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Aliases for SCARA3 Gene

Aliases for SCARA3 Gene

  • Scavenger Receptor Class A Member 3 2 3 5
  • Cellular Stress Response Gene Protein 3 4
  • Macrophage Scavenger Receptor-Like 1 2 3
  • Scavenger Receptor Class A, Member 3 2 3
  • CSR 3 4
  • Cellular Stress Response Protein 3
  • MSLR1 3
  • MSRL1 3
  • APC7 3
  • CSR1 3

External Ids for SCARA3 Gene

Previous GeneCards Identifiers for SCARA3 Gene

  • GC08P027274
  • GC08P027996
  • GC08P027513
  • GC08P027547
  • GC08P027492
  • GC08P026036

Summaries for SCARA3 Gene

Entrez Gene Summary for SCARA3 Gene

  • This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCARA3 Gene

SCARA3 (Scavenger Receptor Class A Member 3) is a Protein Coding gene. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is COL6A1.

UniProtKB/Swiss-Prot for SCARA3 Gene

  • Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARA3 Gene

Genomics for SCARA3 Gene

Regulatory Elements for SCARA3 Gene

Enhancers for SCARA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCARA3 on UCSC Golden Path with GeneCards custom track

Promoters for SCARA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCARA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCARA3 Gene

Chromosome:
8
Start:
27,633,868 bp from pter
End:
27,712,743 bp from pter
Size:
78,876 bases
Orientation:
Plus strand

Genomic View for SCARA3 Gene

Genes around SCARA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCARA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCARA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARA3 Gene

Proteins for SCARA3 Gene

  • Protein details for SCARA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AZY7-SCAR3_HUMAN
    Recommended name:
    Scavenger receptor class A member 3
    Protein Accession:
    Q6AZY7
    Secondary Accessions:
    • Q9UM15
    • Q9UM16

    Protein attributes for SCARA3 Gene

    Size:
    606 amino acids
    Molecular mass:
    65137 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCARA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCARA3 Gene

Proteomics data for SCARA3 Gene at MOPED

Post-translational modifications for SCARA3 Gene

  • Glycosylation at Asn 115, Asn 182, Asn 224, Asn 257, Asn 313, Asn 337, Asn 365, Asn 400, Asn 430, and Asn 451
  • Modification sites at PhosphoSitePlus

Other Protein References for SCARA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SCARA3 Gene

Domains & Families for SCARA3 Gene

Gene Families for SCARA3 Gene

Protein Domains for SCARA3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCARA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6AZY7

UniProtKB/Swiss-Prot:

SCAR3_HUMAN :
  • Contains 2 collagen-like domains.
Domain:
  • Contains 2 collagen-like domains.
genes like me logo Genes that share domains with SCARA3: view

Function for SCARA3 Gene

Molecular function for SCARA3 Gene

UniProtKB/Swiss-Prot Function:
Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.
genes like me logo Genes that share phenotypes with SCARA3: view

Animal Model Products

miRNA for SCARA3 Gene

miRTarBase miRNAs that target SCARA3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCARA3 Gene

Localization for SCARA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARA3 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Endoplasmic reticulum and/or Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCARA3 Gene COMPARTMENTS Subcellular localization image for SCARA3 gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
nucleus 2
plasma membrane 2
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SCARA3 Gene

Pathways & Interactions for SCARA3 Gene

SuperPathways for SCARA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCARA3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCARA3 Gene

Drugs & Compounds for SCARA3 Gene

No Compound Related Data Available

Transcripts for SCARA3 Gene

Unigene Clusters for SCARA3 Gene

Scavenger receptor class A, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCARA3 Gene

No ASD Table

Relevant External Links for SCARA3 Gene

GeneLoc Exon Structure for
SCARA3
ECgene alternative splicing isoforms for
SCARA3

Expression for SCARA3 Gene

mRNA expression in normal human tissues for SCARA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCARA3 Gene

This gene is overexpressed in Uterus (51.6) and Placenta (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCARA3 Gene



SOURCE GeneReport for Unigene cluster for SCARA3 Gene Hs.128856

mRNA Expression by UniProt/SwissProt for SCARA3 Gene

Q6AZY7-SCAR3_HUMAN
Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expression patterns with SCARA3: view

Protein tissue co-expression partners for SCARA3 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for SCARA3 Gene

Orthologs for SCARA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCARA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCARA3 35
  • 88.39 (n)
  • 89.77 (a)
SCARA3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCARA3 35
  • 90.18 (n)
  • 92.22 (a)
SCARA3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scara3 35
  • 86.8 (n)
  • 90.76 (a)
Scara3 16
Scara3 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCARA3 35
  • 99.17 (n)
  • 99.67 (a)
SCARA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scara3 35
  • 86.25 (n)
  • 91.09 (a)
oppossum
(Monodelphis domestica)
Mammalia SCARA3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCARA3 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCARA3 35
  • 70.65 (n)
  • 66.26 (a)
SCARA3 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCARA3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scara3 35
  • 64.87 (n)
  • 63.41 (a)
zebrafish
(Danio rerio)
Actinopterygii scara3 35
  • 55.25 (n)
  • 47.49 (a)
scara3 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea col-10 36
  • 24 (a)
ManyToMany
col-118 36
  • 23 (a)
ManyToMany
col-126 36
  • 24 (a)
ManyToMany
col-127 36
  • 24 (a)
ManyToMany
col-144 36
  • 24 (a)
ManyToMany
col-145 36
  • 24 (a)
ManyToMany
col-148 36
  • 25 (a)
ManyToMany
col-149 36
  • 23 (a)
ManyToMany
col-150 36
  • 25 (a)
ManyToMany
col-176 36
  • 24 (a)
ManyToMany
col-177 36
  • 17 (a)
ManyToMany
col-187 36
  • 23 (a)
ManyToMany
col-61 36
  • 24 (a)
ManyToMany
col-89 36
  • 25 (a)
ManyToMany
Species with no ortholog for SCARA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCARA3 Gene

ENSEMBL:
Gene Tree for SCARA3 (if available)
TreeFam:
Gene Tree for SCARA3 (if available)

Paralogs for SCARA3 Gene

Paralogs for SCARA3 Gene

(1) SIMAP similar genes for SCARA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCARA3: view

Variants for SCARA3 Gene

Sequence variations from dbSNP and Humsavar for SCARA3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs34791518 - 27,658,559(+) GATCC(A/G)AAAAC nc-transcript-variant, reference, missense
rs33930667 - 27,659,144(+) GAACA(C/T)GCATG nc-transcript-variant, reference, missense
rs3735754 - 27,659,438(-) CCAGC(C/T)GGGCA nc-transcript-variant, reference, missense
rs34086286 - 27,659,452(+) TCAAC(A/G/T)TCCGG nc-transcript-variant, reference, missense
rs17057523 - 27,670,929(+) GAGGA(C/T)TCAAA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SCARA3 Gene

Variant ID Type Subtype PubMed ID
nsv890698 CNV Loss 21882294
nsv397633 CNV Loss 16902084
esv2736798 CNV Deletion 23290073

Variation tolerance for SCARA3 Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCARA3 Gene

Disorders for SCARA3 Gene

Relevant External Links for SCARA3

Genetic Association Database (GAD)
SCARA3
Human Genome Epidemiology (HuGE) Navigator
SCARA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCARA3

No disorders were found for SCARA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCARA3 Gene

Publications for SCARA3 Gene

  1. CSR, a scavenger receptor-like protein with a protective role against cellular damage caused by UV irradiation and oxidative stress. (PMID: 9580669) Han H.-J. … Nakamura Y. (Hum. Mol. Genet. 1998) 2 3 4 23 67
  2. Dinucleotide repeat polymorphism in the first intron of the CSR gene. (PMID: 9747040) Han H.J. … Nakamura Y. (J. Hum. Genet. 1998) 2 3
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A cellular stress response (CSR) that interacts with NADPH-P450 reductase (NPR) is a new regulator of hypoxic response. (PMID: 24491563) Oguro A. … Imaoka S. (Biochem. Biophys. Res. Commun. 2014) 3

Products for SCARA3 Gene

Sources for SCARA3 Gene

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