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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCD Gene

protein-coding   GIFtS: 63
GCID: GC10P102096

stearoyl-CoA desaturase (delta-9-desaturase)

(Previous name: stearoyl-CoA desaturase opposite strand )
(Previous symbol: SCDOS)
 Explore 38 diseases affiliated with
SCD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SCD    

Aliases
for SCD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Stearoyl-CoA Desaturase (Delta-9-Desaturase)1 2     SCD12
FADS51 2     Acyl-CoA Desaturase2
SCDOS1 2     Delta(9)-Desaturase1
Stearoyl-CoA Desaturase Opposite Strand1 2     Delta-9-Desaturase1
Delta-9 Desaturase2 3     Predicted Protein Of HQ09982
Fatty Acid Desaturase2 3     Delta(9)-Desaturase1
EC 1.14.19.13 8     Stearoyl-CoA Desaturase3
MSTP0082     

External Ids:    HGNC: 105711   Entrez Gene: 63192   Ensembl: ENSG000000991947   OMIM: 6040315   UniProtKB: O007673   

Export aliases for SCD gene to outside databases

Previous GC identifers: GC10P101000 GC10P101340 GC10P102238 GC10P101771 GC10P095735


Summaries
for SCD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SCD:
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. Transcripts of
approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene
encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17.
(provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767
Function: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons
from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates
including palmitoyl-CoA and stearoyl-CoA

Gene Wiki entry for SCD (Stearoyl-CoA desaturase-1)


Genomic Views
for SCD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCD gene promoter:
         COUP-TF1   NRSF form 1   COUP   HNF-4alpha2   NRSF form 2   HNF-4alpha1   SRY   PPAR-gamma1   COUP-TF   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): SCD promoter sequence
   Search SABiosciences Chromatin IP Primers for SCD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q23-q24

SCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCD gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102096:  view genomic region     (about GC identifiers)

Start:
 102,106,772 bp from pter      End:
 102,124,591 bp from pter
Size:
 17,820 bases      Orientation:
 plus strand

Proteins
for SCD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767 (See protein sequence)
Recommended Name: Acyl-CoA desaturase  
Size: 359 amino acids; 41523 Da
Cofactor: Iron
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)
Secondary accessions: B2R5U0 D3DR68 Q16150 Q53GR9 Q5W037 Q5W038 Q6GSS4 Q96KF6 Q9BS07 Q9Y695

Explore the universe of human proteins at neXtProt for SCD: NX_O00767

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00767

    • 4/10 DME Specific Peptides for SCD (O00767) (see all 10)
     PTLVPWY  RDHRAHH  LVNSAAH  TWLVNSA 

    SCD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005054.3  
    ENSEMBL proteins: 
     ENSP00000409887   ENSP00000359380  

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    Novus Biologicals SCD Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SCD

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--


    SCD for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SCD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SCD for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015876 Fatty_acid_desaturase-1_core
     IPR001522 Fatty_acid_desaturase-1_C
     IPR005804 Fatty_acid_desaturase-1

    Graphical View of Domain Structure for InterPro Entry O00767

    ProtoNet protein and cluster: O00767

    1 Blocks protein family: IPB001522 Fatty acid desaturase

    UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767
    Domain: The histidine box domains may contain the active site and/or be involved in metal ion binding
    Similarity: Belongs to the fatty acid desaturase family


    Function
    for SCD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767
    Function: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons
    from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates
    including palmitoyl-CoA and stearoyl-CoA
    Catalytic activity: Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O

         Genatlas biochemistry entry for SCD:
    stearol-CoA-desaturase

    Enzyme Number (IUBMB): EC 1.14.19.11 2

    miRNA
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    hsa-miR-194* hsa-miR-607 hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-199a-3p hsa-miR-605 hsa-miR-1260b hsa-miR-938
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004768stearoyl-CoA 9-desaturase activity IEA--
    GO:0005506iron ion binding IEA--


    SCD for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SCD:
     Decreased G3BP1 protein expres 

    Animal Models:
         Mouse knock-out Scd2tm1Myz for SCD
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Scd2):
     growth/size  homeostasis/metabolism  integument  limbs/digits/tail  liver/biliary system 
     mortality/aging 

    SCD for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SCD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Biosynthesis of unsaturated fatty acids
    		Biosynthesis of unsaturated fatty acids1.00
    		oleate biosynthesis II (animals)0.32
    2Fatty Acid Biosynthesis
    		Fatty Acid Biosynthesis1.00
    3Adipogenesis
    		Adipogenesis1.00
    4PPAR signaling pathway
    		PPAR signaling pathway1.00
    5Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SCD
        Glucose / Energy Metabolism

    4 BioSystems Pathways for SCD 
        SREBP signalling
    Adipogenesis
    oleate biosynthesis II (animals)
    Fatty Acid Biosynthesis


    2         Kegg Pathways  (Kegg details for SCD):
        Biosynthesis of unsaturated fatty acids
    PPAR signaling pathway


    SCD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/75 Interacting proteins for SCD (O007673 ENSP000003593804) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACSL4O604883, ENSP000003397874I2D: score=1 STRING: ENSP00000339787
    ENSG00000258947Q135093I2D: score=1 
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    TUBB3Q135093I2D: score=1 
    UBCP0CG483, ENSP000003448184I2D: score=3 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--


    SCD for ontologies           About GeneDecksing



    Drugs & Compounds
    for SCD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCD

    10/36 HMDB Compounds for SCD (see all 36)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--
    10/48 Novoseek chemical compound relationships for SCD gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stearoyl-coa 93 26 11352637 (3), 8914942 (2), 17363919 (2), 18989145 (2) (see all 16)
    sterculic acid 90.1 9 12504086 (4), 15910739 (1), 1320912 (1)
    fatty acid 85.5 235 18599738 (4), 18982375 (4), 18687433 (3), 18062827 (3) (see all 99)
    palmitoleate 84.4 12 14654089 (1), 18599738 (1), 11396956 (1), 11414710 (1) (see all 7)
    linoleic acid 76.6 34 11396956 (3), 17426927 (2), 16186393 (1), 15834635 (1) (see all 19)
    oleic acid 76.2 29 2340302 (1), 14654089 (1), 18599738 (1), 19056549 (1) (see all 22)
    stearic acid 74.9 9 14967823 (2), 18599738 (1), 10521790 (1), 14967817 (1) (see all 7)
    palmitoleic acid 71.7 9 18068341 (4), 18687433 (1), 18066610 (1)
    sterol 71.4 18 15460168 (1), 18982375 (1), 11414710 (1), 18181169 (1) (see all 15)
    acetyl-coa 67.2 15 19710915 (2), 11323427 (1), 17449569 (1), 19932008 (1) (see all 10)

    Search CenterWatch for drugs/clinical trials and news about SCD / ACOD 

    Transcripts
    for SCD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SCD gene: 
    NM_005063.4  

    Unigene Cluster for SCD:

    Stearoyl-CoA desaturase (delta-9-desaturase)
    Hs.558396  [show with all ESTs]
    Unigene Representative Sequence: NM_005063
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423840 ENST00000370355(uc001kqy.3)

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    hsa-miR-194* hsa-miR-607 hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-199a-3p hsa-miR-605 hsa-miR-1260b hsa-miR-938
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    Additional cDNA sequence: 

    AB032261.1 AB208982.1 AF097514.1 AF109362.1 AF113690.1 AK222862.1 AK312312.1 BC005807.2 
    BC062303.1 S70284.1 Y13647.1 

    24/60 DOTS entries (see all 60):

    DT.97863820  DT.91809273  DT.95377395  DT.95376842  DT.91775766  DT.95377467  DT.97804439  DT.95377727 
    DT.454377  DT.95377527  DT.95134979  DT.95376748  DT.100746528  DT.121296789  DT.100746510  DT.100746388 
    DT.100874096  DT.100746470  DT.100746509  DT.121296820  DT.121296835  DT.100033311  DT.100746342  DT.100746492 

    24/1725 AceView cDNA sequences (see all 1725):

    BG119243 BU155302 BM743435 BX955244 AI092058 BU168708 BU174440 R08386 
    BU157298 BU844803 BF224292 BE645931 BU858079 BU858263 BM917310 BM560448 
    BG055160 BU931699 AL598692 BU858191 CA426644 BE271396 AA122193 T34242 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SCD    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:              -                                 
    SP2:                                                


    ECgene alternative splicing isoforms for SCD

    Expression
    for SCD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACTTGATAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SCD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCD

    SOURCE GeneReport for Unigene cluster: Hs.558396
        SABiosciences Expression via Pathway-Focused PCR Arrays including SCD (see all 8): 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat
              Insulin Resistance in human mouse rat

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    In Situ
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    Orthologs
    for SCD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SCD gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Scd25
    Scd11    		 stearoyl-Coenzyme A desaturase 25
    stearoyl-Coenzyme A desaturase 11    		 83.05(n)1
    85.31(a)1    		   19 (37.98 cM)5
    202491  NM_009127.41  NP_033153.21 
     442936765 
    chicken
    (Gallus gallus)    		 Aves SCD1 stearoyl-CoA desaturase (delta-9-desaturase) 70.52(n)
    68.17(a)    		   395706  NM_204890.1  NP_990221.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.86602 Xenopus laevis transcribed sequence with weak similarity more 70.81(n)    CB591503.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii scd2 stearoyl-CoA desaturase (delta-9-desaturase) 73.52(n)   386661  AY217090.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta desat13
    CG86301    		 fatty acid biosynthesis stearoyl-CoA
    desaturase3
    CG86301    		 58(a)
    (best of 7)3
    56(n)1
    50.51(a)1    		   87B113
    416291  NM_169500.11  NP_731781.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea fat-63 acyl-CoA desaturase 53(a)
    (best of 3)    		   IV(11913716-11914891)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G063606
    AT1G063506
    (see all 9)    		 delta-9 desaturase-like 4 protein
    (see all 9)    		 26(a)
    25(a)
    (see all 9)    		 possible ortholog
    possible ortholog
    (see all 9)    		 1(1938963-1940459)
    1(1935293-1936819)


    ENSEMBL Gene Tree for SCD (if available)
    TreeFam Gene Tree for SCD (if available) 

    Paralogs
    for SCD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCD gene
    SCD52  
    1 SIMAP similar gene for SCD using alignment to 1 protein entry:     ACOD_HUMAN:
    SCD5

    SCD for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SCD
    PGOHUM00000237298 PGOHUM00000235526


    Genomic Variants
    for SCD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/586 NCBI SNPs in SCD are shown (see all 586)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1824605431,2
    		--102104829(+) TTTTGC/TTGTCA 1 -- us2k10--------
    rs1481871421,2
    		--102104848(+) GTAACC/TATTGT 1 -- us2k10--------
    rs2005771741,2
    		--102104882(+) AGACC-/AAAAAA 1 -- us2k10--------
    rs1151356581,2
    		F,--102104929(+) GACCAC/TTGTCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs6868841,2
    		C,--102105015(-) GGCCCG/AGAGAA 1 -- us2k13Minor allele frequency- A:0.09NA EA 124
    rs1890740111,2
    		--102105082(+) TCACCC/TGAGGT 1 -- us2k10--------
    rs1930207161,2
    		--102105109(+) GCCTGA/GCCAAC 1 -- us2k10--------
    rs1411670651,2
    		--102105133(+) GTCTCC/TACTAA 1 -- us2k10--------
    rs1473563861,2
    		--102105168(+) GGTGGC/TGCATG 1 -- us2k10--------
    rs1409933011,2
    		--102105173(+) CGCATG/TCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCD (102106772 - 102124591 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SCD: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCD
    DNA2.0 Custom Variant and Variant Library Synthesis for SCD

    Disorders / Diseases
    for SCD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SCD for disorders           About GeneDecksing

    OMIM gene information: 604031    OMIM disorders: --

    20/38 diseases for SCD (see all 38):    About MalaCards
    familial combined hyperlipidemia    type 2 diabetes mellitus    insulin resistance    metabolic disorders
    fatty liver disease    hyperlipidemia    diabetes mellitus    morbid obesity
    hypertriglyceridemia    leukemia/lymphoma    skin disease    liver disease
    cystic fibrosis    adrenoleukodystrophy    prostate adenocarcinoma    obesity
    adenocarcinoma    obesity, resistance to    lung adenocarcinoma    atherosclerosis

    2 diseases from the University of Copenhagen DISEASES database for SCD:
    Fatty liver disease     Diabetes mellitus

    10/17 Novoseek disease relationships for SCD gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty liver 59.3 11 12538076 (1), 19691439 (1), 18952834 (1), 20022128 (1) (see all 9)
    obesity 57.8 35 18427563 (4), 17636091 (3), 17391062 (2), 19712485 (2) (see all 20)
    insulin resistance 52.5 17 18030445 (2), 18427563 (2), 20022128 (2), 19712485 (2) (see all 11)
    metabolic disorder 46.3 5 20137926 (1), 18068341 (1), 19632834 (1), 20205608 (1)
    insulin sensitivity 42.3 14 17636091 (4), 15855323 (2), 19478146 (2), 18286258 (1) (see all 6)
    hyperlipidemia 18.7 2 12538076 (1), 12401889 (1)
    prostatic adenocarcinoma 9.38 1 15609334 (1)
    cardiovascular diseases 8.25 1 20205608 (1)
    neoplastic transformation 7 2 15851470 (1), 15708362 (1)
    inflammation 6.88 9 18687433 (2), 17614770 (1), 20216310 (1), 18062827 (1) (see all 5)

    Genetic Association Database (GAD): SCD
    Human Genome Epidemiology (HuGE) Navigator: SCD (207 documents)

    Export disorders for SCD gene to outside databases

    Publications
    for SCD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCD gene, integrated from 9 sources (see all 296):
    (articles sorted by number of sources associating them with SCD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. (PubMed id 10229681)1, 2, 3, 9 Zhang L....Prouty S.M. (1999)
    2. Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues. (PubMed id 7909540)1, 2, 3 Li J.... Gilmour R.S. (1994)
    3. Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. (PubMed id 15662557)1, 4, 9 Liew C.F....McCarthy M.I. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. (PubMed id 11415448)1, 2 Zhang L.... Prouty S.M. (2001)
    7. Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma. (PubMed id 15855323)1, 9 Riserus U....Karpe F. (2005)
    8. Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid. (PubMed id 11397803)1, 9 Samuel W....Wiggert B. (2001)
    9. Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase. (PubMed id 16723740)1, 9 Kato H....Mihara K. (2006)
    10. Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance. (PubMed id 18030445)1, 9 Sjogren P....Fisher R.M. (2008)

    External Searches for SCD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SCD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6319 HGNC: 10571 AceView: SCD Ensembl:ENSG00000099194 euGenes: HUgn6319
    ECgene: SCD Kegg: 6319 H-InvDB: SCD

    Other Databases showing SCD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SCD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SCD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SCD gene:
    Search GeneIP for patents involving SCD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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