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Aliases for SCAF8 Gene

Aliases for SCAF8 Gene

  • SR-Related CTD-Associated Factor 8 2 3
  • SR-Related And CTD-Associated Factor 8 3 4
  • CDC5L Complex-Associated Protein 7 3 4
  • RNA-Binding Motif Protein 16 3 4
  • RBM16 3 4
  • SR-Like CTD-Associated Factor 8 3
  • RNA Binding Motif Protein 16 2
  • Protein SCAF8 3
  • KIAA1116 4
  • CCAP7 4

External Ids for SCAF8 Gene

Previous HGNC Symbols for SCAF8 Gene

  • RBM16

Previous GeneCards Identifiers for SCAF8 Gene

  • GC06P155055

Summaries for SCAF8 Gene

GeneCards Summary for SCAF8 Gene

SCAF8 (SR-Related CTD-Associated Factor 8) is a Protein Coding gene. GO annotations related to this gene include RNA binding and RNA polymerase core enzyme binding. An important paralog of this gene is SCAF4.

UniProtKB/Swiss-Prot for SCAF8 Gene

  • May play a role in mRNA processing.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAF8 Gene

Genomics for SCAF8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCAF8 Gene

154,733,325 bp from pter
154,834,244 bp from pter
100,920 bases
Plus strand

Genomic View for SCAF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCAF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAF8 Gene

No data available for Regulatory Elements for SCAF8 Gene

Proteins for SCAF8 Gene

  • Protein details for SCAF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SCAF8
    Protein Accession:
    Secondary Accessions:
    • B7Z888
    • Q5TBU6
    • Q6NSK3
    • Q9BQN8
    • Q9BX43

    Protein attributes for SCAF8 Gene

    1271 amino acids
    Molecular mass:
    140519 Da
    Quaternary structure:
    • Interacts with POLR2A (via C-terminus). Has much higher affinity for phosphorylated POLR2A. Identified in a complex with CDC5L and other spliceosomal proteins. May associate with the spliceosome.
    • Sequence=BAA83068.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCAF8 Gene

    Alternative splice isoforms for SCAF8 Gene


neXtProt entry for SCAF8 Gene

Proteomics data for SCAF8 Gene at MOPED

Post-translational modifications for SCAF8 Gene

  • Ubiquitination at Lys119
  • Modification sites at PhosphoSitePlus

Other Protein References for SCAF8 Gene

No data available for DME Specific Peptides for SCAF8 Gene

Domains for SCAF8 Gene

Gene Families for SCAF8 Gene

Suggested Antigen Peptide Sequences for SCAF8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CID domain.
  • Contains 1 CID domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with SCAF8: view

Function for SCAF8 Gene

Molecular function for SCAF8 Gene

UniProtKB/Swiss-Prot Function:
May play a role in mRNA processing.

Gene Ontology (GO) - Molecular Function for SCAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043175 RNA polymerase core enzyme binding IPI 18550522
genes like me logo Genes that share ontologies with SCAF8: view

Phenotypes for SCAF8 Gene

GenomeRNAi human phenotypes for SCAF8:
genes like me logo Genes that share phenotypes with SCAF8: view

Animal Model Products

CRISPR Products

miRNA for SCAF8 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCAF8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAF8 Gene

Localization for SCAF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAF8 Gene

Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of active transcription. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for SCAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IEA --
GO:0016363 nuclear matrix ISS --
genes like me logo Genes that share ontologies with SCAF8: view

No data available for Subcellular locations from COMPARTMENTS for SCAF8 Gene

Pathways for SCAF8 Gene

SuperPathways for SCAF8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SCAF8: view

No data available for Pathways by source for SCAF8 Gene

Transcripts for SCAF8 Gene

Unigene Clusters for SCAF8 Gene

SR-related CTD-associated factor 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCAF8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAF8 Gene

No ASD Table

Relevant External Links for SCAF8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAF8 Gene

mRNA expression in normal human tissues for SCAF8 Gene

Protein differential expression in normal tissues for SCAF8 Gene

This gene is overexpressed in Tlymphocyte (27.9) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCAF8 Gene

SOURCE GeneReport for Unigene cluster for SCAF8 Gene Hs.591329

genes like me logo Genes that share expressions with SCAF8: view

Expression partners for SCAF8 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCAF8 Gene

Orthologs for SCAF8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAF8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCAF8 35
  • 91.9 (n)
  • 95.5 (a)
SCAF8 36
  • 95 (a)
(Mus musculus)
Mammalia Scaf8 35
  • 88.56 (n)
  • 91.64 (a)
Scaf8 16
Scaf8 36
  • 91 (a)
(Pan troglodytes)
Mammalia SCAF8 35
  • 99.75 (n)
  • 99.85 (a)
SCAF8 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Scaf8 35
  • 88.22 (n)
  • 91.72 (a)
(Canis familiaris)
Mammalia KIAA1116 36
  • 96 (a)
(Monodelphis domestica)
Mammalia SCAF8 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia SCAF8 36
  • 94 (a)
(Gallus gallus)
Aves SCAF8 35
  • 78.77 (n)
  • 80.94 (a)
SCAF8 36
  • 80 (a)
(Anolis carolinensis)
Reptilia SCAF8 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scaf8 35
  • 70.76 (n)
  • 70.7 (a)
Str.3128 35
(Danio rerio)
Actinopterygii wu:fd99c08 35
  • 63.06 (n)
  • 64.05 (a)
scaf4b 36
  • 38 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6704 35
fruit fly
(Drosophila melanogaster)
Insecta CG4266 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea nrd-1 36
  • 23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7297 35
Species with no ortholog for SCAF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAF8 Gene

Gene Tree for SCAF8 (if available)
Gene Tree for SCAF8 (if available)

Paralogs for SCAF8 Gene

Paralogs for SCAF8 Gene

(4) SIMAP similar genes for SCAF8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCAF8: view

Variants for SCAF8 Gene

Sequence variations from dbSNP and Humsavar for SCAF8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9375 -- 154,833,905(-) AGACC(A/G)TAGTG utr-variant-3-prime
rs911191 -- 154,831,177(+) GGTTG(C/G)CTCTC intron-variant
rs1137816 -- 154,812,374(-) aagtg(A/T)gcaac intron-variant
rs2351845 -- 154,819,157(-) CTGAT(A/G)AGATA intron-variant
rs2351846 -- 154,817,808(-) CTCAG(A/G)AAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAF8 Gene

Variant ID Type Subtype PubMed ID
esv275420 CNV Gain+Loss 21479260
nsv886788 CNV Loss 21882294
esv23624 CNV Loss 19812545
esv2674803 CNV Deletion 23128226
esv32566 CNV Loss 17666407
nsv5551 CNV Loss 18451855
nsv823882 CNV Loss 20364138

Relevant External Links for SCAF8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAF8 Gene

Disorders for SCAF8 Gene

No disorders were found for SCAF8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SCAF8 Gene

Publications for SCAF8 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. (PMID: 11101529) Ajuh P. … Lamond A.I. (EMBO J. 2000) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for SCAF8 Gene

Sources for SCAF8 Gene

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