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Aliases for SCFD2 Gene

Aliases for SCFD2 Gene

  • Sec1 Family Domain Containing 2 2 3
  • Syntaxin-Binding Protein 1-Like 1 3 4
  • STXBP1L1 3 4
  • Sec1 Family Domain-Containing Protein 2 3
  • Syntaxin Binding Protein 1-Like 1 3

External Ids for SCFD2 Gene

Previous GeneCards Identifiers for SCFD2 Gene

  • GC04M053655
  • GC04M053654
  • GC04M053580
  • GC04M053433
  • GC04M049683
  • GC04M053739

Summaries for SCFD2 Gene

GeneCards Summary for SCFD2 Gene

SCFD2 (Sec1 Family Domain Containing 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SCFD2 Gene

  • May be involved in protein transport

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCFD2 Gene

Genomics for SCFD2 Gene

Regulatory Elements for SCFD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCFD2 Gene

52,872,982 bp from pter
53,366,075 bp from pter
493,094 bases
Minus strand

Genomic View for SCFD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCFD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCFD2 Gene

Proteins for SCFD2 Gene

  • Protein details for SCFD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sec1 family domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8N5F3
    • Q8N8H0
    • Q96ED3

    Protein attributes for SCFD2 Gene

    684 amino acids
    Molecular mass:
    75127 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCFD2 Gene


neXtProt entry for SCFD2 Gene

Proteomics data for SCFD2 Gene at MOPED

Post-translational modifications for SCFD2 Gene

  • Ubiquitination at Lys196, Lys424, and Lys664
  • Modification sites at PhosphoSitePlus

Other Protein References for SCFD2 Gene

No data available for DME Specific Peptides for SCFD2 Gene

Domains for SCFD2 Gene

Protein Domains for SCFD2 Gene


Suggested Antigen Peptide Sequences for SCFD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STXBP/unc-18/SEC1 family.
  • Belongs to the STXBP/unc-18/SEC1 family.
genes like me logo Genes that share domains with SCFD2: view

No data available for Gene Families for SCFD2 Gene

Function for SCFD2 Gene

Molecular function for SCFD2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protein transport

Gene Ontology (GO) - Molecular Function for SCFD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SCFD2: view

Phenotypes for SCFD2 Gene

GenomeRNAi human phenotypes for SCFD2:
genes like me logo Genes that share phenotypes with SCFD2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCFD2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCFD2 Gene

Localization for SCFD2 Gene

Subcellular locations from

Jensen Localization Image for SCFD2 Gene COMPARTMENTS Subcellular localization image for SCFD2 gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SCFD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SCFD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SCFD2 Gene

Pathways for SCFD2 Gene

SuperPathways for SCFD2 Gene

No Data Available

Interacting Proteins for SCFD2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000384182 for SCFD2 Gene via STRING

Gene Ontology (GO) - Biological Process for SCFD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006904 vesicle docking involved in exocytosis IEA --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with SCFD2: view

No data available for Pathways by source for SCFD2 Gene

Transcripts for SCFD2 Gene

Unigene Clusters for SCFD2 Gene

Sec1 family domain containing 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCFD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCFD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP2: -

Relevant External Links for SCFD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCFD2 Gene

mRNA expression in normal human tissues for SCFD2 Gene

Protein differential expression in normal tissues for SCFD2 Gene

This gene is overexpressed in Bone (16.5) and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCFD2 Gene

SOURCE GeneReport for Unigene cluster for SCFD2 Gene Hs.302287

genes like me logo Genes that share expressions with SCFD2: view

Expression partners for SCFD2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCFD2 Gene

Orthologs for SCFD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCFD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCFD2 35
  • 88.11 (n)
  • 88.45 (a)
SCFD2 36
  • 88 (a)
(Canis familiaris)
Mammalia SCFD2 35
  • 87.36 (n)
  • 89.17 (a)
SCFD2 36
  • 89 (a)
(Mus musculus)
Mammalia Scfd2 35
  • 84.75 (n)
  • 83.48 (a)
Scfd2 16
Scfd2 36
  • 83 (a)
(Pan troglodytes)
Mammalia SCFD2 35
  • 99.32 (n)
  • 98.83 (a)
SCFD2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Scfd2 35
  • 84.5 (n)
  • 85.09 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
-- 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SCFD2 36
  • 72 (a)
(Gallus gallus)
Aves SCFD2 35
  • 67.52 (n)
  • 65.62 (a)
SCFD2 36
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
-- 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scfd2 35
  • 62.45 (n)
  • 55.17 (a)
(Danio rerio)
Actinopterygii scfd2 35
  • 58.06 (n)
  • 52.71 (a)
scfd2 36
  • 56 (a)
SCFD2 (2 of 2) 36
  • 69 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G42700 35
  • 43.41 (n)
  • 30.22 (a)
(Oryza sativa)
Liliopsida Os11g0169100 35
  • 41.86 (n)
  • 28.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for SCFD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCFD2 Gene

Gene Tree for SCFD2 (if available)
Gene Tree for SCFD2 (if available)

Paralogs for SCFD2 Gene

No data available for Paralogs for SCFD2 Gene

Variants for SCFD2 Gene

Sequence variations from dbSNP and Humsavar for SCFD2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs90020 -- 52,940,144(+) TGCGA(A/G)CTACT intron-variant
rs169960 -- 52,972,080(+) aagac(C/T)atcga intron-variant
rs169961 -- 52,972,211(+) aaagg(C/T)acaga intron-variant
rs301088 -- 52,964,590(+) GGTTC(A/C)AGGTA intron-variant
rs301089 -- 52,965,245(+) CCCCC(A/G)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCFD2 Gene

Variant ID Type Subtype PubMed ID
nsv525346 CNV Loss 19592680
esv2727603 CNV Deletion 23290073
nsv508280 CNV Loss 20534489
esv267413 CNV Insertion 20981092
esv272915 CNV Insertion 20981092
nsv292479 CNV Loss 16902084
esv2727604 CNV Deletion 23290073
esv271316 CNV Insertion 20981092
esv2727605 CNV Deletion 23290073
nsv471810 CNV Loss 16327809
esv1439510 CNV Insertion 17803354
esv2664238 CNV Deletion 23128226
esv24249 CNV Loss 19812545
esv2421791 CNV Deletion 20811451
nsv441876 CNV CNV 18776908
nsv514213 CNV Complex 21397061
nsv4339 CNV Insertion 18451855
nsv879013 CNV Loss 21882294
esv2727606 CNV Deletion 23290073
esv2019878 CNV Deletion 18987734
esv2670287 CNV Deletion 23128226
esv2727608 CNV Deletion 23290073
nsv507167 CNV Insertion 20534489

Relevant External Links for SCFD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCFD2 Gene

Disorders for SCFD2 Gene

Relevant External Links for SCFD2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SCFD2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SCFD2 Gene

Publications for SCFD2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. (PMID: 20395239) Macgregor S. … Mackey D.A. (Hum. Mol. Genet. 2010) 3 48
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SCFD2 Gene

Sources for SCFD2 Gene

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