Aliases for SCG5 Gene
External Ids for SCG5 Gene
Previous HGNC Symbols for SCG5 Gene
Previous GeneCards Identifiers for SCG5 Gene
GeneCards Summary for SCG5 Gene
SCG5 (Secretogranin V) is a Protein Coding gene. Diseases associated with SCG5 include hereditary mixed polyposis syndrome 1 and hereditary mixed polyposis syndrome. GO annotations related to this gene include GTP binding and enzyme inhibitor activity.
UniProtKB/Swiss-Prot for SCG5 Gene
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.