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Aliases for SCAMP3 Gene

Aliases for SCAMP3 Gene

  • Secretory Carrier Membrane Protein 3 2 3 4
  • Propin 1 2 3
  • PROPIN1 4 6
  • C1orf3 3 4
  • Secretory Carrier-Associated Membrane Protein 3 3

External Ids for SCAMP3 Gene

Previous HGNC Symbols for SCAMP3 Gene

  • C1orf3

Previous GeneCards Identifiers for SCAMP3 Gene

  • GC01M153083
  • GC01M150966
  • GC01M152003
  • GC01M152442
  • GC01M152038
  • GC01M153494
  • GC01M155225
  • GC01M126588

Summaries for SCAMP3 Gene

Entrez Gene Summary for SCAMP3 Gene

  • This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for SCAMP3 Gene

SCAMP3 (Secretory Carrier Membrane Protein 3) is a Protein Coding gene. An important paralog of this gene is SCAMP5.

UniProtKB/Swiss-Prot for SCAMP3 Gene

  • Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface

Gene Wiki entry for SCAMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP3 Gene

Genomics for SCAMP3 Gene

Regulatory Elements for SCAMP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCAMP3 Gene

Start:
155,255,979 bp from pter
End:
155,262,430 bp from pter
Size:
6,452 bases
Orientation:
Minus strand

Genomic View for SCAMP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP3 Gene

Proteins for SCAMP3 Gene

  • Protein details for SCAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14828-SCAM3_HUMAN
    Recommended name:
    Secretory carrier-associated membrane protein 3
    Protein Accession:
    O14828
    Secondary Accessions:
    • A9Z1W6
    • B1AVS6
    • O15128
    • Q96FR8
    • Q9BPY0

    Protein attributes for SCAMP3 Gene

    Size:
    347 amino acids
    Molecular mass:
    38287 Da
    Quaternary structure:
    • Interacts with NEDD4, NEDD4L and TSG101. Interacts with RNF126.

    Alternative splice isoforms for SCAMP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAMP3 Gene

Proteomics data for SCAMP3 Gene at MOPED

Post-translational modifications for SCAMP3 Gene

Other Protein References for SCAMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCAMP3 Gene

Domains for SCAMP3 Gene

Gene Families for SCAMP3 Gene

HGNC:
  • SCAMP :Secretory carrier membrane proteins

Protein Domains for SCAMP3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAMP3 Gene

Graphical View of Domain Structure for InterPro Entry

O14828

UniProtKB/Swiss-Prot:

SCAM3_HUMAN :
  • O14828
Family:
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP3: view

Function for SCAMP3 Gene

Molecular function for SCAMP3 Gene

GENATLAS Biochemistry: secretory carrier membrane protein 3,widely expressed,as component of post-Golgi membranes,homolog of rat secretory carrier membrane protein 37 (SCAMP37),involved in cell surface recycling
UniProtKB/Swiss-Prot Function: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface

Gene Ontology (GO) - Molecular Function for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IPI 23418353
genes like me logo Genes that share ontologies with SCAMP3: view

Phenotypes for SCAMP3 Gene

GenomeRNAi human phenotypes for SCAMP3:
genes like me logo Genes that share phenotypes with SCAMP3: view

Animal Model Products

CRISPR Products

miRNA for SCAMP3 Gene

miRTarBase miRNAs that target SCAMP3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCAMP3 Gene

Localization for SCAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCAMP3 Gene COMPARTMENTS Subcellular localization image for SCAMP3 gene
Compartment Confidence
plasma membrane 3
endosome 2
golgi apparatus 2
cytoskeleton 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SCAMP3: view

Pathways for SCAMP3 Gene

SuperPathways for SCAMP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport TAS 9378760
GO:0010033 response to organic substance --
GO:0015031 protein transport IEA --
GO:0032526 response to retinoic acid IEA --
genes like me logo Genes that share ontologies with SCAMP3: view

No data available for Pathways by source for SCAMP3 Gene

Transcripts for SCAMP3 Gene

Unigene Clusters for SCAMP3 Gene

Secretory carrier membrane protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCAMP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ·
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - -
SP16: -
SP17: - - - - - - - - -
SP18: - - - - - - - - - - -
SP19:

ExUns: 9c ^ 10a · 10b · 10c · 10d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for SCAMP3 Gene

GeneLoc Exon Structure for
SCAMP3
ECgene alternative splicing isoforms for
SCAMP3

Expression for SCAMP3 Gene

mRNA expression in normal human tissues for SCAMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAMP3 Gene

SOURCE GeneReport for Unigene cluster for SCAMP3 Gene Hs.200600

mRNA Expression by UniProt/SwissProt for SCAMP3 Gene

O14828-SCAM3_HUMAN
Tissue specificity: Widely expressed, with highest expression in heart and skeletal muscle
genes like me logo Genes that share expressions with SCAMP3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SCAMP3 Gene

Orthologs for SCAMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAMP3 35
  • 99.9 (n)
  • 100 (a)
SCAMP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCAMP3 35
  • 92.51 (n)
  • 94.24 (a)
SCAMP3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCAMP3 35
  • 92.89 (n)
  • 96.54 (a)
SCAMP3 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scamp3 35
  • 88.18 (n)
  • 90.2 (a)
Scamp3 16
Scamp3 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCAMP3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Scamp3 35
  • 87.51 (n)
  • 87.9 (a)
chicken
(Gallus gallus)
Aves SCAMP3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAMP3 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12686 35
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp3 35
  • 71.16 (n)
  • 75.37 (a)
Str.1919 35
zebrafish
(Danio rerio)
Actinopterygii scamp3 35
  • 64.57 (n)
  • 61.98 (a)
scamp3 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Scamp 36
  • 41 (a)
OneToMany
Scamp 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea scm-1 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8273 36
  • 46 (a)
OneToMany
Species with no ortholog for SCAMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP3 Gene

ENSEMBL:
Gene Tree for SCAMP3 (if available)
TreeFam:
Gene Tree for SCAMP3 (if available)

Paralogs for SCAMP3 Gene

Paralogs for SCAMP3 Gene

Selected SIMAP similar genes for SCAMP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCAMP3: view

Variants for SCAMP3 Gene

Sequence variations from dbSNP and Humsavar for SCAMP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs760073 - 155,261,688(-) CACGC(G/T)TGACG missense, reference, intron-variant
rs760074 -- 155,260,714(-) AGACT(A/C)TAGAT intron-variant
rs1046188 -- 155,262,283(-) GGTCG(A/G)TGGAA utr-variant-5-prime
rs1076555 -- 155,260,663(+) GGCTG(C/T)TGAGG intron-variant
rs1142287 -- 155,260,340(-) CTGGG(A/G)GGCAC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for SCAMP3 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850
nsv470741 CNV Loss 18288195
nsv872457 CNV Loss 21882294
nsv831636 CNV Loss 17160897
esv33869 CNV Loss 17666407
esv23319 CNV Gain 19812545
nsv436027 CNV Insertion 17901297

Relevant External Links for SCAMP3 Gene

HapMap Linkage Disequilibrium report
SCAMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP3 Gene

Disorders for SCAMP3 Gene

Relevant External Links for SCAMP3

Genetic Association Database (GAD)
SCAMP3
genes like me logo Genes that share disorders with SCAMP3: view

No data available for UniProtKB/Swiss-Prot for SCAMP3 Gene

Publications for SCAMP3 Gene

  1. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. (PMID: 9331372) Winfield S.L. … Sidransky E. (Genome Res. 1997) 2 3 4
  2. Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. (PMID: 9378760) Singleton D.R. … Castle J.D. (J. Cell Sci. 1997) 3 4
  3. Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor. (PMID: 9658162) Wu T.T. … Castle J.D. (Mol. Biol. Cell 1998) 2 3
  4. SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling. (PMID: 19158374) Aoh Q.L. … Castle J.D. (Mol. Biol. Cell 2009) 3 4
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4

Products for SCAMP3 Gene

Sources for SCAMP3 Gene

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