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Aliases for SCARF2 Gene

Aliases for SCARF2 Gene

  • Scavenger Receptor Class F, Member 2 2 3
  • Scavenger Receptor Expressed By Endothelial Cells 2 Protein 3 4
  • SRECRP-1 3 4
  • SREC-II 3 4
  • SREC2 3 4
  • SREPCR 4
  • VDEGS 3
  • NSR1 3

External Ids for SCARF2 Gene

Previous GeneCards Identifiers for SCARF2 Gene

  • GC22M017481
  • GC22M019103
  • GC22M020778
  • GC22M004042

Summaries for SCARF2 Gene

Entrez Gene Summary for SCARF2 Gene

  • The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCARF2 Gene

SCARF2 (Scavenger Receptor Class F, Member 2) is a Protein Coding gene. Diseases associated with SCARF2 include van den ende-gupta syndrome and van den ende-gupta sndrome. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is MEGF11.

UniProtKB/Swiss-Prot for SCARF2 Gene

  • Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARF2 Gene

Genomics for SCARF2 Gene

Regulatory Elements for SCARF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCARF2 Gene

20,424,584 bp from pter
20,437,859 bp from pter
13,276 bases
Minus strand

Genomic View for SCARF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCARF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARF2 Gene

Proteins for SCARF2 Gene

  • Protein details for SCARF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Scavenger receptor class F member 2
    Protein Accession:
    Secondary Accessions:
    • E5RFB8
    • Q58A83
    • Q8IXF3
    • Q9BW74

    Protein attributes for SCARF2 Gene

    870 amino acids
    Molecular mass:
    92479 Da
    Quaternary structure:
    • Homophilic and heterophilic interaction via its extracellular domain. Interacts with SCARF1. The heterophilic interaction with SCARF1, which is stronger than the homophilic interaction with itself, is suppressed by the presence of SCARF1 ligand such as Ac-LDL (By similarity).

    Alternative splice isoforms for SCARF2 Gene


neXtProt entry for SCARF2 Gene

Proteomics data for SCARF2 Gene at MOPED

Post-translational modifications for SCARF2 Gene

  • Glycosylation at Asn 83, Asn 310, Asn 365, and Asn 403
  • Modification sites at PhosphoSitePlus

Other Protein References for SCARF2 Gene

Antibody Products

  • R&D Systems Antibodies for SCARF2 (SREC-II/SCARF2)

No data available for DME Specific Peptides for SCARF2 Gene

Domains & Families for SCARF2 Gene

Suggested Antigen Peptide Sequences for SCARF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 EGF-like domains.
  • Contains 7 EGF-like domains.
genes like me logo Genes that share domains with SCARF2: view

No data available for Gene Families for SCARF2 Gene

Function for SCARF2 Gene

Molecular function for SCARF2 Gene

UniProtKB/Swiss-Prot Function:
Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity).

Gene Ontology (GO) - Molecular Function for SCARF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity --
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with SCARF2: view
genes like me logo Genes that share phenotypes with SCARF2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SCARF2 Gene

Localization for SCARF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARF2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SCARF2 Gene COMPARTMENTS Subcellular localization image for SCARF2 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SCARF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IDA 21423176
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCARF2: view

Pathways & Interactions for SCARF2 Gene

SuperPathways for SCARF2 Gene

No Data Available

Interacting Proteins for SCARF2 Gene

Gene Ontology (GO) - Biological Process for SCARF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis --
GO:0007155 cell adhesion IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules --
genes like me logo Genes that share ontologies with SCARF2: view

No data available for Pathways by source and SIGNOR curated interactions for SCARF2 Gene

Drugs & Compounds for SCARF2 Gene

No Compound Related Data Available

Transcripts for SCARF2 Gene

mRNA/cDNA for SCARF2 Gene

Unigene Clusters for SCARF2 Gene

Scavenger receptor class F, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCARF2 Gene

No ASD Table

Relevant External Links for SCARF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCARF2 Gene

mRNA expression in normal human tissues for SCARF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCARF2 Gene

This gene is overexpressed in Artery - Aorta (x4.3).

Protein differential expression in normal tissues from HIPED for SCARF2 Gene

This gene is overexpressed in Heart (35.6), Platelet (14.1), and Monocytes (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCARF2 Gene

SOURCE GeneReport for Unigene cluster for SCARF2 Gene Hs.474251

mRNA Expression by UniProt/SwissProt for SCARF2 Gene

Tissue specificity: Predominantly expressed in endothelial cells. Expressed in heart, placenta, lung, kidney, spleen, small intestine and ovary.
genes like me logo Genes that share expression patterns with SCARF2: view

Protein tissue co-expression partners for SCARF2 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for SCARF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCARF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCARF2 35
  • 87.37 (n)
  • 89.45 (a)
  • 89 (a)
(Canis familiaris)
Mammalia SCARF2 35
  • 83.61 (n)
  • 83.47 (a)
  • 93 (a)
(Mus musculus)
Mammalia Scarf2 35
  • 83.45 (n)
  • 85.84 (a)
Scarf2 16
Scarf2 36
  • 86 (a)
(Pan troglodytes)
Mammalia SCARF2 35
  • 97.78 (n)
  • 96.73 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Scarf2 35
  • 83.84 (n)
  • 86.58 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 19 (a)
(Ornithorhynchus anatinus)
Mammalia SCARF2 36
  • 72 (a)
(Gallus gallus)
Aves SCARF2 35
  • 68.44 (n)
  • 66.25 (a)
  • 55 (a)
(Anolis carolinensis)
Reptilia SCARF2 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485666 35
  • 56.76 (n)
  • 58.83 (a)
(Danio rerio)
Actinopterygii LOC100329632 35
  • 56.03 (n)
  • 52.19 (a)
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta nimA 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for SCARF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCARF2 Gene

Gene Tree for SCARF2 (if available)
Gene Tree for SCARF2 (if available)

Paralogs for SCARF2 Gene

Paralogs for SCARF2 Gene

(1) SIMAP similar genes for SCARF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCARF2: view

Variants for SCARF2 Gene

Sequence variations from dbSNP and Humsavar for SCARF2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs361566 - 20,431,352(+) GCCGG(A/G)CTCAC reference, missense
rs361739 -- 20,431,377(+) CTCCG(C/G)GGGTG synonymous-codon, reference
rs759609 -- 20,425,810(-) CCGCG(C/G)CCCCC synonymous-codon, reference
rs759610 -- 20,425,804(-) CCCCC(A/C/G)GGGCT synonymous-codon, reference
rs759611 - 20,425,657(-) GCTGA(C/G)GTGCG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for SCARF2 Gene

Variant ID Type Subtype PubMed ID
nsv518950 CNV Gain 19592680
nsv436867 CNV Insertion 17901297
nsv436864 CNV Insertion 17901297
nsv828954 CNV Gain 20364138
nsv914390 CNV Gain 21882294
dgv4867n71 CNV Gain 21882294
nsv914393 CNV Gain 21882294
nsv834135 CNV Gain 17160897
nsv519901 CNV Gain 19592680
nsv834136 CNV Loss 17160897
dgv4868n71 CNV Loss 21882294
nsv509809 CNV Insertion 20534489
nsv523162 CNV Loss 19592680
nsv834138 CNV Loss 17160897
nsv914400 CNV Loss 21882294
nsv914401 CNV Loss 21882294
nsv828955 CNV Gain 20364138

Variation tolerance for SCARF2 Gene

Gene Damage Index Score: 12.49; 94.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCARF2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCARF2 Gene

Disorders for SCARF2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SCARF2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
van den ende-gupta syndrome
  • marden-walker-like syndrome
van den ende-gupta sndrome
  • blepharophimosis, arachnodactyly, and congenital contractures
eyelid disease
  • eyelid disorders
  • isolated congenital sclerocornea
- elite association


  • Van den Ende-Gupta syndrome (VDEGS) [MIM:600920]: A syndrome characterized by craniofacial and skeletal abnormalities that include blepharophimosis, a flat and wide nasal bridge, narrow and beaked nose, hypoplastic maxilla with or without cleft palate and everted lower lip, prominent ears, down-slanting eyes, arachnodactyly, and camptodactyly. Patients present congenital joint contractures that improve without intervention, and normal growth and development. Intelligence is normal. Rarely, enlarged cerebella can be present. Some patients experience respiratory problems due to laryngeal abnormalities. {ECO:0000269 PubMed:20887961}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SCARF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SCARF2: view

No data available for Genatlas for SCARF2 Gene

Publications for SCARF2 Gene

  1. SREC-II, a new member of the scavenger receptor type F family, trans- interacts with SREC-I through its extracellular domain. (PMID: 12154095) Ishii J. … Arai H. (J. Biol. Chem. 2002) 2 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. Sclerocornea in a patient with van den Ende-Gupta syndrome homozygous for a SCARF2 microdeletion. (PMID: 24478002) Migliavacca M.P. … Perez A.B. (Am. J. Med. Genet. A 2014) 67
  4. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for I^-Pix in negative regulation of focal adhesion maturation. (PMID: 21423176) Kuo J.C. … Waterman C.M. (Nat. Cell Biol. 2011) 67
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67

Products for SCARF2 Gene

Sources for SCARF2 Gene

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