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Aliases for SCAMP1 Gene

Aliases for SCAMP1 Gene

  • Secretory Carrier Membrane Protein 1 2 3 4 5
  • SCAMP 3 4
  • Secretory Carrier-Associated Membrane Protein 1 3
  • SCAMP37 3

External Ids for SCAMP1 Gene

Previous GeneCards Identifiers for SCAMP1 Gene

  • GC05P076461
  • GC05P077893
  • GC05P077695
  • GC05P077740
  • GC05P077692
  • GC05P072862
  • GC05P077656

Summaries for SCAMP1 Gene

Entrez Gene Summary for SCAMP1 Gene

  • This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that these protein family members may function at the same site during vesicular transport rather than in separate pathways. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for SCAMP1 Gene

SCAMP1 (Secretory Carrier Membrane Protein 1) is a Protein Coding gene. Among its related pathways are Innate Immune System. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is SCAMP3.

UniProtKB/Swiss-Prot for SCAMP1 Gene

  • Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Gene Wiki entry for SCAMP1 Gene

Additional gene information for SCAMP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP1 Gene

Genomics for SCAMP1 Gene

Regulatory Elements for SCAMP1 Gene

Enhancers for SCAMP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H077645 2.3 VISTA 17 -715.2 -715212 0.6 HDGF ARNT YBX1 GLI4 ZNF2 ZNF416 ZNF143 KLF7 ZNF548 ZNF202 RPL7P23 SCAMP1 WDR41 AP3B1 AGGF1 OTP GC05M077675
GH05H078482 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8 +123.9 123900 2.8 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 ZNF143 SCAMP1-AS1 SCAMP1 AP3B1 PIR51536
GH05H078503 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.2 +147.5 147525 8.5 HDGF FEZF1 ZNF2 YY1 FOS REST ZNF592 ZNF610 SMARCA4 GLIS1 LHFPL2 SCAMP1-AS1 SCAMP1 ARSB AP3B1 PIR51536
GH05H078543 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.8 +186.1 186145 6.4 FOXA2 MLX YY1 TCF12 FOS ATF7 RUNX3 MXD4 JUNB PPARG LHFPL2 SCAMP1 PIR51536 GC05M078588
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCAMP1 on UCSC Golden Path with GeneCards custom track

Promoters for SCAMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000182930 297 2401 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Locations for SCAMP1 Gene

Genomic Locations for SCAMP1 Gene
120,237 bases
Plus strand

Genomic View for SCAMP1 Gene

Genes around SCAMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP1 Gene

Proteins for SCAMP1 Gene

  • Protein details for SCAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secretory carrier-associated membrane protein 1
    Protein Accession:
    Secondary Accessions:
    • O43587
    • Q6FG23
    • Q96BX1
    • Q96QK5

    Protein attributes for SCAMP1 Gene

    338 amino acids
    Molecular mass:
    37920 Da
    Quaternary structure:
    • Interacts with SYNRG and ITSN1 (By similarity). Interacts with SLC9A7.

    Alternative splice isoforms for SCAMP1 Gene


neXtProt entry for SCAMP1 Gene

Post-translational modifications for SCAMP1 Gene

  • Ubiquitination at Lys89, isoforms=298, Lys311, and Lys334
  • Modification sites at PhosphoSitePlus

Other Protein References for SCAMP1 Gene

No data available for DME Specific Peptides for SCAMP1 Gene

Domains & Families for SCAMP1 Gene

Gene Families for SCAMP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SCAMP1 Gene


Suggested Antigen Peptide Sequences for SCAMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SCAMP family.
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP1: view

Function for SCAMP1 Gene

Molecular function for SCAMP1 Gene

GENATLAS Biochemistry:
secretory carrier membrane protein 1,widely distributed as component of post-Golgi membranes,involved in cell surface recycling
UniProtKB/Swiss-Prot Function:
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Phenotypes From GWAS Catalog for SCAMP1 Gene

Gene Ontology (GO) - Molecular Function for SCAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15840657
genes like me logo Genes that share ontologies with SCAMP1: view
genes like me logo Genes that share phenotypes with SCAMP1: view

Animal Models for SCAMP1 Gene

MGI Knock Outs for SCAMP1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCAMP1 Gene

Localization for SCAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP1 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IDA 15840657
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SCAMP1: view

No data available for Subcellular locations from COMPARTMENTS for SCAMP1 Gene

Pathways & Interactions for SCAMP1 Gene

genes like me logo Genes that share pathways with SCAMP1: view

Pathways by source for SCAMP1 Gene

3 Reactome pathways for SCAMP1 Gene

Interacting Proteins for SCAMP1 Gene

Gene Ontology (GO) - Biological Process for SCAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 exocytosis IEA --
GO:0006892 post-Golgi vesicle-mediated transport TAS 9378760
GO:0015031 protein transport IEA,IDA 15840657
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with SCAMP1: view

No data available for SIGNOR curated interactions for SCAMP1 Gene

Drugs & Compounds for SCAMP1 Gene

No Compound Related Data Available

Transcripts for SCAMP1 Gene

Unigene Clusters for SCAMP1 Gene

Secretory carrier membrane protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - - -
SP4: - -

Relevant External Links for SCAMP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAMP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCAMP1 Gene

This gene is overexpressed in Fetal Brain (13.0) and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCAMP1 Gene

Protein tissue co-expression partners for SCAMP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCAMP1 Gene:


SOURCE GeneReport for Unigene cluster for SCAMP1 Gene:


mRNA Expression by UniProt/SwissProt for SCAMP1 Gene:

Tissue specificity: Widely expressed, with highest expression in brain.
genes like me logo Genes that share expression patterns with SCAMP1: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAMP1 Gene

Orthologs for SCAMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCAMP1 33
  • 99.7 (n)
(Canis familiaris)
Mammalia SCAMP1 33 34
  • 95.07 (n)
(Bos Taurus)
Mammalia SCAMP1 33 34
  • 92.44 (n)
(Ornithorhynchus anatinus)
Mammalia SCAMP1 34
  • 91 (a)
(Monodelphis domestica)
Mammalia SCAMP1 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Scamp1 33
  • 87.18 (n)
(Mus musculus)
Mammalia Scamp1 33 16 34
  • 86.49 (n)
(Gallus gallus)
Aves SCAMP1 33 34
  • 85.5 (n)
(Anolis carolinensis)
Reptilia SCAMP1 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp1 33
  • 77.15 (n)
(Danio rerio)
Actinopterygii scamp1 33 34
  • 70.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta Scamp 35 33 34
  • 51.27 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002922 33
  • 49.67 (n)
(Caenorhabditis elegans)
Secernentea scm-1 33 34
  • 50.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8273 34
  • 53 (a)
Species where no ortholog for SCAMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP1 Gene

Gene Tree for SCAMP1 (if available)
Gene Tree for SCAMP1 (if available)

Paralogs for SCAMP1 Gene

Paralogs for SCAMP1 Gene

(4) SIMAP similar genes for SCAMP1 Gene using alignment to 2 proteins: Pseudogenes for SCAMP1 Gene

genes like me logo Genes that share paralogs with SCAMP1: view

Variants for SCAMP1 Gene

Sequence variations from dbSNP and Humsavar for SCAMP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000034845 -- 78,408,667(+) ATGAT(C/G)TTGGC intron-variant
rs1000062987 -- 78,438,087(+) CATCT(A/G)TTTGA intron-variant
rs1000076441 -- 78,471,750(+) GTGAC(A/G)CTTCG intron-variant
rs1000083589 -- 78,359,737(+) GTGTT(C/G)GAAAA nc-transcript-variant, upstream-variant-2KB
rs1000098899 -- 78,388,358(+) GATAT(C/T)GGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP1 Gene

Variant ID Type Subtype PubMed ID
nsv955832 CNV deletion 24416366
nsv950096 CNV duplication 24416366
nsv328878 CNV deletion 16902084
nsv1147240 CNV deletion 26484159
nsv1142632 CNV deletion 24896259
nsv1140551 CNV deletion 24896259
nsv1123963 CNV deletion 24896259
nsv1021871 CNV gain 25217958
esv3605509 CNV loss 21293372
esv3566142 CNV deletion 23714750
esv2730336 CNV deletion 23290073
esv2730335 CNV deletion 23290073
esv2730334 CNV deletion 23290073
esv2026918 CNV deletion 18987734
esv1526123 CNV insertion 17803354
esv1508933 CNV deletion 17803354

Variation tolerance for SCAMP1 Gene

Gene Damage Index Score: 2.63; 45.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCAMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP1 Gene

Disorders for SCAMP1 Gene

Relevant External Links for SCAMP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCAMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAMP1 Gene

Publications for SCAMP1 Gene

  1. Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. (PMID: 9378760) Singleton DR … Castle JD (Journal of cell science 1997) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin SG … Alzheimer's Disease Neuroimaging Initiative (PloS one 2009) 3 45 60
  4. Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. (PMID: 15840657) Lin PJ … Numata M (Journal of cell science 2005) 3 4 60
  5. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman RT … Brenner SE (Genome biology 2004) 3 4 60

Products for SCAMP1 Gene

Sources for SCAMP1 Gene

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