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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCEL Gene

protein-coding GIFtS: 50
GCID: GC13P078109

sciellin

Explore 5 diseases affiliated with
SCEL via

MalaCards

our new
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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sciellin¹
FLJ21667¹
MGC22531¹

External Ids:	HGNC: 10573¹	Entrez Gene: 8796²	Ensembl: ENSG00000136155⁷	OMIM: 604112⁵	UniProtKB: O95171³

Export aliases for SCEL gene to outside databases

Previous GC identifers: GC13P076077 GC13P072104 GC13P076986 GC13P075907 GC13P076854 GC13P058807

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCEL:

The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes.

This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the

cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an

alternative polyA signal has been described in the literature, but its full-length nature has not been determined.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SCEL_HUMAN, O95171

Function: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be

involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope

Gene Wiki entry for SCEL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SCEL gene promoter:
c-Fos AP-1 AML1a ATF-2 CRE-BP1 Cart-1 FOXO1a c-Jun Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCEL promoter sequence

Search SABiosciences Chromatin IP Primers for SCEL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCEL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22 Ensembl cytogenetic band: 13q22.3 HGNC cytogenetic band: 13q22

SCEL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCEL gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P078109: view genomic region (about GC identifiers)

Start:	78,109,809 bp from pter	End:	78,219,398 bp from pter
Size:	109,590 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SCEL_HUMAN, O95171 (See protein sequence)

Recommended Name: Sciellin

Size: 688 amino acids; 77552 Da

Subcellular location: Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase

Secondary accessions: B7Z797 F5H651 Q53H61 Q5W0S8 Q5W0S9 Q86X00

Alternative splicing: 3 isoforms: O95171-1 O95171-2 O95171-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCEL: NX_O95171

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95171

SCEL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001154178.1 NP_003834.3 NP_659001.2

ENSEMBL proteins:

ENSP00000432840 ENSP00000366454 ENSP00000302579 ENSP00000437895

Human Recombinant Protein Products for SCEL:

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	Novus Biologicals SCEL Proteins Novus Biologicals SCEL Lysates
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	Uscn Proteins for SCEL

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001533	cornified envelope	TAS	9813070
GO:0005737	cytoplasm	ISS	11112355
GO:0005886	plasma membrane	IDA	--

SCEL for ontologies About GeneDecksing

SCEL Antibody Products:

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Assay Products for SCEL:

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	GenScript Custom Assay Services for SCEL
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	Uscn ELISAs and CLIAs for SCEL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SCEL for domains About GeneDecksing

1 InterPro domain/family:

IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry O95171

ProtoNet protein and cluster: O95171

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: SCEL_HUMAN, O95171

Similarity: Contains 1 LIM zinc-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SCEL_HUMAN, O95171

Function: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be

involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope

Genatlas biochemistry entry for SCEL:

sciellin,precursor of the cornified envelopes of keratinizing tissues,expressed in the stratum granulosum (in

stratified squamous epithelia

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14632196
GO:0008270	zinc ion binding	IEA	--

SCEL for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Scel):

normal

SCEL for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Scel^tm1Hba for SCEL

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SCEL

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCEL
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate SCEL:
		hsa-miR-203 hsa-miR-875-3p hsa-miR-4282
		SwitchGear 3'UTR luciferase reporter plasmid: SCEL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCEL (see all 7) OriGene shRNA RFP: SCEL OriGene siRNA: SCEL
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		Sirion Biotech Custom design and validation of potent shRNA sequences against SCEL

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SCEL
			Sirion Biotech Customized adenovirus for overexpression of SCEL Sirion Biotech Customized adenovirus for potent knockdown of SCEL

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCEL (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCEL (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SCEL (NM_144777)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCEL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SCEL
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		Sirion Biotech Customized stable knockdown cell line services for SCEL Sirion Biotech Customized inducible knockdown cell line services for SCEL Sirion Biotech Customized stable overexpressing cell line services for SCEL Sirion Biotech Customized inducible overexpressing cell line services for SCEL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCEL

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SCEL

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

4 Interacting proteins for SCEL (O95171^{2, 3} ENSP00000302579⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947²^,³, ENSP00000340989⁴	MINT-3975279 I2D: score=1 STRING: ENSP00000340989
TXNIP	Q9H3M7³, ENSP00000358323⁴	I2D: score=2 STRING: ENSP00000358323
GOLGA2	Q08379³	I2D: score=1
NMI	Q13287³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008544	epidermis development	TAS	9813070
GO:0009790	embryo development	ISS	11112355
GO:0030216	keratinocyte differentiation	IDA	14632196

SCEL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SCEL
Search CenterWatch for drugs/clinical trials and news about SCEL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SCEL gene (3 alternative transcripts):

NM_001160706.1 NM_003843.3 NM_144777.2

Unigene Cluster for SCEL:

Sciellin

Hs.534699 [show with all ESTs]

Unigene Representative Sequence: BC047536

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000471491 ENST00000377246(uc001vkj.3) ENST00000349847 ENST00000469982

ENST00000535157(uc001vki.3 uc010thx.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCEL
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate SCEL:
		hsa-miR-203 hsa-miR-875-3p hsa-miR-4282
		SwitchGear 3'UTR luciferase reporter plasmid: SCEL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCEL (see all 7) OriGene shRNA RFP: SCEL OriGene siRNA: SCEL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCEL
		Sirion Biotech Custom design and validation of potent shRNA sequences against SCEL

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCEL (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCEL (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SCEL (NM_144777)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCEL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCEL

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCEL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SCEL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCEL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCEL

Additional cDNA sequence:

AF045941.1 AK025320.1 AK222720.1 AK301659.1 BC047536.1

14 DOTS entries:

DT.100772592 DT.454129 DT.100772591 DT.97835556 DT.120772163 DT.92047074 DT.100022613 DT.120772147

DT.120772152 DT.120772157 DT.120772160 DT.120772167 DT.95338421 DT.97765736

24/44 AceView cDNA sequences (see all 44):

BM973059 CB265256 AI804274 BC020726 AI623978 AA992192 BM839097 BM955764

AA242761 AU098674 AA242740 AW470178 AA242871 BC047536 AA455011 BQ694222

AF045941 BG528419 BM955765 BG190296 AL602783 BU684595 AA252151 AK025320

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCEL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCTGAAAA

About this image

SCEL expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Respiratory Bronchioles

Basal Cells

Lung

Kidney

S-shaped Body

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SCEL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCEL

SOURCE GeneReport for Unigene cluster: Hs.534699

UniProtKB/Swiss-Prot: SCEL_HUMAN, O95171

Tissue specificity: Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin

stratum spinosum and stratum granulosum, hair follicle and nail

SABiosciences Custom PCR Arrays for SCEL

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCEL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCEL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SCEL gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	SCEL⁶	--	63(a)	1 ↔ 1	3(86244217-86252466)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15658²	Xenopus laevis transcribed sequence with weak similarity more	75.29(n)		BJ062704.1
zebrafish (Danio rerio)	Actinopterygii	scel¹	sciellin	39.98(n) 26.93(a)		368684 NM_001005304.1 NP_001005304.1

ENSEMBL Gene Tree for SCEL (if available)
TreeFam Gene Tree for SCEL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SCEL gene

ZNF185²

SCEL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3812829^1,2	C,F,H	--	78107941(+)	`TCCATA/CAAAAA`	3	--	us2k¹		12		NS EA NA	1934
rs142866952^1,2		--	78107952(+)	`GCTGAG/TTAGAC`	3	--	us2k¹		0	--	--	--	--
rs182111640^1,2		--	78108140(+)	`GTGGGC/TGTCAC`	3	--	us2k¹		0	--	--	--	--
rs73227347^1,2	C,F	--	78108141(+)	`TGGGCG/ATCACT`	3	--	us2k¹		1		NA	120
rs146588134^1,2		--	78108244(+)	`GATGAC/TGTGGC`	3	--	us2k¹		0	--	--	--	--
rs2146877^1,2	C,F,O,H	--	78108335(+)	`GTCCCC/TGCCTA`	3	--	us2k¹		24		NS EA NA CSA WA	2736
rs139908032^1,2		--	78108346(+)	`GAATGG/TCTCTT`	3	--	us2k¹		0	--	--	--	--
rs200825548^1,2		--	78108399(+)	`GTTGG-/TGTTTT`	3	--	us2k¹		0	--	--	--	--
rs77510413^1,2	C	--	78108400(+)	`GTTGGT/GTTTTT`	3	--	us2k¹		9		NA WA CSA EA	369
rs7336362^1,2	C	--	78108411(+)	`tttgtT/Cttttt`	3	--	us2k¹		1		NA	2

HapMap Linkage Disequilibrium report for SCEL (78109809 - 78219398 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SCEL
2 CNVs: 66487 39141
3 Indels: 86917 76421 66488

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCEL

DNA2.0 Custom Variant and Variant Library Synthesis for SCEL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCEL for disorders           About GeneDecksing

OMIM gene information: 604112    OMIM disorders: --

5 diseases for SCEL:    About MalaCards

denys-drash syndrome esophageal squamous cell carcinoma squamous cell carcinoma esophagitis

carcinoma

Export disorders for SCEL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SCEL gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with SCEL)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope. (PubMed id 9813070)^{1, 2, 3, 9} Champliaud M.-F.... Olson P.F. (1998)
Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties. (PubMed id 11112355)^{1, 9} Champliaud M.F....Viel A. (2000)
Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma. (PubMed id 15274303)^{1, 9} Corona W....Wadleigh R. (2004)
The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes. (PubMed id 14632196)^{1, 9} Champliaud M.F....Baden H.P. (2003)
Biomechanical stress induces novel arterial intima-en riched genes: implications for vascular adaptation to stress. (PubMed id 19211270)^{1, 9} Pyle A.L....Young P.P. (2010)
Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes. (PubMed id 1377656)^{1, 9} Kvedar J.C....Baden H.P. (1992)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)² Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8796	HGNC: 10573	AceView: SCEL	Ensembl:ENSG00000136155	euGenes: HUgn8796
ECgene: SCEL	H-InvDB: SCEL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SCEL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SCEL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SCEL gene:
Search GeneIP for patents involving SCEL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for SCEL
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCEL		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCEL
	OriGene Protein Over-expression Lysate for SCEL		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SCEL		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCEL		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCEL
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for SCEL		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SCEL		OriGene Custom Protein Services for SCEL
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCEL
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCEL
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCEL
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCEL
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCEL
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCEL

	GenScript Custom Purified and Recombinant Proteins Services for SCEL		GenScript cDNA clones with any tag delivered in your preferred vector for SCEL
	GenScript Custom Assay Services for SCEL		GenScript Custom Superior Antibodies Services for SCEL
	GenScript Custom overexpressing Cell Line Services for SCEL		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in SCEL promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	SCEL lysates

	Antibodies for SCEL
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Browse ProSpec Recombinant Proteins

SCEL Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SCEL

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCEL

	SwitchGear 3'UTR luciferase reporter plasmids for SCEL
	SwitchGear Promoter luciferase reporter plasmids for SCEL

Search ThermoFisher Antibodies for SCEL

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCEL

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SCEL

Sirion Biotech Customized:

	stable knockdown cell line services for SCEL
	inducible knockdown cell line services for SCEL
	design and validation of potent shRNA sequences against SCEL
	adenovirus for potent knockdown of SCEL
	adenovirus for overexpression of SCEL
	stable overexpressing cell line services for SCEL
	inducible overexpressing cell line services for SCEL

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SCEL gene at Home site.

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SCEL Gene

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SCEL Gene

sciellin

Aliasesfor SCEL gene

Summariesfor SCEL gene

Genomic Viewsfor SCEL gene

Proteinsfor SCEL gene

Protein Domains /Familiesfor SCEL gene

Functionfor SCEL gene

Pathways & Interactionsfor SCEL gene

Drugs & Compoundsfor SCEL gene

Transcriptsfor SCEL gene

Expression for SCEL gene

Orthologsfor SCEL gene

Paralogsfor SCEL gene

Genomic Variantsfor SCEL gene

Disorders / Diseasesfor SCEL gene

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External Searches for SCEL gene

Genome Databases showing SCEL gene

Other Databases showing SCEL gene

Specialized Databases showing SCEL gene

Intellectual Propertyfor SCEL gene

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View Random Gene

Aliases
for SCEL gene

Summaries
for SCEL gene

Genomic Views
for SCEL gene

Proteins
for SCEL gene

Protein Domains /
Families
for SCEL gene

Function
for SCEL gene

Pathways & Interactions
for SCEL gene

Drugs & Compounds
for SCEL gene

Transcripts
for SCEL gene

Expression
for SCEL gene

Orthologs
for SCEL gene

Paralogs
for SCEL gene

Genomic Variants
for SCEL gene

Disorders / Diseases
for SCEL gene

Publications
for SCEL gene

Intellectual Property
for SCEL gene

Products
for SCEL gene