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Aliases for SCG3 Gene

Aliases for SCG3 Gene

  • Secretogranin III 2 3 4
  • SGIII 3 4
  • Secretogranin-3 3

External Ids for SCG3 Gene

Previous GeneCards Identifiers for SCG3 Gene

  • GC15P047530
  • GC15P045020
  • GC15P049552
  • GC15P049689
  • GC15P049760
  • GC15P051973
  • GC15P028804

Summaries for SCG3 Gene

Entrez Gene Summary for SCG3 Gene

  • The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for SCG3 Gene

SCG3 (Secretogranin III) is a Protein Coding gene. Diseases associated with SCG3 include muscular dystrophy, limb-girdle, type 2c. Among its related pathways are Hemostasis and Hemostasis.

Gene Wiki entry for SCG3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCG3 Gene

Genomics for SCG3 Gene

Regulatory Elements for SCG3 Gene

Genomic Location for SCG3 Gene

51,681,353 bp from pter
51,721,031 bp from pter
39,679 bases
Plus strand

Genomic View for SCG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCG3 Gene

Proteins for SCG3 Gene

  • Protein details for SCG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K2B0
    • B3KQP6
    • B4DK99
    • F5H3R8
    • Q96C83
    • Q96GE8
    • Q9Y6G7

    Protein attributes for SCG3 Gene

    468 amino acids
    Molecular mass:
    53005 Da
    Quaternary structure:
    • Interacts with CHGA.

    Alternative splice isoforms for SCG3 Gene


neXtProt entry for SCG3 Gene

Proteomics data for SCG3 Gene at MOPED

Post-translational modifications for SCG3 Gene

Other Protein References for SCG3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SCG3 Gene

Domains for SCG3 Gene

Gene Families for SCG3 Gene

Protein Domains for SCG3 Gene


Suggested Antigen Peptide Sequences for SCG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SCG3: view

No data available for UniProtKB/Swiss-Prot for SCG3 Gene

Function for SCG3 Gene

Gene Ontology (GO) - Molecular Function for SCG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SCG3: view

Animal Model Products

miRNA for SCG3 Gene

miRTarBase miRNAs that target SCG3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCG3 Gene

Localization for SCG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCG3 Gene

Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions (By similarity). Neuroendocrine and endocrine secretory granules. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SCG3 Gene COMPARTMENTS Subcellular localization image for SCG3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SCG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0016020 membrane --
GO:0030658 transport vesicle membrane IEA --
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with SCG3: view

Pathways for SCG3 Gene

genes like me logo Genes that share pathways with SCG3: view

Interacting Proteins for SCG3 Gene

Gene Ontology (GO) - Biological Process for SCG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with SCG3: view

Compounds for SCG3 Gene

(1) Novoseek inferred chemical compound relationships for SCG3 Gene

Compound -log(P) Hits PubMed IDs
testosterone 21.1 1
genes like me logo Genes that share compounds with SCG3: view

Transcripts for SCG3 Gene

Unigene Clusters for SCG3 Gene

Secretogranin III:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCG3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCG3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: -

Relevant External Links for SCG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCG3 Gene

mRNA expression in normal human tissues for SCG3 Gene

mRNA differential expression in normal tissues according to GTEx for SCG3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (6.8), Brain - Cortex (5.8), Brain - Anterior cingulate cortex (BA24) (5.7), and Brain - Amygdala (4.5).

Protein differential expression in normal tissues for SCG3 Gene

This gene is overexpressed in Cerebrospinal fluid (54.8) and Nasal epithelium (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCG3 Gene

SOURCE GeneReport for Unigene cluster for SCG3 Gene Hs.232618

mRNA Expression by UniProt/SwissProt for SCG3 Gene

Tissue specificity: Expressed in brain, heart, kidney, liver and skeletal muscle.
genes like me logo Genes that share expressions with SCG3: view

Expression partners for SCG3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SCG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCG3 35
  • 90.46 (n)
  • 91.03 (a)
SCG3 36
  • 90 (a)
(Canis familiaris)
Mammalia SCG3 35
  • 92.2 (n)
  • 93.35 (a)
SCG3 36
  • 93 (a)
(Mus musculus)
Mammalia Scg3 35
  • 86.25 (n)
  • 88.89 (a)
Scg3 16
Scg3 36
  • 88 (a)
(Pan troglodytes)
Mammalia SCG3 35
  • 99.72 (n)
  • 99.79 (a)
SCG3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Scg3 35
  • 85.54 (n)
  • 88.46 (a)
(Monodelphis domestica)
Mammalia SCG3 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia SCG3 36
  • 41 (a)
(Gallus gallus)
Aves SCG3 35
  • 73.22 (n)
  • 68.87 (a)
SCG3 36
  • 62 (a)
(Anolis carolinensis)
Reptilia SCG3 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scg3 35
  • 66.52 (n)
  • 62.16 (a)
Str.14123 35
African clawed frog
(Xenopus laevis)
Amphibia scg3-A 35
(Danio rerio)
Actinopterygii scg3 35
  • 61.83 (n)
  • 56.7 (a)
zgc73236 35
scg3 36
  • 51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5512 35
Species with no ortholog for SCG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCG3 Gene

Gene Tree for SCG3 (if available)
Gene Tree for SCG3 (if available)

Paralogs for SCG3 Gene

No data available for Paralogs for SCG3 Gene

Variants for SCG3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SCG3 Gene

Polymorphisms in the 5-flanking region and in intron 1 may have an effect on transcriptional activity and be associated with an increase in subcutaneous, but not visceral, fat area. Hence, may influence the risk of obesity

Sequence variations from dbSNP and Humsavar for SCG3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs526556 -- 51,718,602(+) CAGCT(A/G)TTATT intron-variant
rs544023 -- 51,715,325(+) CGCTC(A/G)GCTTG intron-variant
rs716986 -- 51,687,616(+) ATTCC(A/G)GGCAC intron-variant
rs744039 -- 51,681,176(-) TTTAG(A/G)TAACC upstream-variant-2KB
rs897581 -- 51,681,241(-) ACCTC(C/T)CAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SCG3 Gene

Variant ID Type Subtype PubMed ID
nsv471243 CNV Gain 18288195
nsv904219 CNV Loss 21882294
nsv457139 CNV Loss 19166990
esv270503 CNV Insertion 20981092

Relevant External Links for SCG3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for SCG3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SCG3 Gene in MalaCards »

(1) Disease for SCG3 Gene

(2) Novoseek inferred disease relationships for SCG3 Gene

Disease -log(P) Hits PubMed IDs
adenoma 20 2
tumors 0 2

Relevant External Links for SCG3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SCG3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SCG3 Gene

Publications for SCG3 Gene

  1. Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity. (PMID: 17200173) Tanabe A. … Hotta K. (J. Clin. Endocrinol. Metab. 2007) 3 4 23 48
  2. LDL oxidation by THP-1 monocytes: implication of HNP-1, SgIII and DMT-1. (PMID: 19150442) He C. … Wu J. (Clin. Chim. Acta 2009) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours. (PMID: 18448176) Stridsberg M. … Janson E.T. (Regul. Pept. 2008) 3 23
  5. The granin (chromogranin/secretogranin) family. (PMID: 2053134) Huttner W.B. … Rosa P. (Trends Biochem. Sci. 1991) 2 3

Products for SCG3 Gene

Sources for SCG3 Gene

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