Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SCAPER Gene

protein-coding   GIFtS: 49
GCID: GC15M076640

S-Phase Cyclin A-Associated Protein In The ER

(Previous name: zinc finger protein 291)
(Previous symbol: ZNF291)
  See SCAPER-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
S-Phase Cyclin A-Associated Protein In The ER1 2     KIAA14543 5
Zinc Finger Protein 2911 2 3     Zfp2912
ZNF2911 2 3     S Phase Cyclin A-Associated Protein In The Endoplasmic Reticulum2
S Phase Cyclin A-Associated Protein In The ER2 3     

External Ids:    HGNC: 130811   Entrez Gene: 498552   Ensembl: ENSG000001403867   OMIM: 6116115   UniProtKB: Q9BY123   

Export aliases for SCAPER gene to outside databases

Previous GC identifers: GC15M074428 GC15M053397


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SCAPER Gene:
SCAPER (S-phase cyclin A-associated protein in the ER) is a protein-coding gene. Diseases associated with SCAPER include composite lymphoma.

UniProtKB/Swiss-Prot: SCAPE_HUMAN, Q9BY12
Function: CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SCAPER gene promoter:
         MEF-2A   RORalpha1   aMEF-2   ZID   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCAPER promoter sequence
   Search Chromatin IP Primers for SCAPER

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCAPER


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q24.3   HGNC cytogenetic band: 15q24.3

SCAPER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCAPER gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M076640:  view genomic region     (about GC identifiers)

Start:
76,640,526 bp from pter      End:
77,197,785 bp from pter
Size:
557,260 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SCAPE_HUMAN, Q9BY12 (See protein sequence)
Recommended Name: S phase cyclin A-associated protein in the endoplasmic reticulum  
Size: 1400 amino acids; 158287 Da
Subunit: Interacts with CCNA2/CDK2 complex, but not with CCNA2/CDC2, CCNB1/CDC2 or CCNE1/CDK2 complexes, at
multiple phases of the cell cycle, including S and G2/M
Developmental stage: Expressed at each stage of the cell cycle, including G0, although the expression is somewhat
higher in late G1 and S phases
Sequence caution: Sequence=AAG47945.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH15212.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI07416.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAK29205.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: F5H7X8 H3BNR7 Q3B7X7 Q96BS9 Q9H3D8 Q9NT03 Q9P274
Alternative splicing: 3 isoforms:  Q9BY12-1   Q9BY12-2   Q9BY12-3   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCAPER: NX_Q9BY12

Explore proteomics data for SCAPER at MOPED

Post-translational modifications: 

  • Phosphorylated in vitro by the CCNA2/CDK2 complex1
  • Ubiquitination2 at Lys928, Lys1368
  • Modification sites at PhosphoSitePlus

  • See SCAPER Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139395.1  NP_065894.2  

    ENSEMBL proteins: 
     ENSP00000442190   ENSP00000454973   ENSP00000457234   ENSP00000455623   ENSP00000456508  
     ENSP00000455378   ENSP00000456987   ENSP00000457434   ENSP00000456065   ENSP00000455751  
     ENSP00000457382   ENSP00000455231   ENSP00000326924  

    SCAPER Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SCAPER
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SCAPER
    GenScript Custom Purified and Recombinant Proteins Services for SCAPER
    Novus Biologicals SCAPER Protein
    Novus Biologicals SCAPER Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCAPER

     
    Search eBioscience for Proteins for SCAPER 

    SCAPER Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SCAPER
    Novus Biologicals SCAPER Antibodies
    Abcam antibodies for SCAPER
    Cloud-Clone Corp. Antibodies for SCAPER
    Search ThermoFisher Antibodies for SCAPER
    LSBio Antibodies in human, mouse, rat for SCAPER

    SCAPER Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SCAPER
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCAPER
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCAPER
    Cloud-Clone Corp. CLIAs for SCAPER
    Search eBioscience for ELISAs for SCAPER 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    1 InterPro protein domain:
     IPR015880 Znf_C2H2-like

    Graphical View of Domain Structure for InterPro Entry Q9BY12

    ProtoNet protein and cluster: Q9BY12

    UniProtKB/Swiss-Prot: SCAPE_HUMAN, Q9BY12
    Similarity: Contains 1 C2H2-type zinc finger


    Find genes that share domains with SCAPER           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCAPE_HUMAN, Q9BY12
    Function: CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with SCAPER           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCAPER
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCAPER

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCAPER
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCAPER

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SCAPER using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SCAPER:
    hsa-miR-3121-3p hsa-miR-139-5p hsa-miR-556-3p hsa-miR-340 hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidSCAPER 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SCAPER
    Predesigned siRNA for gene silencing in human, mouse, rat SCAPER

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCAPER

    Clone
    Products:
         
    OriGene clones in human, mouse for SCAPER (see all 14)
    OriGene ORF clones in mouse, rat for SCAPER
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCAPER (NM_001145923)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCAPER
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAPER

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SCAPER
    Browse ESI BIO Cell Lines and PureStem Progenitors for SCAPER 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAPER


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SCAPE_HUMAN, Q9BY12: Endoplasmic reticulum. Nucleus. Note=Predominantly located in the endoplasmic reticulum,
    only a small portion is detected in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--

    Find genes that share ontologies with SCAPER           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCAPER
    Interactions:

        Search GeneGlobe Interaction Network for SCAPER

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for SCAPER (Q9BY123 ENSP000003269244) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    CELSR3Q9NYQ73, ENSP000001640244I2D: score=3 STRING: ENSP00000164024
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCAPER (SCAPE)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SCAPER gene (2 alternative transcripts): 
    NM_001145923.1  NM_020843.2  

    Unigene Cluster for SCAPER:

    S-phase cyclin A-associated protein in the ER
    Hs.458986  [show with all ESTs]
    Unigene Representative Sequence: NM_001145923
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000538941(uc002bbx.3) ENST00000563290(uc010bkr.3 uc002bby.3 uc002bca.1 uc002bcb.1)
    ENST00000562948 ENST00000563246 ENST00000303521(uc002bbz.1) ENST00000567601
    ENST00000569395 ENST00000568428 ENST00000564757 ENST00000563688 ENST00000569784
    ENST00000565507 ENST00000564590(uc002bcc.1) ENST00000565970 ENST00000564022
    ENST00000568549 ENST00000567618 ENST00000562890
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCAPER using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SCAPER:
    hsa-miR-3121-3p hsa-miR-139-5p hsa-miR-556-3p hsa-miR-340 hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidSCAPER 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SCAPER
    Predesigned siRNA for gene silencing in human, mouse, rat SCAPER
    Clone
    Products:
         
    OriGene clones in human, mouse for SCAPER (see all 14)
    OriGene ORF clones in mouse, rat for SCAPER
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SCAPER (NM_001145923)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCAPER
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAPER
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SCAPER
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCAPER
      QuantiTect SYBR Green Assays in human, mouse, rat SCAPER
      QuantiFast Probe-based Assays in human, mouse, rat SCAPER

    Additional mRNA sequence: 

    AF119814.1 AF242528.1 AK025663.1 AK056095.1 AK056515.1 AL137612.1 BC015212.1 BC070197.1 
    BC107415.1 BT006762.1 BX647285.1 

    24 DOTS entries:

    DT.310989  DT.100795262  DT.99948034  DT.100795259  DT.95374417  DT.92429300  DT.121028373  DT.121028400 
    DT.101966812  DT.121028389  DT.92415830  DT.100036009  DT.100730100  DT.121028388  DT.121028414  DT.121028449 
    DT.121028450  DT.121028460  DT.40114195  DT.92429301  DT.95374419  DT.100795265  DT.75174778  DT.97802990 

    Selected AceView cDNA sequences (see all 144):

    AA383215 AK056095 BX484434 AV706820 BG251026 BC015212 BP351689 BP368337 
    CR590728 BX100838 CD630440 AL137612 BT006762 NM_020843 CR625323 AK056515 
    BC070197 AI793036 BX951655 AA347106 AW474474 AI306396 BX280419 AA160056 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SCAPER expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAGGAAAT
    SCAPER Expression
    About this image


    SCAPER expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
     
     Limb (Muscoskeletal System)
    SCAPER Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCAPER Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458986

    UniProtKB/Swiss-Prot: SCAPE_HUMAN, Q9BY12
    Tissue specificity: Widely expressed with highest expression in testis

        Custom PCR Arrays for SCAPER
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SCAPER
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCAPER
    QuantiTect SYBR Green Assays in human, mouse, rat SCAPER
    QuantiFast Probe-based Assays in human, mouse, rat SCAPER
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAPER

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SCAPER gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scaper1 , 5 S phase cyclin A-associated protein in the ER1, 5 87.94(n)1
    88.71(a)1
      9 (30.13 cM)5
    2448911  NM_001081341.11  NP_001074810.11 
     555498835 
    chicken
    (Gallus gallus)
    Aves SCAPER1 S-phase cyclin A-associated protein in the ER 75.6(n)
    78.64(a)
      415352  XM_413736.4  XP_413736.4 
    lizard
    (Anolis carolinensis)
    Reptilia SCAPER6
    S-phase cyclin A-associated protein in the ER
    79(a)
    1 ↔ 1
    GL343374.1(970669-1076960)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162992 Xenopus laevis transcribed sequence with strong similarity more 76.83(n)    BJ047205.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scaper1 S phase cyclin A-associated protein in the ER 67.66(n)
    73.69(a)
      100144551  NM_001123047.1  NP_001116519.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ssp36
    short spindle 3
    20(a)
    1 ↔ 1
    2L(18916525-18943948)
    worm
    (Caenorhabditis elegans)
    Secernentea Y6B3B.46
    Protein Y6B3B.4 (Y6B3B.4) mRNA, complete cds
    18(a)
    1 ↔ 1
    I(13756737-13771773) WBGene00012389


    ENSEMBL Gene Tree for SCAPER (if available)
    TreeFam Gene Tree for SCAPER (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SCAPER gene

    Find genes that share paralogs with SCAPER           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SCAPER
    PGOHUM00000259004


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SCAPER (see all 9579)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725340601,2
    C--53737356(+) CATCA-/ATTGTTT 2 -- int10--------
    rs360725611,2
    C--56857077(+) TTTCC-/A/AG  
            
    AAAAA
    2 -- int10--------
    rs345034821,2
    C--57122179(+) AAAAAA/-TGTAC 2 -- int11Minor allele frequency- -:0.00NA 2
    rs802489071,2
    F--76640078(+) TGTTTG/CATCAG 2 -- int11Minor allele frequency- C:0.04WA 118
    rs24695531,2
    C,H--76640162(+) ATGAGA/GACAAG 2 -- int112Minor allele frequency- G:0.06NA WA CSA EA 374
    rs1424247101,2
    --76640395(+) ATTATC/TTGCTA 2 -- int10--------
    rs24601611,2
    C,F,A,H--76640430(+) TACAAC/TGCCCT 2 -- int119Minor allele frequency- T:0.13NS EA NA CSA WA 2344
    rs24692251,2
    C,F,A,H--76640658(-) TTCTTG/ATAATA 2 -- ut3110Minor allele frequency- A:0.09NS NA WA 1434
    rs1850210261,2
    --76640729(+) TTATCA/GTAAGA 2 -- ut310--------
    rs2003188101,2
    C--76640735(-) TTTCCA/GTCTTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SCAPER (76640526 - 76890526 bp, first 250kb of SCAPER)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SCAPER (see all 42):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv460e199CNV Deletion23128226
    esv1002951CNV Deletion20482838
    esv2749895CNV Deletion23290073
    esv2662931CNV Deletion23128226
    esv2749898CNV Deletion23290073
    esv2660976CNV Deletion23128226
    esv2659496CNV Deletion23128226
    nsv820890CNV Deletion20802225
    esv2421572CNV Deletion20811451
    esv270942CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCAPER
    DNA2.0 Custom Variant and Variant Library Synthesis for SCAPER

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611611    OMIM disorders: --

    1 disease for SCAPER:    
    About MalaCards
    composite lymphoma

    1 disease from the University of Copenhagen DISEASES database for SCAPER:
    Composite lymphoma

    Find genes that share disorders with SCAPER           About GenesLikeMe

    Genetic Association Database (GAD): SCAPER

    Export disorders for SCAPER gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SCAPER gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SCAPER)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. (PubMed id 17698606)1, 2, 3 Tsang W.Y.... Dynlacht B.D. (J. Cell Biol. 2007)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    3. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition. (PubMed id 19596686)1 Matafora V....Bachi A. (amp 2009)
    7. Double identity of SCAPER: a substrate and regulator of cyclin A/Cdk2. (PubMed id 18245951)1 Tsang W.Y. and Dynlacht B.D. (Cell Cycle 2008)
    8. Detection of an unstable non-coding tandem repeat in the ZNF291 gene. (PubMed id 17553665)1 Laura V....Annalisa B. (Mol. Cell. Probes 2007)
    9. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 49855 HGNC: 13081 AceView: ZNF291 Ensembl:ENSG00000140386 euGenes: HUgn49855
    ECgene: SCAPER H-InvDB: SCAPER

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1454

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SCAPER Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SCAPER gene:
    Search GeneIP for patents involving SCAPER

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SCAPER  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SCAPER  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SCAPER  
     OriGene qSTAR qPCR primer pairs in human, mouse for SCAPER   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SCAPER   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCAPER   OriGene Custom Protein Services for SCAPER  

     
     
     Block miRNA regulation of human, mouse, rat SCAPER using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SCAPER
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCAPER Predesigned siRNA for gene silencing in human, mouse, rat SCAPER
     QuantiFast Probe-based Assays in human, mouse, rat SCAPER QuantiTect SYBR Green Assays in human, mouse, rat SCAPER
     Custom PCR Arrays for SCAPER Search Chromatin IP Primers for SCAPER
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCAPER  Search GeneGlobe Interaction Network for SCAPER
     Regulatory tfbs in SCAPER promoter
     GenScript Custom Purified and Recombinant Proteins Services for SCAPER GenScript cDNA clones with any tag delivered in your preferred vector for SCAPER
     GenScript Custom Assay Services for SCAPER GenScript Custom overexpressing Cell Line Services for SCAPER
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SCAPER (SCAPE)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SCAPER antibodies
     SCAPER proteins
     SCAPER lysates
     Antibodies for SCAPER
     See all of Abcam's Antibodies, Kits and Proteins for SCAPER
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SCAPER
     Antibodies for SCAPER
     ELISAs for SCAPER
     CLIAs for SCAPER



     Browse ESI BIO Cell Lines and PureStem Progenitors for SCAPER
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAPER
     SwitchGear 3'UTR luciferase reporter plasmids for SCAPER
     SwitchGear Promoter luciferase reporter plasmids for SCAPER
     Search ThermoFisher Antibodies for SCAPER
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAPER
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCAPER
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCAPER
     LSBio Antibodies in human, mouse, rat for SCAPER
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SCAPER
      Search eBioscience for proteins for SCAPER
      Search eBioscience for elisas for SCAPER
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SCAPER gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4