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Aliases for SBSN Gene

Aliases for SBSN Gene

  • Suprabasin 2 3
  • HLAR698 3
  • UNQ698 3

External Ids for SBSN Gene

Previous GeneCards Identifiers for SBSN Gene

  • GC19M040708
  • GC19M036014
  • GC19M032519

Summaries for SBSN Gene

GeneCards Summary for SBSN Gene

SBSN (Suprabasin) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBSN Gene

Genomics for SBSN Gene

Regulatory Elements for SBSN Gene

Genomic Location for SBSN Gene

Start:
35,523,367 bp from pter
End:
35,528,351 bp from pter
Size:
4,985 bases
Orientation:
Minus strand

Genomic View for SBSN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SBSN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBSN Gene

Proteins for SBSN Gene

  • Protein details for SBSN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWP8-SBSN_HUMAN
    Recommended name:
    Suprabasin
    Protein Accession:
    Q6UWP8
    Secondary Accessions:
    • A8K5J0
    • E9PBV3

    Protein attributes for SBSN Gene

    Size:
    590 amino acids
    Molecular mass:
    60541 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SBSN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SBSN Gene

Proteomics data for SBSN Gene at MOPED

Post-translational modifications for SBSN Gene

  • Glycosylation at Thr59
  • Modification sites at PhosphoSitePlus

Other Protein References for SBSN Gene

No data available for DME Specific Peptides for SBSN Gene

Domains for SBSN Gene

Protein Domains for SBSN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SBSN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SBSN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SBSN Gene

Function for SBSN Gene

Molecular function for SBSN Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated in differentiating keratinocytes.

Gene Ontology (GO) - Molecular Function for SBSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SBSN: view

Animal Model Products

miRNA for SBSN Gene

miRTarBase miRNAs that target SBSN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SBSN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SBSN Gene

Localization for SBSN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SBSN Gene

Secreted.

Gene Ontology (GO) - Cellular Components for SBSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SBSN: view

No data available for Subcellular locations from COMPARTMENTS for SBSN Gene

Pathways for SBSN Gene

SuperPathways for SBSN Gene

No Data Available

Interacting Proteins for SBSN Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000430242%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000430242 for SBSN Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for SBSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SBSN: view

No data available for Pathways by source for SBSN Gene

Transcripts for SBSN Gene

Unigene Clusters for SBSN Gene

Suprabasin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SBSN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SBSN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for SBSN Gene

GeneLoc Exon Structure for
SBSN
ECgene alternative splicing isoforms for
SBSN

Expression for SBSN Gene

mRNA expression in normal human tissues for SBSN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SBSN Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (18.9), Skin - Not Sun Exposed (Suprapubic) (16.1), Esophagus - Mucosa (7.0), Vagina (5.1), and Cervix - Ectocervix (4.0).

Protein differential expression in normal tissues for SBSN Gene

This gene is overexpressed in Cervix (56.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SBSN Gene

SOURCE GeneReport for Unigene cluster for SBSN Gene Hs.433484

mRNA Expression by UniProt/SwissProt for SBSN Gene

Q6UWP8-SBSN_HUMAN
Tissue specificity: Detected in thymus, uterus and esophagus.
genes like me logo Genes that share expressions with SBSN: view

Expression partners for SBSN Gene

In Situ Assay Products

Orthologs for SBSN Gene

This gene was present in the common ancestor of mammals.

Orthologs for SBSN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SBSN 35
  • 81.27 (n)
  • 71.35 (a)
SBSN 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SBSN 35
  • 76.87 (n)
  • 68.85 (a)
SBSN 36
  • 47 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sbsn 35
  • 72.44 (n)
  • 56.1 (a)
Sbsn 16
Sbsn 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sbsn 35
  • 75.61 (n)
  • 62.66 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SBSN 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SBSN 36
  • 74 (a)
OneToOne
Species with no ortholog for SBSN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SBSN Gene

ENSEMBL:
Gene Tree for SBSN (if available)
TreeFam:
Gene Tree for SBSN (if available)

Paralogs for SBSN Gene

No data available for Paralogs for SBSN Gene

Variants for SBSN Gene

Sequence variations from dbSNP and Humsavar for SBSN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1029387 -- 35,529,739(+) ACAGT(A/G)GGTGC upstream-variant-2KB
rs2285511 -- 35,524,963(+) CACAA(A/C)CGCGG intron-variant
rs2285512 -- 35,524,971(+) CGGAG(A/G)GTCTC intron-variant
rs2285513 -- 35,525,296(+) ACTCC(A/G)CTGAT intron-variant
rs3815018 -- 35,523,716(+) TCCCC(A/G)CAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SBSN Gene

Variant ID Type Subtype PubMed ID
nsv833811 CNV Gain 17160897
nsv911628 CNV Loss 21882294
esv27260 CNV Loss 19812545
esv2718498 CNV Deletion 23290073
esv1366374 CNV Deletion 17803354
esv1003511 CNV Deletion 20482838

Relevant External Links for SBSN Gene

HapMap Linkage Disequilibrium report
SBSN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBSN Gene

Disorders for SBSN Gene

No disorders were found for SBSN Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SBSN Gene

Publications for SBSN Gene

  1. Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor. (PMID: 12228223) Park G.T. … Morasso M.I. (J. Biol. Chem. 2002) 2 3 4 23
  2. Identification of novel keratinocyte-secreted peptides dermokine- alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1. (PMID: 15234001) Matsui T. … Tsukita S. (Genomics 2004) 3 23
  3. Identification of a conserved cluster of skin-specific genes encoding secreted proteins. (PMID: 15256262) Moffatt P. … LanctA't C. (Gene 2004) 3 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 3

Products for SBSN Gene

Sources for SBSN Gene

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