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Aliases for SCAF8 Gene

Aliases for SCAF8 Gene

  • SR-Related CTD-Associated Factor 8 2 3
  • SR-Related And CTD-Associated Factor 8 3 4
  • CDC5L Complex-Associated Protein 7 3 4
  • RNA-Binding Motif Protein 16 3 4
  • RBM16 3 4
  • SR-Like CTD-Associated Factor 8 3
  • RNA Binding Motif Protein 16 2
  • Protein SCAF8 3
  • KIAA1116 4
  • CCAP7 4

External Ids for SCAF8 Gene

Previous Symbols for SCAF8 Gene

  • RBM16

Summaries for SCAF8 Gene

GeneCards Summary for SCAF8 Gene

SCAF8 (SR-Related CTD-Associated Factor 8) is a Protein Coding gene. GO annotations related to this gene include RNA binding and RNA polymerase core enzyme binding. An important paralog of this gene is SCAF4.

UniProtKB/Swiss-Prot for SCAF8 Gene

  • May play a role in mRNA processing.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAF8 Gene

Genomics for SCAF8 Gene

Genomic Location for SCAF8 Gene

Start:
154,733,325 bp from pter
End:
154,834,244 bp from pter
Size:
100,920 bases
Orientation:
Plus strand

Genomic View for SCAF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCAF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAF8 Gene

No data available for Regulatory Elements for SCAF8 Gene

Proteins for SCAF8 Gene

  • Protein details for SCAF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPN6-SCAF8_HUMAN
    Recommended name:
    Protein SCAF8
    Protein Accession:
    Q9UPN6
    Secondary Accessions:
    • B7Z888
    • Q5TBU6
    • Q6NSK3
    • Q9BQN8
    • Q9BX43

    Protein attributes for SCAF8 Gene

    Size:
    1271 amino acids
    Molecular mass:
    140519 Da
    Quaternary structure:
    • Interacts with POLR2A (via C-terminus). Has much higher affinity for phosphorylated POLR2A. Identified in a complex with CDC5L and other spliceosomal proteins. May associate with the spliceosome.
    SequenceCaution:
    • Sequence=BAA83068.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCAF8 Gene

    Alternative splice isoforms for SCAF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAF8 Gene

Proteomics data for SCAF8 Gene at MOPED

Post-translational modifications for SCAF8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys119

Other Protein References for SCAF8 Gene

No data available for DME Specific Peptides for SCAF8 Gene

Domains for SCAF8 Gene

Gene Families for SCAF8 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

SCAF8_HUMAN
Domain:
  • Contains 1 CID domain.:
    • Q9UPN6
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q9UPN6
genes like me logo Genes that share domains with SCAF8: view

Function for SCAF8 Gene

Molecular function for SCAF8 Gene

UniProtKB/Swiss-Prot Function: May play a role in mRNA processing.

Gene Ontology (GO) - Molecular Function for SCAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043175 RNA polymerase core enzyme binding IPI 18550522
genes like me logo Genes that share ontologies with SCAF8: view

Phenotypes for SCAF8 Gene

GenomeRNAi human phenotypes for SCAF8:
genes like me logo Genes that share phenotypes with SCAF8: view

miRNA for SCAF8 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCAF8 Gene

Localization for SCAF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAF8 Gene

Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of active transcription. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for SCAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IEA --
GO:0016363 nuclear matrix ISS --
genes like me logo Genes that share ontologies with SCAF8: view

Pathways for SCAF8 Gene

SuperPathways for SCAF8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SCAF8: view

No data available for Pathways by source for SCAF8 Gene

Transcripts for SCAF8 Gene

Unigene Clusters for SCAF8 Gene

SR-related CTD-associated factor 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCAF8 Gene

No ASD Table

Relevant External Links for SCAF8 Gene

GeneLoc Exon Structure for
SCAF8
ECgene alternative splicing isoforms for
SCAF8

Expression for SCAF8 Gene

mRNA expression in normal human tissues for SCAF8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCAF8 Gene

SOURCE GeneReport for Unigene cluster for SCAF8 Gene Hs.591329

genes like me logo Genes that share expressions with SCAF8: view

Orthologs for SCAF8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAF8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAF8 36
  • 99.75 (n)
  • 99.85 (a)
SCAF8 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCAF8 36
  • 91.9 (n)
  • 95.5 (a)
SCAF8 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1116 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scaf8 36
  • 88.56 (n)
  • 91.64 (a)
Scaf8 16
Scaf8 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCAF8 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCAF8 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scaf8 36
  • 88.22 (n)
  • 91.72 (a)
chicken
(Gallus gallus)
Aves SCAF8 36
  • 78.77 (n)
  • 80.94 (a)
SCAF8 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAF8 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scaf8 36
  • 70.76 (n)
  • 70.7 (a)
Str.3128 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6704 36
zebrafish
(Danio rerio)
Actinopterygii scaf4b 37
  • 38 (a)
ManyToMany
wu:fd99c08 36
  • 63.06 (n)
  • 64.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4266 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nrd-1 37
  • 23 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7297 36
Species with no ortholog for SCAF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAF8 Gene

ENSEMBL:
Gene Tree for SCAF8 (if available)
TreeFam:
Gene Tree for SCAF8 (if available)

Paralogs for SCAF8 Gene

Paralogs for SCAF8 Gene

Selected SIMAP similar genes for SCAF8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCAF8: view

Variants for SCAF8 Gene

Sequence variations from dbSNP and Humsavar for SCAF8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9375 -- 154,833,905(-) AGACC(A/G)TAGTG utr-variant-3-prime
rs911191 -- 154,831,177(+) GGTTG(C/G)CTCTC intron-variant
rs1047393 -- 154,833,861(+) GGAGC(A/C)CAATA utr-variant-3-prime
rs1137816 -- 154,812,374(-) aagtg(A/T)gcaac intron-variant
rs2351845 -- 154,819,157(-) CTGAT(A/G)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAF8 Gene

Variant ID Type Subtype PubMed ID
esv275420 CNV Gain+Loss 21479260
nsv886788 CNV Loss 21882294
esv23624 CNV Loss 19812545
esv2674803 CNV Deletion 23128226
esv32566 CNV Loss 17666407
nsv5551 CNV Loss 18451855
nsv823882 CNV Loss 20364138

Relevant External Links for SCAF8 Gene

HapMap Linkage Disequilibrium report
SCAF8

Disorders for SCAF8 Gene

No disorders were found for SCAF8 Gene.

No data available for UniProtKB/Swiss-Prot for SCAF8 Gene

Publications for SCAF8 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. (PMID: 11101529) Ajuh P. … Lamond A.I. (EMBO J. 2000) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SCAF8 Gene

Sources for SCAF8 Gene

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