SCCPDH Gene
protein-coding GIFtS: 49
GCID: GC01P246887
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|
saccharopine dehydrogenase (putative)
| |
Aliases
for SCCPDH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Saccharopine Dehydrogenase (Putative)1 2 | | Probable Saccharopine Dehydrogenase2 | | NET111 2 | | Saccharopine Dehydrogenase-Like Oxidoreductase2 | | CGI-491 | | EC 1.-.-.-3 | | RP11-439E19.22 | | |
Export aliases for SCCPDH gene to outside databasesPrevious GC identifers: GC01P243214 GC01P244953 GC01P217253 |
Summaries
for SCCPDH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SCCPDH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCCPDH gene promoter:
TBP NRSF form 1 NRSF form 2 Nkx5-1 GATA-1 E47 HFH-1 Hand1 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCCPDH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCCPDH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44SCCPDH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P246887: view genomic region
(about GC identifiers)
Start:
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246,887,349 bp from pter |
End:
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246,931,439 bp from pter |
Size:
|
44,091 bases |
Orientation:
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plus strand |
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Proteins
for SCCPDH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCPDL_HUMAN, Q8NBX0 (See
protein sequence)Recommended Name: Saccharopine dehydrogenase-like oxidoreductase Size: 429 amino acids; 47151 Da
Secondary accessions: Q8TAR0 Q9Y363Explore the universe of human proteins at neXtProt for SCCPDH: NX_Q8NBX0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NBX0
SCCPDH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057086.2
ENSEMBL proteins: ENSP00000355467
Human Recombinant Protein Products for SCCPDH:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SCCPDH for ontologies About GeneDecksing
SCCPDH Antibody Products:
Assay Products for SCCPDH: |
Protein
Domains /
Families
for SCCPDH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCCPDH for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NBX0ProtoNet protein and cluster: Q8NBX0 UniProtKB/Swiss-Prot: SCPDL_HUMAN, Q8NBX0Similarity: Belongs to the saccharopine dehydrogenase family |
Function
for SCCPDH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 1.-.-.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- |
SCCPDH for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for SCCPDH:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCCPDH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCCPDH
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SCCPDH (NM_016002) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCCPDH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCCPDH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCCPDH |
|
Pathways & Interactions
for SCCPDH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | lysine degradation II | |
1  BioSystems Pathway for SCCPDH
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCCPDH
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for SCCPDH (Q8NBX03 ENSP000003554674) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SCCPDH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SCCPDH
3 HMDB Compounds for SCCPDH About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| NAD | 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28) | 53-84-9 | -- | | NADH | 1,4-Dihydronicotinamide adenine dinucleotide (see all 17) | 58-68-4 | -- | | Saccharopine | (S)-N-(5-amino-5-carboxypentyl)-L-Glutamic acid (see all 11) | 997-68-2 | -- |
Search CenterWatch for drugs/clinical trials and news about SCCPDH / SCPDL
|
Transcripts
for SCCPDH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCCPDH gene: NM_016002.2 Unigene Cluster for SCCPDH: Saccharopine dehydrogenase (putative) Hs.498397 [show with all ESTs]Unigene Representative Sequence: NM_0160021 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000366510(uc001ibr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCCPDH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCCPDH
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SCCPDH (NM_016002) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCCPDH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCCPDH |
Additional cDNA sequence: AF151807.1 AK075178.1 BC026185.2 19 DOTS entries: DT.118787 DT.92447890 DT.121432702 DT.121432736 DT.121432724 DT.100821358 DT.86857815 DT.87002854 DT.95102379 DT.95158262 DT.100651243 DT.100821351 DT.121432727 DT.121432728 DT.40202779 DT.75125332 DT.95158269 DT.95158272 DT.95367580 24/404 AceView cDNA sequences (see all 404): BU728961 BU687845 BG252111 AA873611 CB158580 CD558066 AJ243243 BF222280 CB241631 CA430629 CR602614 BF222279 N58769 BI827193 AI126957 AJ708649 CA447559 CB306041 AI307122 BQ719099 CR621663 AA426125 AA873850 CN484105
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SCCPDH About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for SCCPDH
|
Expression
for SCCPDH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCCPDH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCTTCTAA
About this image
See SCCPDH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCCPDH
SOURCE GeneReport for Unigene cluster: Hs.498397
SABiosciences Custom PCR Arrays for SCCPDH
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCCPDH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCCPDH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCCPDH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCCPDH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCCPDH |
Orthologs
for SCCPDH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SCCPDH gene from 9/28 species (see all 28) About this table
ENSEMBL Gene Tree for SCCPDH (if available)
TreeFam Gene Tree for SCCPDH (if available) |
Paralogs
for SCCPDH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SCCPDH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCCPDH (246887349 - 246931439 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SCCPDH
1 CNV: 97713
3 Indels: 24151 44550 11447 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCCPDH |
|
Disorders
/ Diseases
for SCCPDH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCCPDH for disorders About GeneDecksing
5  diseases for SCCPDH: About MalaCardshyperlysinemia cystinuria tuberculosis malaria
mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: SCCPDH (1 document)
Export disorders for SCCPDH gene to outside databases
|
Publications
for SCCPDH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCCPDH gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with SCCPDH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for SCCPDH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCCPDH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCCPDH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCCPDH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SCCPDH | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SCCPDH gene:
Search GeneIP for patents involving SCCPDH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCCPDH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SCCPDH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCCPDH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCCPDH | | | OriGene Protein Over-expression Lysate for SCCPDH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SCCPDH | | OriGene 3'-UTR Clone for SCCPDH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCCPDH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCCPDH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SCCPDH | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SCCPDH | | OriGene Custom Protein Services for SCCPDH | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCCPDH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCCPDH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCCPDH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCCPDH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCCPDH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCCPDH |
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| | | | Search Tocris compounds for SCCPDH |
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 | | | SCCPDH Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCCPDH |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SCCPDH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCCPDH |
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