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Aliases for SCD5 Gene

Aliases for SCD5 Gene

  • Stearoyl-CoA Desaturase 5 2 3
  • ACOD4 3 4 6
  • SCD4 3 4 6
  • Stearoyl-CoA Desaturase 4 2 3
  • Stearoyl-CoA 9-Desaturase 3 4
  • Acyl-CoA-Desaturase 4 3 4
  • EC 1.14.19.1 4 63
  • HSCD5 3 4
  • FADS4 3
  • SCD2 3

External Ids for SCD5 Gene

Previous Symbols for SCD5 Gene

  • SCD4

Summaries for SCD5 Gene

Entrez Gene Summary for SCD5 Gene

  • Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SCD5 Gene

SCD5 (Stearoyl-CoA Desaturase 5) is a Protein Coding gene. Diseases associated with SCD5 include spondylocostal dysostosis and obesity. Among its related pathways are PPAR signaling pathway and Fatty acid metabolism. GO annotations related to this gene include iron ion binding and stearoyl-CoA 9-desaturase activity. An important paralog of this gene is SCD.

UniProtKB/Swiss-Prot for SCD5 Gene

  • Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCD5 Gene

Genomics for SCD5 Gene

Genomic Location for SCD5 Gene

Start:
82,629,537 bp from pter
End:
82,798,857 bp from pter
Size:
169,321 bases
Orientation:
Minus strand

Genomic View for SCD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCD5 Gene

Regulatory Elements for SCD5 Gene

Proteins for SCD5 Gene

  • Protein details for SCD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SK9-SCD5_HUMAN
    Recommended name:
    Stearoyl-CoA desaturase 5
    Protein Accession:
    Q86SK9
    Secondary Accessions:
    • B2RPG0
    • Q4W5Q5
    • Q8NDS0
    • Q9H7D1

    Protein attributes for SCD5 Gene

    Size:
    330 amino acids
    Molecular mass:
    37610 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCD5 Gene

Proteomics data for SCD5 Gene at MOPED

Selected DME Specific Peptides for SCD5 Gene

Post-translational modifications for SCD5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys17 and Lys136

Other Protein References for SCD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SCD5 Gene

Gene Families for SCD5 Gene

HGNC:
  • FADS :Fatty acid desaturases

Suggested Antigen Peptide Sequences for SCD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SK9

UniProtKB/Swiss-Prot:

SCD5_HUMAN
Domain:
  • The histidine box domains may contain the active site and/or be involved in metal ion binding.:
    • Q86SK9
Family:
  • Belongs to the fatty acid desaturase family.:
    • Q86SK9
genes like me logo Genes that share domains with SCD5: view

Function for SCD5 Gene

Molecular function for SCD5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O
UniProtKB/Swiss-Prot Function: Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position.

Enzyme Numbers (IUBMB) for SCD5 Gene

Gene Ontology (GO) - Molecular Function for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004768 stearoyl-CoA 9-desaturase activity IEA --
GO:0005506 iron ion binding IEA --
genes like me logo Genes that share ontologies with SCD5: view

Phenotypes for SCD5 Gene

genes like me logo Genes that share phenotypes with SCD5: view

miRNA for SCD5 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SCD5 Gene

Localization for SCD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCD5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCD5 Gene COMPARTMENTS Subcellular localization image for SCD5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCD5: view

Pathways for SCD5 Gene

genes like me logo Genes that share pathways with SCD5: view

Pathways by source for SCD5 Gene

Interacting Proteins for SCD5 Gene

Gene Ontology (GO) - Biological Process for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SCD5: view

Compounds for SCD5 Gene

(5) HMDB Compounds for SCD5 Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6
Oleoyl-CoA
  • Oleoyl-Coa
1716-06-9
Oxygen
  • Oxygen
7782-44-7
Stearoyl-CoA
  • Octadecanoyl-CoA
362-66-3
Water
  • Dihydrogen oxide
7732-18-5

(4) Novoseek inferred chemical compound relationships for SCD5 Gene

Compound -log(P) Hits PubMed IDs
ibmx 52.6 1
histidine 33.3 1
lipid 30.9 1
dexamethasone 23.8 1
genes like me logo Genes that share compounds with SCD5: view

Transcripts for SCD5 Gene

mRNA/cDNA for SCD5 Gene

Unigene Clusters for SCD5 Gene

Stearoyl-CoA desaturase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - -
SP3:
SP4: - - - -

Relevant External Links for SCD5 Gene

GeneLoc Exon Structure for
SCD5
ECgene alternative splicing isoforms for
SCD5

Expression for SCD5 Gene

mRNA expression in normal human tissues for SCD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCD5 Gene

This gene is overexpressed in Brain - Amygdala (4.6), Brain - Spinal cord (cervical c-1) (4.3), and Brain - Substantia nigra (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCD5 Gene

SOURCE GeneReport for Unigene cluster for SCD5 Gene Hs.379191

mRNA Expression by UniProt/SwissProt for SCD5 Gene

Q86SK9-SCD5_HUMAN
Tissue specificity: Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung.
genes like me logo Genes that share expressions with SCD5: view

Orthologs for SCD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCD5 35
  • 99.49 (n)
  • 99.7 (a)
SCD5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCD5 35
  • 88.08 (n)
  • 89.09 (a)
SCD5 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCD5 35
  • 91.2 (n)
  • 89.13 (a)
SCD5 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCD5 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCD5 35
  • 81.95 (n)
  • 87.35 (a)
zebrafish
(Danio rerio)
Actinopterygii scd 35
  • 68.76 (n)
  • 70.38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001713 35
  • 60.27 (n)
  • 56.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15531 36
  • 23 (a)
ManyToMany
CG8630 36
  • 37 (a)
ManyToMany
CG9743 36
  • 35 (a)
ManyToMany
CG9747 36
  • 29 (a)
ManyToMany
desat1 35
  • 60.73 (n)
  • 53.08 (a)
desat1 36
  • 40 (a)
ManyToMany
desat2 36
  • 43 (a)
ManyToMany
Fad2 36
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fat-5 36
  • 39 (a)
ManyToMany
fat-6 36
  • 43 (a)
ManyToMany
fat-7 36
  • 42 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLE1 36
  • 18 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06100 35
  • 44.95 (n)
  • 34.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
ManyToMany
CSA.9813 36
  • 50 (a)
ManyToMany
CSA.9947 36
  • 47 (a)
ManyToMany
Species with no ortholog for SCD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCD5 Gene

ENSEMBL:
Gene Tree for SCD5 (if available)
TreeFam:
Gene Tree for SCD5 (if available)

Paralogs for SCD5 Gene

Paralogs for SCD5 Gene

Selected SIMAP similar genes for SCD5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCD5: view

Variants for SCD5 Gene

Sequence variations from dbSNP and Humsavar for SCD5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs6840 -- 82,629,854(-) TGTAG(C/T)TTCTG utr-variant-3-prime
rs16833 -- 82,698,549(-) ggaag(G/T)cactg intron-variant
rs869949 -- 82,648,416(-) CTGAG(C/G)ACCTC intron-variant
rs906151 -- 82,648,511(-) TTCTC(A/G)AGATC intron-variant
rs906152 -- 82,648,414(-) GAGCA(C/G)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCD5 Gene

Variant ID Type Subtype PubMed ID
nsv829989 CNV Loss 17160897
nsv879511 CNV Loss 21882294
esv8610 CNV Loss 19470904
esv2656999 CNV Deletion 23128226
nsv292149 CNV Loss 16902084
nsv517479 CNV Loss 19592680
esv2662825 CNV Deletion 23128226
esv29299 CNV Loss 19812545
esv2421771 CNV Deletion 20811451
nsv818247 CNV Loss 17921354
nsv441894 CNV CNV 18776908
nsv514228 CNV Loss 21397061
nsv524141 CNV Gain 19592680
nsv291633 CNV Loss 16902084

Relevant External Links for SCD5 Gene

HapMap Linkage Disequilibrium report
SCD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCD5 Gene

Disorders for SCD5 Gene

Relevant External Links for SCD5

Genetic Association Database (GAD)
SCD5
Human Genome Epidemiology (HuGE) Navigator
SCD5
genes like me logo Genes that share disorders with SCD5: view

No data available for UniProtKB/Swiss-Prot for SCD5 Gene

Publications for SCD5 Gene

  1. Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip. (PMID: 12727354) Beiraghi S. … Sumegi J. (Gene 2003) 3 4 23
  2. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. (PMID: 15907797) Wang J. … Cao G. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48

Products for SCD5 Gene

Sources for SCD5 Gene

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