Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SCARF1 Gene

Aliases for SCARF1 Gene

  • Scavenger Receptor Class F, Member 1 2 3
  • Acetyl LDL Receptor 2 3 4
  • Scavenger Receptor Expressed By Endothelial Cells 1 3 4
  • SREC-I 3 4
  • SREC 3 4
  • Scavenger Receptor Expressed By Endothelial Cells 2
  • KIAA0149 4
  • SREC1 3

External Ids for SCARF1 Gene

Previous GeneCards Identifiers for SCARF1 Gene

  • GC17P001630
  • GC17M001872
  • GC17M001487
  • GC17M001743
  • GC17M001484
  • GC17M001485
  • GC17M001537
  • GC17M001436

Summaries for SCARF1 Gene

Entrez Gene Summary for SCARF1 Gene

  • The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

GeneCards Summary for SCARF1 Gene

SCARF1 (Scavenger Receptor Class F, Member 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include transmembrane signaling receptor activity and low-density lipoprotein particle binding. An important paralog of this gene is MEGF11.

UniProtKB/Swiss-Prot for SCARF1 Gene

  • Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARF1 Gene

Genomics for SCARF1 Gene

Regulatory Elements for SCARF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCARF1 Gene

Chromosome:
17
Start:
1,633,858 bp from pter
End:
1,645,789 bp from pter
Size:
11,932 bases
Orientation:
Minus strand

Genomic View for SCARF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCARF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARF1 Gene

Proteins for SCARF1 Gene

  • Protein details for SCARF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14162-SREC_HUMAN
    Recommended name:
    Scavenger receptor class F member 1
    Protein Accession:
    Q14162
    Secondary Accessions:
    • A8MQ05
    • O43701
    • Q8NHD2
    • Q8NHD3
    • Q8NHD4
    • Q8NHD5

    Protein attributes for SCARF1 Gene

    Size:
    830 amino acids
    Molecular mass:
    87387 Da
    Quaternary structure:
    • Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL (By similarity).

    Alternative splice isoforms for SCARF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCARF1 Gene

Proteomics data for SCARF1 Gene at MOPED

Post-translational modifications for SCARF1 Gene

  • Glycosylation at Asn 289, Asn 382, and Asn 393
  • Modification sites at PhosphoSitePlus

Other Protein References for SCARF1 Gene

Antibody Products

  • R&D Systems Antibodies for SCARF1 (SREC-I/SCARF1)

No data available for DME Specific Peptides for SCARF1 Gene

Domains & Families for SCARF1 Gene

Protein Domains for SCARF1 Gene

Suggested Antigen Peptide Sequences for SCARF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14162

UniProtKB/Swiss-Prot:

SREC_HUMAN :
  • Contains 6 EGF-like domains.
Domain:
  • Contains 6 EGF-like domains.
genes like me logo Genes that share domains with SCARF1: view

No data available for Gene Families for SCARF1 Gene

Function for SCARF1 Gene

Molecular function for SCARF1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).

Gene Ontology (GO) - Molecular Function for SCARF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9395444
GO:0005044 scavenger receptor activity IDA 9395444
GO:0005515 protein binding --
GO:0030169 low-density lipoprotein particle binding IDA 9395444
genes like me logo Genes that share ontologies with SCARF1: view

Phenotypes for SCARF1 Gene

genes like me logo Genes that share phenotypes with SCARF1: view

Animal Models for SCARF1 Gene

MGI Knock Outs for SCARF1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SCARF1 Gene

Localization for SCARF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARF1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCARF1 Gene COMPARTMENTS Subcellular localization image for SCARF1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SCARF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IDA 9395444
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with SCARF1: view

Pathways & Interactions for SCARF1 Gene

genes like me logo Genes that share pathways with SCARF1: view

Pathways by source for SCARF1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SCARF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006707 cholesterol catabolic process IC 9395444
GO:0006898 receptor-mediated endocytosis TAS 9395444
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 9395444
GO:0010976 positive regulation of neuron projection development ISS --
genes like me logo Genes that share ontologies with SCARF1: view

No data available for SIGNOR curated interactions for SCARF1 Gene

Drugs & Compounds for SCARF1 Gene

(1) Drugs for SCARF1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fucoidan Pharma 2

(1) Additional Compounds for SCARF1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LIPID
genes like me logo Genes that share compounds with SCARF1: view

Transcripts for SCARF1 Gene

Unigene Clusters for SCARF1 Gene

Scavenger receptor class F, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCARF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCARF1 Gene

No ASD Table

Relevant External Links for SCARF1 Gene

GeneLoc Exon Structure for
SCARF1
ECgene alternative splicing isoforms for
SCARF1

Expression for SCARF1 Gene

mRNA expression in normal human tissues for SCARF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCARF1 Gene

This gene is overexpressed in Spleen (x4.9).

Protein differential expression in normal tissues from HIPED for SCARF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.3), Heart (24.7), and Platelet (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCARF1 Gene



SOURCE GeneReport for Unigene cluster for SCARF1 Gene Hs.647430

mRNA Expression by UniProt/SwissProt for SCARF1 Gene

Q14162-SREC_HUMAN
Tissue specificity: Endothelial cells
genes like me logo Genes that share expression patterns with SCARF1: view

Protein tissue co-expression partners for SCARF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SCARF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCARF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCARF1 35
  • 83.84 (n)
  • 78.29 (a)
SCARF1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCARF1 35
  • 84.41 (n)
  • 78.21 (a)
SCARF1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scarf1 35
  • 78.08 (n)
  • 72.73 (a)
Scarf1 16
Scarf1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCARF1 35
  • 91.74 (n)
  • 87.73 (a)
SCARF1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scarf1 35
  • 77.82 (n)
  • 72.26 (a)
oppossum
(Monodelphis domestica)
Mammalia SCARF1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCARF1 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCARF1 35
  • 62.28 (n)
  • 55.24 (a)
SCARF1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCARF1 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scarf1 35
  • 56.02 (n)
  • 52.21 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100005273 35
  • 54.28 (n)
  • 48.27 (a)
scarf1 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nimA 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for SCARF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCARF1 Gene

ENSEMBL:
Gene Tree for SCARF1 (if available)
TreeFam:
Gene Tree for SCARF1 (if available)

Paralogs for SCARF1 Gene

Paralogs for SCARF1 Gene

(2) SIMAP similar genes for SCARF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SCARF1: view

Variants for SCARF1 Gene

Sequence variations from dbSNP and Humsavar for SCARF1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs148176299 untested 1,635,522(+) GCGCG(A/G)GATGG reference, missense, synonymous-codon, nc-transcript-variant
VAR_047249 -
VAR_047250 -
VAR_047251 -
VAR_047252 -

Structural Variations from Database of Genomic Variants (DGV) for SCARF1 Gene

Variant ID Type Subtype PubMed ID
nsv907502 CNV Loss 21882294
nsv457635 CNV Gain 19166990
nsv907511 CNV Loss 21882294
dgv3031n71 CNV Loss 21882294
nsv907513 CNV Loss 21882294
nsv527897 CNV Loss 19592680
nsv907515 CNV Loss 21882294
dgv3032n71 CNV Loss 21882294
nsv516055 CNV Gain+Loss 19592680
nsv907517 CNV Loss 21882294
nsv827855 CNV Loss 20364138

Variation tolerance for SCARF1 Gene

Residual Variation Intolerance Score: 97.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.83; 83.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCARF1 Gene

HapMap Linkage Disequilibrium report
SCARF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCARF1 Gene

Disorders for SCARF1 Gene

Relevant External Links for SCARF1

Genetic Association Database (GAD)
SCARF1
Human Genome Epidemiology (HuGE) Navigator
SCARF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCARF1
genes like me logo Genes that share disorders with SCARF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCARF1 Gene

Publications for SCARF1 Gene

  1. Human peritoneal monocytic cells: lipoprotein uptake and foam cell formation. (PMID: 9464462) Winzerling J.J. … McNamara D.J. (Life Sci. 1998) 23 67
  2. Identification of a subpopulation of human renal microvascular endothelial cells with capacity to form capillary-like cord and tube structures. (PMID: 9156341) Martin M. … Daniel T.O. (In Vitro Cell. Dev. Biol. Anim. 1997) 23 67
  3. Expression cloning of a novel scavenger receptor from human endothelial cells. (PMID: 9395444) Adachi H. … Inoue K. (J. Biol. Chem. 1997) 2 67
  4. Purification of the human THP-1 monocyte-macrophage triglyceride-rich lipoprotein receptor. (PMID: 7755626) Ramprasad M.P. … Bradley W.A. (Biochem. Biophys. Res. Commun. 1995) 23 67
  5. Mechanisms of cytoadhesion of flowing, parasitized red blood cells from Gambian children with falciparum malaria. (PMID: 7542844) Cooke B.M. … Nash G.B. (Am. J. Trop. Med. Hyg. 1995) 23 67

Products for SCARF1 Gene

Sources for SCARF1 Gene

Back to Top

Content