SCAMP4 Gene
protein-coding GIFtS: 43
GCID: GC19P001905
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secretory carrier membrane protein 4
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Aliases for SCAMP4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Secretory Carrier Membrane Protein 41 2 3 | | FLJ338471 | | SCAMP-42 | | Secretory Carrier-Associated Membrane Protein 42 |
Export aliases for SCAMP4 gene to outside databasesPrevious GC identifers: GC19P001859 GC19P001860 GC19P001862 GC19P001676 |
Summaries for SCAMP4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for SCAMP4: Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membranetrafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 centraltransmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that ismediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely tofunction in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 (PubMed 11050114)).(supplied by OMIM, Feb 2011) UniProtKB/Swiss-Prot: SCAM4_HUMAN, Q969E2Function: Probably involved in membrane protein trafficking (By similarity)
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Genomic Views for SCAMP4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SCAMP4 gene promoter: Max1 Pax-5 Tal-1 Olf-1 E47 Max ZID c-Myc ATF Other transcription factors
Search SABiosciences Chromatin IP Primers for SCAMP4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAMP4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3SCAMP4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P001905: view genomic region
(about GC identifiers)
Start:
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1,905,213 bp from pter |
End:
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1,926,016 bp from pter |
Size:
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20,804 bases |
Orientation:
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plus strand |
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Proteins for SCAMP4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SCAM4_HUMAN, Q969E2 (See
protein sequence)Recommended Name: Secretory carrier-associated membrane protein 4 Size: 229 amino acids; 25728 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q8N2N1 Q8NAV0Alternative splicing: 3 isoforms: Q969E2-1 Q969E2-2 Q969E2-3 Explore the universe of human proteins at neXtProt for SCAMP4: NX_Q969E2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969E2 SCAMP4 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_524558.1 ENSEMBL proteins: ENSP00000316007 ENSP00000386865 ENSP00000388185 ENSP00000465199 Human Recombinant Protein Products for SCAMP4:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- | | GO:0030133 | transport vesicle |
-- | -- |
SCAMP4 for ontologies About GeneDecksing
SCAMP4 Antibody Products: Assay Products for SCAMP4: |
Protein
Domains / Families for SCAMP4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCAMP4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q969E2ProtoNet protein and cluster: Q969E2 UniProtKB/Swiss-Prot: SCAM4_HUMAN, Q969E2Similarity: Belongs to the SCAMP family |
Function for SCAMP4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: SCAM4_HUMAN, Q969E2Function: Probably involved in membrane protein trafficking (By similarity)Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCAMP4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAMP4 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SCAMP4 (NM_079834) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCAMP4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAMP4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAMP4 |
|
Pathways & Interactions for SCAMP4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCAMP4
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 2 Interacting proteins for SCAMP4 (ENSP000003160074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- |
SCAMP4 for ontologies About GeneDecksing
|
Drugs & Compounds for SCAMP4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SCAMP4 Search CenterWatch for drugs/clinical trials and news about SCAMP4 / SCAM4 
|
Transcripts for SCAMP4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SCAMP4 gene: NM_079834.2 Unigene Cluster for SCAMP4: Secretory carrier membrane protein 4 Hs.144980 [show with all ESTs]Unigene Representative Sequence: BC06259812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000316097(uc002luj.3 uc002luk.3 uc010dss.3) ENST00000452128(uc002lui.1) ENST00000414057 ENST00000460767 ENST00000489554 ENST00000588555 ENST00000409472 ENST00000411971 ENST00000588907 ENST00000590266 ENST00000585335 ENST00000472442
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCAMP4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAMP4 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SCAMP4 (NM_079834) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SCAMP4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAMP4  |
Additional cDNA sequence: AF109187.1 AF173896.1 AK074967.1 AK092056.1 AK126544.1 AK307641.1 AK307700.1 AL832731.1 BC007958.2 BC011747.2 BC011824.1 BC016509.1 BC016685.1 BC062598.1 BX647235.1 17 DOTS entries: DT.315460 DT.121428532 DT.91725809 DT.100802577 DT.40314413 DT.121428533 DT.100781213 DT.91749470 DT.99942447 DT.121428529 DT.100781214 DT.121428537 DT.121428554 DT.97812873 DT.121428543 DT.121428546 DT.40195006 24/362 AceView cDNA sequences (see all 362): BX647235 AI208430 AI470071 BE207068 BM848312 NM_138422 BC012080 BU844505 AA232686 BI771011 AI792654 BM714166 BU542053 BM044653 BE781053 BM703621 AL597181 CK823425 BU541753 NM_079834 BX107559 BP364510 BM713797 AI017809 GeneLoc Exon Structure
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Expression for SCAMP4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCAMP4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTTCTGCACT
 About this image See SCAMP4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SCAMP4
SOURCE GeneReport for Unigene cluster: Hs.144980 SABiosciences Custom PCR Arrays for SCAMP4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCAMP4 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SCAMP4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCAMP4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCAMP4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAMP4 |
Orthologs for SCAMP4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SCAMP4 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for SCAMP4 (if available) TreeFam Gene Tree for SCAMP4 (if available)  |
Paralogs for SCAMP4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SCAMP4 gene
- SCAMP32 SCAMP22 SCAMP52
4 SIMAP similar genes for SCAMP4 using alignment to 3 protein entries: SCAM4_HUMAN (see all proteins):SCAMP2 SCAMP5 SCAMP1 SCAMP3
SCAMP4 for paralogs About GeneDecksing
|
Genomic Variants for SCAMP4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 19 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SCAMP4 (1905213 - 1926016 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for SCAMP4 3 CNVs: 30062 7191 30063 2 Indels: 102765 40252  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCAMP4 |
|
Disorders
/ Diseases for SCAMP4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCAMP4 for disorders About MalaCards
SCAMP4 for disorders About GeneDecksing
OMIM gene information: 613764
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: SCAMP4 (1 document) Export disorders for SCAMP4 gene to outside databases
|
Publications for SCAMP4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCAMP4 gene, integrated from 9 sources (see all 13): (articles sorted by number of sources associating them with SCAMP4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
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External Searches for SCAMP4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing SCAMP4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCAMP4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCAMP4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SCAMP4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SCAMP4 gene: Search GeneIP for patents involving SCAMP4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SCAMP4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
| | | | OriGene Antibodies for SCAMP4 | | OriGene shRNA RFP for SCAMP4 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCAMP4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCAMP4 | | OriGene Protein Over-expression Lysate for SCAMP4 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for SCAMP4 | | OriGene 3'-UTR Clone for SCAMP4 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAMP4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCAMP4 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for SCAMP4 | | OriGene Custom Protein Services for SCAMP4 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCAMP4 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCAMP4 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAMP4 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCAMP4 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCAMP4 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCAMP4 |
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| | | Search Tocris compounds for SCAMP4 |
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 | | SCAMP4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAMP4 |
|  |  |  |  | | | ThermoFisher Antibodies for SCAMP4 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAMP4 |
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