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SCEL Gene

protein-coding   GIFtS: 51
GCID: GC13P078109

Sciellin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
sciellin1 2

External Ids:    HGNC: 105731   Entrez Gene: 87962   Ensembl: ENSG000001361557   OMIM: 6041125   UniProtKB: O951713   

Export aliases for SCEL gene to outside databases

Previous GC identifers: GC13P076077 GC13P072104 GC13P076986 GC13P075907 GC13P076854 GC13P058807


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCEL Gene:
The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated
keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of
proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant
utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not
been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for SCEL Gene:
SCEL (sciellin) is a protein-coding gene. An important paralog of this gene is ZNF185.

UniProtKB/Swiss-Prot: SCEL_HUMAN, O95171
Function: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be
involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope

Gene Wiki entry for SCEL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCEL gene promoter:
         c-Fos   AP-1   AML1a   ATF-2   CRE-BP1   Cart-1   FOXO1a   c-Jun   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCEL promoter sequence
   Search Chromatin IP Primers for SCEL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCEL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22   Ensembl cytogenetic band:  13q22.3   HGNC cytogenetic band: 13q22

SCEL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCEL gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P078109:  view genomic region     (about GC identifiers)

Start:
78,109,809 bp from pter      End:
78,219,398 bp from pter
Size:
109,590 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SCEL_HUMAN, O95171 (See protein sequence)
Recommended Name: Sciellin  
Size: 688 amino acids; 77552 Da
Secondary accessions: B7Z797 F5H651 Q53H61 Q5W0S8 Q5W0S9 Q86X00
Alternative splicing: 3 isoforms:  O95171-1   O95171-2   O95171-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCEL: NX_O95171

Explore proteomics data for SCEL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SCEL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001154178.1  NP_003834.3  NP_659001.2  

    ENSEMBL proteins: 
     ENSP00000432840   ENSP00000366454   ENSP00000302579   ENSP00000437895  

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    antibodies-online proteins for SCEL (5 products) 

     
    antibodies-online peptides for SCEL

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    antibodies-online antibodies for SCEL (29 products) 

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    antibodies-online kits for SCEL (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry O95171

    ProtoNet protein and cluster: O95171

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: SCEL_HUMAN, O95171
    Similarity: Contains 1 LIM zinc-binding domain


    Find genes that share domains with SCEL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCEL_HUMAN, O95171
    Function: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be
    involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope

         Genatlas biochemistry entry for SCEL:
    sciellin,precursor of the cornified envelopes of keratinizing tissues,expressed in the stratum granulosum (in
    stratified squamous epithelia

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14632196
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with SCEL           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Scel):
     normal 

    Find genes that share phenotypes with SCEL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sceltm1Hba for SCEL

       genOway: Develop your customized and physiologically relevant rodent model for SCEL

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCEL_HUMAN, O95171: Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane4
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope TAS9813070
    GO:0005737cytoplasm ISS11112355
    GO:0005886plasma membrane ----
    GO:0016020membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SCEL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCEL
    Interactions:

        Search GeneGlobe Interaction Network for SCEL

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SCEL (O951712, 3 ENSP000003025794) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3, ENSP000003409894MINT-3975279 I2D: score=1 STRING: ENSP00000340989
    TXNIPQ9H3M73, ENSP000003583234I2D: score=2 STRING: ENSP00000358323
    GOLGA2Q083793I2D: score=1 
    NMIQ132873I2D: score=1 
    ARHGAP27ENSP000003661214STRING: ENSP00000366121
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008544epidermis development TAS9813070
    GO:0009790embryo development ISS11112355
    GO:0030216keratinocyte differentiation IDA14632196

    Find genes that share ontologies with SCEL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCEL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCEL gene (3 alternative transcripts): 
    NM_001160706.1  NM_003843.3  NM_144777.2  

    Unigene Cluster for SCEL:

    Sciellin
    Hs.534699  [show with all ESTs]
    Unigene Representative Sequence: BC047536
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471491 ENST00000377246(uc001vkj.3) ENST00000349847 ENST00000469982
    ENST00000535157(uc001vki.3 uc010thx.2)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate SCEL:
    hsa-miR-203 hsa-miR-875-3p hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidSCEL 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF045941.1 AK025320.1 AK222720.1 AK301659.1 BC047536.1 

    14 DOTS entries:

    DT.100772592  DT.454129  DT.100772591  DT.97835556  DT.120772163  DT.92047074  DT.100022613  DT.120772147 
    DT.120772152  DT.120772157  DT.120772160  DT.120772167  DT.95338421  DT.97765736 

    Selected AceView cDNA sequences (see all 44):

    AI804274 CB265256 BM955764 AA242761 BC020726 AA992192 AI623978 BM839097 
    BM973059 BM955765 BU684595 BG190296 BG209627 BC047536 NM_144777 AL602783 
    AA242740 BQ694222 AF045941 BX477739 AA455011 BX095638 AA242871 AW470178 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCEL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTGAAAA
    SCEL Expression
    About this image


    SCEL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
     
     Esophagus (Gastrointestinal Tract)
    SCEL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCEL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534699

    UniProtKB/Swiss-Prot: SCEL_HUMAN, O95171
    Tissue specificity: Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue,
    foreskin stratum spinosum and stratum granulosum, hair follicle and nail

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SCEL gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scel1 , 5 sciellin1, 5 79.25(n)1
    71.29(a)1
      14 (52.51 cM)5
    649291  NM_022886.21  NP_075024.21 
     1035133415 
    chicken
    (Gallus gallus)
    Aves SCEL1 sciellin 64.21(n)
    53.02(a)
      101751260  XM_004938619.1  XP_004938676.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCEL6
    sciellin
    63(a)
    1 ↔ 1
    3(86240670-86339102)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.156582 Xenopus laevis transcribed sequence with weak similarity more 75.29(n)    BJ062704.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scel6
    sciellin
    18(a)
    1 ↔ 1
    9(17822380-17850876) ENSDARG00000034677


    ENSEMBL Gene Tree for SCEL (if available)
    TreeFam Gene Tree for SCEL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCEL gene
    ZNF1852  

    Find genes that share paralogs with SCEL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCEL (see all 2114)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38128291,2
    C,F,H--78107941(+) TCCATA/CAAAAA 3 -- us2k112Minor allele frequency- C:0.04NS EA NA 1934
    rs1428669521,2
    --78107952(+) GCTGAG/TTAGAC 3 -- us2k10--------
    rs1821116401,2
    --78108140(+) GTGGGC/TGTCAC 3 -- us2k10--------
    rs732273471,2
    C,F--78108141(+) TGGGCG/ATCACT 3 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1465881341,2
    C--78108244(+) GATGAC/TGTGGC 3 -- us2k10--------
    rs21468771,2
    C,F,O,H--78108335(+) GTCCCC/TGCCTA 3 -- us2k124Minor allele frequency- T:0.08NS EA NA CSA WA 2736
    rs1399080321,2
    --78108346(+) GAATGG/TCTCTT 3 -- us2k10--------
    rs2008255481,2
    C--78108399(+) GTTGG-/TGTTTT 3 -- us2k10--------
    rs5236741,2
    C,H--78108400(+) GTTGGT/GTTTTT 3 -- us2k111Minor allele frequency- G:0.03NA WA CSA EA 373
    rs73363621,2
    C--78108411(+) tttgtT/Cttttt 3 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for SCEL (78109809 - 78219398 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SCEL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677047CNV Deletion23128226
    esv2659703CNV Deletion23128226
    esv271294CNV Insertion20981092
    esv271758CNV Insertion20981092
    esv22418CNV Loss19812545
    esv27309CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCEL
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604112    OMIM disorders: --


    Find genes that share disorders with SCEL           About GenesLikeMe

    Genetic Association Database (GAD): SCEL

    Export disorders for SCEL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCEL gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SCEL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope. (PubMed id 9813070)1, 2, 3, 9 Champliaud M.-F.... Olson P.F. (J. Biol. Chem. 1998)
    2. Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties. (PubMed id 11112355)1, 9 Champliaud M.F....Viel A. (Genomics 2000)
    3. Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma. (PubMed id 15274303)1, 9 Corona W....Wadleigh R. (Anticancer Res. 2004)
    4. The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes. (PubMed id 14632196)1, 9 Champliaud M.F....Baden H.P. (J. Invest. Dermatol. 2003)
    5. Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress. (PubMed id 19211270)1, 9 Pyle A.L....Young P.P. (Cardiovasc. Pathol. 2010)
    6. Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes. (PubMed id 1377656)1, 9 Kvedar J.C....Baden H.P. ( research in biological diversity 1992)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8796 HGNC: 10573 AceView: SCEL Ensembl:ENSG00000136155 euGenes: HUgn8796
    ECgene: SCEL H-InvDB: SCEL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SCEL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCEL gene:
    Search GeneIP for patents involving SCEL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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