Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCD5 Gene

protein-coding   GIFtS: 55
GCID: GC04M083550

Stearoyl-CoA Desaturase 5

(Previous name: stearoyl-CoA desaturase 4)
(Previous symbol: SCD4)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Stearoyl-CoA Desaturase 51 2     Stearoyl-CoA 9-Desaturase2 3
SCD41 2 3 5     HSCD52 3
ACOD42 3 5     EC 1.14.19.13 8
Stearoyl-CoA Desaturase 41 2     FADS42
Acyl-CoA-Desaturase 42 3     SCD22

External Ids:    HGNC: 210881   Entrez Gene: 799662   Ensembl: ENSG000001452847   OMIM: 6083705   UniProtKB: Q86SK93   

Export aliases for SCD5 gene to outside databases

Previous GC identifers: GC04M083910 GC04M083770 GC04M079292


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCD5 Gene:
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that
catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of
energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been
identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human.
SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In
contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al.,
2005 (PubMed 15907797)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SCD5 Gene: 
SCD5 (stearoyl-CoA desaturase 5) is a protein-coding gene. Diseases associated with SCD5 include spondylocostal dysostosis, and dysostosis, and among its related super-pathways are Fatty acid elongation. GO annotations related to this gene include stearoyl-CoA 9-desaturase activity and iron ion binding. An important paralog of this gene is SCD.

UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9
Function: Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9
position




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCD5 gene promoter:
         Nkx3-1 v4   AML1a   NF-AT   NF-AT4   NF-AT2   FOXJ2 (long isoform)   Nkx3-1 v3   NF-AT3   FOXJ2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCD5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCD5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.22   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21.3

SCD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCD5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M083550:  view genomic region     (about GC identifiers)

Start:
83,550,690 bp from pter      End:
83,720,010 bp from pter
Size:
169,321 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9 (See protein sequence)
Recommended Name: Stearoyl-CoA desaturase 5  
Size: 330 amino acids; 37610 Da
Cofactor: Iron (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: B2RPG0 Q4W5Q5 Q8NDS0 Q9H7D1
Alternative splicing: 2 isoforms:  Q86SK9-1   Q86SK9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCD5: NX_Q86SK9

Explore proteomics data for SCD5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86SK9

  • 4/6 DME Specific Peptides for SCD5 (Q86SK9) (see all 6)
     TDADPHN  PTLVPWY  RDHRAHH  LVNSAAH 

    SCD5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCD5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001032671.2  NP_079182.2  

    ENSEMBL proteins: 
     ENSP00000316329   ENSP00000273908   ENSP00000282709  

    Human Recombinant Protein Products for SCD5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SCD5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SCD5
    GenScript Custom Purified and Recombinant Proteins Services for SCD5
    Novus Biologicals SCD5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCD5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    SCD5 for ontologies           About GeneDecksing



    SCD5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SCD5
    GenScript Custom Superior Antibodies Services for SCD5
    Novus Biologicals SCD5 Antibodies
    Search for Antibodies for SCD5 at Abcam
    Cloud-Clone Corp. Antibodies for SCD5 
    Search ThermoFisher Antibodies for SCD5
    LSBio Antibodies in human, mouse, rat for SCD5 

    Assay Products for SCD5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SCD5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCD5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCD5 
    Cloud-Clone Corp. CLIAs for SCD5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FADS: Fatty acid desaturases

    3 InterPro protein domains:
     IPR015876 Fatty_acid_desaturase-1_core
     IPR001522 Fatty_acid_desaturase-1_C
     IPR005804 Fatty_acid_desaturase-1

    Graphical View of Domain Structure for InterPro Entry Q86SK9

    ProtoNet protein and cluster: Q86SK9

    1 Blocks protein domain: IPB001522 Fatty acid desaturase

    UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9
    Domain: The histidine box domains may contain the active site and/or be involved in metal ion binding (By
    similarity)
    Similarity: Belongs to the fatty acid desaturase family


    SCD5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCD5_HUMAN, Q86SK9
    Function: Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9
    position
    Catalytic activity: Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2
    H(2)O

         Enzyme Number (IUBMB): EC 1.14.19.11 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004768stearoyl-CoA 9-desaturase activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0016717oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water ----
         
    SCD5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SCD5:
     Decreased viability of wild-ty  High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCD5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCD5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCD5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCD5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCD5
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SCD5 (see all 62):
    hsa-miR-194* hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-411 hsa-miR-548k hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidSCD5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCD5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCD5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCD5
    Sirion Biotech Customized adenovirus for overexpression of SCD5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SCD5 (see all 12)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCD5 (NM_024906)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCD5
    Sirion Biotech Customized lentivirus for stable overexpression of SCD5 
                         Customized lentivirus expression plasmids for stable overexpression of SCD5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SCD5
    Search LifeMap BioReagents cell lines for SCD5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCD5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SCD5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    oleate biosynthesis II (animals)0.32
    2PPAR signaling pathway
    PPAR signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SCD5
        oleate biosynthesis II (animals)


    2         Kegg Pathways  (Kegg details for SCD5):
        Biosynthesis of unsaturated fatty acids
    PPAR signaling pathway


    SCD5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for SCD5 (Q86SK93 ENSP000003163294) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319473I2D: score=1 
    ACOT4ENSP000003230714STRING: ENSP00000323071
    UBCENSP000003448184STRING: ENSP00000344818
    NPLOC4ENSP000003314874STRING: ENSP00000331487
    SC5DENSP000002640274STRING: ENSP00000264027
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006633fatty acid biosynthetic process IEA--

    SCD5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCD5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCD5

    5 HMDB Compounds for SCD5    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--
    Oleoyl-CoAOleoyl-Coa 1716-06-9--
    OxygenOxygen (see all 5)7782-44-7--
    Stearoyl-CoAOctadecanoyl-CoA (see all 16)362-66-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 Novoseek inferred chemical compound relationships for SCD5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ibmx 52.6 1 10946019 (1)
    histidine 33.3 1 17468887 (1)
    lipid 30.9 1 10946019 (1)
    dexamethasone 23.8 1 10946019 (1)

    Search CenterWatch for drugs/clinical trials and news about SCD5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCD5 gene (2 alternative transcripts): 
    NM_001037582.2  NM_024906.2  

    Unigene Cluster for SCD5:

    Stearoyl-CoA desaturase 5
    Hs.379191  [show with all ESTs]
    Unigene Representative Sequence: NM_001037582
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319540(uc003hna.2) ENST00000273908(uc003hnb.4) ENST00000282709(uc003hnc.3)


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCD5
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SCD5 (see all 62):
    hsa-miR-194* hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-411 hsa-miR-548k hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidSCD5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCD5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCD5
    Clone
    Products:
         
    OriGene clones in human, mouse for SCD5 (see all 12)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCD5 (NM_024906)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCD5
    Sirion Biotech Customized lentivirus for stable overexpression of SCD5 
                         Customized lentivirus expression plasmids for stable overexpression of SCD5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SCD5
    OriGene qSTAR qPCR primer pairs in human, mouse for SCD5
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCD5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCD5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCD5

    Additional mRNA sequence: 

    AF389338.1 AK024685.1 AL831891.1 BC004936.1 BC048971.1 BC137429.1 BC137432.1 

    11 DOTS entries:

    DT.317674  DT.95242421  DT.92425447  DT.99961670  DT.92425446  DT.95242401  DT.95242423  DT.100699976 
    DT.121233270  DT.91840145  DT.95242404 

    24/255 AceView cDNA sequences (see all 255):

    AI262177 Z44301 AF389338 AI124706 BQ575927 AA781761 CR621269 BC004936 
    CB241958 BU620577 H88534 CR601926 AI401562 CR621321 AI625601 BM722138 
    AI815927 AW264140 CK905449 N45466 T32057 AA293039 AV708127 AI928515 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SCD5    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                -     -           -               
    SP2:                                -     -                           
    SP3:                                                                  
    SP4:                                -     -     -     -               


    ECgene alternative splicing isoforms for SCD5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCD5 expression in normal human tissues (normalized intensities)      SCD5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAATTAAT
    SCD5 Expression
    About this image


    SCD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells
             cd4+ cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             Appendix   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Superior Cervical Ganglion   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Trigeminal Ganglion   
     
     Heart (Cardiovascular System)
             Atrioventricular Node

    See SCD5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCD5

    SOURCE GeneReport for Unigene cluster: Hs.379191

    UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9
    Tissue specificity: Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and
    pancreas, and at lower levels in kidney and lung

        SABiosciences Custom PCR Arrays for SCD5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SCD5
    OriGene qSTAR qPCR primer pairs in human, mouse for SCD5
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCD5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCD5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCD5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SCD5 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia SCD51 stearoyl-CoA desaturase 5 91.28(n)
    89.41(a)
      487831  XM_544953.3  XP_544953.2 
    chicken
    (Gallus gallus)
    Aves SCD51 stearoyl-CoA desaturase 5 75.44(n)
    79(a)
      422598  XM_420557.3  XP_420557.3 
    zebrafish
    (Danio rerio)
    Actinopterygii scd1 stearoyl-CoA desaturase (delta-9-desaturase) 68.77(n)
    70.88(a)
      386661  NM_198815.1  NP_942110.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta desat11 CG5887-PA 59.49(n)
    50.15(a)
      117369  NM_169468.1  NP_731712.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fat-61 Protein FAT-6 53.68(n)
    49.47(a)
      178122  NM_069854.6  NP_502255.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OLE11 Ole1p 45.14(n)
    34.69(a)
      852825   NP_011460.3 


    ENSEMBL Gene Tree for SCD5 (if available)
    TreeFam Gene Tree for SCD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCD5 gene
    SCD2  
    1 SIMAP similar gene for SCD5 using alignment to 3 protein entries:     SCD5_HUMAN (see all proteins):
    SCD

    SCD5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3751 SNPs in SCD5 are shown (see all 3751)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339458381,2
    C--79312705(+) TAACT-/GTATTTT 1 -- int11Minor allele frequency- GT:0.00NA 2
    rs106328131,2
    C--83415774(+) AGAAA-/GA    
       A
    /GAG
    AGAAA
    4 -- cds1 trp30--------
    rs1494074371,2
    C--83550201(+) GACACA/GTTAAG 1 -- int10--------
    rs46934711,2
    C,F,A,H--83550210(+) AGAAGT/CTTCTA 1 -- int121Minor allele frequency- C:0.40NA NS EA WA 1334
    rs1862462861,2
    --83550306(+) TAGAGG/TGAAAA 1 -- int10--------
    rs769499911,2
    C,F--83550315(+) AACAGG/AAGTCC 1 -- int13Minor allele frequency- A:0.04CSA WA NA 239
    rs1149138871,2
    F--83550392(+) GGGTGA/GCATAT 1 -- int11Minor allele frequency- G:0.01WA 118
    rs799491431,2
    C,F--83550404(+) GGAGTA/TGATTC 1 -- int11Minor allele frequency- T:0.20WA 118
    rs76705151,2
    C,F,H--83550413(+) TCCCAT/ATTATC 1 -- int199Minor allele frequency- A:0.37NS NA EA PA EU CA WA CSA 4886
    rs76758871,2
    C,F,A,H--83550606(+) CAATGC/TGAGTC 1 -- int1107Minor allele frequency- T:0.36NS NA EA PA EU CA WA CSA 6440

    HapMap Linkage Disequilibrium report for SCD5 (83550690 - 83720010 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for SCD5 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2421771CNV Deletion20811451
    esv2662825CNV Deletion23128226
    esv2656999CNV Deletion23128226
    esv29299CNV Loss19812545
    nsv292149CNV Loss16902084
    nsv517479CNV Loss19592680
    nsv291633CNV Loss16902084
    nsv829989CNV Loss17160897
    nsv818247CNV Loss17921354
    esv8610CNV Loss19470904

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SCD5
    DNA2.0 Custom Variant and Variant Library Synthesis for SCD5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608370    OMIM disorders: --

    8 diseases for SCD5:    About MalaCards
    spondylocostal dysostosis    dysostosis    obesity    human immunodeficiency virus infectious disease
    cleft lip    intrahepatic cholangiocarcinoma    cholangiocarcinoma    alzheimer's disease


    SCD5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SCD5
    Human Genome Epidemiology (HuGE) Navigator: SCD5 (5 documents)

    Export disorders for SCD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCD5 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with SCD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. (PubMed id 15907797)1, 2, 9 Wang J.... Cao G. (2005)
    2. Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip. (PubMed id 12727354)1, 2, 9 Beiraghi S.... Sumegi J. (2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5. (PubMed id 17468887)1, 9 Lengi A.J. and Corl B.A. (2007)
    8. Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. (PubMed id 15610069)1, 9 Zhang S....Shi Y. (2005)
    9. StearoylCoA desaturase-5: a novel regulator of neurona l cell proliferation and differentiation. (PubMed id 22745828)1 Sinner D.I....Igal R.A. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79966 HGNC: 21088 AceView: SCD4 Ensembl:ENSG00000145284 euGenes: HUgn79966
    ECgene: SCD5 Kegg: 79966 H-InvDB: SCD5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCD5 gene:
    Search GeneIP for patents involving SCD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SCD5  
     OriGene qPCR primer pairs and template standards for SCD5   OriGene Protein Over-expression Lysate for SCD5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SCD5  
     OriGene qSTAR qPCR primer pairs in human, mouse for SCD5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCD5   OriGene Custom Protein Services for SCD5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCD5
     QIAGEN SeqTarget long-range PCR primers for resequencing SCD5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCD5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCD5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCD5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCD5
     GenScript Custom Purified and Recombinant Proteins Services for SCD5 GenScript cDNA clones with any tag delivered in your preferred vector for SCD5
     GenScript Custom Assay Services for SCD5 GenScript Custom Superior Antibodies Services for SCD5
     GenScript Custom overexpressing Cell Line Services for SCD5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SCD5 promoter
     Search Chromatin IP Primers for SCD5
     RT2 qPCR Primer Assay in human, mouse / rat SCD5
     GNC Network for SCD5
     SABiosciences Custom PCR Arrays for SCD5
     Search Tocris compounds for SCD5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SCD5 antibodies
     SCD5 lysates
     Search for Antibodies for SCD5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SCD5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SCD5
     Antibodies for SCD5
     ELISAs for SCD5
     CLIAs for SCD5
     Search LifeMap BioReagents cell lines for SCD5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCD5
     SwitchGear 3'UTR luciferase reporter plasmids for SCD5
     SwitchGear Promoter luciferase reporter plasmids for SCD5
     Search ThermoFisher Antibodies for SCD5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCD5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SCD5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCD5
    Customized:
     lentivirus for stable overexpression of SCD5
     lentivirus expression plasmids for stable overexpression of SCD5
     adenovirus for overexpression of SCD5
     LSBio Antibodies in human, mouse, rat for SCD5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SCD5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4