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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCG2 Gene

protein-coding   GIFtS: 54
GCID: GC02M224425

secretogranin II
 Explore 42 diseases affiliated with
SCG2 via
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Biological research products
for SCG2    

Aliases
for SCG2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Secretogranin II1 2 3     Chromogranin-C3
CHGC1 2 3 5     Secretogranin-21
SgII1 2 3     Secretoneurin1
SN1 2     Chromogranin-C3
EM662     

External Ids:    HGNC: 105751   Entrez Gene: 78572   Ensembl: ENSG000001719517   OMIM: 1189305   UniProtKB: P135213   

Export aliases for SCG2 gene to outside databases

Previous GC identifers: GC02M222484 GC02M223182 GC02M224664 GC02M224287 GC02M224169 GC02M216313


Summaries
for SCG2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SCG2:
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory
proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or
sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce
the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is
unknown. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SCG2_HUMAN, P13521
Function: Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active
peptides

Gene Wiki entry for SCG2


Genomic Views
for SCG2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCG2 gene promoter:
         Nkx3-1   Nkx3-1 v4   AP-1   Nkx3-1 v1   Nkx2-5   POU3F2   Nkx3-1 v2   S8   Nkx3-1 v3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35-q36   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q35-q36

SCG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCG2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M224425:  view genomic region     (about GC identifiers)

Start:
 224,461,658 bp from pter      End:
 224,467,221 bp from pter
Size:
 5,564 bases      Orientation:
 minus strand

Proteins
for SCG2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SCG2_HUMAN, P13521 (See protein sequence)
Recommended Name: Secretogranin-2 precursor  
Size: 617 amino acids; 70941 Da
Subcellular location: Secreted. Note=Neuroendocrine and endocrine secretory granules
Miscellaneous: Binds calcium with a low-affinity
Secondary accessions: B2R662 Q53T11 Q8TBH3

Explore the universe of human proteins at neXtProt for SCG2: NX_P13521

Post-translational modifications:

  • O-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13521

    • SCG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003460.2  
    ENSEMBL proteins: 
     ENSP00000304133   ENSP00000394702   ENSP00000415468  

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    Novus Biologicals SCG2 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SCG2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA9473216
    GO:0005622intracellular ----
    GO:0030141secretory granule IEA--


    SCG2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SCG2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SCG2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001990 Granin
     IPR018054 Chromogranin_CS

    Graphical View of Domain Structure for InterPro Entry P13521

    ProtoNet protein and cluster: P13521

    1 Blocks protein family: IPB001990 Chromogranin/secretogranin

    UniProtKB/Swiss-Prot: SCG2_HUMAN, P13521
    Similarity: Belongs to the chromogranin/secretogranin protein family


    Function
    for SCG2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SCG2_HUMAN, P13521
    Function: Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active
    peptides

         Genatlas biochemistry entry for SCG2:
    chromogranin C

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SCG2 (see all 10):
    hsa-miR-495 hsa-miR-548am hsa-miR-198 hsa-miR-7-2* hsa-miR-548e hsa-miR-1324 hsa-miR-548a-3p hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: SCG2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCG2 (see all 7)
    OriGene shRNA RFP: SCG2
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IDA14970115
    GO:0042056chemoattractant activity IDA9473216


    SCG2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SCG2:
     Decreased viability of wild-ty  Increased S DNA content, incre 


    Pathways & Interactions
    for SCG2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/19 Interacting proteins for SCG2 (P135212, 3 ENSP000003041334) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2864347 MINT-2864328 I2D: score=3 STRING: ENSP00000357292
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    SCHIP1Q9P0W53I2D: score=1 
    UBQLN1Q9UMX03I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA14970115
    GO:0001525angiogenesis IDA14970115
    GO:0001937negative regulation of endothelial cell proliferation TAS9473216
    GO:0001938positive regulation of endothelial cell proliferation IDA14970115
    GO:0006928cellular component movement IDA9473216


    SCG2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SCG2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCG2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCG2

    1 HMDB Compound for SCG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/27 Novoseek chemical compound relationships for SCG2 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    secretoneurin 99 515 12694392 (11), 12626352 (10), 16904976 (10), 15727576 (10) (see all 83)
    fmlp 43 8 9688329 (2), 9655476 (1), 8878121 (1), 9988125 (1) (see all 5)
    capsaicin 34.3 13 15727576 (3), 15671295 (1), 11245085 (1), 8075827 (1) (see all 6)
    forskolin 31.5 6 9575827 (2), 12969248 (1), 12392156 (1), 10619397 (1)
    polycarbonate 21.3 1 11202062 (1)
    12-o-tetradecanoylphorbol 13-acetate 18.7 2 10619397 (1)
    tyrosine 18.6 10 12392156 (2), 8731045 (2), 15663480 (1), 1601888 (1) (see all 7)
    cyclic amp 18.5 5 10648883 (2), 18239671 (1)
    glycosaminoglycan 17.9 2 7962053 (1)
    dopac 12.8 1 7616217 (1)

    Search CenterWatch for drugs/clinical trials and news about SCG2 

    Transcripts
    for SCG2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SCG2 gene: 
    NM_003469.4  

    Unigene Cluster for SCG2:

    Secretogranin II
    Hs.516726  [show with all ESTs]
    Unigene Representative Sequence: NM_003469
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305409(uc002vnm.3) ENST00000421386 ENST00000433889

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SCG2 (see all 10):
    hsa-miR-495 hsa-miR-548am hsa-miR-198 hsa-miR-7-2* hsa-miR-548e hsa-miR-1324 hsa-miR-548a-3p hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: SCG2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK298828.1 AK312452.1 BC022509.1 M25756.1 

    10 DOTS entries:

    DT.455603  DT.100822391  DT.100822398  DT.86852632  DT.100822394  DT.100822395  DT.121000289  DT.121000294 
    DT.97767691  DT.92432310 

    24/188 AceView cDNA sequences (see all 188):

    BG654672 CD107534 BQ718355 CB157911 CD107750 AA384796 CD108215 BG654871 
    AI671205 CA776429 H54915 BM510018 BQ007002 BP362728 BM759919 BQ788118 
    CD250914 CA843363 BI792350 CB160906 CA843616 CD251718 BM310607 AI079373 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SCG2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c
    SP1:              -                           
    SP2:              -     -                     
    SP3:                                          


    ECgene alternative splicing isoforms for SCG2

    Expression
    for SCG2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGAAAACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SCG2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    AdiposeBody Subcutaneous White AdiposeAdipose
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)

    See SCG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCG2

    SOURCE GeneReport for Unigene cluster: Hs.516726
        SABiosciences Expression via Pathway-Focused PCR Arrays including SCG2: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for SCG2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SCG2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Scg21 , 5 secretogranin II1, 5 83.2(n)1
    82.11(a)1    		   1 (40.89 cM)5
    202541  NM_009129.21  NP_033155.11 
     794346695 
    chicken
    (Gallus gallus)    		 Aves SCG21 secretogranin II 67.16(n)
    59.61(a)    		   424808  XM_422624.3  XP_422624.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SCG26
    		 --
    		 59(a)
    		 1 ↔ 1
    		 3(25167037-25168893)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3979392 secretogranin II 72.54(n)    X92873.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii scg2b1 secretogranin II (chromogranin C), b 46.75(n)
    34.8(a)    		   777641  NM_001077748.1  NP_001071216.1 


    ENSEMBL Gene Tree for SCG2 (if available)
    TreeFam Gene Tree for SCG2 (if available) 

    Paralogs
    for SCG2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SCG2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/146 NCBI SNPs in SCG2 are shown (see all 146)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs783430331,2
    		--216313434(+) GCTTCG/ATAGAC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs168649691,2
    		C,F,H,--216313720(+) TAGATA/TTCTTT 1 -- ut3110Minor allele frequency- T:0.04NA NS EA CSA WA 800
    rs10495771,2
    		C,H--216313722(-) AGAAAG/AATATC 1 -- ut313Minor allele frequency- A:0.38MN NS NA 412
    rs22301681,2
    		C,F,O,H,--216313873(-) GTTAAC/AACTGT 1 -- ut31 ese320Minor allele frequency- A:0.10MN NA NS EA WA CSA 2064
    rs178566691,2
    		H--216314557(+) AGCACG/CACCAG 2 /R /G mis15Minor allele frequency- C:0.00NS EA NA 418
    rs14399221,2
    		C,F,H--216315111(-) CAAGGC/TTAATA 2 A V mis1 ese310Minor allele frequency- T:0.01MN NS EA NA 1218
    rs14381571,2
    		C,F,H--216315231(+) ATGTAG/ACAAGG 2 /A /V mis18Minor allele frequency- A:0.01MN NS EA NA 1174
    rs751608001,2
    		F,--216315883(+) GACACT/CATAGC 1 -- int12Minor allele frequency- C:0.02NA EA 240
    rs744910581,2
    		F,--216315888(+) TATAGC/TAAAAG 1 -- int11Minor allele frequency- T:0.08WA 118
    rs168649771,2
    		C,F,--216316054(+) AACTTG/TCATAG 1 -- int15Minor allele frequency- T:0.02NA EA 262

    HapMap Linkage Disequilibrium report for SCG2 (224461658 - 224467221 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SCG2: --
    Human Gene Mutation Database (HGMD): SCG2

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    Disorders / Diseases
    for SCG2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SCG2 for disorders           About GeneDecksing

    OMIM gene information: 118930    OMIM disorders: --

    20/42 diseases for SCG2 (see all 42):    About MalaCards
    prader-willi syndrome    temporal lobe epilepsy    primitive neuroectodermal tumor    allergic rhinitis
    amyotrophic lateral sclerosis    ganglioneuroma    pituitary adenoma    neuroectodermal tumors
    frontotemporal dementia    lateral sclerosis    neuroendocrine tumor    paraganglioma
    rhinitis    rheumatoid arthritis    ileus    insulinoma
    pick's disease    osteomyelitis    pheochromocytoma    cholera

    10/29 Novoseek disease relationships for SCG2 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 51 19 17102121 (4), 8354485 (3), 10634410 (1), 7641727 (1) (see all 7)
    pituitary adenoma 47.4 5 1552186 (2), 9100282 (2), 1717962 (1)
    carcinoid 47.3 26 9891437 (4), 7607625 (3), 7891024 (2), 7599788 (2) (see all 8)
    ganglioneuroma 43.7 7 8354485 (3), 9754794 (2), 1342950 (1)
    carcinoma neuroendocrine 36 1 9230910 (1)
    neuroendocrine tumors 35.5 1 9100282 (1)
    insulinoma 26.5 4 8617262 (2), 7641727 (2)
    senile plaques 25.7 2 18376054 (1), 2110534 (1)
    aqueous humor 25.5 4 15572199 (2), 8592153 (1)
    ewings sarcoma 24.5 3 1342962 (3)


    Export disorders for SCG2 gene to outside databases

    Publications
    for SCG2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCG2 gene, integrated from 9 sources (see all 215):
    (articles sorted by number of sources associating them with SCG2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Dispersion of chromogranin/secretogranin secretory protein family loci in mammalian genomes. (PubMed id 8617499)1, 3, 9 Mahata S.K....O'Connor D.T. (1996)
    2. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (2006)
    3. Secretoneurin: a new player in angiogenesis and chemotaxis linking nerves, blood vessels and the immune system. (PubMed id 16101435)1, 3 Fischer-Colbrie R....Saria A. (2005)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains. (PubMed id 9654353)1, 2 Leitner B.... Fischer-Colbrie R. (1998)
    7. The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation. (PubMed id 2745426)1, 2 Gerdes H.-H....Huttner W.B. (1989)
    8. Secretogranin II (SgII) distribution and processing studies in human normal and adenomatous anterior pituitaries using new polyclonal antibodies. (PubMed id 9100282)1, 9 Vallet V.S....Duval J. (1997)
    9. Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells. (PubMed id 18239671)1, 9 Li L....Porter A.G. (2008)
    10. Isolation and characterization of the human secretogranin II gene promoter. (PubMed id 10648883)1, 9 Scammell J.G....Ross R.A. (2000)

    External Searches for SCG2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SCG2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7857 HGNC: 10575 AceView: SCG2 Ensembl:ENSG00000171951 euGenes: HUgn7857
    ECgene: SCG2 H-InvDB: SCG2

    Other Databases showing SCG2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SCG2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCG2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SCG2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SCG2 gene:
    Search GeneIP for patents involving SCG2

    GeneCards and IP:
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