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Aliases for SCCPDH Gene

Aliases for SCCPDH Gene

  • Saccharopine Dehydrogenase (Putative) 2 3 5
  • Probable Saccharopine Dehydrogenase 3
  • EC 1.-.-.- 4
  • CGI-49 3
  • NET11 3

External Ids for SCCPDH Gene

Previous GeneCards Identifiers for SCCPDH Gene

  • GC01P243214
  • GC01P244953
  • GC01P246887
  • GC01P217253

Summaries for SCCPDH Gene

GeneCards Summary for SCCPDH Gene

SCCPDH (Saccharopine Dehydrogenase (Putative)) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCCPDH Gene

Genomics for SCCPDH Gene

Regulatory Elements for SCCPDH Gene

Promoters for SCCPDH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCCPDH on UCSC Golden Path with GeneCards custom track

Genomic Location for SCCPDH Gene

Chromosome:
1
Start:
246,724,047 bp from pter
End:
246,768,137 bp from pter
Size:
44,091 bases
Orientation:
Plus strand

Genomic View for SCCPDH Gene

Genes around SCCPDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCCPDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCCPDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCCPDH Gene

Proteins for SCCPDH Gene

  • Protein details for SCCPDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBX0-SCPDL_HUMAN
    Recommended name:
    Saccharopine dehydrogenase-like oxidoreductase
    Protein Accession:
    Q8NBX0
    Secondary Accessions:
    • Q8TAR0
    • Q9Y363

    Protein attributes for SCCPDH Gene

    Size:
    429 amino acids
    Molecular mass:
    47151 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCCPDH Gene

Proteomics data for SCCPDH Gene at MOPED

Post-translational modifications for SCCPDH Gene

  • Ubiquitination at Lys 136, Lys 242, and Lys 394
  • Modification sites at PhosphoSitePlus

Other Protein References for SCCPDH Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SCCPDH Gene

Domains & Families for SCCPDH Gene

Protein Domains for SCCPDH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCCPDH Gene

Graphical View of Domain Structure for InterPro Entry

Q8NBX0

UniProtKB/Swiss-Prot:

SCPDL_HUMAN :
  • Belongs to the saccharopine dehydrogenase family.
Family:
  • Belongs to the saccharopine dehydrogenase family.
genes like me logo Genes that share domains with SCCPDH: view

No data available for Gene Families for SCCPDH Gene

Function for SCCPDH Gene

Enzyme Numbers (IUBMB) for SCCPDH Gene

genes like me logo Genes that share phenotypes with SCCPDH: view

Animal Model Products

miRNA for SCCPDH Gene

miRTarBase miRNAs that target SCCPDH

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCCPDH Gene

Localization for SCCPDH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCCPDH Gene COMPARTMENTS Subcellular localization image for SCCPDH gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SCCPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 20833797
GO:0005811 lipid particle IDA 14741744
GO:0030496 midbody IDA 15166316
genes like me logo Genes that share ontologies with SCCPDH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SCCPDH Gene

Pathways & Interactions for SCCPDH Gene

SuperPathways for SCCPDH Gene

No Data Available

Interacting Proteins for SCCPDH Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355467%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000355467 Q8NBX0-SCPDL_HUMAN for SCCPDH Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SCCPDH Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCCPDH Gene

Drugs & Compounds for SCCPDH Gene

(2) Drugs for SCCPDH Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NAD Pharma Full agonist, Agonist 0
NADH Nutra 0

(1) Additional Compounds for SCCPDH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
saccharopine
  • (S)-N-(5-amino-5-carboxypentyl)-L-Glutamic acid
  • epsilon-N-(L-Glutar-2-yl)-L-lysine
  • L-N-(5-Amino-5-carboxypentyl)-Glutamic acid
  • L-Saccharopin
  • L-Saccharopine
997-68-2
genes like me logo Genes that share compounds with SCCPDH: view

Transcripts for SCCPDH Gene

mRNA/cDNA for SCCPDH Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(404) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCCPDH Gene

Saccharopine dehydrogenase (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCCPDH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for SCCPDH Gene

GeneLoc Exon Structure for
SCCPDH
ECgene alternative splicing isoforms for
SCCPDH

Expression for SCCPDH Gene

mRNA expression in normal human tissues for SCCPDH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCCPDH Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SCCPDH Gene



SOURCE GeneReport for Unigene cluster for SCCPDH Gene Hs.498397

genes like me logo Genes that share expression patterns with SCCPDH: view

Protein tissue co-expression partners for SCCPDH Gene

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCCPDH Gene

Orthologs for SCCPDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCCPDH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCCPDH 36
  • 99 (a)
OneToOne
SCCPDH 35
  • 99.15 (n)
  • 98.83 (a)
cow
(Bos Taurus)
Mammalia SCCPDH 36
  • 89 (a)
OneToOne
SCCPDH 35
  • 89.12 (n)
  • 88.34 (a)
dog
(Canis familiaris)
Mammalia SCCPDH 35
  • 88.34 (n)
  • 89.07 (a)
SCCPDH 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sccpdh 36
  • 87 (a)
OneToOne
Sccpdh 16
Sccpdh 35
  • 87.8 (n)
  • 87.18 (a)
oppossum
(Monodelphis domestica)
Mammalia SCCPDH 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCCPDH 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910414 35
  • 86.71 (n)
  • 85.78 (a)
chicken
(Gallus gallus)
Aves SCCPDH 35
  • 70.35 (n)
  • 69.41 (a)
SCCPDH 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCCPDH 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7722 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sccpdh 35
  • 69.48 (n)
  • 69.25 (a)
Str.94 35
zebrafish
(Danio rerio)
Actinopterygii sbcb4 35
sccpdha 35
  • 63 (n)
  • 61.72 (a)
SCCPDH (2 of 3) 36
  • 53 (a)
OneToMany
sccpdha 36
  • 54 (a)
OneToMany
sccpdhb 36
  • 59 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002652 35
  • 50.72 (n)
  • 44.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2604 36
  • 38 (a)
OneToMany
CG5167 36
  • 37 (a)
OneToMany
CG2604 35
  • 48.66 (n)
  • 40.88 (a)
worm
(Caenorhabditis elegans)
Secernentea F22F7.1 36
  • 39 (a)
OneToMany
F22F7.2 36
  • 33 (a)
OneToMany
Y50D4B.2 36
  • 34 (a)
OneToMany
F22F7.1 35
  • 47.57 (n)
  • 41.02 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G39410 35
  • 48.55 (n)
  • 37.44 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07563 35
  • 43.12 (n)
  • 31.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for SCCPDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCCPDH Gene

ENSEMBL:
Gene Tree for SCCPDH (if available)
TreeFam:
Gene Tree for SCCPDH (if available)

Paralogs for SCCPDH Gene

No data available for Paralogs for SCCPDH Gene

Variants for SCCPDH Gene

Sequence variations from dbSNP and Humsavar for SCCPDH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7779 - 246,767,262(-) AATAC(A/C/G/T)GTGTT reference, missense
rs3314 -- 246,767,755(-) AAAAA(C/T)AGCAA utr-variant-3-prime
rs1127098 -- 246,759,088(+) ATGGG(A/G)TCTGA reference, synonymous-codon
rs1127149 -- 246,767,572(+) AGCTG(A/G)CAGGT utr-variant-3-prime
rs3007318 -- 246,729,474(+) tattt(C/T)tccta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCCPDH Gene

Variant ID Type Subtype PubMed ID
esv2667587 CNV Deletion 23128226
nsv873421 CNV Gain 21882294
nsv873422 CNV Gain 21882294
nsv523531 CNV Gain 19592680
esv2660077 CNV Deletion 23128226
nsv873423 CNV Gain 21882294
esv2443936 CNV Deletion 19546169
esv1933268 CNV Deletion 18987734
esv2727518 CNV Deletion 23290073
esv1000885 CNV Deletion 20482838
esv2743351 CNV Deletion 23290073
esv1589537 CNV Deletion 17803354
nsv160725 CNV Loss 16902084

Variation tolerance for SCCPDH Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCCPDH Gene

HapMap Linkage Disequilibrium report
SCCPDH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCCPDH Gene

Disorders for SCCPDH Gene

Relevant External Links for SCCPDH

Genetic Association Database (GAD)
SCCPDH
Human Genome Epidemiology (HuGE) Navigator
SCCPDH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCCPDH

No disorders were found for SCCPDH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCCPDH Gene

Publications for SCCPDH Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for SCCPDH Gene

Sources for SCCPDH Gene

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