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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCD Gene

protein-coding   GIFtS: 67
GCID: GC10P102096

Stearoyl-CoA Desaturase (Delta-9-Desaturase)

(Previous name: stearoyl-CoA desaturase opposite strand)
(Previous symbol: SCDOS)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Stearoyl-CoA Desaturase (Delta-9-Desaturase)1 2     FADS52
Fatty Acid Desaturase1 2 3     MSTP0082
SCDOS1 2     SCD12
Stearoyl-CoA Desaturase Opposite Strand1 2     delta(9)-desaturase2
Acyl-CoA Desaturase1 2     Predicted Protein Of HQ09982
delta-9-desaturase1 2     Delta(9)-desaturase3
Delta-9 Desaturase2 3     Stearoyl-CoA Desaturase3
EC 1.14.19.13 8     

External Ids:    HGNC: 105711   Entrez Gene: 63192   Ensembl: ENSG000000991947   OMIM: 6040315   UniProtKB: O007673   

Export aliases for SCD gene to outside databases

Previous GC identifers: GC10P101000 GC10P101340 GC10P102238 GC10P101771 GC10P095735


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCD Gene:
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid.
Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been
detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on
chromosome 17. (provided by RefSeq, Feb 2012)

GeneCards Summary for SCD Gene: 
SCD (stearoyl-CoA desaturase (delta-9-desaturase)) is a protein-coding gene. Diseases associated with SCD include systemic primary carnitine deficiency disease, and familial combined hyperlipidemia, and among its related super-pathways are Fatty acid elongation and Regulation of Cholesterol Biosynthesis by SREBP (SREBF). GO annotations related to this gene include stearoyl-CoA 9-desaturase activity and iron ion binding. An important paralog of this gene is SCD5.

UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767
Function: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and
electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA
substrates including palmitoyl-CoA and stearoyl-CoA

Gene Wiki entry for SCD (Stearoyl-CoA desaturase-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCD gene promoter:
         COUP-TF1   NRSF form 1   COUP   HNF-4alpha2   NRSF form 2   HNF-4alpha1   SRY   PPAR-gamma1   COUP-TF   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): SCD promoter sequence
   Search SABiosciences Chromatin IP Primers for SCD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q23-q24

SCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCD gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102096:  view genomic region     (about GC identifiers)

Start:
102,106,772 bp from pter      End:
102,124,591 bp from pter
Size:
17,820 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767 (See protein sequence)
Recommended Name: Acyl-CoA desaturase  
Size: 359 amino acids; 41523 Da
Cofactor: Iron
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)
Secondary accessions: B2R5U0 D3DR68 Q16150 Q53GR9 Q5W037 Q5W038 Q6GSS4 Q96KF6 Q9BS07 Q9Y695

Explore the universe of human proteins at neXtProt for SCD: NX_O00767

Explore proteomics data for SCD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00767

  • 4/10 DME Specific Peptides for SCD (O00767) (see all 10)
     PTLVPWY  RDHRAHH  LVNSAAH  TWLVNSA 

    SCD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCD Protein Expression
    REFSEQ proteins: NP_005054.3  
    ENSEMBL proteins: 
     ENSP00000359380  

    Human Recombinant Protein Products for SCD: 
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    Novus Biologicals SCD Protein
    Novus Biologicals SCD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCD 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    SCD for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for SCD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FADS: Fatty acid desaturases

    3 InterPro protein domains:
     IPR015876 Fatty_acid_desaturase-1_core
     IPR001522 Fatty_acid_desaturase-1_C
     IPR005804 Fatty_acid_desaturase-1

    Graphical View of Domain Structure for InterPro Entry O00767

    ProtoNet protein and cluster: O00767

    1 Blocks protein domain: IPB001522 Fatty acid desaturase

    UniProtKB/Swiss-Prot: ACOD_HUMAN, O00767
    Domain: The histidine box domains may contain the active site and/or be involved in metal ion binding
    Similarity: Belongs to the fatty acid desaturase family


    SCD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACOD_HUMAN, O00767
    Function: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and
    electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA
    substrates including palmitoyl-CoA and stearoyl-CoA
    Catalytic activity: Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2
    H(2)O

         Genatlas biochemistry entry for SCD:
    stearol-CoA-desaturase

         Enzyme Number (IUBMB): EC 1.14.19.11 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004768stearoyl-CoA 9-desaturase activity IEA--
    GO:0005506iron ion binding IEA--
         
    SCD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SCD:
     Decreased G3BP1 protein expres 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Scd2):
     growth/size  homeostasis/metabolism  integument  limbs/digits/tail  liver/biliary system 
     mortality/aging 

    SCD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Scd2tm1Myz for SCD

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCD 

    miRNA
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    hsa-miR-194* hsa-miR-607 hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-199a-3p hsa-miR-605 hsa-miR-1260b hsa-miR-938
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SCD About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    oleate biosynthesis II (animals)0.32
    2Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    SREBP signalling0.37
    3SREBF and miR33 in cholesterol and lipid homeostasis
    SREBF and miR33 in cholesterol and lipid homeostasis
    4PPAR signaling pathway
    PPAR signaling pathway
    5Fatty Acid Biosynthesis
    Fatty Acid Biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SCD
        Glucose / Energy Metabolism

    5 BioSystems Pathways for SCD
        Adipogenesis
    SREBP signalling
    SREBF and miR33 in cholesterol and lipid homeostasis
    oleate biosynthesis II (animals)
    Fatty Acid Biosynthesis


    2         Kegg Pathways  (Kegg details for SCD):
        Biosynthesis of unsaturated fatty acids
    PPAR signaling pathway


    SCD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/75 Interacting proteins for SCD (O007673 ENSP000003593804) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACSL4O604883, ENSP000003397874I2D: score=1 STRING: ENSP00000339787
    ENSG00000258947Q135093I2D: score=1 
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    TUBB3Q135093I2D: score=1 
    UBCP0CG483, ENSP000003448184I2D: score=3 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006633fatty acid biosynthetic process IEA--

    SCD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCD (ACOD)

    10/36 HMDB Compounds for SCD (see all 36)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    10/48 Novoseek inferred chemical compound relationships for SCD gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stearoyl-coa 93 26 11352637 (3), 8914942 (2), 17363919 (2), 18989145 (2) (see all 16)
    sterculic acid 90.1 9 12504086 (4), 15910739 (1), 1320912 (1)
    fatty acid 85.5 235 18599738 (4), 18982375 (4), 18687433 (3), 18062827 (3) (see all 99)
    palmitoleate 84.4 12 14654089 (1), 18599738 (1), 11396956 (1), 11414710 (1) (see all 7)
    linoleic acid 76.6 34 11396956 (3), 17426927 (2), 16186393 (1), 15834635 (1) (see all 19)
    oleic acid 76.2 29 2340302 (1), 14654089 (1), 18599738 (1), 19056549 (1) (see all 22)
    stearic acid 74.9 9 14967823 (2), 18599738 (1), 10521790 (1), 14967817 (1) (see all 7)
    palmitoleic acid 71.7 9 18068341 (4), 18687433 (1), 18066610 (1)
    sterol 71.4 18 15460168 (1), 18982375 (1), 11414710 (1), 18181169 (1) (see all 15)
    acetyl-coa 67.2 15 19710915 (2), 11323427 (1), 17449569 (1), 19932008 (1) (see all 10)

    Search CenterWatch for drugs/clinical trials and news about SCD / ACOD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCD gene: 
    NM_005063.4  

    Unigene Cluster for SCD:

    Stearoyl-CoA desaturase (delta-9-desaturase)
    Hs.558396  [show with all ESTs]
    Unigene Representative Sequence: NM_005063
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370355(uc001kqy.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate SCD (see all 97):
    hsa-miR-194* hsa-miR-607 hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-199a-3p hsa-miR-605 hsa-miR-1260b hsa-miR-938
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    Additional mRNA sequence: 

    AB032261.1 AB208982.1 AF097514.1 AF109362.1 AF113690.1 AK222862.1 AK312312.1 BC005807.2 
    BC062303.1 S70284.1 Y13647.1 

    24/59 DOTS entries (see all 59):

    DT.97863820  DT.91809273  DT.95377395  DT.95376842  DT.95377467  DT.91775766  DT.97804439  DT.95377727 
    DT.454377  DT.95377527  DT.95134979  DT.95376748  DT.100746510  DT.100746528  DT.121296789  DT.100746388 
    DT.100874096  DT.100746342  DT.100746470  DT.100746492  DT.100746509  DT.121296820  DT.121296835  DT.91775761 

    24/1725 AceView cDNA sequences (see all 1725):

    AW003391 BQ004872 F03102 CA455374 BF198121 BQ683333 BM551997 CA426644 
    BU174390 BU168427 BM910250 AI554586 BP361268 BU541199 BQ684906 BM557648 
    BU556807 BM015526 BM669025 BQ691956 BQ877981 AI366719 BU538378 BM759077 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SCD    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:              -                                 
    SP2:                                                


    ECgene alternative splicing isoforms for SCD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCD expression in normal human tissues (normalized intensities)      SCD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTGATAC
    SCD Expression
    About this image


    SCD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/midbrain   
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Limb Bud
             limb/hindlimb   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             Ureter
             visceral organ   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi

    See SCD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCD

    SOURCE GeneReport for Unigene cluster: Hs.558396
        SABiosciences Expression via Pathway-Focused PCR Arrays including SCD (see all 8): 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat
              Insulin Resistance in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SCD gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scd25
    Scd11
    stearoyl-Coenzyme A desaturase 25
    stearoyl-Coenzyme A desaturase 11
    83.05(n)1
    85.31(a)1
      19 (37.98 cM)5
    202491  NM_009127.41  NP_033153.21 
     442936765 
    chicken
    (Gallus gallus)
    Aves SCD1 stearoyl-CoA desaturase (delta-9-desaturase) 70.52(n)
    68.17(a)
      395706  NM_204890.1  NP_990221.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCD6
    stearoyl-CoA desaturase (delta-9-desaturase)
    58(a)
    1 ↔ 1
    GL343388.1(136231-151024)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.86602 Xenopus laevis transcribed sequence with weak similarity more 70.81(n)    CB591503.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scd2 stearoyl-CoA desaturase (delta-9-desaturase) 73.52(n)   386661  AY217090.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta desat13
    CG86301
    fatty acid biosynthesis stearoyl-CoA
    desaturase3
    CG86301
    58(a)
    (best of 7)3
    56(n)1
    50.51(a)1
      87B113
    416291  NM_169500.11  NP_731781.11 
    worm
    (Caenorhabditis elegans)
    Secernentea fat-63 acyl-CoA desaturase 53(a)
    (best of 3)
      IV(11913716-11914891)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OLE1(YGL055W)4 Delta(9) fatty acid desaturase, required for monounsaturated more   --   7(398628-400160) 852825  NP_011460.1 


    ENSEMBL Gene Tree for SCD (if available)
    TreeFam Gene Tree for SCD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCD gene
    SCD52  
    1 SIMAP similar gene for SCD using alignment to 1 protein entry:     ACOD_HUMAN:
    SCD5

    SCD for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SCD
    PGOHUM00000237298 PGOHUM00000235526


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/644 SNPs in SCD are shown (see all 644)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824605431,2
    --102104829(+) TTTTGC/TTGTCA 1 -- us2k10--------
    rs1481871421,2
    --102104848(+) GTAACC/TATTGT 1 -- us2k10--------
    rs2005771741,2
    --102104882(+) AGACC-/AAAAAA 1 -- us2k10--------
    rs1151356581,2
    F--102104929(+) GACCAC/TTGTCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs6868841,2
    C--102105015(-) ggccCG/AGAGAA 1 -- us2k13Minor allele frequency- A:0.09NA EA 124
    rs1890740111,2
    --102105082(+) TCACCC/TGAGGT 1 -- us2k10--------
    rs1930207161,2
    --102105109(+) GCCTGA/GCCAAC 1 -- us2k10--------
    rs1411670651,2
    C--102105133(+) GTCTCC/TACTAA 1 -- us2k10--------
    rs1473563861,2
    --102105168(+) GGTGGC/TGCATG 1 -- us2k10--------
    rs1409933011,2
    C--102105173(+) CGCATG/TCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SCD (102106772 - 102124591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SCD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831961CNV Loss17160897
    nsv527448CNV Gain19592680
    nsv519672CNV Gain19592680


    Human Gene Mutation Database (HGMD): SCD
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604031    OMIM disorders: --

    20/34 diseases for SCD (see all 34):    About MalaCards
    systemic primary carnitine deficiency disease    familial combined hyperlipidemia    hypertriglyceridemia    prostate adenocarcinoma
    adrenoleukodystrophy    obesity    morbid obesity    insulin resistance
    skin disease    fatty liver disease    metabolic disorders    liver disease
    atherosclerosis    lung adenocarcinoma    adenocarcinoma    blindness
    prostatitis    cystic fibrosis    diabetes mellitus    ulcerative colitis

    2 diseases from the University of Copenhagen DISEASES database for SCD:
    Fatty liver disease     Diabetes mellitus

    SCD for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/17 Novoseek inferred disease relationships for SCD gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty liver 59.3 11 12538076 (1), 19691439 (1), 18952834 (1), 20022128 (1) (see all 9)
    obesity 57.8 35 18427563 (4), 17636091 (3), 17391062 (2), 19712485 (2) (see all 20)
    insulin resistance 52.5 17 18030445 (2), 18427563 (2), 20022128 (2), 19712485 (2) (see all 11)
    metabolic disorder 46.3 5 20137926 (1), 18068341 (1), 19632834 (1), 20205608 (1)
    insulin sensitivity 42.3 14 17636091 (4), 15855323 (2), 19478146 (2), 18286258 (1) (see all 6)
    hyperlipidemia 18.7 2 12538076 (1), 12401889 (1)
    prostatic adenocarcinoma 9.38 1 15609334 (1)
    cardiovascular diseases 8.25 1 20205608 (1)
    neoplastic transformation 7 2 15851470 (1), 15708362 (1)
    inflammation 6.88 9 18687433 (2), 17614770 (1), 20216310 (1), 18062827 (1) (see all 5)

    Genetic Association Database (GAD): SCD
    Human Genome Epidemiology (HuGE) Navigator: SCD (207 documents)

    Export disorders for SCD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCD gene, integrated from 9 sources (see all 307):
    (articles sorted by number of sources associating them with SCD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. (PubMed id 10229681)1, 2, 3, 9 Zhang L....Prouty S.M. (1999)
    2. Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues. (PubMed id 7909540)1, 2, 3 Li J.... Gilmour R.S. (1994)
    3. Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. (PubMed id 15662557)1, 4, 9 Liew C.F....McCarthy M.I. (2004)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. (PubMed id 11415448)1, 2 Zhang L.... Prouty S.M. (2001)
    10. Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma. (PubMed id 15855323)1, 9 Riserus U....Karpe F. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6319 HGNC: 10571 AceView: SCD Ensembl:ENSG00000099194 euGenes: HUgn6319
    ECgene: SCD Kegg: 6319 H-InvDB: SCD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCD gene:
    Search GeneIP for patents involving SCD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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