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SCD5 Gene

protein-coding   GIFtS: 58
GCID: GC04M083550

Stearoyl-CoA Desaturase 5

(Previous name: stearoyl-CoA desaturase 4)
(Previous symbol: SCD4)
  See SCD5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stearoyl-CoA Desaturase 51 2     Stearoyl-CoA 9-Desaturase2 3
SCD41 2 3 5     HSCD52 3
ACOD42 3 5     EC 1.14.19.13 8
Stearoyl-CoA Desaturase 41 2     FADS42
Acyl-CoA-Desaturase 42 3     SCD22

External Ids:    HGNC: 210881   Entrez Gene: 799662   Ensembl: ENSG000001452847   OMIM: 6083705   UniProtKB: Q86SK93   

Export aliases for SCD5 gene to outside databases

Previous GC identifers: GC04M083910 GC04M083770 GC04M079292


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCD5 Gene:
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that
catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of
energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been
identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human.
SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In
contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al.,
2005 (PubMed 15907797)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SCD5 Gene:
SCD5 (stearoyl-CoA desaturase 5) is a protein-coding gene. Diseases associated with SCD5 include spondylocostal dysostosis, and obesity. GO annotations related to this gene include stearoyl-CoA 9-desaturase activity and iron ion binding. An important paralog of this gene is SCD.

UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9
Function: Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9
position




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCD5 gene promoter:
         Nkx3-1 v4   AML1a   NF-AT   NF-AT4   NF-AT2   FOXJ2 (long isoform)   Nkx3-1 v3   NF-AT3   FOXJ2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCD5 promoter sequence
   Search Chromatin IP Primers for SCD5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.22   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21.3

SCD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCD5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M083550:  view genomic region     (about GC identifiers)

Start:
83,550,690 bp from pter      End:
83,720,010 bp from pter
Size:
169,321 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9 (See protein sequence)
Recommended Name: Stearoyl-CoA desaturase 5  
Size: 330 amino acids; 37610 Da
Cofactor: Iron (By similarity)
Secondary accessions: B2RPG0 Q4W5Q5 Q8NDS0 Q9H7D1
Alternative splicing: 2 isoforms:  Q86SK9-1   Q86SK9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCD5: NX_Q86SK9

Explore proteomics data for SCD5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys17, Lys136
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SCD5 (Q86SK9) (see all 6)
     TDADPHN  PTLVPWY  RDHRAHH  LVNSAAH 


    See SCD5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032671.2  NP_079182.2  

    ENSEMBL proteins: 
     ENSP00000316329   ENSP00000273908   ENSP00000282709  

    SCD5 Human Recombinant Protein Products:

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    Novus Biologicals SCD5 Lysate
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    Cloud-Clone Corp. Proteins for SCD5

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FADS: Fatty acid desaturases

    3 InterPro protein domains:
     IPR015876 Fatty_acid_desaturase-1_core
     IPR001522 Fatty_acid_desaturase-1_C
     IPR005804 Fatty_acid_desaturase-1

    Graphical View of Domain Structure for InterPro Entry Q86SK9

    ProtoNet protein and cluster: Q86SK9

    1 Blocks protein domain: IPB001522 Fatty acid desaturase

    UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9
    Domain: The histidine box domains may contain the active site and/or be involved in metal ion binding (By
    similarity)
    Similarity: Belongs to the fatty acid desaturase family


    Find genes that share domains with SCD5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCD5_HUMAN, Q86SK9
    Function: Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9
    position
    Catalytic activity: Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2
    H(2)O

         Enzyme Number (IUBMB): EC 1.14.19.11 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004768stearoyl-CoA 9-desaturase activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0016717oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water ----
         
    Find genes that share ontologies with SCD5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SCD5:
     Decreased viability of wild-ty  High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCD5
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    miRNA
    Products:
        
    miRTarBase miRNAs that target SCD5:
    hsa-mir-92a-3p (MIRT049021), hsa-mir-30c-5p (MIRT047892), hsa-mir-140-3p (MIRT021675), hsa-mir-324-5p (MIRT043059)

    Block miRNA regulation of human, mouse, rat SCD5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCD5 (see all 62):
    hsa-miR-194* hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-411 hsa-miR-548k hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidSCD5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SCD5
    Predesigned siRNA for gene silencing in human, mouse, rat SCD5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SCD5 (NM_024906)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCD5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SCD5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCD5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCD5_HUMAN, Q86SK9: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    peroxisome2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SCD5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SCD5 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    oleate biosynthesis II (animals)0.32
    2Fatty acid metabolism
    Fatty acid metabolism0.42
    3PPAR signaling pathway
    PPAR signaling pathway


    Find genes that share SuperPaths with SCD5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SCD5
        oleate biosynthesis II (animals)


    3 Kegg Pathways  (Kegg details for SCD5):
        Biosynthesis of unsaturated fatty acids
    Fatty acid metabolism
    PPAR signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCD5
    Interactions:

        GeneGlobe Interaction Network for SCD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SCD5 (Q86SK93 ENSP000003163294) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319473I2D: score=1 
    ACOT4ENSP000003230714STRING: ENSP00000323071
    UBE2G2ENSP000003383484STRING: ENSP00000338348
    NPLOC4ENSP000003314874STRING: ENSP00000331487
    FAF2ENSP000002619424STRING: ENSP00000261942
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006633fatty acid biosynthetic process IEA--

    Find genes that share ontologies with SCD5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCD5

    5 HMDB Compounds for SCD5    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--
    Oleoyl-CoAOleoyl-Coa 1716-06-9--
    OxygenOxygen (see all 5)7782-44-7--
    Stearoyl-CoAOctadecanoyl-CoA (see all 16)362-66-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 Novoseek inferred chemical compound relationships for SCD5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ibmx 52.6 1 10946019 (1)
    histidine 33.3 1 17468887 (1)
    lipid 30.9 1 10946019 (1)
    dexamethasone 23.8 1 10946019 (1)



    Find genes that share compounds with SCD5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCD5 gene (2 alternative transcripts): 
    NM_001037582.2  NM_024906.2  

    Unigene Cluster for SCD5:

    Stearoyl-CoA desaturase 5
    Hs.379191  [show with all ESTs]
    Unigene Representative Sequence: NM_001037582
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319540(uc003hna.2) ENST00000273908(uc003hnb.4) ENST00000282709(uc003hnc.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCD5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCD5 (see all 62):
    hsa-miR-194* hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-411 hsa-miR-548k hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidSCD5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SCD5
    Predesigned siRNA for gene silencing in human, mouse, rat SCD5
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SCD5 (NM_024906)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCD5
    Primer
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    OriGene qPCR primer pairs and template standards for SCD5
    OriGene qSTAR qPCR primer pairs in human, mouse for SCD5
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SCD5
      QuantiTect SYBR Green Assays in human, mouse, rat SCD5
      QuantiFast Probe-based Assays in human, mouse, rat SCD5

    Additional mRNA sequence: 

    AF389338.1 AK024685.1 AL831891.1 BC004936.1 BC048971.1 BC137429.1 BC137432.1 

    11 DOTS entries:

    DT.317674  DT.95242421  DT.92425447  DT.99961670  DT.92425446  DT.95242401  DT.95242423  DT.100699976 
    DT.121233270  DT.91840145  DT.95242404 

    Selected AceView cDNA sequences (see all 255):

    CR601926 AI262177 BC004936 BU620577 H88534 AI815927 AW264140 CK905449 
    N45466 T32057 AA293039 AA781761 BQ575927 AI124706 AI401562 CR621321 
    AI625601 BM722138 Z44301 CR621269 AV708127 CB241958 AF389338 BM687841 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SCD5    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                -     -           -               
    SP2:                                -     -                           
    SP3:                                                                  
    SP4:                                -     -     -     -               


    ECgene alternative splicing isoforms for SCD5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAATTAAT
    SCD5 Expression
    About this image


    SCD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Ovary (Reproductive System)
     
     Adrenal Gland (Endocrine System)
    SCD5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCD5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.379191

    UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9
    Tissue specificity: Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and
    pancreas, and at lower levels in kidney and lung

        Custom PCR Arrays for SCD5
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SCD5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SCD5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia SCD51 stearoyl-CoA desaturase 5 91.2(n)
    89.13(a)
      487831  XM_544953.4  XP_544953.2 
    chicken
    (Gallus gallus)
    Aves SCD51 stearoyl-CoA desaturase 5 81.95(n)
    87.35(a)
      422598  XM_420557.4  XP_420557.4 
    zebrafish
    (Danio rerio)
    Actinopterygii scd1 stearoyl-CoA desaturase (delta-9-desaturase) 68.76(n)
    70.38(a)
      386661  XM_005173002.1  XP_005173059.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta desat11 desat1 60.73(n)
    53.08(a)
      117369  NM_169468.1  NP_731712.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fat-66
    fat-76
    (see all 3)
    Protein FAT-7 (fat-7) mRNA, complete cds
    (see all 3)
    43(a)
    42(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(11913690-11917340) WBGene00001398
    V(7151356-7153146) WBGene00001399
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OLE16
    Delta(9) fatty acid desaturase, required for monou...
    18(a)
    1 → many
    VII(398628-400160) YGL055W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G061001 AT1G06100 44.95(n)
    34.85(a)
      837119  NM_100491.1  NP_172100.1 


    ENSEMBL Gene Tree for SCD5 (if available)
    TreeFam Gene Tree for SCD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCD5 gene
    SCD2  
    1 SIMAP similar gene for SCD5 using alignment to 3 protein entries:     SCD5_HUMAN (see all proteins):
    SCD

    Find genes that share paralogs with SCD5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCD5 (see all 3751)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339458381,2
    C--79312705(+) TAACT-/GTATTTT 1 -- int11Minor allele frequency- GT:0.00NA 2
    rs106328131,2
    C--83415774(+) AGAAA-/GA    
       A
    /GAG
    AGAAA
    4 -- cds1 trp30--------
    rs1494074371,2
    C--83550201(+) GACACA/GTTAAG 1 -- int10--------
    rs46934711,2
    C,F,A,H--83550210(+) AGAAGT/CTTCTA 1 -- int121Minor allele frequency- C:0.40NA NS EA WA 1334
    rs1862462861,2
    --83550306(+) TAGAGG/TGAAAA 1 -- int10--------
    rs769499911,2
    C,F--83550315(+) AACAGG/AAGTCC 1 -- int13Minor allele frequency- A:0.04CSA WA NA 239
    rs1149138871,2
    F--83550392(+) GGGTGA/GCATAT 1 -- int11Minor allele frequency- G:0.01WA 118
    rs799491431,2
    C,F--83550404(+) GGAGTA/TGATTC 1 -- int11Minor allele frequency- T:0.20WA 118
    rs76705151,2
    C,F,H--83550413(+) TCCCAT/ATTATC 1 -- int199Minor allele frequency- A:0.37NS NA EA PA EU CA WA CSA 4886
    rs76758871,2
    C,F,A,H--83550606(+) CAATGC/TGAGTC 1 -- int1107Minor allele frequency- T:0.36NS NA EA PA EU CA WA CSA 6440

    HapMap Linkage Disequilibrium report for SCD5 (83550690 - 83720010 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SCD5 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2421771CNV Deletion20811451
    esv2662825CNV Deletion23128226
    esv2656999CNV Deletion23128226
    esv29299CNV Loss19812545
    nsv292149CNV Loss16902084
    nsv517479CNV Loss19592680
    nsv291633CNV Loss16902084
    nsv829989CNV Loss17160897
    nsv818247CNV Loss17921354
    esv8610CNV Loss19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCD5
    DNA2.0 Custom Variant and Variant Library Synthesis for SCD5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608370    OMIM disorders: --

    2 diseases for SCD5:    
    About MalaCards
    spondylocostal dysostosis    obesity


    Find genes that share disorders with SCD5           About GenesLikeMe

    Genetic Association Database (GAD): SCD5
    Human Genome Epidemiology (HuGE) Navigator: SCD5 (5 documents)

    Export disorders for SCD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCD5 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with SCD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. (PubMed id 15907797)1, 2, 9 Wang J.... Cao G. (Biochem. Biophys. Res. Commun. 2005)
    2. Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip. (PubMed id 12727354)1, 2, 9 Beiraghi S.... Sumegi J. (Gene 2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5. (PubMed id 17468887)1, 9 Lengi A.J. and Corl B.A. (Lipids 2007)
    8. Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. (PubMed id 15610069)1, 9 Zhang S....Shi Y. (Biochem. J. 2005)
    9. Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2. (PubMed id 23867797)1 Sieber J....Jehle A.W. (Am. J. Pathol. 2013)
    10. StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation. (PubMed id 22745828)1 Sinner D.I....Igal R.A. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79966 HGNC: 21088 AceView: SCD4 Ensembl:ENSG00000145284 euGenes: HUgn79966
    ECgene: SCD5 Kegg: 79966 H-InvDB: SCD5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCD5 gene:
    Search GeneIP for patents involving SCD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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