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Aliases for SCAMP2 Gene

Aliases for SCAMP2 Gene

  • Secretory Carrier Membrane Protein 2 2 3 4 5

External Ids for SCAMP2 Gene

Previous GeneCards Identifiers for SCAMP2 Gene

  • GC15P070892
  • GC15P068180
  • GC15M072711
  • GC15M072853
  • GC15M072924
  • GC15M075136
  • GC15M051934

Summaries for SCAMP2 Gene

Entrez Gene Summary for SCAMP2 Gene

  • This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for SCAMP2 Gene

SCAMP2 (Secretory Carrier Membrane Protein 2) is a Protein Coding gene. Among its related pathways are Monoamine Transport and Arf6 trafficking events. An important paralog of this gene is SCAMP1.

UniProtKB/Swiss-Prot for SCAMP2 Gene

  • Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Gene Wiki entry for SCAMP2 Gene

Additional gene information for SCAMP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP2 Gene

Genomics for SCAMP2 Gene

GeneHancer (GH) Regulatory Elements for SCAMP2 Gene

Promoters and enhancers for SCAMP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I074865 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.1 +3.5 3547 8.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 SCAMP2 RPP25 EDC3 SIN3A ENSG00000260274 SNUPN UBL7-AS1 DNM1P34 MPI SCAMP5
GH15I074841 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15.6 +29.5 29506 5 HDGF PKNOX1 SMAD1 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B ULK3 SIN3A RPP25 EDC3 ENSG00000260274 ENSG00000203392 MPI SCAMP2 MAN2C1 SNX33
GH15I074953 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.8 -83.3 -83291 5.4 PKNOX1 CLOCK SMAD1 ARNT SIN3A DMAP1 YY1 ZNF766 E2F8 ZNF207 RPP25 SCAMP5 MAN2C1 ENSG00000260274 FBXO22 ENSG00000203392 SIN3A FAM219B MPI ULK3
GH15I074316 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 10.5 +554.8 554821 4.3 HDGF GLIS2 ZNF143 KLF7 RUNX3 YY2 NFYC REST ZSCAN16 GLIS1 CCDC33 ENSG00000277749 PML ISLR LOC101929333 CLK3 UBL7-AS1 STRA6 SCAMP2 CSK
GH15I075110 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11 -239.2 -239216 3.7 PKNOX1 SMAD1 ARNT YBX1 IRF4 TCF12 GATA2 ATF7 RUNX3 JUNB GC15P075113 LOC100128721 C15orf39 RPP25 SCAMP5 SCAMP2 MAN2C1 SIN3A CSK CLK3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SCAMP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCAMP2 gene promoter:

Genomic Locations for SCAMP2 Gene

Genomic Locations for SCAMP2 Gene
chr15:74,843,730-74,873,365
(GRCh38/hg38)
Size:
29,636 bases
Orientation:
Minus strand
chr15:75,136,071-75,165,706
(GRCh37/hg19)

Genomic View for SCAMP2 Gene

Genes around SCAMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP2 Gene

Proteins for SCAMP2 Gene

  • Protein details for SCAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15127-SCAM2_HUMAN
    Recommended name:
    Secretory carrier-associated membrane protein 2
    Protein Accession:
    O15127
    Secondary Accessions:
    • B2RDF0
    • Q9BQE8

    Protein attributes for SCAMP2 Gene

    Size:
    329 amino acids
    Molecular mass:
    36649 Da
    Quaternary structure:
    • Interacts with SLC6A4 and SLC9A7.

neXtProt entry for SCAMP2 Gene

Post-translational modifications for SCAMP2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SCAMP2 Gene

Domains & Families for SCAMP2 Gene

Gene Families for SCAMP2 Gene

Protein Domains for SCAMP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAMP2 Gene

Graphical View of Domain Structure for InterPro Entry

O15127

UniProtKB/Swiss-Prot:

SCAM2_HUMAN :
  • Belongs to the SCAMP family.
Family:
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP2: view

Function for SCAMP2 Gene

Molecular function for SCAMP2 Gene

GENATLAS Biochemistry:
secretory carrier membrane protein 2,widely distributed as component of post-Golgi membranes,involved in cell surface recycling
UniProtKB/Swiss-Prot Function:
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Phenotypes From GWAS Catalog for SCAMP2 Gene

Gene Ontology (GO) - Molecular Function for SCAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15840657
genes like me logo Genes that share ontologies with SCAMP2: view
genes like me logo Genes that share phenotypes with SCAMP2: view

Animal Model Products

CRISPR Products

miRNA for SCAMP2 Gene

miRTarBase miRNAs that target SCAMP2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAMP2 Gene

Localization for SCAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP2 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAMP2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endosome 5
plasma membrane 4
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA,IEA 15840657
GO:0030133 transport vesicle IEA --
genes like me logo Genes that share ontologies with SCAMP2: view

Pathways & Interactions for SCAMP2 Gene

genes like me logo Genes that share pathways with SCAMP2: view

Pathways by source for SCAMP2 Gene

Gene Ontology (GO) - Biological Process for SCAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006892 post-Golgi vesicle-mediated transport TAS 9378760
GO:0015031 protein transport IEA,IDA 15840657
genes like me logo Genes that share ontologies with SCAMP2: view

No data available for SIGNOR curated interactions for SCAMP2 Gene

Drugs & Compounds for SCAMP2 Gene

No Compound Related Data Available

Transcripts for SCAMP2 Gene

Unigene Clusters for SCAMP2 Gene

Secretory carrier membrane protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: -
SP6:

Relevant External Links for SCAMP2 Gene

GeneLoc Exon Structure for
SCAMP2
ECgene alternative splicing isoforms for
SCAMP2

Expression for SCAMP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCAMP2 Gene

Protein differential expression in normal tissues from HIPED for SCAMP2 Gene

This gene is overexpressed in Nasal epithelium (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCAMP2 Gene



Protein tissue co-expression partners for SCAMP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCAMP2 Gene:

SCAMP2

SOURCE GeneReport for Unigene cluster for SCAMP2 Gene:

Hs.458917

mRNA Expression by UniProt/SwissProt for SCAMP2 Gene:

O15127-SCAM2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SCAMP2 Gene

  • Skin(4.3)
  • Blood(4.2)
  • Liver(4.2)
  • Nervous system(3.8)
  • Intestine(2.8)
  • Lung(2.5)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with SCAMP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAMP2 Gene

Orthologs for SCAMP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCAMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAMP2 33 34
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia SCAMP2 33 34
  • 90.96 (n)
dog
(Canis familiaris)
Mammalia SCAMP2 33 34
  • 89.97 (n)
mouse
(Mus musculus)
Mammalia Scamp2 33 16 34
  • 87.23 (n)
rat
(Rattus norvegicus)
Mammalia Scamp2 33
  • 87.03 (n)
oppossum
(Monodelphis domestica)
Mammalia SCAMP2 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCAMP2 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCAMP2 33 34
  • 77.49 (n)
lizard
(Anolis carolinensis)
Reptilia SCAMP2 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp2 33
  • 67.6 (n)
Str.4084 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24270 33
zebrafish
(Danio rerio)
Actinopterygii scamp2l 33 34
  • 68.23 (n)
scamp2 34
  • 64 (a)
OneToMany
ceacam1 33
fruit fly
(Drosophila melanogaster)
Insecta Scamp 35 34
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea scm-1 34
  • 34 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SC3 33
  • 43.69 (n)
rice
(Oryza sativa)
Liliopsida Os01g0780500 33
  • 45.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8273 34
  • 44 (a)
OneToMany
Species where no ortholog for SCAMP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP2 Gene

ENSEMBL:
Gene Tree for SCAMP2 (if available)
TreeFam:
Gene Tree for SCAMP2 (if available)

Paralogs for SCAMP2 Gene

Paralogs for SCAMP2 Gene

(4) SIMAP similar genes for SCAMP2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SCAMP2: view

Variants for SCAMP2 Gene

Sequence variations from dbSNP and Humsavar for SCAMP2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000142415 -- 74,873,041(-) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000261123 -- 74,859,221(-) G/ intron_variant
rs1000350021 -- 74,873,075(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000392905 -- 74,866,071(-) A/G intron_variant
rs1000423999 -- 74,865,583(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP2 Gene

Variant ID Type Subtype PubMed ID
esv3636911 CNV loss 21293372
nsv1121512 CNV deletion 24896259
nsv569992 CNV loss 21841781
nsv827386 CNV gain 20364138
nsv827388 CNV gain 20364138
nsv833055 CNV loss 17160897
nsv958035 CNV deletion 24416366

Variation tolerance for SCAMP2 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCAMP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCAMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP2 Gene

Disorders for SCAMP2 Gene

Additional Disease Information for SCAMP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SCAMP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAMP2 Gene

Publications for SCAMP2 Gene

  1. Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2. (PMID: 16870614) Müller HK … Haase J (The Journal of biological chemistry 2006) 3 4 22 58
  2. Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. (PMID: 9378760) Singleton DR … Castle JD (Journal of cell science 1997) 2 3 4 58
  3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
  4. Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5. (PMID: 19276089) Diering GH … Numata M (The Journal of biological chemistry 2009) 3 22 58
  5. Secretory carrier membrane protein SCAMP2 and phosphatidylinositol 4,5-bisphosphate interactions in the regulation of dense core vesicle exocytosis. (PMID: 17713930) Liao H … Castle D (Biochemistry 2007) 3 22 58

Products for SCAMP2 Gene

Sources for SCAMP2 Gene

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