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SERPINB3 Gene

protein-coding GIFtS: 56

GC18M059473

serpin peptidase inhibitor, clade B (ovalbumin), member 3
(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: SCC, SCCA1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
HsT1196 ^¹, ²
SCC ^²
SCCA ^³
SCCA-1 ^², ³
SCCA-PD ^²
SCCA1 ^², ³, ⁵
T4-A ^¹, ²

Descriptions
Protein T4-A ^³
Squamous cell carcinoma antigen 1 ^², ³
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3 ^¹, ²
serpin peptidase inhibitor, clade B (ovalbumin), member 3 ^²

External Ids
HGNC: 10569¹
Entrez Gene: 6317²
UniProtKB: P29508³
Ensembl: ENSG00000206073⁷

Search outside databases for aliases for SERPINB3 gene

Previous GC identifers: GC18M061161 GC18M061295 GC18M059455 GC18M059457

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508

Function: May act as a protease inhibitor to modulate the host immune response against tumor cells

Gene Wiki entry for SERPINB3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SERPINB3 gene

Entrez Gene cytogenetic band: 18q21.3 Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.3

SERPINB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M059473: (about GC identifiers)

Start:	59,473,411 bp from pter
End:	59,480,170 bp from pter
Size:	6,760 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000018.8 NT_025028.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508 (See protein sequence)

Recommended Name: Serpin B3

Size: 390 amino acids; 44565 Da

Subcellular location: Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at

a low level

Developmental stage: Its expression is closely related to cellular differentiation in both normal

and malignant squamous cells

PDB structures from and Proteopedia :

2ZV6 (3D)

Secondary accessions: Q53H28 Q53YB5 Q86VF3 Q86W04 Q8IWL4 Q8IXI3 Q96J21 Q9BYF8

Alternative splicing: 2 isoforms: P29508-1 P29508-2

REFSEQ proteins: NP_008850.1

ENSEMBL proteins:

ENSP00000348795 ENSP00000343445

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SerpinB3)
	Human Recombinant Proteins from Abnova (SERPINB3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for SERPINB3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SERPINB3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SerpinB3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SERPINB3)
	Novus Biologicals Antibodies for SERPINB3

Assays for SERPINB3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P29508

ProtoNet protein and cluster: P29508

1 Blocks protein family: IPB000215 Serpin

UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508

Similarity: Belongs to the serpin family. Ov-serpin subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SERPINB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SERPINB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006919

Applied Biosystems Silencer® siRNAs for SERPINB3

Sigma-Aldrich siRNA and siRNA Panels for SERPINB3

Sigma-Aldrich shRNA for SERPINB3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SERPINB3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006919
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006919
untagged cDNA clones in CMV expression vector (see all 2): NM_006919

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006919

UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508

Function: May act as a protease inhibitor to modulate the host immune response against tumor cells

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004867	serine-type endopeptidase inhibitor activity	TAS	7724531
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for SERPINB3

5/15 Interacting proteins for SERPINB3 (ENSP00000343445³ P29508^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 15 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
USF2	Q15853¹	EBI-359110, EBI-1055994
TNFRSF1B	P20333²	MINT-49424
CTSG	ENSP00000216336³	STRING (score=.964)
CTSL1	ENSP00000365073³	STRING (score=.871)
MAPK8	ENSP00000363291³	STRING (score=.844)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SERPINB3
1 Novoseek chemical compound relationship for SERPINB3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
scca1	99.29	223	12949073 (8), 10653592 (7), 14630915 (7), 10852705 (7) (see all 46)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SERPINB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SERPINB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006919

Sigma-Aldrich siRNA and siRNA Panels for SERPINB3

Sigma-Aldrich shRNA for SERPINB3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006919

REFSEQ mRNAs for SERPINB3 gene:

NM_006919.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006919

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006919
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006919
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006919

Additional cDNA sequence:

AB046399.1 AF428135.1 AF428136.1 AF428137.1 AF428138.1 AF428139.1 AF461146.1 AJ515706.1

AK222746.1 AK222753.1 AK307261.1 AK308383.1 AK310948.1 AK314805.1 AY190327.1 AY245778.1

AY245781.1 BC005224.1 BC008483.1 BT006748.1 EU852041.1 S66896.1 U19556.1

4 DOTS entries:

DT.453388 DT.100788918 DT.92432754 DT.97774794

24/135 AceView cDNA sequences (see all 135 ):

AA861180 BM968440 BT006748 BC008483 BU686141 U19556 BC005224 BQ028405

BE156503 U19557 BU674965 BM975848 AB046399 X89015 CB129418 NM_006919

BX477537 BU687165 BE720615 S66896 BM968451 BU685771 AI081890 AB046400

highest scoring ESTs for SERPINB3:

AB046399 AW872674 DA590593 DB228764 DB233847 S66896 AK222746 AK222753 AW178758 AW381318

Unigene Cluster for SERPINB3:

Serpin peptidase inhibitor, clade B (ovalbumin), member 3

Hs.227948 [show with all ESTs]

Unigene Representative Sequence: NM_006919

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000356424 ENST00000341074

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SERPINB3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SERPINB3

¹ / ² / ³

10 probe-sets matching SERPINB3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1343_s_at²^{, 3}	U95-A	2	1.00	0.62	0.74	0.94	S66896	0.80	0.70	0.75	1
1549_s_at²^{, 3}	U95-A	2	1.00	0.50	0.66	1.24	U19557	0.60	0.30	0.47	2
209720_s_at²^{, 3}	U133-A	2	1.00	0.64	--	--	BC005224	0.60	0.62	0.61	1
209719_x_at²^{, 3}	U133-A	2	1.00	0.55	--	--	U19556	0.40	0.50	0.45	1
211906_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	AB046400	0.20	0.17	0.18	2
210413_x_at²^{, 3}	U133-A	2	1.00	0.50	--	--	U19557	0.60	0.30	0.47	2
209720_s_at²	U133Plus2	2	1.00	0.64	--	--	--	--	--	--	--
209719_x_at²	U133Plus2	2	1.00	0.55	--	--	--	--	--	--	--
211906_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
210413_x_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.227948
Expression variation in blood from EXPOLDB for SERPINB3
UniProtKB/Swiss-Prot: SPB3_HUMAN, P29508
Tissue specificity: Squamous cells. Expressed in some hepatocellular carcinoma (at protein level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for SERPINB3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	SERPINB3¹	--	serpin peptidase inhibitor, clade B (ovalbumin), member more	97.95(n) 96.67(a)	740098 XM_001141918.1 XP_001141918.1
mouse (Mus musculus)	Serpinb3d¹	--	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), more	71.5(n) 60.1(a)	394252 NM_201376.1 NP_958764.1
chicken (Gallus gallus)	SERPINB3¹	--	serpin peptidase inhibitor, clade B (ovalbumin), member more	55.9(n) 45.74(a)	420897 NM_001031001.1 NP_001026172.1
fruit fly (Drosophila melanogaster)	Spn1³	42D4	serpin	36(a) (best of 15)	--
worm (Caenorhabditis elegans)	srp-7³	V(8184025-8185481)	serine protease inhibitor	31(a) (best of 3)	--

About this table Species with no ortholog for SERPINB3

ENSEMBL Gene Tree for SERPINB3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SERPINB3 gene

SERPINB10² SERPINB12² SERPINB2² SERPINB4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/79 NCBI SNPs in SERPINB3 are shown (see all 79 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 13)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs3180227^1,2	A,C,F,H	59473992(-)	`AGTAGG/CATTCG`	1	A/G	mis¹		13		MN EU EA WA	1428
--	rs1065205^1,2	C,F,H,O	59473975(-)	`CACCTA/GCTTCA`	1	T/A	mis¹ ese³		9		MN EU EA WA	1014
	rs4941210^1,2	A,C,F,H	59473023(+)	`CCAGGC/TTGTTT`	1	--	ng5¹		4		EU EA WA	418
--	rs11664693^1,2	C,F,H	59481552(+)	`acaaaG/Cttgtg`	1	--	ng3¹		4		EU EA WA	418
--	rs7241152^1,2	C,F,H	59481353(+)	`ATTCCA/TGTGTT`	1	--	ng3¹		4		EU EA WA	416
--	rs1047257^1,2	F	59473845(-)	`CATTTG/AGAAAA`	1	--	ut3¹		1		MN	184
--	rs9320025^1,2	C	59481853(+)	`ctttaA/Ttcata`	1	--	ng3¹		0	--	--	--	--
--	rs470750^1,2	F	59480157(-)	`AGGGAA/GAGGCA`	1	--	ut5¹ tfbs³ trp³		1		MN	184
--	rs1047264^1,2	F	59473575(-)	`TGTTTG/CTGACC`	1	--	ut3¹		1		MN	184
--	rs7240852^1,2	A	59480996(+)	`tttatC/Tagggg`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for SERPINB3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600517

10/25 Novoseek disease relationships for SERPINB3 gene (see all 25 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	83.71	109	11182054 (5), 7687515 (2), 10653592 (2), 12743426 (2) (see all 68)
cervical squamous cell carcinoma	66.44	4	18097581 (2), 9817979 (1), 10873412 (1)
hepatocellular carcinoma	50.99	6	16550605 (1), 18638391 (1), 14993646 (1), 17893121 (1) (see all 5)
squamous cell cancer	48.27	1	11241309 (1)
cervical cancer	35.52	4	16641548 (3), 17291250 (1)
tumors	35.46	29	2020345 (2), 1725572 (2), 12437110 (2), 17238969 (2) (see all 23)
chronic liver disease	33.43	2	18638391 (1), 18657489 (1)
cancer	33.35	29	11369142 (3), 11241309 (2), 15286970 (2), 17364691 (1) (see all 16)
cirrhosis	30.85	6	18657489 (1), 15887222 (1)
laryngeal cancer	29.76	1	10845558 (1)

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Human Genome Epidemiology Navigator: SERPINB3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/111 PubMed articles for SERPINB3 gene (see all 111 ):

A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PubMed id 7724531)^{1, 2, 3, 4} Schneider S.S....Silverman G.A. (1995)
Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. (PubMed id 14970861)^{1, 3, 4} Pontisso P....Fassina G. (2004)
Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PubMed id 10956412)^{1, 3, 4} Uemura Y.... Silverman G.A. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Binding of HBV to cells is mediated by SCCA1 but does not require the reactive site loop. (PubMed id 12975381)^{3, 4} Moore P.L.... Harrison T.J. (2003)
Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. (PubMed id 1958219)^{3, 4} Suminami Y.... Kato H. (1991)
Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus. (PubMed id 14993646)^{1, 3} Ruvoletto M.G....Pontisso P. (2004)
Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. (PubMed id 10653592)^{1, 3} Cataltepe S....Upton M.P. (2000)
Expression pattern of squamous cell carcinoma antigen in oesophageal dysplasia and squamous cell carcinoma. (PubMed id 17523076)^{1, 3} Parenti A....De Caro R. (2007)
Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1. (PubMed id 12949073)^{1, 3} Masumoto K....Izuhara K. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6317	HGNC: 10569	AceView: SERPINB4andSERPINB3	Ensembl:ENSG00000206073	euGenes: HUgn6317
ECgene: SERPINB3	H-InvDB: SERPINB3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for SERPINB3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SERPINB3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SERPINB3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SERPINB3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SERPINB3		Antibodies for SERPINB3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SERPINB3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SERPINB3)
	Antibodies (SERPINB3)
	Chimera RNAi (SERPINB3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (SerpinB3)

Search OriGene for SERPINB3

Search Tocris compounds for SERPINB3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SERPINB3

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SERPINB3 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for SERPINB3

Summaries
for SERPINB3

Genomic Location
for SERPINB3

Proteins
for SERPINB3

Protein Domains/
Families
for SERPINB3

Gene Function
for SERPINB3

Pathways & Interactions
for SERPINB3

Drugs & Compounds
for SERPINB3

Transcripts
for SERPINB3

Expression
for SERPINB3

Orthologs
for SERPINB3

Paralogs
for SERPINB3

SNPs/Variants
for SERPINB3

Disorders & Mutations
for SERPINB3

Medical News
for SERPINB3

Publications
for SERPINB3

Search for SERPINB3

Genome Databases showing SERPINB3

Other Databases showing SERPINB3

Specialized Databases showing SERPINB3

Licensable Technologies
for SERPINB3

Services
for SERPINB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SERPINB3 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor SERPINB3

Summariesfor SERPINB3

Genomic Locationfor SERPINB3

Proteinsfor SERPINB3

Protein Domains/Familiesfor SERPINB3

Gene Functionfor SERPINB3

Pathways & Interactionsfor SERPINB3

Drugs & Compoundsfor SERPINB3

Transcriptsfor SERPINB3

Expression for SERPINB3

Orthologsfor SERPINB3

Paralogsfor SERPINB3

SNPs/Variantsfor SERPINB3

Disorders & Mutationsfor SERPINB3

Medical Newsfor SERPINB3

Publicationsfor SERPINB3

Search for SERPINB3

Genome Databases showing SERPINB3

Other Databases showing SERPINB3

Specialized Databases showing SERPINB3

Licensable Technologiesfor SERPINB3

Servicesfor SERPINB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SERPINB3

Summaries
for SERPINB3

Genomic Location
for SERPINB3

Proteins
for SERPINB3

Protein Domains/
Families
for SERPINB3

Gene Function
for SERPINB3

Pathways & Interactions
for SERPINB3

Drugs & Compounds
for SERPINB3

Transcripts
for SERPINB3

Expression
for SERPINB3

Orthologs
for SERPINB3

Paralogs
for SERPINB3

SNPs/Variants
for SERPINB3

Disorders & Mutations
for SERPINB3

Medical News
for SERPINB3

Publications
for SERPINB3

Licensable Technologies
for SERPINB3

Services
for SERPINB3