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Aliases for SCAMP3 Gene

Aliases for SCAMP3 Gene

  • Secretory Carrier Membrane Protein 3 2 3 4 5
  • Propin 1 2 3
  • C1orf3 3 4
  • PROPIN1 4

External Ids for SCAMP3 Gene

Previous HGNC Symbols for SCAMP3 Gene

  • C1orf3

Previous GeneCards Identifiers for SCAMP3 Gene

  • GC01M153083
  • GC01M150966
  • GC01M152003
  • GC01M152442
  • GC01M152038
  • GC01M153494
  • GC01M155225
  • GC01M126588

Summaries for SCAMP3 Gene

Entrez Gene Summary for SCAMP3 Gene

  • This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for SCAMP3 Gene

SCAMP3 (Secretory Carrier Membrane Protein 3) is a Protein Coding gene. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is SCAMP5.

UniProtKB/Swiss-Prot for SCAMP3 Gene

  • Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Gene Wiki entry for SCAMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP3 Gene

Genomics for SCAMP3 Gene

Regulatory Elements for SCAMP3 Gene

Enhancers for SCAMP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCAMP3 on UCSC Golden Path with GeneCards custom track

Promoters for SCAMP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCAMP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCAMP3 Gene

155,255,979 bp from pter
155,262,434 bp from pter
6,456 bases
Minus strand

Genomic View for SCAMP3 Gene

Genes around SCAMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP3 Gene

Proteins for SCAMP3 Gene

  • Protein details for SCAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secretory carrier-associated membrane protein 3
    Protein Accession:
    Secondary Accessions:
    • A9Z1W6
    • B1AVS6
    • O15128
    • Q96FR8
    • Q9BPY0

    Protein attributes for SCAMP3 Gene

    347 amino acids
    Molecular mass:
    38287 Da
    Quaternary structure:
    • Interacts with NEDD4, NEDD4L and TSG101. Interacts with RNF126.

    Alternative splice isoforms for SCAMP3 Gene


neXtProt entry for SCAMP3 Gene

Proteomics data for SCAMP3 Gene at MOPED

Post-translational modifications for SCAMP3 Gene

Other Protein References for SCAMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SCAMP3

No data available for DME Specific Peptides for SCAMP3 Gene

Domains & Families for SCAMP3 Gene

Gene Families for SCAMP3 Gene

Protein Domains for SCAMP3 Gene


Suggested Antigen Peptide Sequences for SCAMP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SCAMP family.
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP3: view

Function for SCAMP3 Gene

Molecular function for SCAMP3 Gene

GENATLAS Biochemistry:
secretory carrier membrane protein 3,widely expressed,as component of post-Golgi membranes,homolog of rat secretory carrier membrane protein 37 (SCAMP37),involved in cell surface recycling
UniProtKB/Swiss-Prot Function:
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Phenotypes for SCAMP3 Gene

genes like me logo Genes that share phenotypes with SCAMP3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCAMP3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAMP3 Gene

Localization for SCAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SCAMP3 Gene COMPARTMENTS Subcellular localization image for SCAMP3 gene
Compartment Confidence
extracellular 5
golgi apparatus 3
plasma membrane 3
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SCAMP3: view

Pathways & Interactions for SCAMP3 Gene

SuperPathways for SCAMP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032526 response to retinoic acid IEA --
genes like me logo Genes that share ontologies with SCAMP3: view

No data available for Pathways by source and SIGNOR curated interactions for SCAMP3 Gene

Drugs & Compounds for SCAMP3 Gene

No Compound Related Data Available

Transcripts for SCAMP3 Gene

Unigene Clusters for SCAMP3 Gene

Secretory carrier membrane protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ·
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - -
SP16: -
SP17: - - - - - - - - -
SP18: - - - - - - - - - - -

ExUns: 9c ^ 10a · 10b · 10c · 10d

Relevant External Links for SCAMP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAMP3 Gene

mRNA expression in normal human tissues for SCAMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCAMP3 Gene

This gene is overexpressed in Nasal epithelium (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAMP3 Gene

SOURCE GeneReport for Unigene cluster for SCAMP3 Gene Hs.200600

mRNA Expression by UniProt/SwissProt for SCAMP3 Gene

Tissue specificity: Widely expressed, with highest expression in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with SCAMP3: view

Protein tissue co-expression partners for SCAMP3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SCAMP3 Gene

Orthologs for SCAMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCAMP3 35
  • 92.51 (n)
  • 94.24 (a)
  • 94 (a)
(Canis familiaris)
Mammalia SCAMP3 35
  • 92.89 (n)
  • 96.54 (a)
  • 89 (a)
(Mus musculus)
Mammalia Scamp3 35
  • 88.18 (n)
  • 90.2 (a)
Scamp3 16
Scamp3 36
  • 90 (a)
(Pan troglodytes)
Mammalia SCAMP3 35
  • 99.9 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Scamp3 35
  • 87.51 (n)
  • 87.9 (a)
(Monodelphis domestica)
Mammalia SCAMP3 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
(Gallus gallus)
Aves SCAMP3 36
  • 79 (a)
(Anolis carolinensis)
Reptilia SCAMP3 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp3 35
  • 71.16 (n)
  • 75.37 (a)
Str.1919 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12686 35
(Danio rerio)
Actinopterygii scamp3 35
  • 64.57 (n)
  • 61.98 (a)
scamp3 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Scamp 37
  • 42 (a)
Scamp 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea scm-1 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8273 36
  • 46 (a)
Species with no ortholog for SCAMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP3 Gene

Gene Tree for SCAMP3 (if available)
Gene Tree for SCAMP3 (if available)

Paralogs for SCAMP3 Gene

Paralogs for SCAMP3 Gene

(4) SIMAP similar genes for SCAMP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCAMP3: view

Variants for SCAMP3 Gene

Sequence variations from dbSNP and Humsavar for SCAMP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_011885 -
VAR_011886 -
VAR_011887 -
VAR_011888 -

Structural Variations from Database of Genomic Variants (DGV) for SCAMP3 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850
nsv470741 CNV Loss 18288195
nsv872457 CNV Loss 21882294
nsv831636 CNV Loss 17160897
esv33869 CNV Loss 17666407
esv23319 CNV Gain 19812545
nsv436027 CNV Insertion 17901297

Variation tolerance for SCAMP3 Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCAMP3 Gene

Disorders for SCAMP3 Gene

Relevant External Links for SCAMP3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCAMP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAMP3 Gene

Publications for SCAMP3 Gene

  1. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. (PMID: 9331372) Winfield S.L. … Sidransky E. (Genome Res. 1997) 2 3 4 67
  2. Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor. (PMID: 9658162) Wu T.T. … Castle J.D. (Mol. Biol. Cell 1998) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SCAMP3 Gene

Sources for SCAMP3 Gene