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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCAPER Gene

protein-coding   GIFtS: 47
GCID: GC15M076640

S-Phase Cyclin A-Associated Protein In The ER

(Previous name: zinc finger protein 291)
(Previous symbol: ZNF291)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
S-Phase Cyclin A-Associated Protein In The ER1 2     KIAA14543 5
Zinc Finger Protein 2911 2 3     Zfp2912
ZNF2911 2 3     S Phase Cyclin A-Associated Protein In The Endoplasmic Reticulum2
S Phase Cyclin A-Associated Protein In The ER2 3     

External Ids:    HGNC: 130811   Entrez Gene: 498552   Ensembl: ENSG000001403867   OMIM: 6116115   UniProtKB: Q9BY123   

Export aliases for SCAPER gene to outside databases

Previous GC identifers: GC15M074428 GC15M053397


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SCAPER Gene: 
SCAPER (S-phase cyclin A-associated protein in the ER) is a protein-coding gene. Diseases associated with SCAPER include composite lymphoma, and fanconi's anemia. GO annotations related to this gene include zinc ion binding.

UniProtKB/Swiss-Prot: SCAPE_HUMAN, Q9BY12
Function: CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SCAPER gene promoter:
         MEF-2A   RORalpha1   aMEF-2   ZID   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCAPER promoter sequence
   Search SABiosciences Chromatin IP Primers for SCAPER

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAPER


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q24.3   HGNC cytogenetic band: 15q24.3

SCAPER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCAPER gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M076640:  view genomic region     (about GC identifiers)

Start:
76,640,526 bp from pter      End:
77,197,785 bp from pter
Size:
557,260 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SCAPE_HUMAN, Q9BY12 (See protein sequence)
Recommended Name: S phase cyclin A-associated protein in the endoplasmic reticulum  
Size: 1400 amino acids; 158287 Da
Subunit: Interacts with CCNA2/CDK2 complex, but not with CCNA2/CDC2, CCNB1/CDC2 or CCNE1/CDK2 complexes, at
multiple phases of the cell cycle, including S and G2/M
Subcellular location: Endoplasmic reticulum. Nucleus. Note=Predominantly located in the endoplasmic reticulum,
only a small portion is detected in the nucleus
Developmental stage: Expressed at each stage of the cell cycle, including G0, although the expression is somewhat
higher in late G1 and S phases
Sequence caution: Sequence=AAG47945.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH15212.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI07416.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAK29205.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: F5H7X8 H3BNR7 Q3B7X7 Q96BS9 Q9H3D8 Q9NT03 Q9P274
Alternative splicing: 3 isoforms:  Q9BY12-1   Q9BY12-2   Q9BY12-3   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCAPER: NX_Q9BY12

Explore proteomics data for SCAPER at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in vitro by the CCNA2/CDK2 complex
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BY12

  • SCAPER Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCAPER Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001139395.1  NP_065894.2  

    ENSEMBL proteins: 
     ENSP00000442190   ENSP00000454973   ENSP00000457234   ENSP00000455623   ENSP00000456508  
     ENSP00000455378   ENSP00000456987   ENSP00000457434   ENSP00000456065   ENSP00000455751  
     ENSP00000457382   ENSP00000455231   ENSP00000326924  

    Human Recombinant Protein Products for SCAPER: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SCAPER
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SCAPER
    GenScript Custom Purified and Recombinant Proteins Services for SCAPER
    Novus Biologicals SCAPER Protein
    Novus Biologicals SCAPER Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCAPER 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--

    SCAPER for ontologies           About GeneDecksing



    SCAPER Antibody Products: 
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    Novus Biologicals SCAPER Antibodies
    Abcam antibodies for SCAPER
    Cloud-Clone Corp. Antibodies for SCAPER 
    Search ThermoFisher Antibodies for SCAPER
    LSBio Antibodies in human, mouse, rat for SCAPER 

    Assay Products for SCAPER: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCAPER
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCAPER 
    Cloud-Clone Corp. CLIAs for SCAPER


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    1 InterPro protein domain:
     IPR015880 Znf_C2H2-like

    Graphical View of Domain Structure for InterPro Entry Q9BY12

    ProtoNet protein and cluster: Q9BY12

    UniProtKB/Swiss-Prot: SCAPE_HUMAN, Q9BY12
    Similarity: Contains 1 C2H2-type zinc finger


    SCAPER for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCAPE_HUMAN, Q9BY12
    Function: CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    SCAPER for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCAPER 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SCAPER

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCAPER 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCAPER 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCAPER
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SCAPER:
    hsa-miR-3121-3p hsa-miR-139-5p hsa-miR-556-3p hsa-miR-340 hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidSCAPER 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCAPER
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCAPER

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCAPER
    Sirion Biotech Customized adenovirus for overexpression of SCAPER

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SCAPER (see all 14)
    OriGene ORF clones in mouse, rat for SCAPER
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCAPER (NM_001145923)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCAPER
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAPER
    Sirion Biotech Customized lentivirus for stable overexpression of SCAPER 
                         Customized lentivirus expression plasmids for stable overexpression of SCAPER 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SCAPER
    Search LifeMap BioReagents cell lines for SCAPER
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAPER


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCAPER

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for SCAPER (Q9BY123 ENSP000003269244) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    CELSR3Q9NYQ73, ENSP000001640244I2D: score=3 STRING: ENSP00000164024
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCAPER (SCAPE)

    Search CenterWatch for drugs/clinical trials and news about SCAPER / SCAPE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCAPER gene (2 alternative transcripts): 
    NM_001145923.1  NM_020843.2  

    Unigene Cluster for SCAPER:

    S-phase cyclin A-associated protein in the ER
    Hs.458986  [show with all ESTs]
    Unigene Representative Sequence: NM_001145923
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000538941(uc002bbx.3) ENST00000563290(uc010bkr.3 uc002bby.3 uc002bca.1 uc002bcb.1)
    ENST00000562948 ENST00000563246 ENST00000303521(uc002bbz.1) ENST00000567601
    ENST00000569395 ENST00000568428 ENST00000564757 ENST00000563688 ENST00000569784
    ENST00000565507 ENST00000564590(uc002bcc.1) ENST00000565970 ENST00000564022
    ENST00000568549 ENST00000567618 ENST00000562890
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SCAPER
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SCAPER:
    hsa-miR-3121-3p hsa-miR-139-5p hsa-miR-556-3p hsa-miR-340 hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidSCAPER 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SCAPER
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCAPER
    Clone
    Products:
         
    OriGene clones in human, mouse for SCAPER (see all 14)
    OriGene ORF clones in mouse, rat for SCAPER
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCAPER (NM_001145923)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCAPER
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAPER
    Sirion Biotech Customized lentivirus for stable overexpression of SCAPER 
                         Customized lentivirus expression plasmids for stable overexpression of SCAPER 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SCAPER
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCAPER
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCAPER
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCAPER

    Additional mRNA sequence: 

    AF119814.1 AF242528.1 AK025663.1 AK056095.1 AK056515.1 AL137612.1 BC015212.1 BC070197.1 
    BC107415.1 BT006762.1 BX647285.1 

    24 DOTS entries:

    DT.310989  DT.100795262  DT.99948034  DT.100795259  DT.95374417  DT.92429300  DT.121028373  DT.121028400 
    DT.101966812  DT.121028389  DT.92415830  DT.100036009  DT.100730100  DT.121028388  DT.121028414  DT.121028449 
    DT.121028450  DT.121028460  DT.40114195  DT.92429301  DT.95374419  DT.100795265  DT.75174778  DT.97802990 

    24/144 AceView cDNA sequences (see all 144):

    BX647285 BU618222 AI357867 BM670902 AI659321 AF242528 CK822099 AK128091 
    BQ639700 BM693840 AA383215 AK056095 BX484434 AV706820 BG251026 BC015212 
    BP351689 BP368337 CR590728 BX100838 CD630440 AL137612 BT006762 NM_020843 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCAPER expression in normal human tissues (normalized intensities)      SCAPER embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAGGAAAT
    SCAPER Expression
    About this image


    SCAPER expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             superior temporal gyrus   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             retina   
     
     Ovary (Reproductive System)
             oocyte   
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
     
     Limb (Muscoskeletal System)

    See SCAPER Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCAPER

    SOURCE GeneReport for Unigene cluster: Hs.458986

    UniProtKB/Swiss-Prot: SCAPE_HUMAN, Q9BY12
    Tissue specificity: Widely expressed with highest expression in testis

        SABiosciences Custom PCR Arrays for SCAPER
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCAPER
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCAPER
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAPER

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SCAPER gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scaper1 , 5 S phase cyclin A-associated protein in the ER1, 5 87.94(n)1
    88.71(a)1
      9 (30.13 cM)5
    2448911  NM_001081341.11  NP_001074810.11 
     555498835 
    chicken
    (Gallus gallus)
    Aves SCAPER1 S-phase cyclin A-associated protein in the ER 75.68(n)
    78.83(a)
      415352  XM_413736.3  XP_413736.3 
    lizard
    (Anolis carolinensis)
    Reptilia SCAPER6
    S-phase cyclin A-associated protein in the ER
    78(a)
    1 ↔ 1
    GL343374.1(970669-1076960)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162992 Xenopus laevis transcribed sequence with strong similarity more 76.83(n)    BJ047205.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scaper1 S phase cyclin A-associated protein in the ER 68.58(n)
    75.71(a)
      100144551  NM_001123047.1  NP_001116519.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ssp36
    short spindle 3
    20(a)
    1 ↔ 1
    2L(18916525-18943948)
    worm
    (Caenorhabditis elegans)
    Secernentea Y6B3B.46
    Protein Y6B3B.4
    18(a)
    1 ↔ 1
    I(13756737-13771773)


    ENSEMBL Gene Tree for SCAPER (if available)
    TreeFam Gene Tree for SCAPER (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCAPER gene

    SCAPER for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SCAPER
    PGOHUM00000259004


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9579 SNPs in SCAPER are shown (see all 9579)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725340601,2
    C--53737356(+) CATCA-/ATTGTTT 2 -- int10--------
    rs360725611,2
    C--56857077(+) TTTCC-/A/AG  
            
    AAAAA
    2 -- int10--------
    rs345034821,2
    C--57122179(+) AAAAAA/-TGTAC 2 -- int11Minor allele frequency- -:0.00NA 2
    rs802489071,2
    F--76640078(+) TGTTTG/CATCAG 2 -- int11Minor allele frequency- C:0.04WA 118
    rs24695531,2
    C,H--76640162(+) ATGAGA/GACAAG 2 -- int112Minor allele frequency- G:0.06NA WA CSA EA 374
    rs1424247101,2
    --76640395(+) ATTATC/TTGCTA 2 -- int10--------
    rs24601611,2
    C,F,A,H--76640430(+) TACAAC/TGCCCT 2 -- int119Minor allele frequency- T:0.13NS EA NA CSA WA 2344
    rs24692251,2
    C,F,A,H--76640658(-) TTCTTG/ATAATA 2 -- ut3110Minor allele frequency- A:0.09NS NA WA 1434
    rs1850210261,2
    --76640729(+) TTATCA/GTAAGA 2 -- ut310--------
    rs2003188101,2
    C--76640735(-) TTTCCA/GTCTTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SCAPER (76640526 - 76890526 bp, first 250kb of SCAPER)

    Structural Variations
         Database of Genomic Variants (DGV) 10/42 variations for SCAPER (see all 42):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv460e199CNV Deletion23128226
    esv1002951CNV Deletion20482838
    esv2749895CNV Deletion23290073
    esv2662931CNV Deletion23128226
    esv2749898CNV Deletion23290073
    esv2660976CNV Deletion23128226
    esv2659496CNV Deletion23128226
    nsv820890CNV Deletion20802225
    esv2421572CNV Deletion20811451
    esv270942CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SCAPER
    DNA2.0 Custom Variant and Variant Library Synthesis for SCAPER

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611611    OMIM disorders: --

    3 diseases for SCAPER:    About MalaCards
    composite lymphoma    fanconi's anemia    anemia

    1 disease from the University of Copenhagen DISEASES database for SCAPER:
    Composite lymphoma

    SCAPER for disorders           About GeneDecksing

    Genetic Association Database (GAD): SCAPER

    Export disorders for SCAPER gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCAPER gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SCAPER)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. (PubMed id 17698606)1, 2, 3 Tsang W.Y....Dynlacht B.D. (2007)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Proteomics analysis of nucleolar SUMO-1 target protei ns upon proteasome inhibition. (PubMed id 19596686)1 Matafora V....Bachi A. (2009)
    6. Double identity of SCAPER: a substrate and regulator of cyclin A/Cdk2. (PubMed id 18245951)1 Tsang W.Y. and Dynlacht B.D. (2008)
    7. Detection of an unstable non-coding tandem repeat in the ZNF291 gene. (PubMed id 17553665)1 Laura V....Annalisa B. (2007)
    8. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 49855 HGNC: 13081 AceView: ZNF291 Ensembl:ENSG00000140386 euGenes: HUgn49855
    ECgene: SCAPER H-InvDB: SCAPER

    (According to HUGE)
    About This Section
    HUGE: KIAA1454

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCAPER Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCAPER gene:
    Search GeneIP for patents involving SCAPER

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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