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Aliases for SCAPER Gene

Aliases for SCAPER Gene

  • S-Phase Cyclin A Associated Protein In The ER 2 3 5
  • Zinc Finger Protein 291 2 3 4
  • ZNF291 3 4
  • S Phase Cyclin A-Associated Protein In The Endoplasmic Reticulum 3
  • S Phase Cyclin A-Associated Protein In The ER 4
  • KIAA1454 4
  • MSTP063 3
  • Zfp291 3

External Ids for SCAPER Gene

Previous HGNC Symbols for SCAPER Gene

  • ZNF291

Previous GeneCards Identifiers for SCAPER Gene

  • GC15M074428
  • GC15M076640
  • GC15M053397

Summaries for SCAPER Gene

GeneCards Summary for SCAPER Gene

SCAPER (S-Phase Cyclin A Associated Protein In The ER) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SCAPER Gene

  • CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.

Additional gene information for SCAPER Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAPER Gene

Genomics for SCAPER Gene

Regulatory Elements for SCAPER Gene

Enhancers for SCAPER Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H076345 1.5 Ensembl ENCODE dbSUPER 30.7 +558.9 558872 2.7 PKNOX1 ARID4B DMAP1 GLIS2 KLF7 SP3 TSHZ1 ZNF610 GLIS1 MYNN SCAPER ISL2 RCN2 ENSG00000270036 GC15M076371
GH15H076335 1.6 Ensembl ENCODE dbSUPER 26 +566.0 566026 8.8 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 MAN2C1 SCAPER DNM1P35 FBXO22 SIN3A ENSG00000260274 ETFA ISL2 NEIL1 LOC441728
GH15H076195 1.5 Ensembl ENCODE dbSUPER 20.4 +707.9 707858 4.3 PKNOX1 ARID4B DMAP1 SLC30A9 GLIS2 FOS DEK SP5 MXD4 PPARG SCAPER NRG4 TMEM266 ISL2 ETFA TSPAN3 LOC101929439 ENSG00000196274
GH15H076930 1.1 ENCODE 25.9 -26.0 -26040 3 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS SCAPER RCN2 ENSG00000269951 ENSG00000261244 PIR38724 GC15P076918
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCAPER on UCSC Golden Path with GeneCards custom track

Promoters for SCAPER Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for SCAPER Gene

Genomic Locations for SCAPER Gene
557,552 bases
Minus strand

Genomic View for SCAPER Gene

Genes around SCAPER on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAPER Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAPER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAPER Gene

Proteins for SCAPER Gene

  • Protein details for SCAPER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    S phase cyclin A-associated protein in the endoplasmic reticulum
    Protein Accession:
    Secondary Accessions:
    • F5H7X8
    • H3BNR7
    • Q3B7X7
    • Q96BS9
    • Q9H3D8
    • Q9NT03
    • Q9P274

    Protein attributes for SCAPER Gene

    1400 amino acids
    Molecular mass:
    158287 Da
    Quaternary structure:
    • Interacts with CCNA2/CDK2 complex, but not with CCNA2/CDC2, CCNB1/CDC2 or CCNE1/CDK2 complexes, at multiple phases of the cell cycle, including S and G2/M.
    • Sequence=AAG47945.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15212.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI07416.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAK29205.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SCAPER Gene


neXtProt entry for SCAPER Gene

Post-translational modifications for SCAPER Gene

  • Phosphorylated in vitro by the CCNA2/CDK2 complex.
  • Ubiquitination at isoforms=2, 3928 and Lys1368
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCAPER Gene

Domains & Families for SCAPER Gene

Gene Families for SCAPER Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SCAPER Gene

Suggested Antigen Peptide Sequences for SCAPER Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SCAPER: view

No data available for UniProtKB/Swiss-Prot for SCAPER Gene

Function for SCAPER Gene

Molecular function for SCAPER Gene

UniProtKB/Swiss-Prot Function:
CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.

Phenotypes From GWAS Catalog for SCAPER Gene

Gene Ontology (GO) - Molecular Function for SCAPER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SCAPER: view

Phenotypes for SCAPER Gene

genes like me logo Genes that share phenotypes with SCAPER: view

Animal Model Products

CRISPR Products

miRNA for SCAPER Gene

miRTarBase miRNAs that target SCAPER

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAPER Gene

Localization for SCAPER Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAPER Gene

Endoplasmic reticulum. Nucleus. Note=Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAPER gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCAPER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SCAPER: view

Pathways & Interactions for SCAPER Gene

SuperPathways for SCAPER Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAPER Gene


No data available for Pathways by source and SIGNOR curated interactions for SCAPER Gene

Drugs & Compounds for SCAPER Gene

No Compound Related Data Available

Transcripts for SCAPER Gene

Unigene Clusters for SCAPER Gene

S-phase cyclin A-associated protein in the ER:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAPER Gene

No ASD Table

Relevant External Links for SCAPER Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAPER Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCAPER Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCAPER Gene

This gene is overexpressed in Fetal Brain (23.7), Testis (18.2), Heart (6.4), Ovary (6.3), and Bone marrow mesenchymal stem cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCAPER Gene

Protein tissue co-expression partners for SCAPER Gene

NURSA nuclear receptor signaling pathways regulating expression of SCAPER Gene:


SOURCE GeneReport for Unigene cluster for SCAPER Gene:


mRNA Expression by UniProt/SwissProt for SCAPER Gene:

Tissue specificity: Widely expressed with highest expression in testis.

Evidence on tissue expression from TISSUES for SCAPER Gene

  • Nervous system(4.6)
  • Heart(4.3)
  • Intestine(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with SCAPER: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAPER Gene

Orthologs for SCAPER Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAPER Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCAPER 33 34
  • 99.74 (n)
(Bos Taurus)
Mammalia SCAPER 33 34
  • 92.53 (n)
(Canis familiaris)
Mammalia SCAPER 33 34
  • 90.87 (n)
(Mus musculus)
Mammalia Scaper 33 16 34
  • 87.94 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
-- 34
  • 81 (a)
(Monodelphis domestica)
Mammalia SCAPER 34
  • 80 (a)
(Gallus gallus)
Aves SCAPER 33 34
  • 75.6 (n)
(Anolis carolinensis)
Reptilia SCAPER 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scaper 33
  • 69.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16299 33
(Danio rerio)
Actinopterygii scaper 33 34
  • 67.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta ssp3 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea Y6B3B.4 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3404 34
  • 33 (a)
Species where no ortholog for SCAPER was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAPER Gene

Gene Tree for SCAPER (if available)
Gene Tree for SCAPER (if available)

Paralogs for SCAPER Gene Pseudogenes for SCAPER Gene

genes like me logo Genes that share paralogs with SCAPER: view

No data available for Paralogs for SCAPER Gene

Variants for SCAPER Gene

Sequence variations from dbSNP and Humsavar for SCAPER Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000001391 -- 76,764,028(+) CATGT(C/T)CTTTG intron-variant
rs1000003372 -- 76,511,819(+) ACAAA(A/G)ATACA intron-variant
rs1000006348 -- 76,502,576(+) GTGGG(C/G)TGGGA intron-variant
rs1000010786 -- 76,706,617(+) CTAGA(C/G)GGTCT intron-variant
rs1000015963 -- 76,688,156(+) TCTCA(C/T)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAPER Gene

Variant ID Type Subtype PubMed ID
nsv974602 CNV duplication 23825009
nsv9278 CNV gain+loss 18304495
nsv827392 CNV loss 20364138
nsv820890 CNV deletion 20802225
nsv820145 CNV gain 19587683
nsv570110 CNV loss 21841781
nsv570098 CNV gain 21841781
nsv570090 CNV loss 21841781
nsv570079 CNV gain+loss 21841781
nsv570077 CNV loss 21841781
nsv570063 CNV gain 21841781
nsv570039 CNV loss 21841781
nsv570038 CNV gain 21841781
nsv525769 CNV loss 19592680
nsv514786 CNV loss 21397061
nsv511549 CNV gain 21212237
nsv510668 CNV deletion 20534489
nsv510667 CNV deletion 20534489
nsv507791 OTHER sequence alteration 20534489
nsv507790 OTHER sequence alteration 20534489
nsv498853 CNV loss 21111241
nsv472172 CNV novel sequence insertion 20440878
nsv471254 CNV loss 18288195
nsv457206 CNV loss 19166990
nsv442706 CNV loss 18776908
nsv1620 CNV deletion 18451855
nsv1160311 CNV deletion 26073780
nsv1160310 CNV deletion 26073780
nsv1160306 CNV deletion 26073780
nsv1160305 CNV deletion 26073780
nsv116 CNV deletion 15895083
nsv1116463 OTHER inversion 24896259
nsv1070974 CNV deletion 25765185
nsv1052133 CNV gain 25217958
nsv1050601 CNV gain 25217958
nsv1049886 CNV loss 25217958
nsv1049736 CNV loss 25217958
nsv1043878 CNV gain+loss 25217958
nsv1042514 CNV gain 25217958
nsv1042089 CNV loss 25217958
nsv1040852 CNV gain 25217958
esv3636950 CNV gain 21293372
esv3636949 CNV loss 21293372
esv3636948 CNV loss 21293372
esv3636947 CNV loss 21293372
esv3636946 CNV gain 21293372
esv3636945 CNV loss 21293372
esv3636942 CNV loss 21293372
esv3636941 CNV loss 21293372
esv3636939 CNV loss 21293372
esv3584695 CNV loss 24956385
esv3569709 CNV gain 25503493
esv3451825 CNV insertion 20981092
esv3424674 CNV insertion 20981092
esv3401742 CNV insertion 20981092
esv33866 CNV loss 17666407
esv3362311 CNV insertion 20981092
esv3306666 CNV mobile element insertion 20981092
esv32734 CNV gain+loss 17666407
esv2761977 CNV gain+loss 21179565
esv2760392 CNV loss 21179565
esv2760041 CNV gain 17122850
esv2749898 CNV deletion 23290073
esv2749895 CNV deletion 23290073
esv2662931 CNV deletion 23128226
esv2660976 CNV deletion 23128226
esv2659496 CNV deletion 23128226
esv24977 CNV gain+loss 19812545
esv2421572 CNV deletion 20811451
esv1002951 CNV deletion 20482838
dgv750e212 CNV gain 25503493
dgv749e212 CNV loss 25503493
dgv748e212 CNV gain 25503493
dgv747e212 CNV loss 25503493
dgv64n73 CNV deletion 24416366
dgv4652n54 CNV loss 21841781
dgv4651n54 CNV gain+loss 21841781
dgv4650n54 CNV gain 21841781
dgv4649n54 CNV loss 21841781
dgv4648n54 CNV gain 21841781
dgv4647n54 CNV gain+loss 21841781
dgv4646n54 CNV gain 21841781
dgv4645n54 CNV gain 21841781
dgv4644n54 CNV loss 21841781
dgv4643n54 CNV loss 21841781
dgv4642n54 CNV gain 21841781
dgv4641n54 CNV loss 21841781
dgv4640n54 CNV gain+loss 21841781
dgv4639n54 CNV gain 21841781
dgv4638n54 CNV gain 21841781
dgv4637n54 CNV gain+loss 21841781
dgv4636n54 CNV gain 21841781
dgv4635n54 CNV loss 21841781
dgv4634n54 CNV gain+loss 21841781
dgv4633n54 CNV loss 21841781
dgv4632n54 CNV loss 21841781
dgv460e199 CNV deletion 23128226
dgv439n67 CNV loss 20364138
dgv2634n100 CNV loss 25217958
dgv2633n100 CNV loss 25217958
dgv2632n100 CNV gain 25217958
dgv2631n100 CNV gain+loss 25217958
dgv2630n100 CNV gain 25217958
dgv2629n100 CNV gain 25217958
dgv2628n100 CNV gain 25217958
dgv2627n100 CNV gain 25217958
dgv147e215 CNV deletion 23714750
dgv1244n106 CNV deletion 24896259
dgv109n111 CNV deletion 26073780

Variation tolerance for SCAPER Gene

Residual Variation Intolerance Score: 7.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.61; 97.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCAPER Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAPER Gene

Disorders for SCAPER Gene

Relevant External Links for SCAPER

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCAPER Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAPER Gene

Publications for SCAPER Gene

  1. SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. (PMID: 17698606) Tsang WY … Dynlacht BD (The Journal of cell biology 2007) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. F-box only protein 9 is an E3 ubiquitin ligase of PPARγ. (PMID: 27197753) Lee KW … Park KS (Experimental & molecular medicine 2016) 3 60
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60

Products for SCAPER Gene

Sources for SCAPER Gene

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