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Aliases for SCAMP4 Gene

Aliases for SCAMP4 Gene

  • Secretory Carrier Membrane Protein 4 2 3 4
  • Secretory Carrier-Associated Membrane Protein 4 3
  • SCAMP-4 3

External Ids for SCAMP4 Gene

Summaries for SCAMP4 Gene

Entrez Gene Summary for SCAMP4 Gene

  • Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SCAMP4 Gene

SCAMP4 (Secretory Carrier Membrane Protein 4) is a Protein Coding gene. An important paralog of this gene is SCAMP3.

UniProtKB/Swiss-Prot for SCAMP4 Gene

  • Probably involved in membrane protein trafficking.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP4 Gene

Genomics for SCAMP4 Gene

Genomic Location for SCAMP4 Gene

Start:
1,905,214 bp from pter
End:
1,926,013 bp from pter
Size:
20,800 bases
Orientation:
Plus strand

Genomic View for SCAMP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCAMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP4 Gene

Regulatory Elements for SCAMP4 Gene

Proteins for SCAMP4 Gene

  • Protein details for SCAMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969E2-SCAM4_HUMAN
    Recommended name:
    Secretory carrier-associated membrane protein 4
    Protein Accession:
    Q969E2
    Secondary Accessions:
    • Q8N2N1
    • Q8NAV0

    Protein attributes for SCAMP4 Gene

    Size:
    229 amino acids
    Molecular mass:
    25728 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCAMP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAMP4 Gene

Proteomics data for SCAMP4 Gene at MOPED

Post-translational modifications for SCAMP4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys4 and Lys185

No data available for DME Specific Peptides for SCAMP4 Gene

Domains for SCAMP4 Gene

Gene Families for SCAMP4 Gene

HGNC:
  • SCAMP :Secretory carrier membrane proteins

Protein Domains for SCAMP4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAMP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969E2

UniProtKB/Swiss-Prot:

SCAM4_HUMAN
Family:
  • Belongs to the SCAMP family.:
    • Q969E2
genes like me logo Genes that share domains with SCAMP4: view

Function for SCAMP4 Gene

Molecular function for SCAMP4 Gene

UniProtKB/Swiss-Prot Function: Probably involved in membrane protein trafficking.

miRNA for SCAMP4 Gene

miRTarBase miRNAs that target SCAMP4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCAMP4 Gene

Localization for SCAMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCAMP4 Gene COMPARTMENTS Subcellular localization image for SCAMP4 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SCAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCAMP4: view

Pathways for SCAMP4 Gene

SuperPathways for SCAMP4 Gene

No Data Available

Interacting Proteins for SCAMP4 Gene

Gene Ontology (GO) - Biological Process for SCAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SCAMP4: view

No data available for Pathways by source for SCAMP4 Gene

Transcripts for SCAMP4 Gene

Unigene Clusters for SCAMP4 Gene

Secretory carrier membrane protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP4 Gene

No ASD Table

Relevant External Links for SCAMP4 Gene

GeneLoc Exon Structure for
SCAMP4
ECgene alternative splicing isoforms for
SCAMP4

Expression for SCAMP4 Gene

mRNA expression in normal human tissues for SCAMP4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAMP4 Gene

SOURCE GeneReport for Unigene cluster for SCAMP4 Gene Hs.144980

genes like me logo Genes that share expressions with SCAMP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCAMP4 Gene

Orthologs for SCAMP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAMP4 35
  • 97.93 (n)
  • 97.74 (a)
SCAMP4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCAMP4 35
  • 87.48 (n)
  • 88.65 (a)
SCAMP4 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCAMP4 35
  • 89.37 (n)
  • 93.01 (a)
SCAMP4 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scamp4 35
  • 82.82 (n)
  • 83.84 (a)
Scamp4 16
Scamp4 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCAMP4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCAMP4 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scamp4 35
  • 83.55 (n)
  • 85.15 (a)
chicken
(Gallus gallus)
Aves SCAMP4 35
  • 75.84 (n)
  • 75.55 (a)
SCAMP4 36
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii scamp4 35
  • 61.26 (n)
  • 60.96 (a)
scamp4 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Scamp 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scm-1 36
  • 27 (a)
OneToMany
Species with no ortholog for SCAMP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCAMP4 Gene

ENSEMBL:
Gene Tree for SCAMP4 (if available)
TreeFam:
Gene Tree for SCAMP4 (if available)

Paralogs for SCAMP4 Gene

Paralogs for SCAMP4 Gene

Selected SIMAP similar genes for SCAMP4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCAMP4: view

Variants for SCAMP4 Gene

Sequence variations from dbSNP and Humsavar for SCAMP4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8730 -- 1,925,943(-) CGAGG(A/G)GCCAC utr-variant-3-prime
rs1036592 -- 1,920,713(+) CTGCC(A/G)GCTCG intron-variant
rs1061826 -- 1,925,928(+) CCTCC(A/C)CCGCC utr-variant-3-prime
rs1061828 -- 1,925,971(+) TGTTA(C/T)GTGAA utr-variant-3-prime
rs1610104 -- 1,914,049(+) GTCCC(G/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP4 Gene

Variant ID Type Subtype PubMed ID
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
nsv910545 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
dgv3616n71 CNV Loss 21882294
nsv910566 CNV Gain+Loss 21882294
dgv3617n71 CNV Loss 21882294
nsv910569 CNV Loss 21882294
dgv3618n71 CNV Loss 21882294
nsv910579 CNV Gain 21882294
nsv910587 CNV Gain+Loss 21882294
nsv910588 CNV Loss 21882294
nsv518629 CNV Loss 19592680
esv2717853 CNV Deletion 23290073
nsv910589 CNV Gain+Loss 21882294
dgv3621n71 CNV Loss 21882294
esv2571215 CNV Insertion 19546169
esv2717854 CNV Deletion 23290073
esv2717855 CNV Deletion 23290073
esv2675682 CNV Deletion 23128226

Relevant External Links for SCAMP4 Gene

HapMap Linkage Disequilibrium report
SCAMP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP4 Gene

Disorders for SCAMP4 Gene

Relevant External Links for SCAMP4

Genetic Association Database (GAD)
SCAMP4
Human Genome Epidemiology (HuGE) Navigator
SCAMP4
genes like me logo Genes that share disorders with SCAMP4: view

No data available for UniProtKB/Swiss-Prot for SCAMP4 Gene

Publications for SCAMP4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for SCAMP4 Gene

  • antibodies-online peptides for SCAMP4
  • antibodies-online antibodies for SCAMP4
  • antibodies-online kits for SCAMP4

Sources for SCAMP4 Gene

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