSP00000300175   ENSP00000388560   ENSP00000418430   ENSP00000420347   ENSP00000418485  

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    Novus Biologicals SCG5 Proteins
    Novus Biologicals SCG5 Lysate
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    ProSpec Recombinant Protein for SCG5
    Uscn Proteins for SCG5

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005622intracellular ----
    GO:0030141secretory granule ISS--


    SCG5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SCG5

    Protein Domains /
    Families
    for SCG5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SCG5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007945 Secretogranin_V

    Graphical View of Domain Structure for InterPro Entry P05408

    ProtoNet protein and cluster: P05408

    1 Blocks protein family: IPB007945 Neuroendocrine 7B2 precursor

    UniProtKB/Swiss-Prot: 7B2_HUMAN, P05408
    Similarity: Belongs to the 7B2 family


    Function
    for SCG5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: 7B2_HUMAN, P05408
    Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory
    pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later
    compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of
    PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The
    C-terminal peptide inhibits PCSK2 in vitro

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: SCG5 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ISS--
    GO:0005515protein binding IPI7913882
    GO:0005525GTP binding TAS3134253
    GO:0051082unfolded protein binding IDA7913882


    SCG5 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Scg5tm1Led for SCG5
         14 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Scg5):
     adipose tissue  behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  nervous system  reproductive system  respiratory system 

    SCG5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SCG5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCG5

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for SCG5 (P054082, 3 ENSP000003001754) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2863095 I2D: score=6 STRING: ENSP00000357292
    PCSK2P165193, ENSP000002625454I2D: score=2 STRING: ENSP00000262545
    PSTPIP1O435863, ENSP000003689144I2D: score=1 STRING: ENSP00000368914
    NR1H2P550553I2D: score=1 
    KHDRBS1ENSP000003138294STRING: ENSP00000313829
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ISS--
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0016486peptide hormone processing ISS--
    GO:0043086negative regulation of catalytic activity ----
    GO:0046883regulation of hormone secretion ISS--


    SCG5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SCG5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCG5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCG5
    10/59 Novoseek chemical compound relationships for SCG5 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trimethylsilylisothiocyanate 78.8 1 11846383 (1)
    aitc 45.2 1 9324956 (1)
    metarhodopsin ii 43.7 9 10220390 (2), 10812086 (2), 17014882 (1)
    proglucagon 41.8 3 19223471 (2), 1678563 (1)
    aerolysin 40.9 1 1382579 (1)
    hirudin 33.4 7 9716158 (1), 7832783 (1), 2107100 (1), 8457193 (1) (see all 6)
    serine 32.7 5 8216207 (1), 9645470 (1), 9399575 (1), 17258834 (1) (see all 5)
    cyanogen bromide 28.3 1 1619632 (1)
    ctp 25.7 2 16122898 (1), 11018759 (1)
    phosphotyrosine 24.4 3 10543978 (1), 11746693 (1)

    Search CenterWatch for drugs/clinical trials and news about SCG5 / 7B2 

    Transcripts
    for SCG5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SCG5 gene (2 alternative transcripts): 
    NM_001144757.1  NM_003020.3  

    Unigene Cluster for SCG5:

    Secretogranin V (7B2 protein)
    Hs.156540  [show with all ESTs]
    Unigene Representative Sequence: BU570828
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300175(uc001zha.2) ENST00000413748(uc001zgz.2) ENST00000494364
    ENST00000497208 ENST00000471027 ENST00000470349 ENST00000498069 ENST00000498607
    ENST00000475752

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SCG5:
    hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmid: SCG5 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SCG5
    OriGene siRNA: SCG5
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    Clone
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    Additional cDNA sequence: 

    AK314965.1 BC005349.1 BC093053.1 CR541824.1 Y00757.1 

    12 DOTS entries:

    DT.100797562  DT.100797565  DT.100033593  DT.100797561  DT.97826920  DT.100726492  DT.99998701  DT.102829511 
    DT.100797564  DT.121080873  DT.91755963  DT.95149607 

    24/519 AceView cDNA sequences (see all 519):

    BU076018 CA843732 BM509988 BM565533 BM312983 BQ272532 CA848873 BM687876 
    CD106063 CA843449 BU950973 BQ286100 BQ268335 CA843700 BQ640002 BI439574 
    BQ270529 BU070372 CB068744 CA844346 BU785462 BM505525 BU785582 BQ548931 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SCG5 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
    SP1:                                      -     -                 -     -                                 
    SP2:                                      -     -                 -     -                                 
    SP3:                                      -     -           -     -     -                                 
    SP4:                                      -     -           -     -     -                                 
    SP5:                                      -     -                                                         


    ECgene alternative splicing isoforms for SCG5

    Expression
    for SCG5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATGCAAGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SCG5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    Gut TubeMidgutGut Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)

    See SCG5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCG5

    SOURCE GeneReport for Unigene cluster: Hs.156540
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    In Situ
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    Orthologs
    for SCG5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SCG5 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Scg55 secretogranin V   --   2 (57.45 cM) 113776362 
    chicken
    (Gallus gallus)    		 Aves SCG51 secretogranin V (7B2 protein) 75.87(n)
    82.38(a)    		   769742  XM_001233026.2  XP_001233027.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SCG56
    		 --
    		 82(a)
    		 1 ↔ 1
    		 1(32823194-32856163)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3978652 X. laevis mRNA for 7B2 pituitary protein, partial cds 76.94(n)    X15608.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc731322 hypothetical protein MGC73132 76.91(n)   393699  BC059495.1 


    ENSEMBL Gene Tree for SCG5 (if available)
    TreeFam Gene Tree for SCG5 (if available) 

    Paralogs
    for SCG5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SCG5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1041 NCBI SNPs in SCG5 are shown (see all 1041)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs113380671,2
    		C,F--9797089(+) GTCTCA/-AAAAA 1 -- int1 trp33Minor allele frequency- -:0.50NA 6
    rs45442141,2
    		C,F,A,H,--32931904(+) GCTGCA/TATACG 3 -- ds5001 us2k132Minor allele frequency- T:0.24NS EA NA WA CSA 2893
    rs1838701021,2
    		--32931906(+) TGCTAC/TACGGA 3 -- ds5001 us2k10--------
    rs284572171,2
    		C,F,H,--32931921(+) TACAGG/AAATGT 3 -- us2k1 ds500123Minor allele frequency- A:0.24NS EA NA WA 2706
    rs1868957191,2
    		--32932055(+) ATTTGA/TGGAAA 3 -- us2k1 ds50010--------
    rs1930874701,2
    		--32932080(+) CTGGAC/TGTGCA 3 -- us2k1 ds50010--------
    rs46432841,2
    		C,F,A,H,--32932098(+) CATGGC/GTTCTT 3 -- ds5001 us2k134Minor allele frequency- N:0.00NS EA NA WA CSA 2987
    rs353054941,2
    		C--32932139(+) TAATAT/CTAATT 3 -- ds5001 us2k12Minor allele frequency- C:0.00NA 4
    rs1858819071,2
    		--32932196(+) GGCCAC/TATTCT 3 -- us2k1 ds50010--------
    rs1898165861,2
    		--32932221(+) AAGAAC/GTTAAT 3 -- ds5001 us2k10--------

    HapMap Linkage Disequilibrium report for SCG5 (32933870 - 32989299 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for SCG5
         6 CNVs: 2191 0185 3075 7058 5324 3956

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    Disorders / Diseases
    for SCG5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SCG5 for disorders           About GeneDecksing

    OMIM gene information: 173120    OMIM disorders: --

    20/46 diseases for SCG5 (see all 46):    About MalaCards
    ehlers-danlos syndrome    xanthogranulomatous pyelonephritis    myasthenia gravis    autism spectrum disorder
    glucagonoma    glucose intolerance    herpes simplex    pituitary adenoma
    myasthenia    diabetes insipidus    adrenal hyperplasia    adrenoleukodystrophy
    wolfram syndrome    pituitary tumor    duodenal ulcer    insulinoma
    brain ischemia    pyelonephritis    duodenitis    pheochromocytoma

    10/41 Novoseek disease relationships for SCG5 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth syndrome ectopic 31.5 3 1752059 (2), 1424185 (1)
    glucagonoma 24.9 1 7517367 (1)
    cataplexy 18.7 1 16171287 (1)
    carcinoid 16.3 6 1752059 (2), 1424185 (1), 1674253 (1)
    autoimmune response 15.8 2 19473527 (1), 12571858 (1)
    insulinoma 15.7 8 9870681 (2), 7517367 (2), 1709861 (1)
    adrenoleukodystrophy 12.8 2 8002973 (1)
    metastasis 5.07 1 9083150 (1)
    colorectal cancer 4.42 1 16293189 (1)
    asthma 3.21 1 14713911 (1)

    Human Genome Epidemiology (HuGE) Navigator: SCG5 (4 documents)

    Export disorders for SCG5 gene to outside databases

    Publications
    for SCG5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCG5 gene, integrated from 9 sources (see all 312):
    (articles sorted by number of sources associating them with SCG5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural organization of the gene encoding the neuroendocrine chaperone 7B2. (PubMed id 8617287)1, 2, 9 Braks J.A.... Martens G.J. (1996)
    2. Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas. (PubMed id 8162254)1, 3, 9 Lloyd R.V. and Jin L. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The chromogranin-secretogranin family. (PubMed id 12646671)1, 3 Taupenot L....O'Connor D.T. (2003)
    5. Neuroendocrine secretory protein 7B2: structure, expression and functions. (PubMed id 11439082)1, 2 Mbikay M.... Chretien M. (2001)
    6. 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway. (PubMed id 7913882)1, 2 Braks J.A. and Martens G.J.M. (1994)
    7. The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man. (PubMed id 1989596)1, 2 Paquet L.... Mbikay M. (1991)
    8. Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2. (PubMed id 3134253)1, 2 Martens G.J.M. (1988)
    9. Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus. (PubMed id 6625600)1, 2 Seidah N.G.... Chretien M. (1983)
    10. Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity. (PubMed id 17617923)1, 9 Bouatia-Naji N....Meyre D. (2007)

    External Searches for SCG5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    Genome Databases showing SCG5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6447 HGNC: 10816 AceView: SGNE1 Ensembl:ENSG00000166922 euGenes: HUgn6447
    ECgene: SCG5 H-InvDB: SCG5

    Other Databases showing SCG5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SCG5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCG5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SCG5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SCG5 gene:
    Search GeneIP for patents involving SCG5

    GeneCards and IP:
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