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Aliases for SCAF11 Gene

Aliases for SCAF11 Gene

  • SR-Related CTD-Associated Factor 11 2 3
  • SFRS2IP 3 4 6
  • SRRP129 3 4 6
  • CASP11 3 4 6
  • SIP1 3 4 6
  • Splicing Factor, Arginine/Serine-Rich 2, Interacting Protein 2 3
  • Serine/Arginine-Rich Splicing Factor 2, Interacting Protein 2 3
  • Splicing Factor, Arginine/Serine-Rich 2-Interacting Protein 3 4
  • Serine/Arginine-Rich Splicing Factor 2-Interacting Protein 3 4
  • SR-Related And CTD-Associated Factor 11 3 4
  • Renal Carcinoma Antigen NY-REN-40 3 4
  • Splicing Regulatory Protein 129 3 4
  • CTD-Associated SR Protein 11 3 4
  • SC35-Interacting Protein 1 3 4
  • SRSF2-Interacting Protein 3 4
  • SRSF2IP 3 4
  • SFRS2-Interacting Protein 3
  • Protein SCAF11 3

External Ids for SCAF11 Gene

Previous Symbols for SCAF11 Gene

  • SFRS2IP
  • SRSF2IP

Summaries for SCAF11 Gene

GeneCards Summary for SCAF11 Gene

SCAF11 (SR-Related CTD-Associated Factor 11) is a Protein Coding gene. An important paralog of this gene is SCAF1.

UniProtKB/Swiss-Prot for SCAF11 Gene

  • Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly.

Gene Wiki entry for SCAF11 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAF11 Gene

Genomics for SCAF11 Gene

Genomic Location for SCAF11 Gene

Start:
45,919,131 bp from pter
End:
45,992,120 bp from pter
Size:
72,990 bases
Orientation:
Minus strand

Genomic View for SCAF11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCAF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAF11 Gene

No data available for Regulatory Elements for SCAF11 Gene

Proteins for SCAF11 Gene

  • Protein details for SCAF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99590-SCAFB_HUMAN
    Recommended name:
    Protein SCAF11
    Protein Accession:
    Q99590
    Secondary Accessions:
    • A6NEU9
    • A6NLW5
    • Q8IW59

    Protein attributes for SCAF11 Gene

    Size:
    1463 amino acids
    Molecular mass:
    164652 Da
    Quaternary structure:
    • Interacts with SRSF2/SFRS2, U2AF2 and SNRNP70.
    SequenceCaution:
    • Sequence=AAC39565.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC39565.1; Type=Frameshift; Positions=62; Evidence={ECO:0000305}; Sequence=AAH40951.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH40951.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for SCAF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAF11 Gene

Proteomics data for SCAF11 Gene at MOPED

Post-translational modifications for SCAF11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys120, Lys129, Lys165, Lys285, and Lys1152

No data available for DME Specific Peptides for SCAF11 Gene

Domains for SCAF11 Gene

Gene Families for SCAF11 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for SCAF11 Gene

Suggested Antigen Peptide Sequences for SCAF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99590

UniProtKB/Swiss-Prot:

SCAFB_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q99590
genes like me logo Genes that share domains with SCAF11: view

Function for SCAF11 Gene

Molecular function for SCAF11 Gene

UniProtKB/Swiss-Prot Function: Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly.

Gene Ontology (GO) - Molecular Function for SCAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9447963
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with SCAF11: view

Phenotypes for SCAF11 Gene

GenomeRNAi human phenotypes for SCAF11:
genes like me logo Genes that share phenotypes with SCAF11: view

miRNA for SCAF11 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCAF11 Gene

Localization for SCAF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAF11 Gene

Gene Ontology (GO) - Cellular Components for SCAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SCAF11: view

No data available for Subcellular locations from COMPARTMENTS for SCAF11 Gene

Pathways for SCAF11 Gene

SuperPathways for SCAF11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IDA 9447963
GO:0000375 RNA splicing, via transesterification reactions IDA 9447963
GO:0006397 mRNA processing TAS 9447963
GO:0008380 RNA splicing IDA 9447963
genes like me logo Genes that share ontologies with SCAF11: view

No data available for Pathways by source for SCAF11 Gene

Transcripts for SCAF11 Gene

Unigene Clusters for SCAF11 Gene

SR-related CTD-associated factor 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCAF11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
SP1:
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7:
SP8: -
SP9: - -
SP10:

ExUns: 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SCAF11 Gene

GeneLoc Exon Structure for
SCAF11
ECgene alternative splicing isoforms for
SCAF11

Expression for SCAF11 Gene

mRNA expression in normal human tissues for SCAF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAF11 Gene

SOURCE GeneReport for Unigene cluster for SCAF11 Gene Hs.210367

mRNA Expression by UniProt/SwissProt for SCAF11 Gene

Q99590-SCAFB_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SCAF11: view

No data available for mRNA differential expression in normal tissues for SCAF11 Gene

Orthologs for SCAF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAF11 35
  • 99.54 (n)
  • 99.11 (a)
SCAF11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCAF11 35
  • 87.26 (n)
  • 80.76 (a)
SCAF11 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCAF11 35
  • 87.96 (n)
  • 82.21 (a)
SCAF11 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scaf11 35
  • 78.54 (n)
  • 71.11 (a)
Scaf11 16
Scaf11 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Scaf11 35
  • 78.4 (n)
  • 70.49 (a)
chicken
(Gallus gallus)
Aves SCAF11 35
  • 65.4 (n)
  • 55.37 (a)
SCAF11 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAF11 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1320 35
zebrafish
(Danio rerio)
Actinopterygii scaf11 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2926 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for SCAF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCAF11 Gene

ENSEMBL:
Gene Tree for SCAF11 (if available)
TreeFam:
Gene Tree for SCAF11 (if available)

Paralogs for SCAF11 Gene

Paralogs for SCAF11 Gene

Selected SIMAP similar genes for SCAF11 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SCAF11: view

Variants for SCAF11 Gene

Sequence variations from dbSNP and Humsavar for SCAF11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs724909 -- 45,929,928(-) GTTTC(A/C)ATTTT intron-variant
rs735351 -- 45,935,409(+) CCGGA(A/T)CTTAC intron-variant
rs764192 -- 45,969,244(-) CCCCG(A/C)GGCTT intron-variant
rs997307 -- 45,953,341(+) CTTAA(A/G)AGATT intron-variant
rs997308 -- 45,953,538(+) GATCC(C/T)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCAF11 Gene

Variant ID Type Subtype PubMed ID
dgv508e1 CNV Complex 17122850
nsv832397 CNV Loss 17160897
esv8720 OTHER Inversion 19470904

Relevant External Links for SCAF11 Gene

HapMap Linkage Disequilibrium report
SCAF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAF11 Gene

Disorders for SCAF11 Gene

No disorders were found for SCAF11 Gene.

No data available for UniProtKB/Swiss-Prot for SCAF11 Gene

Publications for SCAF11 Gene

  1. A novel SR-related protein specifically interacts with the carboxy- terminal domain (CTD) of RNA polymerase II through a conserved interaction domain. (PMID: 9224939) Tanner S. … Bourquin J.-P. (Biol. Chem. 1997) 2 3 4
  2. Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. (PMID: 9447963) Zhang W.-J. … Wu J.Y. (Mol. Cell. Biol. 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for SCAF11 Gene

Sources for SCAF11 Gene

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