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Aliases for SCD Gene

Aliases for SCD Gene

  • Stearoyl-CoA Desaturase (Delta-9-Desaturase) 2 3 5
  • Fatty Acid Desaturase 2 3 4
  • Stearoyl-CoA Desaturase Opposite Strand 2 3
  • Delta(9)-Desaturase 3 4
  • Delta-9-Desaturase 2 3
  • Delta-9 Desaturase 3 4
  • EC 1.14.19.1 4 63
  • HSCD1 3 4
  • Predicted Protein Of HQ0998 3
  • Stearoyl-CoA Desaturase 4
  • Acyl-CoA Desaturase 2
  • MSTP008 3
  • FADS5 3
  • SCDOS 3
  • SCD1 3

External Ids for SCD Gene

Previous HGNC Symbols for SCD Gene

  • SCDOS

Previous GeneCards Identifiers for SCD Gene

  • GC10P101000
  • GC10P101340
  • GC10P102238
  • GC10P101771
  • GC10P102096
  • GC10P095735

Summaries for SCD Gene

Entrez Gene Summary for SCD Gene

  • This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]

GeneCards Summary for SCD Gene

SCD (Stearoyl-CoA Desaturase (Delta-9-Desaturase)) is a Protein Coding gene. Diseases associated with SCD include carnitine deficiency, systemic primary and reye syndrome. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include iron ion binding and stearoyl-CoA 9-desaturase activity. An important paralog of this gene is SCD5.

UniProtKB/Swiss-Prot for SCD Gene

  • Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).

Gene Wiki entry for SCD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCD Gene

Genomics for SCD Gene

Regulatory Elements for SCD Gene

Promoters for SCD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCD on UCSC Golden Path with GeneCards custom track

Genomic Location for SCD Gene

Chromosome:
10
Start:
100,347,015 bp from pter
End:
100,364,834 bp from pter
Size:
17,820 bases
Orientation:
Plus strand

Genomic View for SCD Gene

Genes around SCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCD Gene

Proteins for SCD Gene

  • Protein details for SCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00767-ACOD_HUMAN
    Recommended name:
    Acyl-CoA desaturase
    Protein Accession:
    O00767
    Secondary Accessions:
    • B2R5U0
    • D3DR68
    • Q16150
    • Q53GR9
    • Q5W037
    • Q5W038
    • Q6GSS4
    • Q96KF6
    • Q9BS07
    • Q9Y695

    Protein attributes for SCD Gene

    Size:
    359 amino acids
    Molecular mass:
    41523 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • May self-associate and form homodimers.

    Three dimensional structures from OCA and Proteopedia for SCD Gene

neXtProt entry for SCD Gene

Proteomics data for SCD Gene at MOPED

Post-translational modifications for SCD Gene

  • Ubiquitination at Lys 162, Lys 196, Lys 209, and Lys 341
  • Modification sites at PhosphoSitePlus

Other Protein References for SCD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SCD (SCD)

Domains & Families for SCD Gene

Gene Families for SCD Gene

Protein Domains for SCD Gene

Suggested Antigen Peptide Sequences for SCD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00767

UniProtKB/Swiss-Prot:

ACOD_HUMAN :
  • The histidine box domains are involved in binding the catalytic metal ions.
  • Belongs to the fatty acid desaturase type 1 family.
Domain:
  • The histidine box domains are involved in binding the catalytic metal ions.
Family:
  • Belongs to the fatty acid desaturase type 1 family.
genes like me logo Genes that share domains with SCD: view

Function for SCD Gene

Molecular function for SCD Gene

GENATLAS Biochemistry:
stearol-CoA-desaturase
UniProtKB/Swiss-Prot CatalyticActivity:
Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).

Enzyme Numbers (IUBMB) for SCD Gene

genes like me logo Genes that share phenotypes with SCD: view

Animal Models for SCD Gene

MGI Knock Outs for SCD:

Animal Model Products

  • Taconic Biosciences Mouse Models for SCD

CRISPR Products

miRNA for SCD Gene

miRTarBase miRNAs that target SCD

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCD Gene

Localization for SCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCD Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCD Gene COMPARTMENTS Subcellular localization image for SCD gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
peroxisome 3
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 2
chloroplast 1
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IDA 18765284
genes like me logo Genes that share ontologies with SCD: view

Pathways & Interactions for SCD Gene

genes like me logo Genes that share pathways with SCD: view

SIGNOR curated interactions for SCD Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for SCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006636 unsaturated fatty acid biosynthetic process IDA 15907797
GO:0044255 cellular lipid metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SCD: view

Drugs & Compounds for SCD Gene

(58) Drugs for SCD Gene - From: ClinicalTrials, Novoseek, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alemtuzumab Approved, Investigational Pharma Therapeutic Antibodies 302
Bosentan Approved, Investigational Pharma 100
Busulfan Approved, Investigational Pharma 506
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2643
Epoetin alfa Approved Pharma 626

(62) Additional Compounds for SCD Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
stearoyl-coa
  • Octadecanoyl-CoA
  • Octadecanoyl-coenzyme A
  • S-Octadecanoate
  • S-Octadecanoate CoA
  • S-Octadecanoate Coenzyme A
362-66-3
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
genes like me logo Genes that share compounds with SCD: view

Transcripts for SCD Gene

mRNA/cDNA for SCD Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1725) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCD Gene

Stearoyl-CoA desaturase (delta-9-desaturase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for SCD Gene

GeneLoc Exon Structure for
SCD
ECgene alternative splicing isoforms for
SCD

Expression for SCD Gene

mRNA expression in normal human tissues for SCD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCD Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.2), Adipose - Visceral (Omentum) (x6.0), and Adipose - Subcutaneous (x4.9).

Protein differential expression in normal tissues from HIPED for SCD Gene

This gene is overexpressed in Fetal testis (11.1), Bone (10.3), Lung (10.0), Fetal Liver (8.0), Adrenal (7.5), and Spinal cord (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCD Gene



SOURCE GeneReport for Unigene cluster for SCD Gene Hs.558396

mRNA Expression by UniProt/SwissProt for SCD Gene

O00767-ACOD_HUMAN
Tissue specificity: Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
genes like me logo Genes that share expression patterns with SCD: view

In Situ Assay Products

No data available for Protein tissue co-expression partners for SCD Gene

Orthologs for SCD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCD 35
  • 99.44 (n)
  • 98.89 (a)
SCD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 84 (a)
OneToMany
SCD 36
  • 86 (a)
OneToMany
SCD 35
  • 86.07 (n)
  • 86.07 (a)
dog
(Canis familiaris)
Mammalia SCD 35
  • 89.42 (n)
  • 90.25 (a)
SCD 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scd1 36
  • 85 (a)
OneToMany
Scd2 36
  • 83 (a)
OneToMany
Scd3 36
  • 83 (a)
OneToMany
Scd4 36
  • 78 (a)
OneToMany
Scd1 16
Scd1 35
  • 82.91 (n)
  • 85.07 (a)
oppossum
(Monodelphis domestica)
Mammalia SCD 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCD 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scd1 35
  • 83.61 (n)
  • 85.2 (a)
chicken
(Gallus gallus)
Aves SCD 36
  • 66 (a)
OneToOne
SCD 35
  • 70.52 (n)
  • 68.17 (a)
lizard
(Anolis carolinensis)
Reptilia SCD 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8660 35
tropical clawed frog
(Silurana tropicalis)
Amphibia scd 35
  • 64.69 (n)
  • 64.49 (a)
zebrafish
(Danio rerio)
Actinopterygii scd 36
  • 61 (a)
OneToMany
scdb 36
  • 62 (a)
OneToMany
scd 35
scdb 35
  • 64.18 (n)
  • 63.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15531 36
  • 27 (a)
ManyToMany
CG8630 36
  • 37 (a)
ManyToMany
CG9743 36
  • 37 (a)
ManyToMany
CG9747 36
  • 32 (a)
ManyToMany
desat1 36
  • 47 (a)
ManyToMany
desat2 36
  • 47 (a)
ManyToMany
Fad2 36
  • 43 (a)
ManyToMany
CG15531 37
  • 29 (a)
CG8630 37
  • 50 (a)
CG9743 37
  • 53 (a)
CG9747 37
  • 49 (a)
desat1 37
  • 58 (a)
desat2 37
  • 52 (a)
Fad2 37
  • 50 (a)
desat2 35
  • 56.69 (n)
  • 52.69 (a)
worm
(Caenorhabditis elegans)
Secernentea fat-5 37
  • 46 (a)
fat-6 37
  • 53 (a)
fat-7 37
  • 53 (a)
fat-5 36
  • 41 (a)
ManyToMany
fat-6 36
  • 46 (a)
ManyToMany
fat-7 36
  • 46 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLE1 36
  • 22 (a)
OneToMany
OLE1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
CSA.9813 36
  • 46 (a)
ManyToMany
CSA.9947 36
  • 47 (a)
ManyToMany
Species with no ortholog for SCD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCD Gene

ENSEMBL:
Gene Tree for SCD (if available)
TreeFam:
Gene Tree for SCD (if available)

Paralogs for SCD Gene

Paralogs for SCD Gene

(1) SIMAP similar genes for SCD Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SCD Gene

genes like me logo Genes that share paralogs with SCD: view

Variants for SCD Gene

Sequence variations from dbSNP and Humsavar for SCD Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs641996 -- 100,359,189(-) AACAG(A/G)TCAGA intron-variant
rs1054412 -- 100,360,850(+) GTCTG(A/G)CCTAT reference, missense
rs1056901 -- 100,363,747(+) GAACA(C/T)GATTT utr-variant-3-prime
rs2027450 -- 100,363,883(+) CTTTT(C/T)TAATC utr-variant-3-prime
rs2234970 - 100,356,554(+) TGCTG(A/C)TGATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SCD Gene

Variant ID Type Subtype PubMed ID
nsv831961 CNV Loss 17160897
nsv519672 CNV Gain 19592680
nsv527448 CNV Gain 19592680

Variation tolerance for SCD Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCD Gene

HapMap Linkage Disequilibrium report
SCD
Human Gene Mutation Database (HGMD)
SCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCD Gene

Disorders for SCD Gene

MalaCards: The human disease database

(5) MalaCards diseases for SCD Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
carnitine deficiency, systemic primary
  • systemic primary carnitine deficiency disease
reye syndrome
  • reye's syndrome
obesity
  • obesity, association with
overnutrition
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association - COSMIC cancer census association via MalaCards
Search SCD in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCD

Genetic Association Database (GAD)
SCD
Human Genome Epidemiology (HuGE) Navigator
SCD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCD
genes like me logo Genes that share disorders with SCD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCD Gene

Publications for SCD Gene

  1. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. (PMID: 10229681) Zhang L. … Prouty S.M. (Biochem. J. 1999) 2 3 4 23 67
  2. De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury. (PMID: 20032470) Collins J.M. … Frayn K.N. (J. Biol. Chem. 2010) 3 23
  3. Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. (PMID: 18952834) Kotronen A. … Yki-JAorvinen H. (Diabetes 2009) 3 23
  4. Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. (PMID: 19478146) Peter A. … Schleicher E. (Diabetes 2009) 3 23
  5. Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. (PMID: 19710915) Scaglia N. … Igal R.A. (PLoS ONE 2009) 3 23

Products for SCD Gene

Sources for SCD Gene

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