Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCG3 Gene

protein-coding   GIFtS: 51
GCID: GC15P051973

secretogranin III
 Explore 9 diseases affiliated with
SCG3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SCG3    

Aliases
for SCG3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Secretogranin III1 2 3
SGIII1 2
FLJ908331
Secretogranin-31
SgIII3

External Ids:    HGNC: 137071   Entrez Gene: 291062   Ensembl: ENSG000001041127   OMIM: 6117965   UniProtKB: Q8WXD23   

Export aliases for SCG3 gene to outside databases

Previous GC identifers: GC15P047530 GC15P045020 GC15P049552 GC15P049689 GC15P049760 GC15P028804


Summaries
for SCG3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SCG3:
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory
proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function
as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is
unknown. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep
2009)

Gene Wiki entry for SCG3


Genomic Views
for SCG3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCG3 gene promoter:
         STAT5B   AML1a   POU3F1   NRSF form 1   IRF-1   NRSF form 2   FAC1   SRY   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21   Ensembl cytogenetic band:  15q21.2   HGNC chromosome: 15

SCG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCG3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P051973:  view genomic region     (about GC identifiers)

Start:
 51,973,550 bp from pter      End:
 52,013,223 bp from pter
Size:
 39,674 bases      Orientation:
 plus strand

Proteins
for SCG3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SCG3_HUMAN, Q8WXD2 (See protein sequence)
Recommended Name: Secretogranin-3 precursor  
Size: 468 amino acids; 53005 Da
Subunit: Interacts with CHGA (By similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle lumen (By similarity). Cytoplasmic vesicle, secretory
vesicle membrane; Peripheral membrane protein (By similarity). Secreted. Note=Associated with the secretory granule
membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions (By similarity).
Neuroendocrine and endocrine secretory granules
Secondary accessions: A8K2B0 B3KQP6 B4DK99 F5H3R8 Q96C83 Q96GE8 Q9Y6G7
Alternative splicing: 2 isoforms:  Q8WXD2-1   Q8WXD2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCG3: NX_Q8WXD2

Post-translational modifications:

  • O-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WXD2

    • SCG3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158729.1  NP_037375.2  

    ENSEMBL proteins: 
     ENSP00000220478   ENSP00000445205   ENSP00000452745  
    Reactome Protein details: Q8WXD2
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SCG3
    OriGene Protein Over-expression Lysate: SCG3
    OriGene Custom Protein Services for SCG3 
    GenScript Custom Purified and Recombinant Proteins Services for SCG3
    Novus Biologicals SCG3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SCG3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0030141secretory granule TAS--
    GO:0030658transport vesicle membrane IEA--


    SCG3 for ontologies           About GeneDecksing



    SCG3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SCG3 
    GenScript Custom Superior Antibodies Services for SCG3
    Novus Biologicals SCG3 Antibodies
    Search for Antibodies for SCG3 at Abcam  
    Uscn Antibodies for SCG3
    Search ThermoFisher Antibodies for SCG3

    Assay Products for SCG3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCG3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SCG3

    Protein Domains /
    Families
    for SCG3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SCG3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026197 SCG3

    Graphical View of Domain Structure for InterPro Entry Q8WXD2

    ProtoNet protein and cluster: Q8WXD2


    Function
    for SCG3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): SCG3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCG3
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SCG3 (see all 9):
    hsa-miR-3163 hsa-miR-4291 hsa-miR-576-5p hsa-miR-4307 hsa-miR-4263 hsa-miR-606 hsa-miR-3920 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SCG3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCG3 (see all 7)
    OriGene shRNA RFP: SCG3
    OriGene siRNA: SCG3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCG3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SCG3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCG3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCG3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SCG3 (NM_013243)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCG3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SCG3
    Search LifeMap BioReagents cell lines for SCG3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCG3


    Pathways & Interactions
    for SCG3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Platelet degranulation
    		Platelet degranulation 1.00
    		Response to elevated platelet cytosolic Ca2+0.94
    2Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SCG3
        Hemostasis
    Platelet degranulation
    Platelet activation, signaling and aggregation
    Response to elevated platelet cytosolic Ca2+



    SCG3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCG3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for SCG3 (Q8WXD23 ENSP000002204784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGAP106453, ENSP000002164924I2D: score=1 STRING: ENSP00000216492
    PTK2Q053973I2D: score=1 
    FLNCENSP000003271454STRING: ENSP00000327145
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--


    SCG3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SCG3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCG3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCG3
    1 Novoseek chemical compound relationship for SCG3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 21.1 1 10027412 (1)

    Search CenterWatch for drugs/clinical trials and news about SCG3 

    Transcripts
    for SCG3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SCG3 gene (2 alternative transcripts): 
    NM_001165257.1  NM_013243.3  

    Unigene Cluster for SCG3:

    Secretogranin III
    Hs.232618  [show with all ESTs]
    Unigene Representative Sequence: AF453583
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220478(uc002abh.3 uc010ufz.2) ENST00000542355 ENST00000558709


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SCG3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCG3
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SCG3 (see all 9):
    hsa-miR-3163 hsa-miR-4291 hsa-miR-576-5p hsa-miR-4307 hsa-miR-4263 hsa-miR-606 hsa-miR-3920 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SCG3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCG3 (see all 7)
    OriGene shRNA RFP: SCG3
    OriGene siRNA: SCG3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCG3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCG3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCG3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SCG3 (NM_013243)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCG3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCG3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCG3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCG3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCG3

    Additional cDNA sequence: 

    AF078851.1 AF453583.1 AK075314.1 AK290175.1 AK296466.1 AY359093.1 BC009511.2 BC014539.1 

    7 DOTS entries:

    DT.113058  DT.95374661  DT.92432117  DT.100787799  DT.97845265  DT.92432116  DT.121075796 

    24/169 AceView cDNA sequences (see all 169):

    AI423166 BX488794 BQ637862 AI990706 BQ638034 BX094948 F11631 BQ130506 
    CR597634 AW444753 BM452526 AA127581 BQ128196 BI823378 AY359093 AA234547 
    BU176773 AA364934 AL713343 CA976030 AK075314 BQ288004 AA296990 AL517244 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SCG3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                              
    SP2:                          -                                                   


    ECgene alternative splicing isoforms for SCG3

    Expression
    for SCG3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGGGGACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SCG3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerCholinergic Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    BrainCerebral CortexBrain
    KidneyMetanephrosKidney
    Neural TubeDiencephalonNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Matrigel embedded cells (Derivation of cardio...)

    See SCG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCG3

    SOURCE GeneReport for Unigene cluster: Hs.232618

    UniProtKB/Swiss-Prot: SCG3_HUMAN, Q8WXD2
    Tissue specificity: Expressed in brain, heart, kidney, liver and skeletal muscle

        SABiosciences Custom PCR Arrays for SCG3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCG3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCG3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCG3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCG3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCG3

    Orthologs
    for SCG3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SCG3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Scg31 , 5 secretogranin III1, 5 86.11(n)1
    88.55(a)1    		   9 (42.32 cM)5
    202551  NM_001164790.11  NP_001158262.11 
     756433665 
    chicken
    (Gallus gallus)    		 Aves SCG31 secretogranin III 73.63(n)
    69.89(a)    		   415424  XM_413807.3  XP_413807.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SCG36
    		 --
    		 67(a)
    		 1 ↔ 1
    		 GL343330.1(682116-720932)
    African clawed frog
    (Xenopus laevis)    		 Amphibia scg3-A2 secretogranin III 76.18(n)    X92872.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc732362 hypothetical protein MGC73236 74.93(n)   393730  BC059577.1 


    ENSEMBL Gene Tree for SCG3 (if available)
    TreeFam Gene Tree for SCG3 (if available) 

    Paralogs
    for SCG3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SCG3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: SCG3_HUMAN, Q8WXD2
    Polymorphism: Polymorphisms in the 5'-flanking region and in intron 1 may have an effect on transcriptional activity
    and be associated with an increase in subcutaneous, but not visceral, fat area. Hence, may influence the risk of
    obesity


    10/772 NCBI SNPs in SCG3 are shown (see all 772)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs800773901,2
    		F,--28802447(+) AATCAC/TTTTAA 2 -- us2k11Minor allele frequency- T:0.02NA 120
    rs764717251,2
    		C,--28802557(+) TCCCAA/GTTGCA 2 -- us2k12Minor allele frequency- G:0.02WA 120
    rs9691931,2
    		H--28803311(-) TTGTAT/CACAAG 2 -- us2k1 tfbs34Minor allele frequency- C:0.00NS EA 416
    rs790264091,2
    		C,F,--28803675(+) TTCCCA/CATTCA 2 -- us2k11Minor allele frequency- C:0.14WA 118
    rs26061351,2
    		H,--28804114(-) GCGCAT/CGCTCC 2 -- ut514Minor allele frequency- C:0.00NS EA 414
    rs42686961,2
    		--28804324(+) CCTCTC/GCCGCC 2 -- ut51 ese3 trp30--------
    rs176486791,2
    		C,F,H,--28804602(+) GAGCTG/ATAAAT 2 -- int112Minor allele frequency- A:0.04NA NS EA 1016
    rs124424031,2
    		H--28804666(+) CAGTTC/TGAATT 2 -- int14Minor allele frequency- T:0.00NS EA 420
    rs747243881,2
    		F,--28804739(+) TTTTTA/GAAGAT 2 -- int11Minor allele frequency- G:0.03WA 118
    rs412864901,2
    		F,--28805001(+) AAATAC/TACCAA 2 -- int16Minor allele frequency- T:0.12EA CSA WA 3254

    HapMap Linkage Disequilibrium report for SCG3 (51973550 - 52013223 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SCG3: --
    Human Gene Mutation Database (HGMD): SCG3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCG3
    DNA2.0 Custom Variant and Variant Library Synthesis for SCG3

    Disorders / Diseases
    for SCG3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SCG3 for disorders           About GeneDecksing

    OMIM gene information: 611796    OMIM disorders: --

    9 diseases for SCG3:    About MalaCards
    pituitary adenoma    neuroendocrine tumor    adenoma    prostate cancer
    asthma    obesity    cholesterol    prostatitis
    pancreatitis

    2 Novoseek disease relationships for SCG3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma 20 3 7680355 (1), 8162254 (1)
    tumors 0 2 7680355 (1), 8162254 (1)

    Human Genome Epidemiology (HuGE) Navigator: SCG3 (5 documents)

    Export disorders for SCG3 gene to outside databases

    Publications
    for SCG3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCG3 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with SCG3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity. (PubMed id 17200173)1, 2, 9 Tanabe A....Hotta K. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Cloning and characterization of a novel human secretory protein: secretogranin III. (PubMed id 12098761)1, 2 Rong Y.P.... Han Z.G. (2002)
    5. The granin family--its role in sorting and secretory granule formation. (PubMed id 8825061)1, 3 Ozawa H. and Takata K. (1995)
    6. The granin (chromogranin/secretogranin) family. (PubMed id 2053134)1, 3 Huttner W.B....Rosa P. (1991)
    7. LDL oxidation by THP-1 monocytes: implication of HNP-1, SgIII and DMT-1. (PubMed id 19150442)1, 9 He C....Wu J. (2009)
    8. Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours. (PubMed id 18448176)1, 9 Stridsberg M....Janson E.T. (2008)
    9. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. (PubMed id 14630798)1, 9 Coppinger J.A....Maguire P.B. (2004)
    10. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (2013)

    External Searches for SCG3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SCG3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29106 HGNC: 13707 AceView: SCG3 Ensembl:ENSG00000104112 euGenes: HUgn29106
    ECgene: SCG3 H-InvDB: SCG3

    Other Databases showing SCG3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SCG3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCG3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SCG3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SCG3 gene:
    Search GeneIP for patents involving SCG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SCG3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SCG3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCG3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCG3  
     OriGene Protein Over-expression Lysate for SCG3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SCG3   OriGene 3'-UTR Clone for SCG3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCG3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCG3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SCG3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCG3   OriGene Custom Protein Services for SCG3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCG3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCG3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCG3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCG3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCG3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCG3
     GenScript Custom Purified and Recombinant Proteins Services for SCG3 GenScript cDNA clones with any tag delivered in your preferred vector for SCG3
     GenScript Custom Assay Services for SCG3 GenScript Custom Superior Antibodies Services for SCG3
     GenScript Custom overexpressing Cell Line Services for SCG3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SCG3 promoter
     Search Chromatin IP Primers for SCG3
     RT2 qPCR Primer Assay in human, mouse, rat SCG3
     GNC Network for SCG3
     SABiosciences Custom PCR Arrays for SCG3
     Search Tocris compounds for SCG3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SCG3 antibodies
     SCG3 lysates
     Search for Antibodies for SCG3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SCG3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SCG3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SCG3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCG3
     SwitchGear 3'UTR luciferase reporter plasmids for SCG3
     SwitchGear Promoter luciferase reporter plasmids for SCG3
     Search ThermoFisher Antibodies for SCG3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCG3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SCG3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4