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SCAF4 Gene

protein-coding   GIFtS: 50
GCID: GC21M033044

SR-Related CTD-Associated Factor 4

(Previous names: splicing factor, arginine/serine-rich 15)
(Previous symbol: SFRS15)
  See SCAF4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SR-Related CTD-Associated Factor 41 2     SRA42
SFRS151 2 3     Pre-MRNA Splicing SR Protein RA42
Splicing Factor, Arginine/Serine-Rich 151 2     Splicing Factor Serine Alanine 152
CTD-Binding SR-Like Protein RA42 3     SR-Like CTD-Associated Factor 42
SR-Related And CTD-Associated Factor 42 3     KIAA11723

External Ids:    HGNC: 193041   Entrez Gene: 574662   Ensembl: ENSG000001563047   UniProtKB: O951043   

Export aliases for SCAF4 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SCAF4 Gene:
This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat
appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA
splicing. Alternatively spliced transcript variants have been described. (provided by RefSeq, Feb 2009)

GeneCards Summary for SCAF4 Gene:
SCAF4 (SR-related CTD-associated factor 4) is a protein-coding gene. Diseases associated with SCAF4 include wells syndrome. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SCAF8.

UniProtKB/Swiss-Prot: SFR15_HUMAN, O95104
Function: May act to physically and functionally link transcription and pre-mRNA processing (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SCAF4
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCAF4 promoter sequence
   Search Chromatin IP Primers for SCAF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCAF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.1   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1

SCAF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCAF4 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M033044:  view genomic region     (about GC identifiers)

Start:
33,043,313 bp from pter      End:
33,104,431 bp from pter
Size:
61,119 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SFR15_HUMAN, O95104 (See protein sequence)
Recommended Name: Splicing factor, arginine/serine-rich 15  
Size: 1147 amino acids; 125869 Da
Subunit: Interacts with the repetitive C-terminal domain (CTD) of RNA polymerase II (By similarity)
Sequence caution: Sequence=AAD09327.1; Type=Erroneous initiation;
Secondary accessions: C9JLZ0 Q0P5W8 Q6P1M5 Q8N3I8 Q9UFM1 Q9ULP8
Alternative splicing: 3 isoforms:  O95104-1   O95104-2   O95104-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SCAF4: NX_O95104

Explore proteomics data for SCAF4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys119, Lys583
  • Modification sites at PhosphoSitePlus

  • See SCAF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138916.1  NP_001138917.1  NP_065757.1  

    ENSEMBL proteins: 
     ENSP00000286835   ENSP00000382703   ENSP00000402377  

    SCAF4 Human Recombinant Protein Products:

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    Novus Biologicals SCAF4 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    5 InterPro protein domains:
     IPR006569 CID_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR006903 RNA_pol_II-bd
     IPR008942 ENTH_VHS
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O95104

    ProtoNet protein and cluster: O95104

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB006569 Regulation of nuclear pre-mRNA protein


    UniProtKB/Swiss-Prot: SFR15_HUMAN, O95104
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 CID domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with SCAF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFR15_HUMAN, O95104
    Function: May act to physically and functionally link transcription and pre-mRNA processing (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SCAF4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SCAF4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCAF4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCAF4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCAF4

    miRNA
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    miRTarBase miRNAs that target SCAF4:
    hsa-let-7b-5p (MIRT032458), hsa-mir-16-5p (MIRT031980), hsa-mir-25-3p (MIRT050312), hsa-mir-331-3p (MIRT043389)

    Block miRNA regulation of human, mouse, rat SCAF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCAF4 (see all 26):
    hsa-miR-2052 hsa-miR-30c hsa-miR-185* hsa-miR-16-1* hsa-miR-30d hsa-miR-30a hsa-miR-3154 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidSCAF4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SCAF4

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    GenScript: all cDNA clones in your preferred vector (see all 3): SCAF4 (NM_020706)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCAF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAF4

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SCAF4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SFR15_HUMAN, O95104: Nucleus (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with SCAF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SCAF4
    Interactions:

        Search GeneGlobe Interaction Network for SCAF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SCAF4 (O951042, 3 ENSP000002868354) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WBP4O755542, 3, ENSP000003688014MINT-73053 I2D: score=3 STRING: ENSP00000368801
    TP63Q9H3D43, ENSP000002647314I2D: score=1 STRING: ENSP00000264731
    NCBP1ENSP000003642894STRING: ENSP00000364289
    SETXENSP000002241404STRING: ENSP00000224140
    EXOSC10ENSP000003661354STRING: ENSP00000366135
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCAF4 (SFR15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCAF4 gene (3 alternative transcripts): 
    NM_001145444.1  NM_001145445.1  NM_020706.2  

    Unigene Cluster for SCAF4:

    SR-related CTD-associated factor 4
    Hs.17255  [show with all ESTs]
    Unigene Representative Sequence: NM_020706
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286835 ENST00000399804 ENST00000434667(uc002ypd.2 uc002ype.2 uc010glu.2)
    ENST00000467731(uc002ypf.1) ENST00000472318 ENST00000485790(uc002ypg.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SCAF4 (see all 26):
    hsa-miR-2052 hsa-miR-30c hsa-miR-185* hsa-miR-16-1* hsa-miR-30d hsa-miR-30a hsa-miR-3154 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidSCAF4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SCAF4
    Predesigned siRNA for gene silencing in human, mouse, rat SCAF4
    Clone
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    OriGene clones in human, mouse for SCAF4 (see all 18)
    OriGene ORF clones in mouse, rat for SCAF4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SCAF4 (NM_020706)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCAF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAF4
    Primer
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    OriGene qPCR primer pairs and template standards for SCAF4
    OriGene qSTAR qPCR primer pairs in human, mouse for SCAF4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCAF4
      QuantiTect SYBR Green Assays in human, mouse, rat SCAF4
      QuantiFast Probe-based Assays in human, mouse, rat SCAF4

    Additional mRNA sequence: 

    AB032998.1 AF023142.1 AK025748.1 AK027017.1 AK057840.1 AK308406.1 AL117417.1 AL834304.1 
    BC014921.1 BC031898.1 BC043353.1 BC052286.1 BC064990.1 

    12 DOTS entries:

    DT.99986720  DT.109029  DT.309228  DT.100022693  DT.308140  DT.92045672  DT.92427206  DT.95276510 
    DT.407010  DT.309229  DT.95276512  DT.99994556 

    Selected AceView cDNA sequences (see all 125):

    NM_020706 AA768387 BC043353 CB154024 AK057840 AI352477 BG941180 BC031898 
    AJ712295 BC052286 BM463597 AA283161 BG942498 AI478410 AK025748 AL117417 
    AB032998 AI041854 BC014921 AL834304 CR603649 AA481081 AI377920 BM461730 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SCAF4 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15a · 15b · 15c ^
    SP1:                                                                                                                                                            
    SP2:                                                              -                                                                                             
    SP3:                                                              -                                                                                             
    SP4:                                                  -     -     -                                                                                             
    SP5:                                                              -                                                                                             

    ExUns: 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for SCAF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCAF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCTTTGT
    SCAF4 Expression
    About this image


    SCAF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SCAF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCAF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.17255
        Custom PCR Arrays for SCAF4
    Primer
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    OriGene qPCR primer pairs and template standards for SCAF4
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    QuantiTect SYBR Green Assays in human, mouse, rat SCAF4
    QuantiFast Probe-based Assays in human, mouse, rat SCAF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SCAF4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scaf41 , 5 SR-related CTD-associated factor 41, 5 88.3(n)1
    89.61(a)1
      16 (51.57 cM)5
    2244321  NM_178923.31  NP_849254.21 
     902291395 
    chicken
    (Gallus gallus)
    Aves SCAF46
    Gallus gallus SR-related CTD-associated factor 4 (...
    81(a)
    1 ↔ 1
    1(103988551-104033539)
    lizard
    (Anolis carolinensis)
    Reptilia SCAF46
    SR-related CTD-associated factor 4
    68(a)
    1 ↔ 1
    3(145613751-145659416)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia scaf41 SR-related CTD-associated factor 4 71.13(n)
    72.47(a)
      595037  NM_001030478.1  NP_001025649.1 
    zebrafish
    (Danio rerio)
    Actinopterygii scaf4a6
    SR-related CTD-associated factor 4a
    49(a)
    1 ↔ 1
    10(26335141-26351271) ENSDARG00000077093
    fruit fly
    (Drosophila melanogaster)
    Insecta CG42666
    --
    26(a)
    1 → many
    2R(17049218-17056163)
    worm
    (Caenorhabditis elegans)
    Secernentea nrd-16
    Protein NRD-1 (nrd-1) mRNA, complete cds
    27(a)
    1 → many
    I(4597890-4602666) WBGene00017004


    ENSEMBL Gene Tree for SCAF4 (if available)
    TreeFam Gene Tree for SCAF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCAF4 gene
    SCAF82  
    2 SIMAP similar genes for SCAF4 using alignment to 1 protein entry:     SFR15_HUMAN:
    SFRS15    SCAF8

    Find genes that share paralogs with SCAF4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCAF4 (see all 1418)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506516341,2
    --33042819(+) ATAAGA/GAAACA 3 -- ds50010--------
    rs1829843561,2
    --33042822(+) AGGAAA/TCAGTA 3 -- ds50010--------
    rs1873183541,2
    --33042874(+) AGGTTA/GCAAAT 3 -- ds50010--------
    rs2013553281,2
    --33042926(+) TGGTT-/GGGAAA 3 -- ds50010--------
    rs126264751,2
    C,F,H--33042929(+) GTTGGA/GAAAAA 3 -- ds500125Minor allele frequency- G:0.24NS EA NA WA 2940
    rs178803941,2
    C,F--33042931(+) TGGAAA/GAAAAA 3 -- ds50011Minor allele frequency- G:0.01NS 176
    rs1461942431,2
    C--33042947(+) CACAG-/ACACACA 3 -- ds50010--------
    rs1831392361,2
    --33042978(+) CTAACA/GTAATA 3 -- ds50010--------
    rs178843911,2
    C,F--33042985(+) AATACC/GCAGGC 3 -- ds50012Minor allele frequency- G:0.02NS WA 276
    rs1166045201,2
    --33043084(+) ACAAAA/GCCAAT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for SCAF4 (33043313 - 33104431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SCAF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2520415CNV Deletion19546169
    esv270716CNV Insertion20981092
    esv273551CNV Insertion20981092
    nsv510792CNV Loss20534489
    nsv834079CNV Loss17160897
    nsv519899CNV Gain19592680
    nsv820180CNV Gain19587683
    esv992169CNV Gain20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for SCAF4:    
    About MalaCards
    wells syndrome


    Find genes that share disorders with SCAF4           About GenesLikeMe


    Export disorders for SCAF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCAF4 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SCAF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (DNA Res. 1999)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 57466 HGNC: 19304 AceView: SFRS15 Ensembl:ENSG00000156304 euGenes: HUgn57466
    ECgene: SCAF4 H-InvDB: SCAF4

    (According to HUGE)
    About This Section

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    HUGE: KIAA1172

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SCAF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SCAF4 gene:
    Search GeneIP for patents involving SCAF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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