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SCD Gene

protein-coding   GIFtS: 68
GCID: GC10P102096

Stearoyl-CoA Desaturase (Delta-9-Desaturase)

(Previous name: stearoyl-CoA desaturase opposite strand)
(Previous symbol: SCDOS)
  See SCD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stearoyl-CoA Desaturase (Delta-9-Desaturase)1 2     FADS52
Fatty Acid Desaturase1 2 3     MSTP0082
SCDOS1 2     SCD12
Stearoyl-CoA Desaturase Opposite Strand1 2     delta(9)-desaturase2
Acyl-CoA Desaturase1 2     Predicted Protein Of HQ09982
delta-9-desaturase1 2     Delta(9)-desaturase3
Delta-9 Desaturase2 3     Stearoyl-CoA Desaturase3
EC 1.14.19.13 8     

External Ids:    HGNC: 105711   Entrez Gene: 63192   Ensembl: ENSG000000991947   OMIM: 6040315   UniProtKB: O007673   

Export aliases for SCD gene to outside databases

Previous GC identifers: GC10P101000 GC10P101340 GC10P102238 GC10P101771 GC10P095735


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCD Gene:
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid.
Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been
detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on
chromosome 17. (provided by RefSeq, Feb 2012)

GeneCards Summary for SCD Gene:
SCD (stearoyl-CoA desaturase (delta-9-desaturase)) is a protein-coding gene. Diseases associated with SCD include systemic primary carnitine deficiency disease, and obesity. GO annotations related to this gene include stearoyl-CoA 9-desaturase activity and iron ion binding. An important paralog of this gene is SCD5.

UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767
Function: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and
electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA
substrates including palmitoyl-CoA and stearoyl-CoA

Gene Wiki entry for SCD (Stearoyl-CoA desaturase-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCD gene promoter:
         COUP-TF1   NRSF form 1   COUP   HNF-4alpha2   NRSF form 2   HNF-4alpha1   SRY   PPAR-gamma1   COUP-TF   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): SCD promoter sequence
   Search Chromatin IP Primers for SCD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q23-q24

SCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCD gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102096:  view genomic region     (about GC identifiers)

Start:
102,106,772 bp from pter      End:
102,124,591 bp from pter
Size:
17,820 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767 (See protein sequence)
Recommended Name: Acyl-CoA desaturase  
Size: 359 amino acids; 41523 Da
Cofactor: Iron
Secondary accessions: B2R5U0 D3DR68 Q16150 Q53GR9 Q5W037 Q5W038 Q6GSS4 Q96KF6 Q9BS07 Q9Y695

Explore the universe of human proteins at neXtProt for SCD: NX_O00767

Explore proteomics data for SCD at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys162, Lys196, Lys209, Lys341
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SCD (O00767) (see all 10)
     PTLVPWY  RDHRAHH  LVNSAAH  TWLVNSA 


    See SCD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005054.3  
    ENSEMBL proteins: 
     ENSP00000359380  

    SCD Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SCD
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SCD
    GenScript Custom Purified and Recombinant Proteins Services for SCD
    Novus Biologicals SCD Protein
    Novus Biologicals SCD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCD

     
    Search eBioscience for Proteins for SCD 

    SCD Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SCD (SCD-1)
    Cell Signaling Technology (CST) Antibodies for SCD 
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    Novus Biologicals SCD Antibodies
    Abcam antibodies for SCD
    Cloud-Clone Corp. Antibodies for SCD
    ThermoFisher Antibodies for SCD
    LSBio Antibodies in human, mouse, rat for SCD

    SCD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SCD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCD
    Cloud-Clone Corp. CLIAs for SCD
    Search eBioscience for ELISAs for SCD 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FADS: Fatty acid desaturases

    3 InterPro protein domains:
     IPR015876 Fatty_acid_desaturase-1_core
     IPR001522 Fatty_acid_desaturase-1_C
     IPR005804 Fatty_acid_desaturase-1

    Graphical View of Domain Structure for InterPro Entry O00767

    ProtoNet protein and cluster: O00767

    1 Blocks protein domain: IPB001522 Fatty acid desaturase

    UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767
    Domain: The histidine box domains may contain the active site and/or be involved in metal ion binding
    Similarity: Belongs to the fatty acid desaturase family


    Find genes that share domains with SCD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACOD_HUMAN, O00767
    Function: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and
    electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA
    substrates including palmitoyl-CoA and stearoyl-CoA
    Catalytic activity: Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2
    H(2)O

         Genatlas biochemistry entry for SCD:
    stearol-CoA-desaturase

         Enzyme Number (IUBMB): EC 1.14.19.11 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004768stearoyl-CoA 9-desaturase activity IEA--
    GO:0005506iron ion binding IEA--
         
    Find genes that share ontologies with SCD           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SCD:
     Decreased G3BP1 protein expres 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Scd2):
     growth/size/body  homeostasis/metabolism  integument  limbs/digits/tail  liver/biliary system 
     mortality/aging 

    Find genes that share phenotypes with SCD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Scd2tm1Myz for SCD

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCD

    miRNA
    Products:
        
    miRTarBase miRNAs that target SCD:
    hsa-let-7e-5p (MIRT051566), hsa-mir-192-5p (MIRT026303), hsa-mir-92a-3p (MIRT049568), hsa-let-7b-5p (MIRT032312), hsa-mir-197-3p (MIRT048106), hsa-mir-335-5p (MIRT017330), hsa-mir-149-5p (MIRT045494), hsa-mir-324-5p (MIRT043242), hsa-mir-484 (MIRT041961), hsa-mir-10a-5p (MIRT047622), hsa-mir-215-5p (MIRT024946), hsa-mir-331-3p (MIRT043431), hsa-mir-155-5p (MIRT020585), hsa-mir-181a-5p (MIRT025105), hsa-mir-30a-5p (MIRT028413), hsa-mir-328-3p (MIRT043748), hsa-mir-185-5p (MIRT045367), hsa-mir-455-3p (MIRT037841), hsa-mir-1229-3p (MIRT036376)

    Block miRNA regulation of human, mouse, rat SCD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCD (see all 97):
    hsa-miR-194* hsa-miR-607 hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-199a-3p hsa-miR-605 hsa-miR-1260b hsa-miR-938
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SCD
    Predesigned siRNA for gene silencing in human, mouse, rat SCD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCD

    Clone
    Products:
         
    OriGene clones in human, mouse for SCD (see all 7)
    OriGene ORF clones in mouse, rat for SCD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCD (NM_005063)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCD

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SCD
    Browse ESI BIO Cell Lines and PureStem Progenitors for SCD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACOD_HUMAN, O00767: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    peroxisome3
    cytosol2
    extracellular2
    nucleus2
    plasma membrane2
    chloroplast1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SCD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SCD About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    oleate biosynthesis II (animals)0.32
    2Fatty acid metabolism
    Fatty acid metabolism0.42
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    SREBP signalling0.31
    4SREBF and miR33 in cholesterol and lipid homeostasis
    SREBF and miR33 in cholesterol and lipid homeostasis
    5PPAR signaling pathway
    PPAR signaling pathway


    Find genes that share SuperPaths with SCD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SCD
        Glucose / Energy Metabolism

    5 BioSystems Pathways for SCD
        Adipogenesis
    SREBP signalling
    SREBF and miR33 in cholesterol and lipid homeostasis
    oleate biosynthesis II (animals)
    Fatty Acid Biosynthesis


    3 Kegg Pathways  (Kegg details for SCD):
        Biosynthesis of unsaturated fatty acids
    Fatty acid metabolism
    PPAR signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SCD (see all 8): 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat
              Insulin Resistance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SCD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SCD (O007673 ENSP000003593804) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACSL4O604883, ENSP000003397874I2D: score=1 STRING: ENSP00000339787
    CAP2P401233, ENSP000002299224I2D: score=1 STRING: ENSP00000229922
    ENSG00000258947Q135093I2D: score=1 
    MOGAT2Q3SYC23, ENSP000001988014I2D: score=1 STRING: ENSP00000198801
    MRPL2Q5T6533, ENSP000003734044I2D: score=1 STRING: ENSP00000373404
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006633fatty acid biosynthetic process IEA--

    Find genes that share ontologies with SCD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCD (ACOD)

    Selected HMDB Compounds for SCD (see all 36)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    Selected Novoseek inferred chemical compound relationships for SCD gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stearoyl-coa 93 26 11352637 (3), 8914942 (2), 17363919 (2), 18989145 (2) (see all 16)
    sterculic acid 90.1 9 12504086 (4), 15910739 (1), 1320912 (1)
    fatty acid 85.5 235 18599738 (4), 18982375 (4), 18687433 (3), 18062827 (3) (see all 99)
    palmitoleate 84.4 12 14654089 (1), 18599738 (1), 11396956 (1), 11414710 (1) (see all 7)
    linoleic acid 76.6 34 11396956 (3), 17426927 (2), 16186393 (1), 15834635 (1) (see all 19)
    oleic acid 76.2 29 2340302 (1), 14654089 (1), 18599738 (1), 19056549 (1) (see all 22)
    stearic acid 74.9 9 14967823 (2), 18599738 (1), 10521790 (1), 14967817 (1) (see all 7)
    palmitoleic acid 71.7 9 18068341 (4), 18687433 (1), 18066610 (1)
    sterol 71.4 18 15460168 (1), 18982375 (1), 11414710 (1), 18181169 (1) (see all 15)
    acetyl-coa 67.2 15 19710915 (2), 11323427 (1), 17449569 (1), 19932008 (1) (see all 10)



    Find genes that share compounds with SCD           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCD gene: 
    NM_005063.4  

    Unigene Cluster for SCD:

    Stearoyl-CoA desaturase (delta-9-desaturase)
    Hs.558396  [show with all ESTs]
    Unigene Representative Sequence: NM_005063
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370355(uc001kqy.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCD (see all 97):
    hsa-miR-194* hsa-miR-607 hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-199a-3p hsa-miR-605 hsa-miR-1260b hsa-miR-938
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SCD
    Predesigned siRNA for gene silencing in human, mouse, rat SCD
    Clone
    Products:
         
    OriGene clones in human, mouse for SCD (see all 7)
    OriGene ORF clones in mouse, rat for SCD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCD (NM_005063)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCD
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SCD
    OriGene qSTAR qPCR primer pairs in human, mouse for SCD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCD
      QuantiTect SYBR Green Assays in human, mouse, rat SCD
      QuantiFast Probe-based Assays in human, mouse, rat SCD

    Additional mRNA sequence: 

    AB032261.1 AB208982.1 AF097514.1 AF109362.1 AF113690.1 AK222862.1 AK312312.1 BC005807.2 
    BC062303.1 S70284.1 Y13647.1 

    Selected DOTS entries (see all 59):

    DT.97863820  DT.91809273  DT.95377395  DT.95376842  DT.95377467  DT.91775766  DT.97804439  DT.95377727 
    DT.454377  DT.95377527  DT.95134979  DT.95376748  DT.100746510  DT.100746528  DT.121296789  DT.100746388 
    DT.100874096  DT.100746342  DT.100746470  DT.100746492  DT.100746509  DT.121296820  DT.121296835  DT.91775761 

    Selected AceView cDNA sequences (see all 1725):

    BE732721 BU616075 CR612541 BM551997 BM833535 AA548733 AU130094 AL598787 
    BU152678 BM801704 BQ004872 BQ691721 T34242 BF198121 BU615560 CD365782 
    BQ001631 CD365584 AA357347 AA953951 AA566087 BX494282 BU538750 CB270467 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SCD    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:              -                                 
    SP2:                                                


    ECgene alternative splicing isoforms for SCD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SCD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTGATAC
    SCD Expression
    About this image


    SCD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
    SCD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558396
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SCD (see all 8): 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat
              Insulin Resistance in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SCD gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scd25
    Scd11
    stearoyl-Coenzyme A desaturase 25
    stearoyl-Coenzyme A desaturase 11
    82.91(n)1
    85.07(a)1
      19 (37.98 cM)5
    202491  NM_009127.41  NP_033153.21 
     442936765 
    chicken
    (Gallus gallus)
    Aves SCD1 stearoyl-CoA desaturase (delta-9-desaturase) 70.52(n)
    68.17(a)
      395706  NM_204890.1  NP_990221.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCD6
    stearoyl-CoA desaturase (delta-9-desaturase)
    60(a)
    1 ↔ 1
    GL343388.1(136231-151024)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.86602 Xenopus laevis transcribed sequence with weak similarity more 70.81(n)    CB591503.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scd2 stearoyl-CoA desaturase (delta-9-desaturase) 73.52(n)   386661  AY217090.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta desat13
    desat21
    fatty acid biosynthesis stearoyl-CoA
    desaturase3
    desat21
    58(a)
    (best of 7)3
    56.69(n)1
    52.69(a)1
      87B113
    415361  NM_141944.21  NP_650201.11 
    worm
    (Caenorhabditis elegans)
    Secernentea fat-63 acyl-CoA desaturase 53(a)
    (best of 3)
      IV(11913716-11914891)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OLE1(YGL055W)4 Delta(9) fatty acid desaturase, required for monounsaturated more   --   7(398628-400160) 852825  NP_011460.1 


    ENSEMBL Gene Tree for SCD (if available)
    TreeFam Gene Tree for SCD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCD gene
    SCD52  
    1 SIMAP similar gene for SCD using alignment to 1 protein entry:     ACOD_HUMAN:
    SCD5

    Find genes that share paralogs with SCD           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SCD
    PGOHUM00000237298 PGOHUM00000235526


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCD (see all 644)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824605431,2
    --102104829(+) TTTTGC/TTGTCA 1 -- us2k10--------
    rs1481871421,2
    --102104848(+) GTAACC/TATTGT 1 -- us2k10--------
    rs2005771741,2
    --102104882(+) AGACC-/AAAAAA 1 -- us2k10--------
    rs1151356581,2
    F--102104929(+) GACCAC/TTGTCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs6868841,2
    C--102105015(-) ggccCG/AGAGAA 1 -- us2k13Minor allele frequency- A:0.09NA EA 124
    rs1890740111,2
    --102105082(+) TCACCC/TGAGGT 1 -- us2k10--------
    rs1930207161,2
    --102105109(+) GCCTGA/GCCAAC 1 -- us2k10--------
    rs1411670651,2
    C--102105133(+) GTCTCC/TACTAA 1 -- us2k10--------
    rs1473563861,2
    --102105168(+) GGTGGC/TGCATG 1 -- us2k10--------
    rs1409933011,2
    C--102105173(+) CGCATG/TCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCD (102106772 - 102124591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SCD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831961CNV Loss17160897
    nsv527448CNV Gain19592680
    nsv519672CNV Gain19592680

    Human Gene Mutation Database (HGMD): SCD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCD
    DNA2.0 Custom Variant and Variant Library Synthesis for SCD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604031    OMIM disorders: --

    2 diseases for SCD:    
    About MalaCards
    systemic primary carnitine deficiency disease    obesity

    2 diseases from the University of Copenhagen DISEASES database for SCD:
    Fatty liver disease     Diabetes mellitus

    Find genes that share disorders with SCD           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SCD gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty liver 59.3 11 12538076 (1), 19691439 (1), 18952834 (1), 20022128 (1) (see all 9)
    obesity 57.8 35 18427563 (4), 17636091 (3), 17391062 (2), 19712485 (2) (see all 20)
    insulin resistance 52.5 17 18030445 (2), 18427563 (2), 20022128 (2), 19712485 (2) (see all 11)
    metabolic disorder 46.3 5 20137926 (1), 18068341 (1), 19632834 (1), 20205608 (1)
    insulin sensitivity 42.3 14 17636091 (4), 15855323 (2), 19478146 (2), 18286258 (1) (see all 6)
    hyperlipidemia 18.7 2 12538076 (1), 12401889 (1)
    prostatic adenocarcinoma 9.38 1 15609334 (1)
    cardiovascular diseases 8.25 1 20205608 (1)
    neoplastic transformation 7 2 15851470 (1), 15708362 (1)
    inflammation 6.88 9 18687433 (2), 17614770 (1), 20216310 (1), 18062827 (1) (see all 5)

    Genetic Association Database (GAD): SCD
    Human Genome Epidemiology (HuGE) Navigator: SCD (207 documents)

    Export disorders for SCD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCD gene, integrated from 10 sources (see all 311):
    (articles sorted by number of sources associating them with SCD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. (PubMed id 10229681)1, 2, 3, 9 Zhang L.... Prouty S.M. (Biochem. J. 1999)
    2. Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues. (PubMed id 7909540)1, 2, 3 Li J.... Gilmour R.S. (Int. J. Cancer 1994)
    3. Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. (PubMed id 15662557)1, 4, 9 Liew C.F....McCarthy M.I. (Diabetologia 2004)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. (PubMed id 11415448)1, 2 Zhang L.... Prouty S.M. (Biochem. J. 2001)
    10. Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma. (PubMed id 15855323)1, 9 RisAcrus U....Karpe F. (Diabetes 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6319 HGNC: 10571 AceView: SCD Ensembl:ENSG00000099194 euGenes: HUgn6319
    ECgene: SCD Kegg: 6319 H-InvDB: SCD

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCD gene:
    Search GeneIP for patents involving SCD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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