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Aliases for SCAF4 Gene

Aliases for SCAF4 Gene

  • SR-Related CTD Associated Factor 4 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 15 2 3
  • CTD-Binding SR-Like Protein RA4 3 4
  • SFRS15 3 4
  • SR-Related And CTD-Associated Factor 4 4
  • Splicing Factor Serine Alanine 15 3
  • Pre-MRNA Splicing SR Protein RA4 3
  • SR-Like CTD-Associated Factor 4 3
  • KIAA1172 4
  • SRA4 3

External Ids for SCAF4 Gene

Previous HGNC Symbols for SCAF4 Gene

  • SFRS15

Previous GeneCards Identifiers for SCAF4 Gene

  • GC21M033044

Summaries for SCAF4 Gene

Entrez Gene Summary for SCAF4 Gene

  • This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for SCAF4 Gene

SCAF4 (SR-Related CTD Associated Factor 4) is a Protein Coding gene. Diseases associated with SCAF4 include Hay-Wells Syndrome and Wells Syndrome. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SCAF8.

UniProtKB/Swiss-Prot for SCAF4 Gene

  • May act to physically and functionally link transcription and pre-mRNA processing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAF4 Gene

Genomics for SCAF4 Gene

Regulatory Elements for SCAF4 Gene

Enhancers for SCAF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SCAF4 on UCSC Golden Path with GeneCards custom track

Promoters for SCAF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCAF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCAF4 Gene

Chromosome:
21
Start:
31,671,000 bp from pter
End:
31,732,118 bp from pter
Size:
61,119 bases
Orientation:
Minus strand

Genomic View for SCAF4 Gene

Genes around SCAF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAF4 Gene

Proteins for SCAF4 Gene

  • Protein details for SCAF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95104-SFR15_HUMAN
    Recommended name:
    Splicing factor, arginine/serine-rich 15
    Protein Accession:
    O95104
    Secondary Accessions:
    • C9JLZ0
    • Q0P5W8
    • Q6P1M5
    • Q8N3I8
    • Q9UFM1
    • Q9ULP8

    Protein attributes for SCAF4 Gene

    Size:
    1147 amino acids
    Molecular mass:
    125869 Da
    Quaternary structure:
    • Interacts with the repetitive C-terminal domain (CTD) of RNA polymerase II.
    SequenceCaution:
    • Sequence=AAD09327.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SCAF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAF4 Gene

Post-translational modifications for SCAF4 Gene

  • Ubiquitination at Lys 119 and Lys 583
  • Modification sites at PhosphoSitePlus

Other Protein References for SCAF4 Gene

No data available for DME Specific Peptides for SCAF4 Gene

Domains & Families for SCAF4 Gene

Gene Families for SCAF4 Gene

Suggested Antigen Peptide Sequences for SCAF4 Gene

Graphical View of Domain Structure for InterPro Entry

O95104

UniProtKB/Swiss-Prot:

SFR15_HUMAN :
  • Contains 1 CID domain.
  • Belongs to the splicing factor SR family.
Domain:
  • Contains 1 CID domain.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SCAF4: view

Function for SCAF4 Gene

Molecular function for SCAF4 Gene

UniProtKB/Swiss-Prot Function:
May act to physically and functionally link transcription and pre-mRNA processing.

Gene Ontology (GO) - Molecular Function for SCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with SCAF4: view
genes like me logo Genes that share phenotypes with SCAF4: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAF4 Gene

Localization for SCAF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAF4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCAF4 Gene COMPARTMENTS Subcellular localization image for SCAF4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SCAF4: view

Pathways & Interactions for SCAF4 Gene

SuperPathways for SCAF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAF4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCAF4 Gene

Drugs & Compounds for SCAF4 Gene

No Compound Related Data Available

Transcripts for SCAF4 Gene

Unigene Clusters for SCAF4 Gene

SR-related CTD-associated factor 4:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAF4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15a · 15b · 15c ^
SP1:
SP2: -
SP3: -
SP4: - - -
SP5: -
SP6:
SP7: -
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:

ExUns: 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12: - -
SP13:

Relevant External Links for SCAF4 Gene

GeneLoc Exon Structure for
SCAF4
ECgene alternative splicing isoforms for
SCAF4

Expression for SCAF4 Gene

mRNA expression in normal human tissues for SCAF4 Gene

Protein differential expression in normal tissues from HIPED for SCAF4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.1), Urine (8.1), and Blymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCAF4 Gene



Protein tissue co-expression partners for SCAF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCAF4 Gene:

SCAF4

SOURCE GeneReport for Unigene cluster for SCAF4 Gene:

Hs.17255
genes like me logo Genes that share expression patterns with SCAF4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCAF4 Gene

Orthologs for SCAF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAF4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCAF4 34
  • 90.51 (n)
  • 93.08 (a)
SCAF4 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCAF4 34
  • 92.24 (n)
  • 94.58 (a)
SCAF4 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scaf4 34
  • 88.3 (n)
  • 89.61 (a)
Scaf4 16
Scaf4 35
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCAF4 34
  • 99.85 (n)
  • 100 (a)
SCAF4 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scaf4 34
  • 83.63 (n)
  • 84.52 (a)
oppossum
(Monodelphis domestica)
Mammalia SCAF4 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCAF4 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCAF4 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAF4 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scaf4 34
  • 71.13 (n)
  • 72.47 (a)
zebrafish
(Danio rerio)
Actinopterygii scaf4a 35
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4266 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nrd-1 35
  • 27 (a)
OneToMany
Species where no ortholog for SCAF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAF4 Gene

ENSEMBL:
Gene Tree for SCAF4 (if available)
TreeFam:
Gene Tree for SCAF4 (if available)

Paralogs for SCAF4 Gene

Paralogs for SCAF4 Gene

(2) SIMAP similar genes for SCAF4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCAF4: view

Variants for SCAF4 Gene

Sequence variations from dbSNP and Humsavar for SCAF4 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs12152067 - 31,672,306(+) CAGTA(G/T)ATGGT reference, missense
rs394151 -- 31,721,783(+) GTGCA(A/C)AGGCA intron-variant
rs7277149 -- 31,722,774(+) attga(A/G)aaacc intron-variant
rs2070423 -- 31,691,041(+) CATTC(C/T)GACTC intron-variant
rs2173963 -- 31,690,119(-) AACGT(A/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAF4 Gene

Variant ID Type Subtype PubMed ID
esv2520415 CNV deletion 19546169
esv3306440 CNV mobile element insertion 20981092
esv3309278 CNV mobile element insertion 20981092
esv3324185 CNV insertion 20981092
esv3394837 CNV insertion 20981092
esv3450908 CNV insertion 20981092
esv3575385 CNV gain 25503493
esv992169 CNV gain 20482838
nsv1067151 CNV gain 25217958
nsv1123552 CNV deletion 24896259
nsv510792 CNV deletion 20534489
nsv519899 CNV gain 19592680
nsv820180 CNV gain 19587683
nsv834079 CNV loss 17160897
nsv953354 CNV duplication 24416366

Variation tolerance for SCAF4 Gene

Residual Variation Intolerance Score: 6.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCAF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCAF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAF4 Gene

Disorders for SCAF4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SCAF4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hay-wells syndrome
  • ankyloblepharon ectodermal defects cleft lip/palate
wells syndrome
  • eosinophilic cellulitis
- elite association - COSMIC cancer census association via MalaCards
Search SCAF4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCAF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCAF4
genes like me logo Genes that share disorders with SCAF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCAF4 Gene

Publications for SCAF4 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 65
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for SCAF4 Gene

Sources for SCAF4 Gene

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