SCARB1 Gene
protein-coding GIFtS : 64
GCID: GC12 M125262
scavenger receptor class B, member 1 (Previous names: CD36 antigen (collagen type I receptor, thrombospondin... ) (Previous symbol: CD36L1 )
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Aliasesfor SCARB1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Scavenger Receptor Class B, Member 1 1 2 CD36 And LIMPII Analogous 12 3 CD36L11 2 3 5 HDLQTL62 5 CLA11 2 3 5 Scavenger Receptor Class B Member 12 CLA-11 2 3 Scavenger Receptor Class B Type III2 SR-BI1 2 3 CD36 Antigen3 SRB11 2 3 CD36 Antigen-Like 13 CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 11 2 Collagen Type I Receptor, Thrombospondin Receptor-Like 13
Export aliases for SCARB1 gene to outside databases Previous GC identifers: GC12M123982 GC12M125008 GC12M123615 GC12M123787 GC12M122224
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Summariesfor SCARB1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SCARB1 : The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Mar 2011) UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0 Function : Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine andapoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity) Gene Wiki entry for SCARB1
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Genomic Viewsfor SCARB1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009755.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SCARB1 gene promoter: AP-1 ATF-2 CREB PPAR-gamma1 SREBP-1a deltaCREB PPAR-gamma2 c-Jun NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for SCARB1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCARB1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.32 SCARB1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M125262: view genomic region
(about GC identifiers )
Start:
125,261,606 bp from pter
End:
125,367,214 bp from pter
Size:
105,609 bases
Orientation:
minus strand
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Proteinsfor SCARB1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0 (See
protein sequence )Recommended Name: Scavenger receptor class B member 1 Size : 552 amino acids; 60878 Da
Subunit : Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteinsheterodimer. The C-terminal region binds to PDZK1 (By similarity)
Subcellular location : Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein.Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae
Secondary accessions : Q14016 Q52LZ5 Q6KFX4Alternative splicing : 4 isoforms : Q8WTV0-1 Q8WTV0-2 Q8WTV0-3 Q8WTV0-4 (May be due to a competing donor splice site. No experimental confirmation available)Explore the universe of human proteins at neXtProt for SCARB1: NX_Q8WTV0 Post-translational modifications:
N-glycosylated1
The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8WTV0 SCARB1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001076428.1 NP_005496.4 ENSEMBL proteins: ENSP00000343795 ENSP00000414979 ENSP00000261693 ENSP00000442862 ENSP00000444851 ENSP00000443454 ENSP00000365984 ENSP00000443286 ENSP00000446107 Reactome Protein details: Q8WTV0 Human Recombinant Protein Products: Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8 ): About this table
SCARB1 for ontologies About GeneDecksing SCARB1 Antibody Products: Assay Products for SCARB1:
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Protein
Domains / Familiesfor SCARB1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SCARB1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8WTV0 ProtoNet protein and cluster: Q8WTV0
1 Blocks protein family : IPB002159 Adhesion molecule CD36 family signature UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0 Similarity : Belongs to the CD36 family
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Functionfor SCARB1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0 Function : Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine andapoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SCARB1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SCARB1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SCARB1 (NM_001082959 ) Sino Biological Human cDNA Clone for SCARB1 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCARB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SCARB1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCARB1
Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12 ): About this table
SCARB1 for ontologies About GeneDecksing Animal Models: Mouse knock-outs for SCARB1: Scarb1 tm1Dhu Scarb1 tm1Kri Scarb1 tm1.1Thh 9 MGI mutant phenotypes (inferred from 8 alleles ) (MGI details for Scarb1) :
SCARB1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor SCARB1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/12 super-pathways (see all 12 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Lipoprotein metabolism 2 Metabolism 3 Statin Pathway, Pharmacodynamics 4 Folate Metabolism 5 Selenium Pathway
Pathway sources See GeneCards unified pathways Show all pathways 5 BioSystems Pathways for SCARB1 5
Reactome Pathways for SCARB1 1 PharmGKB Pathway for SCARB1 5
Kegg Pathways (Kegg details for SCARB1) :
SCARB1 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCARB1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/15 Interacting proteins for SCARB1 (Q8WTV0 1 , 3 ENSP00000261693 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 15 )About this table Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34 ): About this table
SCARB1 for ontologies About GeneDecksing
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Drugs & Compoundsfor SCARB1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
SCARB1 for compounds About GeneDecksing Browse Tocris compounds for SCARB1 10/155 HMDB Compounds for SCARB1 (see all 155 ) About this table 1 DrugBank Compound for SCARB1 About this table 10/58 Novoseek chemical compound relationships for SCARB1 gene (see all 58 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
cholesterol
83.5
510
10625497 (7), 14617739 (7), 16185081 (7), 17105723 (6) (see all 99 )
cholesterol ester
70.2
29
15064092 (6), 10337864 (2), 19179658 (2), 18270459 (1) (see all 8 )
lipid
64.8
127
11564739 (4), 20085651 (4), 10625497 (3), 12235173 (3) (see all 69 )
sterol
58.3
27
14967816 (7), 11893773 (5), 15486308 (2), 16162942 (1) (see all 11 )
phospholipid
55.6
29
9488688 (4), 14594995 (2), 10938082 (2), 12671027 (2) (see all 18 )
probucol
53.6
13
16151015 (5), 20075420 (1), 16410457 (1), 10638221 (1) (see all 5 )
mcla
51.5
1
14973113 (1)
fenofibrate
50
16
15837786 (5), 16530456 (1), 12453904 (1), 17533223 (1)
lutein
46.3
9
15554873 (3), 15771974 (1), 18641187 (1)
phosphatidylcholine
43.4
8
7541795 (1), 10880355 (1), 10764676 (1), 11564739 (1) (see all 6 )
Search CenterWatch for drugs/clinical trials and news about SCARB1 / SCRB1
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Transcriptsfor SCARB1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SCARB1 gene (2 alternative transcripts): NM_001082959.1 NM_005505.4 Unigene Cluster for SCARB1:
Scavenger receptor class B, member 1 Hs.731377 [show with all ESTs ] Unigene Representative Sequence: AB209436 14 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000339570 (uc001ugn.4 ) ENST00000415380 (uc001ugo.4 ) ENST00000261693 (uc001ugm.4 uc010tbd.2 )ENST00000545305 ENST00000538291 (uc001ugp.3 ) ENST00000546215 ENST00000535005 ENST00000544327 ENST00000545493 ENST00000541661 ENST00000539320 ENST00000376788 ENST00000540495 ENST00000541205 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SCARB1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SCARB1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SCARB1 (NM_001082959 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCARB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SCARB1
Additional cDNA sequence: AB209436.1 AF254409.1 AF515445.1 AK124112.1 AK302779.1 AK304730.1 BC034322.1 BC080647.1 BC093732.1 BC112037.1 BC143319.1 Z22555.1
24/37 DOTS entries (see all 37 ): DT.100882046 DT.100882059
DT.318393 DT.97849883 DT.95319154 DT.100882044 DT.100645767 DT.102834463 DT.101983995 DT.424994 DT.100733623 DT.121203134 DT.100843852 DT.100763417 DT.100882058 DT.100882063 DT.95262103 DT.97849880 DT.100882053 DT.100882023 DT.121202819 DT.121202863 DT.100799627 DT.100882041 24/54 AceView cDNA sequences (see all 54 ):
AA341604 AI160219 CA394938 AW050932 BQ877329 BG741048 BI915510 BP350733 CR616190 BQ431992 AI744069 AI383019 AI636316 BI829800 AA764923 BE275786 CB266465 CR600982 CR599999 AI371524 AW664449 AW006991 BG760684 BX090902 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SCARB1 (see all 8 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 SP1 :       -   -   -                             -   -   -   -       SP2 :                                                   SP3 :       -   -   -                                         SP4 :                                       -   -   -   -   -     SP5 :           -                                        
ECgene alternative splicing isoforms for SCARB1
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Expression for SCARB1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SCARB1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAGGACGGGC
About this image SCARB1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor Z1 (Embryonic Progenitor Cell)Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See SCARB1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SCARB1 SOURCE GeneReport for Unigene cluster: Hs.731377 UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0 Tissue specificity : Widely expressed SABiosciences Custom PCR Arrays for SCARB1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SCARB1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SCARB1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SCARB1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SCARB1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCARB1
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Orthologsfor SCARB1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for SCARB1 gene from 5/22 species (see all 22 ) About this table
ENSEMBL Gene Tree for SCARB1 (if available)TreeFam Gene Tree for SCARB1 (if available)
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Paralogsfor SCARB1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SCARB1 gene SCARB2 2 CD36 2 2 SIMAP similar genes for SCARB1 using alignment to 7 protein entries: SCRB1_HUMAN (see all proteins ):SCARB2 CD36
SCARB1 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for SCARB1 PGOHUM00000241458
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Genomic Variantsfor SCARB1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0 Polymorphism : Genetic variations in SCARB1 define the high density lipoprotein cholesterol level quantitative traitlocus 6 (HDLCQ16) [MIM:610762]
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SCARB1 (125261606 - 125367214 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for SCARB1 1 CNV : 5700 1 Indel : 44982 Human Gene Mutation Database (HGMD) : SCARB1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SCARB1
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Disorders
/ Diseasesfor SCARB1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SCARB1 for disorders About GeneDecksing OMIM gene information: 601040 OMIM disorders : 610762 20/56 diseases for SCARB1 (see all 56 ): About MalaCards high density lipoprotien cholesterol level qtl6 neutrophil-specific granule deficiency specific granule deficiency platelet glycoprotein iv deficiency hepatitis c glycogen storage disease type ia cholesterol glycogen storage disease age related macular degeneration cetp deficiency hepatitis leydig cell tumor hyperalphalipoproteinemia type 2 diabetes mellitus coronary heart disease macular degeneration primary biliary cirrhosis addison's disease insulin resistance myocardial infarction 3 diseases from the University of Copenhagen DISEASES database for SCARB1 :Atherosclerosis Malaria Diabetes mellitus 10/30 Novoseek disease relationships for SCARB1 gene (see all 30 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
cetp deficiency
70.5
1
15064092 (1)
atherosclerosis
70.4
49
17272756 (5), 16122381 (4), 16133421 (3), 20137092 (3) (see all 29 )
hyperalphalipoproteinemia
69.1
1
19158204 (1)
hepatitis c
45.3
9
19828610 (1), 15998599 (1), 19087225 (1), 19094442 (1) (see all 8 )
atherosclerotic plaque
44.2
8
16122381 (2), 15970294 (1), 20137092 (1), 12615688 (1) (see all 7 )
leydig cell tumor
35.4
1
9253328 (1)
cardiovascular diseases
26.3
4
19837407 (1), 20064494 (1), 19718657 (1)
dyslipidemia
26.2
2
17700364 (1), 16501936 (1)
coronary artery disease
25.8
7
11861414 (1), 12227853 (1), 17618962 (1), 16542392 (1) (see all 6 )
carcinoma adrenocortical
24.7
3
12668173 (1), 10215860 (1), 9253328 (1)
Genetic Association Database (GAD): SCARB1 Human Genome Epidemiology (HuGE) Navigator: SCARB1 (57 documents) Export disorders for SCARB1 gene to outside databases
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Publicationsfor SCARB1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SCARB1 gene, integrated from 9 sources (see all 512 ): (articles sorted by number of sources associating them with SCARB1) Utopia : connect your pdf to the dynamic world of online information
Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. (PubMed id 7689561) 1 , 2 , 3, 9 Calvo D. and Vega M. (1993) Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia. (PubMed id 12519372) 1 , 2 , 4 Tai E.S.... Carmena R. (2003) Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study. (PubMed id 15910850) 1 , 4, 9 Richard E....McCarthy J.J. (2005) Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study. (PubMed id 12788901) 1 , 4, 9 Osgood D....Ordovas J.M. (2003) Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations. (PubMed id 15681296) 1 , 4, 9 Rodriguez-Esparragon F....Ferrario C.M. (2005) Population-based study of SR-BI genetic variation and lipid profile. (PubMed id 15186961) 1 , 4, 9 Morabia A....Gilliam T.C. (2004) Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. (PubMed id 12913001) 1 , 2 , 9 Bartosch B.... Cosset F.-L. (2003) Association between HaeIII polymorphism of scavenger receptor class B type I gene and plasma HDL-cholesterol concentration. (PubMed id 12227853) 1 , 4, 9 Hong S.H....Kim J.Q. (2002) Relationship of genetic variation in genes encoding apolipoprotein A-IV, scavenger receptor BI, HMG-CoA reductase, CETP and apolipoprotein E with cholesterol metabolism and the response to plant stanol ester consumption. (PubMed id 11952809) 1 , 4, 9 Plat J. and Mensink R.P. (2002) Molecular genetic analysis of familial hypercholesterolemia: spectrum and regional difference of LDL receptor gene mutations in Japanese population. (PubMed id 12417285) 1 , 4, 9 Yu W....Mabuchi H. (2002)
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External Searches for SCARB1 gene
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Genome Databases showing SCARB1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Specialized Databases showing SCARB1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SCARB1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SCARB1 gene: Search GeneIP for patents involving SCARB1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SCARB1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for SCARB1 OriGene shRNA RFP for SCARB1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SCARB1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SCARB1 OriGene Protein Over-expression Lysate for SCARB1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SCARB1 OriGene 3'-UTR Clone for SCARB1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SCARB1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SCARB1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SCARB1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SCARB1 OriGene Custom Protein Services for SCARB1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCARB1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SCARB1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCARB1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SCARB1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SCARB1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SCARB1
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SCARB1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCARB1
ThermoFisher Antibody for SCARB1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SCARB1
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