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SCD Gene

protein-coding GIFtS: 66

GC10P102096

stearoyl-CoA desaturase (delta-9-desaturase)
(Previous name: stearoyl-CoA desaturase opposite strand )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SCDOS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Delta(9)-desaturase ^³
EC 1.14.19.1 ^³
FADS5 ^¹, ²
MSTP008 ^²
OTTHUMP00000020279 ^²
SCD1 ^²
SCDOS ^²
delta-9-desaturase ^²

Descriptions
Fatty acid desaturase ^², ³
Stearoyl-CoA desaturase ^³
acyl-CoA desaturase ^²
predicted protein of HQ0998 ^²
stearoyl-CoA desaturase (delta-9-desaturase) ^²
stearoyl-CoA desaturase 1 ^²
stearoyl-CoA desaturase opposite strand ^¹, ²

External Ids
HGNC: 10571¹
Entrez Gene: 6319²
UniProtKB: O00767³
Ensembl: ENSG00000099194⁷

Search outside databases for aliases for SCD gene

Previous GC identifers: GC10P101000 GC10P101340 GC10P102238 GC10P101771

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SCD:

Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an iron-containing enzyme that catalyzes a

rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is

oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic

acid has been implicated in the regulation of cell growth and differentiation through effects on

cell membrane fluidity and signal transduction. Four SCD isoforms, Scd1 through Scd4, have been

identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5 (MIM 608370), have been

identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as

well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and

appears to be unique to primates (Zhang et al. (1999) [PubMed 10229681]; Wang et al., 2005 [PubMed

15907797]).[supplied by OMIM]

UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767

Function: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes

O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a

spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SCD gene

Entrez Gene cytogenetic band: 10q24.31 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q23-q24

SCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P102096: (about GC identifiers)

Start:	102,096,762 bp from pter
End:	102,114,578 bp from pter
Size:	17,817 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767 (See protein sequence)

Recommended Name: Acyl-CoA desaturase

Size: 359 amino acids; 41523 Da

Cofactor: Iron

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)

Secondary accessions: B2R5U0 Q16150 Q53GR9 Q5W037 Q5W038 Q6GSS4 Q96KF6 Q9BS07 Q9Y695

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005054.3

ENSEMBL proteins:

ENSP00000359380

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SCD)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for SCD:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SCD
	R&D Systems Antibodies for SCD (SCD-1)
	Cell Signaling Technology (CST) Antibodies for SCD (SCD1)
	Antibodies from Abcam (SCD), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SCD)
	Novus Biologicals Antibody for SCD

Assays for SCD:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O00767

ProtoNet protein and cluster: O00767

1 Blocks protein family: IPB001522 Fatty acid desaturase

UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767

Domain: The histidine box domains may contain the active site and/or be involved in metal ion

binding

Similarity: Belongs to the fatty acid desaturase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SCD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SCD)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005063

Applied Biosystems Silencer® siRNAs for SCD

Sigma-Aldrich siRNA and siRNA Panels for SCD

Sigma-Aldrich shRNA for SCD

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SCD
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005063
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005063
untagged cDNA clone in CMV expression vector: NM_005063

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005063

UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767

Function: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes

O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a

spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA

Catalytic activity: Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2

ferricytochrome b5 + 2 H(2)O

Enzyme Number (IUBMB): EC 1.14.19.1

Genatlas biochemistry entry for SCD:

stearol-CoA-desaturase

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Scd2):

growth/size	homeostasis/metabolism	lethality-prenatal/perinatal	limbs/digits/tail	liver/biliary system
skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004768	stearoyl-CoA 9-desaturase activity	TAS	10229681
GO:0005506	iron ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for SCD (Your Favorite Gene powered by Ingenuity)

LXR/RXR Activation
PXR/RXR Activation

GeneDecks SCD for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for SCD

5/28 Interacting proteins for SCD (ENSP00000359380³) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SREBF1	ENSP00000348069³	STRING (score=.969)
INS	ENSP00000370731³	STRING (score=.967)
FADS1	ENSP00000322229³	STRING (score=.957)
FADS2	ENSP00000278840³	STRING (score=.957)
PPARG	ENSP00000287820³	STRING (score=.955)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006633	fatty acid biosynthetic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SCD
10/33 Novoseek chemical compound relationships for SCD gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
stearoyl-coa	93.75	26	11352637 (3), 8914942 (2), 17363919 (2), 18989145 (2) (see all 16)
sterculic acid	86.25	9	12504086 (4), 15910739 (1), 1320912 (1)
palmitoleate	86.04	12	14654089 (1), 18599738 (1), 11396956 (1), 11414710 (1) (see all 7)
fatty acid	84.78	196	18599738 (4), 18982375 (4), 18687433 (3), 18062827 (3) (see all 99)
oleic acid	78.10	29	2340302 (1), 14654089 (1), 18599738 (1), 19056549 (1) (see all 22)
linoleic acid	75.89	32	11396956 (3), 17426927 (2), 16186393 (1), 16571147 (1) (see all 17)
palmitoleic acid	73.74	9	18068341 (4), 18687433 (1), 18066610 (1)
sterol	70.04	14	15460168 (1), 18982375 (1), 11414710 (1), 18181169 (1) (see all 12)
acetyl-coa	64.55	10	11323427 (1), 17449569 (1), 12463690 (1), 18239551 (1) (see all 8)
lipid	63.11	38	17485339 (4), 16213227 (2), 17391062 (2), 19119140 (2) (see all 24)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SCD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SCD)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005063

Sigma-Aldrich siRNA and siRNA Panels for SCD

Sigma-Aldrich shRNA for SCD

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005063

REFSEQ mRNAs for SCD gene:

NM_005063.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005063

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005063
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005063
                                 untagged cDNA clone in CMV expression vector: NM_005063

Additional cDNA sequence:

AB032261.1 AB208982.1 AF097514.1 AF109362.1 AF113690.1 AK222862.1 AK312312.1 BC005807.2

BC062303.1 S70284.1 Y13647.1

24/57 DOTS entries (see all 57 ):

DT.97863820 DT.91809273 DT.95377395 DT.95376842 DT.95377467 DT.91775766 DT.97804439 DT.95377727

DT.454377 DT.95377527 DT.95376748 DT.95134979 DT.121296789 DT.100746528 DT.100746510 DT.100746388

DT.100874096 DT.100746470 DT.121296820 DT.100746342 DT.121296835 DT.40124097 DT.91775761 DT.100746492

24/1725 AceView cDNA sequences (see all 1725 ):

BQ689271 BU686418 BM557930 BQ029193 AA857999 BU633457 BU622758 BQ919918

BQ899280 AI632229 AW630775 BU191505 BG028756 CD677252 T33743 BU844803

BQ879564 AI873858 CB529241 BQ923468 CD654151 AI096555 CB270038 AI554586

highest scoring ESTs for SCD:

Y13647 AA148484 AA972173 AF097514 AI018246 AI065157 AI220058 AI635560 AL120451 AL562021

Unigene Cluster for SCD:

Stearoyl-CoA desaturase (delta-9-desaturase)

Hs.558396 [show with all ESTs]

Unigene Representative Sequence: NM_005063

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SCD

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6
SP1:					-
SP2:

About this scheme

ECgene alternative splicing isoforms for SCD

1 Ensembl transcript including schematic representation:

ENST00000370355

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SCD expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SCD

¹ / ² / ³

10 probe-sets matching SCD gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37513_at²^{, 3}	U95-A	4	0.69	0.49	0.95	1.08	Y13647	1.00	1.00	1.00	1
31773_at²^{, 3}	U95-A	2	0.31	0.56	0.92	0.94	U06715	0.20	0.50	0.38	1
200832_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB032261	0.60	1.00	0.82	1
200831_s_at²^{, 3}	U133-A	3	1.00	0.71	--	--	AA678241	0.60	1.00	0.82	1
211162_x_at²^{, 3}	U133-A	3	1.00	0.53	--	--	AF116616	0.20	1.00	0.72	1
211708_s_at²^{, 3}	U133-A	3	1.00	0.44	--	--	BC005807	0.80	1.00	0.91	1
200832_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200831_s_at²	U133Plus2	3	1.00	0.71	--	--	--	--	--	--	--
211162_x_at²	U133Plus2	3	1.00	0.53	--	--	--	--	--	--	--
211708_s_at²	U133Plus2	3	1.00	0.44	--	--	--	--	--	--	--

GeneDecks SCD for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATGACCTATT

SOURCE GeneReport for Unigene cluster: Hs.558396
Expression variation in blood from EXPOLDB for SCD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SCD gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SCD¹	--	stearoyl-CoA desaturase (delta-9-desaturase)	89.42(n) 90.25(a)	486839 XM_543968.2 XP_543968.2
chimpanzee (Pan troglodytes)	SCD¹	--	stearoyl-CoA desaturase (delta-9-desaturase)	99.44(n) 98.89(a)	450676 XM_001168563.1 XP_001168563.1
rat (Rattus norvegicus)	Scd1¹	--	stearoyl-Coenzyme A desaturase 1	83.47(n) 85.15(a)	246074 NM_139192.1 NP_631931.1
mouse (Mus musculus)	Scd2⁵ Scd1¹	19 (43.00 cM)⁵	stearoyl-Coenzyme A desaturase 2⁵ stearoyl-Coenzyme A desaturase 1¹	83.05(n)¹ 85.31(a)¹	20249¹ NM_009127.3¹ NP_033153.2¹ AK078543⁵ AK083085⁵ (see all 16)
chicken (Gallus gallus)	SCD¹	--	stearoyl-CoA desaturase (delta-9-desaturase)	70.52(n) 68.17(a)	395706 NM_204890.1 NP_990221.1

About this table Species with no ortholog for SCD

ENSEMBL Gene Tree for SCD

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SCD gene

SCD5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/135 NCBI SNPs in SCD are shown (see all 135 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 61)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs508384^1,2	A,C,F,H,O	102114751(+)	`TGGGAC/AGCAGG`	1	--	ng3¹		7	NA EU EA WA	509
	rs670213^1,2	A,C,F,H	102096357(+)	`CCGAGC/TCCCCC`	1	--	ng5¹		5	MN EU EA WA	584
--	rs560792^1,2	A,C,F,H	102113033(+)	`TCAAAG/CCAGAA`	1	--	ut3¹ ese³		16	MN NA EU EA WA	1576
	rs2234970^1,2	A,C,F,H	102106301(+)	`TGCTGA/CTGATG`	1	M/L	mis¹		9	EU EA WA NA	697
--	rs3978768^1,2	A,C,F,H	102111569(+)	`CCAGAA/GTTGGT`	1	--	ut3¹		12	EU EA WA NA	1047
	rs10883465^1,2	A,C,F,H	102112177(+)	`GTATAC/GAACTG`	1	--	ut3¹ ese³		13	NA MN EU EA WA	1234
--	rs7849^1,2	A,C,F,H	102112593(-)	`TCAACA/GTGAGC`	1	--	ut3¹ ese³		9	MN EU EA WA NA	926
--	rs11557927^1,2	C,F,H	102111806(+)	`AGTATT/GTCCCT`	1	--	ut3¹ trp³		7	NA EU EA WA	554
	rs1054411^1,2	C,F,O	102097241(+)	`GCATCC/GGAGAG`	1	--	ut5¹ ese³		4	EA NA	1430
	rs2275656^1,2	A,C,F	102096195(+)	`CGCGGG/CCTTGG`	1	--	ng5¹		2	EA MN	906

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HapMap Linkage Disequilibrium images for SCD (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604031

10/16 Novoseek disease relationships for SCD gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
obesity	48.68	25	18427563 (4), 17636091 (3), 17391062 (2), 16477801 (2) (see all 13)
fatty liver	48.52	6	12538076 (1), 18952834 (1), 19258494 (1), 15333742 (1) (see all 5)
insulin resistance	39.72	10	18030445 (2), 18427563 (2), 18062827 (2), 10521790 (1) (see all 7)
insulin sensitivity	35.33	11	17636091 (4), 15855323 (2), 18286258 (1), 15662557 (1)
metabolic disorder	32.48	1	18068341 (1)
prostatic adenocarcinoma	12.66	1	15609334 (1)
neoplastic transformation	10.27	2	15851470 (1), 15708362 (1)
hyperlipidemia	5.60	2	12538076 (1), 12401889 (1)
tumors	1.35	3	18813799 (1), 17483353 (1)
hypertriglyceridemia	1.27	1	12401889 (1)

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Genetic Association Database: SCD
Human Genome Epidemiology Navigator: SCD (139 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/221 PubMed articles for SCD gene (see all 221 ):

Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. (PubMed id 10229681)^{1, 2, 3, 4} Zhang L....Prouty S.M. (1999)
Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues. (PubMed id 7909540)^{2, 3, 4} Li J.... Gilmour R.S. (1994)
Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. (PubMed id 15662557)^{1, 3, 6} Liew C.F....McCarthy M.I. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. (PubMed id 11415448)^{3, 4} Zhang L.... Prouty S.M. (2001)
Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma. (PubMed id 15855323)^{1, 3} Riserus U....Karpe F. (2005)
Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid. (PubMed id 11397803)^{1, 3} Samuel W....Wiggert B. (2001)
Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase. (PubMed id 16723740)^{1, 3} Kato H....Mihara K. (2006)
Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance. (PubMed id 18030445)^{1, 3} Sjogren P....Fisher R.M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6319	HGNC: 10571	AceView: SCD	Ensembl:ENSG00000099194	euGenes: HUgn6319
ECgene: SCD	H-InvDB: SCD

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for SCD
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SCD:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

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Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SCD-related products

	Millipore Custom Antibody & Bulk Services
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	Millipore Target Screening & Profiling Services

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Antibodies & Assays for SCD (SCD1)

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Antibodies for SCD

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SCD Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for SCD

Summaries
for SCD

Genomic Location
for SCD

Proteins
for SCD

Protein Domains/
Families
for SCD

Gene Function
for SCD

Pathways & Interactions
for SCD

Drugs & Compounds
for SCD

Transcripts
for SCD

Expression
for SCD

Orthologs
for SCD

Paralogs
for SCD

SNPs/Variants
for SCD

Disorders & Mutations
for SCD

Medical News
for SCD

Publications
for SCD

Search for SCD

Genome Databases showing SCD

Other Databases showing SCD

Specialized Databases showing SCD

Licensable Technologies
for SCD

Services
for SCD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SCD Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor SCD

Summariesfor SCD

Genomic Locationfor SCD

Proteinsfor SCD

Protein Domains/Familiesfor SCD

Gene Functionfor SCD

Pathways & Interactionsfor SCD

Drugs & Compoundsfor SCD

Transcriptsfor SCD

Expression for SCD

Orthologsfor SCD

Paralogsfor SCD

SNPs/Variantsfor SCD

Disorders & Mutationsfor SCD

Medical Newsfor SCD

Publicationsfor SCD

Search for SCD

Genome Databases showing SCD

Other Databases showing SCD

Specialized Databases showing SCD

Licensable Technologiesfor SCD

Servicesfor SCD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SCD

Summaries
for SCD

Genomic Location
for SCD

Proteins
for SCD

Protein Domains/
Families
for SCD

Gene Function
for SCD

Pathways & Interactions
for SCD

Drugs & Compounds
for SCD

Transcripts
for SCD

Expression
for SCD

Orthologs
for SCD

Paralogs
for SCD

SNPs/Variants
for SCD

Disorders & Mutations
for SCD

Medical News
for SCD

Publications
for SCD

Licensable Technologies
for SCD

Services
for SCD