Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCD5 Gene

protein-coding   GIFtS: 54
GCID: GC04M083550

stearoyl-CoA desaturase 5

(Previous name: stearoyl-CoA desaturase 4 )
(Previous symbol: SCD4)
 Explore 12 diseases affiliated with
SCD5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SCD5    

Aliases
for SCD5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Stearoyl-CoA Desaturase 51 2     Acyl-CoA-Desaturase 42 3
ACOD41 2 3 5     Stearoyl-CoA 9-Desaturase2 3
SCD41 2 3 5     EC 1.14.19.13 8
HSCD51 2 3     FLJ210321
FADS41 2     SCD22
Stearoyl-CoA Desaturase 41 2     

External Ids:    HGNC: 210881   Entrez Gene: 799662   Ensembl: ENSG000001452847   OMIM: 6083705   UniProtKB: Q86SK93   

Export aliases for SCD5 gene to outside databases

Previous GC identifers: GC04M083910 GC04M083770 GC04M079292


Summaries
for SCD5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SCD5:
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes
the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy
metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in
mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about
85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares
limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 (PubMed
15907797)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9
Function: Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position




Genomic Views
for SCD5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCD5 gene promoter:
         Nkx3-1 v4   AML1a   NF-AT   NF-AT4   NF-AT2   FOXJ2 (long isoform)   Nkx3-1 v3   NF-AT3   FOXJ2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SCD5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCD5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.22   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21.3

SCD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCD5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M083550:  view genomic region     (about GC identifiers)

Start:
 83,550,690 bp from pter      End:
 83,720,010 bp from pter
Size:
 169,321 bases      Orientation:
 minus strand

Proteins
for SCD5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9 (See protein sequence)
Recommended Name: Stearoyl-CoA desaturase 5  
Size: 330 amino acids; 37610 Da
Cofactor: Iron (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: B2RPG0 Q4W5Q5 Q8NDS0 Q9H7D1
Alternative splicing: 2 isoforms:  Q86SK9-1   Q86SK9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCD5: NX_Q86SK9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86SK9

    • 4/6 DME Specific Peptides for SCD5 (Q86SK9) (see all 6)
     TDADPHN  PTLVPWY  RDHRAHH  LVNSAAH 

    SCD5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032671.2  NP_079182.2  

    ENSEMBL proteins: 
     ENSP00000316329   ENSP00000273908   ENSP00000282709  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): SCD5
    OriGene Custom Protein Services for SCD5 
    GenScript Custom Purified and Recombinant Proteins Services for SCD5
    Novus Biologicals SCD5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SCD5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--


    SCD5 for ontologies           About GeneDecksing



    SCD5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SCD5 
    GenScript Custom Superior Antibodies Services for SCD5
    Novus Biologicals SCD5 Antibodies
    Search for Antibodies for SCD5 at Abcam  
    Uscn Antibodies for SCD5
    Search ThermoFisher Antibodies for SCD5

    Assay Products for SCD5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCD5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SCD5

    Protein Domains /
    Families
    for SCD5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SCD5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015876 Fatty_acid_desaturase-1_core
     IPR001522 Fatty_acid_desaturase-1_C
     IPR005804 Fatty_acid_desaturase-1

    Graphical View of Domain Structure for InterPro Entry Q86SK9

    ProtoNet protein and cluster: Q86SK9

    1 Blocks protein family: IPB001522 Fatty acid desaturase

    UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9
    Domain: The histidine box domains may contain the active site and/or be involved in metal ion binding (By similarity)
    Similarity: Belongs to the fatty acid desaturase family


    Function
    for SCD5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9
    Function: Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position
    Catalytic activity: Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O

    Enzyme Number (IUBMB): EC 1.14.19.11 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): SCD5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCD5
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SCD5 (see all 62):
    hsa-miR-194* hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-411 hsa-miR-548k hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmid: SCD5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCD5
    OriGene shRNA RFP: SCD5
    OriGene siRNA: SCD5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCD5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SCD5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCD5 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCD5 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SCD5 (NM_024906)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCD5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SCD5
    Search LifeMap BioReagents cell lines for SCD5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCD5

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004768stearoyl-CoA 9-desaturase activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0016717oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water ----


    SCD5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SCD5:
     Decreased viability of wild-ty  High actin ratio cells 


    Pathways & Interactions
    for SCD5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Biosynthesis of unsaturated fatty acids
    		Biosynthesis of unsaturated fatty acids1.00
    		oleate biosynthesis II (animals)0.32
    2PPAR signaling pathway
    		PPAR signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SCD5 
        oleate biosynthesis II (animals)


    2         Kegg Pathways  (Kegg details for SCD5):
        Biosynthesis of unsaturated fatty acids
    PPAR signaling pathway


    SCD5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for SCD5 (Q86SK93 ENSP000003163294) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319473I2D: score=1 
    ACOT4ENSP000003230714STRING: ENSP00000323071
    UBCENSP000003448184STRING: ENSP00000344818
    NPLOC4ENSP000003314874STRING: ENSP00000331487
    SC5DLENSP000002640274STRING: ENSP00000264027
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--


    SCD5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SCD5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCD5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCD5

    5 HMDB Compounds for SCD5    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--
    Oleoyl-CoAOleoyl-Coa 1716-06-9--
    OxygenOxygen (see all 5)7782-44-7--
    Stearoyl-CoAOctadecanoyl-CoA (see all 16)362-66-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    4 Novoseek chemical compound relationships for SCD5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ibmx 52.6 1 10946019 (1)
    histidine 33.3 1 17468887 (1)
    lipid 30.9 1 10946019 (1)
    dexamethasone 23.8 1 10946019 (1)

    Search CenterWatch for drugs/clinical trials and news about SCD5 

    Transcripts
    for SCD5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SCD5 gene (2 alternative transcripts): 
    NM_001037582.2  NM_024906.2  

    Unigene Cluster for SCD5:

    Stearoyl-CoA desaturase 5
    Hs.379191  [show with all ESTs]
    Unigene Representative Sequence: NM_001037582
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319540(uc003hna.2) ENST00000273908(uc003hnb.4) ENST00000282709(uc003hnc.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SCD5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCD5
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SCD5 (see all 62):
    hsa-miR-194* hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-411 hsa-miR-548k hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmid: SCD5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCD5
    OriGene shRNA RFP: SCD5
    OriGene siRNA: SCD5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCD5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCD5 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCD5 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SCD5 (NM_024906)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCD5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCD5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCD5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCD5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCD5

    Additional cDNA sequence: 

    AF389338.1 AK024685.1 AL831891.1 BC004936.1 BC048971.1 BC137429.1 BC137432.1 

    11 DOTS entries:

    DT.317674  DT.95242421  DT.92425447  DT.99961670  DT.92425446  DT.95242401  DT.95242423  DT.100699976 
    DT.121233270  DT.91840145  DT.95242404 

    24/255 AceView cDNA sequences (see all 255):

    AI124706 CR621269 AF389338 AW264140 CK905449 N45466 T32057 AA293039 
    BQ575927 AI262177 AV708127 Z44301 AA781761 CR621321 AI815927 BM722138 
    AI625601 AI401562 CR601926 BU620577 H88534 CB241958 BC004936 BF035547 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SCD5    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                -     -           -               
    SP2:                                -     -                           
    SP3:                                                                  
    SP4:                                -     -     -     -               


    ECgene alternative splicing isoforms for SCD5

    Expression
    for SCD5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAATTAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SCD5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCD5

    SOURCE GeneReport for Unigene cluster: Hs.379191

    UniProtKB/Swiss-Prot: SCD5_HUMAN, Q86SK9
    Tissue specificity: Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas,
    and at lower levels in kidney and lung

        SABiosciences Custom PCR Arrays for SCD5
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCD5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCD5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCD5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCD5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCD5

    Orthologs
    for SCD5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SCD5 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SCD51 stearoyl-CoA desaturase 5 75.44(n)
    79(a)    		   422598  XM_420557.3  XP_420557.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SCD6
    		 --
    		 60(a)
    		 1 ↔ 1
    		 GL343388.1(141616-151024)
    zebrafish
    (Danio rerio)    		 Actinopterygii scd1 stearoyl-CoA desaturase (delta-9-desaturase) 68.77(n)
    70.88(a)    		   386661  NM_198815.1  NP_942110.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta desat11 CG5887-PA 59.49(n)
    50.15(a)    		   117369  NM_169468.1  NP_731712.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea fat-61 Protein FAT-6 53.68(n)
    49.47(a)    		   178122  NM_069854.6  NP_502255.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes OLE11 Ole1p 45.14(n)
    34.69(a)    		   852825   NP_011460.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G061006
    AT1G063606
    (see all 9)    		 delta-9 desaturase-like 5 protein
    (see all 9)    		 24(a)
    24(a)
    (see all 9)    		 possible ortholog
    possible ortholog
    (see all 9)    		 1(1851530-1853019)
    1(1938963-1940459)


    ENSEMBL Gene Tree for SCD5 (if available)
    TreeFam Gene Tree for SCD5 (if available) 

    Paralogs
    for SCD5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCD5 gene
    SCD2  
    1 SIMAP similar gene for SCD5 using alignment to 3 protein entries:     SCD5_HUMAN (see all proteins):
    SCD

    SCD5 for paralogs           About GeneDecksing



    Genomic Variants
    for SCD5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for SCD5
         9 CNVs: 6287 92226 51470 10050 51469 6286 38572 62223 63877
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCD5
    DNA2.0 Custom Variant and Variant Library Synthesis for SCD5

    Disorders / Diseases
    for SCD5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SCD5 for disorders           About GeneDecksing

    OMIM gene information: 608370    OMIM disorders: --

    12 diseases for SCD5:    About MalaCards
    obesity    human immunodeficiency virus infectious disease    spondylocostal dysostosis    dysostosis
    cleft lip    intrahepatic cholangiocarcinoma    cholangiocarcinoma    obesity, resistance to
    alzheimer's disease    immunodeficiency    cholesterol    malaria

    Human Genome Epidemiology (HuGE) Navigator: SCD5 (5 documents)

    Export disorders for SCD5 gene to outside databases

    Publications
    for SCD5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCD5 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with SCD5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. (PubMed id 15907797)1, 2, 9 Wang J.... Cao G. (2005)
    2. Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip. (PubMed id 12727354)1, 2, 9 Beiraghi S.... Sumegi J. (2003)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5. (PubMed id 17468887)1, 9 Lengi A.J. and Corl B.A. (2007)
    5. Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. (PubMed id 15610069)1, 9 Zhang S....Shi Y. (2005)
    6. StearoylCoA desaturase-5: a novel regulator of neurona l cell proliferation and differentiation. (PubMed id 22745828)1 Sinner D.I....Igal R.A. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Elevated stearoyl-CoA desaturase in brains of patient s with Alzheimer's disease. (PubMed id 22046234)1 Astarita G....Piomelli D. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for SCD5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SCD5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79966 HGNC: 21088 AceView: SCD4 Ensembl:ENSG00000145284 euGenes: HUgn79966
    ECgene: SCD5 Kegg: 79966 H-InvDB: SCD5

    Other Databases showing SCD5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SCD5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCD5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SCD5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SCD5 gene:
    Search GeneIP for patents involving SCD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SCD5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SCD5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCD5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCD5  
     OriGene Protein Over-expression Lysate for SCD5   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SCD5   OriGene 3'-UTR Clone for SCD5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCD5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCD5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCD5   OriGene Custom Protein Services for SCD5  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCD5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCD5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCD5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCD5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCD5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCD5
     GenScript Custom Purified and Recombinant Proteins Services for SCD5 GenScript cDNA clones with any tag delivered in your preferred vector for SCD5
     GenScript Custom Assay Services for SCD5 GenScript Custom Superior Antibodies Services for SCD5
     GenScript Custom overexpressing Cell Line Services for SCD5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SCD5 promoter
     Search Chromatin IP Primers for SCD5
     RT2 qPCR Primer Assay in human, mouse / rat SCD5
     GNC Network for SCD5
     SABiosciences Custom PCR Arrays for SCD5
     Search Tocris compounds for SCD5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SCD5 antibodies
     SCD5 lysates
     Search for Antibodies for SCD5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SCD5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SCD5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SCD5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCD5
     SwitchGear 3'UTR luciferase reporter plasmids for SCD5
     SwitchGear Promoter luciferase reporter plasmids for SCD5
     Search ThermoFisher Antibodies for SCD5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCD5
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SCD5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4