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Aliases for SCARA5 Gene

Aliases for SCARA5 Gene

  • Scavenger Receptor Class A Member 5 2 3 5
  • Scavenger Receptor Class A, Member 5 (Putative) 2 3
  • Scavenger Receptor Hlg 3 4
  • Scavenger Receptor Class A, Member 5 2
  • Testis Expressed Scavenger Receptor 3
  • NET33 3
  • Tesr 3

External Ids for SCARA5 Gene

Previous GeneCards Identifiers for SCARA5 Gene

  • GC08M027784
  • GC08M026272
  • GC08M027727

Summaries for SCARA5 Gene

GeneCards Summary for SCARA5 Gene

SCARA5 (Scavenger Receptor Class A Member 5) is a Protein Coding gene. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport. GO annotations related to this gene include scavenger receptor activity and ferritin receptor activity. An important paralog of this gene is MSR1.

UniProtKB/Swiss-Prot for SCARA5 Gene

  • Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARA5 Gene

Genomics for SCARA5 Gene

Regulatory Elements for SCARA5 Gene

Enhancers for SCARA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G027945 1.3 Ensembl ENCODE 17.3 +45.1 45139 4.6 PKNOX1 FEZF1 ZNF2 ZNF766 ZNF263 SP3 REST ZNF610 SMARCA4 ZNF585B SCARA5 ENSG00000253397
GH08G027863 1.2 Ensembl ENCODE dbSUPER 11.5 +128.8 128765 0.7 ELF3 CTCF ZNF384 RAD21 ZNF366 ZBTB48 PATZ1 ZNF350 ZNF143 SMC3 SCARA5 LOC100130612 PBK CCDC25 MIR4287
GH08G027915 1.1 dbSUPER 11.6 +76.2 76236 2.0 HDGF CREB3L1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 SCARA5 LOC100130612 PBK ENSG00000253397
GH08G027855 0.9 ENCODE dbSUPER 11.2 +136.4 136393 1.3 CTCF CBX3 REST RAD21 CHAMP1 RFX5 GTF3C2 ATF3 ZNF512 ZNF580 CCDC25 ZNF395 SCARA5 NUGGC LOC100130612 MIR4287
GH08G028032 0.8 ENCODE 11.6 -40.7 -40689 1.6 KAT2B RARA CREM MIXL1 SP5 KAT8 CEBPA HNF4A SOX13 CTCF SCARA5 NUGGC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCARA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCARA5 Gene

Chromosome:
8
Start:
27,869,882 bp from pter
End:
27,992,852 bp from pter
Size:
122,971 bases
Orientation:
Minus strand

Genomic View for SCARA5 Gene

Genes around SCARA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCARA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCARA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARA5 Gene

Proteins for SCARA5 Gene

  • Protein details for SCARA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMJ2-SCAR5_HUMAN
    Recommended name:
    Scavenger receptor class A member 5
    Protein Accession:
    Q6ZMJ2
    Secondary Accessions:
    • Q6UXZ1
    • Q7Z4A1
    • Q8N4Z7

    Protein attributes for SCARA5 Gene

    Size:
    495 amino acids
    Molecular mass:
    53994 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for SCARA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCARA5 Gene

Post-translational modifications for SCARA5 Gene

  • Glycosylation at Asn102, isoforms=2, 3134, Asn193, isoforms=2, 3231, Asn254, Asn300, and Asn397
  • Modification sites at PhosphoSitePlus

Other Protein References for SCARA5 Gene

Antibody Products

  • Abcam antibodies for SCARA5

No data available for DME Specific Peptides for SCARA5 Gene

Domains & Families for SCARA5 Gene

Suggested Antigen Peptide Sequences for SCARA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMJ2

UniProtKB/Swiss-Prot:

SCAR5_HUMAN :
  • Belongs to the SCARA5 family.
Family:
  • Belongs to the SCARA5 family.
genes like me logo Genes that share domains with SCARA5: view

Function for SCARA5 Gene

Molecular function for SCARA5 Gene

UniProtKB/Swiss-Prot Function:
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).

Gene Ontology (GO) - Molecular Function for SCARA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0070287 ferritin receptor activity ISS --
genes like me logo Genes that share ontologies with SCARA5: view
genes like me logo Genes that share phenotypes with SCARA5: view

Animal Models for SCARA5 Gene

MGI Knock Outs for SCARA5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SCARA5

CRISPR Products

miRNA for SCARA5 Gene

miRTarBase miRNAs that target SCARA5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCARA5 Gene

Localization for SCARA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARA5 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCARA5 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SCARA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane ISS --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCARA5: view

Pathways & Interactions for SCARA5 Gene

genes like me logo Genes that share pathways with SCARA5: view

Pathways by source for SCARA5 Gene

Interacting Proteins for SCARA5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000346990%0d%0a9606.ENSP00000273550%0d%0a9606.ENSP00000366525%0d%0a
Selected Interacting proteins: ENSP00000346990 Q6ZMJ2-SCAR5_HUMAN for SCARA5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SCARA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006879 cellular iron ion homeostasis ISS --
GO:0006897 endocytosis ISS --
GO:0006898 receptor-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with SCARA5: view

No data available for SIGNOR curated interactions for SCARA5 Gene

Drugs & Compounds for SCARA5 Gene

No Compound Related Data Available

Transcripts for SCARA5 Gene

Unigene Clusters for SCARA5 Gene

Scavenger receptor class A, member 5 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCARA5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6:
SP7: - -

Relevant External Links for SCARA5 Gene

GeneLoc Exon Structure for
SCARA5
ECgene alternative splicing isoforms for
SCARA5

Expression for SCARA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCARA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCARA5 Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.9).

Protein differential expression in normal tissues from HIPED for SCARA5 Gene

This gene is overexpressed in Pancreatic juice (16.9), Gallbladder (16.7), Testis (10.7), Urinary Bladder (9.2), and Cerebral cortex (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCARA5 Gene



NURSA nuclear receptor signaling pathways regulating expression of SCARA5 Gene:

SCARA5

SOURCE GeneReport for Unigene cluster for SCARA5 Gene:

Hs.591833

Evidence on tissue expression from TISSUES for SCARA5 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with SCARA5: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCARA5 Gene

Orthologs for SCARA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCARA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCARA5 34 35
  • 96.77 (n)
dog
(Canis familiaris)
Mammalia SCARA5 34 35
  • 91.97 (n)
cow
(Bos Taurus)
Mammalia SCARA5 34 35
  • 89 (n)
mouse
(Mus musculus)
Mammalia Scara5 34 16 35
  • 85.55 (n)
rat
(Rattus norvegicus)
Mammalia Scara5 34
  • 83.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SCARA5 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCARA5 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCARA5 34 35
  • 71.92 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 78 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia scara5 34
  • 62.45 (n)
zebrafish
(Danio rerio)
Actinopterygii scara5 34 35
  • 57.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for SCARA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCARA5 Gene

ENSEMBL:
Gene Tree for SCARA5 (if available)
TreeFam:
Gene Tree for SCARA5 (if available)

Paralogs for SCARA5 Gene

Paralogs for SCARA5 Gene

(1) SIMAP similar genes for SCARA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCARA5: view

Variants for SCARA5 Gene

Sequence variations from dbSNP and Humsavar for SCARA5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000008064 -- 27,986,918(+) AGCTG(A/G)TGGAA intron-variant
rs1000056635 -- 27,979,251(+) AAAAA(A/C)CAGAA intron-variant
rs1000058409 -- 27,984,742(+) ATTCA(G/T)CCATT intron-variant
rs1000071709 -- 27,879,830(+) GGGCC(G/T)TCTTT intron-variant
rs1000193685 -- 27,946,880(+) AAACT(C/T)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCARA5 Gene

Variant ID Type Subtype PubMed ID
dgv7155n100 CNV gain 25217958
dgv7156n100 CNV gain 25217958
esv1383761 CNV deletion 17803354
esv2736803 CNV deletion 23290073
esv2736804 CNV deletion 23290073
esv2736805 CNV deletion 23290073
esv2736808 CNV deletion 23290073
esv28266 CNV gain 19812545
esv3543273 CNV deletion 23714750
esv3616729 CNV loss 21293372
nsv1017121 CNV gain 25217958
nsv1019421 CNV gain 25217958
nsv1137356 CNV deletion 24896259
nsv1147479 CNV deletion 26484159
nsv1153116 CNV deletion 26484159
nsv396611 CNV deletion 16902084
nsv474762 CNV novel sequence insertion 20440878
nsv509259 CNV insertion 20534489
nsv610868 CNV loss 21841781
nsv6133 CNV insertion 18451855
nsv951119 CNV deletion 24416366
nsv967573 CNV duplication 23825009

Variation tolerance for SCARA5 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.62; 82.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCARA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCARA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCARA5 Gene

Disorders for SCARA5 Gene

Relevant External Links for SCARA5

Genetic Association Database (GAD)
SCARA5
Human Genome Epidemiology (HuGE) Navigator
SCARA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCARA5

No disorders were found for SCARA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCARA5 Gene

Publications for SCARA5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. (PMID: 19154717) Li J.Y. … Barasch J. (Dev. Cell 2009) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for SCARA5 Gene

Sources for SCARA5 Gene

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