Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SCAF8 Gene

protein-coding   GIFtS: 46
GCID: GC06P155055

SR-Related CTD-Associated Factor 8

(Previous name: RNA binding motif protein 16)
(Previous symbol: RBM16)
  Search for SCAF8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SR-Related CTD-Associated Factor 81 2     RNA Binding Motif Protein 161
RBM161 2 3     Protein SCAF82
CDC5L Complex-Associated Protein 72 3     SR-Like CTD-Associated Factor 82
RNA-Binding Motif Protein 162 3     CCAP73
SR-Related And CTD-Associated Factor 82 3     KIAA11163

External Ids:    HGNC: 209591   Entrez Gene: 228282   Ensembl: ENSG000002130797   UniProtKB: Q9UPN63   

Export aliases for SCAF8 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SCAF8 Gene:
SCAF8 (SR-related CTD-associated factor 8) is a protein-coding gene. GO annotations related to this gene include RNA polymerase core enzyme binding and RNA binding. An important paralog of this gene is SCAF4.

UniProtKB/Swiss-Prot: SCAF8_HUMAN, Q9UPN6
Function: May play a role in mRNA processing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SCAF8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCAF8 promoter sequence
   Search Chromatin IP Primers for SCAF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCAF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1-q25.3   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q25.1-q25.3

SCAF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCAF8 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P155055:  view genomic region     (about GC identifiers)

Start:
155,054,459 bp from pter      End:
155,155,194 bp from pter
Size:
100,736 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SCAF8_HUMAN, Q9UPN6 (See protein sequence)
Recommended Name: Protein SCAF8  
Size: 1271 amino acids; 140519 Da
Subunit: Interacts with POLR2A (via C-terminus). Has much higher affinity for phosphorylated POLR2A. Identified in
a complex with CDC5L and other spliceosomal proteins. May associate with the spliceosome
Sequence caution: Sequence=BAA83068.2; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for SCAF8 (see all 9):
2DIW (3D)        3D9I (3D)        3D9J (3D)        3D9K (3D)        3D9L (3D)        3D9M (3D)    
Secondary accessions: Q5TBU6 Q6NSK3 Q9BQN8 Q9BX43

Explore the universe of human proteins at neXtProt for SCAF8: NX_Q9UPN6

Explore proteomics data for SCAF8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys119
  • Modification sites at PhosphoSitePlus

  • See SCAF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001273117.1  NP_001273118.1  NP_001273123.1  NP_001273128.1  NP_055707.3  

    ENSEMBL proteins: 
     ENSP00000356146   ENSP00000356154   ENSP00000413098  

    SCAF8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SCAF8
    GenScript Custom Purified and Recombinant Proteins Services for SCAF8
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SCAF8

    SCAF8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SCAF8
    Novus Biologicals SCAF8 Antibodies
    Abcam antibodies for SCAF8
    Cloud-Clone Corp. Antibodies for SCAF8
    Search ThermoFisher Antibodies for SCAF8
    LSBio Antibodies in human, mouse, rat for SCAF8

    SCAF8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SCAF8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SCAF8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SCAF8
    Cloud-Clone Corp. CLIAs for SCAF8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    5 InterPro protein domains:
     IPR006569 CID_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR006903 RNA_pol_II-bd
     IPR008942 ENTH_VHS
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPN6

    ProtoNet protein and cluster: Q9UPN6

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB006569 Regulation of nuclear pre-mRNA protein


    UniProtKB/Swiss-Prot: SCAF8_HUMAN, Q9UPN6
    Similarity: Contains 1 CID domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    SCAF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCAF8_HUMAN, Q9UPN6
    Function: May play a role in mRNA processing

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0043175RNA polymerase core enzyme binding IPI18550522
         
    SCAF8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SCAF8:
     Decreased cell number, increas 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCAF8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCAF8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCAF8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCAF8

    miRNA
    Products:
        
    miRTarBase miRNAs that target SCAF8:
    hsa-mir-29b-3p (MIRT048359), hsa-mir-877-3p (MIRT037053), hsa-mir-92a-3p (MIRT049583), hsa-let-7b-5p (MIRT052039)

    Block miRNA regulation of human, mouse, rat SCAF8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCAF8 (see all 31):
    hsa-miR-549 hsa-miR-361-5p hsa-miR-300 hsa-miR-520d-5p hsa-miR-509-5p hsa-miR-216b hsa-miR-944 hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidSCAF8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SCAF8
    Predesigned siRNA for gene silencing in human, mouse, rat SCAF8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SCAF8

    Clone
    Products:
         
    OriGene clones in human, mouse for SCAF8 (see all 6)
    OriGene ORF clones in mouse, rat for SCAF8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCAF8 (NM_014892)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCAF8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAF8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SCAF8
    Browse ESI BIO Cell Lines and PureStem Progenitors for SCAF8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAF8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SCAF8_HUMAN, Q9UPN6: Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of
    active transcription (By similarity)

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0016363nuclear matrix ISS--

    SCAF8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCAF8
    Interactions:

        Search GeneGlobe Interaction Network for SCAF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SCAF8 (Q9UPN62, 3 ENSP000003561464) via UniProtKB, MINT, STRING, and/or I2D (see all 710)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, 3, ENSP000003605324MINT-7947479 I2D: score=1 STRING: ENSP00000360532
    SETXQ7Z3332, ENSP000002241404MINT-7947479 STRING: ENSP00000224140
    EXOSC10Q017802, ENSP000003661354MINT-7947479 STRING: ENSP00000366135
    CDC73Q6P1J92, ENSP000003564054MINT-7947479 STRING: ENSP00000356405
    POLR1CO151602, ENSP000003614654MINT-7947479 STRING: ENSP00000361465
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    SCAF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCAF8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SCAF8 gene (5 alternative transcripts): 
    NM_001286188.1  NM_001286189.1  NM_001286194.1  NM_001286199.1  NM_014892.4  

    Unigene Cluster for SCAF8:

    SR-related CTD-associated factor 8
    Hs.591329  [show with all ESTs]
    Unigene Representative Sequence: NM_014892
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367178(uc011efk.2 uc003qqa.3 uc003qpz.3) ENST00000461219
    ENST00000464628 ENST00000479234 ENST00000367186(uc011efj.2 uc010kji.3)
    ENST00000417268
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCAF8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCAF8 (see all 31):
    hsa-miR-549 hsa-miR-361-5p hsa-miR-300 hsa-miR-520d-5p hsa-miR-509-5p hsa-miR-216b hsa-miR-944 hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidSCAF8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SCAF8
    Predesigned siRNA for gene silencing in human, mouse, rat SCAF8
    Clone
    Products:
         
    OriGene clones in human, mouse for SCAF8 (see all 6)
    OriGene ORF clones in mouse, rat for SCAF8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCAF8 (NM_014892)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCAF8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAF8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SCAF8
    OriGene qSTAR qPCR primer pairs in human, mouse for SCAF8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SCAF8
      QuantiTect SYBR Green Assays in human, mouse, rat SCAF8
      QuantiFast Probe-based Assays in human, mouse, rat SCAF8

    Additional mRNA sequence: 

    AB029039.1 AK001530.1 AK023859.1 AK295651.1 AK302969.1 AK303001.1 AK307815.1 AL833928.1 
    BC032728.1 BC070071.1 

    13 DOTS entries:

    DT.213252  DT.101967195  DT.91645339  DT.92449365  DT.101983395  DT.121368960  DT.121369039  DT.91982659 
    DT.95157459  DT.100688099  DT.121369095  DT.40286849  DT.86857088 

    Selected AceView cDNA sequences (see all 214):

    CA313156 BP357758 NM_014892 AA890112 BC070071 CB267808 AA743403 CB242615 
    AL110372 AI566987 AU141167 AB029039 BM976977 AI276470 BX090356 AL833928 
    BQ774192 BQ268011 N35565 BG259907 BM460025 BQ437404 CA337351 AA404703 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SCAF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGGTAAAC
    SCAF8 Expression
    About this image

    SCAF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCAF8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591329
        Custom PCR Arrays for SCAF8
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SCAF8
    OriGene qSTAR qPCR primer pairs in human, mouse for SCAF8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SCAF8
    QuantiTect SYBR Green Assays in human, mouse, rat SCAF8
    QuantiFast Probe-based Assays in human, mouse, rat SCAF8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SCAF8 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scaf81 , 5 SR-related CTD-associated factor 81, 5 88.56(n)1
    91.64(a)1
      17 (1.96 cM)5
    1065831  NM_134123.31  NP_598884.21 
     31149725 
    chicken
    (Gallus gallus)
    Aves SCAF81 SR-related CTD-associated factor 8 78.77(n)
    80.94(a)
      421647  XM_004935640.1  XP_004935697.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCAF86
    SR-related CTD-associated factor 8
    75(a)
    1 ↔ 1
    1(214888798-214921536)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480146532   -- 84.22(n)    48014653 
    zebrafish
    (Danio rerio)
    Actinopterygii 570596662   -- 76.86(n)    57059666 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG42666
    --
    25(a)
    1 → many
    2R(17049218-17056163)
    worm
    (Caenorhabditis elegans)
    Secernentea nrd-16
    Protein NRD-1 (nrd-1) mRNA, complete cds
    23(a)
    1 → many
    I(4597890-4602666) WBGene00017004


    ENSEMBL Gene Tree for SCAF8 (if available)
    TreeFam Gene Tree for SCAF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SCAF8 gene
    SCAF42  
    4 SIMAP similar genes for SCAF8 using alignment to 2 protein entries:     SCAF8_HUMAN (see all proteins):
    DKFZp434J2412    RBM16    SFRS15    SCAF4

    SCAF8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SCAF8 (see all 2225)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798559141,2
    C--152664267(+) AACAC-/AT/TA 
            
    AGGTT
    1 -- int10--------
    rs1444161701,2
    --155052538(+) TCTTTG/TTGAGA 1 -- us2k10--------
    rs1487953741,2
    --155052596(+) CGGCAC/TGCTGC 1 -- us2k10--------
    rs1918978451,2
    --155052647(+) CCTCCC/GGAGTA 1 -- us2k10--------
    rs1438629911,2
    --155052680(+) ACCACA/GCCTGG 1 -- us2k10--------
    rs730090011,2
    C,F--155052906(+) TGCTCC/GTTTAG 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1125611931,2
    C,F--155053105(+) AGCTGC/TGGCAG 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1826316261,2
    --155053170(+) ATGAGA/GAAGTA 1 -- us2k10--------
    rs1397931321,2
    --155053174(+) GAAAGC/TATTTA 1 -- us2k10--------
    rs1148414991,2
    F--155053176(+) AAGTAT/CTTAAG 1 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for SCAF8 (155054459 - 155155194 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SCAF8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674803CNV Deletion23128226
    nsv886788CNV Loss21882294
    esv23624CNV Loss19812545
    nsv823882CNV Loss20364138
    nsv5551CNV Loss18451855
    esv32566CNV Loss17666407
    esv275420CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCAF8
    DNA2.0 Custom Variant and Variant Library Synthesis for SCAF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SCAF8 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SCAF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R.... Ohara O. (DNA Res. 1999)
    2. Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxyl-terminal domain of RNA polymerase II. (PubMed id 18550522)1, 2 Becker R.... Meinhart A. (J. Biol. Chem. 2008)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. (PubMed id 11101529)1, 2 Ajuh P....Lamond A.I. (EMBO J. 2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22828 HGNC: 20959 AceView: RBM16 Ensembl:ENSG00000213079 euGenes: HUgn22828
    ECgene: SCAF8 H-InvDB: SCAF8

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1116

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SCAF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SCAF8 gene:
    Search GeneIP for patents involving SCAF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SCAF8  
     OriGene qPCR primer pairs and template standards for SCAF8   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SCAF8  
     OriGene qSTAR qPCR primer pairs in human, mouse for SCAF8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SCAF8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SCAF8   OriGene Custom Protein Services for SCAF8  

     
     
     Block miRNA regulation of human, mouse, rat SCAF8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SCAF8
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCAF8 Predesigned siRNA for gene silencing in human, mouse, rat SCAF8
     QuantiFast Probe-based Assays in human, mouse, rat SCAF8 QuantiTect SYBR Green Assays in human, mouse, rat SCAF8
     Custom PCR Arrays for SCAF8 Search Chromatin IP Primers for SCAF8
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SCAF8  Search GeneGlobe Interaction Network for SCAF8
     Search Regulatory tfbs for SCAF8
     GenScript Custom Purified and Recombinant Proteins Services for SCAF8 GenScript cDNA clones with any tag delivered in your preferred vector for SCAF8
     GenScript Custom Assay Services for SCAF8 GenScript Custom overexpressing Cell Line Services for SCAF8
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SCAF8
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SCAF8 antibodies
     Antibodies for SCAF8
     See all of Abcam's Antibodies, Kits and Proteins for SCAF8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SCAF8
     Antibodies for SCAF8
     ELISAs for SCAF8
     CLIAs for SCAF8



     Browse ESI BIO Cell Lines and PureStem Progenitors for SCAF8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAF8
     SwitchGear 3'UTR luciferase reporter plasmids for SCAF8
     SwitchGear Promoter luciferase reporter plasmids for SCAF8
     Search ThermoFisher Antibodies for SCAF8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAF8
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCAF8
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCAF8
     LSBio Antibodies in human, mouse, rat for SCAF8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SCAF8 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4