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Aliases for SCG2 Gene

Aliases for SCG2 Gene

  • Secretogranin II 2 3 4
  • Chromogranin-C 3 4
  • Secretoneurin 2 3
  • SGII 3 4
  • CHGC 3 4
  • Chromogranin C 2
  • EM66 3
  • SN 3

External Ids for SCG2 Gene

Previous GeneCards Identifiers for SCG2 Gene

  • GC02M222484
  • GC02M223182
  • GC02M224425
  • GC02M224664
  • GC02M224287
  • GC02M224169
  • GC02M216313

Summaries for SCG2 Gene

Entrez Gene Summary for SCG2 Gene

  • The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCG2 Gene

SCG2 (Secretogranin II) is a Protein Coding gene. Diseases associated with SCG2 include lymph node cancer and collagenous colitis. GO annotations related to this gene include cytokine activity and chemoattractant activity.

UniProtKB/Swiss-Prot for SCG2 Gene

  • Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides

Gene Wiki entry for SCG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCG2 Gene

Genomics for SCG2 Gene

Regulatory Elements for SCG2 Gene

Genomic Location for SCG2 Gene

Chromosome:
2
Start:
223,596,940 bp from pter
End:
223,602,503 bp from pter
Size:
5,564 bases
Orientation:
Minus strand

Genomic View for SCG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCG2 Gene

Proteins for SCG2 Gene

  • Protein details for SCG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13521-SCG2_HUMAN
    Recommended name:
    Secretogranin-2
    Protein Accession:
    P13521
    Secondary Accessions:
    • B2R662
    • Q53T11
    • Q8TBH3

    Protein attributes for SCG2 Gene

    Size:
    617 amino acids
    Molecular mass:
    70941 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Binds calcium with a low-affinity

neXtProt entry for SCG2 Gene

Proteomics data for SCG2 Gene at MOPED

Post-translational modifications for SCG2 Gene

Other Protein References for SCG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SCG2 Gene

Domains & Families for SCG2 Gene

Gene Families for SCG2 Gene

Protein Domains for SCG2 Gene

Suggested Antigen Peptide Sequences for SCG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13521

UniProtKB/Swiss-Prot:

SCG2_HUMAN :
  • Belongs to the chromogranin/secretogranin protein family.
Family:
  • Belongs to the chromogranin/secretogranin protein family.
genes like me logo Genes that share domains with SCG2: view

Function for SCG2 Gene

Molecular function for SCG2 Gene

GENATLAS Biochemistry:
chromogranin C
UniProtKB/Swiss-Prot Function:
Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides

Gene Ontology (GO) - Molecular Function for SCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 14970115
GO:0005515 protein binding IPI 25416956
GO:0042056 chemoattractant activity IDA 9473216
genes like me logo Genes that share ontologies with SCG2: view
genes like me logo Genes that share phenotypes with SCG2: view

Animal Model Products

miRNA for SCG2 Gene

miRTarBase miRNAs that target SCG2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SCG2 Gene

Localization for SCG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCG2 Gene

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCG2 Gene COMPARTMENTS Subcellular localization image for SCG2 gene
Compartment Confidence
extracellular 5
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9473216
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with SCG2: view

Pathways & Interactions for SCG2 Gene

SuperPathways for SCG2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • cAMP / Ca2+ Signaling PathwayFinder in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for SCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IDA 14970115
GO:0001525 angiogenesis IDA 14970115
GO:0001937 negative regulation of endothelial cell proliferation TAS 9473216
GO:0001938 positive regulation of endothelial cell proliferation IDA 14970115
GO:0006954 inflammatory response TAS 14970115
genes like me logo Genes that share ontologies with SCG2: view

No data available for Pathways by source and SIGNOR curated interactions for SCG2 Gene

Drugs & Compounds for SCG2 Gene

(14) Drugs for SCG2 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Dopamine Approved Pharma Full agonist, Agonist 2814
Lithium Approved Pharma 206
Norepinephrine Approved Pharma 206
Acetylcholine Experimental Pharma Full agonist, Agonist 104

(13) Additional Compounds for SCG2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
adenylate
dithiothreitol
dopac
FMLP
genes like me logo Genes that share compounds with SCG2: view

Transcripts for SCG2 Gene

mRNA/cDNA for SCG2 Gene

Unigene Clusters for SCG2 Gene

Secretogranin II:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCG2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c
SP1: -
SP2: - -
SP3:

Relevant External Links for SCG2 Gene

GeneLoc Exon Structure for
SCG2
ECgene alternative splicing isoforms for
SCG2

Expression for SCG2 Gene

mRNA expression in normal human tissues for SCG2 Gene

mRNA differential expression in normal tissues according to GTEx for SCG2 Gene

This gene is overexpressed in Brain - Hypothalamus (x10.4), Brain - Nucleus accumbens (basal ganglia) (x7.8), Pituitary (x6.0), Brain - Caudate (basal ganglia) (x4.4), and Brain - Putamen (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for SCG2 Gene

This gene is overexpressed in Islet of Langerhans (22.7), Cerebrospinal fluid (9.8), Amniocyte (7.9), and Bone marrow stromal cell (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCG2 Gene



SOURCE GeneReport for Unigene cluster for SCG2 Gene Hs.516726

genes like me logo Genes that share expression patterns with SCG2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SCG2 Gene

Orthologs for SCG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCG2 35
  • 89.69 (n)
  • 88.22 (a)
SCG2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCG2 35
  • 89.99 (n)
  • 89.89 (a)
SCG2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scg2 35
  • 83.2 (n)
  • 82.11 (a)
Scg2 16
Scg2 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCG2 35
  • 99.35 (n)
  • 99.19 (a)
SCG2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scg2 35
  • 82.01 (n)
  • 81.04 (a)
oppossum
(Monodelphis domestica)
Mammalia SCG2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCG2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCG2 35
  • 67.1 (n)
  • 59.61 (a)
SCG2 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCG2 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scg2 35
  • 59.52 (n)
  • 50.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397939 35
zebrafish
(Danio rerio)
Actinopterygii scg2b 35
  • 46.75 (n)
  • 33.54 (a)
scg2a 36
  • 24 (a)
OneToMany
scg2b 36
  • 27 (a)
OneToMany
Species with no ortholog for SCG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCG2 Gene

ENSEMBL:
Gene Tree for SCG2 (if available)
TreeFam:
Gene Tree for SCG2 (if available)

Paralogs for SCG2 Gene

No data available for Paralogs for SCG2 Gene

Variants for SCG2 Gene

Sequence variations from dbSNP and Humsavar for SCG2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs721233 -- 223,597,996(-) CCAGA(C/T)GGGCT reference, synonymous-codon
rs1017448 -- 223,601,626(-) GGGTT(A/G)TAATT intron-variant
rs1049577 -- 223,597,187(+) AGAAA(A/G)ATATC utr-variant-3-prime
rs1438157 - 223,598,696(+) ATGTA(A/G)CAAGG reference, missense
rs1439922 -- 223,598,576(-) CAAGG(C/T)TAATA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SCG2 Gene

Variant ID Type Subtype PubMed ID
nsv834553 CNV Gain 17160897

Variation tolerance for SCG2 Gene

Residual Variation Intolerance Score: 20.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCG2 Gene

HapMap Linkage Disequilibrium report
SCG2
Human Gene Mutation Database (HGMD)
SCG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCG2 Gene

Disorders for SCG2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SCG2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
lymph node cancer
  • lymph node neoplasm
collagenous colitis
  • microscopic colitis, collagenous type
neuroendocrine tumor
  • neuroendocrine neoplasm
pick disease
  • pick's disease
pheochromocytoma
  • pheochromocytoma, modifier of
- elite association
Search SCG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCG2

Genetic Association Database (GAD)
SCG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCG2
genes like me logo Genes that share disorders with SCG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCG2 Gene

Publications for SCG2 Gene

  1. Sensory neuropeptides are potent chemoattractants for human basophils in vitro. (PMID: 20035805) Cima K. … KAohler C.M. (Regul. Pept. 2010) 23 67
  2. Chromogranins A and B and secretogranin II as prohormones for regulatory peptides from the diffuse neuroendocrine system. (PMID: 20217490) Helle K.B. (Results Probl Cell Differ 2010) 23 67
  3. Chromogranin peptides in amyotrophic lateral sclerosis. (PMID: 18721831) Schrott-Fischer A. … Marksteiner J. (Regul. Pept. 2009) 23 67
  4. 3', 5'-cyclic adenosine 5'-monophosphate response element-dependent transcriptional regulation of the secretogranin II gene promoter depends on gonadotropin-releasing hormone-induced mitogen-activated protein kinase activation and the transactivator activating transcription factor 3. (PMID: 17962349) Xie J. … Roberson M.S. (Endocrinology 2008) 23 67
  5. Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke. (PMID: 18079966) Shyu W.C. … Li H. (J. Clin. Invest. 2008) 23 67

Products for SCG2 Gene

Sources for SCG2 Gene

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