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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SCAI Gene

protein-coding GIFtS: 47
GCID: GC09M127704

suppressor of cancer cell invasion

(Previous name: chromosome 9 open reading frame 126 )
(Previous symbol: C9orf126)

Explore 1 disease affiliated with
SCAI via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Suppressor Of Cancer Cell Invasion¹ ²		FLJ36664¹
C9orf126¹ ² ³		Chromosome 9 Open Reading Frame 126¹
NET40¹ ²		Protein SCAI²
Suppressor Of Cancer Cell Invasion Protein² ³

External Ids:	HGNC: 26709¹	Entrez Gene: 286205²	Ensembl: ENSG00000173611⁷	UniProtKB: Q8N9R8³

Export aliases for SCAI gene to outside databases

Previous GC identifers: GC09M126755 GC09M097317

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SCAI:

This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene

family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants

have been described. (provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: SCAI_HUMAN, Q8N9R8

Function: Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the

RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SCAI
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAI

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q34.11

SCAI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCAI gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M127704: view genomic region (about GC identifiers)

Start:	127,704,887 bp from pter	End:	127,905,838 bp from pter
Size:	200,952 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SCAI_HUMAN, Q8N9R8 (See protein sequence)

Recommended Name: Protein SCAI

Size: 606 amino acids; 70399 Da

Subunit: Interacts with DIAPH1 (By similarity). Forms a nuclear ternary complex with MKL1 and SRF

Subcellular location: Membrane; Single-pass membrane protein (Potential). Nucleus. Cytoplasm. Note=Nuclear localization

is required for inhibition of MKL1 (By similarity)

Secondary accessions: Q3SXZ1 Q3SXZ2 Q5T163 Q8N1I4

Alternative splicing: 2 isoforms: Q8N9R8-1 Q8N9R8-2

Explore the universe of human proteins at neXtProt for SCAI: NX_Q8N9R8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N9R8

SCAI Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001138349.1 NP_775961.2

ENSEMBL proteins:

ENSP00000336756 ENSP00000362650 ENSP00000419576 ENSP00000418148 ENSP00000419358

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0016021	integral to membrane	IEA	--

SCAI for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SCAI for domains About GeneDecksing

2 InterPro domains/families:

IPR016607 UCP013022

IPR022709 DUF3550

Graphical View of Domain Structure for InterPro Entry Q8N9R8

ProtoNet protein and cluster: Q8N9R8

UniProtKB/Swiss-Prot: SCAI_HUMAN, Q8N9R8

Similarity: Belongs to the SCAI family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SCAI_HUMAN, Q8N9R8

Function: Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the

RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003714	transcription corepressor activity	IMP	19350017
GO:0005515	protein binding	IPI	19350017

SCAI for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SCAI:

Decreased viability of wild-ty

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SCAI

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/7 Interacting proteins for SCAI (Q8N9R8³ ENSP00000362650⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TADA2B	Q86TJ2³	I2D: score=5
RAD54L	Q92698³	I2D: score=4
RPS8	P62241³	I2D: score=4
SRF	ENSP00000265354⁴	STRING: ENSP00000265354
ITGB1	ENSP00000364094⁴	STRING: ENSP00000364094

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0030336	negative regulation of cell migration	IMP	19350017
GO:0035024	negative regulation of Rho protein signal transduction	ISS	--

SCAI for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about SCAI

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for SCAI gene (2 alternative transcripts):

NM_001144877.2 NM_173690.4

Unigene Cluster for SCAI:

Suppressor of cancer cell invasion

Hs.59504 [show with all ESTs]

Unigene Representative Sequence: NM_173690

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000336505(uc004bpd.3 uc004bpe.3 uc010mwu.3) ENST00000373549

ENST00000477186 ENST00000467917 ENST00000494102 ENST00000487795 ENST00000468569

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		hsa-miR-579 hsa-miR-361-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-519a hsa-miR-3622b-3p hsa-miR-298 hsa-miR-3909

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Additional cDNA sequence:

AF086497.1 AK021820.1 AK093983.1 AK098024.1 AL050012.1 BC029431.1 BC037940.1 BC104030.2

BC104031.1

12 DOTS entries:

DT.100804252 DT.40116105 DT.305544 DT.86840618 DT.121162362 DT.91785959 DT.95368187 DT.40294444

DT.209436 DT.121193523 DT.40307222 DT.91851582

20 AceView cDNA sequences:

AX748393 AF086497 BX105452 AK093983 CA424863 AA829836 AW978891 BC029431

W93859 AW297952 AK098024 AI015678 NM_173690 AW298468 W93898 N78319

BI004178 BG497612 BG495801 AV754547

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SCAI expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTTTGTAC

About this image
See SCAI Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SCAI

SOURCE GeneReport for Unigene cluster: Hs.59504

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCAI gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Scai^{1 , 5}	suppressor of cancer cell invasion^{1, 5}	91.53(n)¹ 97.52(a)¹		2 (24.42 cM)⁵ 320271¹ NM_178778.3¹ NP_848893.2¹ 39066214⁵
chicken (Gallus gallus)	Aves	SCAI¹	suppressor of cancer cell invasion	84.58(n) 97.56(a)		427751 XM_425325.3 XP_425325.3
lizard (Anolis carolinensis)	Reptilia	SCAI⁶	--	91(a)	1 ↔ 1	GL344637.1(13049-24731)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8413²	Xenopus laevis transcribed sequence with weak similarity more	80.45(n)		AW158123.1
zebrafish (Danio rerio)	Actinopterygii	scai¹	suppressor of cancer cell invasion	71.74(n) 81.77(a)		556383 XM_679172.3 XP_684264.1
fruit fly (Drosophila melanogaster)	Insecta	CG13293¹	CG13293	55.23(n) 55.23(a)		38695 NM_139767.1 NP_648024.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G03570¹	hypothetical protein	46.05(n) 37.38(a)		821234 NM_111228.3 NP_566209.1
rice (Oryza sativa)	Liliopsida	-- --	AGAP005770-PA, putative, expressed	29(a) 28(a)	many → 1 many → 1	9(22933500-22938707) 9(17917677-17922875)

ENSEMBL Gene Tree for SCAI (if available)
TreeFam Gene Tree for SCAI (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191157376^1,2		--	127705432(+)	`TAGAAA/CACAAC`	2	--	ut3¹		0	--	--	--	--
rs181996735^1,2		--	127705717(+)	`TAGCTC/TCATTA`	2	--	ut3¹		0	--	--	--	--
rs186608016^1,2		--	127705776(+)	`ATATTA/GTGCTT`	2	--	ut3¹		0	--	--	--	--
rs11557468^1,2	F,	--	127705835(+)	`AAATTC/TTATAA`	2	--	ut3¹		1		NA	120
rs191921762^1,2		--	127705844(+)	`AACATA/TTCAGT`	2	--	ut3¹		0	--	--	--	--
rs182976057^1,2		--	127705973(+)	`TGTAGA/GCAATA`	2	--	ut3¹		0	--	--	--	--
rs188414860^1,2		--	127705980(+)	`AATAAA/GTTCAG`	2	--	ut3¹		0	--	--	--	--
rs16927779^1,2	C,F,H,	--	127706079(+)	`AAGGGA/GAACTC`	2	--	ut3¹		15		NA NS EA WA CSA	1454
rs143144433^1,2		--	127706127(+)	`GTGTCC/GTGAAA`	2	--	ut3¹		0	--	--	--	--
rs189647889^1,2		--	127706404(+)	`AGCAAA/GAAAGT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SCAI (127704887 - 127905838 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SCAI
1 CNV: 100781

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SCAI for disorders About GeneDecksing

1 disease for SCAI: About MalaCards

cerebrovascular accident

1 disease from the University of Copenhagen DISEASES database for SCAI:

Transient cerebral ischemia

Human Genome Epidemiology (HuGE) Navigator: SCAI (6 documents)

Export disorders for SCAI gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SCAI gene integrated from 9 sources:
(articles sorted by number of sources associating them with SCAI)

Utopia: connect your pdf to the dynamic
world of online information

SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. (PubMed id 19350017)^{1, 2} Brandt D.T.... Grosse R. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)¹ Nozawa R.S....Obuse C. (2010)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 286205	HGNC: 26709	AceView: C9orf126	Ensembl:ENSG00000173611	euGenes: HUgn286205
ECgene: SCAI	H-InvDB: SCAI

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SCAI	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SCAI gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SCAI gene:
Search GeneIP for patents involving SCAI

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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	OriGene Antibodies for SCAI		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SCAI		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SCAI
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	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SCAI		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SCAI
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SCAI		OriGene Custom Protein Services for SCAI
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SCAI
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SCAI
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAI
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SCAI
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCAI
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCAI

	GenScript Custom Purified and Recombinant Proteins Services for SCAI		GenScript cDNA clones with any tag delivered in your preferred vector for SCAI
	GenScript Custom Assay Services for SCAI		GenScript Custom Superior Antibodies Services for SCAI
	GenScript Custom overexpressing Cell Line Services for SCAI		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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ThermoFisher Antibody for SCAI

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAI

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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suppressor of cancer cell invasion

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SCAI Gene

suppressor of cancer cell invasion

Aliasesfor SCAI gene

Summariesfor SCAI gene

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Protein Domains /Familiesfor SCAI gene

Functionfor SCAI gene

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