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Aliases for SCARA3 Gene

Aliases for SCARA3 Gene

  • Scavenger Receptor Class A Member 3 2 3 5
  • Cellular Stress Response Gene Protein 3 4
  • Macrophage Scavenger Receptor-Like 1 2 3
  • CSR 3 4
  • Scavenger Receptor Class A, Member 3 2
  • Cellular Stress Response Protein 3
  • MSLR1 3
  • MSRL1 3
  • APC7 3
  • CSR1 3

External Ids for SCARA3 Gene

Previous GeneCards Identifiers for SCARA3 Gene

  • GC08P027274
  • GC08P027996
  • GC08P027513
  • GC08P027547
  • GC08P027492
  • GC08P026036

Summaries for SCARA3 Gene

Entrez Gene Summary for SCARA3 Gene

  • This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCARA3 Gene

SCARA3 (Scavenger Receptor Class A Member 3) is a Protein Coding gene. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is COLEC12.

UniProtKB/Swiss-Prot for SCARA3 Gene

  • Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.

Additional gene information for SCARA3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARA3 Gene

Genomics for SCARA3 Gene

Regulatory Elements for SCARA3 Gene

Enhancers for SCARA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H027635 1.3 FANTOM5 Ensembl ENCODE 15.6 +3.3 3251 2 CTCF KLF1 CEBPB DPF2 RAD21 ZNF121 CTBP1 ZNF692 HSF1 ZNF341 SCARA3 CLU STMN4 CHRNA2 RNU6-1086P
GH08H027675 1.1 Ensembl ENCODE 14.5 +41.4 41433 0 SOX13 CTCF SAP130 ARID4B MAX RAD21 RARA TEAD3 ZNF143 NR2F6 SCARA3 CCDC25 CLU RNU6-1086P
GH08H027701 1.4 Ensembl ENCODE dbSUPER 8.4 +68.9 68865 1 ELF3 TBP FOXA2 ARID4B DMAP1 THRB ZSCAN9 RARA YY1 ZNF366 ENSG00000253875 SCARA3 CLU MIR3622B
GH08H027669 0.7 Ensembl ENCODE 15.1 +36.1 36139 1 GLIS1 ATF2 SCARA3 CLU ENSG00000253875 RNU6-1086P
GH08H027871 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +238.9 238902 2 ATF1 FOXA2 FEZF1 BRCA1 ZNF2 GTF3C2 ZNF121 KLF7 ATF7 FOS ZNF395 CCDC25 SCARA3 PBK ELP3 MIR4287 LOC100130612
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCARA3 on UCSC Golden Path with GeneCards custom track

Promoters for SCARA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222653 132 1201 KLF1 KLF17 ZIC2 E2F1 ZFHX2 GLIS2 POLR2A PATZ1 PRDM10 KLF8

Genomic Location for SCARA3 Gene

Chromosome:
8
Start:
27,633,868 bp from pter
End:
27,712,743 bp from pter
Size:
78,876 bases
Orientation:
Plus strand

Genomic View for SCARA3 Gene

Genes around SCARA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCARA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCARA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARA3 Gene

Proteins for SCARA3 Gene

  • Protein details for SCARA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AZY7-SCAR3_HUMAN
    Recommended name:
    Scavenger receptor class A member 3
    Protein Accession:
    Q6AZY7
    Secondary Accessions:
    • Q9UM15
    • Q9UM16

    Protein attributes for SCARA3 Gene

    Size:
    606 amino acids
    Molecular mass:
    65137 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCARA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCARA3 Gene

Post-translational modifications for SCARA3 Gene

  • Glycosylation at isoforms=2115, Asn182, isoforms=2224, isoforms=2257, isoforms=2313, isoforms=2337, isoforms=2365, Asn400, Asn430, and isoforms=2451
  • Modification sites at PhosphoSitePlus

Other Protein References for SCARA3 Gene

No data available for DME Specific Peptides for SCARA3 Gene

Domains & Families for SCARA3 Gene

Gene Families for SCARA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SCARA3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCARA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SCARA3: view

No data available for UniProtKB/Swiss-Prot for SCARA3 Gene

Function for SCARA3 Gene

Molecular function for SCARA3 Gene

UniProtKB/Swiss-Prot Function:
Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.

Phenotypes From GWAS Catalog for SCARA3 Gene

Gene Ontology (GO) - Molecular Function for SCARA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity TAS 9580669
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SCARA3: view
genes like me logo Genes that share phenotypes with SCARA3: view

Animal Model Products

CRISPR Products

miRNA for SCARA3 Gene

miRTarBase miRNAs that target SCARA3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SCARA3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCARA3 Gene

Localization for SCARA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARA3 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Endoplasmic reticulum and/or Golgi.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCARA3 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
plasma membrane 2
nucleus 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCARA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005581 collagen trimer IEA --
GO:0005783 endoplasmic reticulum IDA,IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with SCARA3: view

Pathways & Interactions for SCARA3 Gene

SuperPathways for SCARA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCARA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006979 response to oxidative stress TAS 9580669
GO:0009650 UV protection TAS 9580669
GO:0034138 NOT toll-like receptor 3 signaling pathway IMP 25204797
genes like me logo Genes that share ontologies with SCARA3: view

No data available for Pathways by source and SIGNOR curated interactions for SCARA3 Gene

Drugs & Compounds for SCARA3 Gene

No Compound Related Data Available

Transcripts for SCARA3 Gene

Unigene Clusters for SCARA3 Gene

Scavenger receptor class A, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SCARA3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SCARA3 Gene

No ASD Table

Relevant External Links for SCARA3 Gene

GeneLoc Exon Structure for
SCARA3
ECgene alternative splicing isoforms for
SCARA3

Expression for SCARA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCARA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCARA3 Gene

This gene is overexpressed in Uterus (51.6) and Placenta (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCARA3 Gene



Protein tissue co-expression partners for SCARA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCARA3 Gene:

SCARA3

SOURCE GeneReport for Unigene cluster for SCARA3 Gene:

Hs.128856

mRNA Expression by UniProt/SwissProt for SCARA3 Gene:

Q6AZY7-SCAR3_HUMAN
Tissue specificity: Expressed ubiquitously.

Evidence on tissue expression from TISSUES for SCARA3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SCARA3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCARA3 Gene

Orthologs for SCARA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCARA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCARA3 33 34
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia SCARA3 33 34
  • 90.18 (n)
cow
(Bos Taurus)
Mammalia SCARA3 33 34
  • 88.39 (n)
mouse
(Mus musculus)
Mammalia Scara3 33 16 34
  • 86.8 (n)
rat
(Rattus norvegicus)
Mammalia Scara3 33
  • 86.25 (n)
oppossum
(Monodelphis domestica)
Mammalia SCARA3 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCARA3 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCARA3 33 34
  • 70.65 (n)
lizard
(Anolis carolinensis)
Reptilia SCARA3 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scara3 33
  • 64.87 (n)
zebrafish
(Danio rerio)
Actinopterygii scara3 33 34
  • 55.25 (n)
worm
(Caenorhabditis elegans)
Secernentea col-148 34
  • 25 (a)
ManyToMany
col-150 34
  • 25 (a)
ManyToMany
col-89 34
  • 25 (a)
ManyToMany
col-10 34
  • 24 (a)
ManyToMany
col-126 34
  • 24 (a)
ManyToMany
col-127 34
  • 24 (a)
ManyToMany
col-144 34
  • 24 (a)
ManyToMany
col-145 34
  • 24 (a)
ManyToMany
col-176 34
  • 24 (a)
ManyToMany
col-61 34
  • 24 (a)
ManyToMany
col-118 34
  • 23 (a)
ManyToMany
col-149 34
  • 23 (a)
ManyToMany
col-187 34
  • 23 (a)
ManyToMany
col-177 34
  • 17 (a)
ManyToMany
Species where no ortholog for SCARA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCARA3 Gene

ENSEMBL:
Gene Tree for SCARA3 (if available)
TreeFam:
Gene Tree for SCARA3 (if available)

Paralogs for SCARA3 Gene

Paralogs for SCARA3 Gene

(1) SIMAP similar genes for SCARA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCARA3: view

Variants for SCARA3 Gene

Sequence variations from dbSNP and Humsavar for SCARA3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000009761 -- 27,729,011(+) AGTGA(A/G)CTGTG intron-variant
rs1000013473 -- 27,644,787(+) TCCTC(G/T)ATTTT intron-variant
rs1000038334 -- 27,690,858(+) TTTAA(C/T)TTTTT intron-variant
rs1000080967 -- 27,650,238(+) GATCT(A/G)CCCGC intron-variant
rs1000111479 -- 27,719,536(+) AAAAG(G/T)TAAAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SCARA3 Gene

Variant ID Type Subtype PubMed ID
dgv3798n106 CNV deletion 24896259
dgv3799n106 CNV tandem duplication 24896259
esv2736798 CNV deletion 23290073
esv3616725 CNV loss 21293372
nsv397633 CNV deletion 16902084
nsv610867 CNV gain 21841781

Variation tolerance for SCARA3 Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCARA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCARA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCARA3 Gene

Disorders for SCARA3 Gene

Relevant External Links for SCARA3

Genetic Association Database (GAD)
SCARA3
Human Genome Epidemiology (HuGE) Navigator
SCARA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCARA3

No disorders were found for SCARA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCARA3 Gene

Publications for SCARA3 Gene

  1. CSR, a scavenger receptor-like protein with a protective role against cellular damage causedby UV irradiation and oxidative stress. (PMID: 9580669) Han HJ … Nakamura Y (Human molecular genetics 1998) 2 3 4 22 60
  2. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Dinucleotide repeat polymorphism in the first intron of the CSR gene. (PMID: 9747040) Han HJ … Nakamura Y (Journal of human genetics 1998) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SCARA3 Gene

Sources for SCARA3 Gene

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