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Aliases for SCAMP4 Gene

Aliases for SCAMP4 Gene

  • Secretory Carrier Membrane Protein 4 2 3 4 5
  • Secretory Carrier-Associated Membrane Protein 4 3
  • SCAMP-4 3

External Ids for SCAMP4 Gene

Previous GeneCards Identifiers for SCAMP4 Gene

  • GC19P001859
  • GC19P001860
  • GC19P001862
  • GC19P001676

Summaries for SCAMP4 Gene

Entrez Gene Summary for SCAMP4 Gene

  • Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SCAMP4 Gene

SCAMP4 (Secretory Carrier Membrane Protein 4) is a Protein Coding gene. An important paralog of this gene is SCAMP5.

UniProtKB/Swiss-Prot for SCAMP4 Gene

  • Probably involved in membrane protein trafficking.

Additional gene information for SCAMP4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP4 Gene

Genomics for SCAMP4 Gene

Regulatory Elements for SCAMP4 Gene

Enhancers for SCAMP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H001745 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.7 -156.8 -156764 5 HDGF PKNOX1 ARNT ZNF2 YY1 ZNF766 CBX5 FOS SP3 JUNB CIRBP SPPL2B AP3D1 SCAMP4 MUM1 LINC01775 SLC39A3 C19orf24 ATP8B3 REXO1
GH19H001202 1.7 Ensembl ENCODE dbSUPER 14.9 -698.5 -698458 7 ZFP64 FEZF1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC MEF2D ZNF610 CIRBP TMEM259 DAZAP1 LOC100288123 TCF3 PTBP1 GRIN3B POLRMT MIER2 DOT1L
GH19H001097 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -799.1 -799149 16 MLX DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 NR2C1 CIRBP TMEM259 GPX4 GRIN3B ENSG00000267283 LOC100288123 DAZAP1 ENSG00000261526 MED16 TCF3
GH19H001236 1.9 FANTOM5 ENCODE dbSUPER 11.3 -648.4 -648356 41 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZC3H11A SF3A2 TCF3 LOC100288123 MIER2 CIRBP TMEM259 DAZAP1 PTBP1 C19orf24 MUM1
GH19H001442 1.6 FANTOM5 ENCODE dbSUPER 11.3 -460.9 -460913 3 HDGF PKNOX1 ARNT SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 FOS APC2 SF3A2 RNA5SP462 C19orf24 DAZAP1 C19orf25 REEP6 PCSK4 CIRBP GRIN3B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCAMP4 on UCSC Golden Path with GeneCards custom track

Promoters for SCAMP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105769 286 1001 HDGF MLX ARNT ARID4B SIN3A YBX1 DMAP1 YY1 ZNF766 ZNF207

Genomic Location for SCAMP4 Gene

Chromosome:
19
Start:
1,905,214 bp from pter
End:
1,926,013 bp from pter
Size:
20,800 bases
Orientation:
Plus strand

Genomic View for SCAMP4 Gene

Genes around SCAMP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP4 Gene

Proteins for SCAMP4 Gene

  • Protein details for SCAMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969E2-SCAM4_HUMAN
    Recommended name:
    Secretory carrier-associated membrane protein 4
    Protein Accession:
    Q969E2
    Secondary Accessions:
    • Q8N2N1
    • Q8NAV0

    Protein attributes for SCAMP4 Gene

    Size:
    229 amino acids
    Molecular mass:
    25728 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCAMP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAMP4 Gene

Post-translational modifications for SCAMP4 Gene

  • Ubiquitination at Lys185
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCAMP4 Gene

Domains & Families for SCAMP4 Gene

Gene Families for SCAMP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SCAMP4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAMP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969E2

UniProtKB/Swiss-Prot:

SCAM4_HUMAN :
  • Belongs to the SCAMP family.
Family:
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP4: view

Function for SCAMP4 Gene

Molecular function for SCAMP4 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in membrane protein trafficking.

Phenotypes From GWAS Catalog for SCAMP4 Gene

genes like me logo Genes that share phenotypes with SCAMP4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCAMP4

CRISPR Products

miRNA for SCAMP4 Gene

miRTarBase miRNAs that target SCAMP4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SCAMP4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAMP4 Gene

Localization for SCAMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAMP4 gene
Compartment Confidence
plasma membrane 4
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Lipid droplets (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCAMP4: view

Pathways & Interactions for SCAMP4 Gene

SuperPathways for SCAMP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SCAMP4: view

No data available for Pathways by source and SIGNOR curated interactions for SCAMP4 Gene

Drugs & Compounds for SCAMP4 Gene

No Compound Related Data Available

Transcripts for SCAMP4 Gene

Unigene Clusters for SCAMP4 Gene

Secretory carrier membrane protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SCAMP4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP4 Gene

No ASD Table

Relevant External Links for SCAMP4 Gene

GeneLoc Exon Structure for
SCAMP4
ECgene alternative splicing isoforms for
SCAMP4

Expression for SCAMP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCAMP4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCAMP4 Gene



Protein tissue co-expression partners for SCAMP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCAMP4 Gene:

SCAMP4

SOURCE GeneReport for Unigene cluster for SCAMP4 Gene:

Hs.144980

Evidence on tissue expression from TISSUES for SCAMP4 Gene

  • Nervous system(4.9)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SCAMP4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAMP4 Gene

Orthologs for SCAMP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAMP4 33 34
  • 97.93 (n)
dog
(Canis familiaris)
Mammalia SCAMP4 33 34
  • 89.37 (n)
cow
(Bos Taurus)
Mammalia SCAMP4 33 34
  • 87.48 (n)
rat
(Rattus norvegicus)
Mammalia Scamp4 33
  • 83.55 (n)
mouse
(Mus musculus)
Mammalia Scamp4 33 16 34
  • 82.82 (n)
oppossum
(Monodelphis domestica)
Mammalia SCAMP4 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCAMP4 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCAMP4 33 34
  • 75.84 (n)
zebrafish
(Danio rerio)
Actinopterygii scamp4 33 34
  • 61.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta Scamp 34
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scm-1 34
  • 27 (a)
OneToMany
Species where no ortholog for SCAMP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCAMP4 Gene

ENSEMBL:
Gene Tree for SCAMP4 (if available)
TreeFam:
Gene Tree for SCAMP4 (if available)

Paralogs for SCAMP4 Gene

Paralogs for SCAMP4 Gene

(4) SIMAP similar genes for SCAMP4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCAMP4: view

Variants for SCAMP4 Gene

Sequence variations from dbSNP and Humsavar for SCAMP4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs730882213 Pathogenic 1,912,477(+) TGCCC(A/G)TGCCC intron-variant, reference, missense
rs1000061983 -- 1,905,920(+) TCCTC(A/G)TCGTT intron-variant
rs1000068178 -- 1,923,491(+) CTGAG(G/T)CCCTG intron-variant
rs1000075930 -- 1,925,425(+) GGACC(C/T)GTCAA utr-variant-3-prime
rs1000338738 -- 1,916,785(+) CCAGT(C/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP4 Gene

Variant ID Type Subtype PubMed ID
dgv1685n106 CNV deletion 24896259
esv2571215 CNV insertion 19546169
esv2675682 CNV deletion 23128226
esv2717853 CNV deletion 23290073
esv2717854 CNV deletion 23290073
esv2717855 CNV deletion 23290073
esv32942 CNV gain+loss 17666407
esv3643413 CNV loss 21293372
esv3893156 CNV loss 25118596
nsv1160560 CNV deletion 26073780
nsv1160561 CNV deletion 26073780
nsv470107 CNV loss 18288195
nsv518629 CNV loss 19592680
nsv953942 CNV deletion 24416366

Variation tolerance for SCAMP4 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCAMP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCAMP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP4 Gene

Disorders for SCAMP4 Gene

Relevant External Links for SCAMP4

Genetic Association Database (GAD)
SCAMP4
Human Genome Epidemiology (HuGE) Navigator
SCAMP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCAMP4

No disorders were found for SCAMP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAMP4 Gene

Publications for SCAMP4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for SCAMP4 Gene

Sources for SCAMP4 Gene

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