Aliases for SCARB2 Gene
- Scavenger Receptor Class B Member 2 2 3 4 5
- CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 2 (Lysosomal Integral Membrane Protein II) 2 3
- 85 KDa Lysosomal Membrane Sialoglycoprotein 3 4
- Scavenger Receptor Class B, Member 2 2 3
- Lysosome Membrane Protein II 3 4
- CD36 Antigen-Like 2 3 4
- LIMP II 3 4
- CD36L2 3 4
- LIMPII 3 4
- LGP85 3 4
External Ids for SCARB2 Gene
Previous HGNC Symbols for SCARB2 Gene
Previous GeneCards Identifiers for SCARB2 Gene
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
GeneCards Summary for SCARB2 Gene
SCARB2 (Scavenger Receptor Class B Member 2) is a Protein Coding gene. Diseases associated with SCARB2 include epilepsy, progressive myoclonic 4, with or without renal failure and unverricht-lundborg syndrome. Among its related pathways are Lysosome. GO annotations related to this gene include enzyme binding and receptor activity. An important paralog of this gene is CD36.
UniProtKB/Swiss-Prot for SCARB2 Gene
Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.
(Microbial infection) Acts as a receptor for enterovirus 71.