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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCARB1 Gene

protein-coding   GIFtS: 64
GCID: GC12M125262

scavenger receptor class B, member 1

(Previous names: CD36 antigen (collagen type I receptor, thrombospondin...)
(Previous symbol: CD36L1)
 Explore 56 diseases affiliated with
SCARB1 via our new
 Human Malady Compendium 
Biological research products
for SCARB1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Scavenger Receptor Class B, Member 11 2     CD36 And LIMPII Analogous 12 3
CD36L11 2 3 5     HDLQTL62 5
CLA11 2 3 5     Scavenger Receptor Class B Member 12
CLA-11 2 3     Scavenger Receptor Class B Type III2
SR-BI1 2 3     CD36 Antigen3
SRB11 2 3     CD36 Antigen-Like 13
CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 11 2     Collagen Type I Receptor, Thrombospondin Receptor-Like 13

External Ids:    HGNC: 16641   Entrez Gene: 9492   Ensembl: ENSG000000730607   OMIM: 6010405   UniProtKB: Q8WTV03   

Export aliases for SCARB1 gene to outside databases

Previous GC identifers: GC12M123982 GC12M125008 GC12M123615 GC12M123787 GC12M122224


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCARB1:
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The
encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C
virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.(provided by
RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0
Function: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and
apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae.
Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and
acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably
involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C
virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate.
Plays an important role in the uptake of HDL cholesteryl ester (By similarity)

Gene Wiki entry for SCARB1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCARB1 gene promoter:
         AP-1   ATF-2   CREB   PPAR-gamma1   SREBP-1a   deltaCREB   PPAR-gamma2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): SCARB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCARB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCARB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.32

SCARB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCARB1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M125262:  view genomic region     (about GC identifiers)

Start:
125,261,606 bp from pter      End:
125,367,214 bp from pter
Size:
105,609 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0 (See protein sequence)
Recommended Name: Scavenger receptor class B member 1  
Size: 552 amino acids; 60878 Da
Subunit: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins
heterodimer. The C-terminal region binds to PDZK1 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein.
Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called
caveolae
Secondary accessions: Q14016 Q52LZ5 Q6KFX4
Alternative splicing: 4 isoforms:  Q8WTV0-1   Q8WTV0-2   Q8WTV0-3   Q8WTV0-4   (May be due to a competing donor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCARB1: NX_Q8WTV0

Post-translational modifications:

  • N-glycosylated1
  • The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WTV0

  • SCARB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001076428.1  NP_005496.4  

    ENSEMBL proteins: 
     ENSP00000343795   ENSP00000414979   ENSP00000261693   ENSP00000442862   ENSP00000444851  
     ENSP00000443454   ENSP00000365984   ENSP00000443286   ENSP00000446107  
    Reactome Protein details: Q8WTV0
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    Uscn Proteins for SCARB1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000299integral to membrane of membrane fraction ----
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0005901caveola TAS12651854


    SCARB1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SCARB1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR005428 CD36_antigen
     IPR002159 CD36

    Graphical View of Domain Structure for InterPro Entry Q8WTV0

    ProtoNet protein and cluster: Q8WTV0

    1 Blocks protein family: IPB002159 Adhesion molecule CD36 family signature

    UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0
    Similarity: Belongs to the CD36 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0
    Function: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and
    apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae.
    Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and
    acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably
    involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C
    virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate.
    Plays an important role in the uptake of HDL cholesteryl ester (By similarity)

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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SCARB1 (see all 17):
    hsa-miR-125a-5p hsa-miR-4288 hsa-miR-632 hsa-miR-223 hsa-miR-183* hsa-miR-125b hsa-miR-761 hsa-miR-3659
    SwitchGear 3'UTR luciferase reporter plasmidSCARB1 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001530lipopolysaccharide binding IDA12651854
    GO:0001786phosphatidylserine binding ISS--
    GO:0001875lipopolysaccharide receptor activity IDA12651854
    GO:0004872receptor activity ----
    GO:0005215transporter activity TAS9211901


    SCARB1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for SCARB1: Scarb1tm1Dhu Scarb1tm1Kri Scarb1tm1.1Thh
         9 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Scarb1):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  reproductive system 

    SCARB1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lipoprotein metabolism
    Lipoprotein metabolism1.00
    Lipid digestion, mobilization, and transport0.56
    HDL-mediated lipid transport0.57
    2Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34
    3Statin Pathway, Pharmacodynamics
    Statin Pathway, Pharmacodynamics1.00
    Statin Pathway0.80
    4Folate Metabolism
    Folate Metabolism1.00
    5Selenium Pathway
    Selenium Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5 BioSystems Pathways for SCARB1 
        SREBP signalling
    Statin Pathway
    Vitamin A and carotenoid metabolism
    Selenium Pathway
    Folate Metabolism

    5        Reactome Pathways for SCARB1
        Lipid digestion, mobilization, and transport
    Metabolism
    Lipoprotein metabolism
    HDL-mediated lipid transport
    Metabolism of lipids and lipoproteins

    1 PharmGKB Pathway for SCARB1
        Statin Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for SCARB1):
        Phagosome
    Fat digestion and absorption
    Bile secretion
    Vitamin digestion and absorption
    Hepatitis C


    SCARB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCARB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/15 Interacting proteins for SCARB1 (Q8WTV01, 3 ENSP000002616934) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT2P553451, 3, ENSP000003479064EBI-78657,EBI-78458 I2D: score=2 STRING: ENSP00000347906
    APOEP026493, ENSP000002524864I2D: score=2 STRING: ENSP00000252486
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    PDZK1Q5T2W13, ENSP000003421434I2D: score=2 STRING: ENSP00000342143
    PEX5P505423, ENSP000004074014I2D: score=1 STRING: ENSP00000407401
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001935endothelial cell proliferation IEA--
    GO:0006629lipid metabolic process TAS--
    GO:0006702androgen biosynthetic process IEA--
    GO:0006707cholesterol catabolic process IEA--
    GO:0006810transport ----


    SCARB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SCARB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SCARB1

    10/155 HMDB Compounds for SCARB1 (see all 155)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CE(10:0)Decanoic acid cholesteryl ester (see all 18)1183-04-6--
    CE(12:0)cholest-5-en-3beta-yl dodecanoate (see all 19)1908-11-8--
    CE(14:0)14:0 Cholesterol ester (see all 24)1989-52-2--
    CE(14:1(9Z))CE(14:1/0:0) (see all 22)----
    CE(16:0)Cholest-5-ene-3-beta-yl palmitate (see all 23)601-34-3--
    CE(16:1(9Z))(Z)-Cholesterol 9-hexadecenoate (see all 33)16711-66-3--
    CE(18:0)cholesterol 1-octadecanoate (see all 14)----
    CE(18:1(11Z))cholesterol 1-(11Z-octadecenoate) (see all 25)----
    CE(18:1(9Z))3beta-Hydroxy-5-cholestene 3-oleate (see all 35)303-43-5--
    CE(18:2(9Z,12Z))cholesterol 1-linoleoic acid (see all 25)604-33-1--

    1 DrugBank Compound for SCARB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphatidylserine3-O-sn-Phosphatidyl-L-serine (see all 3)8002-43-5target--15541376 16371234 15791597 14594995 16530182

    10/58 Novoseek chemical compound relationships for SCARB1 gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 83.5 510 10625497 (7), 14617739 (7), 16185081 (7), 17105723 (6) (see all 99)
    cholesterol ester 70.2 29 15064092 (6), 10337864 (2), 19179658 (2), 18270459 (1) (see all 8)
    lipid 64.8 127 11564739 (4), 20085651 (4), 10625497 (3), 12235173 (3) (see all 69)
    sterol 58.3 27 14967816 (7), 11893773 (5), 15486308 (2), 16162942 (1) (see all 11)
    phospholipid 55.6 29 9488688 (4), 14594995 (2), 10938082 (2), 12671027 (2) (see all 18)
    probucol 53.6 13 16151015 (5), 20075420 (1), 16410457 (1), 10638221 (1) (see all 5)
    mcla 51.5 1 14973113 (1)
    fenofibrate 50 16 15837786 (5), 16530456 (1), 12453904 (1), 17533223 (1)
    lutein 46.3 9 15554873 (3), 15771974 (1), 18641187 (1)
    phosphatidylcholine 43.4 8 7541795 (1), 10880355 (1), 10764676 (1), 11564739 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about SCARB1 / SCRB1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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    About This Section

    REFSEQ mRNAs for SCARB1 gene (2 alternative transcripts): 
    NM_001082959.1  NM_005505.4  

    Unigene Cluster for SCARB1:

    Scavenger receptor class B, member 1
    Hs.731377  [show with all ESTs]
    Unigene Representative Sequence: AB209436
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339570(uc001ugn.4) ENST00000415380(uc001ugo.4) ENST00000261693(uc001ugm.4 uc010tbd.2)
    ENST00000545305 ENST00000538291(uc001ugp.3) ENST00000546215 ENST00000535005
    ENST00000544327 ENST00000545493 ENST00000541661 ENST00000539320 ENST00000376788
    ENST00000540495 ENST00000541205

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    Inhib. RNA
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    Additional cDNA sequence: 

    AB209436.1 AF254409.1 AF515445.1 AK124112.1 AK302779.1 AK304730.1 BC034322.1 BC080647.1 
    BC093732.1 BC112037.1 BC143319.1 Z22555.1 

    24/37 DOTS entries (see all 37):

    DT.100882046  DT.100882059  DT.318393  DT.97849883  DT.95319154  DT.100882044  DT.100645767  DT.102834463 
    DT.101983995  DT.424994  DT.100733623  DT.121203134  DT.100843852  DT.100763417  DT.100882058  DT.100882063 
    DT.95262103  DT.97849880  DT.100882053  DT.100882023  DT.121202819  DT.121202863  DT.100799627  DT.100882041 

    24/54 AceView cDNA sequences (see all 54):

    AA341604 AI160219 CA394938 AW050932 BQ877329 BG741048 BI915510 BP350733 
    CR616190 BQ431992 AI744069 AI383019 AI636316 BI829800 AA764923 BE275786 
    CB266465 CR600982 CR599999 AI371524 AW664449 AW006991 BG760684 BX090902 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SCARB1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16
    SP1:                    -     -     -                                                                                   -     -     -     -               
    SP2:                                                                                                                                                      
    SP3:                    -     -     -                                                                                                                     
    SP4:                                                                                                                    -     -     -     -     -         
    SP5:                                -                                                                                                                     


    ECgene alternative splicing isoforms for SCARB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCARB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGACGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SCARB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SCARB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCARB1

    SOURCE GeneReport for Unigene cluster: Hs.731377

    UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SCARB1 gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SCARB11 scavenger receptor class B, member 1 66.6(n)
    60.29(a)
      416814  XM_415106.2  XP_415106.2 
    lizard
    (Anolis carolinensis)
    Reptilia SCARB16
    --
    59(a)
    1 ↔ 1
    LGb(1343011-1368336)
    zebrafish
    (Danio rerio)
    Actinopterygii scarb12 scavenger receptor class B, member 1 76.83(n)   387260  BC044516.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta emp1 epithelial membrane protein 46.33(n)
    33.55(a)
      37999  NM_166703.2  NP_726505.1 
    worm
    (Caenorhabditis elegans)
    Secernentea scav-36
    scav-26
    (see all 6)
    --
    21(a)
    21(a)
    (see all 6)
    possible ortholog
    possible ortholog
    (see all 6)
    III(12453487-12456751)
    III(13551081-13555233)


    ENSEMBL Gene Tree for SCARB1 (if available)
    TreeFam Gene Tree for SCARB1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCARB1 gene
    SCARB22  CD362  
    2 SIMAP similar genes for SCARB1 using alignment to 7 protein entries:     SCRB1_HUMAN (see all proteins):
    SCARB2    CD36

    SCARB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SCARB1
    PGOHUM00000241458


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: SCRB1_HUMAN, Q8WTV0
    Polymorphism: Genetic variations in SCARB1 define the high density lipoprotein cholesterol level quantitative trait
    locus 6 (HDLCQ16) [MIM:610762]


    10/1847 NCBI SNPs in SCARB1 are shown (see all 1847    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764652251,2
    C,F,--122223749(+) ACCCGC/TTTCTC 2 -- ds50011Minor allele frequency- T:0.07WA 118
    rs103962111,2
    F,H,--122224303(-) GCCCAG/CGCTGA 2 -- ut31 ese319Minor allele frequency- C:0.03MN NA EA NS WA 1924
    rs580323861,2
    C,F,--122224487(+) AGTCCG/AGCCGG 2 -- ut311Minor allele frequency- A:0.14WA 118
    rs7471551,2
    A,--122225222(+) cccccG/Accacc 2 -- int12Minor allele frequency- A:0.04NA WA 120
    rs780080881,2
    C,--122226055(+) TGAGAC/TGCTGG 2 -- int11Minor allele frequency- T:0.50WA 2
    rs79692871,2
    C,F,H,--122226170(+) AAAATT/GAAAAA 2 -- int15Minor allele frequency- G:0.01NS EA WA 510
    rs757848961,2
    C,--122226304(+) CCTCCG/ACCCAC 2 -- int11Minor allele frequency- A:0.50WA 2
    rs795159291,2
    C,F,--122226598(+) AAACCC/TGCAGG 2 -- int11Minor allele frequency- T:0.15WA 118
    rs748953491,2
    --122226689(+) TTGGCA/GTGGAA 2 -- int10--------
    rs762536951,2
    C,F,--122227498(+) CACTAC/TGGTGT 2 -- int11Minor allele frequency- T:0.21WA 118

    HapMap Linkage Disequilibrium report for SCARB1 (125261606 - 125367214 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SCARB1
         1 CNV: 5700
         1 Indel: 44982
    Human Gene Mutation Database (HGMD): SCARB1

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SCARB1 for disorders           About GeneDecksing

    OMIM gene information: 601040   
    OMIM disorders: 610762  
    20/56 diseases for SCARB1 (see all 56):    About MalaCards
    high density lipoprotien cholesterol level qtl6    neutrophil-specific granule deficiency    specific granule deficiency    platelet glycoprotein iv deficiency
    hepatitis c    glycogen storage disease type ia    cholesterol    glycogen storage disease
    age related macular degeneration    cetp deficiency    hepatitis    leydig cell tumor
    hyperalphalipoproteinemia    type 2 diabetes mellitus    coronary heart disease    macular degeneration
    primary biliary cirrhosis    addison's disease    insulin resistance    myocardial infarction

    3 diseases from the University of Copenhagen DISEASES database for SCARB1:
    Atherosclerosis     Malaria     Diabetes mellitus

    10/30 Novoseek disease relationships for SCARB1 gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cetp deficiency 70.5 1 15064092 (1)
    atherosclerosis 70.4 49 17272756 (5), 16122381 (4), 16133421 (3), 20137092 (3) (see all 29)
    hyperalphalipoproteinemia 69.1 1 19158204 (1)
    hepatitis c 45.3 9 19828610 (1), 15998599 (1), 19087225 (1), 19094442 (1) (see all 8)
    atherosclerotic plaque 44.2 8 16122381 (2), 15970294 (1), 20137092 (1), 12615688 (1) (see all 7)
    leydig cell tumor 35.4 1 9253328 (1)
    cardiovascular diseases 26.3 4 19837407 (1), 20064494 (1), 19718657 (1)
    dyslipidemia 26.2 2 17700364 (1), 16501936 (1)
    coronary artery disease 25.8 7 11861414 (1), 12227853 (1), 17618962 (1), 16542392 (1) (see all 6)
    carcinoma adrenocortical 24.7 3 12668173 (1), 10215860 (1), 9253328 (1)

    Genetic Association Database (GAD): SCARB1
    Human Genome Epidemiology (HuGE) Navigator: SCARB1 (57 documents)

    Export disorders for SCARB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCARB1 gene, integrated from 9 sources (see all 512):
    (articles sorted by number of sources associating them with SCARB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. (PubMed id 7689561)1, 2, 3, 9 Calvo D. and Vega M. (1993)
    2. Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia. (PubMed id 12519372)1, 2, 4 Tai E.S.... Carmena R. (2003)
    3. Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study. (PubMed id 15910850)1, 4, 9 Richard E....McCarthy J.J. (2005)
    4. Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study. (PubMed id 12788901)1, 4, 9 Osgood D....Ordovas J.M. (2003)
    5. Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations. (PubMed id 15681296)1, 4, 9 Rodriguez-Esparragon F....Ferrario C.M. (2005)
    6. Population-based study of SR-BI genetic variation and lipid profile. (PubMed id 15186961)1, 4, 9 Morabia A....Gilliam T.C. (2004)
    7. Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. (PubMed id 12913001)1, 2, 9 Bartosch B.... Cosset F.-L. (2003)
    8. Association between HaeIII polymorphism of scavenger receptor class B type I gene and plasma HDL-cholesterol concentration. (PubMed id 12227853)1, 4, 9 Hong S.H....Kim J.Q. (2002)
    9. Relationship of genetic variation in genes encoding apolipoprotein A-IV, scavenger receptor BI, HMG-CoA reductase, CETP and apolipoprotein E with cholesterol metabolism and the response to plant stanol ester consumption. (PubMed id 11952809)1, 4, 9 Plat J. and Mensink R.P. (2002)
    10. Molecular genetic analysis of familial hypercholesterolemia: spectrum and regional difference of LDL receptor gene mutations in Japanese population. (PubMed id 12417285)1, 4, 9 Yu W....Mabuchi H. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 949 HGNC: 1664 AceView: SCARB1 Ensembl:ENSG00000073060 euGenes: HUgn949
    ECgene: SCARB1 Kegg: 949 H-InvDB: SCARB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCARB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCARB1 gene:
    Search GeneIP for patents involving SCARB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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