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Aliases for SCD5 Gene

Aliases for SCD5 Gene

  • Stearoyl-CoA Desaturase 5 2 3
  • Stearoyl-CoA Desaturase 4 2 3
  • Stearoyl-CoA 9-Desaturase 3 4
  • Stearoyl-CoA Desaturase 2 3 4
  • Acyl-CoA-Desaturase 4 3 4
  • EC 1.14.19.1 4 63
  • ACOD4 3 4
  • HSCD5 3 4
  • SCD4 3 4
  • SCD2 3 4
  • FADS4 3

External Ids for SCD5 Gene

Previous HGNC Symbols for SCD5 Gene

  • SCD4

Previous GeneCards Identifiers for SCD5 Gene

  • GC04M083910
  • GC04M083770
  • GC04M083550
  • GC04M079292

Summaries for SCD5 Gene

Entrez Gene Summary for SCD5 Gene

  • Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SCD5 Gene

SCD5 (Stearoyl-CoA Desaturase 5) is a Protein Coding gene. Diseases associated with SCD5 include obesity. Among its related pathways are PPAR signaling pathway and AMPK signaling pathway. GO annotations related to this gene include iron ion binding and stearoyl-CoA 9-desaturase activity. An important paralog of this gene is SCD.

UniProtKB/Swiss-Prot for SCD5 Gene

  • Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:15610069). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCD5 Gene

Genomics for SCD5 Gene

Regulatory Elements for SCD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCD5 Gene

Chromosome:
4
Start:
82,629,537 bp from pter
End:
82,798,857 bp from pter
Size:
169,321 bases
Orientation:
Minus strand

Genomic View for SCD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCD5 Gene

Proteins for SCD5 Gene

  • Protein details for SCD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SK9-SCD5_HUMAN
    Recommended name:
    Stearoyl-CoA desaturase 5
    Protein Accession:
    Q86SK9
    Secondary Accessions:
    • B2RPG0
    • Q4W5Q5
    • Q8NDS0
    • Q9H7D1

    Protein attributes for SCD5 Gene

    Size:
    330 amino acids
    Molecular mass:
    37610 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Expected to bind 2 Fe(2+) ions per subunit.;
    Quaternary structure:
    • May self-associate and form homodimers.

    Alternative splice isoforms for SCD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCD5 Gene

Proteomics data for SCD5 Gene at MOPED

Selected DME Specific Peptides for SCD5 Gene

Post-translational modifications for SCD5 Gene

  • Ubiquitination at Lys 17 and Lys 136
  • Modification sites at PhosphoSitePlus

Other Protein References for SCD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SCD5 Gene

Gene Families for SCD5 Gene

Suggested Antigen Peptide Sequences for SCD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SK9

UniProtKB/Swiss-Prot:

SCD5_HUMAN :
  • The histidine box domains are involved in binding the catalytic metal ions.
  • Belongs to the fatty acid desaturase family.
Domain:
  • The histidine box domains are involved in binding the catalytic metal ions.
Family:
  • Belongs to the fatty acid desaturase family.
genes like me logo Genes that share domains with SCD5: view

Function for SCD5 Gene

Molecular function for SCD5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:15610069). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids.

Enzyme Numbers (IUBMB) for SCD5 Gene

Gene Ontology (GO) - Molecular Function for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004768 stearoyl-CoA 9-desaturase activity IDA 15907797
GO:0016491 oxidoreductase activity IDA 15907797
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SCD5: view
genes like me logo Genes that share phenotypes with SCD5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCD5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SCD5 Gene

Localization for SCD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCD5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCD5 Gene COMPARTMENTS Subcellular localization image for SCD5 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 15907797
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCD5: view

Pathways & Interactions for SCD5 Gene

genes like me logo Genes that share pathways with SCD5: view

Pathways by source for SCD5 Gene

Interacting Proteins for SCD5 Gene

Gene Ontology (GO) - Biological Process for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006636 unsaturated fatty acid biosynthetic process IDA 15907797
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SCD5: view

No data available for SIGNOR curated interactions for SCD5 Gene

Drugs & Compounds for SCD5 Gene

(3) Drugs for SCD5 Gene - From: ApexBio and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
MK-8245 Pharma SCD inhibitor,potent and liver-selective 0
histidine Nutra 31

(8) Additional Compounds for SCD5 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Oleoyl-CoA
  • Octadecenoyl-CoA (n-C18:1CoA)
  • Oleoyl-Coa
1716-06-9
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
stearoyl-coa
  • Octadecanoyl-CoA
  • Octadecanoyl-coenzyme A
  • S-Octadecanoate
  • S-Octadecanoate CoA
  • S-Octadecanoate Coenzyme A
362-66-3
genes like me logo Genes that share compounds with SCD5: view

Transcripts for SCD5 Gene

mRNA/cDNA for SCD5 Gene

Unigene Clusters for SCD5 Gene

Stearoyl-CoA desaturase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCD5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - -
SP3:
SP4: - - - -

Relevant External Links for SCD5 Gene

GeneLoc Exon Structure for
SCD5
ECgene alternative splicing isoforms for
SCD5

Expression for SCD5 Gene

mRNA expression in normal human tissues for SCD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCD5 Gene

This gene is overexpressed in Brain - Amygdala (x4.6), Brain - Spinal cord (cervical c-1) (x4.3), and Brain - Substantia nigra (x4.3).

Protein differential expression in normal tissues from HIPED for SCD5 Gene

This gene is overexpressed in Frontal cortex (11.7), Fetal Brain (9.7), Fetal testis (9.1), Islet of Langerhans (8.8), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCD5 Gene



SOURCE GeneReport for Unigene cluster for SCD5 Gene Hs.379191

mRNA Expression by UniProt/SwissProt for SCD5 Gene

Q86SK9-SCD5_HUMAN
Tissue specificity: Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung.
genes like me logo Genes that share expression patterns with SCD5: view

Protein tissue co-expression partners for SCD5 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for SCD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCD5 36
  • 100 (a)
OneToOne
SCD5 35
  • 99.49 (n)
  • 99.7 (a)
oppossum
(Monodelphis domestica)
Mammalia SCD5 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCD5 36
  • 86 (a)
OneToOne
SCD5 35
  • 91.2 (n)
  • 89.13 (a)
cow
(Bos Taurus)
Mammalia SCD5 36
  • 87 (a)
OneToOne
SCD5 35
  • 88.08 (n)
  • 89.09 (a)
chicken
(Gallus gallus)
Aves SCD5 35
  • 81.95 (n)
  • 87.35 (a)
zebrafish
(Danio rerio)
Actinopterygii scd 35
  • 68.76 (n)
  • 70.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fad2 36
  • 39 (a)
ManyToMany
desat2 36
  • 43 (a)
ManyToMany
desat1 36
  • 40 (a)
ManyToMany
CG9747 36
  • 29 (a)
ManyToMany
CG9743 36
  • 35 (a)
ManyToMany
CG8630 36
  • 37 (a)
ManyToMany
CG15531 36
  • 23 (a)
ManyToMany
desat1 35
  • 60.73 (n)
  • 53.08 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001713 35
  • 60.27 (n)
  • 56.16 (a)
worm
(Caenorhabditis elegans)
Secernentea fat-7 36
  • 42 (a)
ManyToMany
fat-6 36
  • 43 (a)
ManyToMany
fat-5 36
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLE1 36
  • 18 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06100 35
  • 44.95 (n)
  • 34.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9947 36
  • 47 (a)
ManyToMany
CSA.9813 36
  • 50 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
Species with no ortholog for SCD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCD5 Gene

ENSEMBL:
Gene Tree for SCD5 (if available)
TreeFam:
Gene Tree for SCD5 (if available)

Paralogs for SCD5 Gene

Paralogs for SCD5 Gene

(1) SIMAP similar genes for SCD5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCD5: view

Variants for SCD5 Gene

Structural Variations from Database of Genomic Variants (DGV) for SCD5 Gene

Variant ID Type Subtype PubMed ID
nsv829989 CNV Loss 17160897
nsv879511 CNV Loss 21882294
esv8610 CNV Loss 19470904
esv2656999 CNV Deletion 23128226
nsv292149 CNV Loss 16902084
nsv517479 CNV Loss 19592680
esv2662825 CNV Deletion 23128226
esv29299 CNV Loss 19812545
esv2421771 CNV Deletion 20811451
nsv818247 CNV Loss 17921354
nsv441894 CNV CNV 18776908
nsv514228 CNV Loss 21397061
nsv524141 CNV Gain 19592680
nsv291633 CNV Loss 16902084

Variation tolerance for SCD5 Gene

Residual Variation Intolerance Score: 31.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCD5 Gene

HapMap Linkage Disequilibrium report
SCD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SCD5 Gene

Disorders for SCD5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCD5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association
Search SCD5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCD5

Genetic Association Database (GAD)
SCD5
Human Genome Epidemiology (HuGE) Navigator
SCD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCD5
genes like me logo Genes that share disorders with SCD5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCD5 Gene

Publications for SCD5 Gene

  1. Identification and characterization of hamster stearoyl-CoA desaturase isoforms. (PMID: 18084785) Wang J. … Qian Y. (Lipids 2008) 23 67
  2. Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5. (PMID: 17468887) Lengi A.J. … Corl B.A. (Lipids 2007) 23 67
  3. Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation. (PMID: 17391062) Binczek E. … Stoffel W. (Biol. Chem. 2007) 23 67
  4. Gene expression in human cumulus cells: one approach to oocyte competence. (PMID: 17951581) Feuerstein P. … Royere D. (Hum. Reprod. 2007) 23 67
  5. Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. (PMID: 16385447) Sparrow D.B. … Dunwoodie S.L. (Am. J. Hum. Genet. 2006) 23 67

Products for SCD5 Gene

Sources for SCD5 Gene

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