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Aliases for SCAMP5 Gene

Aliases for SCAMP5 Gene

  • Secretory Carrier Membrane Protein 5 2 3 4 5
  • HSCAMP5 3 4

External Ids for SCAMP5 Gene

Previous GeneCards Identifiers for SCAMP5 Gene

  • GC15P071137
  • GC15P068402
  • GC15P072863
  • GC15P073003
  • GC15P073074
  • GC15P075287
  • GC15P052084

Summaries for SCAMP5 Gene

GeneCards Summary for SCAMP5 Gene

SCAMP5 (Secretory Carrier Membrane Protein 5) is a Protein Coding gene. An important paralog of this gene is SCAMP3.

UniProtKB/Swiss-Prot for SCAMP5 Gene

  • Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.

Gene Wiki entry for SCAMP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP5 Gene

Genomics for SCAMP5 Gene

Regulatory Elements for SCAMP5 Gene

Enhancers for SCAMP5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCAMP5 on UCSC Golden Path with GeneCards custom track

Promoters for SCAMP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCAMP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCAMP5 Gene

Chromosome:
15
Start:
74,957,219 bp from pter
End:
75,021,496 bp from pter
Size:
64,278 bases
Orientation:
Plus strand

Genomic View for SCAMP5 Gene

Genes around SCAMP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP5 Gene

Proteins for SCAMP5 Gene

  • Protein details for SCAMP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAC9-SCAM5_HUMAN
    Recommended name:
    Secretory carrier-associated membrane protein 5
    Protein Accession:
    Q8TAC9
    Secondary Accessions:
    • B3KPJ7
    • B7Z762
    • D3DW71
    • Q8N3M4

    Protein attributes for SCAMP5 Gene

    Size:
    235 amino acids
    Molecular mass:
    26104 Da
    Quaternary structure:
    • Interacts (via C-terminal part) with SYT1 and SYT2; interaction with synaptotagmins making a link with the SNARE molecules. Interacts with SLC9A7.

    Alternative splice isoforms for SCAMP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAMP5 Gene

Proteomics data for SCAMP5 Gene at MOPED

Post-translational modifications for SCAMP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCAMP5 Gene

Domains & Families for SCAMP5 Gene

Gene Families for SCAMP5 Gene

Protein Domains for SCAMP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAMP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAC9

UniProtKB/Swiss-Prot:

SCAM5_HUMAN :
  • Belongs to the SCAMP family. SCAMP5 subfamily.
Family:
  • Belongs to the SCAMP family. SCAMP5 subfamily.
genes like me logo Genes that share domains with SCAMP5: view

Function for SCAMP5 Gene

Molecular function for SCAMP5 Gene

UniProtKB/Swiss-Prot Function:
Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.
UniProtKB/Swiss-Prot Induction:
By endoplasmic reticulum stress.
genes like me logo Genes that share phenotypes with SCAMP5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCAMP5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAMP5 Gene

Localization for SCAMP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP5 Gene

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCAMP5 Gene COMPARTMENTS Subcellular localization image for SCAMP5 gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SCAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
GO:0031201 colocalizes_with SNARE complex IDA 19234194
genes like me logo Genes that share ontologies with SCAMP5: view

Pathways & Interactions for SCAMP5 Gene

SuperPathways for SCAMP5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0045956 positive regulation of calcium ion-dependent exocytosis IDA 19234194
genes like me logo Genes that share ontologies with SCAMP5: view

No data available for Pathways by source and SIGNOR curated interactions for SCAMP5 Gene

Drugs & Compounds for SCAMP5 Gene

No Compound Related Data Available

Transcripts for SCAMP5 Gene

Unigene Clusters for SCAMP5 Gene

Secretory carrier membrane protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - -

Relevant External Links for SCAMP5 Gene

GeneLoc Exon Structure for
SCAMP5
ECgene alternative splicing isoforms for
SCAMP5

Expression for SCAMP5 Gene

mRNA expression in normal human tissues for SCAMP5 Gene

mRNA differential expression in normal tissues according to GTEx for SCAMP5 Gene

This gene is overexpressed in Brain - Cortex (x6.3), Brain - Frontal Cortex (BA9) (x5.7), Brain - Anterior cingulate cortex (BA24) (x5.1), and Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for SCAMP5 Gene

This gene is overexpressed in Retina (26.5), Frontal cortex (20.4), and Fetal Brain (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAMP5 Gene



SOURCE GeneReport for Unigene cluster for SCAMP5 Gene Hs.374180

mRNA Expression by UniProt/SwissProt for SCAMP5 Gene

Q8TAC9-SCAM5_HUMAN
Tissue specificity: Expressed both by neuronal and non-neuronal tissues. Expressed in brain, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and in the different parts of brain. In thyroid tissues, it is expressed by the follicular epithelial cells. In the adrenal gland tissues it is detected in the zona fasciculata of the cortex region (at protein level).
genes like me logo Genes that share expression patterns with SCAMP5: view

Protein tissue co-expression partners for SCAMP5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCAMP5 Gene

Orthologs for SCAMP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCAMP5 35
  • 92.91 (n)
  • 98.72 (a)
SCAMP5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCAMP5 35
  • 94.18 (n)
  • 98.3 (a)
SCAMP5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scamp5 35
  • 92.77 (n)
  • 98.72 (a)
Scamp5 16
Scamp5 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCAMP5 35
  • 99.57 (n)
  • 99.15 (a)
SCAMP5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scamp5 35
  • 92.06 (n)
  • 98.3 (a)
oppossum
(Monodelphis domestica)
Mammalia SCAMP5 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCAMP5 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCAMP5 35
  • 83.69 (n)
  • 91.49 (a)
SCAMP5 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAMP5 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp4 35
  • 74.18 (n)
  • 83.83 (a)
Str.2318 35
zebrafish
(Danio rerio)
Actinopterygii scamp5a 35
  • 75.65 (n)
  • 82.17 (a)
SCAMP5 (2 of 2) 36
  • 69 (a)
OneToMany
scamp5a 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Scamp 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scm-1 36
  • 27 (a)
OneToMany
Species with no ortholog for SCAMP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP5 Gene

ENSEMBL:
Gene Tree for SCAMP5 (if available)
TreeFam:
Gene Tree for SCAMP5 (if available)

Paralogs for SCAMP5 Gene

Paralogs for SCAMP5 Gene

genes like me logo Genes that share paralogs with SCAMP5: view

Variants for SCAMP5 Gene

Sequence variations from dbSNP and Humsavar for SCAMP5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs9161 -- 75,021,292(+) TGTAG(A/G)AAGGT nc-transcript-variant, utr-variant-3-prime
rs13056 -- 75,019,846(+) CAAGG(A/G)TGAGT nc-transcript-variant, utr-variant-3-prime
rs6495135 -- 75,002,689(+) TCGTG(C/T)CTCAT intron-variant
rs6495136 -- 75,003,123(+) tcact(C/G)tgttg intron-variant
rs6495137 -- 75,003,200(+) ttaca(A/G)gcgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP5 Gene

Variant ID Type Subtype PubMed ID
nsv527237 CNV Loss 19592680

Variation tolerance for SCAMP5 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCAMP5 Gene

Disorders for SCAMP5 Gene

Relevant External Links for SCAMP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCAMP5

No disorders were found for SCAMP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAMP5 Gene

Publications for SCAMP5 Gene

  1. SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition. (PMID: 19240033) Noh J.-Y. … Jung Y.-K. (J. Biol. Chem. 2009) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans D.M. … Whitfield J.B. (Hum. Mol. Genet. 2013) 3
  5. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PMID: 21163940) Soler-LA^pez M. … Aloy P. (Genome Res. 2011) 3

Products for SCAMP5 Gene

Sources for SCAMP5 Gene

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