SCAND3 Gene
protein-coding GIFtS: 41
GCID: GC06M028539
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|
SCAN domain containing 3(Previous names: zinc finger protein 305 pseudogene 2, zinc finger protein...)
(Previous symbols: ZNF305P2, ZNF452)
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Aliases
for SCAND3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SCAN Domain Containing 31 2 | | KIAA19251 3 | | ZNF305P21 2 3 | | FLJ310871 | | ZNF4521 2 3 | | DJ1186N24.31 | | ZFP38-L1 2 | | DJ1186N24.3 (Novel Zinc Finger Protein)2 | | Zinc Finger Protein 305 Pseudogene 21 2 | | SCAN Domain-Containing Protein 32 | | Zinc Finger Protein 4521 2 | | Protein ZNF4523 |
Export aliases for SCAND3 gene to outside databasesPrevious GC identifers: GC06M028648 GC06M028347 |
Summaries
for SCAND3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for SCAND3 (ZNF452)
|
Genomic Views
for SCAND3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCAND3 gene promoter:
RFX1 NRSF form 1 Olf-1 NRSF form 2 TGIF MRF-2 Roaz
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCAND3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAND3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p21.33SCAND3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M028539: view genomic region
(about GC identifiers)
Start:
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28,539,407 bp from pter |
End:
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28,583,989 bp from pter |
Size:
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44,583 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr6-,ALT_REF_LOCI_2 28,541,284-28,594,300 |
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Proteins
for SCAND3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCND3_HUMAN, Q6R2W3 (See
protein sequence)Recommended Name: SCAN domain-containing protein 3 Size: 1325 amino acids; 151666 Da
Secondary accessions: Q2NKL9 Q5SRJ3 Q8TCN2 Q96MV9 Q96PW3Explore the universe of human proteins at neXtProt for SCAND3: NX_Q6R2W3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6R2W3
SCAND3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443155.1
ENSEMBL proteins: ENSP00000395259
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SCAND3 for ontologies About GeneDecksing
SCAND3 Antibody Products:
Assay Products for SCAND3: |
Protein
Domains /
Families
for SCAND3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCAND3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q6R2W3ProtoNet protein and cluster: Q6R2W3 2 Blocks protein families: IPB003309 Transcriptional regulator SCAN IPB008906 HAT dimerisation
UniProtKB/Swiss-Prot: SCND3_HUMAN, Q6R2W3Similarity: Contains 1 integrase catalytic domainSimilarity: Contains 1 SCAN box domain |
Function
for SCAND3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCAND3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAND3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SCAND3 (NM_052923) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCAND3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAND3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAND3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0046983 | protein dimerization activity |
IEA | -- |
SCAND3 for ontologies About GeneDecksing
|
Pathways & Interactions
for SCAND3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCAND3
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015074 | DNA integration |
IEA | -- | | GO:0016032 | viral reproduction |
IEA | -- |
SCAND3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SCAND3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SCAND3
Search CenterWatch for drugs/clinical trials and news about SCAND3 / SCND3
|
Transcripts
for SCAND3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCAND3 gene: NM_052923.1 Unigene Cluster for SCAND3: SCAN domain containing 3 Hs.176980 [show with all ESTs]Unigene Representative Sequence: AY5176314 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000452236(uc003nlo.3) ENST00000530247 ENST00000526291 ENST00000524745
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCAND3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAND3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SCAND3 (NM_052923) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCAND3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAND3 |
Additional cDNA sequence: AB067512.1 AK056369.1 AL832486.1 AY517631.1 BC110834.1 BC111741.1 BC111742.1 BX647791.1 2 DOTS entries: DT.101963668 DT.121384762 22 AceView cDNA sequences: AA480069 AY517631 NM_052923 AI820939 CA396529 AB067512 AL703533 BX642445 AL713690 BU506797 CD656189 AL708822 AL832486 BU567407 AA481935 BX647791 AL712109 AA642183 AK056369 AI338991 AI827682 AW341389
GeneLoc Exon Structure
|
Expression
for SCAND3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCAND3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCATAATT
About this image
See SCAND3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCAND3
SOURCE GeneReport for Unigene cluster: Hs.176980
SABiosciences Custom PCR Arrays for SCAND3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCAND3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCAND3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCAND3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCAND3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAND3 |
Orthologs
for SCAND3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SCAND3 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1005357301 |
SCAN domain-containing protein 3-like |
50.2(n)
41.34(a) |
|
100535730 XM_003199370.1 XP_003199418.1 |
Species with no ortholog for SCAND3
ENSEMBL Gene Tree for SCAND3 (if available)
TreeFam Gene Tree for SCAND3 (if available) |
Paralogs
for SCAND3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCAND3 gene
- ZBED52 KRBA22 C5orf542 GTF2IRD22 FAM200A2 GTF2IRD2B2 FAM200B2 EPM2AIP12
18 SIMAP similar genes for SCAND3 using alignment to 2 protein entries: SCND3_HUMAN (see all proteins):LOC100128510 SCAND1 KRBA2 ZSCAN16 ZSCAN23 ZNF396
ZNF24 ZNF174 ZNF434 DKFZp434K202 ZNF483 FAM200A
ZBED5 ZSCAN18 ZNF18 ZNF397 C5orf54 MZF1
SCAND3 for paralogs About GeneDecksing
|
Genomic Variants
for SCAND3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCAND3 (28539407 - 28583989 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SCAND3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCAND3 |
|
Disorders
/ Diseases
for SCAND3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCAND3 for disorders About GeneDecksing
2  diseases for SCAND3: About MalaCardssickle cell anemia anemia
Export disorders for SCAND3 gene to outside databases
|
Publications
for SCAND3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCAND3 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SCAND3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T....Ohara O. (2001)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
|
External Searches for SCAND3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCAND3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCAND3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SCAND3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SCAND3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SCAND3 gene:
Search GeneIP for patents involving SCAND3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCAND3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SCAND3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCAND3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCAND3 | | | OriGene Protein Over-expression Lysate for SCAND3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SCAND3 | | OriGene 3'-UTR Clone for SCAND3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAND3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCAND3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SCAND3 | | OriGene Custom Protein Services for SCAND3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCAND3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCAND3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAND3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCAND3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCAND3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCAND3 |
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 |  |  |  | |
| | | | Search Tocris compounds for SCAND3 |
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 | | | SCAND3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAND3 |
|  |  |  | | | | Search ThermoFisher Antibodies for SCAND3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAND3 |
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