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Aliases for SCG2 Gene

Aliases for SCG2 Gene

  • Secretogranin II 2 3 4 5
  • Chromogranin-C 3 4
  • Secretoneurin 2 3
  • CHGC 3 4
  • SgII 3 4
  • Secretogranin-2 3
  • Chromogranin C 2
  • EM66 3
  • SN 3

External Ids for SCG2 Gene

Previous GeneCards Identifiers for SCG2 Gene

  • GC02M222484
  • GC02M223182
  • GC02M224425
  • GC02M224664
  • GC02M224287
  • GC02M224169
  • GC02M216313

Summaries for SCG2 Gene

Entrez Gene Summary for SCG2 Gene

  • The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCG2 Gene

SCG2 (Secretogranin II) is a Protein Coding gene. Diseases associated with SCG2 include Intracranial Primitive Neuroectodermal Tumor and Lymph Node Cancer. GO annotations related to this gene include cytokine activity and chemoattractant activity.

UniProtKB/Swiss-Prot for SCG2 Gene

  • Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.

Gene Wiki entry for SCG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCG2 Gene

Genomics for SCG2 Gene

Regulatory Elements for SCG2 Gene

Enhancers for SCG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F223603 0.4 FANTOM5 18.1 -0.7 -663 0.2 SMARCA4 SCG2 GC02P223632
GH02F223587 0.3 FANTOM5 4.8 +14.5 14538 0.4 SCG2 ENSG00000235610
GH02F223204 0.2 ENCODE 5 +398.1 398129 1.1 SCG2 LOC105373906 GC02P223185
GH02F223602 0.9 ENCODE 0.8 +0.1 126 0.2 ELF3 ATF1 SIN3A ZNF48 ZSCAN9 RAD21 RARA SLC30A9 ZNF143 RCOR1 SCG2 ENSG00000235610
GH02F223612 1.5 FANTOM5 Ensembl ENCODE 0.4 -10.8 -10799 1.6 TBP SIN3A RAD21 RFX5 ZNF366 FOS EGR2 SMARCC1 CEBPB ZEB2 SERPINE2 SCG2 GC02P223632
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCG2 on UCSC Golden Path with GeneCards custom track

Promoters for SCG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001833001 102 799 ELF3 ATF1 SIN3A ZNF48 ZSCAN9 RAD21 RARA SLC30A9 ZNF143 RCOR1

Genomic Location for SCG2 Gene

Chromosome:
2
Start:
223,596,940 bp from pter
End:
223,602,503 bp from pter
Size:
5,564 bases
Orientation:
Minus strand

Genomic View for SCG2 Gene

Genes around SCG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCG2 Gene

Proteins for SCG2 Gene

  • Protein details for SCG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13521-SCG2_HUMAN
    Recommended name:
    Secretogranin-2
    Protein Accession:
    P13521
    Secondary Accessions:
    • B2R662
    • Q53T11
    • Q8TBH3

    Protein attributes for SCG2 Gene

    Size:
    617 amino acids
    Molecular mass:
    70941 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Binds calcium with a low-affinity.

neXtProt entry for SCG2 Gene

Post-translational modifications for SCG2 Gene

Other Protein References for SCG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCG2 Gene

Domains & Families for SCG2 Gene

Gene Families for SCG2 Gene

Protein Domains for SCG2 Gene

Suggested Antigen Peptide Sequences for SCG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13521

UniProtKB/Swiss-Prot:

SCG2_HUMAN :
  • Belongs to the chromogranin/secretogranin protein family.
Family:
  • Belongs to the chromogranin/secretogranin protein family.
genes like me logo Genes that share domains with SCG2: view

Function for SCG2 Gene

Molecular function for SCG2 Gene

GENATLAS Biochemistry:
chromogranin C
UniProtKB/Swiss-Prot Function:
Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.

Gene Ontology (GO) - Molecular Function for SCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 14970115
GO:0005515 protein binding IPI 25416956
GO:0042056 chemoattractant activity IDA 9473216
genes like me logo Genes that share ontologies with SCG2: view
genes like me logo Genes that share phenotypes with SCG2: view

Animal Models for SCG2 Gene

MGI Knock Outs for SCG2:
  • Scg2 tm1.1(KOMP)Vlcg

Animal Model Products

miRNA for SCG2 Gene

miRTarBase miRNAs that target SCG2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCG2 Gene

Localization for SCG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCG2 Gene

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCG2 gene
Compartment Confidence
extracellular 5
nucleus 3
golgi apparatus 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 9473216
GO:0030141 secretory granule IEA --
GO:0031045 dense core granule IEA --
genes like me logo Genes that share ontologies with SCG2: view

Pathways & Interactions for SCG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IDA 14970115
GO:0001525 angiogenesis IEA,IDA 14970115
GO:0001937 negative regulation of endothelial cell proliferation TAS 9473216
GO:0001938 positive regulation of endothelial cell proliferation IDA 14970115
GO:0006954 inflammatory response TAS 14970115
genes like me logo Genes that share ontologies with SCG2: view

No data available for Pathways by source and SIGNOR curated interactions for SCG2 Gene

Drugs & Compounds for SCG2 Gene

(15) Drugs for SCG2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(12) Additional Compounds for SCG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SCG2: view

Transcripts for SCG2 Gene

mRNA/cDNA for SCG2 Gene

Unigene Clusters for SCG2 Gene

Secretogranin II:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCG2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c
SP1: -
SP2: - -
SP3:

Relevant External Links for SCG2 Gene

GeneLoc Exon Structure for
SCG2
ECgene alternative splicing isoforms for
SCG2

Expression for SCG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCG2 Gene

mRNA differential expression in normal tissues according to GTEx for SCG2 Gene

This gene is overexpressed in Brain - Hypothalamus (x10.4), Brain - Nucleus accumbens (basal ganglia) (x7.8), Pituitary (x6.0), Brain - Caudate (basal ganglia) (x4.4), and Brain - Putamen (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for SCG2 Gene

This gene is overexpressed in Islet of Langerhans (22.7), Cerebrospinal fluid (9.8), Amniocyte (7.9), and Bone marrow stromal cell (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCG2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SCG2 Gene:

SCG2

SOURCE GeneReport for Unigene cluster for SCG2 Gene:

Hs.516726
genes like me logo Genes that share expression patterns with SCG2: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SCG2 Gene

Orthologs for SCG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCG2 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia SCG2 34 35
  • 89.99 (n)
cow
(Bos Taurus)
Mammalia SCG2 34 35
  • 89.69 (n)
mouse
(Mus musculus)
Mammalia Scg2 34 16 35
  • 83.2 (n)
rat
(Rattus norvegicus)
Mammalia Scg2 34
  • 82.01 (n)
oppossum
(Monodelphis domestica)
Mammalia SCG2 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCG2 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCG2 34 35
  • 67.1 (n)
lizard
(Anolis carolinensis)
Reptilia SCG2 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scg2 34
  • 59.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397939 34
zebrafish
(Danio rerio)
Actinopterygii scg2b 34 35
  • 46.75 (n)
scg2a 35
  • 24 (a)
OneToMany
Species where no ortholog for SCG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCG2 Gene

ENSEMBL:
Gene Tree for SCG2 (if available)
TreeFam:
Gene Tree for SCG2 (if available)

Paralogs for SCG2 Gene

No data available for Paralogs for SCG2 Gene

Variants for SCG2 Gene

Sequence variations from dbSNP and Humsavar for SCG2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1017448 -- 223,601,626(-) GGGTT(A/G)TAATT intron-variant
rs1049577 -- 223,597,187(-) AGAAA(A/G)ATATC utr-variant-3-prime
rs111603439 -- 223,598,967(+) TTCAC(C/T)CAGTG reference, missense
rs112384380 -- 223,599,001(+) TCATC(A/G/T)CCATT reference, synonymous-codon
rs112627018 -- 223,599,299(+) TTCCT(A/C/T)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCG2 Gene

Variant ID Type Subtype PubMed ID
nsv584549 CNV gain 21841781
nsv834553 CNV gain 17160897

Variation tolerance for SCG2 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCG2 Gene

Human Gene Mutation Database (HGMD)
SCG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCG2 Gene

Disorders for SCG2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SCG2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
intracranial primitive neuroectodermal tumor
  • intracranial pnet
lymph node cancer
  • lymph node neoplasm
neuroendocrine tumor
  • neuroendocrine neoplasm
collagenous colitis
  • microscopic colitis, collagenous type
askin's tumor
  • askin tumor
- elite association - COSMIC cancer census association via MalaCards
Search SCG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCG2

Genetic Association Database (GAD)
SCG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCG2
genes like me logo Genes that share disorders with SCG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCG2 Gene

Publications for SCG2 Gene

  1. Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study. (PMID: 20200953) Karasik D. … Demissie S. (J. Bone Miner. Res. 2010) 3 46 64
  2. Chromogranin peptides in amyotrophic lateral sclerosis. (PMID: 18721831) Schrott-Fischer A. … Marksteiner J. (Regul. Pept. 2009) 3 22 64
  3. Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells. (PMID: 18239671) Li L. … Porter A.G. (Cell Death Differ. 2008) 3 22 64
  4. Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours. (PMID: 18448176) Stridsberg M. … Janson E.T. (Regul. Pept. 2008) 3 22 64
  5. An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. (PMID: 17584765) Wen G. … Hamilton B.A. (Hum. Mol. Genet. 2007) 3 22 64

Products for SCG2 Gene

Sources for SCG2 Gene

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