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Aliases for SCAMP5 Gene

Aliases for SCAMP5 Gene

  • Secretory Carrier Membrane Protein 5 2 3 4 5
  • HSCAMP5 3 4
  • Secretory Carrier-Associated Membrane Protein 5 3

External Ids for SCAMP5 Gene

Previous GeneCards Identifiers for SCAMP5 Gene

  • GC15P071137
  • GC15P068402
  • GC15P072863
  • GC15P073003
  • GC15P073074
  • GC15P075287
  • GC15P052084

Summaries for SCAMP5 Gene

GeneCards Summary for SCAMP5 Gene

SCAMP5 (Secretory Carrier Membrane Protein 5) is a Protein Coding gene. An important paralog of this gene is SCAMP4.

UniProtKB/Swiss-Prot for SCAMP5 Gene

  • Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.

Gene Wiki entry for SCAMP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP5 Gene

Genomics for SCAMP5 Gene

Regulatory Elements for SCAMP5 Gene

Enhancers for SCAMP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G075034 1.7 FANTOM5 Ensembl ENCODE dbSUPER 60.2 +79.2 79219 4.2 HDGF PKNOX1 INSM2 SIN3A RAD21 GLIS2 EGR1 ZSCAN5C KLF7 ZNF548 SCAMP5 RPP25 ENSG00000260274 ENSG00000203392 MPI DNM1P34 C15orf39 CSK MAN2C1 CLK3
GH15G075041 2.1 FANTOM5 Ensembl ENCODE dbSUPER 40.9 +88.7 88668 8.2 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SCAMP5 C15orf39 RPP25 DNM1P35 ENSG00000203392 PPCDC EDC3 ULK3 SIN3A CSK
GH15G074995 1.6 FANTOM5 ENCODE dbSUPER 52.4 +38.8 38802 1.9 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A SLC30A9 ZNF766 ZNF143 ZHX2 SCAMP5 PPCDC DNM1P35 CPLX3 ULK3 GC15P074996 ENSG00000199580 GC15M074984
GH15G075028 1.5 Ensembl ENCODE dbSUPER 52.1 +73.4 73440 4.1 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF2 YY1 TCF12 GATA2 ZNF143 SCAMP5 FBXO22 DNM1P35 SNUPN EDC3 PTPN9 MIR631 ISLR PPCDC GC15P075113
GH15G075061 1.6 FANTOM5 Ensembl ENCODE dbSUPER 48.1 +104.7 104683 1.4 BACH1 MAX ZNF335 ZNF121 ARID3A POLR2A EED HNF4G RELB ZNF600 SCAMP5 C15orf39 RPP25 CSK SIN3A MAN2C1 CLK3 SCAMP2 PPCDC GC15P075113
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCAMP5 on UCSC Golden Path with GeneCards custom track

Promoters for SCAMP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000278352 -419 1201 CREB3L1 SIN3A YY1 ZNF207 ZNF263 SP3 ZHX2 REST SMARCB1 ZNF592
ENSR00000278351 881 201 POLR2A EZH2
ENSR00000079322 1281 201 ELF3 CTCF KLF1 ZNF792 SAP130 SUZ12 TAF1 DMAP1 ZIC2 POLR2A

Genomic Location for SCAMP5 Gene

Chromosome:
15
Start:
74,957,219 bp from pter
End:
75,021,496 bp from pter
Size:
64,278 bases
Orientation:
Plus strand

Genomic View for SCAMP5 Gene

Genes around SCAMP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP5 Gene

Proteins for SCAMP5 Gene

  • Protein details for SCAMP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAC9-SCAM5_HUMAN
    Recommended name:
    Secretory carrier-associated membrane protein 5
    Protein Accession:
    Q8TAC9
    Secondary Accessions:
    • B3KPJ7
    • B7Z762
    • D3DW71
    • Q8N3M4

    Protein attributes for SCAMP5 Gene

    Size:
    235 amino acids
    Molecular mass:
    26104 Da
    Quaternary structure:
    • Interacts (via C-terminal part) with SYT1 and SYT2; interaction with synaptotagmins making a link with the SNARE molecules. Interacts with SLC9A7.

    Alternative splice isoforms for SCAMP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAMP5 Gene

Post-translational modifications for SCAMP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCAMP5 Gene

Domains & Families for SCAMP5 Gene

Gene Families for SCAMP5 Gene

Protein Domains for SCAMP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAMP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAC9

UniProtKB/Swiss-Prot:

SCAM5_HUMAN :
  • Belongs to the SCAMP family. SCAMP5 subfamily.
Family:
  • Belongs to the SCAMP family. SCAMP5 subfamily.
genes like me logo Genes that share domains with SCAMP5: view

Function for SCAMP5 Gene

Molecular function for SCAMP5 Gene

UniProtKB/Swiss-Prot Function:
Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.
UniProtKB/Swiss-Prot Induction:
By endoplasmic reticulum stress.

Gene Ontology (GO) - Molecular Function for SCAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15840657
genes like me logo Genes that share ontologies with SCAMP5: view
genes like me logo Genes that share phenotypes with SCAMP5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCAMP5

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAMP5 Gene

Localization for SCAMP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP5 Gene

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAMP5 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
endosome 5

Gene Ontology (GO) - Cellular Components for SCAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 19234194
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IDA,IEA 19234194
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SCAMP5: view

Pathways & Interactions for SCAMP5 Gene

SuperPathways for SCAMP5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 exocytosis IEA --
GO:0015031 protein transport IEA --
GO:0034976 response to endoplasmic reticulum stress IDA 19240033
GO:0045806 negative regulation of endocytosis IDA 19240033
genes like me logo Genes that share ontologies with SCAMP5: view

No data available for Pathways by source and SIGNOR curated interactions for SCAMP5 Gene

Drugs & Compounds for SCAMP5 Gene

No Compound Related Data Available

Transcripts for SCAMP5 Gene

Unigene Clusters for SCAMP5 Gene

Secretory carrier membrane protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - -

Relevant External Links for SCAMP5 Gene

GeneLoc Exon Structure for
SCAMP5
ECgene alternative splicing isoforms for
SCAMP5

Expression for SCAMP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCAMP5 Gene

mRNA differential expression in normal tissues according to GTEx for SCAMP5 Gene

This gene is overexpressed in Brain - Cortex (x6.3), Brain - Frontal Cortex (BA9) (x5.7), Brain - Anterior cingulate cortex (BA24) (x5.1), and Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for SCAMP5 Gene

This gene is overexpressed in Retina (26.5), Frontal cortex (20.4), and Fetal Brain (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCAMP5 Gene



Protein tissue co-expression partners for SCAMP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCAMP5 Gene:

SCAMP5

SOURCE GeneReport for Unigene cluster for SCAMP5 Gene:

Hs.374180

mRNA Expression by UniProt/SwissProt for SCAMP5 Gene:

Q8TAC9-SCAM5_HUMAN
Tissue specificity: Expressed both by neuronal and non-neuronal tissues. Expressed in brain, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and in the different parts of brain. In thyroid tissues, it is expressed by the follicular epithelial cells. In the adrenal gland tissues it is detected in the zona fasciculata of the cortex region (at protein level).

Evidence on tissue expression from TISSUES for SCAMP5 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with SCAMP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAMP5 Gene

Orthologs for SCAMP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAMP5 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia SCAMP5 34 35
  • 94.18 (n)
cow
(Bos Taurus)
Mammalia SCAMP5 34 35
  • 92.91 (n)
mouse
(Mus musculus)
Mammalia Scamp5 34 16 35
  • 92.77 (n)
rat
(Rattus norvegicus)
Mammalia Scamp5 34
  • 92.06 (n)
oppossum
(Monodelphis domestica)
Mammalia SCAMP5 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCAMP5 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCAMP5 34 35
  • 83.69 (n)
lizard
(Anolis carolinensis)
Reptilia SCAMP5 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp4 34
  • 74.18 (n)
Str.2318 34
zebrafish
(Danio rerio)
Actinopterygii scamp5a 34 35
  • 75.65 (n)
SCAMP5 (2 of 2) 35
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Scamp 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scm-1 35
  • 27 (a)
OneToMany
Species where no ortholog for SCAMP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP5 Gene

ENSEMBL:
Gene Tree for SCAMP5 (if available)
TreeFam:
Gene Tree for SCAMP5 (if available)

Paralogs for SCAMP5 Gene

Paralogs for SCAMP5 Gene

genes like me logo Genes that share paralogs with SCAMP5: view

Variants for SCAMP5 Gene

Sequence variations from dbSNP and Humsavar for SCAMP5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000006556 -- 75,002,373(+) TACAC(A/G)TCTCT intron-variant
rs1000011863 -- 75,011,151(+) CCGTG(A/G)GCTGG intron-variant
rs1000157789 -- 75,007,906(+) TGTTA(C/G)CCAGG intron-variant
rs1000179850 -- 75,003,113(+) AGACA(C/G)AGTTT intron-variant
rs1000293069 -- 75,007,632(+) ACGAT(C/T)TCGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP5 Gene

Variant ID Type Subtype PubMed ID
nsv1116085 CNV deletion 24896259
nsv1121512 CNV deletion 24896259
nsv527237 CNV loss 19592680
nsv569993 CNV gain 21841781

Variation tolerance for SCAMP5 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCAMP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCAMP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP5 Gene

Disorders for SCAMP5 Gene

Relevant External Links for SCAMP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCAMP5

No disorders were found for SCAMP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAMP5 Gene

Publications for SCAMP5 Gene

  1. Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery. (PMID: 19234194) Han C. … Cao X. (J. Immunol. 2009) 3 4 64
  2. SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition. (PMID: 19240033) Noh J.-Y. … Jung Y.-K. (J. Biol. Chem. 2009) 3 4 64
  3. Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. (PMID: 15840657) Lin P.J. … Numata M. (J. Cell Sci. 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SCAMP5 Gene

Sources for SCAMP5 Gene

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