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Aliases for SCAF1 Gene

Aliases for SCAF1 Gene

  • SR-Related CTD Associated Factor 1 2 3
  • Serine Arginine-Rich Pre-MRNA Splicing Factor SR-A1 3 4
  • SR-Related And CTD-Associated Factor 1 3 4
  • SR-Related CTD-Associated Factor 1 3 5
  • SR-Related-CTD-Associated Factor 3 4
  • SRA1 3 4
  • SCAF 3 4
  • SFRS19 4
  • SR-A1 4

External Ids for SCAF1 Gene

Previous GeneCards Identifiers for SCAF1 Gene

  • GC19P054832
  • GC19P050145
  • GC19P046523

Summaries for SCAF1 Gene

GeneCards Summary for SCAF1 Gene

SCAF1 (SR-Related CTD Associated Factor 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding and protein domain specific binding. An important paralog of this gene is SCAF11.

UniProtKB/Swiss-Prot for SCAF1 Gene

  • May function in pre-mRNA splicing.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAF1 Gene

Genomics for SCAF1 Gene

Regulatory Elements for SCAF1 Gene

Enhancers for SCAF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCAF1 on UCSC Golden Path with GeneCards custom track

Promoters for SCAF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCAF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCAF1 Gene

49,640,503 bp from pter
49,658,649 bp from pter
18,147 bases
Plus strand

Genomic View for SCAF1 Gene

Genes around SCAF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAF1 Gene

Proteins for SCAF1 Gene

  • Protein details for SCAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Splicing factor, arginine/serine-rich 19
    Protein Accession:
    Secondary Accessions:
    • Q7Z5V7
    • Q8WVA1
    • Q9NR59

    Protein attributes for SCAF1 Gene

    1312 amino acids
    Molecular mass:
    139270 Da
    Quaternary structure:
    • Interacts with POLR2A.
    • Sequence=BAB15734.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SCAF1 Gene

Proteomics data for SCAF1 Gene at MOPED

Post-translational modifications for SCAF1 Gene

  • Ubiquitination at Lys 55, Lys 158, and Lys 1123
  • Modification sites at PhosphoSitePlus

Other Protein References for SCAF1 Gene

No data available for DME Specific Peptides for SCAF1 Gene

Domains & Families for SCAF1 Gene

Protein Domains for SCAF1 Gene


Suggested Antigen Peptide Sequences for SCAF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the splicing factor SR family.
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SCAF1: view

No data available for Gene Families for SCAF1 Gene

Function for SCAF1 Gene

Molecular function for SCAF1 Gene

UniProtKB/Swiss-Prot Function:
May function in pre-mRNA splicing.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estrogens, androgens and glucocorticoids.
genes like me logo Genes that share phenotypes with SCAF1: view

Animal Model Products

CRISPR Products

miRNA for SCAF1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAF1 Gene

Localization for SCAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAF1 Gene

Subcellular locations from

Jensen Localization Image for SCAF1 Gene COMPARTMENTS Subcellular localization image for SCAF1 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for SCAF1 Gene

Pathways & Interactions for SCAF1 Gene

SuperPathways for SCAF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAF1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SCAF1 Gene

Drugs & Compounds for SCAF1 Gene

No Compound Related Data Available

Transcripts for SCAF1 Gene

Unigene Clusters for SCAF1 Gene

SR-related CTD-associated factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCAF1 Gene

No ASD Table

Relevant External Links for SCAF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAF1 Gene

mRNA expression in normal human tissues for SCAF1 Gene

Protein differential expression in normal tissues from HIPED for SCAF1 Gene

This gene is overexpressed in Liver, secretome (12.9), Cerebrospinal fluid (11.2), and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCAF1 Gene

SOURCE GeneReport for Unigene cluster for SCAF1 Gene Hs.103521

mRNA Expression by UniProt/SwissProt for SCAF1 Gene

Tissue specificity: Ubiquitous. Highly expressed in fetal brain and liver, poorly expressed in salivary gland, heart, skin and ovary. Expressed in colorectal carcinomas and ovarian cancers. Overexpressed in colorectal carcinomas as compared to normal colonic mucosa.
genes like me logo Genes that share expression patterns with SCAF1: view

Protein tissue co-expression partners for SCAF1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SCAF1 Gene

Orthologs for SCAF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCAF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SCAF1 35
  • 89.26 (n)
  • 94.15 (a)
SCAF1 36
  • 88 (a)
(Canis familiaris)
Mammalia SCAF1 35
  • 89.8 (n)
  • 95.6 (a)
SCAF1 36
  • 87 (a)
(Pan troglodytes)
Mammalia SCAF1 35
  • 96.78 (n)
  • 95.99 (a)
SCAF1 36
  • 94 (a)
(Monodelphis domestica)
Mammalia SCAF1 36
  • 38 (a)
(Mus musculus)
Mammalia Scaf1 36
  • 78 (a)
(Anolis carolinensis)
Reptilia SCAF1 36
  • 40 (a)
(Danio rerio)
Actinopterygii Dr.19086 35
scaf1 36
  • 21 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10928 35
fruit fly
(Drosophila melanogaster)
Insecta CG2926 36
  • 8 (a)
(Zea mays)
Liliopsida Zm.10149 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 8 (a)
Species with no ortholog for SCAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCAF1 Gene

Gene Tree for SCAF1 (if available)
Gene Tree for SCAF1 (if available)

Paralogs for SCAF1 Gene

Paralogs for SCAF1 Gene

genes like me logo Genes that share paralogs with SCAF1: view

Variants for SCAF1 Gene

Sequence variations from dbSNP and Humsavar for SCAF1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3745470 - 49,653,072(-) CTTGG(C/T)GCTGC reference, missense
rs2304208 - 49,654,689(-) GGGTC(A/G)TCCCC reference, missense
rs7258381 -- 49,649,784(+) GCCAC(C/T)CCACC intron-variant
rs7259683 -- 49,650,075(+) CTCTT(C/T)GGGGG intron-variant
rs12976076 -- 49,651,151(+) CCCAC(C/T)GGCTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SCAF1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833864 CNV Gain 17160897
nsv828578 CNV Loss 20364138
nsv469715 CNV Complex 16826518
nsv833865 CNV Gain+Loss 17160897
nsv912266 CNV Loss 21882294
dgv3972n71 CNV Loss 21882294
nsv912269 CNV Loss 21882294
nsv817854 CNV Gain 17921354
nsv470150 CNV Gain 18288195
dgv3973n71 CNV Loss 21882294

Variation tolerance for SCAF1 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCAF1 Gene

Disorders for SCAF1 Gene

Relevant External Links for SCAF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SCAF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAF1 Gene

Publications for SCAF1 Gene

  1. Cloning of a gene (SR-A1), encoding for a new member of the human Ser/Arg-rich family of pre-mRNA splicing factors: overexpression in aggressive ovarian cancer. (PMID: 11461075) Scorilas A. … Diamandis E.P. (Br. J. Cancer 2001) 2 3 4 23 67
  2. Expression analysis and prognostic significance of the SRA1 gene, in ovarian cancer. (PMID: 16631123) Leoutsakou T. … Scorilas A. (Biochem. Biophys. Res. Commun. 2006) 3 23
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SCAF1 Gene

Sources for SCAF1 Gene