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SCAF11 Gene

protein-coding   GIFtS: 49
GCID: GC12M046313

SR-Related CTD-Associated Factor 11

(Previous names: splicing factor, arginine/serine-rich 2, interacting protein,...)
(Previous symbols: SFRS2IP, SRSF2IP)
  Search for SCAF11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SR-Related CTD-Associated Factor 111 2     Splicing Regulatory Protein 1292 3
SFRS2IP1 2 3 5     CTD-Associated SR Protein 112 3
SRSF2IP1 2 3     SC35-Interacting Protein 12 3
CASP112 3 5     SR-Related And CTD-Associated Factor 112 3
SIP12 3 5     SRSF2-Interacting Protein2 3
Serine/Arginine-Rich Splicing Factor 2, Interacting Protein1 2     SRRP1292 5
Splicing Factor, Arginine/Serine-Rich 2, Interacting Protein1 2     Protein SCAF112
Renal Carcinoma Antigen NY-REN-402 3     SFRS2-Interacting Protein2
Serine/Arginine-Rich Splicing Factor 2-Interacting Protein2 3     SRrp1293
Splicing Factor, Arginine/Serine-Rich 2-Interacting Protein2 3     

External Ids:    HGNC: 107841   Entrez Gene: 91692   Ensembl: ENSG000001392187   OMIM: 6036685   UniProtKB: Q995903   

Export aliases for SCAF11 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SCAF11 Gene:
SCAF11 (SR-related CTD-associated factor 11) is a protein-coding gene. An important paralog of this gene is SCAF1.

UniProtKB/Swiss-Prot: SCAFB_HUMAN, Q99590
Function: Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly

Gene Wiki entry for SCAF11 (SFRS2IP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SCAF11
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSCAF11 promoter sequence
   Search Chromatin IP Primers for SCAF11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SCAF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q13.11

SCAF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SCAF11 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M046313:  view genomic region     (about GC identifiers)

Start:
46,312,914 bp from pter      End:
46,385,903 bp from pter
Size:
72,990 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SCAFB_HUMAN, Q99590 (See protein sequence)
Recommended Name: Protein SCAF11  
Size: 1463 amino acids; 164652 Da
Subunit: Interacts with SRSF2/SFRS2, U2AF2 and SNRNP70
Sequence caution: Sequence=AAC39565.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC39565.1; Type=Frameshift; Positions=62; Sequence=AAH40951.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAH40951.1; Type=Miscellaneous discrepancy; Note=Contaminating
sequence. Potential poly-A sequence;
Secondary accessions: A6NEU9 A6NLW5 Q8IW59
Alternative splicing: 2 isoforms:  Q99590-1   Q99590-2   

Explore the universe of human proteins at neXtProt for SCAF11: NX_Q99590

Explore proteomics data for SCAF11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys120, Lys129, Lys165, Lys285, Lys1152
  • Modification sites at PhosphoSitePlus

  • See SCAF11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004710.2  
    ENSEMBL proteins: 
     ENSP00000449812   ENSP00000358374   ENSP00000448864   ENSP00000446746   ENSP00000266589  
     ENSP00000378840   ENSP00000378839   ENSP00000413036  

    SCAF11 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SCAF11 

    SCAF11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SCAF11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry Q99590

    ProtoNet protein and cluster: Q99590

    UniProtKB/Swiss-Prot: SCAFB_HUMAN, Q99590
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with SCAF11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCAFB_HUMAN, Q99590
    Function: Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI9447963
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with SCAF11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SCAF11:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SCAF11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SCAF11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SCAF11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SCAF11

    miRNA
    Products:
        
    miRTarBase miRNAs that target SCAF11:
    hsa-mir-1 (MIRT023662), hsa-mir-29c-3p (MIRT020370), hsa-mir-21-5p (MIRT030721), hsa-mir-124-3p (MIRT022456)

    Block miRNA regulation of human, mouse, rat SCAF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCAF11 (see all 65):
    hsa-miR-323-3p hsa-miR-199a-3p hsa-miR-411 hsa-miR-15a hsa-miR-4325 hsa-miR-200b hsa-miR-92b hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidSCAF11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SCAF11
    Predesigned siRNA for gene silencing in human, mouse, rat SCAF11

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SCAF11

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    OriGene ORF clones in mouse, rat for SCAF11
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    GenScript: all cDNA clones in your preferred vector: SCAF11 (NM_004719)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCAF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAF11

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SCAF11 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAF11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCAFB_HUMAN, Q99590: Nucleus

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with SCAF11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SCAF11: 
              Prostate Cancer in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SCAF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SCAF11 (Q995902, 3 ENSP000003583744) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSEN1P497683, ENSP000003263664I2D: score=2 STRING: ENSP00000326366
    SNRNP70P086213, ENSP000002214484I2D: score=2 STRING: ENSP00000221448
    SRSF1Q079553, ENSP000002589624I2D: score=2 STRING: ENSP00000258962
    SRSF2Q011303, ENSP000003508774I2D: score=2 STRING: ENSP00000350877
    U2AF2P263683, ENSP000003078634I2D: score=3 STRING: ENSP00000307863
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly IDA9447963
    GO:0000375RNA splicing, via transesterification reactions IDA9447963
    GO:0006397mRNA processing TAS9447963
    GO:0008380RNA splicing IDA9447963

    Find genes that share ontologies with SCAF11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SCAF11 (SCAFB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SCAF11 gene: 
    NM_004719.2  

    Unigene Cluster for SCAF11:

    SR-related CTD-associated factor 11
    Hs.210367  [show with all ESTs]
    Unigene Representative Sequence: NM_004719
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000547654 ENST00000550629 ENST00000465950(uc001row.3) ENST00000369367(uc001rox.3)
    ENST00000549162 ENST00000550893 ENST00000547950 ENST00000547018 ENST00000484275
    ENST00000546534 ENST00000551391 ENST00000266589(uc009zki.1) ENST00000395454(uc001roz.3)
    ENST00000395453 ENST00000474828 ENST00000419565(uc001roy.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SCAF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SCAF11 (see all 65):
    hsa-miR-323-3p hsa-miR-199a-3p hsa-miR-411 hsa-miR-15a hsa-miR-4325 hsa-miR-200b hsa-miR-92b hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidSCAF11 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SCAF11
    Predesigned siRNA for gene silencing in human, mouse, rat SCAF11
    Clone
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    OriGene clones in human, mouse for SCAF11 (see all 7)
    OriGene ORF clones in mouse, rat for SCAF11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SCAF11 (NM_004719)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SCAF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SCAF11
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SCAF11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCAF11
      QuantiTect SYBR Green Assays in human, mouse, rat SCAF11
      Search QuantiFast Probe-based Assays in human, mouse, rat SCAF11

    Additional mRNA sequence: 

    AF030234.1 AF147405.1 AK025132.1 AK026473.1 AK302999.1 AK314093.1 BC017465.2 BC017851.1 
    BC020736.1 BC033589.1 BC040951.2 Y11251.1 

    Selected DOTS entries (see all 26):

    DT.95173060  DT.95173064  DT.65284593  DT.116441  DT.91730580  DT.430448  DT.450172  DT.100812159 
    DT.40206920  DT.75146962  DT.91852578  DT.121206503  DT.92441784  DT.100812162  DT.75150621  DT.95147755 
    DT.95173063  DT.100029012  DT.102833132  DT.121206465  DT.121206470  DT.40200312  DT.99951848  DT.75150575 

    Selected AceView cDNA sequences (see all 460):

    N41605 BM745644 AI926706 AI434429 BM722167 BM841613 AA889214 T34545 
    CA444135 AA319947 AW964503 AA461606 AK096682 BU608026 T68912 BG413396 
    BU161456 AA971089 AI819214 BM982963 BX472543 AA478519 AA604972 CD723638 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SCAF11 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
    SP1:                                                                                                                                                            
    SP2:                    -                 -     -     -     -                                                                                                   
    SP3:                                      -     -     -     -                                                                                                   
    SP4:                    -                 -     -     -                                                                                                         
    SP5:                    -                 -     -                                                                                                               

    ExUns: 21
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SCAF11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SCAF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATATTGTT
    SCAF11 Expression
    About this image


    SCAF11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Limb (Muscoskeletal System)
    SCAF11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SCAF11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.210367

    UniProtKB/Swiss-Prot: SCAFB_HUMAN, Q99590
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including SCAF11: 
              Prostate Cancer in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SCAF11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SCAF11
    QuantiTect SYBR Green Assays in human, mouse, rat SCAF11
    Search QuantiFast Probe-based Assays in human, mouse, rat SCAF11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SCAF11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SCAF11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Scaf111 , 5 SR-related CTD-associated factor 111, 5 78.54(n)1
    71.11(a)1
      15 (52.44 cM)5
    721931  NM_028148.21  NP_082424.21 
     964116985 
    chicken
    (Gallus gallus)
    Aves SCAF111 SR-related CTD-associated factor 11 65.4(n)
    55.37(a)
      417805  NM_001195570.2  NP_001182499.1 
    lizard
    (Anolis carolinensis)
    Reptilia SCAF116
    SR-related CTD-associated factor 11
    44(a)
    1 ↔ 1
    5(53575412-53608392)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.13202 Transcribed sequence with weak similarity to protein more 80.1(n)    142024020 
    zebrafish
    (Danio rerio)
    Actinopterygii scaf116
    SR-related CTD-associated factor 11
    25(a)
    1 ↔ 1
    4(1478639-1499411) ENSDARG00000045885
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29266
    --
    8(a)
    1 → many
    3R(1405023-1414097)


    ENSEMBL Gene Tree for SCAF11 (if available)
    TreeFam Gene Tree for SCAF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SCAF11 gene
    SCAF12  PHRF12  
    3 SIMAP similar genes for SCAF11 using alignment to 5 protein entries:     SCAFB_HUMAN (see all proteins):
    SFRS2IP    PHRF1    RNF181

    Find genes that share paralogs with SCAF11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SCAF11 (see all 1373)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011100821,2
    --46312497(+) AAAAG-/AAAAAA 1 -- ds50010--------
    rs1926501751,2
    --46312577(+) GTCAAC/GTGAAA 1 -- ds50010--------
    rs1822502461,2
    --46312704(+) TTTCTA/GATTTC 1 -- ds50010--------
    rs1128677151,2
    C--46312772(+) TCTAAGCTT/-  
            
    GCTTT
    1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs104922491,2
    C,F,H--46312816(+) AATGAC/TTGGTA 1 -- ds500119Minor allele frequency- T:0.01NS EA NA 1526
    rs1868984791,2
    --46313055(+) TCTGAA/GGCTAC 1 -- ut310--------
    rs799019011,2
    C,F--46313187(+) GATAAC/GTACTA 1 -- ut311Minor allele frequency- G:0.03NA 120
    rs1477272151,2
    --46313208(+) AATTCC/TAGGCA 1 -- ut310--------
    rs1916924291,2
    --46313253(+) TTAACA/GGGACC 1 -- ut310--------
    rs1412290621,2
    --46313411(+) CAACAC/TAAAGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SCAF11 (46312914 - 46385903 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SCAF11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832397CNV Loss17160897
    dgv508e1CNV Complex17122850
    esv8720OTHER Inversion19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SCAF11
    DNA2.0 Custom Variant and Variant Library Synthesis for SCAF11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603668    OMIM disorders: --


    Find genes that share disorders with SCAF11           About GenesLikeMe


    Export disorders for SCAF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SCAF11 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SCAF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. (PubMed id 9447963)1, 2, 3 Zhang W.-J. and Wu J.Y. (Mol. Cell. Biol. 1998)
    2. A novel SR-related protein specifically interacts with the carboxy- terminal domain (CTD) of RNA polymerase II through a conserved interaction domain. (PubMed id 9224939)1, 2, 3 Tanner S.... Bourquin J.-P. (Biol. Chem. 1997)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9169 HGNC: 10784 AceView: SFRS2IP Ensembl:ENSG00000139218 euGenes: HUgn9169
    ECgene: SCAF11 H-InvDB: SCAF11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SCAF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SCAF11 gene:
    Search GeneIP for patents involving SCAF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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