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SCARA5 Gene

protein-coding   GIFtS: 55
GCID: GC08M027727

Scavenger Receptor Class A, Member 5 (Putative)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Scavenger Receptor Class A, Member 5 (Putative)1 2
Scavenger Receptor Hlg2 3
NET332
Tesr2
Scavenger Receptor Class A Member 52
Testis Expressed Scavenger Receptor2

External Ids:    HGNC: 287011   Entrez Gene: 2861332   Ensembl: ENSG000001680797   OMIM: 6113065   UniProtKB: Q6ZMJ23   

Export aliases for SCARA5 gene to outside databases

Previous GC identifers: GC08M027784 GC08M026272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SCARA5 Gene:
SCARA5 (scavenger receptor class A, member 5 (putative)) is a protein-coding gene. Diseases associated with SCARA5 include placenta praevia, and placenta accreta. GO annotations related to this gene include ferritin receptor activity and scavenger receptor activity. An important paralog of this gene is MARCO.

UniProtKB/Swiss-Prot: SCAR5_HUMAN, Q6ZMJ2
Function: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of
ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery
within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types,
suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively
utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of
the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1) (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCARA5 gene promoter:
         Tal-1   NRSF form 1   HSF1 (long)   MyoD   NRSF form 2   E47   AREB6   HSF2   HSF1short   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCARA5 promoter sequence
   Search Chromatin IP Primers for SCARA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCARA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21.1

SCARA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCARA5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M027727:  view genomic region     (about GC identifiers)

Start:
27,727,399 bp from pter      End:
27,850,369 bp from pter
Size:
122,971 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SCAR5_HUMAN, Q6ZMJ2 (See protein sequence)
Recommended Name: Scavenger receptor class A member 5  
Size: 495 amino acids; 53994 Da
Subunit: Homotrimer (By similarity)
Secondary accessions: Q6UXZ1 Q7Z4A1 Q8N4Z7
Alternative splicing: 4 isoforms:  Q6ZMJ2-1   Q6ZMJ2-2   Q6ZMJ2-3   Q6ZMJ2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCARA5: NX_Q6ZMJ2

Explore proteomics data for SCARA5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn102, Asn134, Asn193, Asn231, Asn254, Asn300, Asn397
  • Modification sites at PhosphoSitePlus

  • See SCARA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_776194.2  
    ENSEMBL proteins: 
     ENSP00000346990   ENSP00000369746   ENSP00000428663   ENSP00000430713   ENSP00000301906  
    Reactome Protein details: Q6ZMJ2

    SCARA5 Human Recombinant Protein Products:

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    Novus Biologicals SCARA5 Protein
    Novus Biologicals SCARA5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCARA5

    SCARA5 Antibody Products:

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    SCARA5 Assay Products:

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    Cloud-Clone Corp. CLIAs for SCARA5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001190 SRCR
     IPR017448 Srcr_rcpt-rel
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q6ZMJ2

    ProtoNet protein and cluster: Q6ZMJ2

    2 Blocks protein domains:
    IPB001190 Speract/scavenger receptor
    IPB008160 Collagen triple helix repeat


    UniProtKB/Swiss-Prot: SCAR5_HUMAN, Q6ZMJ2
    Similarity: Belongs to the SCARA5 family
    Similarity: Contains 1 collagen-like domain
    Similarity: Contains 1 SRCR domain


    SCARA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCAR5_HUMAN, Q6ZMJ2
    Function: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of
    ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery
    within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types,
    suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively
    utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of
    the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1) (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding ----
    GO:0070287ferritin receptor activity ISS--
         
    SCARA5 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Scara5):
     endocrine/exocrine gland  immune system  integument  liver/biliary system  renal/urinary system 
     reproductive system  respiratory system 

    SCARA5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Scara5tm1Ktry for SCARA5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCARA5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCARA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCARA5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCARA5

    miRNA
    Products:
        
    miRTarBase miRNAs that target SCARA5:
    hsa-mir-335-5p (MIRT018593)

    Block miRNA regulation of human, mouse, rat SCARA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCARA5 (see all 24):
    hsa-miR-411* hsa-miR-30c hsa-miR-125a-5p hsa-miR-379* hsa-miR-520d-5p hsa-miR-411 hsa-miR-30d hsa-miR-1295
    SwitchGear 3'UTR luciferase reporter plasmidSCARA5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SCARA5
    Predesigned siRNA for gene silencing in human, mouse, rat SCARA5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCARA5

    Clone
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    OriGene ORF clones in mouse, rat for SCARA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCARA5 (NM_173833)
    Sino Biological Human cDNA Clone for SCARA5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCARA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCARA5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SCARA5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCARA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCAR5_HUMAN, Q6ZMJ2: Cell membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane ISS--
    GO:0009986cell surface IEA--
    GO:0016020membrane ----

    SCARA5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SCARA5 About    
    See pathways by source

    SuperPathContained pathways About
    1Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging by Class A Receptors0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SCARA5
        Scavenging by Class A Receptors



    SCARA5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCARA5
    Interactions:

        Search GeneGlobe Interaction Network for SCARA5

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006879cellular iron ion homeostasis ISS--
    GO:0006897endocytosis ISS--
    GO:0006898receptor-mediated endocytosis ISS--
    GO:0034605cellular response to heat IEA--
    GO:0034755iron ion transmembrane transport ISS--

    SCARA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCARA5 (SCAR5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SCARA5 gene: 
    NM_173833.5  

    Unigene Cluster for SCARA5:

    Scavenger receptor class A, member 5 (putative)
    Hs.591833  [show with all ESTs]
    Unigene Representative Sequence: NM_173833
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354914(uc003xgj.3 uc010luz.3) ENST00000380385 ENST00000524352(uc003xgk.3 uc003xgl.3)
    ENST00000518030 ENST00000301906
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCARA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCARA5 (see all 24):
    hsa-miR-411* hsa-miR-30c hsa-miR-125a-5p hsa-miR-379* hsa-miR-520d-5p hsa-miR-411 hsa-miR-30d hsa-miR-1295
    SwitchGear 3'UTR luciferase reporter plasmidSCARA5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SCARA5
    Predesigned siRNA for gene silencing in human, mouse, rat SCARA5
    Clone
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    OriGene clones in human, mouse for SCARA5 (see all 6)
    OriGene ORF clones in mouse, rat for SCARA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCARA5 (NM_173833)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCARA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCARA5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SCARA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCARA5
      QuantiTect SYBR Green Assays in human, mouse, rat SCARA5
      QuantiFast Probe-based Assays in human, mouse, rat SCARA5

    Additional mRNA sequence: 

    AK172746.1 AK301006.1 AY337579.1 AY358150.1 BC033153.1 

    8 DOTS entries:

    DT.97777357  DT.92038440  DT.120632606  DT.101978433  DT.120632604  DT.91751518  DT.95151312  DT.99941666 

    Selected AceView cDNA sequences (see all 43):

    D38723 CR604114 BQ944057 BX359494 CA436066 AA813769 BC033153 NM_173833 
    CA389501 AI240385 AA552012 AY358150 AI989345 BF305634 AI207777 AY337579 
    BX327212 AI245631 CD516014 CD516873 CA389502 AI277612 AK172746 BQ441688 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SCARA5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:                                                  -                                                     -     -               
    SP2:                                                  -           -     -     -     -                       -     -               
    SP3:                                                  -                                                                           
    SP4:                                                  -     -                                                                     
    SP5:                          -     -     -           -                                                                           


    ECgene alternative splicing isoforms for SCARA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCARA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCCCTTGC
    SCARA5 Expression
    About this image


    SCARA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
    SCARA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCARA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591833
        Custom PCR Arrays for SCARA5
    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat SCARA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCARA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SCARA5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scara51 , 5 scavenger receptor class A, member 5 (putative)1, 5 85.55(n)1
    88.75(a)1
      14 (34.35 cM)5
    711451  NM_028903.21  NP_083179.21 
     656664035 
    chicken
    (Gallus gallus)
    Aves SCARA51 scavenger receptor class A, member 5 (putative) 71.92(n)
    67.08(a)
      771061  XM_004935849.1  XP_004935906.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    78(a)
    58(a)
    many → 1
    many → 1
    GL343951.1(95106-97236)
    GL344227.1(41707-51821)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia scara51 scavenger receptor class A, member 5 (putative) 62.45(n)
    62.04(a)
      100497349  XM_002941449.2  XP_002941495.2 
    zebrafish
    (Danio rerio)
    Actinopterygii scara51 scavenger receptor class A, member 5 (putative) 57.53(n)
    50.92(a)
      564500  NM_001030190.1  NP_001025361.1 


    ENSEMBL Gene Tree for SCARA5 (if available)
    TreeFam Gene Tree for SCARA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCARA5 gene
    MARCO2  MSR12  
    1 SIMAP similar gene for SCARA5 using alignment to 1 protein entry:     SCAR5_HUMAN:
    MSR1

    SCARA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCARA5 (see all 2871)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913603101,2
    --27726904(+) GCATGC/TGACCA 1 -- int10--------
    rs1145341211,2
    F--27727011(+) GACCCG/ACTACC 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1165609541,2
    F--27727049(+) ACGGAA/GCTCCG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1448413251,2
    --27727081(+) GAGGAC/TTCTGG 1 -- int10--------
    rs1826758121,2
    --27727173(+) TGTTCC/TGTTGC 1 -- int10--------
    rs78146751,2
    C,F--27727288(+) TCCTAT/CAAGCT 1 -- int14Minor allele frequency- C:0.11WA CSA EA 242
    rs1485752971,2
    --27727294(+) AAGCTA/GCCCAC 1 -- int10--------
    rs78149681,2
    C,F,A,H--27727432(+) ATTCTC/G/TTCTTA 2 -- ut3129NS EA NA WA CSA 2706
    rs1420031561,2
    --27727499(+) GGCCCA/GTGGTC 1 -- ut310--------
    rs777690351,2
    C,F--27727540(+) ACTAGT/CAGACT 1 -- ut311Minor allele frequency- C:0.06NA 120

    HapMap Linkage Disequilibrium report for SCARA5 (27727399 - 27850369 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SCARA5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736804CNV Deletion23290073
    esv2736803CNV Deletion23290073
    esv2736808CNV Deletion23290073
    esv2736805CNV Deletion23290073
    esv1383761CNV Deletion17803354
    nsv509259CNV Insertion20534489
    nsv6133CNV Insertion18451855
    nsv396611CNV Loss16902084
    esv28266CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611306    OMIM disorders: --

    4 diseases for SCARA5:    
    About MalaCards
    placenta praevia    placenta accreta    ectopic pregnancy    venous thrombosis

    2 diseases from the University of Copenhagen DISEASES database for SCARA5:
    Placenta praevia     Placenta accreta

    SCARA5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SCARA5
    Human Genome Epidemiology (HuGE) Navigator: SCARA5 (2 documents)

    Export disorders for SCARA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCARA5 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SCARA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    7. Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides. (PubMed id 22138034)1 Ezzat K....Langel U. (FASEB J. 2012)
    8. Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels. (PubMed id 21029358)1 Morange P.E....TrAcgouAt D.A. (J. Thromb. Haemost. 2011)
    9. Ectopic pregnancy as a model to identify endometrial genes and signaling pathways important in decidualization and regulated by local trophoblast. (PubMed id 21858178)1 Duncan W.C....Horne A.W. (PLoS ONE 2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 286133 HGNC: 28701 AceView: MGC45780 Ensembl:ENSG00000168079 euGenes: HUgn286133
    ECgene: SCARA5 H-InvDB: SCARA5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCARA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SCARA5 gene:
    Search GeneIP for patents involving SCARA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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