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Aliases for SCD5 Gene

Aliases for SCD5 Gene

  • Stearoyl-CoA Desaturase 5 2 3 5
  • Stearoyl-CoA Desaturase 4 2 3
  • Stearoyl-CoA 9-Desaturase 3 4
  • Stearoyl-CoA Desaturase 2 3 4
  • Acyl-CoA-Desaturase 4 3 4
  • EC 1.14.19.1 4 61
  • ACOD4 3 4
  • HSCD5 3 4
  • SCD4 3 4
  • SCD2 3 4
  • FADS4 3

External Ids for SCD5 Gene

Previous HGNC Symbols for SCD5 Gene

  • SCD4

Previous GeneCards Identifiers for SCD5 Gene

  • GC04M083910
  • GC04M083770
  • GC04M083550
  • GC04M079292

Summaries for SCD5 Gene

Entrez Gene Summary for SCD5 Gene

  • Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SCD5 Gene

SCD5 (Stearoyl-CoA Desaturase 5) is a Protein Coding gene. Diseases associated with SCD5 include Obesity and Chromosome 4Q21 Deletion Syndrome. Among its related pathways are PPAR signaling pathway and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include iron ion binding and stearoyl-CoA 9-desaturase activity. An important paralog of this gene is SCD.

UniProtKB/Swiss-Prot for SCD5 Gene

  • Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:15610069). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCD5 Gene

Genomics for SCD5 Gene

Regulatory Elements for SCD5 Gene

Enhancers for SCD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SCD5 on UCSC Golden Path with GeneCards custom track

Promoters for SCD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCD5 Gene

Chromosome:
4
Start:
82,629,537 bp from pter
End:
82,798,857 bp from pter
Size:
169,321 bases
Orientation:
Minus strand

Genomic View for SCD5 Gene

Genes around SCD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCD5 Gene

Proteins for SCD5 Gene

  • Protein details for SCD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SK9-SCD5_HUMAN
    Recommended name:
    Stearoyl-CoA desaturase 5
    Protein Accession:
    Q86SK9
    Secondary Accessions:
    • B2RPG0
    • Q4W5Q5
    • Q8NDS0
    • Q9H7D1

    Protein attributes for SCD5 Gene

    Size:
    330 amino acids
    Molecular mass:
    37610 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • May self-associate and form homodimers.

    Alternative splice isoforms for SCD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCD5 Gene

Selected DME Specific Peptides for SCD5 Gene

Post-translational modifications for SCD5 Gene

  • Ubiquitination at Lys 17 and Lys 136
  • Modification sites at PhosphoSitePlus

Other Protein References for SCD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SCD5 Gene

Gene Families for SCD5 Gene

Suggested Antigen Peptide Sequences for SCD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SK9

UniProtKB/Swiss-Prot:

SCD5_HUMAN :
  • The histidine box domains are involved in binding the catalytic metal ions.
  • Belongs to the fatty acid desaturase type 1 family.
Domain:
  • The histidine box domains are involved in binding the catalytic metal ions.
Family:
  • Belongs to the fatty acid desaturase type 1 family.
genes like me logo Genes that share domains with SCD5: view

Function for SCD5 Gene

Molecular function for SCD5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:15610069). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids.

Enzyme Numbers (IUBMB) for SCD5 Gene

Gene Ontology (GO) - Molecular Function for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004768 stearoyl-CoA 9-desaturase activity IDA 15907797
GO:0016491 oxidoreductase activity IDA 15907797
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SCD5: view
genes like me logo Genes that share phenotypes with SCD5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCD5

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCD5 Gene

Localization for SCD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCD5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCD5 Gene COMPARTMENTS Subcellular localization image for SCD5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
peroxisome 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCD5: view

Pathways & Interactions for SCD5 Gene

genes like me logo Genes that share pathways with SCD5: view

Interacting Proteins for SCD5 Gene

Gene Ontology (GO) - Biological Process for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006636 unsaturated fatty acid biosynthetic process IDA 15907797
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SCD5: view

No data available for SIGNOR curated interactions for SCD5 Gene

Drugs & Compounds for SCD5 Gene

(5) Drugs for SCD5 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
MK-8245 Pharma SCD inhibitor,potent and liver-selective 0

(6) Additional Compounds for SCD5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Oleoyl-CoA
  • Octadecenoyl-CoA (n-C18:1CoA)
  • Oleoyl-Coa
1716-06-9
stearoyl-coa
  • Octadecanoyl-CoA
  • Octadecanoyl-coenzyme A
  • S-Octadecanoate
  • S-Octadecanoate CoA
  • S-Octadecanoate Coenzyme A
362-66-3

(1) ApexBio Compounds for SCD5 Gene

Compound Action Cas Number
MK-8245 SCD inhibitor,potent and liver-selective 1030612-90-8
genes like me logo Genes that share compounds with SCD5: view

Transcripts for SCD5 Gene

mRNA/cDNA for SCD5 Gene

Unigene Clusters for SCD5 Gene

Stearoyl-CoA desaturase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - -
SP3:
SP4: - - - -

Relevant External Links for SCD5 Gene

GeneLoc Exon Structure for
SCD5
ECgene alternative splicing isoforms for
SCD5

Expression for SCD5 Gene

mRNA expression in normal human tissues for SCD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCD5 Gene

This gene is overexpressed in Brain - Amygdala (x4.6), Brain - Spinal cord (cervical c-1) (x4.3), and Brain - Substantia nigra (x4.3).

Protein differential expression in normal tissues from HIPED for SCD5 Gene

This gene is overexpressed in Frontal cortex (11.7), Fetal Brain (9.7), Fetal testis (9.1), Islet of Langerhans (8.8), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCD5 Gene



Protein tissue co-expression partners for SCD5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCD5 Gene:

SCD5

SOURCE GeneReport for Unigene cluster for SCD5 Gene:

Hs.379191

mRNA Expression by UniProt/SwissProt for SCD5 Gene:

Q86SK9-SCD5_HUMAN
Tissue specificity: Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung.
genes like me logo Genes that share expression patterns with SCD5: view

Primer Products

Orthologs for SCD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCD5 34
  • 88.08 (n)
  • 89.09 (a)
SCD5 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCD5 34
  • 91.2 (n)
  • 89.13 (a)
SCD5 35
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCD5 34
  • 99.49 (n)
  • 99.7 (a)
SCD5 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCD5 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCD5 34
  • 81.95 (n)
  • 87.35 (a)
zebrafish
(Danio rerio)
Actinopterygii scd 34
  • 68.76 (n)
  • 70.38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001713 34
  • 60.27 (n)
  • 56.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta desat1 34
  • 60.73 (n)
  • 53.08 (a)
CG15531 35
  • 23 (a)
ManyToMany
CG8630 35
  • 37 (a)
ManyToMany
CG9743 35
  • 35 (a)
ManyToMany
CG9747 35
  • 29 (a)
ManyToMany
desat1 35
  • 40 (a)
ManyToMany
desat2 35
  • 43 (a)
ManyToMany
Fad2 35
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fat-5 35
  • 39 (a)
ManyToMany
fat-6 35
  • 43 (a)
ManyToMany
fat-7 35
  • 42 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLE1 35
  • 18 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06100 34
  • 44.95 (n)
  • 34.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
ManyToMany
CSA.9813 35
  • 50 (a)
ManyToMany
CSA.9947 35
  • 47 (a)
ManyToMany
Species where no ortholog for SCD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCD5 Gene

ENSEMBL:
Gene Tree for SCD5 (if available)
TreeFam:
Gene Tree for SCD5 (if available)

Paralogs for SCD5 Gene

Paralogs for SCD5 Gene

(1) SIMAP similar genes for SCD5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCD5: view

Variants for SCD5 Gene

Sequence variations from dbSNP and Humsavar for SCD5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs6840 -- 82,629,854(-) TGTAG(C/T)TTCTG utr-variant-3-prime
rs16833 -- 82,698,549(-) ggaag(G/T)cactg intron-variant
rs906151 -- 82,648,511(-) TTCTC(A/G)AGATC intron-variant
rs906152 -- 82,648,414(-) GAGCA(C/G)CTCTC intron-variant
rs906153 -- 82,647,480(-) AAAAT(C/G)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCD5 Gene

Variant ID Type Subtype PubMed ID
esv2421771 CNV deletion 20811451
esv2656999 CNV deletion 23128226
esv2662825 CNV deletion 23128226
esv2760893 CNV loss 21179565
esv2763372 CNV loss 21179565
esv29299 CNV loss 19812545
esv3337858 CNV duplication 20981092
esv3569538 CNV loss 25503493
esv3569539 CNV loss 25503493
esv3601179 CNV loss 21293372
esv3601180 CNV gain 21293372
esv3601181 CNV loss 21293372
esv3601182 CNV loss 21293372
esv8610 CNV loss 19470904
nsv1006474 CNV gain 25217958
nsv1136881 CNV deletion 24896259
nsv1146070 CNV deletion 26484159
nsv291633 CNV deletion 16902084
nsv292149 CNV deletion 16902084
nsv441894 CNV loss 18776908
nsv514228 CNV loss 21397061
nsv517479 CNV loss 19592680
nsv524141 CNV gain 19592680
nsv594744 CNV gain 21841781
nsv818247 CNV loss 17921354
nsv829989 CNV loss 17160897

Variation tolerance for SCD5 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCD5 Gene

Disorders for SCD5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SCD5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
chromosome 4q21 deletion syndrome
  • 4q21 microdeletion syndrome
chronic maxillary sinusitis
  • chronic antritis
- elite association - COSMIC cancer census association via MalaCards
Search SCD5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCD5

Genetic Association Database (GAD)
SCD5
Human Genome Epidemiology (HuGE) Navigator
SCD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCD5
genes like me logo Genes that share disorders with SCD5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCD5 Gene

Publications for SCD5 Gene

  1. Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. (PMID: 15610069) Zhang S. … Shi Y. (Biochem. J. 2005) 3 4 22 65
  2. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. (PMID: 15907797) Wang J. … Cao G. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 65
  3. Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip. (PMID: 12727354) Beiraghi S. … Sumegi J. (Gene 2003) 3 4 22 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65

Products for SCD5 Gene

Sources for SCD5 Gene

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