Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SCAND1 Gene

Aliases for SCAND1 Gene

  • SCAN Domain Containing 1 2 3 5
  • SDP1 3 4
  • SCAN Domain-Containing Protein 1 3
  • SCAN-Related Protein RAZ1 3
  • SCAN Domain-Containing 1 2
  • RAZ1 3

External Ids for SCAND1 Gene

Previous GeneCards Identifiers for SCAND1 Gene

  • GC20M034231
  • GC20M035209
  • GC20M035256
  • GC20M034004
  • GC20M034542
  • GC20M031319

Summaries for SCAND1 Gene

Entrez Gene Summary for SCAND1 Gene

  • This gene encodes a SCAN box domain-containing protein. The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. This protein binds to and may regulate the function of the transcription factor myeloid zinc finger 1B. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]

GeneCards Summary for SCAND1 Gene

SCAND1 (SCAN Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is ZSCAN25.

UniProtKB/Swiss-Prot for SCAND1 Gene

  • May regulate transcriptional activity.

Gene Wiki entry for SCAND1 Gene

Additional gene information for SCAND1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAND1 Gene

Genomics for SCAND1 Gene

Regulatory Elements for SCAND1 Gene

Enhancers for SCAND1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H035739 3.1 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +217.7 217749 7 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D CPNE1 RBM12 RBM39 ERGIC3 AAR2 PHF20 EIF6 TRPC4AP RPL36P4 MYL9
GH20H036049 1.2 ENCODE 4.5 -91.6 -91637 2.6 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CPNE1 MYL9 CNBD2 AAR2 SCAND1 GC20M036049 ENSG00000277235
GH20H035795 1.4 FANTOM5 Ensembl ENCODE dbSUPER 2.9 +162.7 162672 3.5 TAL1 HLF ZNF507 CPNE1 PHF20 RBM12 NCOA6 SPAG4 RBM39 SCAND1 GC20M035824
GH20H035977 1.3 FANTOM5 Ensembl ENCODE 0.4 -18.8 -18821 0.6 HDAC1 BACH1 CEBPG IRF9 ZNF316 NFE2 ATF7 TRIM24 MAFK HLF CPNE1 RBM39 SCAND1 GC20P036036
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCAND1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SCAND1 Gene

Genomic Locations for SCAND1 Gene
5,856 bases
Minus strand

Genomic View for SCAND1 Gene

Genes around SCAND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAND1 Gene

Proteins for SCAND1 Gene

  • Protein details for SCAND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SCAN domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6IAG7

    Protein attributes for SCAND1 Gene

    179 amino acids
    Molecular mass:
    19082 Da
    Quaternary structure:
    • Interacts with ZNF202.

neXtProt entry for SCAND1 Gene

Post-translational modifications for SCAND1 Gene

  • Ubiquitination at isoforms=144
  • Modification sites at PhosphoSitePlus

Other Protein References for SCAND1 Gene

No data available for DME Specific Peptides for SCAND1 Gene

Domains & Families for SCAND1 Gene

Gene Families for SCAND1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SCAND1 Gene

Suggested Antigen Peptide Sequences for SCAND1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SCAND1: view

No data available for UniProtKB/Swiss-Prot for SCAND1 Gene

Function for SCAND1 Gene

Molecular function for SCAND1 Gene

UniProtKB/Swiss-Prot Function:
May regulate transcriptional activity.

Phenotypes From GWAS Catalog for SCAND1 Gene

Gene Ontology (GO) - Molecular Function for SCAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding ISS --
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with SCAND1: view

Phenotypes for SCAND1 Gene

genes like me logo Genes that share phenotypes with SCAND1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCAND1 Gene

Localization for SCAND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAND1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAND1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with SCAND1: view

Pathways & Interactions for SCAND1 Gene

SuperPathways for SCAND1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SCAND1: view

No data available for Pathways by source and SIGNOR curated interactions for SCAND1 Gene

Drugs & Compounds for SCAND1 Gene

No Compound Related Data Available

Transcripts for SCAND1 Gene

Unigene Clusters for SCAND1 Gene

SCAN domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAND1 Gene

No ASD Table

Relevant External Links for SCAND1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCAND1 Gene

Protein differential expression in normal tissues from HIPED for SCAND1 Gene

This gene is overexpressed in Monocytes (56.8) and CD4 Tcells (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCAND1 Gene

Protein tissue co-expression partners for SCAND1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SCAND1 Gene:


SOURCE GeneReport for Unigene cluster for SCAND1 Gene:


Evidence on tissue expression from TISSUES for SCAND1 Gene

  • Nervous system(4.7)
  • Skin(4.4)
genes like me logo Genes that share expression patterns with SCAND1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAND1 Gene

Orthologs for SCAND1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCAND1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCAND1 33 34
  • 99.63 (n)
(Canis familiaris)
Mammalia SCAND1 33 34
  • 81.27 (n)
(Mus musculus)
Mammalia Scand1 33 16 34
  • 80.41 (n)
(Rattus norvegicus)
Mammalia Scand1 33
  • 79.58 (n)
(Bos Taurus)
Mammalia SCAND1 33 34
  • 77.34 (n)
(Monodelphis domestica)
Mammalia SCAND1 34
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 26 (a)
-- 34
  • 9 (a)
-- 34
  • 8 (a)
-- 34
  • 6 (a)
-- 34
  • 6 (a)
-- 34
  • 6 (a)
Species where no ortholog for SCAND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCAND1 Gene

Gene Tree for SCAND1 (if available)
Gene Tree for SCAND1 (if available)

Paralogs for SCAND1 Gene

Variants for SCAND1 Gene

Sequence variations from dbSNP and Humsavar for SCAND1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000417733 -- 35,954,855(+) GGGCT(C/T)GTTCG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000532386 -- 35,955,180(+) TGACT(C/G/T)AGCTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000623838 -- 35,955,404(+) TAAAA(A/T)CATTT intron-variant, upstream-variant-2KB
rs1001681897 -- 35,954,673(+) TCGAG(A/G)AGGAG intron-variant, upstream-variant-2KB, reference, missense
rs1001734465 -- 35,954,860(+) CGTTC(C/G)AGTGG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SCAND1 Gene

Variant ID Type Subtype PubMed ID
nsv833964 CNV loss 17160897
nsv526188 CNV gain 19592680
nsv522947 CNV gain 19592680
nsv1067230 CNV gain 25217958
nsv1066673 CNV loss 25217958

Variation tolerance for SCAND1 Gene

Gene Damage Index Score: 0.13; 2.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCAND1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAND1 Gene

Disorders for SCAND1 Gene

Relevant External Links for SCAND1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCAND1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAND1 Gene

Publications for SCAND1 Gene

  1. The SCAN domain mediates selective oligomerization. (PMID: 10747874) Schumacher C … Wagner S (The Journal of biological chemistry 2000) 2 3 4 60
  2. Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations. (PMID: 10777584) Sander TL … Morris JF (The Journal of biological chemistry 2000) 2 3 22 60
  3. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y … Boer JM (Journal of lipid research 2008) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain. (PMID: 12444922) Babb R … Bowen BR (The Biochemical journal 2003) 2 3 60

Products for SCAND1 Gene

Sources for SCAND1 Gene

Loading form....