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SCARA3 Gene

protein-coding   GIFtS: 54
GCID: GC08P027492

Scavenger Receptor Class A, Member 3

  See SCARA3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Scavenger Receptor Class A, Member 31 2     APC72
CSR2 3 5     CSR12
Macrophage Scavenger Receptor-Like 11 2     MSRL12
Cellular Stress Response Gene Protein2 3     Cellular Stress Response Protein2
MSLR12 5     Scavenger Receptor Class A Member 32

External Ids:    HGNC: 190001   Entrez Gene: 514352   Ensembl: ENSG000001680777   OMIM: 6027285   UniProtKB: Q6AZY73   

Export aliases for SCARA3 gene to outside databases

Previous GC identifers: GC08P027274 GC08P027996 GC08P027513 GC08P027547 GC08P026036


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCARA3 Gene:
This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive
oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this
gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have
been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for SCARA3 Gene:
SCARA3 (scavenger receptor class A, member 3) is a protein-coding gene. Diseases associated with SCARA3 include triple-a syndrome. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is COL28A1.

UniProtKB/Swiss-Prot: SCAR3_HUMAN, Q6AZY7
Function: Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCARA3 gene promoter:
         PPAR-alpha   AP-1   ATF-2   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCARA3 promoter sequence
   Search Chromatin IP Primers for SCARA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCARA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21

SCARA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCARA3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P027492:  view genomic region     (about GC identifiers)

Start:
27,491,385 bp from pter      End:
27,534,293 bp from pter
Size:
42,909 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SCAR3_HUMAN, Q6AZY7 (See protein sequence)
Recommended Name: Scavenger receptor class A member 3  
Size: 606 amino acids; 65137 Da
Secondary accessions: Q9UM15 Q9UM16
Alternative splicing: 2 isoforms:  Q6AZY7-1   Q6AZY7-2   

Explore the universe of human proteins at neXtProt for SCARA3: NX_Q6AZY7

Explore proteomics data for SCARA3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn115, Asn182, Asn224, Asn257, Asn313, Asn337, Asn365, Asn400, Asn430, Asn451
  • Modification sites at PhosphoSitePlus

  • See SCARA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_057324.2  NP_878185.1  

    ENSEMBL proteins: 
     ENSP00000337985   ENSP00000301904  

    SCARA3 Human Recombinant Protein Products:

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    Novus Biologicals SCARA3 Protein
    Novus Biologicals SCARA3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCARA3

     
    Search eBioscience for Proteins for SCARA3 

     
    antibodies-online proteins for SCARA3 (2 products) 

     
    antibodies-online peptides for SCARA3

    SCARA3 Antibody Products:

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    antibodies-online antibodies for SCARA3 (16 products) 

    SCARA3 Assay Products:

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    Cloud-Clone Corp. ELISAs for SCARA3
    Cloud-Clone Corp. CLIAs for SCARA3
    Search eBioscience for ELISAs for SCARA3 
    antibodies-online kits for SCARA3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q6AZY7

    ProtoNet protein and cluster: Q6AZY7

    1 Blocks protein domain: IPB008160 Collagen triple helix repeat

    UniProtKB/Swiss-Prot: SCAR3_HUMAN, Q6AZY7
    Similarity: Contains 2 collagen-like domains


    Find genes that share domains with SCARA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCAR3_HUMAN, Q6AZY7
    Function: Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044scavenger receptor activity TAS9580669
         
    Find genes that share ontologies with SCARA3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SCARA3:
     Decreased circadian period len 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SCARA3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SCARA3:
    hsa-mir-26b-5p (MIRT030128), hsa-mir-615-3p (MIRT040380)

    Block miRNA regulation of human, mouse, rat SCARA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCARA3 (see all 32):
    hsa-miR-3130-5p hsa-miR-3685 hsa-miR-429 hsa-let-7d hsa-miR-513a-5p hsa-miR-301a hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidSCARA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SCARA3
    Predesigned siRNA for gene silencing in human, mouse, rat SCARA3

    Gene Editing
    Products:
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCARA3

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCARA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCAR3_HUMAN, Q6AZY7: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus
    membrane; Single-pass type II membrane protein. Note=Endoplasmic reticulum and/or Golgi
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    extracellular3
    nucleus2
    plasma membrane2
    chloroplast1
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005581collagen IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SCARA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including SCARA3: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SCARA3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SCARA3 (Q6AZY73 ENSP000003019044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT7Q9UIV13I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS9580669
    GO:0006979response to oxidative stress TAS9580669
    GO:0009650UV protection TAS9580669

    Find genes that share ontologies with SCARA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCARA3 (SCAR3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCARA3 gene (2 alternative transcripts): 
    NM_016240.2  NM_182826.1  

    Unigene Cluster for SCARA3:

    Scavenger receptor class A, member 3
    Hs.128856  [show with all ESTs]
    Unigene Representative Sequence: AB007829
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337221(uc003xgb.1) ENST00000301904(uc003xga.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCARA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCARA3 (see all 32):
    hsa-miR-3130-5p hsa-miR-3685 hsa-miR-429 hsa-let-7d hsa-miR-513a-5p hsa-miR-301a hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidSCARA3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SCARA3
    Predesigned siRNA for gene silencing in human, mouse, rat SCARA3
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    GenScript: all cDNA clones in your preferred vector (see all 2): SCARA3 (NM_182826)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCARA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCARA3
    Primer
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    OriGene qPCR primer pairs and template standards for SCARA3
    OriGene qSTAR qPCR primer pairs in human, mouse for SCARA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCARA3
      QuantiTect SYBR Green Assays in human, mouse, rat SCARA3
      QuantiFast Probe-based Assays in human, mouse, rat SCARA3

    Additional mRNA sequence: 

    AB007829.1 AB007830.1 BC060811.1 BC075067.3 BC075068.2 

    5 DOTS entries:

    DT.75187797  DT.102827280  DT.95311606  DT.40124323  DT.75130925 

    Selected AceView cDNA sequences (see all 92):

    BQ019067 AI368657 AW167789 NM_016240 AI129622 AI379041 BQ181608 CA420827 
    NM_182826 BC075067 AI452447 BM422394 BC060811 BX952687 CN483332 AA708619 
    AB007830 BC075068 AI573247 BX092946 BM723549 AA826654 BF928803 BQ180959 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCARA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTCTCCT
    SCARA3 Expression
    About this image


    SCARA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Notochord Cells Notochord
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
    SCARA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCARA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128856

    UniProtKB/Swiss-Prot: SCAR3_HUMAN, Q6AZY7
    Tissue specificity: Expressed ubiquitously

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SCARA3: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCARA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SCARA3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scara31 , 5 scavenger receptor class A, member 31, 5 86.8(n)1
    90.76(a)1
      14 (34.36 cM)5
    2191511  NM_172604.31  NP_766192.11 
     659193955 
    chicken
    (Gallus gallus)
    Aves SCARA31 scavenger receptor class A, member 3 70.65(n)
    66.26(a)
      771117  XM_001234415.2  XP_001234416.2 
    lizard
    (Anolis carolinensis)
    Reptilia SCARA36
    scavenger receptor class A, member 3
    65(a)
    1 ↔ 1
    GL344029.1(63922-92771)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia scara31 scavenger receptor class A, member 3 64.87(n)
    63.41(a)
      100494707  XM_002938177.2  XP_002938223.2 
    zebrafish
    (Danio rerio)
    Actinopterygii scara31 scavenger receptor class A, member 3 55.25(n)
    47.49(a)
      564588  XM_687918.5  XP_693010.5 
    worm
    (Caenorhabditis elegans)
    Secernentea col-1486
    col-1506
    (see all 14)
    Protein COL-150 (col-150) mRNA, complete cds
    (see all 14)
    25(a)
    25(a)
    (see all 14)
    many ↔ many
    many ↔ many
    (see all 14)
    V(10241784-10242718) WBGene00000721
    V(10293565-10294621) WBGene00000723


    ENSEMBL Gene Tree for SCARA3 (if available)
    TreeFam Gene Tree for SCARA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCARA3 gene
    COL28A12  COL6A12  COLEC122  COL6A52  COLQ2  COL6A62  COL6A22  COL17A12  
    COL6A32  
    1 SIMAP similar gene for SCARA3 using alignment to 1 protein entry:     SCAR3_HUMAN:
    COLEC12

    Find genes that share paralogs with SCARA3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCARA3 (see all 1139)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340913101,2
    C,F--26051340(+) AGATAAAGA/-  
            
    GAGAG
    2 -- int15Minor allele frequency- -:0.13NS 182
    rs1455490541,2
    --27489676(+) GTATAA/GTCTGG 2 -- us2k10--------
    rs343477321,2
    C,F--27489731(+) TTTTTT/-GTTTT 2 -- us2k110Minor allele frequency- -:0.50NS 364
    rs1861005091,2
    --27489733(+) TGAGTA/TTTTTT 2 -- us2k10--------
    rs1489059791,2
    --27489777(+) ATGAAA/GCTGAA 2 -- us2k10--------
    rs1890126671,2
    --27489849(+) GGCCAC/TCATGG 2 -- us2k10--------
    rs1820577071,2
    --27489878(+) TTTTTC/TAGGAA 2 -- us2k10--------
    rs4859021,2
    C,F,H--27489959(-) gaaagC/Gccacc 2 -- us2k115Minor allele frequency- G:0.34EA NS NA CSA WA 846
    rs351233861,2
    C,F--27490058(+) GACTAC/TATTGG 2 -- us2k15Minor allele frequency- T:0.00NS 182
    rs357756261,2
    C,F,H--27490111(+) GCCTTT/CCCCCA 2 -- us2k121Minor allele frequency- C:0.15NS EA NA WA 2518

    HapMap Linkage Disequilibrium report for SCARA3 (27491385 - 27534293 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SCARA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736798CNV Deletion23290073
    nsv397633CNV Loss16902084
    nsv890698CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCARA3
    DNA2.0 Custom Variant and Variant Library Synthesis for SCARA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602728    OMIM disorders: --

    1 disease for SCARA3:    
    About MalaCards
    triple-a syndrome

    2 diseases from the University of Copenhagen DISEASES database for SCARA3:
    Peritoneal carcinoma     triple-A syndrome

    Find genes that share disorders with SCARA3           About GenesLikeMe

    Genetic Association Database (GAD): SCARA3
    Human Genome Epidemiology (HuGE) Navigator: SCARA3 (1 document)

    Export disorders for SCARA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCARA3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SCARA3)
        Utopia: connect your pdf to the dynamic
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    1. CSR, a scavenger receptor-like protein with a protective role against cellular damage caused by UV irradiation and oxidative stress. (PubMed id 9580669)1, 2, 3, 9 Han H.-J.... Nakamura Y. (Hum. Mol. Genet. 1998)
    2. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Dinucleotide repeat polymorphism in the first intron of the CSR gene. (PubMed id 9747040)1, 3 Han H.J. and Nakamura Y. (J. Hum. Genet. 1998)
    5. Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma. (PubMed id 23537707)1 Brown C.O....Goel A. (Leuk. Res. 2013)
    6. Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides. (PubMed id 22138034)1 Ezzat K....Langel U. (FASEB J. 2012)
    7. SCARA3 mRNA is overexpressed in ovarian carcinoma compared with breast carcinoma effusions. (PubMed id 21855113)1 Bock A.J....KA ( 2012)
    8. Interaction of CSR1 with XIAP reverses inhibition of caspases and accelerates cell death. (PubMed id 22683311)1 Zheng Z.L....Luo J.H. (Am. J. Pathol. 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51435 HGNC: 19000 AceView: SCARA3 Ensembl:ENSG00000168077 euGenes: HUgn51435
    ECgene: SCARA3 H-InvDB: SCARA3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SCARA3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/scara3/

    (Patent information from GeneIP,
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    Patent Information for SCARA3 gene:
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