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Aliases for SCG3 Gene

Aliases for SCG3 Gene

  • Secretogranin III 2 3 4 5
  • SGIII 3 4

External Ids for SCG3 Gene

Previous GeneCards Identifiers for SCG3 Gene

  • GC15P047530
  • GC15P045020
  • GC15P049552
  • GC15P049689
  • GC15P049760
  • GC15P051973
  • GC15P028804

Summaries for SCG3 Gene

Entrez Gene Summary for SCG3 Gene

  • The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for SCG3 Gene

SCG3 (Secretogranin III) is a Protein Coding gene. Diseases associated with SCG3 include Muscular Dystrophy, Limb-Girdle, Type 2C. Among its related pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for SCG3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCG3 Gene

Genomics for SCG3 Gene

Regulatory Elements for SCG3 Gene

Enhancers for SCG3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCG3 on UCSC Golden Path with GeneCards custom track

Promoters for SCG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCG3 Gene

Chromosome:
15
Start:
51,681,353 bp from pter
End:
51,721,031 bp from pter
Size:
39,679 bases
Orientation:
Plus strand

Genomic View for SCG3 Gene

Genes around SCG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCG3 Gene

Proteins for SCG3 Gene

  • Protein details for SCG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXD2-SCG3_HUMAN
    Recommended name:
    Secretogranin-3
    Protein Accession:
    Q8WXD2
    Secondary Accessions:
    • A8K2B0
    • B3KQP6
    • B4DK99
    • F5H3R8
    • Q96C83
    • Q96GE8
    • Q9Y6G7

    Protein attributes for SCG3 Gene

    Size:
    468 amino acids
    Molecular mass:
    53005 Da
    Quaternary structure:
    • Interacts with CHGA.

    Alternative splice isoforms for SCG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCG3 Gene

Proteomics data for SCG3 Gene at MOPED

Post-translational modifications for SCG3 Gene

  • O-glycosylated.
  • Glycosylation at Asn 68, Thr 144, Thr 216, Thr 231, Asn 346, and Ser 359
  • Modification sites at PhosphoSitePlus

Other Protein References for SCG3 Gene

No data available for DME Specific Peptides for SCG3 Gene

Domains & Families for SCG3 Gene

Gene Families for SCG3 Gene

Protein Domains for SCG3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SCG3: view

No data available for UniProtKB/Swiss-Prot for SCG3 Gene

Function for SCG3 Gene

genes like me logo Genes that share phenotypes with SCG3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCG3

miRNA for SCG3 Gene

miRTarBase miRNAs that target SCG3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCG3 Gene

Localization for SCG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCG3 Gene

Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions (By similarity). Neuroendocrine and endocrine secretory granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCG3 Gene COMPARTMENTS Subcellular localization image for SCG3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
golgi apparatus 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SCG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with SCG3: view

Pathways & Interactions for SCG3 Gene

genes like me logo Genes that share pathways with SCG3: view

Interacting Proteins for SCG3 Gene

Gene Ontology (GO) - Biological Process for SCG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with SCG3: view

No data available for SIGNOR curated interactions for SCG3 Gene

Drugs & Compounds for SCG3 Gene

(1) Drugs for SCG3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SCG3: view

Transcripts for SCG3 Gene

Unigene Clusters for SCG3 Gene

Secretogranin III:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCG3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: -

Relevant External Links for SCG3 Gene

GeneLoc Exon Structure for
SCG3
ECgene alternative splicing isoforms for
SCG3

Expression for SCG3 Gene

mRNA expression in normal human tissues for SCG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCG3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.8), Brain - Cortex (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.7), and Brain - Amygdala (x4.5).

Protein differential expression in normal tissues from HIPED for SCG3 Gene

This gene is overexpressed in Cerebrospinal fluid (54.8) and Nasal epithelium (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCG3 Gene



SOURCE GeneReport for Unigene cluster for SCG3 Gene Hs.232618

mRNA Expression by UniProt/SwissProt for SCG3 Gene

Q8WXD2-SCG3_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver and skeletal muscle.
genes like me logo Genes that share expression patterns with SCG3: view

Protein tissue co-expression partners for SCG3 Gene

- Elite partner

Primer Products

Orthologs for SCG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCG3 35
  • 90.46 (n)
  • 91.03 (a)
SCG3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCG3 35
  • 92.2 (n)
  • 93.35 (a)
SCG3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scg3 35
  • 86.25 (n)
  • 88.89 (a)
Scg3 16
Scg3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCG3 35
  • 99.72 (n)
  • 99.79 (a)
SCG3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scg3 35
  • 85.54 (n)
  • 88.46 (a)
oppossum
(Monodelphis domestica)
Mammalia SCG3 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCG3 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCG3 35
  • 73.22 (n)
  • 68.87 (a)
SCG3 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCG3 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scg3 35
  • 66.52 (n)
  • 62.16 (a)
Str.14123 35
African clawed frog
(Xenopus laevis)
Amphibia scg3-A 35
zebrafish
(Danio rerio)
Actinopterygii scg3 35
  • 61.83 (n)
  • 56.7 (a)
zgc73236 35
scg3 36
  • 51 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5512 35
Species with no ortholog for SCG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCG3 Gene

ENSEMBL:
Gene Tree for SCG3 (if available)
TreeFam:
Gene Tree for SCG3 (if available)

Paralogs for SCG3 Gene

No data available for Paralogs for SCG3 Gene

Variants for SCG3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SCG3 Gene

SCG3_HUMAN-Q8WXD2
Polymorphisms in the 5-flanking region and in intron 1 may have an effect on transcriptional activity and be associated with an increase in subcutaneous, but not visceral, fat area. Hence, may influence the risk of obesity.

Sequence variations from dbSNP and Humsavar for SCG3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2305710 - 51,683,411(+) TAAGA(A/G)TGGAT reference, missense, utr-variant-5-prime
rs35664837 - 51,692,165(+) CTCCA(A/G)TGGCA reference, missense
rs17851186 - 51,688,362(+) AGCCG(C/T)GTTTG reference, missense, utr-variant-5-prime
rs5812561 -- 51,687,834(+) CATGT(-/G)GGGGA intron-variant
rs5812562 -- 51,688,564(+) TTTCT(-/AGG)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCG3 Gene

Variant ID Type Subtype PubMed ID
nsv471243 CNV Gain 18288195
nsv904219 CNV Loss 21882294
nsv457139 CNV Loss 19166990
esv270503 CNV Insertion 20981092

Variation tolerance for SCG3 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCG3 Gene

Human Gene Mutation Database (HGMD)
SCG3

Disorders for SCG3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCG3 Gene - From: OMIM

Disorder Aliases PubMed IDs
muscular dystrophy, limb-girdle, type 2c
  • sarcoglycan, gamma
- elite association - COSMIC cancer census association via MalaCards
Search SCG3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCG3

Genetic Association Database (GAD)
SCG3
Human Genome Epidemiology (HuGE) Navigator
SCG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCG3
genes like me logo Genes that share disorders with SCG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCG3 Gene

Publications for SCG3 Gene

  1. Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity. (PMID: 17200173) Tanabe A. … Hotta K. (J. Clin. Endocrinol. Metab. 2007) 3 4 23 48 67
  2. LDL oxidation by THP-1 monocytes: implication of HNP-1, SgIII and DMT-1. (PMID: 19150442) He C. … Wu J. (Clin. Chim. Acta 2009) 3 23
  3. Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours. (PMID: 18448176) Stridsberg M. … Janson E.T. (Regul. Pept. 2008) 3 23
  4. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. (PMID: 14630798) Coppinger J.A. … Maguire P.B. (Blood 2004) 3 23
  5. The granin family--its role in sorting and secretory granule formation. (PMID: 8825061) Ozawa H. … Takata K. (Cell Struct. Funct. 1995) 2 3

Products for SCG3 Gene

Sources for SCG3 Gene

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