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Aliases for SCEL Gene

Aliases for SCEL Gene

  • Sciellin 2 3 5

External Ids for SCEL Gene

Previous GeneCards Identifiers for SCEL Gene

  • GC13P076077
  • GC13P072104
  • GC13P076986
  • GC13P075907
  • GC13P076854
  • GC13P078109
  • GC13P058807

Summaries for SCEL Gene

Entrez Gene Summary for SCEL Gene

  • The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCEL Gene

SCEL (Sciellin) is a Protein Coding gene. An important paralog of this gene is ZNF185.

UniProtKB/Swiss-Prot for SCEL Gene

  • May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.

Gene Wiki entry for SCEL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCEL Gene

Genomics for SCEL Gene

Regulatory Elements for SCEL Gene

Genomic Location for SCEL Gene

Chromosome:
13
Start:
77,535,674 bp from pter
End:
77,645,263 bp from pter
Size:
109,590 bases
Orientation:
Plus strand

Genomic View for SCEL Gene

Genes around SCEL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCEL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCEL Gene

Proteins for SCEL Gene

  • Protein details for SCEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95171-SCEL_HUMAN
    Recommended name:
    Sciellin
    Protein Accession:
    O95171
    Secondary Accessions:
    • B7Z797
    • F5H651
    • Q53H61
    • Q5W0S8
    • Q5W0S9
    • Q86X00

    Protein attributes for SCEL Gene

    Size:
    688 amino acids
    Molecular mass:
    77552 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCEL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCEL Gene

Proteomics data for SCEL Gene at MOPED

Post-translational modifications for SCEL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCEL Gene

No data available for DME Specific Peptides for SCEL Gene

Domains & Families for SCEL Gene

Gene Families for SCEL Gene

Protein Domains for SCEL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCEL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95171

UniProtKB/Swiss-Prot:

SCEL_HUMAN :
  • Contains 1 LIM zinc-binding domain.
Domain:
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with SCEL: view

Function for SCEL Gene

Molecular function for SCEL Gene

GENATLAS Biochemistry:
sciellin,precursor of the cornified envelopes of keratinizing tissues,expressed in the stratum granulosum (in stratified squamous epithelia
UniProtKB/Swiss-Prot Function:
May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.

Gene Ontology (GO) - Molecular Function for SCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14632196
genes like me logo Genes that share ontologies with SCEL: view
genes like me logo Genes that share phenotypes with SCEL: view

Animal Models for SCEL Gene

MGI Knock Outs for SCEL:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCEL Gene

Localization for SCEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCEL Gene

Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCEL Gene COMPARTMENTS Subcellular localization image for SCEL gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS 11112355
genes like me logo Genes that share ontologies with SCEL: view

Pathways & Interactions for SCEL Gene

SuperPathways for SCEL Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 9813070
GO:0009790 embryo development ISS 11112355
genes like me logo Genes that share ontologies with SCEL: view

No data available for Pathways by source and SIGNOR curated interactions for SCEL Gene

Drugs & Compounds for SCEL Gene

No Compound Related Data Available

Transcripts for SCEL Gene

Unigene Clusters for SCEL Gene

Sciellin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCEL Gene

No ASD Table

Relevant External Links for SCEL Gene

GeneLoc Exon Structure for
SCEL
ECgene alternative splicing isoforms for
SCEL

Expression for SCEL Gene

mRNA expression in normal human tissues for SCEL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCEL Gene

This gene is overexpressed in Esophagus - Mucosa (x21.2), Skin - Sun Exposed (Lower leg) (x8.9), Skin - Not Sun Exposed (Suprapubic) (x8.2), and Vagina (x5.8).

Protein differential expression in normal tissues from HIPED for SCEL Gene

This gene is overexpressed in Cervix (45.9) and Saliva (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCEL Gene



SOURCE GeneReport for Unigene cluster for SCEL Gene Hs.534699

mRNA Expression by UniProt/SwissProt for SCEL Gene

O95171-SCEL_HUMAN
Tissue specificity: Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail.
genes like me logo Genes that share expression patterns with SCEL: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SCEL Gene

Orthologs for SCEL Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCEL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCEL 35
  • 85.26 (n)
  • 78.2 (a)
SCEL 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCEL 35
  • 77.59 (n)
  • 69.2 (a)
SCEL 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scel 35
  • 79.25 (n)
  • 71.29 (a)
Scel 16
Scel 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCEL 35
  • 98.89 (n)
  • 98.11 (a)
SCEL 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scel 35
  • 79.68 (n)
  • 72.1 (a)
oppossum
(Monodelphis domestica)
Mammalia SCEL 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCEL 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCEL 35
  • 64.21 (n)
  • 53.02 (a)
SCEL 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCEL 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scel 35
  • 50.75 (n)
  • 37.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15658 35
zebrafish
(Danio rerio)
Actinopterygii scel 36
  • 18 (a)
OneToOne
Species with no ortholog for SCEL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCEL Gene

ENSEMBL:
Gene Tree for SCEL (if available)
TreeFam:
Gene Tree for SCEL (if available)

Paralogs for SCEL Gene

Paralogs for SCEL Gene

genes like me logo Genes that share paralogs with SCEL: view

Variants for SCEL Gene

Sequence variations from dbSNP and Humsavar for SCEL Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_047920 -
VAR_047921 -
rs8002725 - 77,613,943(+) TGTCA(A/G)AAACA intron-variant, reference, missense
rs100270 -- 77,560,900(+) GGACA(C/T)GTCTA intron-variant
rs502613 -- 77,537,139(+) CTAAA(A/T)GTCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCEL Gene

Variant ID Type Subtype PubMed ID
esv2659703 CNV Deletion 23128226
esv271758 CNV Insertion 20981092
esv271294 CNV Insertion 20981092
esv27309 CNV Loss 19812545
esv2677047 CNV Deletion 23128226
esv22418 CNV Loss 19812545

Variation tolerance for SCEL Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.93; 94.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCEL Gene

HapMap Linkage Disequilibrium report
SCEL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCEL Gene

Disorders for SCEL Gene

Relevant External Links for SCEL

Genetic Association Database (GAD)
SCEL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCEL

No disorders were found for SCEL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCEL Gene

Publications for SCEL Gene

  1. cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope. (PMID: 9813070) Champliaud M.-F. … Olson P.F. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress. (PMID: 19211270) Pyle A.L. … Young P.P. (Cardiovasc. Pathol. 2010) 3 23
  3. Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma. (PMID: 15274303) Corona W. … Wadleigh R. (Anticancer Res. 2004) 3 23
  4. The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes. (PMID: 14632196) Champliaud M.F. … Baden H.P. (J. Invest. Dermatol. 2003) 3 23
  5. Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties. (PMID: 11112355) Champliaud M.F. … Viel A. (Genomics 2000) 3 23

Products for SCEL Gene

Sources for SCEL Gene

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