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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SCAF8 Gene

protein-coding   GIFtS: 45
GCID: GC06P155055

SR-Related CTD-Associated Factor 8

(Previous name: RNA binding motif protein 16)
(Previous symbol: RBM16)
  Search for SCAF8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SR-Related CTD-Associated Factor 81 2     Protein SCAF82
RBM161 2 3     Putative RNA-Binding Protein 162
RNA Binding Motif Protein 161 2     RNA-Binding Protein 162
CDC5L Complex-Associated Protein 72 3     SR-Like CTD-Associated Factor 82
RNA-Binding Motif Protein 162 3     CCAP73
SR-Related And CTD-Associated Factor 82 3     KIAA11163

External Ids:    HGNC: 209591   Entrez Gene: 228282   Ensembl: ENSG000002130797   UniProtKB: Q9UPN63   

Export aliases for SCAF8 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SCAF8 Gene: 
SCAF8 (SR-related CTD-associated factor 8) is a protein-coding gene. GO annotations related to this gene include RNA polymerase core enzyme binding and RNA binding. An important paralog of this gene is SCAF4.

UniProtKB/Swiss-Prot: SCAF8_HUMAN, Q9UPN6
Function: May play a role in mRNA processing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SCAF8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCAF8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SCAF8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SCAF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1-q25.3   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q25.1-q25.3

SCAF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCAF8 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P155055:  view genomic region     (about GC identifiers)

Start:
155,054,459 bp from pter      End:
155,155,194 bp from pter
Size:
100,736 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SCAF8_HUMAN, Q9UPN6 (See protein sequence)
Recommended Name: Protein SCAF8  
Size: 1271 amino acids; 140519 Da
Subunit: Interacts with POLR2A (via C-terminus). Has much higher affinity for phosphorylated POLR2A. Identified in
a complex with CDC5L and other spliceosomal proteins. May associate with the spliceosome
Subcellular location: Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of
active transcription (By similarity)
Sequence caution: Sequence=BAA83068.2; Type=Erroneous initiation;
6/9 PDB 3D structures from and Proteopedia for SCAF8 (see all 9):
2DIW (3D)        3D9I (3D)        3D9J (3D)        3D9K (3D)        3D9L (3D)        3D9M (3D)    
Secondary accessions: Q5TBU6 Q6NSK3 Q9BQN8 Q9BX43

Explore the universe of human proteins at neXtProt for SCAF8: NX_Q9UPN6

Explore proteomics data for SCAF8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPN6

  • SCAF8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SCAF8 Protein Expression
    REFSEQ proteins: NP_055707.3  
    ENSEMBL proteins: 
     ENSP00000356146   ENSP00000356154   ENSP00000413098  

    Human Recombinant Protein Products for SCAF8: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCAF8 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0016363nuclear matrix ISS--

    SCAF8 for ontologies           About GeneDecksing



    SCAF8 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    5 InterPro protein domains:
     IPR006903 RNA_pol_II-bd
     IPR006569 CID_dom
     IPR008942 ENTH_VHS
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9UPN6

    ProtoNet protein and cluster: Q9UPN6

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB006569 Regulation of nuclear pre-mRNA protein


    UniProtKB/Swiss-Prot: SCAF8_HUMAN, Q9UPN6
    Similarity: Contains 1 CID domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    SCAF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCAF8_HUMAN, Q9UPN6
    Function: May play a role in mRNA processing

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0043175RNA polymerase core enzyme binding IPI18550522
         
    SCAF8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SCAF8:
     Decreased cell number, increas 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SCAF8 
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    SwitchGear 3'UTR luciferase reporter plasmidSCAF8 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAF8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SCAF8

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/555 Interacting proteins for SCAF8 (Q9UPN62, 3 ENSP000003561464) via UniProtKB, MINT, STRING, and/or I2D (see all 555)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, 3, ENSP000003605324MINT-7947479 I2D: score=1 STRING: ENSP00000360532
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTBP607092MINT-7947479
    ACTL6AO960192MINT-7947479
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    SCAF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SCAF8

    Search CenterWatch for drugs/clinical trials and news about SCAF8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SCAF8 gene: 
    NM_014892.3  

    Unigene Cluster for SCAF8:

    SR-related CTD-associated factor 8
    Hs.591329  [show with all ESTs]
    Unigene Representative Sequence: NM_014892
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367178(uc011efk.2 uc003qqa.3 uc003qpz.3) ENST00000461219
    ENST00000464628 ENST00000479234 ENST00000367186(uc011efj.2 uc010kji.3)
    ENST00000417268
    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SCAF8 (see all 31):
    hsa-miR-549 hsa-miR-361-5p hsa-miR-300 hsa-miR-520d-5p hsa-miR-509-5p hsa-miR-216b hsa-miR-944 hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidSCAF8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SCAF8 (NM_014892)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAF8
    Sirion Biotech Customized lentivirus for stable overexpression of SCAF8 
                         Customized lentivirus expression plasmids for stable overexpression of SCAF8 
    Primer
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    OriGene qPCR primer pairs and template standards for SCAF8
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    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SCAF8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SCAF8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SCAF8

    Additional mRNA sequence: 

    AB029039.1 AK001530.1 AK023859.1 AK295651.1 AK302969.1 AK303001.1 AK307815.1 AL833928.1 
    BC032728.1 BC070071.1 

    13 DOTS entries:

    DT.213252  DT.101967195  DT.91645339  DT.92449365  DT.101983395  DT.121368960  DT.121369039  DT.91982659 
    DT.95157459  DT.100688099  DT.121369095  DT.40286849  DT.86857088 

    24/214 AceView cDNA sequences (see all 214):

    BQ268011 BG259907 AA404703 NM_014892 BQ440965 CA313156 BQ774192 AL110372 
    AU141167 AI276470 AA443117 AA743403 BP357758 BC070071 AK023859 BX090356 
    N35565 CB242615 BM460025 CA337351 AB029039 BQ437404 AA890112 AA404253 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SCAF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGGTAAAC
    SCAF8 Expression
    About this image


    See SCAF8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SCAF8

    SOURCE GeneReport for Unigene cluster: Hs.591329
        SABiosciences Custom PCR Arrays for SCAF8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SCAF8 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scaf81 , 5 SR-related CTD-associated factor 81, 5 88.56(n)1
    91.64(a)1
      17 (1.96 cM)5
    1065831  NM_134123.31  NP_598884.21 
     31149725 
    chicken
    (Gallus gallus)
    Aves SCAF86
    Uncharacterized protein
    79(a)
    1 ↔ 1
    3(49604475-49635861)
    lizard
    (Anolis carolinensis)
    Reptilia SCAF86
    Uncharacterized protein
    75(a)
    1 ↔ 1
    1(214888798-214921536)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480146532   -- 84.22(n)    48014653 
    zebrafish
    (Danio rerio)
    Actinopterygii 570596662   -- 76.86(n)    57059666 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG42666
    --
    21(a)
    1 → many
    2R(17049218-17056163)
    worm
    (Caenorhabditis elegans)
    Secernentea nrd-16
    Protein NRD-1
    19(a)
    1 → many
    I(4597890-4602666)


    ENSEMBL Gene Tree for SCAF8 (if available)
    TreeFam Gene Tree for SCAF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SCAF8 gene
    SCAF42  
    4 SIMAP similar genes for SCAF8 using alignment to 2 protein entries:     SCAF8_HUMAN (see all proteins):
    DKFZp434J2412    RBM16    SFRS15    SCAF4

    SCAF8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2225 SNPs in SCAF8 are shown (see all 2225)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798559141,2
    C--152664267(+) AACAC-/AT/TA 
            
    AGGTT
    1 -- int10--------
    rs1444161701,2
    --155052538(+) TCTTTG/TTGAGA 1 -- us2k10--------
    rs1487953741,2
    --155052596(+) CGGCAC/TGCTGC 1 -- us2k10--------
    rs1918978451,2
    --155052647(+) CCTCCC/GGAGTA 1 -- us2k10--------
    rs1438629911,2
    --155052680(+) ACCACA/GCCTGG 1 -- us2k10--------
    rs730090011,2
    C,F--155052906(+) TGCTCC/GTTTAG 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1125611931,2
    C,F--155053105(+) AGCTGC/TGGCAG 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1826316261,2
    --155053170(+) ATGAGA/GAAGTA 1 -- us2k10--------
    rs1397931321,2
    --155053174(+) GAAAGC/TATTTA 1 -- us2k10--------
    rs1148414991,2
    F--155053176(+) AAGTAT/CTTAAG 1 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for SCAF8 (155054459 - 155155194 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SCAF8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674803CNV Deletion23128226
    nsv886788CNV Loss21882294
    esv23624CNV Loss19812545
    nsv823882CNV Loss20364138
    nsv5551CNV Loss18451855
    esv32566CNV Loss17666407
    esv275420CNV Gain+Loss21479260

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SCAF8
    DNA2.0 Custom Variant and Variant Library Synthesis for SCAF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SCAF8 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with SCAF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
    2. Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxyl-terminal domain of RNA polymerase II. (PubMed id 18550522)1, 2 Becker R....Meinhart A. (2008)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. (PubMed id 11101529)1, 2 Ajuh P....Lamond A.I. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22828 HGNC: 20959 AceView: RBM16 Ensembl:ENSG00000213079 euGenes: HUgn22828
    ECgene: SCAF8 H-InvDB: SCAF8

    (According to HUGE)
    About This Section
    HUGE: KIAA1116

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SCAF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SCAF8 gene:
    Search GeneIP for patents involving SCAF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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