SCAMP3 Gene
protein-coding GIFtS: 54
GCID: GC01M155225
|
|
secretory carrier membrane protein 3
(Previous symbol: C1orf3)
| |
Aliases
for SCAMP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Secretory Carrier Membrane Protein 31 2 3 | | C1orf31 2 3 | | PROPIN13 5 | | Propin 12 | | Secretory Carrier-Associated Membrane Protein 32 |
Export aliases for SCAMP3 gene to outside databasesPrevious GC identifers: GC01M153083 GC01M150966 GC01M152003 GC01M152442 GC01M152038 GC01M153494 GC01M126588 |
Summaries
for SCAMP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SCAMP3:
This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. Theencoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is alsoinvolved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have beenfound for this gene.(provided by RefSeq, May 2011)
UniProtKB/Swiss-Prot: SCAM3_HUMAN, O14828Function: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface
Gene Wiki entry for SCAMP3
|
Genomic Views
for SCAMP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SCAMP3 gene promoter:
AhR MAZR Bach2 Tal-1beta Arnt PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SCAMP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAMP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q21SCAMP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M155225: view genomic region
(about GC identifiers)
Start:
|
155,225,770 bp from pter |
End:
|
155,232,221 bp from pter |
Size:
|
6,452 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr1-,PATCHES 155,241,160-155,247,585 |
|
Proteins
for SCAMP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCAM3_HUMAN, O14828 (See
protein sequence)Recommended Name: Secretory carrier-associated membrane protein 3 Size: 347 amino acids; 38287 Da
Subunit: Interacts with NEDD4 and NEDD4L
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A9Z1W6 B1AVS6 O15128 Q96FR8 Q9BPY0Alternative splicing: 2 isoforms: O14828-1 O14828-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SCAMP3: NX_O14828
Post-translational modifications:
Monoubiquitinated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14828
SCAMP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_005689.2 NP_443069.1
ENSEMBL proteins: ENSP00000307275 ENSP00000347540
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000139 | Golgi membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SCAMP3 for ontologies About GeneDecksing
SCAMP3 Antibody Products:
Assay Products for SCAMP3: |
Protein
Domains /
Families
for SCAMP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SCAMP3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O14828ProtoNet protein and cluster: O14828 1 Blocks protein family: IPB007273 SCAMP
UniProtKB/Swiss-Prot: SCAM3_HUMAN, O14828Similarity: Belongs to the SCAMP family |
Function
for SCAMP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SCAM3_HUMAN, O14828Function: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface Genatlas biochemistry entry for SCAMP3:secretory carrier membrane protein 3,widely expressed,as component of post-Golgi membranes,homolog of rat secretorycarrier membrane protein 37 (SCAMP37),involved in cell surface recycling
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAMP3 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAMP3 |
1 GenomeRNAi human phenotype for SCAMP3:
|
Pathways & Interactions
for SCAMP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SCAMP3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/15 Interacting proteins for SCAMP3 (O148283 ENSP000003072754) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SCAMP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SCAMP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SCAMP3
Search CenterWatch for drugs/clinical trials and news about SCAMP3 / SCAM3
|
Transcripts
for SCAMP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SCAMP3 gene (2 alternative transcripts): NM_005698.3 NM_052837.2 Unigene Cluster for SCAMP3: Secretory carrier membrane protein 3 Hs.200600 [show with all ESTs]Unigene Representative Sequence: NM_0056989 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000478737 ENST00000302631 ENST00000355379(uc001fjs.3 uc001fjt.3)
ENST00000472397 ENST00000490999 ENST00000465312 ENST00000462151 ENST00000497470
ENST00000480219
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAMP3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Synthesis Service for SCAMP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAMP3 |
Additional cDNA sequence: AF005039.1 BC000161.2 BC005135.2 BC010505.1 CR541757.1 22 DOTS entries: DT.100867018 DT.92450121 DT.117743 DT.95169011 DT.92450127 DT.92450145 DT.86855039 DT.97792831 DT.100858578 DT.95169008 DT.97860115 DT.100646697 DT.92450143 DT.95168996 DT.95168997 DT.95169009 DT.95169010 DT.100706438 DT.100772714 DT.100858571 DT.95354757 DT.97766499 24/442 AceView cDNA sequences (see all 442): CR595790 AI754725 BM810258 BQ231347 BQ024128 BM709911 BE906441 CR620488 BQ019290 CA975872 CR610056 BU630429 CR608453 AI928846 BG420042 CR616361 CR595229 CA488611 BU163964 CR623315 BI752796 BM825178 BF514941 BM720843
GeneLoc Exon Structure
5/19 Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP3 (see all 19) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | |
| ExUns: | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for SCAMP3
|
Expression
for SCAMP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SCAMP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGCTGAAC
About this image
See SCAMP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCAMP3
SOURCE GeneReport for Unigene cluster: Hs.200600
UniProtKB/Swiss-Prot: SCAM3_HUMAN, O14828Tissue specificity: Widely expressed, with highest expression in heart and skeletal muscle
SABiosciences Custom PCR Arrays for SCAMP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCAMP3
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAMP3 |
Orthologs
for SCAMP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SCAMP3 gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for SCAMP3 (if available)
TreeFam Gene Tree for SCAMP3 (if available) |
Paralogs
for SCAMP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SCAMP3 gene
- SCAMP22 SCAMP52 SCAMP42
4 SIMAP similar genes for SCAMP3 using alignment to 2 protein entries: SCAM3_HUMAN (see all proteins):SCAMP5 SCAMP4 SCAMP1 SCAMP2
SCAMP3 for paralogs About GeneDecksing
|
Genomic Variants
for SCAMP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SCAMP3 (155225770 - 155232221 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SCAMP3
4 CNVs: 3315 65020 4257 6789 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCAMP3 |
|
Disorders
/ Diseases
for SCAMP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SCAMP3 for disorders About GeneDecksing
OMIM gene information: 606913
OMIM disorders: --
3  diseases for SCAMP3: About MalaCardsnephronopthisis gaucher's disease crohn's disease
Export disorders for SCAMP3 gene to outside databases
|
Publications
for SCAMP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SCAMP3 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with SCAMP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. (PubMed id 9331372)1, 2, 3 Winfield S.L.... Sidransky E. (1997)
- SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling. (PubMed id 19158374)1, 2 Aoh Q.L....Castle J.D. (2009)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor. (PubMed id 9658162)1, 3 Wu T.T. and Castle J.D. (1998)
- Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. (PubMed id 9378760)1, 2 Singleton D.R.... Castle J.D. (1997)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Regulation of the MVB pathway by SCAMP3. (PubMed id 21951651)1 Falguieres T....Gruenberg J. (2012)
|
External Searches for SCAMP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SCAMP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SCAMP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SCAMP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SCAMP3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SCAMP3 gene:
Search GeneIP for patents involving SCAMP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SCAMP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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