Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SCAMP1 Gene

Aliases for SCAMP1 Gene

  • Secretory Carrier Membrane Protein 1 2 3 4 5
  • SCAMP 3 4
  • SCAMP37 3

External Ids for SCAMP1 Gene

Previous GeneCards Identifiers for SCAMP1 Gene

  • GC05P076461
  • GC05P077893
  • GC05P077695
  • GC05P077740
  • GC05P077692
  • GC05P072862
  • GC05P077656

Summaries for SCAMP1 Gene

Entrez Gene Summary for SCAMP1 Gene

  • This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that these protein family members may function at the same site during vesicular transport rather than in separate pathways. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for SCAMP1 Gene

SCAMP1 (Secretory Carrier Membrane Protein 1) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is SCAMP3.

UniProtKB/Swiss-Prot for SCAMP1 Gene

  • Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Gene Wiki entry for SCAMP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP1 Gene

Genomics for SCAMP1 Gene

Regulatory Elements for SCAMP1 Gene

Promoters for SCAMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCAMP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCAMP1 Gene

Chromosome:
5
Start:
78,360,503 bp from pter
End:
78,480,739 bp from pter
Size:
120,237 bases
Orientation:
Plus strand

Genomic View for SCAMP1 Gene

Genes around SCAMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP1 Gene

Proteins for SCAMP1 Gene

  • Protein details for SCAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15126-SCAM1_HUMAN
    Recommended name:
    Secretory carrier-associated membrane protein 1
    Protein Accession:
    O15126
    Secondary Accessions:
    • O43587
    • Q6FG23
    • Q96BX1
    • Q96QK5

    Protein attributes for SCAMP1 Gene

    Size:
    338 amino acids
    Molecular mass:
    37920 Da
    Quaternary structure:
    • Interacts with SYNRG and ITSN1 (By similarity). Interacts with SLC9A7.

    Alternative splice isoforms for SCAMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAMP1 Gene

Proteomics data for SCAMP1 Gene at MOPED

Post-translational modifications for SCAMP1 Gene

  • Ubiquitination at Lys 89, Lys 298, Lys 311, and Lys 334
  • Modification sites at PhosphoSitePlus

Other Protein References for SCAMP1 Gene

Antibody Products

No data available for DME Specific Peptides for SCAMP1 Gene

Domains & Families for SCAMP1 Gene

Gene Families for SCAMP1 Gene

Protein Domains for SCAMP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15126

UniProtKB/Swiss-Prot:

SCAM1_HUMAN :
  • Belongs to the SCAMP family.
Family:
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP1: view

Function for SCAMP1 Gene

Molecular function for SCAMP1 Gene

GENATLAS Biochemistry:
secretory carrier membrane protein 1,widely distributed as component of post-Golgi membranes,involved in cell surface recycling
UniProtKB/Swiss-Prot Function:
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
genes like me logo Genes that share phenotypes with SCAMP1: view

Animal Models for SCAMP1 Gene

MGI Knock Outs for SCAMP1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCAMP1 Gene

Localization for SCAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP1 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SCAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0016021 integral component of membrane IEA,IDA 15840657
GO:0030054 cell junction IDA --
GO:0030136 clathrin-coated vesicle ISS --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SCAMP1: view

No data available for Subcellular locations from COMPARTMENTS for SCAMP1 Gene

Pathways & Interactions for SCAMP1 Gene

SuperPathways for SCAMP1 Gene

No Data Available

Interacting Proteins for SCAMP1 Gene

Gene Ontology (GO) - Biological Process for SCAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport TAS 9378760
genes like me logo Genes that share ontologies with SCAMP1: view

No data available for Pathways by source and SIGNOR curated interactions for SCAMP1 Gene

Drugs & Compounds for SCAMP1 Gene

No Compound Related Data Available

Transcripts for SCAMP1 Gene

Unigene Clusters for SCAMP1 Gene

Secretory carrier membrane protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for SCAMP1 Gene

GeneLoc Exon Structure for
SCAMP1
ECgene alternative splicing isoforms for
SCAMP1

Expression for SCAMP1 Gene

mRNA expression in normal human tissues for SCAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCAMP1 Gene

This gene is overexpressed in Fetal Brain (13.0) and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SCAMP1 Gene



SOURCE GeneReport for Unigene cluster for SCAMP1 Gene Hs.482587

mRNA Expression by UniProt/SwissProt for SCAMP1 Gene

O15126-SCAM1_HUMAN
Tissue specificity: Widely expressed, with highest expression in brain.
genes like me logo Genes that share expression patterns with SCAMP1: view

Protein tissue co-expression partners for SCAMP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SCAMP1 Gene

Orthologs for SCAMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAMP1 35
  • 99.7 (n)
  • 99.7 (a)
cow
(Bos Taurus)
Mammalia SCAMP1 35
  • 92.44 (n)
  • 97.31 (a)
SCAMP1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCAMP1 36
  • 96 (a)
OneToOne
SCAMP1 35
  • 95.07 (n)
  • 97.04 (a)
mouse
(Mus musculus)
Mammalia Scamp1 36
  • 98 (a)
OneToOne
Scamp1 16
Scamp1 35
  • 86.49 (n)
  • 98.22 (a)
oppossum
(Monodelphis domestica)
Mammalia SCAMP1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCAMP1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scamp1 35
  • 87.18 (n)
  • 98.52 (a)
chicken
(Gallus gallus)
Aves SCAMP1 35
  • 85.5 (n)
  • 93.79 (a)
SCAMP1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAMP1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp1 35
  • 77.15 (n)
  • 88.92 (a)
zebrafish
(Danio rerio)
Actinopterygii scamp1 36
  • 79 (a)
OneToOne
scamp1 35
  • 70.61 (n)
  • 80.19 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002922 35
  • 49.67 (n)
  • 44.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Scamp 36
  • 43 (a)
OneToMany
Scamp 37
  • 44 (a)
Scamp 35
  • 51.27 (n)
  • 47.85 (a)
worm
(Caenorhabditis elegans)
Secernentea scm-1 35
  • 50.23 (n)
  • 41.44 (a)
scm-1 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8273 36
  • 53 (a)
OneToMany
Species with no ortholog for SCAMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP1 Gene

ENSEMBL:
Gene Tree for SCAMP1 (if available)
TreeFam:
Gene Tree for SCAMP1 (if available)

Paralogs for SCAMP1 Gene

Paralogs for SCAMP1 Gene

(4) SIMAP similar genes for SCAMP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCAMP1: view

Variants for SCAMP1 Gene

Sequence variations from dbSNP and Humsavar for SCAMP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs12994 -- 78,477,820(-) TGATC(A/G)TACTA nc-transcript-variant, utr-variant-3-prime
rs1060310 -- 78,416,579(+) CGCCA(A/G)GAAGA nc-transcript-variant, reference, synonymous-codon
rs1060311 -- 78,418,839(+) CAGGA(A/T)TTTTC nc-transcript-variant, reference, missense
rs891150 -- 78,465,971(-) ggtat(C/T)ttgta intron-variant
rs891151 -- 78,423,696(+) TTTTG(A/G)CAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP1 Gene

Variant ID Type Subtype PubMed ID
nsv328878 CNV Loss 16902084
esv1508933 CNV Deletion 17803354
esv2730334 CNV Deletion 23290073
esv2026918 CNV Deletion 18987734
esv2730335 CNV Deletion 23290073
esv2730336 CNV Deletion 23290073
esv1526123 CNV Insertion 17803354

Variation tolerance for SCAMP1 Gene

Gene Damage Index Score: 2.63; 45.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCAMP1 Gene

HapMap Linkage Disequilibrium report
SCAMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP1 Gene

Disorders for SCAMP1 Gene

Relevant External Links for SCAMP1

Genetic Association Database (GAD)
SCAMP1
Human Genome Epidemiology (HuGE) Navigator
SCAMP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCAMP1

No disorders were found for SCAMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAMP1 Gene

Publications for SCAMP1 Gene

  1. Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. (PMID: 9378760) Singleton D.R. … Castle J.D. (J. Cell Sci. 1997) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells. (PMID: 23653380) Yang S. … Rhee J.C. (Tumour Biol. 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for SCAMP1 Gene

Sources for SCAMP1 Gene

Back to Top

Content