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Aliases for SCARA3 Gene

Aliases for SCARA3 Gene

  • Scavenger Receptor Class A Member 3 2 3 5
  • Cellular Stress Response Gene Protein 3 4
  • Macrophage Scavenger Receptor-Like 1 2 3
  • CSR 3 4
  • Scavenger Receptor Class A, Member 3 2
  • Cellular Stress Response Protein 3
  • MSLR1 3
  • MSRL1 3
  • APC7 3
  • CSR1 3

External Ids for SCARA3 Gene

Previous GeneCards Identifiers for SCARA3 Gene

  • GC08P027274
  • GC08P027996
  • GC08P027513
  • GC08P027547
  • GC08P027492
  • GC08P026036

Summaries for SCARA3 Gene

Entrez Gene Summary for SCARA3 Gene

  • This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCARA3 Gene

SCARA3 (Scavenger Receptor Class A Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is COLEC12.

UniProtKB/Swiss-Prot for SCARA3 Gene

  • Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.

Additional gene information for SCARA3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARA3 Gene

Genomics for SCARA3 Gene

GeneHancer (GH) Regulatory Elements for SCARA3 Gene

Promoters and enhancers for SCARA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I027633 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 561.7 +0.4 412 1.9 KLF1 KLF17 ZIC2 ZNF335 E2F1 ZFHX2 GLIS2 POLR2A PATZ1 PRDM10 SCARA3 RNU6-1086P
GH08I027635 Enhancer 1.1 FANTOM5 Ensembl ENCODE 15.6 +3.3 3251 2.7 CTCF KLF1 CEBPB DPF2 ZNF121 CTBP1 ZNF692 ZNF341 HSF1 ZNF143 SCARA3 CLU STMN4 CHRNA2 RNU6-1086P
GH08I027610 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 6.2 -19.8 -19793 8.1 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 CLU FZD3 SCARA3 GULOP MIR6843
GH08I027675 Enhancer 0.9 Ensembl ENCODE 14.5 +41.4 41433 0.6 SOX13 CTCF SAP130 ARID4B MAX ZNF48 RAD21 RARA TEAD3 NR2F6 SCARA3 CCDC25 CLU RNU6-1086P
GH08I027771 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 4.7 +139.7 139681 4 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CCDC25 ESCO2 RNU6-1276P GC08P027774 CLU ELP3 SCARA3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SCARA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCARA3 gene promoter:

Genomic Locations for SCARA3 Gene

Genomic Locations for SCARA3 Gene
chr8:27,633,868-27,712,743
(GRCh38/hg38)
Size:
78,876 bases
Orientation:
Plus strand
chr8:27,491,385-27,534,293
(GRCh37/hg19)

Genomic View for SCARA3 Gene

Genes around SCARA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCARA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCARA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARA3 Gene

Proteins for SCARA3 Gene

  • Protein details for SCARA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AZY7-SCAR3_HUMAN
    Recommended name:
    Scavenger receptor class A member 3
    Protein Accession:
    Q6AZY7
    Secondary Accessions:
    • Q9UM15
    • Q9UM16

    Protein attributes for SCARA3 Gene

    Size:
    606 amino acids
    Molecular mass:
    65137 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCARA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCARA3 Gene

Post-translational modifications for SCARA3 Gene

  • Glycosylation at posLast=115115, posLast=182182, posLast=224224, isoforms=2257, posLast=313313, posLast=337337, posLast=365365, posLast=400400, isoforms=2430, and posLast=451451

Other Protein References for SCARA3 Gene

No data available for DME Specific Peptides for SCARA3 Gene

Domains & Families for SCARA3 Gene

Gene Families for SCARA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SCARA3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCARA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SCARA3: view

No data available for UniProtKB/Swiss-Prot for SCARA3 Gene

Function for SCARA3 Gene

Molecular function for SCARA3 Gene

UniProtKB/Swiss-Prot Function:
Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.

Phenotypes From GWAS Catalog for SCARA3 Gene

Gene Ontology (GO) - Molecular Function for SCARA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity TAS 9580669
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SCARA3: view
genes like me logo Genes that share phenotypes with SCARA3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCARA3 Gene

Localization for SCARA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARA3 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Endoplasmic reticulum and/or Golgi.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCARA3 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
plasma membrane 2
nucleus 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCARA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005581 collagen trimer IEA --
GO:0005783 endoplasmic reticulum IDA,IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with SCARA3: view

Pathways & Interactions for SCARA3 Gene

SuperPathways for SCARA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCARA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006979 response to oxidative stress TAS 9580669
GO:0009650 UV protection TAS 9580669
GO:0034138 NOT toll-like receptor 3 signaling pathway IMP 25204797
genes like me logo Genes that share ontologies with SCARA3: view

No data available for Pathways by source and SIGNOR curated interactions for SCARA3 Gene

Drugs & Compounds for SCARA3 Gene

No Compound Related Data Available

Transcripts for SCARA3 Gene

Unigene Clusters for SCARA3 Gene

Scavenger receptor class A, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCARA3 Gene

No ASD Table

Relevant External Links for SCARA3 Gene

GeneLoc Exon Structure for
SCARA3
ECgene alternative splicing isoforms for
SCARA3

Expression for SCARA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCARA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCARA3 Gene

This gene is overexpressed in Uterus (51.6) and Placenta (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCARA3 Gene



Protein tissue co-expression partners for SCARA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCARA3 Gene:

SCARA3

SOURCE GeneReport for Unigene cluster for SCARA3 Gene:

Hs.128856

mRNA Expression by UniProt/SwissProt for SCARA3 Gene:

Q6AZY7-SCAR3_HUMAN
Tissue specificity: Expressed ubiquitously.

Evidence on tissue expression from TISSUES for SCARA3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SCARA3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCARA3 Gene

Orthologs for SCARA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCARA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCARA3 33 34
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia SCARA3 33 34
  • 90.18 (n)
cow
(Bos Taurus)
Mammalia SCARA3 33 34
  • 88.39 (n)
mouse
(Mus musculus)
Mammalia Scara3 33 16 34
  • 86.8 (n)
rat
(Rattus norvegicus)
Mammalia Scara3 33
  • 86.25 (n)
oppossum
(Monodelphis domestica)
Mammalia SCARA3 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCARA3 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCARA3 33 34
  • 70.65 (n)
lizard
(Anolis carolinensis)
Reptilia SCARA3 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scara3 33
  • 64.87 (n)
zebrafish
(Danio rerio)
Actinopterygii scara3 33 34
  • 55.25 (n)
worm
(Caenorhabditis elegans)
Secernentea col-89 34
  • 25 (a)
ManyToMany
col-150 34
  • 25 (a)
ManyToMany
col-148 34
  • 25 (a)
ManyToMany
col-61 34
  • 24 (a)
ManyToMany
col-176 34
  • 24 (a)
ManyToMany
col-145 34
  • 24 (a)
ManyToMany
col-144 34
  • 24 (a)
ManyToMany
col-127 34
  • 24 (a)
ManyToMany
col-126 34
  • 24 (a)
ManyToMany
col-10 34
  • 24 (a)
ManyToMany
col-187 34
  • 23 (a)
ManyToMany
col-149 34
  • 23 (a)
ManyToMany
col-118 34
  • 23 (a)
ManyToMany
col-177 34
  • 17 (a)
ManyToMany
Species where no ortholog for SCARA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCARA3 Gene

ENSEMBL:
Gene Tree for SCARA3 (if available)
TreeFam:
Gene Tree for SCARA3 (if available)

Paralogs for SCARA3 Gene

Paralogs for SCARA3 Gene

(1) SIMAP similar genes for SCARA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCARA3: view

Variants for SCARA3 Gene

Sequence variations from dbSNP and Humsavar for SCARA3 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000009761 -- 27,729,011(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000013473 -- 27,644,787(+) G/T intron_variant
rs1000038334 -- 27,690,858(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000080967 -- 27,650,238(+) G/A intron_variant
rs1000111479 -- 27,719,536(+) T/C/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SCARA3 Gene

Variant ID Type Subtype PubMed ID
dgv3798n106 CNV deletion 24896259
dgv3799n106 CNV tandem duplication 24896259
esv2736798 CNV deletion 23290073
esv3616725 CNV loss 21293372
nsv397633 CNV deletion 16902084
nsv610867 CNV gain 21841781

Variation tolerance for SCARA3 Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCARA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCARA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCARA3 Gene

Disorders for SCARA3 Gene

Additional Disease Information for SCARA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SCARA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCARA3 Gene

Publications for SCARA3 Gene

  1. CSR, a scavenger receptor-like protein with a protective role against cellular damage causedby UV irradiation and oxidative stress. (PMID: 9580669) Han HJ … Nakamura Y (Human molecular genetics 1998) 2 3 4 22 58
  2. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Dinucleotide repeat polymorphism in the first intron of the CSR gene. (PMID: 9747040) Han HJ … Nakamura Y (Journal of human genetics 1998) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SCARA3 Gene

Sources for SCARA3 Gene

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