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Aliases for SCAPER Gene

Aliases for SCAPER Gene

  • S-Phase Cyclin A-Associated Protein In The ER 2 3 5
  • Zinc Finger Protein 291 2 3 4
  • S Phase Cyclin A-Associated Protein In The ER 3 4
  • ZNF291 3 4
  • KIAA1454 4
  • MSTP063 3
  • Zfp291 3

External Ids for SCAPER Gene

Previous HGNC Symbols for SCAPER Gene

  • ZNF291

Previous GeneCards Identifiers for SCAPER Gene

  • GC15M074428
  • GC15M076640
  • GC15M053397

Summaries for SCAPER Gene

GeneCards Summary for SCAPER Gene

SCAPER (S-Phase Cyclin A-Associated Protein In The ER) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SCAPER Gene

  • CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAPER Gene

Genomics for SCAPER Gene

Regulatory Elements for SCAPER Gene

Promoters for SCAPER Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCAPER on UCSC Golden Path with GeneCards custom track

Genomic Location for SCAPER Gene

Chromosome:
15
Start:
76,347,904 bp from pter
End:
76,905,455 bp from pter
Size:
557,552 bases
Orientation:
Minus strand

Genomic View for SCAPER Gene

Genes around SCAPER on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAPER Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAPER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAPER Gene

Proteins for SCAPER Gene

  • Protein details for SCAPER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY12-SCAPE_HUMAN
    Recommended name:
    S phase cyclin A-associated protein in the endoplasmic reticulum
    Protein Accession:
    Q9BY12
    Secondary Accessions:
    • F5H7X8
    • H3BNR7
    • Q3B7X7
    • Q96BS9
    • Q9H3D8
    • Q9NT03
    • Q9P274

    Protein attributes for SCAPER Gene

    Size:
    1400 amino acids
    Molecular mass:
    158287 Da
    Quaternary structure:
    • Interacts with CCNA2/CDK2 complex, but not with CCNA2/CDC2, CCNB1/CDC2 or CCNE1/CDK2 complexes, at multiple phases of the cell cycle, including S and G2/M.
    SequenceCaution:
    • Sequence=AAG47945.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15212.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI07416.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAK29205.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SCAPER Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAPER Gene

Proteomics data for SCAPER Gene at MOPED

Post-translational modifications for SCAPER Gene

  • Phosphorylated in vitro by the CCNA2/CDK2 complex.
  • Ubiquitination at Lys 928 and Lys 1368
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SCAPER

No data available for DME Specific Peptides for SCAPER Gene

Domains & Families for SCAPER Gene

Gene Families for SCAPER Gene

Protein Domains for SCAPER Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAPER Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY12

UniProtKB/Swiss-Prot:

SCAPE_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with SCAPER: view

Function for SCAPER Gene

Molecular function for SCAPER Gene

UniProtKB/Swiss-Prot Function:
CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.

Phenotypes for SCAPER Gene

genes like me logo Genes that share phenotypes with SCAPER: view

Animal Model Products

miRNA for SCAPER Gene

miRTarBase miRNAs that target SCAPER

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAPER Gene

Localization for SCAPER Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAPER Gene

Endoplasmic reticulum. Nucleus. Note=Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCAPER Gene COMPARTMENTS Subcellular localization image for SCAPER gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SCAPER Gene

Pathways & Interactions for SCAPER Gene

SuperPathways for SCAPER Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAPER Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCAPER Gene

Drugs & Compounds for SCAPER Gene

No Compound Related Data Available

Transcripts for SCAPER Gene

Unigene Clusters for SCAPER Gene

S-phase cyclin A-associated protein in the ER:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCAPER Gene

No ASD Table

Relevant External Links for SCAPER Gene

GeneLoc Exon Structure for
SCAPER
ECgene alternative splicing isoforms for
SCAPER

Expression for SCAPER Gene

mRNA expression in normal human tissues for SCAPER Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCAPER Gene

This gene is overexpressed in Fetal Brain (23.7), Testis (18.2), Heart (6.4), Ovary (6.3), and Bone marrow mesenchymal stem cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAPER Gene



SOURCE GeneReport for Unigene cluster for SCAPER Gene Hs.458986

mRNA Expression by UniProt/SwissProt for SCAPER Gene

Q9BY12-SCAPE_HUMAN
Tissue specificity: Widely expressed with highest expression in testis.
genes like me logo Genes that share expression patterns with SCAPER: view

Protein tissue co-expression partners for SCAPER Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SCAPER Gene

Orthologs for SCAPER Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAPER Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCAPER 35
  • 92.53 (n)
  • 92.84 (a)
SCAPER 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCAPER 35
  • 90.87 (n)
  • 90.85 (a)
SCAPER 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scaper 35
  • 87.94 (n)
  • 88.71 (a)
Scaper 16
Scaper 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCAPER 35
  • 99.74 (n)
  • 99.57 (a)
SCAPER 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCAPER 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves SCAPER 35
  • 75.6 (n)
  • 78.64 (a)
SCAPER 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAPER 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scaper 35
  • 69.55 (n)
  • 73.07 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16299 35
zebrafish
(Danio rerio)
Actinopterygii scaper 35
  • 67.66 (n)
  • 73.69 (a)
scaper 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ssp3 36
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y6B3B.4 36
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3404 36
  • 33 (a)
OneToOne
Species with no ortholog for SCAPER:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAPER Gene

ENSEMBL:
Gene Tree for SCAPER (if available)
TreeFam:
Gene Tree for SCAPER (if available)

Paralogs for SCAPER Gene

Pseudogenes.org Pseudogenes for SCAPER Gene

genes like me logo Genes that share paralogs with SCAPER: view

No data available for Paralogs for SCAPER Gene

Variants for SCAPER Gene

Sequence variations from dbSNP and Humsavar for SCAPER Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1607017 - 76,434,124(-) ACAAA(A/C)CCTCA reference, missense
rs3743176 -, - 76,404,573(+) TCCTG(C/T)GGCAT intron-variant, reference, missense
rs279991 -- 76,707,462(+) agata(C/T)ggcta intron-variant
rs279992 -- 76,700,431(+) ggtga(C/G)agtgg intron-variant
rs279993 -- 76,699,787(+) CAGGT(C/T)CAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAPER Gene

Variant ID Type Subtype PubMed ID
esv2749895 CNV Deletion 23290073
esv2749898 CNV Deletion 23290073
nsv904399 CNV Loss 21882294
nsv525769 CNV Loss 19592680
nsv510667 CNV Loss 20534489
nsv507790 CNV Insertion 20534489
esv273470 CNV Insertion 20981092
esv2662931 CNV Deletion 23128226
esv2659496 CNV Deletion 23128226
dgv2417n71 CNV Loss 21882294
nsv471254 CNV Loss 18288195
esv270942 CNV Insertion 20981092
nsv1620 CNV Loss 18451855
nsv904402 CNV Gain 21882294
nsv904403 CNV Loss 21882294
dgv2418n71 CNV Loss 21882294
dgv2419n71 CNV Loss 21882294
dgv2420n71 CNV Gain 21882294
nsv510668 CNV Loss 20534489
nsv116 CNV Loss 15895083
esv1002951 CNV Deletion 20482838
dgv460e199 CNV Deletion 23128226
nsv820890 CNV Deletion 20802225
nsv827392 CNV Loss 20364138
esv33866 CNV Loss 17666407
esv24977 CNV Gain+Loss 19812545
nsv9278 CNV Gain+Loss 18304495
esv32734 CNV Gain+Loss 17666407
nsv820145 CNV Gain 19587683
dgv439n67 CNV Loss 20364138
nsv498853 CNV Loss 21111241
nsv507791 CNV Insertion 20534489
nsv511549 CNV Gain 21212237
esv2421572 CNV Deletion 20811451
nsv442706 CNV CNV 18776908
nsv514786 CNV Loss 21397061
nsv904413 CNV Loss 21882294
nsv457206 CNV Loss 19166990
esv2660976 CNV Deletion 23128226
esv267529 CNV Insertion 20981092
esv272422 CNV Insertion 20981092
dgv757e1 CNV Complex 17122850

Variation tolerance for SCAPER Gene

Residual Variation Intolerance Score: 7.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.61; 97.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCAPER Gene

HapMap Linkage Disequilibrium report
SCAPER

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAPER Gene

Disorders for SCAPER Gene

Relevant External Links for SCAPER

Genetic Association Database (GAD)
SCAPER
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCAPER

No disorders were found for SCAPER Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAPER Gene

Publications for SCAPER Gene

  1. SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. (PMID: 17698606) Tsang W.Y. … Dynlacht B.D. (J. Cell Biol. 2007) 2 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3

Products for SCAPER Gene

Sources for SCAPER Gene

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