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Aliases for SCAND1 Gene

Aliases for SCAND1 Gene

  • SCAN Domain Containing 1 2 3
  • SDP1 3 4 6
  • SCAN Domain-Containing 1 2 3
  • RAZ1 3 6
  • SCAN Domain-Containing Protein 1 3
  • SCAN-Related Protein RAZ1 3

External Ids for SCAND1 Gene

Previous GeneCards Identifiers for SCAND1 Gene

  • GC20M034231
  • GC20M035209
  • GC20M035256
  • GC20M034004
  • GC20M034542
  • GC20M031319

Summaries for SCAND1 Gene

Entrez Gene Summary for SCAND1 Gene

  • This gene encodes a SCAN box domain-containing protein. The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. This protein binds to and may regulate the function of the transcription factor myeloid zinc finger 1B. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]

GeneCards Summary for SCAND1 Gene

SCAND1 (SCAN Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is ZNF449.

UniProtKB/Swiss-Prot for SCAND1 Gene

  • May regulate transcriptional activity

Gene Wiki entry for SCAND1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAND1 Gene

Genomics for SCAND1 Gene

Regulatory Elements for SCAND1 Gene

Genomic Location for SCAND1 Gene

Start:
35,953,617 bp from pter
End:
35,959,472 bp from pter
Size:
5,856 bases
Orientation:
Minus strand

Genomic View for SCAND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCAND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAND1 Gene

Proteins for SCAND1 Gene

  • Protein details for SCAND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57086-SCND1_HUMAN
    Recommended name:
    SCAN domain-containing protein 1
    Protein Accession:
    P57086
    Secondary Accessions:
    • Q6IAG7

    Protein attributes for SCAND1 Gene

    Size:
    179 amino acids
    Molecular mass:
    19082 Da
    Quaternary structure:
    • Interacts with ZNF202

neXtProt entry for SCAND1 Gene

Proteomics data for SCAND1 Gene at MOPED

Post-translational modifications for SCAND1 Gene

  • Ubiquitination at Lys144
  • Modification sites at PhosphoSitePlus

Other Protein References for SCAND1 Gene

Antibody Products

No data available for DME Specific Peptides for SCAND1 Gene

Domains for SCAND1 Gene

Protein Domains for SCAND1 Gene

Suggested Antigen Peptide Sequences for SCAND1 Gene

Graphical View of Domain Structure for InterPro Entry

P57086

UniProtKB/Swiss-Prot:

SCND1_HUMAN :
  • P57086
Domain:
  • Contains 1 SCAN box domain.
genes like me logo Genes that share domains with SCAND1: view

No data available for Gene Families for SCAND1 Gene

Function for SCAND1 Gene

Molecular function for SCAND1 Gene

UniProtKB/Swiss-Prot Function: May regulate transcriptional activity

Gene Ontology (GO) - Molecular Function for SCAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity ISS --
GO:0003713 transcription coactivator activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with SCAND1: view

Phenotypes for SCAND1 Gene

genes like me logo Genes that share phenotypes with SCAND1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SCAND1 Gene

Localization for SCAND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAND1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCAND1 Gene COMPARTMENTS Subcellular localization image for SCAND1 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SCAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with SCAND1: view

Pathways for SCAND1 Gene

SuperPathways for SCAND1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with SCAND1: view

No data available for Pathways by source for SCAND1 Gene

Transcripts for SCAND1 Gene

Unigene Clusters for SCAND1 Gene

SCAN domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCAND1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAND1 Gene

No ASD Table

Relevant External Links for SCAND1 Gene

GeneLoc Exon Structure for
SCAND1
ECgene alternative splicing isoforms for
SCAND1

Expression for SCAND1 Gene

mRNA expression in normal human tissues for SCAND1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAND1 Gene

SOURCE GeneReport for Unigene cluster for SCAND1 Gene Hs.584909

genes like me logo Genes that share expressions with SCAND1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCAND1 Gene

Orthologs for SCAND1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCAND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAND1 35
  • 99.63 (n)
  • 98.88 (a)
SCAND1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCAND1 35
  • 77.34 (n)
  • 74.72 (a)
SCAND1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCAND1 35
  • 81.27 (n)
  • 78.65 (a)
SCAND1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scand1 35
  • 80.41 (n)
  • 79.39 (a)
Scand1 16
Scand1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCAND1 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Scand1 35
  • 79.58 (n)
  • 77.46 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 6 (a)
ManyToMany
-- 36
  • 6 (a)
ManyToMany
-- 36
  • 6 (a)
ManyToMany
-- 36
  • 9 (a)
ManyToMany
-- 36
  • 8 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
Species with no ortholog for SCAND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCAND1 Gene

ENSEMBL:
Gene Tree for SCAND1 (if available)
TreeFam:
Gene Tree for SCAND1 (if available)

Paralogs for SCAND1 Gene

Paralogs for SCAND1 Gene

genes like me logo Genes that share paralogs with SCAND1: view

Variants for SCAND1 Gene

Sequence variations from dbSNP and Humsavar for SCAND1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1043006 -- 35,953,776(-) GATCC(C/G)CCGCC missense, reference
rs1043010 -- 35,953,773(-) CCGCC(C/G)CCGCA missense, reference
rs3171387 -- 35,953,659(-) ACCCC(A/C)CCCCG utr-variant-3-prime
rs3180131 -- 35,954,465(-) CCGCA(C/G)GCGCT utr-variant-5-prime, missense, reference
rs3180680 -- 35,953,625(-) CAGCG(A/C)CTGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SCAND1 Gene

Variant ID Type Subtype PubMed ID
nsv526188 CNV Gain 19592680
nsv522947 CNV Gain 19592680
nsv912863 CNV Loss 21882294
nsv912864 CNV Loss 21882294
nsv833964 CNV Loss 17160897

Relevant External Links for SCAND1 Gene

HapMap Linkage Disequilibrium report
SCAND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAND1 Gene

Disorders for SCAND1 Gene

Relevant External Links for SCAND1

Genetic Association Database (GAD)
SCAND1
Human Genome Epidemiology (HuGE) Navigator
SCAND1
genes like me logo Genes that share disorders with SCAND1: view

No data available for UniProtKB/Swiss-Prot for SCAND1 Gene

Publications for SCAND1 Gene

  1. Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations. (PMID: 10777584) Sander T.L. … Morris J.F. (J. Biol. Chem. 2000) 2 3 23
  2. The SCAN domain mediates selective oligomerization. (PMID: 10747874) Schumacher C. … Wagner S. (J. Biol. Chem. 2000) 2 3 4
  3. Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization. (PMID: 12383503) Sander T.L. … Morris J.F. (Gene 2002) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 48

Products for SCAND1 Gene

Sources for SCAND1 Gene

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