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Aliases for SCARA5 Gene

Aliases for SCARA5 Gene

  • Scavenger Receptor Class A, Member 5 2 3
  • Scavenger Receptor Class A, Member 5 (Putative) 2 3
  • Scavenger Receptor Hlg 3 4
  • Testis Expressed Scavenger Receptor 3
  • NET33 3
  • Tesr 3

External Ids for SCARA5 Gene

Previous GeneCards Identifiers for SCARA5 Gene

  • GC08M027784
  • GC08M026272
  • GC08M027727

Summaries for SCARA5 Gene

GeneCards Summary for SCARA5 Gene

SCARA5 (Scavenger Receptor Class A, Member 5) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include scavenger receptor activity and ferritin receptor activity. An important paralog of this gene is MARCO.

UniProtKB/Swiss-Prot for SCARA5 Gene

  • Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARA5 Gene

Genomics for SCARA5 Gene

Regulatory Elements for SCARA5 Gene

Genomic Location for SCARA5 Gene

Chromosome:
8
Start:
27,869,882 bp from pter
End:
27,992,852 bp from pter
Size:
122,971 bases
Orientation:
Minus strand

Genomic View for SCARA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCARA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARA5 Gene

Proteins for SCARA5 Gene

  • Protein details for SCARA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMJ2-SCAR5_HUMAN
    Recommended name:
    Scavenger receptor class A member 5
    Protein Accession:
    Q6ZMJ2
    Secondary Accessions:
    • Q6UXZ1
    • Q7Z4A1
    • Q8N4Z7

    Protein attributes for SCARA5 Gene

    Size:
    495 amino acids
    Molecular mass:
    53994 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for SCARA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCARA5 Gene

Proteomics data for SCARA5 Gene at MOPED

Post-translational modifications for SCARA5 Gene

  • Glycosylation at Asn 102, Asn 134, Asn 193, Asn 231, Asn 254, Asn 300, and Asn 397
  • Modification sites at PhosphoSitePlus

Other Protein References for SCARA5 Gene

Antibody Products

No data available for DME Specific Peptides for SCARA5 Gene

Domains & Families for SCARA5 Gene

Protein Domains for SCARA5 Gene

Suggested Antigen Peptide Sequences for SCARA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMJ2

UniProtKB/Swiss-Prot:

SCAR5_HUMAN :
  • Contains 1 collagen-like domain.
  • Belongs to the SCARA5 family.
Domain:
  • Contains 1 collagen-like domain.
  • Contains 1 SRCR domain.
Family:
  • Belongs to the SCARA5 family.
genes like me logo Genes that share domains with SCARA5: view

No data available for Gene Families for SCARA5 Gene

Function for SCARA5 Gene

Molecular function for SCARA5 Gene

UniProtKB/Swiss-Prot Function:
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1) (By similarity).

Gene Ontology (GO) - Molecular Function for SCARA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding --
GO:0070287 ferritin receptor activity ISS --
genes like me logo Genes that share ontologies with SCARA5: view
genes like me logo Genes that share phenotypes with SCARA5: view

Animal Models for SCARA5 Gene

MGI Knock Outs for SCARA5:

Animal Model Products

miRNA for SCARA5 Gene

miRTarBase miRNAs that target SCARA5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCARA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SCARA5 Gene

Localization for SCARA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARA5 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCARA5 Gene COMPARTMENTS Subcellular localization image for SCARA5 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SCARA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane ISS --
GO:0009986 cell surface IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SCARA5: view

Pathways & Interactions for SCARA5 Gene

genes like me logo Genes that share pathways with SCARA5: view

Pathways by source for SCARA5 Gene

Interacting Proteins for SCARA5 Gene

Gene Ontology (GO) - Biological Process for SCARA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006879 cellular iron ion homeostasis ISS --
GO:0006897 endocytosis ISS --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0010468 regulation of gene expression IMP 21810271
GO:0030193 regulation of blood coagulation IMP 21810271
genes like me logo Genes that share ontologies with SCARA5: view

No data available for SIGNOR curated interactions for SCARA5 Gene

Drugs & Compounds for SCARA5 Gene

No Compound Related Data Available

Transcripts for SCARA5 Gene

Unigene Clusters for SCARA5 Gene

Scavenger receptor class A, member 5 (putative):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCARA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCARA5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6:
SP7: - -

Relevant External Links for SCARA5 Gene

GeneLoc Exon Structure for
SCARA5
ECgene alternative splicing isoforms for
SCARA5

Expression for SCARA5 Gene

mRNA expression in normal human tissues for SCARA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCARA5 Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.9).

Protein differential expression in normal tissues from HIPED for SCARA5 Gene

This gene is overexpressed in Pancreatic juice (16.9), Gallbladder (16.7), Testis (10.7), Urinary Bladder (9.2), and Cerebral cortex (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCARA5 Gene



SOURCE GeneReport for Unigene cluster for SCARA5 Gene Hs.591833

genes like me logo Genes that share expression patterns with SCARA5: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SCARA5 Gene

Orthologs for SCARA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCARA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCARA5 35
  • 89 (n)
  • 88.87 (a)
SCARA5 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCARA5 35
  • 91.97 (n)
  • 93.12 (a)
SCARA5 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scara5 35
  • 85.55 (n)
  • 88.75 (a)
Scara5 16
Scara5 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCARA5 35
  • 96.77 (n)
  • 96.77 (a)
SCARA5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scara5 35
  • 83.91 (n)
  • 87.53 (a)
oppossum
(Monodelphis domestica)
Mammalia SCARA5 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCARA5 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCARA5 35
  • 71.92 (n)
  • 67.08 (a)
SCARA5 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia scara5 35
  • 62.45 (n)
  • 62.04 (a)
zebrafish
(Danio rerio)
Actinopterygii scara5 35
  • 57.53 (n)
  • 50.92 (a)
scara5 36
  • 47 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for SCARA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCARA5 Gene

ENSEMBL:
Gene Tree for SCARA5 (if available)
TreeFam:
Gene Tree for SCARA5 (if available)

Paralogs for SCARA5 Gene

Paralogs for SCARA5 Gene

(1) SIMAP similar genes for SCARA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCARA5: view

Variants for SCARA5 Gene

Sequence variations from dbSNP and Humsavar for SCARA5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs526301 -- 27,871,080(-) GTGCA(C/G)GACCT utr-variant-3-prime
rs556451 -- 27,870,109(-) CTTGG(G/T)CTTTC utr-variant-3-prime
rs756187 -- 27,916,782(+) CTGGA(G/T)GCCCA intron-variant
rs868189 -- 27,894,319(+) GAGGC(A/G)ACTCT intron-variant
rs875164 -- 27,875,048(+) CCAGA(C/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCARA5 Gene

Variant ID Type Subtype PubMed ID
nsv6133 CNV Insertion 18451855
nsv509259 CNV Insertion 20534489
esv28266 CNV Gain 19812545
esv2736803 CNV Deletion 23290073
esv2736804 CNV Deletion 23290073
esv2736805 CNV Deletion 23290073
esv2736808 CNV Deletion 23290073
esv1383761 CNV Deletion 17803354
nsv396611 CNV Loss 16902084

Variation tolerance for SCARA5 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.62; 82.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCARA5 Gene

HapMap Linkage Disequilibrium report
SCARA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCARA5 Gene

Disorders for SCARA5 Gene

Relevant External Links for SCARA5

Genetic Association Database (GAD)
SCARA5
Human Genome Epidemiology (HuGE) Navigator
SCARA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCARA5
genes like me logo Genes that share disorders with SCARA5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCARA5 Gene

Publications for SCARA5 Gene

  1. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. (PMID: 19154717) Li J.Y. … Barasch J. (Dev. Cell 2009) 2 67
  2. L-ferritin binding to scara5: a new iron traffic pathway potentially implicated in retinopathy. (PMID: 25259650) Mendes-Jorge L. … Ruberte J. (PLoS ONE 2014) 67
  3. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 67
  4. Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides. (PMID: 22138034) Ezzat K. … Langel U. (FASEB J. 2012) 67
  5. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. (PMID: 21810271) Antoni G. … Tregouet D.A. (BMC Med. Genet. 2011) 67

Products for SCARA5 Gene

Sources for SCARA5 Gene

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