SCAP Gene
protein-coding GIFtS: 59
GCID: GC03M047430
|
|
SREBF chaperone
| |
Aliases
for SCAP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SREBF Chaperone1 2 | | KIAA01991 3 | | SREBP Cleavage-Activating Protein2 3 | | Sterol Regulatory Element Binding Protein Cleavage-Activating Protein2 | | Sterol Regulatory Element-Binding Protein Cleavage-Activating Protein2 |
Export aliases for SCAP gene to outside databasesPrevious GC identifers: GC03M047243 GC03M046675 GC03M047415 |
Summaries
for SCAP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SCAP:
This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol,this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER tothe Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: SCAP_HUMAN, Q12770Function: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBFcomplex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrationsleads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrationstrigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal,recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi,release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulationof LDLR, INSIG1 and the mevalonate pathway (By similarity)
Gene Wiki entry for SCAP (SREBP cleavage activating protein)
|
Genomic Views
for SCAP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCAP gene promoter:
Max1 GR Pax-5 FOXO3 FOXO3b Egr-4 RORalpha1 c-Rel FOXO3a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCAP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31SCAP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M047430: view genomic region
(about GC identifiers)
Start:
|
47,455,184 bp from pter |
End:
|
47,518,616 bp from pter |
Size:
|
63,433 bases |
Orientation:
|
minus strand |
|
Proteins
for SCAP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCAP_HUMAN, Q12770 (See
protein sequence)Recommended Name: Sterol regulatory element-binding protein cleavage-activating protein Size: 1279 amino acids; 139729 Da
Subunit: Membrane region forms a homotetramer. Forms a stable complex with SREBF1/SREBP1 or SREBF2/SREBP2 through itsC-terminal cytoplasmic domain. Forms a ternary complex with INSIG1 or INSIG2 through its transmembrane domains at highsterol concentrations. Interacts with the SEC23/SEC24 complex in a SAR1-GTP-dependent manner through an ER exportsignal in its third cytoplasmic loop. Binds cholesterol through its SSC domain (By similarity). Component ofSCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B,thereby reducing SREBF2 proteolytic processing. Interacts with RNF139; the interaction inhibits the interaction ofSCAP with SEC24B and hampering the ER to Golgi transport of the SCAP/SREBP complex
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Golgi apparatusmembrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-passmembrane protein (By similarity). Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols (Bysimilarity)
Sequence caution: Sequence=BAA12111.2; Type=Erroneous initiation; Sequence=BAC11673.1; Type=Erroneous initiation;
Secondary accessions: Q8N2E0 Q8WUA1Alternative splicing: 4 isoforms: Q12770-1 Q12770-2 Q12770-3 Q12770-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SCAP: NX_Q12770
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12770
SCAP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036367.2
ENSEMBL proteins: ENSP00000324296 ENSP00000265565 ENSP00000409183 ENSP00000401819 ENSP00000408102 ENSP00000423419 ENSP00000389796 ENSP00000415195 ENSP00000416847 ENSP00000438956 Reactome Protein details: Q12770
Human Recombinant Protein Products for SCAP:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
SCAP for ontologies About GeneDecksing
SCAP Antibody Products:
Assay Products for SCAP: |
Protein
Domains /
Families
for SCAP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCAP for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q12770ProtoNet protein and cluster: Q12770 UniProtKB/Swiss-Prot: SCAP_HUMAN, Q12770Domain: Cholesterol bound to SSC domain of SCAP or oxysterol bound to INSIG1/2 leads to masking of an ER export signalon SCAP possibly by moving the signal further away from the ER membrane (By similarity)Similarity: Belongs to the WD repeat SCAP familySimilarity: Contains 1 SSD (sterol-sensing) domainSimilarity: Contains 7 WD repeats |
Function
for SCAP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SCAP_HUMAN, Q12770Function: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBFcomplex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrationsleads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrationstrigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal,recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi,release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulationof LDLR, INSIG1 and the mevalonate pathway (By similarity)Induction: By androgen-bound AR and glucocorticoid-bound NR3C1 in a prostate cancer cell line (LNCaP) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SCAP for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Scap):
SCAP for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCAP (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SCAP (NM_012235) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCAP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAP |
|
Pathways & Interactions
for SCAP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of Cholesterol Biosynthesis by SREBP (SREBF) | | | 2 | Metabolism | | | 3 | Transcription_Androgen Receptor nuclear signaling | | | 4 | SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG | | | 5 | COPII (Coat Protein 2) Mediated Vesicle Transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SCAP
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SCAP
1  GeneGo (Thomson Reuters) Pathway for SCAP
1  BioSystems Pathway for SCAP
5/7 
Reactome Pathways for SCAP (see all 7)
SCAP for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCAP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/14 Interacting proteins for SCAP (Q127703 ENSP000002655654) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
SCAP for ontologies About GeneDecksing
|
Drugs & Compounds
for SCAP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SCAP for compounds About GeneDecksing
 Browse Tocris compounds for SCAP
1 HMDB Compound for SCAP About this table
10/11 Novoseek chemical compound relationships for SCAP gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sterol |
91.7 |
86 |
10500160 (6), 9642295 (3), 15133039 (2), 12242332 (2) (see all 45) |
| cholesterol |
73.2 |
45 |
12191470 (4), 15260976 (4), 15728349 (3), 12202038 (3) (see all 22) |
| 25-hydroxycholesterol |
67 |
2 |
15388640 (1), 12191470 (1) |
| lipid |
49.1 |
13 |
10570913 (2), 17666524 (1), 10570919 (1), 15085196 (1) (see all 10) |
| lovastatin |
48.5 |
2 |
12524230 (2) |
| squalene |
39.2 |
2 |
14596646 (1) |
| fatty acid |
35.9 |
2 |
9242699 (1) |
| pravastatin |
28.5 |
1 |
11683781 (1) |
| simvastatin |
21 |
2 |
16158080 (2) |
| alanine |
0 |
1 |
15728349 (1) |
Search CenterWatch for drugs/clinical trials and news about SCAP
|
Transcripts
for SCAP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCAP gene: NM_012235.2 Unigene Cluster for SCAP: SREBF chaperone Hs.531789 [show with all ESTs]Unigene Representative Sequence: NM_01223515 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000320017 ENST00000265565(uc003crh.1 uc011baz.1 uc003crg.2)
ENST00000416208 ENST00000465628 ENST00000468965 ENST00000494938 ENST00000428413
ENST00000487942 ENST00000416847 ENST00000495603 ENST00000420588 ENST00000485967
ENST00000448217 ENST00000441517 ENST00000545718
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCAP (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SCAP (NM_012235) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCAP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAP |
Additional cDNA sequence: AK027402.1 AK074312.1 AK075528.1 AK291484.1 AK300311.1 BC020987.1 BC027207.2 D83782.2 23 DOTS entries: DT.447628 DT.100766081 DT.92445981 DT.100836596 DT.100698719 DT.100812388 DT.75122952 DT.120855174 DT.120855180 DT.120855234 DT.75139635 DT.92445979 DT.95113791 DT.95204122 DT.100028783 DT.92024713 DT.95204128 DT.100028784 DT.100728775 DT.120855224 DT.120855241 DT.91697305 DT.95239559 24/293 AceView cDNA sequences (see all 293): AU124203 AI560986 BQ900914 AK091005 AA301053 BM149404 BG697947 BU501866 CR625407 BQ005119 BQ220011 D83782 BU633186 BM752168 CB850691 BQ068072 BM787881 BG577101 AA968905 BU172323 BM726771 BM700642 BU848632 BX401167
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SCAP (see all 12) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SCAP
|
Expression
for SCAP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCAP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTGCTCA
About this image
See SCAP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCAP
SOURCE GeneReport for Unigene cluster: Hs.531789
SABiosciences Expression via Pathway-Focused PCR Arrays including SCAP:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCAP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCAP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCAP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCAP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAP |
Orthologs
for SCAP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SCAP gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for SCAP (if available)
TreeFam Gene Tree for SCAP (if available) |
Paralogs
for SCAP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SCAP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCAP (47455184 - 47518616 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for SCAP
9 CNVs: 91300 36151 43505 36150 79759 63462 22510 62055 23686
1 Indel: 79760
Human Gene Mutation Database (HGMD): SCAP
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCAP |
|
Disorders
/ Diseases
for SCAP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCAP for disorders About GeneDecksing
OMIM gene information: 601510
OMIM disorders: --
14  diseases for SCAP: About MalaCardssmith-lemli-opitz syndrome syringocystadenoma papilliferum cholesterol apocrine adenoma
coronary heart disease hypercholesterolemia myocardial infarction nevus
prostate cancer atherosclerosis adenoma prostatitis
hypoxia hepatitis
1 disease from the University of Copenhagen DISEASES database for SCAP:Smith-Lemli-Opitz syndrome 6 Novoseek disease relationships for SCAP gene About this table
Human Genome Epidemiology (HuGE) Navigator: SCAP (16 documents)
Export disorders for SCAP gene to outside databases
|
Publications
for SCAP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCAP gene, integrated from 9 sources (see all 117):
(articles sorted by number of sources associating them with SCAP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic structure and chromosomal mapping of the human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) gene. (PubMed id 10570913)1, 2, 3, 9 Nakajima T.... Emi M. (1999)
- Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2, 3 Nagase T.... Nomura N. (1996)
- A common Ile796Val polymorphism of the human SREBP cleavage- activating protein (SCAP) gene. (PubMed id 10570919)1, 2, 9 Iwaki K.... Emi M. (1999)
- The sterol-sensing endoplasmic reticulum (ER) membran e protein TRC8 hampers ER to Golgi transport of sterol regulatory element-bindi ng protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cle avage. (PubMed id 19706601)1, 2, 9 Irisawa M....Sato R. (2009)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. (PubMed id 8898195)1, 3 Hua X....Brown M.S. (1996)
- Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein. (PubMed id 9242699)1, 9 Sakai J....Goldstein J.L. (1997)
|
External Searches for SCAP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCAP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing SCAP gene
(According to HUGE)
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Specialized Databases showing SCAP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SCAP | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for SCAP gene:
Search GeneIP for patents involving SCAP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SCAP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SCAP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCAP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCAP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SCAP | | OriGene 3'-UTR Clone for SCAP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCAP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SCAP | | OriGene Custom Protein Services for SCAP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCAP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCAP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCAP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCAP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCAP |
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| | | | Search Tocris compounds for SCAP |
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 | | | SCAP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAP |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SCAP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAP |
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