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SCG2 Gene

protein-coding   GIFtS: 58
GCID: GC02M224425

Secretogranin II

  See SCG2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secretogranin II1 2 3     EM662
CHGC2 3 5     SN2
secretoneurin1 2     chromogranin-C2
SgII2 3     secretogranin-22
Chromogranin C1     Chromogranin-C3

External Ids:    HGNC: 105751   Entrez Gene: 78572   Ensembl: ENSG000001719517   OMIM: 1189305   UniProtKB: P135213   

Export aliases for SCG2 gene to outside databases

Previous GC identifers: GC02M222484 GC02M223182 GC02M224664 GC02M224287 GC02M224169 GC02M216313


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCG2 Gene:
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory
proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging
or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to
produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose
function is unknown. (provided by RefSeq, Jul 2008)

GeneCards Summary for SCG2 Gene:
SCG2 (secretogranin II) is a protein-coding gene. Diseases associated with SCG2 include silent pituitary adenoma, and ganglioneuroma. GO annotations related to this gene include cytokine activity and chemoattractant activity.

UniProtKB/Swiss-Prot: SCG2_HUMAN, P13521
Function: Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically
active peptides

Gene Wiki entry for SCG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCG2 gene promoter:
         Nkx3-1   Nkx3-1 v4   AP-1   Nkx3-1 v1   Nkx2-5   POU3F2   Nkx3-1 v2   S8   Nkx3-1 v3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCG2 promoter sequence
   Search Chromatin IP Primers for SCG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35-q36   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q35-q36

SCG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCG2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M224425:  view genomic region     (about GC identifiers)

Start:
224,461,658 bp from pter      End:
224,467,221 bp from pter
Size:
5,564 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SCG2_HUMAN, P13521 (See protein sequence)
Recommended Name: Secretogranin-2 precursor  
Size: 617 amino acids; 70941 Da
Miscellaneous: Binds calcium with a low-affinity
Secondary accessions: B2R662 Q53T11 Q8TBH3

Explore the universe of human proteins at neXtProt for SCG2: NX_P13521

Explore proteomics data for SCG2 at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SCG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003460.2  
    ENSEMBL proteins: 
     ENSP00000304133   ENSP00000394702   ENSP00000415468  

    SCG2 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for SCG2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCG2

     
    Search eBioscience for Proteins for SCG2 

    SCG2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for SCG2

    SCG2 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCG2
    Cloud-Clone Corp. CLIAs for SCG2
    Search eBioscience for ELISAs for SCG2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018054 Chromogranin_CS
     IPR001990 Granin

    Graphical View of Domain Structure for InterPro Entry P13521

    ProtoNet protein and cluster: P13521

    1 Blocks protein domain: IPB001990 Chromogranin/secretogranin

    UniProtKB/Swiss-Prot: SCG2_HUMAN, P13521
    Similarity: Belongs to the chromogranin/secretogranin protein family


    Find genes that share domains with SCG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCG2_HUMAN, P13521
    Function: Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically
    active peptides

         Genatlas biochemistry entry for SCG2:
    chromogranin C

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IDA14970115
    GO:0042056chemoattractant activity IDA9473216
         
    Find genes that share ontologies with SCG2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SCG2:
     Decreased viability of wild-ty  Increased S DNA content, incre 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCG2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCG2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCG2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCG2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SCG2:
    hsa-mir-98-5p (MIRT027788)

    Block miRNA regulation of human, mouse, rat SCG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCG2 (see all 10):
    hsa-miR-495 hsa-miR-548am hsa-miR-198 hsa-miR-7-2* hsa-miR-548e hsa-miR-1324 hsa-miR-548a-3p hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidSCG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SCG2
    Predesigned siRNA for gene silencing in human, mouse, rat SCG2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SCG2

    Clone
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    OriGene ORF clones in mouse, rat for SCG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCG2 (NM_003469)
    Sino Biological Human cDNA Clone for SCG2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCG2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SCG2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCG2

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-13877) for SCG2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCG2_HUMAN, P13521: Secreted. Note=Neuroendocrine and endocrine secretory granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA9473216
    GO:0030141secretory granule IEA--

    Find genes that share ontologies with SCG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including SCG2: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SCG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for SCG2 (P135212, 3 ENSP000003041334) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA14970115
    GO:0001525angiogenesis IDA14970115
    GO:0001937negative regulation of endothelial cell proliferation TAS9473216
    GO:0001938positive regulation of endothelial cell proliferation IDA14970115
    GO:0006928cellular component movement IDA9473216

    Find genes that share ontologies with SCG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCG2

    1 HMDB Compound for SCG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for SCG2 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    secretoneurin 99 515 12694392 (11), 12626352 (10), 16904976 (10), 15727576 (10) (see all 83)
    fmlp 43 8 9688329 (2), 9655476 (1), 8878121 (1), 9988125 (1) (see all 5)
    capsaicin 34.3 13 15727576 (3), 15671295 (1), 11245085 (1), 8075827 (1) (see all 6)
    forskolin 31.5 6 9575827 (2), 12969248 (1), 12392156 (1), 10619397 (1)
    polycarbonate 21.3 1 11202062 (1)
    12-o-tetradecanoylphorbol 13-acetate 18.7 2 10619397 (1)
    tyrosine 18.6 10 12392156 (2), 8731045 (2), 15663480 (1), 1601888 (1) (see all 7)
    cyclic amp 18.5 5 10648883 (2), 18239671 (1)
    glycosaminoglycan 17.9 2 7962053 (1)
    dopac 12.8 1 7616217 (1)



    Find genes that share compounds with SCG2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCG2 gene: 
    NM_003469.4  

    Unigene Cluster for SCG2:

    Secretogranin II
    Hs.516726  [show with all ESTs]
    Unigene Representative Sequence: NM_003469
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305409(uc002vnm.3) ENST00000421386 ENST00000433889
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCG2 (see all 10):
    hsa-miR-495 hsa-miR-548am hsa-miR-198 hsa-miR-7-2* hsa-miR-548e hsa-miR-1324 hsa-miR-548a-3p hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidSCG2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SCG2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCG2 (NM_003469)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCG2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SCG2
    OriGene qSTAR qPCR primer pairs in human, mouse for SCG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCG2
      QuantiTect SYBR Green Assays in human, mouse, rat SCG2
      QuantiFast Probe-based Assays in human, mouse, rat SCG2
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-13877) for SCG2 

    Additional mRNA sequence: 

    AK298828.1 AK312452.1 BC022509.1 M25756.1 

    8 DOTS entries:

    DT.455603  DT.100822391  DT.100822395  DT.121000289  DT.121000294  DT.97767691  DT.100822394  DT.86852632 

    Selected AceView cDNA sequences (see all 188):

    CD108215 T08149 CD250914 H54915 AA384796 BG654871 CB157911 BQ776858 
    AI079373 BP374932 CD107534 CA776429 CA843363 CD251718 AV727937 CA843616 
    CB160906 BI792350 CA776351 BX280428 BE549650 BQ007002 BM310607 BQ718355 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SCG2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c
    SP1:              -                           
    SP2:              -     -                     
    SP3:                                          


    ECgene alternative splicing isoforms for SCG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAAACAG
    SCG2 Expression
    About this image


    SCG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    SCG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516726
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SCG2: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SCG2
    OriGene qSTAR qPCR primer pairs in human, mouse for SCG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCG2
    QuantiTect SYBR Green Assays in human, mouse, rat SCG2
    QuantiFast Probe-based Assays in human, mouse, rat SCG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SCG2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scg21 , 5 secretogranin II1, 5 83.2(n)1
    82.11(a)1
      1 (40.89 cM)5
    202541  NM_009129.21  NP_033155.11 
     794346695 
    chicken
    (Gallus gallus)
    Aves SCG21 secretogranin II 67.1(n)
    59.61(a)
      424808  XM_422624.4  XP_422624.3 
    lizard
    (Anolis carolinensis)
    Reptilia SCG26
    secretogranin II
    59(a)
    1 ↔ 1
    3(25167037-25168893)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979392 secretogranin II 72.54(n)    X92873.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scg2b1 secretogranin II (chromogranin C), b 46.75(n)
    33.54(a)
      777641  NM_001077748.1  NP_001071216.1 


    ENSEMBL Gene Tree for SCG2 (if available)
    TreeFam Gene Tree for SCG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCG2 (see all 190)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845670971,2
    --223838964(+) CTTTGG/TCCCCT 1 -- ds50010--------
    rs1420022051,2
    --223838993(+) GGCAAC/TAGCCT 1 -- ds50010--------
    rs1904685931,2
    --223839146(+) TTCTTC/TTACTT 1 -- ds50010--------
    rs1807194621,2
    --223839187(+) CAAAGA/GCTCTA 1 -- ds50010--------
    rs783430331,2
    F--223839366(+) GCTTCG/ATAGAC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1861250281,2
    C--223839467(+) TATAAA/GTAAAA 1 -- ut310--------
    rs1446812071,2
    --223839589(+) TTTTTA/TATCAT 1 -- ut310--------
    rs168649691,2
    C,F,H--223839652(+) TAGATA/TTCTTT 1 -- ut3110Minor allele frequency- T:0.04NA NS EA CSA WA 800
    rs10495771,2
    C,H--223839654(-) AGAAAG/AATATC 1 -- ut313Minor allele frequency- A:0.38MN NS NA 412
    rs1898437541,2
    --223839749(+) GAAGCA/GGACTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SCG2 (224461658 - 224467221 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SCG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834553CNV Gain17160897

    Human Gene Mutation Database (HGMD): SCG2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCG2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118930    OMIM disorders: --

    9 diseases for SCG2:    
    About MalaCards
    silent pituitary adenoma    ganglioneuroma    cholera    phaeochromocytoma
    insulinoma    temporal lobe epilepsy    collagenous colitis    allergic rhinitis
    pheochromocytoma


    Find genes that share disorders with SCG2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SCG2 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 51 19 17102121 (4), 8354485 (3), 10634410 (1), 7641727 (1) (see all 7)
    pituitary adenoma 47.4 5 1552186 (2), 9100282 (2), 1717962 (1)
    carcinoid 47.3 26 9891437 (4), 7607625 (3), 7891024 (2), 7599788 (2) (see all 8)
    ganglioneuroma 43.7 7 8354485 (3), 9754794 (2), 1342950 (1)
    carcinoma neuroendocrine 36 1 9230910 (1)
    neuroendocrine tumors 35.5 1 9100282 (1)
    insulinoma 26.5 4 8617262 (2), 7641727 (2)
    senile plaques 25.7 2 18376054 (1), 2110534 (1)
    aqueous humor 25.5 4 15572199 (2), 8592153 (1)
    ewings sarcoma 24.5 3 1342962 (3)

    Genetic Association Database (GAD): SCG2

    Export disorders for SCG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCG2 gene, integrated from 10 sources (see all 216):
    (articles sorted by number of sources associating them with SCG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dispersion of chromogranin/secretogranin secretory protein family loci in mammalian genomes. (PubMed id 8617499)1, 3, 9 Mahata S.K....O'Connor D.T. (Genomics 1996)
    2. Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study. (PubMed id 20200953)1, 4 Karasik D....Demissie S. (J. Bone Miner. Res. 2010)
    3. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (Pituitary 2006)
    4. Secretoneurin: a new player in angiogenesis and chemotaxis linking nerves, blood vessels and the immune system. (PubMed id 16101435)1, 3 Fischer-Colbrie R....Saria A. (amp 2005)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains. (PubMed id 9654353)1, 2 Leitner B.... Fischer-Colbrie R. (Neurosci. Lett. 1998)
    8. The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation. (PubMed id 2745426)1, 2 Gerdes H.-H....Huttner W.B. (J. Biol. Chem. 1989)
    9. Secretogranin II (SgII) distribution and processing studies in human normal and adenomatous anterior pituitaries using new polyclonal antibodies. (PubMed id 9100282)1, 9 Vallet V.S....Duval J. (Regul. Pept. 1997)
    10. Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells. (PubMed id 18239671)1, 9 Li L....Porter A.G. (Cell Death Differ. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7857 HGNC: 10575 AceView: SCG2 Ensembl:ENSG00000171951 euGenes: HUgn7857
    ECgene: SCG2 H-InvDB: SCG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCG2 gene:
    Search GeneIP for patents involving SCG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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