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Aliases for SCAPER Gene

Aliases for SCAPER Gene

  • S-Phase Cyclin A Associated Protein In The ER 2 3 5
  • Zinc Finger Protein 291 2 3 4
  • S Phase Cyclin A-Associated Protein In The ER 3 4
  • ZNF291 3 4
  • S Phase Cyclin A-Associated Protein In The Endoplasmic Reticulum 3
  • KIAA1454 4
  • MSTP063 3
  • Zfp291 3

External Ids for SCAPER Gene

Previous HGNC Symbols for SCAPER Gene

  • ZNF291

Previous GeneCards Identifiers for SCAPER Gene

  • GC15M074428
  • GC15M076640
  • GC15M053397

Summaries for SCAPER Gene

GeneCards Summary for SCAPER Gene

SCAPER (S-Phase Cyclin A Associated Protein In The ER) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SCAPER Gene

  • CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAPER Gene

Genomics for SCAPER Gene

Regulatory Elements for SCAPER Gene

Enhancers for SCAPER Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SCAPER on UCSC Golden Path with GeneCards custom track

Promoters for SCAPER Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SCAPER Gene

Chromosome:
15
Start:
76,347,904 bp from pter
End:
76,905,455 bp from pter
Size:
557,552 bases
Orientation:
Minus strand

Genomic View for SCAPER Gene

Genes around SCAPER on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAPER Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAPER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAPER Gene

Proteins for SCAPER Gene

  • Protein details for SCAPER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY12-SCAPE_HUMAN
    Recommended name:
    S phase cyclin A-associated protein in the endoplasmic reticulum
    Protein Accession:
    Q9BY12
    Secondary Accessions:
    • F5H7X8
    • H3BNR7
    • Q3B7X7
    • Q96BS9
    • Q9H3D8
    • Q9NT03
    • Q9P274

    Protein attributes for SCAPER Gene

    Size:
    1400 amino acids
    Molecular mass:
    158287 Da
    Quaternary structure:
    • Interacts with CCNA2/CDK2 complex, but not with CCNA2/CDC2, CCNB1/CDC2 or CCNE1/CDK2 complexes, at multiple phases of the cell cycle, including S and G2/M.
    SequenceCaution:
    • Sequence=AAG47945.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15212.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI07416.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAK29205.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SCAPER Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAPER Gene

Post-translational modifications for SCAPER Gene

  • Phosphorylated in vitro by the CCNA2/CDK2 complex.
  • Ubiquitination at Lys 928 and Lys 1368
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCAPER Gene

Domains & Families for SCAPER Gene

Gene Families for SCAPER Gene

Protein Domains for SCAPER Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAPER Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY12

UniProtKB/Swiss-Prot:

SCAPE_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with SCAPER: view

Function for SCAPER Gene

Molecular function for SCAPER Gene

UniProtKB/Swiss-Prot Function:
CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.

Gene Ontology (GO) - Molecular Function for SCAPER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with SCAPER: view

Phenotypes for SCAPER Gene

genes like me logo Genes that share phenotypes with SCAPER: view

Animal Model Products

CRISPR Products

miRNA for SCAPER Gene

miRTarBase miRNAs that target SCAPER

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAPER Gene

Localization for SCAPER Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAPER Gene

Endoplasmic reticulum. Nucleus. Note=Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCAPER Gene COMPARTMENTS Subcellular localization image for SCAPER gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SCAPER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with SCAPER: view

Pathways & Interactions for SCAPER Gene

SuperPathways for SCAPER Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAPER Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCAPER Gene

Drugs & Compounds for SCAPER Gene

No Compound Related Data Available

Transcripts for SCAPER Gene

Unigene Clusters for SCAPER Gene

S-phase cyclin A-associated protein in the ER:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAPER Gene

No ASD Table

Relevant External Links for SCAPER Gene

GeneLoc Exon Structure for
SCAPER
ECgene alternative splicing isoforms for
SCAPER

Expression for SCAPER Gene

mRNA expression in normal human tissues for SCAPER Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCAPER Gene

This gene is overexpressed in Fetal Brain (23.7), Testis (18.2), Heart (6.4), Ovary (6.3), and Bone marrow mesenchymal stem cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCAPER Gene



Protein tissue co-expression partners for SCAPER Gene

NURSA nuclear receptor signaling pathways regulating expression of SCAPER Gene:

SCAPER

SOURCE GeneReport for Unigene cluster for SCAPER Gene:

Hs.458986

mRNA Expression by UniProt/SwissProt for SCAPER Gene:

Q9BY12-SCAPE_HUMAN
Tissue specificity: Widely expressed with highest expression in testis.
genes like me logo Genes that share expression patterns with SCAPER: view

Primer Products

No data available for mRNA differential expression in normal tissues for SCAPER Gene

Orthologs for SCAPER Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAPER Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCAPER 34
  • 92.53 (n)
  • 92.84 (a)
SCAPER 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCAPER 34
  • 90.87 (n)
  • 90.85 (a)
SCAPER 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scaper 34
  • 87.94 (n)
  • 88.71 (a)
Scaper 16
Scaper 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCAPER 34
  • 99.74 (n)
  • 99.57 (a)
SCAPER 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCAPER 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves SCAPER 34
  • 75.6 (n)
  • 78.64 (a)
SCAPER 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAPER 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scaper 34
  • 69.55 (n)
  • 73.07 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16299 34
zebrafish
(Danio rerio)
Actinopterygii scaper 34
  • 67.66 (n)
  • 73.69 (a)
scaper 35
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ssp3 35
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y6B3B.4 35
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3404 35
  • 33 (a)
OneToOne
Species where no ortholog for SCAPER was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAPER Gene

ENSEMBL:
Gene Tree for SCAPER (if available)
TreeFam:
Gene Tree for SCAPER (if available)

Paralogs for SCAPER Gene

Pseudogenes.org Pseudogenes for SCAPER Gene

genes like me logo Genes that share paralogs with SCAPER: view

No data available for Paralogs for SCAPER Gene

Variants for SCAPER Gene

Sequence variations from dbSNP and Humsavar for SCAPER Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1607017 - 76,434,124(-) ACAAA(A/C)CCTCA reference, missense
rs3743176 -, - 76,404,573(+) TCCTG(C/T)GGCAT intron-variant, reference, missense
rs2585728 -- 76,703,887(-) GAAAT(C/T)TATCA intron-variant
rs2585730 -- 76,697,003(-) TTGAC(A/G)CATTT intron-variant
rs2585731 -- 76,695,774(-) TATTA(A/C)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAPER Gene

Variant ID Type Subtype PubMed ID
dgv109n111 CNV deletion 26073780
dgv1244n106 CNV deletion 24896259
dgv147e215 CNV deletion 23714750
dgv2627n100 CNV gain 25217958
dgv2628n100 CNV gain 25217958
dgv2629n100 CNV gain 25217958
dgv2630n100 CNV gain 25217958
dgv2631n100 CNV gain+loss 25217958
dgv2632n100 CNV gain 25217958
dgv2633n100 CNV loss 25217958
dgv2634n100 CNV loss 25217958
dgv439n67 CNV loss 20364138
dgv460e199 CNV deletion 23128226
dgv4632n54 CNV loss 21841781
dgv4633n54 CNV loss 21841781
dgv4634n54 CNV gain+loss 21841781
dgv4635n54 CNV loss 21841781
dgv4636n54 CNV gain 21841781
dgv4637n54 CNV gain+loss 21841781
dgv4638n54 CNV gain 21841781
dgv4639n54 CNV gain 21841781
dgv4640n54 CNV gain+loss 21841781
dgv4641n54 CNV loss 21841781
dgv4642n54 CNV gain 21841781
dgv4643n54 CNV loss 21841781
dgv4644n54 CNV loss 21841781
dgv4645n54 CNV gain 21841781
dgv4646n54 CNV gain 21841781
dgv4647n54 CNV gain+loss 21841781
dgv4648n54 CNV gain 21841781
dgv4649n54 CNV loss 21841781
dgv4650n54 CNV gain 21841781
dgv4651n54 CNV gain+loss 21841781
dgv4652n54 CNV loss 21841781
dgv64n73 CNV deletion 24416366
dgv747e212 CNV loss 25503493
dgv748e212 CNV gain 25503493
dgv749e212 CNV loss 25503493
dgv750e212 CNV gain 25503493
esv1002951 CNV deletion 20482838
esv2421572 CNV deletion 20811451
esv24977 CNV gain+loss 19812545
esv2659496 CNV deletion 23128226
esv2660976 CNV deletion 23128226
esv2662931 CNV deletion 23128226
esv2749895 CNV deletion 23290073
esv2749898 CNV deletion 23290073
esv2760041 CNV gain 17122850
esv2760392 CNV loss 21179565
esv2761977 CNV gain+loss 21179565
esv32734 CNV gain+loss 17666407
esv3306666 CNV mobile element insertion 20981092
esv3362311 CNV insertion 20981092
esv33866 CNV loss 17666407
esv3401742 CNV insertion 20981092
esv3424674 CNV insertion 20981092
esv3451825 CNV insertion 20981092
esv3569709 CNV gain 25503493
esv3584695 CNV loss 24956385
esv3636939 CNV loss 21293372
esv3636941 CNV loss 21293372
esv3636942 CNV loss 21293372
esv3636945 CNV loss 21293372
esv3636946 CNV gain 21293372
esv3636947 CNV loss 21293372
esv3636948 CNV loss 21293372
esv3636949 CNV loss 21293372
esv3636950 CNV gain 21293372
nsv1040852 CNV gain 25217958
nsv1042089 CNV loss 25217958
nsv1042514 CNV gain 25217958
nsv1043878 CNV gain+loss 25217958
nsv1049736 CNV loss 25217958
nsv1049886 CNV loss 25217958
nsv1050601 CNV gain 25217958
nsv1052133 CNV gain 25217958
nsv1070974 CNV deletion 25765185
nsv1116463 OTHER inversion 24896259
nsv116 CNV deletion 15895083
nsv1160305 CNV deletion 26073780
nsv1160306 CNV deletion 26073780
nsv1160310 CNV deletion 26073780
nsv1160311 CNV deletion 26073780
nsv1620 CNV deletion 18451855
nsv442706 CNV loss 18776908
nsv457206 CNV loss 19166990
nsv471254 CNV loss 18288195
nsv472172 CNV novel sequence insertion 20440878
nsv498853 CNV loss 21111241
nsv507790 OTHER sequence alteration 20534489
nsv507791 OTHER sequence alteration 20534489
nsv510667 CNV deletion 20534489
nsv510668 CNV deletion 20534489
nsv511549 CNV gain 21212237
nsv514786 CNV loss 21397061
nsv525769 CNV loss 19592680
nsv570038 CNV gain 21841781
nsv570039 CNV loss 21841781
nsv570063 CNV gain 21841781
nsv570077 CNV loss 21841781
nsv570079 CNV gain+loss 21841781
nsv570090 CNV loss 21841781
nsv570098 CNV gain 21841781
nsv570110 CNV loss 21841781
nsv820145 CNV gain 19587683
nsv820890 CNV deletion 20802225
nsv827392 CNV loss 20364138
nsv9278 CNV gain+loss 18304495
nsv974602 CNV duplication 23825009

Variation tolerance for SCAPER Gene

Residual Variation Intolerance Score: 7.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.61; 97.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCAPER Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCAPER

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAPER Gene

Disorders for SCAPER Gene

Relevant External Links for SCAPER

Genetic Association Database (GAD)
SCAPER
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCAPER

No disorders were found for SCAPER Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAPER Gene

Publications for SCAPER Gene

  1. SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. (PMID: 17698606) Tsang W.Y. … Dynlacht B.D. (J. Cell Biol. 2007) 2 3 4 65
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 65
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65

Products for SCAPER Gene

Sources for SCAPER Gene

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