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Aliases for SCAMP2 Gene

Aliases for SCAMP2 Gene

  • Secretory Carrier Membrane Protein 2 2 3 4

External Ids for SCAMP2 Gene

Previous GeneCards Identifiers for SCAMP2 Gene

  • GC15P070892
  • GC15P068180
  • GC15M072711
  • GC15M072853
  • GC15M072924
  • GC15M075136
  • GC15M051934

Summaries for SCAMP2 Gene

Entrez Gene Summary for SCAMP2 Gene

  • This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCAMP2 Gene

SCAMP2 (Secretory Carrier Membrane Protein 2) is a Protein Coding gene. Diseases associated with SCAMP2 include bartter disease. Among its related pathways are Arf6 trafficking events and Monoamine Transport. An important paralog of this gene is SCAMP3.

UniProtKB/Swiss-Prot for SCAMP2 Gene

  • Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface

Gene Wiki entry for SCAMP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP2 Gene

Genomics for SCAMP2 Gene

Regulatory Elements for SCAMP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCAMP2 Gene

74,843,730 bp from pter
74,873,365 bp from pter
29,636 bases
Minus strand

Genomic View for SCAMP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCAMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP2 Gene

Proteins for SCAMP2 Gene

  • Protein details for SCAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secretory carrier-associated membrane protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RDF0
    • Q9BQE8

    Protein attributes for SCAMP2 Gene

    329 amino acids
    Molecular mass:
    36649 Da
    Quaternary structure:
    • Interacts with SLC6A4 and SLC9A7.

neXtProt entry for SCAMP2 Gene

Proteomics data for SCAMP2 Gene at MOPED

Post-translational modifications for SCAMP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCAMP2 Gene

Antibody Products

No data available for DME Specific Peptides for SCAMP2 Gene

Domains for SCAMP2 Gene

Gene Families for SCAMP2 Gene

  • SCAMP :Secretory carrier membrane proteins

Protein Domains for SCAMP2 Gene


Suggested Antigen Peptide Sequences for SCAMP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • O15127
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP2: view

Function for SCAMP2 Gene

Molecular function for SCAMP2 Gene

GENATLAS Biochemistry:
secretory carrier membrane protein 2,widely distributed as component of post-Golgi membranes,involved in cell surface recycling
UniProtKB/Swiss-Prot Function:
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface

Gene Ontology (GO) - Molecular Function for SCAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15840657
genes like me logo Genes that share ontologies with SCAMP2: view

Phenotypes for SCAMP2 Gene

GenomeRNAi human phenotypes for SCAMP2:
genes like me logo Genes that share phenotypes with SCAMP2: view

Animal Model Products

miRNA for SCAMP2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCAMP2 Gene

Localization for SCAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP2 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SCAMP2 Gene COMPARTMENTS Subcellular localization image for SCAMP2 gene
Compartment Confidence
endosome 5
golgi apparatus 4
nucleus 4
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SCAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IDA 15840657
GO:0030133 transport vesicle IEA --
genes like me logo Genes that share ontologies with SCAMP2: view

Pathways for SCAMP2 Gene

genes like me logo Genes that share pathways with SCAMP2: view

Pathways by source for SCAMP2 Gene

Interacting Proteins for SCAMP2 Gene

Gene Ontology (GO) - Biological Process for SCAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport TAS 9378760
GO:0015031 protein transport IDA 15840657
genes like me logo Genes that share ontologies with SCAMP2: view

Transcripts for SCAMP2 Gene

Unigene Clusters for SCAMP2 Gene

Secretory carrier membrane protein 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCAMP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for SCAMP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAMP2 Gene

mRNA expression in normal human tissues for SCAMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SCAMP2 Gene

This gene is overexpressed in Nasal epithelium (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAMP2 Gene

SOURCE GeneReport for Unigene cluster for SCAMP2 Gene Hs.458917

mRNA Expression by UniProt/SwissProt for SCAMP2 Gene

Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with SCAMP2: view

Expression partners for SCAMP2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SCAMP2 Gene

Orthologs for SCAMP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCAMP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCAMP2 35
  • 90.96 (n)
  • 92.68 (a)
  • 92 (a)
(Canis familiaris)
Mammalia SCAMP2 35
  • 89.97 (n)
  • 90.58 (a)
  • 86 (a)
(Mus musculus)
Mammalia Scamp2 35
  • 87.23 (n)
  • 88.75 (a)
Scamp2 16
Scamp2 36
  • 89 (a)
(Pan troglodytes)
Mammalia SCAMP2 35
  • 99.7 (n)
  • 99.7 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Scamp2 35
  • 87.03 (n)
  • 88.15 (a)
(Monodelphis domestica)
Mammalia SCAMP2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia SCAMP2 36
  • 58 (a)
(Gallus gallus)
Aves SCAMP2 35
  • 77.49 (n)
  • 80.19 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia SCAMP2 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp2 35
  • 67.6 (n)
  • 73.52 (a)
Str.4084 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24270 35
(Danio rerio)
Actinopterygii ceacam1 35
scamp2l 35
  • 68.23 (n)
  • 66.25 (a)
scamp2 36
  • 64 (a)
scamp2l 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Scamp 37
  • 39 (a)
Scamp 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea scm-1 36
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SC3 35
  • 43.69 (n)
  • 30.68 (a)
(Oryza sativa)
Liliopsida Os01g0780500 35
  • 45.51 (n)
  • 31.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8273 36
  • 44 (a)
Species with no ortholog for SCAMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP2 Gene

Gene Tree for SCAMP2 (if available)
Gene Tree for SCAMP2 (if available)

Paralogs for SCAMP2 Gene

Paralogs for SCAMP2 Gene

Selected SIMAP similar genes for SCAMP2 Gene using alignment to 8 proteins: Pseudogenes for SCAMP2 Gene

genes like me logo Genes that share paralogs with SCAMP2: view

Variants for SCAMP2 Gene

Sequence variations from dbSNP and Humsavar for SCAMP2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs729263 -- 74,870,410(+) TTCTG(A/G)TTCTG intron-variant
rs936230 -- 74,852,757(-) AGCCA(A/G)TTGCA intron-variant
rs1869959 -- 74,854,991(-) ACCCC(G/T)CAAAA intron-variant
rs2305667 -- 74,852,202(-) TACCT(C/T)CCCTG intron-variant
rs2305668 -- 74,850,420(-) GTCTT(A/C)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP2 Gene

Variant ID Type Subtype PubMed ID
nsv904380 CNV Loss 21882294
nsv833055 CNV Loss 17160897
nsv904381 CNV Loss 21882294
nsv904382 CNV Loss 21882294
nsv827386 CNV Gain 20364138
nsv827388 CNV Gain 20364138

Relevant External Links for SCAMP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP2 Gene

Disorders for SCAMP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SCAMP2 Gene in MalaCards »

(1) Diseases for SCAMP2 Gene including...

(1) University of Copenhagen DISEASES for SCAMP2 Gene

Relevant External Links for SCAMP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SCAMP2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SCAMP2 Gene

Publications for SCAMP2 Gene

  1. Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2. (PMID: 16870614) Mueller H.K. … Haase J. (J. Biol. Chem. 2006) 3 4 23
  2. Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. (PMID: 9378760) Singleton D.R. … Castle J.D. (J. Cell Sci. 1997) 2 3 4
  3. Secretory carrier membrane protein SCAMP2 and phosphatidylinositol 4,5-bisphosphate interactions in the regulation of dense core vesicle exocytosis. (PMID: 17713930) Liao H. … Castle D. (Biochemistry 2007) 3 23
  4. Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5. (PMID: 19276089) Diering G.H. … Numata M. (J. Biol. Chem. 2009) 3 23
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 48

Products for SCAMP2 Gene

Sources for SCAMP2 Gene

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