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Aliases for SCAMP4 Gene

Aliases for SCAMP4 Gene

  • Secretory Carrier Membrane Protein 4 2 3 4 5
  • SCAMP-4 3

External Ids for SCAMP4 Gene

Previous GeneCards Identifiers for SCAMP4 Gene

  • GC19P001859
  • GC19P001860
  • GC19P001862
  • GC19P001676

Summaries for SCAMP4 Gene

Entrez Gene Summary for SCAMP4 Gene

  • Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SCAMP4 Gene

SCAMP4 (Secretory Carrier Membrane Protein 4) is a Protein Coding gene. An important paralog of this gene is SCAMP3.

UniProtKB/Swiss-Prot for SCAMP4 Gene

  • Probably involved in membrane protein trafficking.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP4 Gene

Genomics for SCAMP4 Gene

Regulatory Elements for SCAMP4 Gene

Enhancers for SCAMP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCAMP4 on UCSC Golden Path with GeneCards custom track

Promoters for SCAMP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCAMP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCAMP4 Gene

1,905,214 bp from pter
1,926,013 bp from pter
20,800 bases
Plus strand

Genomic View for SCAMP4 Gene

Genes around SCAMP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP4 Gene

Proteins for SCAMP4 Gene

  • Protein details for SCAMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secretory carrier-associated membrane protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8N2N1
    • Q8NAV0

    Protein attributes for SCAMP4 Gene

    229 amino acids
    Molecular mass:
    25728 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCAMP4 Gene


neXtProt entry for SCAMP4 Gene

Proteomics data for SCAMP4 Gene at MOPED

Post-translational modifications for SCAMP4 Gene

  • Ubiquitination at Lys 185
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SCAMP4

No data available for DME Specific Peptides for SCAMP4 Gene

Domains & Families for SCAMP4 Gene

Gene Families for SCAMP4 Gene

Protein Domains for SCAMP4 Gene


Suggested Antigen Peptide Sequences for SCAMP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SCAMP family.
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP4: view

Function for SCAMP4 Gene

Molecular function for SCAMP4 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in membrane protein trafficking.
genes like me logo Genes that share phenotypes with SCAMP4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCAMP4

miRNA for SCAMP4 Gene

miRTarBase miRNAs that target SCAMP4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAMP4 Gene

Localization for SCAMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SCAMP4 Gene COMPARTMENTS Subcellular localization image for SCAMP4 gene
Compartment Confidence
plasma membrane 4
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SCAMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCAMP4: view

Pathways & Interactions for SCAMP4 Gene

SuperPathways for SCAMP4 Gene

No Data Available

Interacting Proteins for SCAMP4 Gene

Gene Ontology (GO) - Biological Process for SCAMP4 Gene


No data available for Pathways by source and SIGNOR curated interactions for SCAMP4 Gene

Drugs & Compounds for SCAMP4 Gene

No Compound Related Data Available

Transcripts for SCAMP4 Gene

Unigene Clusters for SCAMP4 Gene

Secretory carrier membrane protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP4 Gene

No ASD Table

Relevant External Links for SCAMP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAMP4 Gene

mRNA expression in normal human tissues for SCAMP4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAMP4 Gene

SOURCE GeneReport for Unigene cluster for SCAMP4 Gene Hs.144980

genes like me logo Genes that share expression patterns with SCAMP4: view

Protein tissue co-expression partners for SCAMP4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCAMP4 Gene

Orthologs for SCAMP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCAMP4 35
  • 87.48 (n)
  • 88.65 (a)
  • 88 (a)
(Canis familiaris)
Mammalia SCAMP4 35
  • 89.37 (n)
  • 93.01 (a)
  • 93 (a)
(Mus musculus)
Mammalia Scamp4 35
  • 82.82 (n)
  • 83.84 (a)
Scamp4 16
Scamp4 36
  • 83 (a)
(Pan troglodytes)
Mammalia SCAMP4 35
  • 97.93 (n)
  • 97.74 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Scamp4 35
  • 83.55 (n)
  • 85.15 (a)
(Monodelphis domestica)
Mammalia SCAMP4 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SCAMP4 36
  • 72 (a)
(Gallus gallus)
Aves SCAMP4 35
  • 75.84 (n)
  • 75.55 (a)
  • 76 (a)
(Danio rerio)
Actinopterygii scamp4 35
  • 61.26 (n)
  • 60.96 (a)
scamp4 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Scamp 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea scm-1 36
  • 27 (a)
Species with no ortholog for SCAMP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SCAMP4 Gene

Gene Tree for SCAMP4 (if available)
Gene Tree for SCAMP4 (if available)

Paralogs for SCAMP4 Gene

Paralogs for SCAMP4 Gene

(4) SIMAP similar genes for SCAMP4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCAMP4: view

Variants for SCAMP4 Gene

Sequence variations from dbSNP and Humsavar for SCAMP4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs45562539 - 1,918,135(+) ACTGC(A/G)CCACC reference, missense
rs7259201 -- 1,926,028(+) CTGCC(A/G)CGTTT downstream-variant-500B
rs7259322 -- 1,922,940(+) TTGGT(C/G)GTCCT intron-variant
rs7259772 -- 1,926,484(+) tgggc(A/G)gatca downstream-variant-500B
rs12978628 -- 1,923,827(+) tcacc(A/G)tgtta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP4 Gene

Variant ID Type Subtype PubMed ID
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
nsv910545 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
dgv3616n71 CNV Loss 21882294
nsv910566 CNV Gain+Loss 21882294
dgv3617n71 CNV Loss 21882294
nsv910569 CNV Loss 21882294
dgv3618n71 CNV Loss 21882294
nsv910579 CNV Gain 21882294
nsv910587 CNV Gain+Loss 21882294
nsv910588 CNV Loss 21882294
nsv518629 CNV Loss 19592680
esv2717853 CNV Deletion 23290073
nsv910589 CNV Gain+Loss 21882294
dgv3621n71 CNV Loss 21882294
esv2571215 CNV Insertion 19546169
esv2717854 CNV Deletion 23290073
esv2717855 CNV Deletion 23290073
esv2675682 CNV Deletion 23128226

Variation tolerance for SCAMP4 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCAMP4 Gene

Disorders for SCAMP4 Gene

Relevant External Links for SCAMP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCAMP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAMP4 Gene

Publications for SCAMP4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for SCAMP4 Gene

Sources for SCAMP4 Gene