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Aliases for SCD5 Gene

Aliases for SCD5 Gene

  • Stearoyl-CoA Desaturase 5 2 3
  • ACOD4 3 4 6
  • SCD4 3 4 6
  • Stearoyl-CoA Desaturase 4 2 3
  • Stearoyl-CoA 9-Desaturase 3 4
  • Acyl-CoA-Desaturase 4 3 4
  • EC 4 63
  • HSCD5 3 4
  • FADS4 3
  • SCD2 3

External Ids for SCD5 Gene

Previous HGNC Symbols for SCD5 Gene

  • SCD4

Previous GeneCards Identifiers for SCD5 Gene

  • GC04M083910
  • GC04M083770
  • GC04M083550
  • GC04M079292

Summaries for SCD5 Gene

Entrez Gene Summary for SCD5 Gene

  • Stearoyl-CoA desaturase (SCD; EC is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SCD5 Gene

SCD5 (Stearoyl-CoA Desaturase 5) is a Protein Coding gene. Diseases associated with SCD5 include spondylocostal dysostosis and obesity. Among its related pathways are PPAR signaling pathway and Fatty acid metabolism. GO annotations related to this gene include iron ion binding and stearoyl-CoA 9-desaturase activity. An important paralog of this gene is SCD.

UniProtKB/Swiss-Prot for SCD5 Gene

  • Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCD5 Gene

Genomics for SCD5 Gene

Regulatory Elements for SCD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCD5 Gene

82,629,537 bp from pter
82,798,857 bp from pter
169,321 bases
Minus strand

Genomic View for SCD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCD5 Gene

Proteins for SCD5 Gene

  • Protein details for SCD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Stearoyl-CoA desaturase 5
    Protein Accession:
    Secondary Accessions:
    • B2RPG0
    • Q4W5Q5
    • Q8NDS0
    • Q9H7D1

    Protein attributes for SCD5 Gene

    330 amino acids
    Molecular mass:
    37610 Da
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCD5 Gene


neXtProt entry for SCD5 Gene

Proteomics data for SCD5 Gene at MOPED

Selected DME Specific Peptides for SCD5 Gene

Post-translational modifications for SCD5 Gene

  • Ubiquitination at Lys17 and Lys136
  • Modification sites at PhosphoSitePlus

Other Protein References for SCD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SCD5 Gene

Gene Families for SCD5 Gene

  • FADS :Fatty acid desaturases

Suggested Antigen Peptide Sequences for SCD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86SK9
  • The histidine box domains may contain the active site and/or be involved in metal ion binding.
  • Belongs to the fatty acid desaturase family.
genes like me logo Genes that share domains with SCD5: view

Function for SCD5 Gene

Molecular function for SCD5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O
UniProtKB/Swiss-Prot Function:
Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position.

Enzyme Numbers (IUBMB) for SCD5 Gene

Gene Ontology (GO) - Molecular Function for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004768 stearoyl-CoA 9-desaturase activity IEA --
GO:0005506 iron ion binding IEA --
genes like me logo Genes that share ontologies with SCD5: view

Phenotypes for SCD5 Gene

genes like me logo Genes that share phenotypes with SCD5: view

Animal Model Products

CRISPR Products

miRNA for SCD5 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCD5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SCD5 Gene

Localization for SCD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCD5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SCD5 Gene COMPARTMENTS Subcellular localization image for SCD5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCD5: view

Pathways for SCD5 Gene

genes like me logo Genes that share pathways with SCD5: view

Pathways by source for SCD5 Gene

Interacting Proteins for SCD5 Gene

Gene Ontology (GO) - Biological Process for SCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SCD5: view

Compounds for SCD5 Gene

(1) ApexBio Compounds for SCD5 Gene

Compound Action Cas Number
MK-8245 "SCD inhibitor,potent and liver-selective" [1030612-90-8]

(5) HMDB Compounds for SCD5 Gene

Compound Synonyms Cas Number PubMed IDs
  • Armco iron
  • Oleoyl-Coa
  • Oxygen
  • Octadecanoyl-CoA
  • Dihydrogen oxide

(4) Novoseek inferred chemical compound relationships for SCD5 Gene

Compound -log(P) Hits PubMed IDs
ibmx 52.6 1
histidine 33.3 1
lipid 30.9 1
dexamethasone 23.8 1
genes like me logo Genes that share compounds with SCD5: view

Transcripts for SCD5 Gene

mRNA/cDNA for SCD5 Gene

Unigene Clusters for SCD5 Gene

Stearoyl-CoA desaturase 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCD5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - -
SP4: - - - -

Relevant External Links for SCD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCD5 Gene

mRNA expression in normal human tissues for SCD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCD5 Gene

This gene is overexpressed in Brain - Amygdala (4.6), Brain - Spinal cord (cervical c-1) (4.3), and Brain - Substantia nigra (4.3).

Protein differential expression in normal tissues for SCD5 Gene

This gene is overexpressed in Frontal cortex (11.7), Fetal Brain (9.7), Fetal testis (9.1), Islet of Langerhans (8.8), and Testis (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCD5 Gene

SOURCE GeneReport for Unigene cluster for SCD5 Gene Hs.379191

mRNA Expression by UniProt/SwissProt for SCD5 Gene

Tissue specificity: Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung.
genes like me logo Genes that share expressions with SCD5: view

Expression partners for SCD5 Gene

In Situ Assay Products

Orthologs for SCD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCD5 35
  • 88.08 (n)
  • 89.09 (a)
SCD5 36
  • 87 (a)
(Canis familiaris)
Mammalia SCD5 35
  • 91.2 (n)
  • 89.13 (a)
SCD5 36
  • 86 (a)
(Pan troglodytes)
Mammalia SCD5 35
  • 99.49 (n)
  • 99.7 (a)
SCD5 36
  • 100 (a)
(Monodelphis domestica)
Mammalia SCD5 36
  • 76 (a)
(Gallus gallus)
Aves SCD5 35
  • 81.95 (n)
  • 87.35 (a)
(Danio rerio)
Actinopterygii scd 35
  • 68.76 (n)
  • 70.38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001713 35
  • 60.27 (n)
  • 56.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta desat1 35
  • 60.73 (n)
  • 53.08 (a)
CG15531 36
  • 23 (a)
CG8630 36
  • 37 (a)
CG9743 36
  • 35 (a)
CG9747 36
  • 29 (a)
desat1 36
  • 40 (a)
desat2 36
  • 43 (a)
Fad2 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea fat-5 36
  • 39 (a)
fat-6 36
  • 43 (a)
fat-7 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLE1 36
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06100 35
  • 44.95 (n)
  • 34.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
CSA.9813 36
  • 50 (a)
CSA.9947 36
  • 47 (a)
Species with no ortholog for SCD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCD5 Gene

Gene Tree for SCD5 (if available)
Gene Tree for SCD5 (if available)

Paralogs for SCD5 Gene

Paralogs for SCD5 Gene

Selected SIMAP similar genes for SCD5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCD5: view

Variants for SCD5 Gene

Sequence variations from dbSNP and Humsavar for SCD5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs6840 -- 82,629,854(-) TGTAG(C/T)TTCTG utr-variant-3-prime
rs16833 -- 82,698,549(-) ggaag(G/T)cactg intron-variant
rs869949 -- 82,648,416(-) CTGAG(C/G)ACCTC intron-variant
rs906151 -- 82,648,511(-) TTCTC(A/G)AGATC intron-variant
rs906152 -- 82,648,414(-) GAGCA(C/G)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCD5 Gene

Variant ID Type Subtype PubMed ID
nsv829989 CNV Loss 17160897
nsv879511 CNV Loss 21882294
esv8610 CNV Loss 19470904
esv2656999 CNV Deletion 23128226
nsv292149 CNV Loss 16902084
nsv517479 CNV Loss 19592680
esv2662825 CNV Deletion 23128226
esv29299 CNV Loss 19812545
esv2421771 CNV Deletion 20811451
nsv818247 CNV Loss 17921354
nsv441894 CNV CNV 18776908
nsv514228 CNV Loss 21397061
nsv524141 CNV Gain 19592680
nsv291633 CNV Loss 16902084

Relevant External Links for SCD5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCD5 Gene

Disorders for SCD5 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SCD5 Gene in MalaCards »

(2) Diseases for SCD5 Gene including...

Relevant External Links for SCD5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SCD5: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SCD5 Gene

Publications for SCD5 Gene

  1. Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip. (PMID: 12727354) Beiraghi S. … Sumegi J. (Gene 2003) 3 4 23
  2. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. (PMID: 15907797) Wang J. … Cao G. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48

Products for SCD5 Gene

Sources for SCD5 Gene

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