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Aliases for SCD Gene

Aliases for SCD Gene

  • Stearoyl-CoA Desaturase (Delta-9-Desaturase) 2 3
  • Fatty Acid Desaturase 2 3 4
  • Stearoyl-CoA Desaturase Opposite Strand 2 3
  • Acyl-CoA Desaturase 2 3
  • Delta(9)-Desaturase 3 4
  • Delta-9-Desaturase 2 3
  • Delta-9 Desaturase 3 4
  • EC 1.14.19.1 4 63
  • Predicted Protein Of HQ0998 3
  • Stearoyl-CoA Desaturase 4
  • MSTP008 3
  • FADS5 3
  • SCDOS 3
  • SCD1 3

External Ids for SCD Gene

Previous HGNC Symbols for SCD Gene

  • SCDOS

Previous GeneCards Identifiers for SCD Gene

  • GC10P101000
  • GC10P101340
  • GC10P102238
  • GC10P101771
  • GC10P102096
  • GC10P095735

Summaries for SCD Gene

Entrez Gene Summary for SCD Gene

  • This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Feb 2012]

GeneCards Summary for SCD Gene

SCD (Stearoyl-CoA Desaturase (Delta-9-Desaturase)) is a Protein Coding gene. Diseases associated with SCD include carnitine deficiency, systemic primary and obesity. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Glucose / Energy Metabolism. GO annotations related to this gene include iron ion binding and stearoyl-CoA 9-desaturase activity. An important paralog of this gene is SCD5.

UniProtKB/Swiss-Prot for SCD Gene

  • Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA

Gene Wiki entry for SCD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCD Gene

Genomics for SCD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCD Gene

Start:
100,347,015 bp from pter
End:
100,364,834 bp from pter
Size:
17,820 bases
Orientation:
Plus strand

Genomic View for SCD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCD Gene

Proteins for SCD Gene

  • Protein details for SCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00767-ACOD_HUMAN
    Recommended name:
    Acyl-CoA desaturase
    Protein Accession:
    O00767
    Secondary Accessions:
    • B2R5U0
    • D3DR68
    • Q16150
    • Q53GR9
    • Q5W037
    • Q5W038
    • Q6GSS4
    • Q96KF6
    • Q9BS07
    • Q9Y695

    Protein attributes for SCD Gene

    Size:
    359 amino acids
    Molecular mass:
    41523 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available

neXtProt entry for SCD Gene

Proteomics data for SCD Gene at MOPED

Post-translational modifications for SCD Gene

  • Ubiquitination at Lys162, Lys196, Lys209, and Lys341
  • Modification sites at PhosphoSitePlus

Other Protein References for SCD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SCD (SCD)

Domains for SCD Gene

Gene Families for SCD Gene

HGNC:
  • FADS :Fatty acid desaturases

Suggested Antigen Peptide Sequences for SCD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00767

UniProtKB/Swiss-Prot:

ACOD_HUMAN :
  • O00767
Domain:
  • The histidine box domains may contain the active site and/or be involved in metal ion binding
Family:
  • Belongs to the fatty acid desaturase family.
genes like me logo Genes that share domains with SCD: view

Function for SCD Gene

Molecular function for SCD Gene

GENATLAS Biochemistry:
stearol-CoA-desaturase
UniProtKB/Swiss-Prot CatalyticActivity:
Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O
UniProtKB/Swiss-Prot Function:
Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA

Enzyme Numbers (IUBMB) for SCD Gene

Gene Ontology (GO) - Molecular Function for SCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004768 stearoyl-CoA 9-desaturase activity IEA --
GO:0005506 iron ion binding IEA --
genes like me logo Genes that share ontologies with SCD: view
genes like me logo Genes that share phenotypes with SCD: view

Animal Models for SCD Gene

MGI Knock Outs for SCD:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCD

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SCD Gene

Localization for SCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCD Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCD Gene COMPARTMENTS Subcellular localization image for SCD gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 3
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2
chloroplast 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCD: view

Pathways for SCD Gene

genes like me logo Genes that share pathways with SCD: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SCD: view

Compounds for SCD Gene

(2) ApexBio Compounds for SCD Gene

Compound Action Cas Number
MK-8245 "SCD inhibitor,potent and liver-selective" [1030612-90-8]
PluriSIn #1 (NSC 14613) SCD1 inhibitor [91396-88-2]

(36) HMDB Compounds for SCD Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(48) Novoseek inferred chemical compound relationships for SCD Gene

Compound -log(P) Hits PubMed IDs
stearoyl-coa 93 22
sterculic acid 90.1 6
fatty acid 85.5 129
palmitoleate 84.4 7
linoleic acid 76.6 22
genes like me logo Genes that share compounds with SCD: view

Transcripts for SCD Gene

mRNA/cDNA for SCD Gene

(1725) Selected AceView cDNA sequences:
(11) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCD Gene

Stearoyl-CoA desaturase (delta-9-desaturase):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for SCD Gene

GeneLoc Exon Structure for
SCD
ECgene alternative splicing isoforms for
SCD

Expression for SCD Gene

mRNA expression in normal human tissues for SCD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCD Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.2), Adipose - Visceral (Omentum) (6.0), and Adipose - Subcutaneous (4.9).

Protein differential expression in normal tissues for SCD Gene

This gene is overexpressed in Fetal testis (11.1), Bone (10.3), Lung (10.0), Fetal Liver (8.0), Adrenal (7.5), and Spinal cord (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCD Gene

SOURCE GeneReport for Unigene cluster for SCD Gene Hs.558396

genes like me logo Genes that share expressions with SCD: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for SCD Gene

Orthologs for SCD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SCD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCD 35
  • 86.07 (n)
  • 86.07 (a)
-- 36
  • 84 (a)
OneToMany
SCD 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SCD 35
  • 89.42 (n)
  • 90.25 (a)
SCD 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scd1 35
  • 82.91 (n)
  • 85.07 (a)
Scd2 16
Scd1 36
  • 85 (a)
OneToMany
Scd2 36
  • 83 (a)
OneToMany
Scd3 36
  • 83 (a)
OneToMany
Scd4 36
  • 78 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SCD 35
  • 99.44 (n)
  • 98.89 (a)
SCD 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scd1 35
  • 83.61 (n)
  • 85.2 (a)
oppossum
(Monodelphis domestica)
Mammalia SCD 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCD 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCD 35
  • 70.52 (n)
  • 68.17 (a)
SCD 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCD 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scd 35
  • 64.69 (n)
  • 64.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8660 35
zebrafish
(Danio rerio)
Actinopterygii scd 35
scdb 35
  • 64.18 (n)
  • 63.96 (a)
scd 36
  • 61 (a)
OneToMany
scdb 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15531 37
  • 29 (a)
CG8630 37
  • 50 (a)
CG9743 37
  • 53 (a)
CG9747 37
  • 49 (a)
desat1 37
  • 58 (a)
desat2 37
  • 52 (a)
Fad2 37
  • 50 (a)
desat2 35
  • 56.69 (n)
  • 52.69 (a)
CG15531 36
  • 27 (a)
ManyToMany
CG8630 36
  • 37 (a)
ManyToMany
CG9743 36
  • 37 (a)
ManyToMany
CG9747 36
  • 32 (a)
ManyToMany
desat1 36
  • 47 (a)
ManyToMany
desat2 36
  • 47 (a)
ManyToMany
Fad2 36
  • 43 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fat-5 37
  • 46 (a)
fat-6 37
  • 53 (a)
fat-7 37
  • 53 (a)
fat-5 36
  • 41 (a)
ManyToMany
fat-6 36
  • 46 (a)
ManyToMany
fat-7 36
  • 46 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLE1 36
  • 22 (a)
OneToMany
OLE1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
CSA.9813 36
  • 46 (a)
ManyToMany
CSA.9947 36
  • 47 (a)
ManyToMany
Species with no ortholog for SCD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCD Gene

ENSEMBL:
Gene Tree for SCD (if available)
TreeFam:
Gene Tree for SCD (if available)

Paralogs for SCD Gene

Paralogs for SCD Gene

Selected SIMAP similar genes for SCD Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SCD Gene

genes like me logo Genes that share paralogs with SCD: view

Variants for SCD Gene

Sequence variations from dbSNP and Humsavar for SCD Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3071 -- 100,354,706(-) AAGTC(G/T)CAGGA intron-variant
rs7849 -- 100,362,846(-) TCAAC(A/G)TGAGC utr-variant-3-prime
rs11835 -- 100,362,544(+) GTTTT(C/T)TTCTT utr-variant-3-prime
rs15019 -- 100,364,450(-) AGGAT(A/C/T)CCAAA utr-variant-3-prime
rs15950 -- 100,364,645(-) TTCCG(G/T)GGCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SCD Gene

Variant ID Type Subtype PubMed ID
nsv831961 CNV Loss 17160897
nsv519672 CNV Gain 19592680
nsv527448 CNV Gain 19592680

Relevant External Links for SCD Gene

HapMap Linkage Disequilibrium report
SCD
Human Gene Mutation Database (HGMD)
SCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCD Gene

Disorders for SCD Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SCD Gene in MalaCards »

(2) Diseases for SCD Gene including...

(2) University of Copenhagen DISEASES for SCD Gene

(17) Novoseek inferred disease relationships for SCD Gene

Disease -log(P) Hits PubMed IDs
fatty liver 59.3 9
obesity 57.8 29
insulin resistance 52.5 16
metabolic disorder 46.3 4
insulin sensitivity 42.3 11

Relevant External Links for SCD

Genetic Association Database (GAD)
SCD
Human Genome Epidemiology (HuGE) Navigator
SCD
genes like me logo Genes that share disorders with SCD: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for SCD Gene

Publications for SCD Gene

  1. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. (PMID: 10229681) Zhang L. … Prouty S.M. (Biochem. J. 1999) 2 3 4 23
  2. Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. (PMID: 15662557) Liew C.F. … McCarthy M.I. (Diabetologia 2004) 3 23 48
  3. Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues. (PMID: 7909540) Li J. … Gilmour R.S. (Int. J. Cancer 1994) 2 3 4
  4. Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. (PMID: 11415448) Zhang L. … Prouty S.M. (Biochem. J. 2001) 3 4
  5. De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury. (PMID: 20032470) Collins J.M. … Frayn K.N. (J. Biol. Chem. 2010) 3 23

Products for SCD Gene

Sources for SCD Gene

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