Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SCAMP5 Gene

Aliases for SCAMP5 Gene

  • Secretory Carrier Membrane Protein 5 2 3 4
  • HSCAMP5 3 4
  • Secretory Carrier-Associated Membrane Protein 5 3

External Ids for SCAMP5 Gene

Previous GeneCards Identifiers for SCAMP5 Gene

  • GC15P071137
  • GC15P068402
  • GC15P072863
  • GC15P073003
  • GC15P073074
  • GC15P075287
  • GC15P052084

Summaries for SCAMP5 Gene

GeneCards Summary for SCAMP5 Gene

SCAMP5 (Secretory Carrier Membrane Protein 5) is a Protein Coding gene. An important paralog of this gene is SCAMP3.

UniProtKB/Swiss-Prot for SCAMP5 Gene

  • Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.

Gene Wiki entry for SCAMP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP5 Gene

Genomics for SCAMP5 Gene

Regulatory Elements for SCAMP5 Gene

Genomic Location for SCAMP5 Gene

Start:
74,957,219 bp from pter
End:
75,021,496 bp from pter
Size:
64,278 bases
Orientation:
Plus strand

Genomic View for SCAMP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCAMP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP5 Gene

Proteins for SCAMP5 Gene

  • Protein details for SCAMP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAC9-SCAM5_HUMAN
    Recommended name:
    Secretory carrier-associated membrane protein 5
    Protein Accession:
    Q8TAC9
    Secondary Accessions:
    • B3KPJ7
    • B7Z762
    • D3DW71
    • Q8N3M4

    Protein attributes for SCAMP5 Gene

    Size:
    235 amino acids
    Molecular mass:
    26104 Da
    Quaternary structure:
    • Interacts (via C-terminal part) with SYT1 and SYT2; interaction with synaptotagmins making a link with the SNARE molecules. Interacts with SLC9A7.

    Alternative splice isoforms for SCAMP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAMP5 Gene

Proteomics data for SCAMP5 Gene at MOPED

Post-translational modifications for SCAMP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCAMP5 Gene

Domains for SCAMP5 Gene

Gene Families for SCAMP5 Gene

HGNC:
  • SCAMP :Secretory carrier membrane proteins

Protein Domains for SCAMP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAMP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAC9

UniProtKB/Swiss-Prot:

SCAM5_HUMAN :
  • Q8TAC9
Family:
  • Belongs to the SCAMP family. SCAMP5 subfamily.
genes like me logo Genes that share domains with SCAMP5: view

Function for SCAMP5 Gene

Molecular function for SCAMP5 Gene

UniProtKB/Swiss-Prot Function: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.
UniProtKB/Swiss-Prot Induction: By endoplasmic reticulum stress.

Gene Ontology (GO) - Molecular Function for SCAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15840657
genes like me logo Genes that share ontologies with SCAMP5: view

Phenotypes for SCAMP5 Gene

GenomeRNAi human phenotypes for SCAMP5:
genes like me logo Genes that share phenotypes with SCAMP5: view

miRNA for SCAMP5 Gene

miRTarBase miRNAs that target SCAMP5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCAMP5 Gene

Localization for SCAMP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP5 Gene

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCAMP5 Gene COMPARTMENTS Subcellular localization image for SCAMP5 gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SCAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 19234194
GO:0005886 plasma membrane IDA 19234194
GO:0016021 integral component of membrane IDA 19234194
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SCAMP5: view

Pathways for SCAMP5 Gene

SuperPathways for SCAMP5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0015031 protein transport IEA --
GO:0034976 response to endoplasmic reticulum stress IDA 19240033
GO:0045806 negative regulation of endocytosis IDA 19240033
GO:0045956 positive regulation of calcium ion-dependent exocytosis IDA 19234194
genes like me logo Genes that share ontologies with SCAMP5: view

No data available for Pathways by source for SCAMP5 Gene

Transcripts for SCAMP5 Gene

Unigene Clusters for SCAMP5 Gene

Secretory carrier membrane protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - -

Relevant External Links for SCAMP5 Gene

GeneLoc Exon Structure for
SCAMP5
ECgene alternative splicing isoforms for
SCAMP5

Expression for SCAMP5 Gene

mRNA expression in normal human tissues for SCAMP5 Gene

mRNA differential expression in normal tissues according to GTEx for SCAMP5 Gene

This gene is overexpressed in Brain - Cortex (6.3), Brain - Frontal Cortex (BA9) (5.7), Brain - Anterior cingulate cortex (BA24) (5.1), and Brain - Cerebellum (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAMP5 Gene

SOURCE GeneReport for Unigene cluster for SCAMP5 Gene Hs.374180

mRNA Expression by UniProt/SwissProt for SCAMP5 Gene

Q8TAC9-SCAM5_HUMAN
Tissue specificity: Expressed both by neuronal and non-neuronal tissues. Expressed in brain, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and in the different parts of brain. In thyroid tissues, it is expressed by the follicular epithelial cells. In the adrenal gland tissues it is detected in the zona fasciculata of the cortex region (at protein level).
genes like me logo Genes that share expressions with SCAMP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCAMP5 Gene

Orthologs for SCAMP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAMP5 35
  • 99.57 (n)
  • 99.15 (a)
SCAMP5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCAMP5 35
  • 92.91 (n)
  • 98.72 (a)
SCAMP5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCAMP5 35
  • 94.18 (n)
  • 98.3 (a)
SCAMP5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scamp5 35
  • 92.77 (n)
  • 98.72 (a)
Scamp5 16
Scamp5 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCAMP5 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCAMP5 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scamp5 35
  • 92.06 (n)
  • 98.3 (a)
chicken
(Gallus gallus)
Aves SCAMP5 35
  • 83.69 (n)
  • 91.49 (a)
SCAMP5 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAMP5 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp4 35
  • 74.18 (n)
  • 83.83 (a)
Str.2318 35
zebrafish
(Danio rerio)
Actinopterygii SCAMP5 (2 of 2) 36
  • 69 (a)
OneToMany
scamp5a 35
  • 75.65 (n)
  • 82.17 (a)
scamp5a 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Scamp 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scm-1 36
  • 27 (a)
OneToMany
Species with no ortholog for SCAMP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP5 Gene

ENSEMBL:
Gene Tree for SCAMP5 (if available)
TreeFam:
Gene Tree for SCAMP5 (if available)

Paralogs for SCAMP5 Gene

Paralogs for SCAMP5 Gene

genes like me logo Genes that share paralogs with SCAMP5: view

Variants for SCAMP5 Gene

Sequence variations from dbSNP and Humsavar for SCAMP5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs9161 -- 75,021,292(+) TGTAG(A/G)AAGGT utr-variant-3-prime, nc-transcript-variant
rs13056 -- 75,019,846(+) CAAGG(A/G)TGAGT utr-variant-3-prime, nc-transcript-variant
rs2289582 -- 75,018,053(+) AGCTG(C/T)CTAGC intron-variant
rs2289583 -- 75,018,695(+) GGGAG(A/C)ACTGT intron-variant
rs3057655 -- 75,009,483(+) GTGTG(-/TG/TGT/TGTG)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP5 Gene

Variant ID Type Subtype PubMed ID
nsv527237 CNV Loss 19592680

Relevant External Links for SCAMP5 Gene

HapMap Linkage Disequilibrium report
SCAMP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP5 Gene

Disorders for SCAMP5 Gene

No disorders were found for SCAMP5 Gene.

No data available for UniProtKB/Swiss-Prot for SCAMP5 Gene

Publications for SCAMP5 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. (PMID: 15840657) Lin P.J. … Numata M. (J. Cell Sci. 2005) 3 4
  5. Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery. (PMID: 19234194) Han C. … Cao X. (J. Immunol. 2009) 3 4

Products for SCAMP5 Gene

Sources for SCAMP5 Gene

Back to Top

Content