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Aliases for SCCPDH Gene

Aliases for SCCPDH Gene

  • Saccharopine Dehydrogenase (Putative) 2 3
  • Saccharopine Dehydrogenase-Like Oxidoreductase 3
  • Probable Saccharopine Dehydrogenase 3
  • EC 1.-.-.- 4
  • CGI-49 3
  • NET11 3

External Ids for SCCPDH Gene

Previous GeneCards Identifiers for SCCPDH Gene

  • GC01P243214
  • GC01P244953
  • GC01P246887
  • GC01P217253

Summaries for SCCPDH Gene

GeneCards Summary for SCCPDH Gene

SCCPDH (Saccharopine Dehydrogenase (Putative)) is a Protein Coding gene. Diseases associated with SCCPDH include hyperlysinemia and cystinuria. Among its related pathways are lysine degradation II. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCCPDH Gene

Genomics for SCCPDH Gene

Regulatory Elements for SCCPDH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCCPDH Gene

246,724,047 bp from pter
246,768,137 bp from pter
44,091 bases
Plus strand

Genomic View for SCCPDH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCCPDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCCPDH Gene

Proteins for SCCPDH Gene

  • Protein details for SCCPDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Saccharopine dehydrogenase-like oxidoreductase
    Protein Accession:
    Secondary Accessions:
    • Q8TAR0
    • Q9Y363

    Protein attributes for SCCPDH Gene

    429 amino acids
    Molecular mass:
    47151 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCCPDH Gene

Proteomics data for SCCPDH Gene at MOPED

Post-translational modifications for SCCPDH Gene

  • Ubiquitination at Lys136, Lys220, Lys242, and Lys394
  • Modification sites at PhosphoSitePlus

Other Protein References for SCCPDH Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SCCPDH Gene

Domains for SCCPDH Gene

Protein Domains for SCCPDH Gene

Suggested Antigen Peptide Sequences for SCCPDH Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the saccharopine dehydrogenase family.
  • Belongs to the saccharopine dehydrogenase family.
genes like me logo Genes that share domains with SCCPDH: view

No data available for Gene Families for SCCPDH Gene

Function for SCCPDH Gene

Enzyme Numbers (IUBMB) for SCCPDH Gene

Gene Ontology (GO) - Molecular Function for SCCPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with SCCPDH: view

Phenotypes for SCCPDH Gene

GenomeRNAi human phenotypes for SCCPDH:
genes like me logo Genes that share phenotypes with SCCPDH: view

Animal Model Products

miRNA for SCCPDH Gene

miRTarBase miRNAs that target SCCPDH

No data available for Molecular function , Animal Models , Transcription Factor Targets and HOMER Transcription for SCCPDH Gene

Localization for SCCPDH Gene

Subcellular locations from

Jensen Localization Image for SCCPDH Gene COMPARTMENTS Subcellular localization image for SCCPDH gene
Compartment Confidence
cytosol 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SCCPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 20833797
GO:0005811 lipid particle IDA 14741744
GO:0016020 membrane IDA 19946888
GO:0030496 midbody IDA 15166316
genes like me logo Genes that share ontologies with SCCPDH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SCCPDH Gene

Pathways for SCCPDH Gene

SuperPathways for SCCPDH Gene

Superpath Contained pathways
1 lysine degradation II
genes like me logo Genes that share pathways with SCCPDH: view

Pathways by source for SCCPDH Gene

1 BioSystems pathway for SCCPDH Gene

Interacting Proteins for SCCPDH Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000355467 Q8NBX0-SCPDL_HUMAN for SCCPDH Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SCCPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SCCPDH: view

Drugs for SCCPDH Gene

(3) HMDB Compounds for SCCPDH Gene

Compound Synonyms Cas Number PubMed IDs
  • 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt
  • 1,4-Dihydronicotinamide adenine dinucleotide
  • (S)-N-(5-amino-5-carboxypentyl)-L-Glutamic acid
genes like me logo Genes that share compounds with SCCPDH: view

Transcripts for SCCPDH Gene


(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(404) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCCPDH Gene

Saccharopine dehydrogenase (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCCPDH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b
SP1: -
SP3: - -
SP4: -

Relevant External Links for SCCPDH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCCPDH Gene

mRNA expression in normal human tissues for SCCPDH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCCPDH Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCCPDH Gene

SOURCE GeneReport for Unigene cluster for SCCPDH Gene Hs.498397

genes like me logo Genes that share expressions with SCCPDH: view

Expression partners for SCCPDH Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCCPDH Gene

Orthologs for SCCPDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCCPDH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCCPDH 35
  • 89.12 (n)
  • 88.34 (a)
  • 89 (a)
(Canis familiaris)
Mammalia SCCPDH 35
  • 88.34 (n)
  • 89.07 (a)
  • 86 (a)
(Mus musculus)
Mammalia Sccpdh 35
  • 87.8 (n)
  • 87.18 (a)
Sccpdh 16
Sccpdh 36
  • 87 (a)
(Pan troglodytes)
Mammalia SCCPDH 35
  • 99.15 (n)
  • 98.83 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100910414 35
  • 86.71 (n)
  • 85.78 (a)
(Monodelphis domestica)
Mammalia SCCPDH 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia SCCPDH 36
  • 78 (a)
(Gallus gallus)
Aves SCCPDH 35
  • 70.35 (n)
  • 69.41 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia SCCPDH 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sccpdh 35
  • 69.48 (n)
  • 69.25 (a)
Str.94 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7722 35
(Danio rerio)
Actinopterygii sbcb4 35
sccpdha 35
  • 63 (n)
  • 61.72 (a)
SCCPDH (2 of 3) 36
  • 53 (a)
sccpdha 36
  • 54 (a)
sccpdhb 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002652 35
  • 50.72 (n)
  • 44.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2604 35
  • 48.66 (n)
  • 40.88 (a)
CG2604 36
  • 38 (a)
CG5167 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea F22F7.1 35
  • 47.57 (n)
  • 41.02 (a)
F22F7.1 36
  • 39 (a)
F22F7.2 36
  • 33 (a)
Y50D4B.2 36
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G39410 35
  • 48.55 (n)
  • 37.44 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07563 35
  • 43.12 (n)
  • 31.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for SCCPDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCCPDH Gene

Gene Tree for SCCPDH (if available)
Gene Tree for SCCPDH (if available)

Paralogs for SCCPDH Gene

No data available for Paralogs for SCCPDH Gene

Variants for SCCPDH Gene

Sequence variations from dbSNP and Humsavar for SCCPDH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3314 -- 246,767,755(-) AAAAA(C/T)AGCAA utr-variant-3-prime
rs7779 - 246,767,262(-) AATAC(C/G)GTGTT missense, reference
rs13150 -- 246,760,028(-) AAAAA(A/G)AAAAG reference, synonymous-codon
rs13274 -- 246,767,628(-) CACCC(C/T)CGATG utr-variant-3-prime
rs1127098 -- 246,759,088(+) ATGGG(A/G)TCTGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SCCPDH Gene

Variant ID Type Subtype PubMed ID
esv2667587 CNV Deletion 23128226
nsv873421 CNV Gain 21882294
nsv873422 CNV Gain 21882294
nsv523531 CNV Gain 19592680
esv2660077 CNV Deletion 23128226
nsv873423 CNV Gain 21882294
esv2443936 CNV Deletion 19546169
esv1933268 CNV Deletion 18987734
esv2727518 CNV Deletion 23290073
esv1000885 CNV Deletion 20482838
esv2743351 CNV Deletion 23290073
esv1589537 CNV Deletion 17803354
nsv160725 CNV Loss 16902084

Relevant External Links for SCCPDH Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCCPDH Gene

Disorders for SCCPDH Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SCCPDH Gene in MalaCards »

(2) Diseases for SCCPDH Gene

(2) University of Copenhagen DISEASES for SCCPDH Gene

Relevant External Links for SCCPDH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SCCPDH: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SCCPDH Gene

Publications for SCCPDH Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SCCPDH Gene

Sources for SCCPDH Gene

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