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Aliases for SCARB1 Gene

Aliases for SCARB1 Gene

  • Scavenger Receptor Class B Member 1 2 3 5
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 1 2 3
  • CD36 And LIMPII Analogous 1 3 4
  • CD36L1 3 4
  • CLA-1 3 4
  • SR-BI 3 4
  • CLA1 3 4
  • SRB1 3 4
  • Collagen Type I Receptor, Thrombospondin Receptor-Like 1 4
  • Scavenger Receptor Class B, Member 1 2
  • Scavenger Receptor Class B Type III 3
  • CD36 Antigen-Like 1 4
  • CD36 Antigen 4
  • HDLQTL6 3

External Ids for SCARB1 Gene

Previous HGNC Symbols for SCARB1 Gene

  • CD36L1

Previous GeneCards Identifiers for SCARB1 Gene

  • GC12M123982
  • GC12M125008
  • GC12M123615
  • GC12M123787
  • GC12M125262
  • GC12M122224

Summaries for SCARB1 Gene

Entrez Gene Summary for SCARB1 Gene

  • The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for SCARB1 Gene

SCARB1 (Scavenger Receptor Class B Member 1) is a Protein Coding gene. Diseases associated with SCARB1 include Hepatitis C and Hepatitis. Among its related pathways are Statin Pathway and Vitamin digestion and absorption. GO annotations related to this gene include protein homodimerization activity and phosphatidylserine binding. An important paralog of this gene is SCARB2.

UniProtKB/Swiss-Prot for SCARB1 Gene

  • Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high density lipoproteins (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Necessary for selective HDL-cholesterol uptake (PubMed:26965621). Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).

  • (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694).

Gene Wiki entry for SCARB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARB1 Gene

Genomics for SCARB1 Gene

Regulatory Elements for SCARB1 Gene

Enhancers for SCARB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F124850 1.2 Ensembl ENCODE 20.5 +28.7 28685 6.6 MLX ARID4B DMAP1 ZNF48 YY1 FOS ZNF263 SP5 NFYC MXD4 SCARB1 DHX37 UBC RFLNA LOC105370050 GC12P124823
GH12F124832 0.6 Ensembl ENCODE 15.3 +44.3 44267 11.0 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 DEK ZNF263 SCARB1 GC12P124823 LOC105370050
GH12F124913 0.7 FANTOM5 ENCODE 11.5 -36.5 -36515 12.7 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 DHX37 NCOR2 LOC100131779 ENSG00000256814 ENSG00000270130 ENSG00000269938 ENSG00000270061 ENSG00000269997 SCARB1 BRI3BP
GH12F124793 0.2 ENCODE 11.4 +89.6 89571 0.1 ZFHX2 SCARB1 PIR47298 GC12P124823
GH12F124846 1 Ensembl ENCODE 6.8 +35.1 35077 1.6 CTCF MAZ SP3 ZMYM3 ZNF384 REST ZBTB7A ZFHX2 GLIS1 PATZ1 SCARB1 LOC105370050 GC12P124823
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SCARB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCARB1 Gene

Chromosome:
12
Start:
124,776,856 bp from pter
End:
124,882,668 bp from pter
Size:
105,813 bases
Orientation:
Minus strand

Genomic View for SCARB1 Gene

Genes around SCARB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCARB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCARB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARB1 Gene

Proteins for SCARB1 Gene

  • Protein details for SCARB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTV0-SCRB1_HUMAN
    Recommended name:
    Scavenger receptor class B member 1
    Protein Accession:
    Q8WTV0
    Secondary Accessions:
    • F8W8N0
    • Q14016
    • Q52LZ5
    • Q6KFX4

    Protein attributes for SCARB1 Gene

    Size:
    552 amino acids
    Molecular mass:
    60878 Da
    Quaternary structure:
    • The C-terminal region binds to PDZK1.
    • (Microbial infection) Interacts with hepatitis C virus E1:E2 glycoproteins.

    Alternative splice isoforms for SCARB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCARB1 Gene

Post-translational modifications for SCARB1 Gene

  • N-glycosylated.
  • The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
  • Ubiquitination at Lys 484
  • Glycosylation at Asn 102, Asn 108, Asn 173, Asn 212, Asn 227, Asn 255, Asn 310, Asn 330, and Asn 383
  • Modification sites at PhosphoSitePlus

Other Protein References for SCARB1 Gene

No data available for DME Specific Peptides for SCARB1 Gene

Domains & Families for SCARB1 Gene

Gene Families for SCARB1 Gene

Protein Domains for SCARB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WTV0

UniProtKB/Swiss-Prot:

SCRB1_HUMAN :
  • Belongs to the CD36 family.
Family:
  • Belongs to the CD36 family.
genes like me logo Genes that share domains with SCARB1: view

Function for SCARB1 Gene

Molecular function for SCARB1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high density lipoproteins (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Necessary for selective HDL-cholesterol uptake (PubMed:26965621). Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694).

Gene Ontology (GO) - Molecular Function for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 12651854
GO:0001618 virus receptor activity IEA --
GO:0001786 phosphatidylserine binding ISS --
GO:0001875 lipopolysaccharide receptor activity IDA 12651854
GO:0005215 transporter activity TAS 9211901
genes like me logo Genes that share ontologies with SCARB1: view
genes like me logo Genes that share phenotypes with SCARB1: view

Animal Models for SCARB1 Gene

MGI Knock Outs for SCARB1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SCARB1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCARB1 Gene

Localization for SCARB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARB1 Gene

Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCARB1 Gene COMPARTMENTS Subcellular localization image for SCARB1 gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
endoplasmic reticulum 2
peroxisome 2
cytosol 1
endosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0005901 caveola TAS 12651854
genes like me logo Genes that share ontologies with SCARB1: view

Pathways & Interactions for SCARB1 Gene

genes like me logo Genes that share pathways with SCARB1: view

Gene Ontology (GO) - Biological Process for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001935 endothelial cell proliferation IEA --
GO:0006702 androgen biosynthetic process IEA --
GO:0006707 cholesterol catabolic process IEA --
GO:0006869 lipid transport IEA --
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with SCARB1: view

No data available for SIGNOR curated interactions for SCARB1 Gene

Drugs & Compounds for SCARB1 Gene

(40) Drugs for SCARB1 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Fenofibrate Approved Pharma 169
Phosphatidyl serine Approved Nutra Target 0
Peginterferon alfa-2a Approved, Investigational Pharma 563
Ribavirin Approved Pharma 984

(176) Additional Compounds for SCARB1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CE(10:0)
  • 3b-(Decanoyloxy)-5-cholestene
  • 5-Cholesten-3b-ol caprate
  • Cholest-5-en-3b-ol caprate
  • Cholesterol 3-decanoate
  • Cholesterol 3-decanoic acid
1183-04-6
CE(12:0)
  • (3beta)-Cholest-5-en-3-ol dodecanoate
  • (3beta)-Cholest-5-en-3-ol dodecanoic acid
  • 12:0 Cholesterol ester
  • Cholest-5-en-3-beta-yl laurate
  • Cholest-5-en-3-yl laurate
1908-11-8
CE(14:0)
  • 1-Myristoyl-cholesterol
  • 14:0 Cholesterol ester
  • CE(14:0)
  • CE(14:0/0:0)
  • Cholest-5-en-3-ol (3beta)-tetradecanoate
1989-52-2
CE(14:1(9Z))
  • 1-Myristoleoyl-cholesterol
  • 14:1(9Z) Cholesterol ester
  • CE(14:1)
  • CE(14:1/0:0)
  • CE(14:1n5/0:0)
CE(16:0)
  • 1-Palmitoyl-cholesterol
  • 16:0 Cholesterol ester
  • Cholest-5-en-3-yl palmitate
  • Cholest-5-ene-3-beta-yl palmitate
  • Cholesterol 1-hexadecanoate
601-34-3
genes like me logo Genes that share compounds with SCARB1: view

Transcripts for SCARB1 Gene

Unigene Clusters for SCARB1 Gene

Scavenger receptor class B, member 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCARB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16
SP1: - - - - - - -
SP2:
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8:

Relevant External Links for SCARB1 Gene

GeneLoc Exon Structure for
SCARB1
ECgene alternative splicing isoforms for
SCARB1

Expression for SCARB1 Gene

mRNA expression in normal human tissues for SCARB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCARB1 Gene

This gene is overexpressed in Adrenal Gland (x20.9) and Liver (x6.3).

Protein differential expression in normal tissues from HIPED for SCARB1 Gene

This gene is overexpressed in Adrenal (49.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCARB1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SCARB1 Gene:

SCARB1

SOURCE GeneReport for Unigene cluster for SCARB1 Gene:

Hs.731377

mRNA Expression by UniProt/SwissProt for SCARB1 Gene:

Q8WTV0-SCRB1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SCARB1: view

Primer Products

No data available for Protein tissue co-expression partners for SCARB1 Gene

Orthologs for SCARB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCARB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCARB1 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia SCARB1 34 35
  • 85.14 (n)
cow
(Bos Taurus)
Mammalia SCARB1 34 35
  • 85 (n)
mouse
(Mus musculus)
Mammalia Scarb1 34 16 35
  • 80.29 (n)
rat
(Rattus norvegicus)
Mammalia Scarb1 34
  • 79.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SCARB1 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCARB1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCARB1 34 35
  • 68.4 (n)
lizard
(Anolis carolinensis)
Reptilia SCARB1 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scarb1 34
  • 62.42 (n)
zebrafish
(Danio rerio)
Actinopterygii scarb1 34 35
  • 63.5 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3433 34
fruit fly
(Drosophila melanogaster)
Insecta crq 34 35
  • 46.81 (n)
emp 35
  • 27 (a)
OneToMany
CG31741 35
  • 24 (a)
OneToMany
ninaD 35
  • 24 (a)
OneToMany
CG10345 35
  • 23 (a)
OneToMany
pes 35
  • 23 (a)
OneToMany
santa-maria 35
  • 23 (a)
OneToMany
Snmp1 35
  • 22 (a)
OneToMany
CG1887 35
  • 21 (a)
OneToMany
CG3829 35
  • 21 (a)
OneToMany
CG7227 35
  • 21 (a)
OneToMany
CG2736 35
  • 20 (a)
OneToMany
CG40006 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scav-3 35
  • 23 (a)
OneToMany
scav-5 35
  • 20 (a)
OneToMany
scav-4 35
  • 19 (a)
OneToMany
scav-6 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToOne
Species where no ortholog for SCARB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCARB1 Gene

ENSEMBL:
Gene Tree for SCARB1 (if available)
TreeFam:
Gene Tree for SCARB1 (if available)

Paralogs for SCARB1 Gene

Paralogs for SCARB1 Gene

(2) SIMAP similar genes for SCARB1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SCARB1 Gene

genes like me logo Genes that share paralogs with SCARB1: view

Variants for SCARB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SCARB1 Gene

SCRB1_HUMAN-Q8WTV0
Genetic variations in SCARB1 define the high density lipoprotein cholesterol level quantitative trait locus 6 (HDLCQ16) [MIM:610762].

Sequence variations from dbSNP and Humsavar for SCARB1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs187831231 other 124,814,309(+) CACAG(C/T)GCGGT reference, missense
rs387906791 other 124,807,881(-) GCATC(C/T)CCACC reference, missense
rs397514572 other 124,815,064(-) CGTGT(C/T)CTTCC reference, missense
rs10128951 -- 124,855,901(+) CTGGG(A/G)CCAAG intron-variant
rs1031605 -- 124,792,423(-) GTTCA(C/T)GCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCARB1 Gene

Variant ID Type Subtype PubMed ID
dgv889n106 CNV deletion 24896259
esv1953401 CNV deletion 18987734
esv2665124 CNV deletion 23128226
esv2746550 CNV deletion 23290073
esv3549941 CNV deletion 23714750
esv3631025 CNV loss 21293372
esv3631026 CNV loss 21293372
nsv1119994 CNV deletion 24896259
nsv1122780 CNV deletion 24896259
nsv52719 CNV deletion 16902084
nsv560543 CNV gain 21841781
nsv560595 CNV gain 21841781
nsv957260 CNV deletion 24416366

Variation tolerance for SCARB1 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.33; 76.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCARB1 Gene

Human Gene Mutation Database (HGMD)
SCARB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCARB1

Disorders for SCARB1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for SCARB1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis c
  • chronic hepatitis c
hepatitis
  • acute and subacute liver necrosis
hepatitis c virus
  • hepatitic c virus
hyperalphalipoproteinemia
  • cholesterol-ester transfer protein deficiency
neutrophil-specific granule deficiency
  • specific granule deficiency
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SCARB1

Genetic Association Database (GAD)
SCARB1
Human Genome Epidemiology (HuGE) Navigator
SCARB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCARB1
genes like me logo Genes that share disorders with SCARB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCARB1 Gene

Publications for SCARB1 Gene

  1. Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. (PMID: 7689561) Calvo D. … Vega M. (J. Biol. Chem. 1993) 2 3 4 22 64
  2. Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women. (PMID: 19489872) Lamon-Fava S. … Herrington D.M. (Clin. Endocrinol. (Oxf) 2010) 3 22 46 64
  3. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 4 46 64
  4. Influence of SCARB1 polymorphisms on serum lipids of hypercholesterolemic individuals treated with atorvastatin. (PMID: 20064494) Cerda A. … Hirata R.D. (Clin. Chim. Acta 2010) 3 22 46 64
  5. Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia. (PMID: 19158204) West M. … Rodriguez A. (J. Clin. Endocrinol. Metab. 2009) 3 22 46 64

Products for SCARB1 Gene

Sources for SCARB1 Gene

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