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Aliases for SCFD1 Gene

Aliases for SCFD1 Gene

  • Sec1 Family Domain Containing 1 2 3
  • Syntaxin-Binding Protein 1-Like 2 3 4
  • C14orf163 3 4
  • STXBP1L2 3 4
  • SLY1P 3 4
  • Sec1 Family Domain-Containing Protein 1 3
  • Chromosome 14 Open Reading Frame 163 2
  • Vesicle Transport-Related Protein 3
  • SLY1 Homolog 4
  • KIAA0917 4
  • RA410 3
  • SLY1 3

External Ids for SCFD1 Gene

Previous Symbols for SCFD1 Gene

  • C14orf163

Summaries for SCFD1 Gene

GeneCards Summary for SCFD1 Gene

SCFD1 (Sec1 Family Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include protein N-terminus binding and syntaxin binding.

UniProtKB/Swiss-Prot for SCFD1 Gene

  • Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).

Gene Wiki entry for SCFD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCFD1 Gene

Genomics for SCFD1 Gene

Genomic Location for SCFD1 Gene

Start:
30,622,112 bp from pter
End:
30,735,828 bp from pter
Size:
113,717 bases
Orientation:
Plus strand

Genomic View for SCFD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCFD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCFD1 Gene

Regulatory Elements for SCFD1 Gene

Proteins for SCFD1 Gene

  • Protein details for SCFD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVM8-SCFD1_HUMAN
    Recommended name:
    Sec1 family domain-containing protein 1
    Protein Accession:
    Q8WVM8
    Secondary Accessions:
    • A8K2Z5
    • B7Z4U7
    • B7Z594
    • O60754
    • O94990
    • Q7Z529
    • Q9BZI3
    • Q9UNL3
    • Q9Y6A8

    Protein attributes for SCFD1 Gene

    Size:
    642 amino acids
    Molecular mass:
    72380 Da
    Quaternary structure:
    • Interacts with STX17. Interacts with STX5A. Interacts with the COG complex via COG4 (By similarity).
    SequenceCaution:
    • Sequence=AAD40381.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAD48586.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAP97146.1; Type=Frameshift; Positions=5; Evidence={ECO:0000305}; Sequence=BAA74940.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SCFD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCFD1 Gene

Proteomics data for SCFD1 Gene at MOPED

Post-translational modifications for SCFD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys63, Lys324, Lys494, and Lys501

No data available for DME Specific Peptides for SCFD1 Gene

Domains for SCFD1 Gene

Protein Domains for SCFD1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SCFD1_HUMAN
Family:
  • Belongs to the STXBP/unc-18/SEC1 family.:
    • Q8WVM8
genes like me logo Genes that share domains with SCFD1: view

No data available for Gene Families for SCFD1 Gene

Function for SCFD1 Gene

Molecular function for SCFD1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).

Gene Ontology (GO) - Molecular Function for SCFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19536132
GO:0019905 syntaxin binding ISS --
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with SCFD1: view
genes like me logo Genes that share phenotypes with SCFD1: view

miRNA for SCFD1 Gene

miRTarBase miRNAs that target SCFD1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCFD1 Gene

Localization for SCFD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCFD1 Gene

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCFD1 Gene COMPARTMENTS Subcellular localization image for SCFD1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 4
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005798 Golgi-associated vesicle ISS --
GO:0005801 cis-Golgi network IDA 15649705
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with SCFD1: view

Pathways for SCFD1 Gene

SuperPathways for SCFD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis ISS --
GO:0001666 response to hypoxia IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER ISS --
GO:0006892 post-Golgi vesicle-mediated transport ISS --
GO:0006904 vesicle docking involved in exocytosis IEA --
genes like me logo Genes that share ontologies with SCFD1: view

No data available for Pathways by source for SCFD1 Gene

Transcripts for SCFD1 Gene

Unigene Clusters for SCFD1 Gene

Sec1 family domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCFD1 Gene

No ASD Table

Relevant External Links for SCFD1 Gene

GeneLoc Exon Structure for
SCFD1
ECgene alternative splicing isoforms for
SCFD1

Expression for SCFD1 Gene

mRNA expression in normal human tissues for SCFD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCFD1 Gene

SOURCE GeneReport for Unigene cluster for SCFD1 Gene Hs.369168

genes like me logo Genes that share expressions with SCFD1: view

Orthologs for SCFD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCFD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCFD1 36
  • 99.95 (n)
  • 100 (a)
SCFD1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCFD1 36
  • 93.9 (n)
  • 97.97 (a)
SCFD1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCFD1 36
  • 94.85 (n)
  • 99.05 (a)
SCFD1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scfd1 36
  • 91.1 (n)
  • 97.46 (a)
Scfd1 16
Scfd1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCFD1 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCFD1 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scfd1 36
  • 90.57 (n)
  • 96.82 (a)
chicken
(Gallus gallus)
Aves SCFD1 36
  • 84.87 (n)
  • 94.11 (a)
SCFD1 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 90 (a)
OneToMany
-- 37
  • 84 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.8397 36
tropical clawed frog
(Silurana tropicalis)
Amphibia scfd1 36
  • 77.11 (n)
  • 90.62 (a)
Str.11932 36
zebrafish
(Danio rerio)
Actinopterygii sly1 36
  • 74.83 (n)
  • 88.24 (a)
sly1 37
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011358 36
  • 51.27 (n)
  • 51.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Slh 36
  • 56.69 (n)
  • 59.55 (a)
Slh 37
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F43D9.3 36
  • 56.17 (n)
  • 50.24 (a)
F43D9.3 37
  • 45 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL120W 36
  • 48.14 (n)
  • 35.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLY1 36
  • 47.69 (n)
  • 34.75 (a)
SLY1 37
  • 32 (a)
OneToOne
SLY1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18480g 36
  • 46.38 (n)
  • 35.45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATSLY1 36
  • 49.34 (n)
  • 40.26 (a)
rice
(Oryza sativa)
Liliopsida Os03g0620800 36
  • 47.02 (n)
  • 41.22 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04252 36
  • 48.94 (n)
  • 41.3 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sly1 36
  • 51.34 (n)
  • 40.13 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14654 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7199 37
  • 58 (a)
OneToOne
Species with no ortholog for SCFD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCFD1 Gene

ENSEMBL:
Gene Tree for SCFD1 (if available)
TreeFam:
Gene Tree for SCFD1 (if available)

Paralogs for SCFD1 Gene

genes like me logo Genes that share paralogs with SCFD1: view

No data available for Paralogs for SCFD1 Gene

Variants for SCFD1 Gene

Sequence variations from dbSNP and Humsavar for SCFD1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs149254 -- 30,650,354(+) GGCCC(A/G/T)ACTCA intron-variant
rs151068 -- 30,632,722(-) TGAGA(A/C)AATCA intron-variant
rs151069 -- 30,633,039(-) CCAGC(A/T)TGCAG intron-variant
rs151070 -- 30,636,734(+) CTTGT(C/T)ataag intron-variant
rs151071 -- 30,636,750(+) tgctt(C/T)ttttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCFD1 Gene

Variant ID Type Subtype PubMed ID
nsv526536 CNV Gain 19592680
esv33189 CNV Loss 17666407
nsv901581 CNV Gain 21882294
nsv84475 CNV Insertion 16902084
nsv84774 CNV Insertion 16902084
nsv1230 CNV Insertion 18451855
nsv509529 CNV Insertion 20534489
esv269610 CNV Insertion 20981092
esv269681 CNV Insertion 20981092
esv1928439 CNV Deletion 18987734

Relevant External Links for SCFD1 Gene

HapMap Linkage Disequilibrium report
SCFD1

Disorders for SCFD1 Gene

Relevant External Links for SCFD1

Genetic Association Database (GAD)
SCFD1
Human Genome Epidemiology (HuGE) Navigator
SCFD1
genes like me logo Genes that share disorders with SCFD1: view

No data available for UniProtKB/Swiss-Prot for SCFD1 Gene

Publications for SCFD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SCFD1 Gene

Sources for SCFD1 Gene

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